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Wyświetlanie 1-10 z 10
Tytuł:
p21-Activated Kinases 1, 2 and 4 in Endometrial Cancers: Effects on Clinical Outcomes and Cell Proliferation.
Autorzy:
Siu MK; Department of Pathology, The University of Hong Kong, Hong Kong, HKSAR, China; Department of Obstetrics and Gynaecology, The University of Hong Kong, Hong Kong, HKSAR, China.
Kong DS; Department of Pathology, The University of Hong Kong, Hong Kong, HKSAR, China.
Ngai SY; Department of Pathology, The University of Hong Kong, Hong Kong, HKSAR, China.
Chan HY; Department of Pathology, The University of Hong Kong, Hong Kong, HKSAR, China.
Jiang L; Department of Pathology, The University of Hong Kong, Hong Kong, HKSAR, China.
Wong ES; Department of Pathology, The University of Hong Kong, Hong Kong, HKSAR, China.
Liu SS; Department of Obstetrics and Gynaecology, The University of Hong Kong, Hong Kong, HKSAR, China.
Chan KK; Department of Obstetrics and Gynaecology, The University of Hong Kong, Hong Kong, HKSAR, China.
Ngan HY; Department of Obstetrics and Gynaecology, The University of Hong Kong, Hong Kong, HKSAR, China.
Cheung AN; Department of Pathology, The University of Hong Kong, Hong Kong, HKSAR, China.
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Źródło:
PloS one [PLoS One] 2015 Jul 28; Vol. 10 (7), pp. e0133467. Date of Electronic Publication: 2015 Jul 28 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Endometrial Neoplasms/*metabolism
Endometrial Neoplasms/*pathology
p21-Activated Kinases/*metabolism
Adult ; Aged ; Aged, 80 and over ; Cell Line, Tumor ; Cell Proliferation ; Cytoplasm/metabolism ; Endometrial Neoplasms/mortality ; Female ; Humans ; Kaplan-Meier Estimate ; Middle Aged ; Phosphorylation ; Young Adult ; p21-Activated Kinases/genetics
Czasopismo naukowe
Tytuł:
Overexpression of forkhead box protein M1 (FOXM1) in ovarian cancer correlates with poor patient survival and contributes to paclitaxel resistance.
Autorzy:
Zhao F; Department of Pathology, The University of Hong Kong, HKSAR, China; Department of Surgery and Cancer, Imperial College London, London, United Kingdom.
Siu MK; Obstetrics and Gynaecology, The University of Hong Kong, HKSAR, China.
Jiang L; Department of Pathology, West China Hospital, Sichuang University, Chengdu, China.
Tam KF; Department of Pathology, The University of Hong Kong, HKSAR, China.
Ngan HY; Obstetrics and Gynaecology, The University of Hong Kong, HKSAR, China.
Le XF; Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Texas, United States of America.
Wong OG; Department of Pathology, The University of Hong Kong, HKSAR, China.
Wong ES; Department of Pathology, The University of Hong Kong, HKSAR, China.
Gomes AR; Department of Surgery and Cancer, Imperial College London, London, United Kingdom.
Bella L; Department of Surgery and Cancer, Imperial College London, London, United Kingdom.
Khongkow P; Department of Surgery and Cancer, Imperial College London, London, United Kingdom.
Lam EW; Department of Surgery and Cancer, Imperial College London, London, United Kingdom.
Cheung AN; Department of Pathology, The University of Hong Kong, HKSAR, China; Department of Pathology, The University of Hong Kong -Shenzhen Hospital, Shenzhen, China.
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Źródło:
PloS one [PLoS One] 2014 Nov 20; Vol. 9 (11), pp. e113478. Date of Electronic Publication: 2014 Nov 20 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents, Phytogenic/*pharmacology
Apoptosis/*drug effects
Forkhead Transcription Factors/*metabolism
Ovarian Neoplasms/*pathology
Paclitaxel/*pharmacology
Antineoplastic Agents, Phytogenic/therapeutic use ; Cell Line, Tumor ; Cell Movement ; Disease-Free Survival ; Down-Regulation/drug effects ; Drug Resistance, Neoplasm ; Female ; Follow-Up Studies ; Forkhead Box Protein M1 ; Forkhead Transcription Factors/antagonists & inhibitors ; Forkhead Transcription Factors/genetics ; G2 Phase Cell Cycle Checkpoints ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Kinesins/genetics ; Neoplasm Staging ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/mortality ; Paclitaxel/therapeutic use ; Prognosis ; Real-Time Polymerase Chain Reaction
Czasopismo naukowe
Tytuł:
AMPK activators suppress cervical cancer cell growth through inhibition of DVL3 mediated Wnt/β-catenin signaling activity.
Autorzy:
Kwan HT; Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, PR China.
Chan DW
Cai PC
Mak CS
Yung MM
Leung TH
Wong OG
Cheung AN
Ngan HY
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Źródło:
PloS one [PLoS One] 2013; Vol. 8 (1), pp. e53597. Date of Electronic Publication: 2013 Jan 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
AMP-Activated Protein Kinases/*metabolism
Adaptor Proteins, Signal Transducing/*metabolism
Phosphoproteins/*metabolism
Uterine Cervical Neoplasms/*enzymology
Wnt Proteins/*metabolism
beta Catenin/*metabolism
Cell Line, Tumor ; Cell Proliferation ; Dishevelled Proteins ; Dose-Response Relationship, Drug ; Enzyme Activation ; Female ; HEK293 Cells ; HeLa Cells ; Humans ; Immunohistochemistry/methods ; Plasmids/metabolism ; Signal Transduction ; Time Factors ; Uterine Cervical Neoplasms/metabolism
Czasopismo naukowe
Tytuł:
Paradoxical impact of two folate receptors, FRα and RFC, in ovarian cancer: effect on cell proliferation, invasion and clinical outcome.
Autorzy:
Siu MK; Department of Pathology, University of Hong Kong, Hong Kong, Special Administrative Region of China. />Kong DS
Chan HY
Wong ES
Ip PP
Jiang L
Ngan HY
Le XF
Cheung AN
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Źródło:
PloS one [PLoS One] 2012; Vol. 7 (11), pp. e47201. Date of Electronic Publication: 2012 Nov 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation, Neoplastic*
Folate Receptor 1/*genetics
Ovarian Neoplasms/*genetics
Ovarian Neoplasms/*pathology
Reduced Folate Carrier Protein/*genetics
Adult ; Aged ; Aged, 80 and over ; Cadherins/genetics ; Cadherins/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Disease-Free Survival ; Female ; Folate Receptor 1/metabolism ; Humans ; Middle Aged ; Neoplasm Invasiveness/genetics ; Neoplasm Invasiveness/pathology ; Ovarian Neoplasms/metabolism ; Ovarian Neoplasms/therapy ; Ovary/metabolism ; Ovary/pathology ; Promoter Regions, Genetic ; RNA, Messenger/genetics ; Reduced Folate Carrier Protein/metabolism ; Up-Regulation ; Young Adult
Czasopismo naukowe
Tytuł:
Targeting GRB7/ERK/FOXM1 signaling pathway impairs aggressiveness of ovarian cancer cells.
Autorzy:
Chan DW; Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, PR China. />Hui WW
Cai PC
Liu MX
Yung MM
Mak CS
Leung TH
Chan KK
Ngan HY
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Źródło:
PloS one [PLoS One] 2012; Vol. 7 (12), pp. e52578. Date of Electronic Publication: 2012 Dec 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Molecular Targeted Therapy*
Signal Transduction*
Extracellular Signal-Regulated MAP Kinases/*antagonists & inhibitors
Forkhead Transcription Factors/*antagonists & inhibitors
GRB7 Adaptor Protein/*metabolism
Ovarian Neoplasms/*enzymology
Ovarian Neoplasms/*pathology
Animals ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Female ; Forkhead Box Protein M1 ; Forkhead Transcription Factors/metabolism ; Humans ; Mice ; Mice, Inbred BALB C ; Neoplasm Invasiveness ; Phosphorylation ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł:
Increased expression of PITX2 transcription factor contributes to ovarian cancer progression.
Autorzy:
Fung FK; Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China.
Chan DW
Liu VW
Leung TH
Cheung AN
Ngan HY
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Źródło:
PloS one [PLoS One] 2012; Vol. 7 (5), pp. e37076. Date of Electronic Publication: 2012 May 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Homeodomain Proteins/*biosynthesis
Ovarian Neoplasms/*metabolism
Ovarian Neoplasms/*pathology
Transcription Factors/*biosynthesis
Animals ; Cell Cycle/genetics ; Cell Growth Processes/physiology ; Cell Line, Tumor ; Cell Movement/genetics ; Cyclin D1/genetics ; Cyclin D1/metabolism ; Disease Progression ; Female ; Gene Expression Regulation, Neoplastic ; Genes, myc/genetics ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Humans ; Mice ; Neoplasm Invasiveness ; Ovarian Neoplasms/genetics ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Up-Regulation ; Wnt Proteins/genetics ; Wnt Proteins/metabolism ; beta Catenin/genetics ; beta Catenin/metabolism ; Homeobox Protein PITX2
Czasopismo naukowe
Tytuł:
TAp73-mediated the activation of c-Jun N-terminal kinase enhances cellular chemosensitivity to cisplatin in ovarian cancer cells.
Autorzy:
Zhang P; Department of Obstetrics and Gynecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
Liu SS
Ngan HY
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Źródło:
PloS one [PLoS One] 2012; Vol. 7 (8), pp. e42985. Date of Electronic Publication: 2012 Aug 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents/*pharmacology
Cisplatin/*pharmacology
DNA-Binding Proteins/*genetics
JNK Mitogen-Activated Protein Kinases/*metabolism
Nuclear Proteins/*genetics
Ovarian Neoplasms/*genetics
Ovarian Neoplasms/*metabolism
Tumor Suppressor Proteins/*genetics
Apoptosis/drug effects ; Apoptosis/genetics ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; DNA-Binding Proteins/metabolism ; Drug Resistance, Neoplasm/genetics ; Enzyme Activation/genetics ; Female ; Gene Expression ; Gene Expression Regulation, Neoplastic ; Humans ; JNK Mitogen-Activated Protein Kinases/antagonists & inhibitors ; JNK Mitogen-Activated Protein Kinases/genetics ; Nuclear Proteins/metabolism ; RNA Interference ; Signal Transduction/drug effects ; Tumor Protein p73 ; Tumor Suppressor Proteins/metabolism
Czasopismo naukowe
Tytuł:
Prevalence and risk factors of Human Papillomavirus (HPV) infection in southern Chinese women - a population-based study.
Autorzy:
Liu SS; Department of Obstetrics & Gynaecology, The University of Hong Kong, Hong Kong, China.
Chan KY
Leung RC
Chan KK
Tam KF
Luk MH
Lo SS
Fong DY
Cheung AN
Lin ZQ
Ngan HY
Pokaż więcej
Źródło:
PloS one [PLoS One] 2011 May 03; Vol. 6 (5), pp. e19244. Date of Electronic Publication: 2011 May 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Papillomavirus Infections/*epidemiology
Papillomavirus Infections/*virology
Adult ; Aged ; Asian People ; Cervix Uteri/virology ; China ; Cohort Studies ; Cross-Sectional Studies ; DNA, Viral/genetics ; Female ; Hong Kong ; Humans ; Middle Aged ; Papillomavirus Infections/ethnology ; Prevalence ; Risk Factors
Czasopismo naukowe
Tytuł:
Aberrant activation of ERK/FOXM1 signaling cascade triggers the cell migration/invasion in ovarian cancer cells.
Autorzy:
Lok GT; Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
Chan DW
Liu VW
Hui WW
Leung TH
Yao KM
Ngan HY
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Źródło:
PloS one [PLoS One] 2011; Vol. 6 (8), pp. e23790. Date of Electronic Publication: 2011 Aug 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Movement*
Signal Transduction*
Extracellular Signal-Regulated MAP Kinases/*metabolism
Forkhead Transcription Factors/*metabolism
Blotting, Western ; Butadienes/pharmacology ; Cell Line ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/pharmacology ; Extracellular Signal-Regulated MAP Kinases/genetics ; Female ; Forkhead Box Protein M1 ; Forkhead Transcription Factors/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Immunohistochemistry ; Matrix Metalloproteinase 9/genetics ; Matrix Metalloproteinase 9/metabolism ; Neoplasm Invasiveness ; Nitriles/pharmacology ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/metabolism ; Ovarian Neoplasms/pathology ; Phosphoproteins/genetics ; Phosphoproteins/metabolism ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Receptors, Urokinase Plasminogen Activator/genetics ; Receptors, Urokinase Plasminogen Activator/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Thiostrepton/pharmacology ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism
Czasopismo naukowe
    Wyświetlanie 1-10 z 10

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