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Tytuł:
Circulating metabolic profile in idiopathic pulmonary fibrosis: data from the IPF-PRO Registry.
Autorzy:
Summer R; Thomas Jefferson University, Philadelphia, PA, USA. .
Todd JL; Duke Clinical Research Institute, Durham, NC, USA.; Duke University Medical Center, Durham, NC, USA.
Neely ML; Duke Clinical Research Institute, Durham, NC, USA.; Duke University Medical Center, Durham, NC, USA.
Lobo LJ; University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Namen A; Wake Forest School of Medicine, Winston-Salem, NC, USA.
Newby LK; Duke Clinical Research Institute, Durham, NC, USA.; Duke University Medical Center, Durham, NC, USA.
Shafazand S; University of Miami, Miami, FL, USA.
Suliman S; Banner University Medical Center, Phoenix, AZ, USA.
Hesslinger C; Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany.
Keller S; Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany.
Leonard TB; Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, CT, USA.
Palmer SM; Duke Clinical Research Institute, Durham, NC, USA.; Duke University Medical Center, Durham, NC, USA.
Ilkayeva O; Duke Molecular Physiology Institute, Durham, NC, USA.; Department of Medicine, Division of Endocrinology, Metabolism, and Nutrition, Duke University School of Medicine, Durham, NC, USA.
Muehlbauer MJ; Duke Molecular Physiology Institute, Durham, NC, USA.
Newgard CB; Duke Molecular Physiology Institute, Durham, NC, USA.
Roman J; Jane and Leonard Korman Institute, Thomas Jefferson University, Philadelphia, PA, USA.
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Źródło:
Respiratory research [Respir Res] 2024 Jan 25; Vol. 25 (1), pp. 58. Date of Electronic Publication: 2024 Jan 25.
Typ publikacji:
Clinical Study; Journal Article
MeSH Terms:
Carnitine*/analogs & derivatives
Idiopathic Pulmonary Fibrosis*/metabolism
Humans ; Ceramides ; Disease Progression ; Fatty Acids ; Metabolome ; Registries
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Ildr1 gene deletion protects against diet-induced obesity and hyperglycemia.
Autorzy:
Chandra R; Department of Medicine, Division of Gastroenterology, Duke University Medical Center, Durham, North Carolina, United States of America.
Aryal DK; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, United States of America.
Douros JD; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States of America.
Shahid R; Department of Medicine, Division of Gastroenterology, Duke University Medical Center, Durham, North Carolina, United States of America.
Davis SJ; Department of Medicine, Division of Gastroenterology, Duke University Medical Center, Durham, North Carolina, United States of America.; Swarthmore College, Swarthmore, Pennsylvania, United States of America.
Campbell JE; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States of America.
Ilkayeya O; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States of America.; Sarah W. Stedman Nutrition and Metabolism Center, Duke University, Durham, North Carolina, United States of America.
White PJ; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States of America.; Sarah W. Stedman Nutrition and Metabolism Center, Duke University, Durham, North Carolina, United States of America.
Rodriguez R; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, United States of America.; Mouse Behavioral and Neuroendocrine Analysis Core Facility, Duke University, Durham, North Carolina, United States of America.
Newgard CB; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States of America.; Sarah W. Stedman Nutrition and Metabolism Center, Duke University, Durham, North Carolina, United States of America.
Wetsel WC; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, United States of America.; Mouse Behavioral and Neuroendocrine Analysis Core Facility, Duke University, Durham, North Carolina, United States of America.; Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, United States of America.; Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, United States of America.
Liddle RA; Department of Medicine, Division of Gastroenterology, Duke University Medical Center, Durham, North Carolina, United States of America.; Department of Veterans Affairs Medical Center, Durham, North Carolina, United States of America.
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Źródło:
PloS one [PLoS One] 2022 Jun 24; Vol. 17 (6), pp. e0270329. Date of Electronic Publication: 2022 Jun 24 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Hyperglycemia*/genetics
Insulin Resistance*/genetics
Receptors, Cell Surface/*metabolism
Animals ; Cholecystokinin ; Diet, High-Fat ; Gene Deletion ; Glucose/metabolism ; Insulin/metabolism ; Mice ; Mice, Inbred C57BL ; Obesity/genetics ; Obesity/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Association of lipid profile biomarkers with breast cancer by molecular subtype: analysis of the MEND study.
Autorzy:
Gupta A; Trinity College of Arts and Sciences, Duke University, Durham, NC, USA.; Department of Population Health Sciences, School of Medicine, Duke University, 215 Morris Street, Durham, NC, 27708, USA.
Saraiya V; Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA.
Deveaux A; Department of Population Health Sciences, School of Medicine, Duke University, 215 Morris Street, Durham, NC, 27708, USA.
Oyekunle T; Department of Population Health Sciences, School of Medicine, Duke University, 215 Morris Street, Durham, NC, 27708, USA.
Jackson KD; Divison of Pharmacotherapy and Experimental Therapeutics, University of North Carolina at Chapel Hill Eshelman School of Pharmacy, Chapel Hill, NC, USA.
Salako O; College of Medicine &, Lagos University Teaching Hospital, University of Lagos, Lagos, Lagos State, Nigeria.
Daramola A; College of Medicine &, Lagos University Teaching Hospital, University of Lagos, Lagos, Lagos State, Nigeria.
Hall A; Department of Pathology, School of Medicine, Duke University, Durham, NC, USA.
Alatise O; Obafemi Awolowo University Teaching Hospital, Ile-Ife, Osun State, Nigeria.
Ogun G; Unversity College Hospital, University of Ibadan, Ibadan, Oyo State, Nigeria.
Adeniyi A; Federal Medical Center, Ogun State, Abeokuta, Nigeria.
Ayandipo O; Unversity College Hospital, University of Ibadan, Ibadan, Oyo State, Nigeria.
Olajide T; College of Medicine &, Lagos University Teaching Hospital, University of Lagos, Lagos, Lagos State, Nigeria.
Olasehinde O; Obafemi Awolowo University Teaching Hospital, Ile-Ife, Osun State, Nigeria.
Arowolo O; Obafemi Awolowo University Teaching Hospital, Ile-Ife, Osun State, Nigeria.
Adisa A; Obafemi Awolowo University Teaching Hospital, Ile-Ife, Osun State, Nigeria.
Afuwape O; Unversity College Hospital, University of Ibadan, Ibadan, Oyo State, Nigeria.
Olusanya A; Unversity College Hospital, University of Ibadan, Ibadan, Oyo State, Nigeria.
Adegoke A; Our Lady of Apostle Catholic Hospital, Ibadan, Oyo State, Nigeria.
Tollefsbol TO; University of Alabama at Birmingham, Birmingham, AL, USA.
Arnett D; College of Public Health, University of Kentucky, Lexington, KY, USA.
Muehlbauer MJ; Duke Molecular Physiology Institute, Duke University, Durham, NC, USA.
Newgard CB; Duke Molecular Physiology Institute, Duke University, Durham, NC, USA.
Akinyemiju T; Department of Population Health Sciences, School of Medicine, Duke University, 215 Morris Street, Durham, NC, 27708, USA. .; Duke Cancer Institute, School of Medicine, Duke University, Durham, NC, USA. .; Duke Global Health Institute, Duke University, Durham, NC, USA. .
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Corporate Authors:
H3 Africa Kidney Research Network
Źródło:
Scientific reports [Sci Rep] 2022 Jun 23; Vol. 12 (1), pp. 10631. Date of Electronic Publication: 2022 Jun 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Breast Neoplasms*
Triple Negative Breast Neoplasms*/epidemiology
Biomarkers ; Cholesterol, HDL ; Cholesterol, LDL ; Female ; Humans ; Prospective Studies ; Risk Factors ; Triglycerides
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Circulating long chain acylcarnitines and outcomes in diabetic heart failure: an HF-ACTION clinical trial substudy.
Autorzy:
Truby LK; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, 27710, USA.; Department of Medicine, Division of Cardiology, Duke University School of Medicine, Durham, NC, USA.
Regan JA; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, 27710, USA.; Department of Medicine, Division of Cardiology, Duke University School of Medicine, Durham, NC, USA.
Giamberardino SN; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, 27710, USA.
Ilkayeva O; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, 27710, USA.
Bain J; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, 27710, USA.
Newgard CB; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, 27710, USA.
O'Connor CM; Inova Heart and Vascular Institute, Falls Church, NC, USA.
Felker GM; Department of Medicine, Division of Cardiology, Duke University School of Medicine, Durham, NC, USA.
Kraus WE; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, 27710, USA.; Department of Medicine, Division of Cardiology, Duke University School of Medicine, Durham, NC, USA.
McGarrah RW; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, 27710, USA.; Department of Medicine, Division of Cardiology, Duke University School of Medicine, Durham, NC, USA.
Shah SH; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, 27710, USA. .; Department of Medicine, Division of Cardiology, Duke University School of Medicine, Durham, NC, USA. .; Precision Genomics Collaboratory, Duke University School of Medicine, Durham, USA. .
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Źródło:
Cardiovascular diabetology [Cardiovasc Diabetol] 2021 Aug 03; Vol. 20 (1), pp. 161. Date of Electronic Publication: 2021 Aug 03.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Exercise Tolerance*
Carnitine/*analogs & derivatives
Diabetic Cardiomyopathies/*blood
Heart Failure/*blood
Aged ; Biomarkers/blood ; Carnitine/blood ; Clinical Trials as Topic ; Diabetic Cardiomyopathies/diagnosis ; Diabetic Cardiomyopathies/mortality ; Diabetic Cardiomyopathies/physiopathology ; Female ; Health Status ; Heart Failure/diagnosis ; Heart Failure/mortality ; Heart Failure/physiopathology ; Hospitalization ; Humans ; Male ; Metabolome ; Metabolomics ; Middle Aged ; Prognosis ; Risk Assessment ; Risk Factors ; Tandem Mass Spectrometry ; Time Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Metabolomic profiling identifies complex lipid species and amino acid analogues associated with response to weight loss interventions.
Autorzy:
Bihlmeyer NA; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States of America.
Kwee LC; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States of America.
Clish CB; Metabolomics Platform, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America.
Deik AA; Metabolomics Platform, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America.
Gerszten RE; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America.
Pagidipati NJ; Duke Clinical Research Institute, Duke University, Durham, North Carolina, United States of America.; Department of Medicine, Duke University School of Medicine, Durham, North Carolina, United States of America.
Laferrère B; Columbia University Irving Medical Center, New York, New York, United States of America.
Svetkey LP; Department of Medicine, Duke University School of Medicine, Durham, North Carolina, United States of America.
Newgard CB; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States of America.
Kraus WE; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States of America.
Shah SH; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States of America.; Duke Clinical Research Institute, Duke University, Durham, North Carolina, United States of America.; Department of Medicine, Duke University School of Medicine, Durham, North Carolina, United States of America.
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Źródło:
PloS one [PLoS One] 2021 May 27; Vol. 16 (5), pp. e0240764. Date of Electronic Publication: 2021 May 27 (Print Publication: 2021).
Typ publikacji:
Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Metabolomics*
Biomarkers/*blood
Obesity/*blood
Weight Loss/*physiology
Adult ; Body Mass Index ; Diglycerides/blood ; Female ; Humans ; Insulin Resistance/physiology ; Lipid Metabolism/physiology ; Lipids/blood ; Male ; Mass Spectrometry ; Middle Aged ; Obesity/metabolism ; Obesity/surgery ; Obesity/therapy ; Triglycerides/blood
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Efficacy of metformin and fermentable fiber combination therapy in adolescents with severe obesity and insulin resistance: study protocol for a double-blind randomized controlled trial.
Autorzy:
Deehan EC; Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, T6G 2E1, AB, Canada.
Colin-Ramirez E; Department of Pediatrics, University of Alberta, Edmonton, T6G 2E1, AB, Canada.
Triador L; Department of Pediatrics, University of Alberta, Edmonton, T6G 2E1, AB, Canada.
Madsen KL; Department of Medicine, University of Alberta, Edmonton, T6G 2C2, AB, Canada.
Prado CM; Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, T6G 2E1, AB, Canada.
Field CJ; Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, T6G 2E1, AB, Canada.
Ball GDC; Department of Pediatrics, University of Alberta, Edmonton, T6G 2E1, AB, Canada.
Tan Q; Department of Pediatrics, University of Alberta, Edmonton, T6G 2E1, AB, Canada.
Orsso C; Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, T6G 2E1, AB, Canada.
Dinu I; School of Public Health, University of Alberta, Edmonton, T6G 1C9, AB, Canada.
Pakseresht M; Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, T6G 2E1, AB, Canada.
Rubin D; California State University Fullerton, Fullerton, USA.
Sharma AM; Department of Medicine, University of Alberta, Edmonton, T6G 2C2, AB, Canada.
Tun H; University of Hong Kong School of Public Health, Hong Kong, China.
Walter J; DNational University of Ireland University College Cork, University College Cork, Cork, Ireland.
Newgard CB; Duke University Medical Center, Duke University Hospital, Durham, NC, USA.
Freemark M; Duke University Medical Center, Duke University Hospital, Durham, NC, USA.
Wine E; Department of Pediatrics and Physiology, University of Alberta, Edmonton, T6G 1C9, BA, Canada.
Haqq AM; Department of Pediatrics, University of Alberta, Edmonton, T6G 2E1, AB, Canada. .
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Źródło:
Trials [Trials] 2021 Feb 17; Vol. 22 (1), pp. 148. Date of Electronic Publication: 2021 Feb 17.
Typ publikacji:
Clinical Trial Protocol; Journal Article
MeSH Terms:
Diabetes Mellitus, Type 2*
Insulin Resistance*
Metformin*/adverse effects
Obesity, Morbid*
Adolescent ; Double-Blind Method ; Humans ; Hypoglycemic Agents/adverse effects ; Randomized Controlled Trials as Topic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Identification of a small molecule that stimulates human β-cell proliferation and insulin secretion, and protects against cytotoxic stress in rat insulinoma cells.
Autorzy:
Hohmeier HE; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States of America.; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina, United States of America.; Division of Endocrinology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America.
Zhang L; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States of America.; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina, United States of America.
Taylor B; Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America.
Stephens S; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States of America.; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina, United States of America.
Lu D; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States of America.; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina, United States of America.
McNamara P; Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America.
Laffitte B; Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America.
Newgard CB; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States of America.; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina, United States of America.; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, United States of America.; Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America.
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Źródło:
PloS one [PLoS One] 2020 Mar 16; Vol. 15 (3), pp. e0224344. Date of Electronic Publication: 2020 Mar 16 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Proliferation/*drug effects
Insulin Secretion/*drug effects
Insulin-Secreting Cells/*metabolism
Insulinoma/*metabolism
Protein Kinase Inhibitors/*pharmacology
Animals ; Cell Line, Tumor ; Glucagon-Secreting Cells/metabolism ; Glucagon-Secreting Cells/pathology ; Glucose/pharmacology ; Homeodomain Proteins/metabolism ; Humans ; Insulin-Secreting Cells/pathology ; Insulinoma/pathology ; Neoplasm Proteins/antagonists & inhibitors ; Neoplasm Proteins/metabolism ; Protein Serine-Threonine Kinases/antagonists & inhibitors ; Protein Serine-Threonine Kinases/metabolism ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Protein-Tyrosine Kinases/metabolism ; Rats ; Dyrk Kinases
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Effects of microbiota-directed foods in gnotobiotic animals and undernourished children.
Autorzy:
Gehrig JL; Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63110, USA.
Venkatesh S; Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63110, USA.
Chang HW; Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63110, USA.
Hibberd MC; Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63110, USA.
Kung VL; Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Cheng J; Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63110, USA.
Chen RY; Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63110, USA.
Subramanian S; Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63110, USA.
Cowardin CA; Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63110, USA.
Meier MF; Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63110, USA.
O'Donnell D; Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63110, USA.
Talcott M; Division of Comparative Medicine, Washington University, St. Louis, MO 63110, USA.
Spears LD; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Semenkovich CF; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Henrissat B; Architecture et Fonction des Macromolécules Biologiques, Centre National de la Recherche Scientifique and Aix-Marseille Université, 13288 Marseille cedex 9, France.; Department of Biological Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
Giannone RJ; Chemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37830, USA.
Hettich RL; Chemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37830, USA.
Ilkayeva O; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27710, USA.; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC 27710, USA.
Muehlbauer M; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27710, USA.; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC 27710, USA.
Newgard CB; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27710, USA.; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC 27710, USA.; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Sawyer C; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.; Genome Technology Access Center, Washington University School of Medicine, St. Louis, MO 63110, USA.
Head RD; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.; Genome Technology Access Center, Washington University School of Medicine, St. Louis, MO 63110, USA.
Rodionov DA; A. A. Kharkevich Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow 127994, Russia.; Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Arzamasov AA; A. A. Kharkevich Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow 127994, Russia.; Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Leyn SA; A. A. Kharkevich Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow 127994, Russia.; Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Osterman AL; Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Hossain MI; International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, Bangladesh.
Islam M; International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, Bangladesh.
Choudhury N; International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, Bangladesh.
Sarker SA; International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, Bangladesh.
Huq S; International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, Bangladesh.
Mahmud I; International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, Bangladesh.
Mostafa I; International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, Bangladesh.
Mahfuz M; International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, Bangladesh.
Barratt MJ; Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63110, USA.
Ahmed T; International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, Bangladesh.
Gordon JI; Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA. .; Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63110, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2019 Jul 12; Vol. 365 (6449).
Typ publikacji:
Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Gastrointestinal Microbiome*
Germ-Free Life*
Host Microbial Interactions*
Infant Nutritional Physiological Phenomena*
Child Nutrition Disorders/*diet therapy
Child Nutrition Disorders/*microbiology
Animals ; Bangladesh ; Blood Proteins/analysis ; Child Nutrition Disorders/metabolism ; Child, Preschool ; Humans ; Infant
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Disrupted Maturation of the Microbiota and Metabolome among Extremely Preterm Infants with Postnatal Growth Failure.
Autorzy:
Younge NE; Division of Neonatology, Department of Pediatrics, Duke University, Durham, NC, 27710, USA. .
Newgard CB; Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University, Durham, NC, 27701, USA.; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, 27710, USA.; Division of Endocrinology and Metabolism, Department of Medicine, Duke University, Durham, NC, 27710, USA.
Cotten CM; Division of Neonatology, Department of Pediatrics, Duke University, Durham, NC, 27710, USA.
Goldberg RN; Division of Neonatology, Department of Pediatrics, Duke University, Durham, NC, 27710, USA.
Muehlbauer MJ; Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University, Durham, NC, 27701, USA.
Bain JR; Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University, Durham, NC, 27701, USA.; Division of Endocrinology and Metabolism, Department of Medicine, Duke University, Durham, NC, 27710, USA.
Stevens RD; Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University, Durham, NC, 27701, USA.; Division of Endocrinology and Metabolism, Department of Medicine, Duke University, Durham, NC, 27710, USA.
O'Connell TM; Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University, Durham, NC, 27701, USA.; Department of Otolaryngology, Head and Neck Surgery, Indiana University, Indianapolis, IN, 46202, USA.
Rawls JF; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, 27710, USA.
Seed PC; Department of Pediatrics, Northwestern University, Chicago, IL, 60611, USA.
Ashley PL; Division of Neonatology, Department of Pediatrics, Duke University, Durham, NC, 27710, USA.
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Źródło:
Scientific reports [Sci Rep] 2019 Jun 03; Vol. 9 (1), pp. 8167. Date of Electronic Publication: 2019 Jun 03.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Metabolomics*
Bacteria/*genetics
Gastrointestinal Microbiome/*genetics
Infant, Extremely Premature/*growth & development
Adult ; Bacteria/classification ; Bacteria/isolation & purification ; Enterobacteriaceae/genetics ; Enterobacteriaceae/isolation & purification ; Feces/microbiology ; Female ; Gestational Age ; Humans ; Infant ; Infant, Extremely Premature/metabolism ; Infant, Newborn ; Male ; Metabolome/genetics ; Pregnancy ; RNA, Ribosomal, 16S/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Branched-chain amino acids in disease.
Autorzy:
White PJ; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA, and Department of Pharmacology and Cancer Biology, and Department of Medicine, Endocrine Division, Duke University Medical Center, Durham, NC 27701, USA.
Newgard CB; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA, and Department of Pharmacology and Cancer Biology, and Department of Medicine, Endocrine Division, Duke University Medical Center, Durham, NC 27701, USA. chris.newgard@duke.edu.
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Źródło:
Science (New York, N.Y.) [Science] 2019 Feb 08; Vol. 363 (6427), pp. 582-583.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Amino Acids, Branched-Chain/*blood
Amino Acids, Branched-Chain/*metabolism
Diabetes Mellitus, Type 2/*physiopathology
Obesity/*physiopathology
Animals ; Diet ; Dietary Carbohydrates ; Disease Models, Animal ; Dyslipidemias/physiopathology ; Humans ; Insulin Resistance
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructose.
Autorzy:
Meyer JG; Buck Institute for Research on Aging, Novato, California, United States of America.
Softic S; Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.; Boston Children's Hospital, Division of Gastroenterology, Boston, Massachusetts, United States of America.
Basisty N; Buck Institute for Research on Aging, Novato, California, United States of America.
Rardin MJ; Discovery Attribute Sciences, Therapeutic Discovery, Amgen, South San Francisco, California, United States of America.
Verdin E; Buck Institute for Research on Aging, Novato, California, United States of America.
Gibson BW; Discovery Attribute Sciences, Therapeutic Discovery, Amgen, South San Francisco, California, United States of America.
Ilkayeva O; Sarah W. Stedman Nutrition and Metabolism Center and Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina, United States of America.
Newgard CB; Sarah W. Stedman Nutrition and Metabolism Center and Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina, United States of America.; Department of Pharmacology and Cancer Biology and Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America.; Department of Medicine, Division of Endocrinology, Metabolism, and Nutrition, Duke University Medical Center, Durham, North Carolina, United States of America.
Kahn CR; Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.
Schilling B; Buck Institute for Research on Aging, Novato, California, United States of America.
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Źródło:
PloS one [PLoS One] 2018 Dec 26; Vol. 13 (12), pp. e0208973. Date of Electronic Publication: 2018 Dec 26 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Fatty Liver/*metabolism
Liver/*metabolism
Mitochondria, Liver/*drug effects
Mitochondrial Proteins/*genetics
Acetylation/drug effects ; Animals ; Citric Acid/metabolism ; Diet, High-Fat/adverse effects ; Fatty Liver/genetics ; Fatty Liver/pathology ; Glucose/metabolism ; Humans ; Lipid Metabolism/drug effects ; Liver/drug effects ; Mice ; Mitochondria/drug effects ; Mitochondria/genetics ; Mitochondrial Proteins/drug effects ; Protein Processing, Post-Translational/drug effects ; Protein Processing, Post-Translational/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Kruppel-like factor 15 is required for the cardiac adaptive response to fasting.
Autorzy:
Sugi K; Case Cardiovascular Research Institute and Harrington Heart & Vascular Institute, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America.; Department of Medicine, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America.
Hsieh PN; Case Cardiovascular Research Institute and Harrington Heart & Vascular Institute, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America.; Department of Medicine, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America.; Department of Pathology, Case Western Reserve University, Cleveland, OH, United States of America.
Ilkayeva O; Sarah W. Stedman Nutrition and Metabolism Center, Departments of Medicine and Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, United States of America.
Shelkay S; Case Cardiovascular Research Institute and Harrington Heart & Vascular Institute, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America.; Department of Medicine, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America.
Moroney B; Case Cardiovascular Research Institute and Harrington Heart & Vascular Institute, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America.; Department of Medicine, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America.
Baadh P; Case Cardiovascular Research Institute and Harrington Heart & Vascular Institute, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America.; Department of Medicine, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America.
Haynes B; Case Cardiovascular Research Institute and Harrington Heart & Vascular Institute, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America.; Department of Medicine, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America.
Pophal M; Case Cardiovascular Research Institute and Harrington Heart & Vascular Institute, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America.; Department of Medicine, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America.
Fan L; Case Cardiovascular Research Institute and Harrington Heart & Vascular Institute, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America.; Department of Medicine, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America.; Department of Pathology, Case Western Reserve University, Cleveland, OH, United States of America.
Newgard CB; Sarah W. Stedman Nutrition and Metabolism Center, Departments of Medicine and Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, United States of America.
Prosdocimo DA; Case Cardiovascular Research Institute and Harrington Heart & Vascular Institute, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America.; Department of Medicine, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America.
Jain MK; Case Cardiovascular Research Institute and Harrington Heart & Vascular Institute, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America.; Department of Medicine, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America.
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Źródło:
PloS one [PLoS One] 2018 Feb 06; Vol. 13 (2), pp. e0192376. Date of Electronic Publication: 2018 Feb 06 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Adaptation, Physiological*
DNA-Binding Proteins/*physiology
Fasting/*physiology
Heart/*physiology
Transcription Factors/*physiology
Animals ; Carnitine/analogs & derivatives ; Carnitine/metabolism ; DNA-Binding Proteins/genetics ; Echocardiography ; Kruppel-Like Transcription Factors ; Lipid Metabolism ; Male ; Mice ; Mice, Knockout ; Mitochondria, Heart/metabolism ; Transcription Factors/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Effects of the kinase inhibitor sorafenib on heart, muscle, liver and plasma metabolism in vivo using non-targeted metabolomics analysis.
Autorzy:
Jensen BC; McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA.; Department of Internal Medicine, Division of Cardiology University of North Carolina, Chapel Hill, NC, USA.; Department of Pharmacology, University of North Carolina, Chapel Hill, NC, USA.
Parry TL; McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA.; Department of Pathology & Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA.
Huang W; McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA.
Beak JY; McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA.
Ilaiwy A; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.; Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Bain JR; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.; Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Newgard CB; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.; Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Muehlbauer MJ; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.
Patterson C; Presbyterian Hospital/Weill-Cornell Medical Center, New York, NY, USA.
Johnson GL; Department of Pharmacology, University of North Carolina, Chapel Hill, NC, USA.
Willis MS; McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA.; Department of Pathology & Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA.; Department of Pharmacology, University of North Carolina, Chapel Hill, NC, USA.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2017 Dec; Vol. 174 (24), pp. 4797-4811. Date of Electronic Publication: 2017 Nov 24.
Typ publikacji:
Journal Article
MeSH Terms:
Metabolomics*
Heart/*drug effects
Liver/*drug effects
Muscle, Skeletal/*drug effects
Niacinamide/*analogs & derivatives
Phenylurea Compounds/*pharmacology
Plasma/*drug effects
Protein Kinase Inhibitors/*pharmacology
Animals ; Liver/metabolism ; Mice ; Mice, Inbred Strains ; Muscle, Skeletal/metabolism ; Niacinamide/chemistry ; Niacinamide/pharmacology ; Phenylurea Compounds/chemistry ; Plasma/metabolism ; Protein Kinase Inhibitors/chemistry ; Sorafenib ; Tissue Distribution
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Delayed apoptosis allows islet β-cells to implement an autophagic mechanism to promote cell survival.
Autorzy:
Hayes HL; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States of America.
Peterson BS; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States of America.; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina, United States of America.; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, United States of America.
Haldeman JM; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States of America.; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina, United States of America.; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, United States of America.
Newgard CB; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States of America.; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina, United States of America.; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, United States of America.; Department of Medicine, Division of Endocrinology, Duke University Medical Center, Durham, North Carolina, United States of America.
Hohmeier HE; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States of America.; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina, United States of America.; Department of Medicine, Division of Endocrinology, Duke University Medical Center, Durham, North Carolina, United States of America.
Stephens SB; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States of America.; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina, United States of America.; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, United States of America.
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Źródło:
PloS one [PLoS One] 2017 Feb 17; Vol. 12 (2), pp. e0172567. Date of Electronic Publication: 2017 Feb 17 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*physiology
Autophagy/*physiology
Islets of Langerhans/*cytology
Animals ; Apoptotic Protease-Activating Factor 1 ; Caspase 3/metabolism ; Cell Line ; Cell Survival/physiology ; Cells, Cultured ; Endoplasmic Reticulum Stress ; Glucose/metabolism ; Inhibitor of Apoptosis Proteins/metabolism ; Insulin/metabolism ; Insulin Secretion ; Insulinoma/pathology ; Islets of Langerhans/physiology ; Pancreatic Neoplasms/pathology ; Rats
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Mixture model normalization for non-targeted gas chromatography/mass spectrometry metabolomics data.
Autorzy:
Reisetter AC; Department of Preventive Medicine, Division of Biostatistics, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Muehlbauer MJ; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC, 27701, USA.; Duke University School of Medicine, Durham, NC, 27701, USA.
Bain JR; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC, 27701, USA.; Duke University School of Medicine, Durham, NC, 27701, USA.
Nodzenski M; Department of Preventive Medicine, Division of Biostatistics, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Stevens RD; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC, 27701, USA.; Duke University School of Medicine, Durham, NC, 27701, USA.
Ilkayeva O; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC, 27701, USA.; Duke University School of Medicine, Durham, NC, 27701, USA.
Metzger BE; Department of Medicine, Division of Endocrinology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Newgard CB; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC, 27701, USA.; Duke University School of Medicine, Durham, NC, 27701, USA.
Lowe WL Jr; Department of Medicine, Division of Endocrinology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Scholtens DM; Department of Preventive Medicine, Division of Biostatistics, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA. .
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Źródło:
BMC bioinformatics [BMC Bioinformatics] 2017 Feb 02; Vol. 18 (1), pp. 84. Date of Electronic Publication: 2017 Feb 02.
Typ publikacji:
Journal Article
MeSH Terms:
Gas Chromatography-Mass Spectrometry/*methods
Metabolomics/*methods
Female ; Gas Chromatography-Mass Spectrometry/standards ; Humans ; Infant, Newborn ; Metabolomics/standards ; Models, Biological ; Pregnancy ; Quality Control
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Plasma amino acid levels are elevated in young, healthy low birth weight men exposed to short-term high-fat overfeeding.
Autorzy:
Ribel-Madsen A; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark .; Department of Endocrinology, Diabetes and Metabolism, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Hellgren LI; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.
Brøns C; Department of Endocrinology, Diabetes and Metabolism, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Ribel-Madsen R; Department of Endocrinology, Diabetes and Metabolism, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.; Danish Diabetes Academy, Odense, Denmark.
Newgard CB; Sarah W. Stedman Nutrition and Metabolism Center and Duke Molecular Physiology Institute Duke University, Durham, NC, USA.
Vaag AA; Department of Endocrinology, Diabetes and Metabolism, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
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Źródło:
Physiological reports [Physiol Rep] 2016 Dec; Vol. 4 (23).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Amino Acids/*blood
Diet, High-Fat/*adverse effects
Infant, Low Birth Weight/*growth & development
Adult ; Case-Control Studies ; Dietary Fats/administration & dosage ; Dietary Fats/metabolism ; Humans ; Insulin Resistance ; Male ; Random Allocation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Plasma acylcarnitine profiling indicates increased fatty acid oxidation relative to tricarboxylic acid cycle capacity in young, healthy low birth weight men.
Autorzy:
Ribel-Madsen A; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark Department of Endocrinology, Diabetes and Metabolism, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Ribel-Madsen R; Department of Endocrinology, Diabetes and Metabolism, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark Danish Diabetes Academy, Odense, Denmark.
Brøns C; Department of Endocrinology, Diabetes and Metabolism, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Newgard CB; Sarah W. Stedman Nutrition and Metabolism, Center and Duke Molecular Physiology Institute, Duke University, Durham, NC, USA.
Vaag AA; Department of Endocrinology, Diabetes and Metabolism, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Hellgren LI; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark .
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Źródło:
Physiological reports [Physiol Rep] 2016 Oct; Vol. 4 (19).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Oxidation-Reduction*
Birth Weight/*physiology
Carnitine/*analogs & derivatives
Citric Acid Cycle/*physiology
Diabetes Mellitus, Type 2/*complications
Diet, High-Fat/*adverse effects
Dietary Fats/*administration & dosage
Fasting/*blood
Fatty Acids/*metabolism
Infant, Low Birth Weight/*physiology
Adult ; Carnitine/blood ; Carnitine/metabolism ; Cross-Over Studies ; Denmark/epidemiology ; Diabetes Mellitus, Type 2/metabolism ; Diet, High-Fat/methods ; Dietary Fats/adverse effects ; Energy Intake/physiology ; Humans ; Infant, Low Birth Weight/metabolism ; Insulin/blood ; Insulin Resistance/physiology ; Lipid Metabolism/physiology ; Male ; Mitochondria/metabolism ; Randomized Controlled Trials as Topic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children.
Autorzy:
Blanton LV; Center for Genome Sciences and Systems Biology and Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63108, USA.
Charbonneau MR; Center for Genome Sciences and Systems Biology and Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63108, USA.
Salih T; Center for Genome Sciences and Systems Biology and Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63108, USA.
Barratt MJ; Center for Genome Sciences and Systems Biology and Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63108, USA.
Venkatesh S; Center for Genome Sciences and Systems Biology and Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63108, USA.
Ilkaveya O; Sarah W. Stedman Nutrition and Metabolism Centerand Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC 27710, USA.
Subramanian S; Center for Genome Sciences and Systems Biology and Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63108, USA.
Manary MJ; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA. School of Public Health and Family Medicine, College of Medicine, University of Malawi, Chichiri, Blantyre 3, Malawi.
Trehan I; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA. Department of Paediatrics and Child Health, College of Medicine, University of Malawi, Chichiri, Blantyre 3, Malawi.
Jorgensen JM; Department of Nutrition and Program in International and Community Nutrition, University of California-Davis, Davis, CA 95616, USA.
Fan YM; Department for International Health, University of Tampere School of Medicine, Tampere 33014, Finland.
Henrissat B; Architecture et Fonction des Macromolécules Biologiques, Centre National de la Recherche Scientifique and Aix-Marseille Université, 13288 Marseille Cedex 9, France. Department of Biological Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
Leyn SA; A. A. Kharkevich Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow 127994, Russia.
Rodionov DA; A. A. Kharkevich Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow 127994, Russia. Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Osterman AL; Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Maleta KM; School of Public Health and Family Medicine, College of Medicine, University of Malawi, Chichiri, Blantyre 3, Malawi.
Newgard CB; Sarah W. Stedman Nutrition and Metabolism Centerand Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC 27710, USA. Department of Pharmacology and Cancer Biology and Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Ashorn P; Department for International Health, University of Tampere School of Medicine, Tampere 33014, Finland. Department of Pediatrics, Tampere University Hospital, Tampere 33521, Finland.
Dewey KG; Department of Nutrition and Program in International and Community Nutrition, University of California-Davis, Davis, CA 95616, USA.
Gordon JI; Center for Genome Sciences and Systems Biology and Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63108, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2016 Feb 19; Vol. 351 (6275).
Typ publikacji:
Journal Article
MeSH Terms:
Bacteria/*classification
Gastrointestinal Microbiome/*physiology
Infant Nutrition Disorders/*microbiology
Animals ; Bifidobacterium/physiology ; Body Weight ; Bone Development ; Clostridiales/physiology ; Disease Models, Animal ; Feces/microbiology ; Femur/growth & development ; Germ-Free Life ; Humans ; Infant ; Infant Nutrition Disorders/metabolism ; Malawi ; Male ; Mice ; Mice, Inbred C57BL
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis.
Autorzy:
Kraus WE; Division of Cardiology, Department of Medicine, Duke University, Durham, North Carolina, United States of America.; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States of America.
Muoio DM; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States of America.; Division of Endocrinology, Department of Medicine, Duke University, Durham, North Carolina, United States of America.
Stevens R; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States of America.
Craig D; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States of America.
Bain JR; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States of America.
Grass E; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States of America.
Haynes C; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States of America.
Kwee L; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States of America.
Qin X; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States of America.
Slentz DH; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States of America.
Krupp D; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States of America.
Muehlbauer M; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States of America.
Hauser ER; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States of America.; Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, United States of America.
Gregory SG; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States of America.
Newgard CB; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States of America.
Shah SH; Division of Cardiology, Department of Medicine, Duke University, Durham, North Carolina, United States of America.; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States of America.
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Źródło:
PLoS genetics [PLoS Genet] 2015 Nov 05; Vol. 11 (11), pp. e1005553. Date of Electronic Publication: 2015 Nov 05 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Metabolomics*
Quantitative Trait Loci*
Cardiovascular Diseases/*genetics
Proteasome Endopeptidase Complex/*genetics
Ubiquitin/*genetics
Cardiovascular Diseases/pathology ; Carnitine/analogs & derivatives ; Carnitine/metabolism ; DNA Methylation ; Endoplasmic Reticulum Stress/genetics ; Humans ; Polymorphism, Single Nucleotide ; Risk Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Non-targeted metabolomics of Brg1/Brm double-mutant cardiomyocytes reveals a novel role for SWI/SNF complexes in metabolic homeostasis.
Autorzy:
Banerjee R; University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Bultman SJ; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Holley D; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Hillhouse C; Department of Pathology & Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA.
Bain JR; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA. Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Newgard CB; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA. Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Muehlbauer MJ; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.
Willis MS; Department of Pathology & Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA. McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA.
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Źródło:
Metabolomics : Official journal of the Metabolomic Society [Metabolomics] 2015 Oct 01; Vol. 11 (5), pp. 1287-1301.
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
MuRF2 regulates PPARγ1 activity to protect against diabetic cardiomyopathy and enhance weight gain induced by a high fat diet.
Autorzy:
He J; Department of Pathology and Laboratory Medicine, University of North Carolina, 111 Mason Farm Road, MBRB 2340B, Chapel Hill, NC, USA. .; General Hospital of Ningxia Medical University, Yinchuan, Ningxia, People's Republic of China. .
Quintana MT; Department of Surgery, University of North Carolina, Chapel Hill, NC, USA. .
Sullivan J; Department of Biology, University of North Carolina, Chapel Hill, NC, USA. .
L Parry T; McAllister Heart Institute, University of North Carolina, 111 Mason Farm Road, MBRB 2340B, Chapel Hill, NC, USA. .
J Grevengoed T; Department of Nutrition, University of North Carolina, Chapel Hill, NC, USA. .
Schisler JC; McAllister Heart Institute, University of North Carolina, 111 Mason Farm Road, MBRB 2340B, Chapel Hill, NC, USA. .; Department of Pharmacology, University of North Carolina, Chapel Hill, NC, USA. .
Hill JA; Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center, Dallas, TX, USA. .
Yates CC; Department of Health Promotions and Development, School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA. .
Mapanga RF; Cardio-Metabolic Research Group (CMRG), Department of Physiological Sciences, Stellenbosch University, Stellenbosch, 7600, South Africa. .
Essop MF; Cardio-Metabolic Research Group (CMRG), Department of Physiological Sciences, Stellenbosch University, Stellenbosch, 7600, South Africa. .
Stansfield WE; Department of Surgery, University of North Carolina, Chapel Hill, NC, USA. .
Bain JR; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA. .; Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Duke University Medical Center, Durham, NC, USA. .
Newgard CB; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA. chris.newgard@duke.edu.; Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Duke University Medical Center, Durham, NC, USA. chris.newgard@duke.edu.
Muehlbauer MJ; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA. .
Han Y; East Chapel Hill High School, Chapel Hill, NC, USA. .
Clarke BA; Novartis, Novartis Institutes for BioMedical Research, Inc., 400 Technology Square, Boston, MA, 601-4214, USA. .
Willis MS; Department of Pathology and Laboratory Medicine, University of North Carolina, 111 Mason Farm Road, MBRB 2340B, Chapel Hill, NC, USA. monte_.; McAllister Heart Institute, University of North Carolina, 111 Mason Farm Road, MBRB 2340B, Chapel Hill, NC, USA. monte_.
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Źródło:
Cardiovascular diabetology [Cardiovasc Diabetol] 2015 Aug 05; Vol. 14, pp. 97. Date of Electronic Publication: 2015 Aug 05.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Diet, High-Fat*
Weight Gain*
Cardiomyopathies/*prevention & control
Muscle Proteins/*metabolism
Myocardium/*enzymology
Obesity/*etiology
PPAR gamma/*metabolism
Animals ; Cardiomyopathies/enzymology ; Cardiomyopathies/etiology ; Cardiomyopathies/genetics ; Disease Models, Animal ; Female ; Gene Expression Regulation ; Genotype ; Insulin Resistance ; Male ; Mice, Knockout ; Muscle Proteins/deficiency ; Muscle Proteins/genetics ; Obesity/enzymology ; Obesity/genetics ; PPAR gamma/genetics ; Phenotype ; RNA, Messenger/metabolism ; Signal Transduction ; Time Factors ; Ubiquitination
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Muscle ring finger-3 protects against diabetic cardiomyopathy induced by a high fat diet.
Autorzy:
Quintana MT; Department of Surgery, University of North Carolina, Chapel Hill, NC, USA. .
He J; Department of Pathology & Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA. .; General Hospital of Ningxia Medical University, Yinchuan, Ningxia, People's Republic of China. .
Sullivan J; Department of Biology, University of North Carolina, Chapel Hill, NC, USA. .
Grevengoed T; Department of Nutrition, University of North Carolina, Chapel Hill, NC, USA. .
Schisler J; McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA. .; Department of Pharmacology, University of North Carolina, Chapel Hill, NC, USA. .
Han Y; North Carolina State University, Department of Engineering, Raleigh, NC, USA. .
Hill JA; Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center, Dallas, TX, USA. .
Yates CC; Department of Health Promotions and Development, School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA. .
Stansfield WE; Department of Surgery, University of North Carolina, Chapel Hill, NC, USA. .
Mapanga RF; Cardio-Metabolic Research Group (CMRG), Department of Physiological Sciences, Stellenbosch University, Stellenbosch, 7600, South Africa. .
Essop MF; Cardio-Metabolic Research Group (CMRG), Department of Physiological Sciences, Stellenbosch University, Stellenbosch, 7600, South Africa. .
Muehlbauer MJ; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA. .
Newgard CB; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA. chris.newgard@duke.edu.; Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Duke University Medical Center, Durham, NC, USA. chris.newgard@duke.edu.
Bain JR; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA. .; Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Duke University Medical Center, Durham, NC, USA. .
Willis MS; Department of Pathology & Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA. monte_.; McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA. monte_.
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Źródło:
BMC endocrine disorders [BMC Endocr Disord] 2015 Jul 28; Vol. 15, pp. 36. Date of Electronic Publication: 2015 Jul 28.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Diabetic Cardiomyopathies/*genetics
Diet, High-Fat/*adverse effects
Heart Failure, Systolic/*genetics
Muscle Proteins/*genetics
Myocytes, Cardiac/*metabolism
Adipose Tissue ; Animals ; Body Composition ; Body Weight ; Diabetic Cardiomyopathies/etiology ; Diabetic Cardiomyopathies/metabolism ; Heart Failure, Systolic/etiology ; Heart Failure, Systolic/metabolism ; In Vitro Techniques ; Mice ; Mice, Knockout ; Muscle Proteins/metabolism ; PPAR alpha/metabolism ; PPAR gamma/metabolism ; PPAR-beta/metabolism ; Ubiquitination
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Non-targeted metabolomics analysis of cardiac Muscle Ring Finger-1 (MuRF1), MuRF2, and MuRF3 in vivo reveals novel and redundant metabolic changes.
Autorzy:
Banerjee R; University of North Carolina School of Medicine, Chapel Hill, NC USA.
He J; General Hospital of Ningxia Medical University, Yinchuan, Ningxia, P. R. China; Department of Pathology & Laboratory Medicine, University of North Carolina, Chapel Hill, NC USA.
Spaniel C; Department of Pathology & Laboratory Medicine, University of North Carolina, Chapel Hill, NC USA.
Quintana MT; University of North Carolina School of Medicine, Chapel Hill, NC USA.
Wang Z; University of North Carolina School of Medicine, Chapel Hill, NC USA.
Bain J; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina; Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Duke University Medical Center, Durham, North Carolina.
Newgard CB; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina; Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Duke University Medical Center, Durham, North Carolina.
Muehlbauer MJ; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina.
Willis MS; Department of Pathology & Laboratory Medicine, University of North Carolina, Chapel Hill, NC USA; McAllister Heart Institute, University of North Carolina, Chapel Hill, NC USA.
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Źródło:
Metabolomics : Official journal of the Metabolomic Society [Metabolomics] 2015 Apr; Vol. 11 (2), pp. 312-322. Date of Electronic Publication: 2014 Jul 14.
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
CAPER is vital for energy and redox homeostasis by integrating glucose-induced mitochondrial functions via ERR-α-Gabpa and stress-induced adaptive responses via NF-κB-cMYC.
Autorzy:
Kang YK; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America.
Putluri N; Verna and Marrs McLean Department of Biochemistry and Alkek Center for Molecular Discovery, Baylor College of Medicine, Houston, Texas, United States of America; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America.
Maity S; Verna and Marrs McLean Department of Biochemistry and Alkek Center for Molecular Discovery, Baylor College of Medicine, Houston, Texas, United States of America; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America.
Tsimelzon A; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas, United States of America.
Ilkayeva O; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical School, Durham, North Carolina, United States of America.
Mo Q; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America; Department of Medicine, Baylor College of Medicine, Houston, Texas, United States of America.
Lonard D; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America.
Michailidis G; Department of Statistics, University of Michigan, Ann Arbor, Michigan, United States of America.
Sreekumar A; Verna and Marrs McLean Department of Biochemistry and Alkek Center for Molecular Discovery, Baylor College of Medicine, Houston, Texas, United States of America; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America.
Newgard CB; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical School, Durham, North Carolina, United States of America.
Wang M; Huffington Center on Aging, Baylor College of Medicine, Houston, Texas, United States of America; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America.
Tsai SY; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America.
Tsai MJ; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America.
O'Malley BW; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America.
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Źródło:
PLoS genetics [PLoS Genet] 2015 Apr 01; Vol. 11 (4), pp. e1005116. Date of Electronic Publication: 2015 Apr 01 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Energy Metabolism*
Oxidative Stress*
GA-Binding Protein Transcription Factor/*metabolism
Glucose/*metabolism
Mitochondria/*metabolism
RNA-Binding Proteins/*metabolism
Receptors, Estrogen/*metabolism
Trans-Activators/*metabolism
Adaptation, Physiological ; Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Cell Line ; GA-Binding Protein Transcription Factor/genetics ; Homeostasis ; Humans ; Mice ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Oxidation-Reduction ; Proto-Oncogene Proteins c-myc/genetics ; Proto-Oncogene Proteins c-myc/metabolism ; RNA-Binding Proteins/genetics ; Receptors, Estrogen/genetics ; Trans-Activators/genetics ; ERRalpha Estrogen-Related Receptor
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Effects of HIV infection on the metabolic and hormonal status of children with severe acute malnutrition.
Autorzy:
Mody A; Division of Pediatric Endocrinology and Diabetes, Pediatric Division of Quantitative Sciences, Duke University Medical Center, Durham, North Carolina, United States of America.
Bartz S; Division of Pediatric Endocrinology and Diabetes, Pediatric Division of Quantitative Sciences, Duke University Medical Center, Durham, North Carolina, United States of America.
Hornik CP; Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, United States of America.
Kiyimba T; Mwanamugimu Nutrition Unit, Mulago Hospital Complex, Kampala, Uganda.
Bain J; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States of America.
Muehlbauer M; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States of America.
Kiboneka E; Mwanamugimu Nutrition Unit, Mulago Hospital Complex, Kampala, Uganda.
Stevens R; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States of America.
St Peter JV; Global Research & Development, Long Term Research, PepsiCo, Inc., Purchase, New York, United States of America.
Newgard CB; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States of America.
Bartlett J; Duke Global Health Institute, Duke University Medical Center, Durham, North Carolina, United States of America.
Freemark M; Division of Pediatric Endocrinology and Diabetes, Pediatric Division of Quantitative Sciences, Duke University Medical Center, Durham, North Carolina, United States of America; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States of America; Duke Global Health Institute, Duke University Medical Center, Durham, North Carolina, United States of America.
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Źródło:
PloS one [PLoS One] 2014 Jul 22; Vol. 9 (7), pp. e102233. Date of Electronic Publication: 2014 Jul 22 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Child Nutrition Disorders/*blood
HIV Infections/*blood
Acute Disease ; Adiponectin/blood ; Amino Acids/blood ; Child Nutrition Disorders/mortality ; Child Nutrition Disorders/therapy ; Child Nutrition Disorders/virology ; Child, Preschool ; Female ; HIV Infections/mortality ; Humans ; Infant ; Leptin/blood ; Male ; Treatment Outcome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-25 z 47

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