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Wyświetlanie 1-20 z 95
Tytuł:
Role of cognitive enhancer therapy in Alzheimer's disease with concomitant cerebral white matter disease: findings from a long-term naturalistic study.
Autorzy:
Ng KP; Department of Neurology, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore.
Ng A
Assam P
Heng E
Kandiah N
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Źródło:
Drugs in R&D [Drugs R D] 2014 Sep; Vol. 14 (3), pp. 195-203.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease/*drug therapy
Cerebrovascular Disorders/*drug therapy
Cognition Disorders/*drug therapy
Nootropic Agents/*pharmacology
Aged ; Aged, 80 and over ; Alzheimer Disease/physiopathology ; Cerebrovascular Disorders/etiology ; Cognition Disorders/etiology ; Databases, Factual ; Female ; Follow-Up Studies ; Humans ; Hypertension/epidemiology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Retrospective Studies ; Time Factors ; White Matter/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Is ApoE ɛ 4 a good biomarker for amyloid pathology in late onset Alzheimer's disease?
Autorzy:
Ba M; Department of Neurology, Yuhuangding Hospital Affiliated to Qingdao Medical University, Qingdao, Shandong 264000 People's Republic of China.; McGill Centre for Studies in Aging, McGill University, Douglas Institute, 6825 Lasalle Boul, Montreal, QC H4H 1R3 Canada.
Kong M; Department of Neurology, Yantaishan Hospital, Yantai City, Shandong 264000 People's Republic of China.
Li X; McGill Centre for Studies in Aging, McGill University, Douglas Institute, 6825 Lasalle Boul, Montreal, QC H4H 1R3 Canada.; Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010 People's Republic of China.
Ng KP; McGill Centre for Studies in Aging, McGill University, Douglas Institute, 6825 Lasalle Boul, Montreal, QC H4H 1R3 Canada.; Department of Neurology, National Neuroscience Institute Singapore, Singapore, Singapore.
Rosa-Neto P; McGill Centre for Studies in Aging, McGill University, Douglas Institute, 6825 Lasalle Boul, Montreal, QC H4H 1R3 Canada.
Gauthier S; McGill Centre for Studies in Aging, McGill University, Douglas Institute, 6825 Lasalle Boul, Montreal, QC H4H 1R3 Canada.
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Źródło:
Translational neurodegeneration [Transl Neurodegener] 2016 Nov 16; Vol. 5, pp. 20. Date of Electronic Publication: 2016 Nov 16 (Print Publication: 2016).
Typ publikacji:
Review; Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Monoamine oxidase B inhibitor, selegiline, reduces F-THK5351 uptake in the human brain.
Autorzy:
Ng KP; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, 6825 LaSalle Boulevard, Verdun, Québec, H4H 1R3, Canada.; Department of Neurology, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore.; Alzheimer's Disease Research Unit, The McGill University Research Centre for Studies in Aging, McGill University, 6825 LaSalle Boulevard, Verdun, Québec, H4H 1R3, Canada.
Pascoal TA; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, 6825 LaSalle Boulevard, Verdun, Québec, H4H 1R3, Canada.
Mathotaarachchi S; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, 6825 LaSalle Boulevard, Verdun, Québec, H4H 1R3, Canada.
Therriault J; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, 6825 LaSalle Boulevard, Verdun, Québec, H4H 1R3, Canada.
Kang MS; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, 6825 LaSalle Boulevard, Verdun, Québec, H4H 1R3, Canada.
Shin M; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, 6825 LaSalle Boulevard, Verdun, Québec, H4H 1R3, Canada.
Guiot MC; Montreal Neurological Institute/Hospital, Department of Pathology, McGill University Hospital Centre, 3801 University Street, Montreal, Québec, H3A 2B4, Canada.
Guo Q; AbbVie Inc., 1 North Waukegan Road, North Chicago, IL, USA.
Harada R; Department of Pharmacology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan.
Comley RA; AbbVie Inc., 1 North Waukegan Road, North Chicago, IL, USA.
Massarweh G; McConnell Brain Imaging Centre, McGill University, 3801 University Street, Montreal, Québec, H3A 2B4, Canada.
Soucy JP; McConnell Brain Imaging Centre, McGill University, 3801 University Street, Montreal, Québec, H3A 2B4, Canada.
Okamura N; Division of Pharmacology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, 981-8558, Japan.
Gauthier S; Alzheimer's Disease Research Unit, The McGill University Research Centre for Studies in Aging, McGill University, 6825 LaSalle Boulevard, Verdun, Québec, H4H 1R3, Canada.
Rosa-Neto P; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, 6825 LaSalle Boulevard, Verdun, Québec, H4H 1R3, Canada. .; Alzheimer's Disease Research Unit, The McGill University Research Centre for Studies in Aging, McGill University, 6825 LaSalle Boulevard, Verdun, Québec, H4H 1R3, Canada. .; Montreal Neurological Institute, 3801 University Street, Montreal, Québec, H3A 2B4, Canada. .; Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, Québec, H3A 2B4, Canada. .
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Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2017 Mar 31; Vol. 9 (1), pp. 25. Date of Electronic Publication: 2017 Mar 31.
Typ publikacji:
Journal Article
MeSH Terms:
Aminopyridines/*pharmacokinetics
Brain/*diagnostic imaging
Fluorine Radioisotopes/*pharmacokinetics
Monoamine Oxidase/*metabolism
Monoamine Oxidase Inhibitors/*pharmacology
Quinolines/*pharmacokinetics
Selegiline/*pharmacology
Aged ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/metabolism ; Autoradiography ; Binding, Competitive ; Brain/drug effects ; Brain/metabolism ; Cognitive Dysfunction/diagnostic imaging ; Cognitive Dysfunction/metabolism ; Drug Interactions ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Positron-Emission Tomography ; Radiopharmaceuticals ; Supranuclear Palsy, Progressive/diagnostic imaging ; Supranuclear Palsy, Progressive/metabolism ; tau Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
In vivo quantification of neurofibrillary tangles with [ F]MK-6240.
Autorzy:
Pascoal TA; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, 6825 LaSalle Boulevard, Verdun, QC, H4H 1R3, Canada.; Montreal Neurological Institute, 3801 University Street, Montreal, QC, H3A 2B4, Canada.
Shin M; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, 6825 LaSalle Boulevard, Verdun, QC, H4H 1R3, Canada.
Kang MS; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, 6825 LaSalle Boulevard, Verdun, QC, H4H 1R3, Canada.; Montreal Neurological Institute, 3801 University Street, Montreal, QC, H3A 2B4, Canada.
Chamoun M; Montreal Neurological Institute, 3801 University Street, Montreal, QC, H3A 2B4, Canada.
Chartrand D; Montreal Neurological Institute, 3801 University Street, Montreal, QC, H3A 2B4, Canada.
Mathotaarachchi S; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, 6825 LaSalle Boulevard, Verdun, QC, H4H 1R3, Canada.; Montreal Neurological Institute, 3801 University Street, Montreal, QC, H3A 2B4, Canada.
Bennacef I; Translational Biomarkers, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA, 19486, USA.
Therriault J; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, 6825 LaSalle Boulevard, Verdun, QC, H4H 1R3, Canada.
Ng KP; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, 6825 LaSalle Boulevard, Verdun, QC, H4H 1R3, Canada.
Hopewell R; Montreal Neurological Institute, 3801 University Street, Montreal, QC, H3A 2B4, Canada.
Bouhachi R; Montreal Neurological Institute, 3801 University Street, Montreal, QC, H3A 2B4, Canada.
Hsiao HH; Montreal Neurological Institute, 3801 University Street, Montreal, QC, H3A 2B4, Canada.
Benedet AL; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, 6825 LaSalle Boulevard, Verdun, QC, H4H 1R3, Canada.
Soucy JP; Montreal Neurological Institute, 3801 University Street, Montreal, QC, H3A 2B4, Canada.
Massarweh G; Montreal Neurological Institute, 3801 University Street, Montreal, QC, H3A 2B4, Canada.
Gauthier S; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, 6825 LaSalle Boulevard, Verdun, QC, H4H 1R3, Canada.
Rosa-Neto P; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, 6825 LaSalle Boulevard, Verdun, QC, H4H 1R3, Canada. .; Montreal Neurological Institute, 3801 University Street, Montreal, QC, H3A 2B4, Canada. .; Douglas Hospital, McGill University, 6875 La Salle Blvd-FBC room 3149, Montreal, QC, H4H 1R3, Canada. .
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Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2018 Jul 31; Vol. 10 (1), pp. 74. Date of Electronic Publication: 2018 Jul 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease/*pathology
Brain/*diagnostic imaging
Brain/*drug effects
Isoquinolines/*pharmacokinetics
Neurofibrillary Tangles/*pathology
Adult ; Age Factors ; Aged ; Alzheimer Disease/diagnostic imaging ; Autopsy ; Autoradiography ; Brain/pathology ; Female ; Fluorodeoxyglucose F18/pharmacokinetics ; Humans ; Imaging, Three-Dimensional ; In Vitro Techniques ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neurofibrillary Tangles/metabolism ; Positron-Emission Tomography ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cerebrospinal fluid phosphorylated tau, visinin-like protein-1, and chitinase-3-like protein 1 in mild cognitive impairment and Alzheimer's disease.
Autorzy:
Zhang H; 1Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016 China.
Ng KP; 2Department of Neurology, National Neuroscience Institute, Singapore, Singapore.
Therriault J; 3The McGill University Research Centre for Studies in Aging, McGill University, Montreal, Canada.
Kang MS; 3The McGill University Research Centre for Studies in Aging, McGill University, Montreal, Canada.
Pascoal TA; 3The McGill University Research Centre for Studies in Aging, McGill University, Montreal, Canada.
Rosa-Neto P; 3The McGill University Research Centre for Studies in Aging, McGill University, Montreal, Canada.
Gauthier S; 3The McGill University Research Centre for Studies in Aging, McGill University, Montreal, Canada.
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Corporate Authors:
Alzheimer’s Disease Neuroimaging Initiative
Źródło:
Translational neurodegeneration [Transl Neurodegener] 2018 Sep 10; Vol. 7, pp. 23. Date of Electronic Publication: 2018 Sep 10 (Print Publication: 2018).
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Suicidal ideation is common in autosomal dominant Alzheimer's disease at-risk persons.
Autorzy:
Ng, Kok Pin (AUTHOR)
Richard‐Devantoy, Stéphane (AUTHOR)
Bertrand, Josie‐Anne (AUTHOR)
Jiang, Lai (AUTHOR)
Pascoal, Tharick A. (AUTHOR)
Mathotaarachchi, Sulantha (AUTHOR)
Therriault, Joseph (AUTHOR)
Yatawara, Chathuri (AUTHOR)
Kandiah, Nagaendran (AUTHOR)
Greenwood, Celia M.T. (AUTHOR)
Rosa‐Neto, Pedro (AUTHOR)
Gauthier, Serge (AUTHOR)
Richard-Devantoy, Stéphane (AUTHOR)
Bertrand, Josie-Anne (AUTHOR)
Rosa-Neto, Pedro (AUTHOR)
Dominantly Inherited Alzheimer Network (CORPORATE AUTHOR)
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Źródło:
International Journal of Geriatric Psychiatry. Jan2020, Vol. 35 Issue 1, p60-68. 9p. 3 Charts, 1 Graph.
Czasopismo naukowe
Szczegóły
Tytuł:
Neuropsychiatric symptoms are early indicators of an upcoming metabolic decline in Alzheimer's disease.
Autorzy:
Ng KP; Alzheimer's Disease Research Unit, McGill Centre for Studies in Aging, McGill University, Montréal, Québec, Canada.; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Montreal, Canada.; Department of Neurology, National Neuroscience Institute, Singapore City, Singapore.
Pascoal TA; Alzheimer's Disease Research Unit, McGill Centre for Studies in Aging, McGill University, Montréal, Québec, Canada.; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Montreal, Canada.
Mathotaarachchi S; Alzheimer's Disease Research Unit, McGill Centre for Studies in Aging, McGill University, Montréal, Québec, Canada.; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Montreal, Canada.
Chan YH; Biostatistics Unit, Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore.
Jiang L; Lady Davis Institute, McGill University, Montreal, Canada.; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada.
Therriault J; Alzheimer's Disease Research Unit, McGill Centre for Studies in Aging, McGill University, Montréal, Québec, Canada.; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Montreal, Canada.
Benedet AL; Alzheimer's Disease Research Unit, McGill Centre for Studies in Aging, McGill University, Montréal, Québec, Canada.; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Montreal, Canada.
Shin M; Alzheimer's Disease Research Unit, McGill Centre for Studies in Aging, McGill University, Montréal, Québec, Canada.; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Montreal, Canada.
Kandiah N; Department of Neurology, National Neuroscience Institute, Singapore City, Singapore.
Greenwood CMT; Lady Davis Institute, McGill University, Montreal, Canada.; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada.
Rosa-Neto P; Alzheimer's Disease Research Unit, McGill Centre for Studies in Aging, McGill University, Montréal, Québec, Canada.; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Montreal, Canada.
Gauthier S; Alzheimer's Disease Research Unit, McGill Centre for Studies in Aging, McGill University, Montréal, Québec, Canada. .; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Montreal, Canada. .
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Corporate Authors:
Dominantly Inherited Alzheimer Network
Źródło:
Translational neurodegeneration [Transl Neurodegener] 2021 Jan 04; Vol. 10 (1), pp. 1. Date of Electronic Publication: 2021 Jan 04.
Typ publikacji:
Journal Article; Observational Study
MeSH Terms:
Alzheimer Disease/*metabolism
Mental Disorders/*etiology
Mental Disorders/*psychology
Nervous System Diseases/*etiology
Nervous System Diseases/*psychology
Adult ; Age of Onset ; Aged ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/genetics ; Disease Progression ; Factor Analysis, Statistical ; Female ; Fluorodeoxyglucose F18 ; Heterozygote ; Humans ; Longitudinal Studies ; Male ; Mental Disorders/diagnostic imaging ; Middle Aged ; Mutation ; Nervous System Diseases/diagnostic imaging ; Neuropsychological Tests ; Positron-Emission Tomography ; Radiopharmaceuticals
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Associations of AT(N) biomarkers with neuropsychiatric symptoms in preclinical Alzheimer's disease and cognitively unimpaired individuals.
Autorzy:
Ng KP; Department of Neurology, National Neuroscience Institute, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore.; Lee Kong Chian School of Medicine - Imperial College London, Nanyang Technological University, Singapore, Singapore.
Chiew H; Department of Neurology, National Neuroscience Institute, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore.; Lee Kong Chian School of Medicine - Imperial College London, Nanyang Technological University, Singapore, Singapore.
Rosa-Neto P; The McGill University Research Centre for Studies in Aging, Montreal, Canada.
Kandiah N; Department of Neurology, National Neuroscience Institute, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore.; Lee Kong Chian School of Medicine - Imperial College London, Nanyang Technological University, Singapore, Singapore.
Ismail Z; Hotchkiss Brain Institute and O'Brien Institute for Public Health; Departments of Psychiatry, Clinical Neurosciences, and Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.
Gauthier S; The McGill University Research Centre for Studies in Aging, Montreal, Canada. .
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Źródło:
Translational neurodegeneration [Transl Neurodegener] 2021 Mar 31; Vol. 10 (1), pp. 11. Date of Electronic Publication: 2021 Mar 31.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Alzheimer Disease/*blood
Alzheimer Disease/*psychology
Amyloid beta-Protein Precursor/*analysis
Mental Disorders/*psychology
Nervous System Diseases/*psychology
tau Proteins/*analysis
Cognitive Dysfunction/blood ; Cognitive Dysfunction/psychology ; Humans ; Prodromal Symptoms
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 95

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