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Tytuł :
The specificity of asciminib, a potential treatment for chronic myeloid leukemia, as a myristate-pocket binding ABL inhibitor and analysis of its interactions with mutant forms of BCR-ABL1 kinase.
Autorzy :
Manley PW; Novartis Institutes for Biomedical Research, Novartis Pharma AG, CH-4002 Basel, Switzerland. Electronic address: .
Barys L; Novartis Institutes for Biomedical Research, Novartis Pharma AG, CH-4002 Basel, Switzerland.
Cowan-Jacob SW; Novartis Institutes for Biomedical Research, Novartis Pharma AG, CH-4002 Basel, Switzerland.
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Źródło :
Leukemia research [Leuk Res] 2020 Nov; Vol. 98, pp. 106458. Date of Electronic Publication: 2020 Sep 29.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Fusion Proteins, bcr-abl*/antagonists & inhibitors
Fusion Proteins, bcr-abl*/genetics
Fusion Proteins, bcr-abl*/metabolism
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/drug therapy
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/enzymology
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/genetics
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/pathology
Mutation*
Pyrazoles*/pharmacokinetics
Pyrazoles*/therapeutic use
Cell Proliferation/*drug effects
Drug Resistance, Neoplasm/*drug effects
Niacinamide/*analogs & derivatives
Binding Sites ; Drug Resistance, Neoplasm/genetics ; Humans ; Niacinamide/pharmacokinetics ; Niacinamide/therapeutic use
Czasopismo naukowe
Tytuł :
Alleviation of brain injury by applying TGN-020 in the supraoptic nucleus via inhibiting vasopressin neurons in rats of focal ischemic stroke.
Autorzy :
Cui D; Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Jia S; Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Li T; Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Li D; Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Wang X; Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Liu X; Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Wang YF; Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jan 01; Vol. 264, pp. 118683. Date of Electronic Publication: 2020 Oct 28.
Typ publikacji :
Journal Article
MeSH Terms :
Brain Injuries/*metabolism
Ischemic Stroke/*metabolism
Neurons/*metabolism
Niacinamide/*analogs & derivatives
Supraoptic Nucleus/*metabolism
Thiadiazoles/*administration & dosage
Vasopressins/*metabolism
Animals ; Brain Injuries/drug therapy ; Ischemic Stroke/drug therapy ; Male ; Microinjections/methods ; Neurons/drug effects ; Niacinamide/administration & dosage ; Rats ; Rats, Wistar ; Supraoptic Nucleus/drug effects ; Vasopressins/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Nicotinamide riboside reduces cardiometabolic risk factors and modulates cardiac oxidative stress in obese Wistar rats under caloric restriction.
Autorzy :
de Castro JM; Programa de Pós-Graduação em Ciências Biológicas (PPG): Farmacologia e Terapêutica - Instituto de Ciências Básicas da Saúde (ICBS) - Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil; Laboratório de Farmacologia da Dor e Neuromodulação: Investigações Pré-clínicas - Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil.
Assumpção JAF; Laboratório de Farmacologia da Dor e Neuromodulação: Investigações Pré-clínicas - Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil; Programa de Pós-Graduação em Medicina: Ciências Médicas - Faculdade de Medicina - UFRGS, Porto Alegre, RS, Brazil.
Stein DJ; Laboratório de Farmacologia da Dor e Neuromodulação: Investigações Pré-clínicas - Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil; Programa de Pós-Graduação em Medicina: Ciências Médicas - Faculdade de Medicina - UFRGS, Porto Alegre, RS, Brazil.
Toledo RS; Programa de Pós-Graduação em Ciências Biológicas (PPG): Farmacologia e Terapêutica - Instituto de Ciências Básicas da Saúde (ICBS) - Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil; Laboratório de Farmacologia da Dor e Neuromodulação: Investigações Pré-clínicas - Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil.
da Silva LS; Laboratório de Farmacologia da Dor e Neuromodulação: Investigações Pré-clínicas - Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil; Programa de Pós-Graduação em Medicina: Ciências Médicas - Faculdade de Medicina - UFRGS, Porto Alegre, RS, Brazil.
Caumo W; Programa de Pós-Graduação em Medicina: Ciências Médicas - Faculdade de Medicina - UFRGS, Porto Alegre, RS, Brazil.
Carraro CC; Laboratório de Fisiologia Cardiovascular e Espécies Reativas de Oxigênio, Departamento de Fisiologia - ICBS - UFRGS, Porto Alegre, RS, Brazil.
da Rosa Araujo AS; Laboratório de Fisiologia Cardiovascular e Espécies Reativas de Oxigênio, Departamento de Fisiologia - ICBS - UFRGS, Porto Alegre, RS, Brazil.
Torres ILS; Programa de Pós-Graduação em Ciências Biológicas (PPG): Farmacologia e Terapêutica - Instituto de Ciências Básicas da Saúde (ICBS) - Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil; Laboratório de Farmacologia da Dor e Neuromodulação: Investigações Pré-clínicas - Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil; Programa de Pós-Graduação em Medicina: Ciências Médicas - Faculdade de Medicina - UFRGS, Porto Alegre, RS, Brazil. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Dec 15; Vol. 263, pp. 118596. Date of Electronic Publication: 2020 Oct 17.
Typ publikacji :
Journal Article
MeSH Terms :
Caloric Restriction*
Niacinamide/*analogs & derivatives
Obesity/*complications
Oxidative Stress/*drug effects
Animals ; Antioxidants/metabolism ; Cardiometabolic Risk Factors ; Insulin Resistance ; Male ; Niacinamide/pharmacology ; Rats ; Rats, Wistar ; Thiobarbituric Acid Reactive Substances/metabolism
Czasopismo naukowe
Tytuł :
Nature-inspired remodeling of (aza)indoles to meta-aminoaryl nicotinates for late-stage conjugation of vitamin B 3 to (hetero)arylamines.
Autorzy :
Varun BV; CRI Center for Chemical Proteomics, Department of Chemistry, Seoul National University, Seoul, 08826, Republic of Korea.
Vaithegi K; CRI Center for Chemical Proteomics, Department of Chemistry, Seoul National University, Seoul, 08826, Republic of Korea.
Yi S; CRI Center for Chemical Proteomics, Department of Chemistry, Seoul National University, Seoul, 08826, Republic of Korea.
Park SB; CRI Center for Chemical Proteomics, Department of Chemistry, Seoul National University, Seoul, 08826, Republic of Korea. .
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Źródło :
Nature communications [Nat Commun] 2020 Dec 09; Vol. 11 (1), pp. 6308. Date of Electronic Publication: 2020 Dec 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amines/*chemical synthesis
Biomimetics/*methods
Chemistry Techniques, Synthetic/*methods
Niacin/*chemical synthesis
Niacinamide/*chemical synthesis
Aza Compounds/chemical synthesis ; Cyclization ; Feasibility Studies ; Indoles/chemical synthesis ; Molecular Structure ; Niacin/analogs & derivatives ; Niacinamide/analogs & derivatives
Czasopismo naukowe
Tytuł :
Imatinib is not a potent anti-SARS-CoV-2 drug.
Autorzy :
Zhao H; Huntsman Cancer Institute, The University of Utah, Salt Lake City, UT, USA.
Mendenhall M; Institute for Antiviral Research, Utah State University, Logan, UT, USA.
Deininger MW; Huntsman Cancer Institute, The University of Utah, Salt Lake City, UT, USA. .; Division of Hematology and Hematologic Malignancies, The University of Utah, Salt Lake City, UT, USA. .
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Źródło :
Leukemia [Leukemia] 2020 Nov; Vol. 34 (11), pp. 3085-3087. Date of Electronic Publication: 2020 Sep 30.
Typ publikacji :
Letter; Research Support, N.I.H., Extramural
MeSH Terms :
Antiviral Agents/*pharmacology
Betacoronavirus/*drug effects
Imatinib Mesylate/*pharmacology
Niacinamide/*analogs & derivatives
Protein Kinase Inhibitors/*pharmacology
Pyrazoles/*pharmacology
Betacoronavirus/growth & development ; Betacoronavirus/pathogenicity ; COVID-19 ; Caco-2 Cells ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology ; Drug Repositioning ; Humans ; Inhibitory Concentration 50 ; Niacinamide/pharmacology ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/virology ; Randomized Controlled Trials as Topic ; SARS-CoV-2 ; Virus Internalization/drug effects ; Virus Replication/drug effects
Raport
Tytuł :
Development of PSMA-1007-Related Series of F-Labeled Glu-Ureido-Type PSMA Inhibitors.
Autorzy :
Cardinale J; Division of Radiopharmaceutical Chemistry, German Cancer Research Center, INF 280, 69120 Heidelberg, Germany.
Roscher M; Division of Radiopharmaceutical Chemistry, German Cancer Research Center, INF 280, 69120 Heidelberg, Germany.
Schäfer M; Division of Radiopharmaceutical Chemistry, German Cancer Research Center, INF 280, 69120 Heidelberg, Germany.
Geerlings M; Division of Radiopharmaceutical Chemistry, German Cancer Research Center, INF 280, 69120 Heidelberg, Germany.
Benešová M; Division of Radiopharmaceutical Chemistry, German Cancer Research Center, INF 280, 69120 Heidelberg, Germany.
Bauder-Wüst U; Division of Radiopharmaceutical Chemistry, German Cancer Research Center, INF 280, 69120 Heidelberg, Germany.
Remde Y; Division of Radiopharmaceutical Chemistry, German Cancer Research Center, INF 280, 69120 Heidelberg, Germany.
Eder M; Division of Radiopharmaceutical Chemistry, German Cancer Research Center, INF 280, 69120 Heidelberg, Germany.
Nováková Z; Laboratory of Structural Biology, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Prumyslova 595, 252 50 Vestec, Czech Republic.
Motlová L; Laboratory of Structural Biology, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Prumyslova 595, 252 50 Vestec, Czech Republic.
Barinka C; Laboratory of Structural Biology, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Prumyslova 595, 252 50 Vestec, Czech Republic.
Giesel FL; Department of Nuclear Medicine, University Hospital Heidelberg, INF 400, 69120 Heidelberg, Germany.
Kopka K; Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, 01328 Dresden, Germany.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Oct 08; Vol. 63 (19), pp. 10897-10907. Date of Electronic Publication: 2020 Sep 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Fluorine Radioisotopes/*chemistry
Glutamate Carboxypeptidase II/*antagonists & inhibitors
Niacinamide/*analogs & derivatives
Oligopeptides/*chemistry
Antigens, Surface ; Humans ; Ligands ; Male ; Niacinamide/chemistry ; Niacinamide/pharmacology ; Oligopeptides/pharmacology ; Positron-Emission Tomography ; Prostatic Neoplasms/diagnostic imaging ; Radiopharmaceuticals/pharmacology
Czasopismo naukowe
Tytuł :
Investigation of Potential Drug-Drug Interactions between Peficitinib (ASP015K) and Methotrexate in Patients with Rheumatoid Arthritis.
Autorzy :
Zhu T; Astellas Pharma Global Development, Northbrook, IL, USA. .
Moy S; Astellas Research Institute of America, LLC, Northbrook, IL, USA.
Valluri U; Astellas Pharma Global Development, Northbrook, IL, USA.
Cao Y; Astellas Pharma Global Development, Northbrook, IL, USA.
Zhang W; Astellas Pharma Global Development, Northbrook, IL, USA.
Sawamoto T; Astellas Pharma Inc., Tsukuba, Ibaraki, Japan.
Chindalore V; Pinnacle Research Group/Anniston Medical Clinic, Anniston, AL, USA.
Akinlade B; Astellas Pharma Global Development, Northbrook, IL, USA.; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA.
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Źródło :
Clinical drug investigation [Clin Drug Investig] 2020 Sep; Vol. 40 (9), pp. 827-838.
Typ publikacji :
Clinical Trial, Phase I; Journal Article
MeSH Terms :
Adamantane/*analogs & derivatives
Antirheumatic Agents/*therapeutic use
Arthritis, Rheumatoid/*drug therapy
Methotrexate/*therapeutic use
Niacinamide/*analogs & derivatives
Adamantane/administration & dosage ; Adamantane/pharmacokinetics ; Adamantane/therapeutic use ; Adult ; Antirheumatic Agents/administration & dosage ; Antirheumatic Agents/pharmacokinetics ; Area Under Curve ; Drug Interactions ; Female ; Half-Life ; Humans ; Male ; Methotrexate/administration & dosage ; Methotrexate/pharmacokinetics ; Middle Aged ; Niacinamide/administration & dosage ; Niacinamide/pharmacokinetics ; Niacinamide/therapeutic use
Czasopismo naukowe
Tytuł :
Efficacy and safety of peficitinib in rheumatoid arthritis.
Autorzy :
Kaneko Y; Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
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Źródło :
Modern rheumatology [Mod Rheumatol] 2020 Sep; Vol. 30 (5), pp. 773-778. Date of Electronic Publication: 2020 Aug 03.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Clinical Trials, Phase II as Topic*
Adamantane/*analogs & derivatives
Antirheumatic Agents/*therapeutic use
Arthritis, Rheumatoid/*drug therapy
Niacinamide/*analogs & derivatives
Protein Kinase Inhibitors/*therapeutic use
Adamantane/administration & dosage ; Adamantane/adverse effects ; Adamantane/therapeutic use ; Antirheumatic Agents/administration & dosage ; Antirheumatic Agents/adverse effects ; Herpes Zoster/epidemiology ; Herpes Zoster/etiology ; Humans ; Janus Kinases/antagonists & inhibitors ; Niacinamide/administration & dosage ; Niacinamide/adverse effects ; Niacinamide/therapeutic use ; Protein Kinase Inhibitors/administration & dosage ; Protein Kinase Inhibitors/adverse effects
Czasopismo naukowe
Tytuł :
Global PROTAC Toolbox for Degrading BCR-ABL Overcomes Drug-Resistant Mutants and Adverse Effects.
Autorzy :
Yang Y; MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing 100084, China.; Tsinghua University-Peking University Joint Center for Life Sciences, Beijing 100084, China.
Gao H; MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing 100084, China.; Tsinghua University-Peking University Joint Center for Life Sciences, Beijing 100084, China.
Sun X; MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing 100084, China.; Tsinghua University-Peking University Joint Center for Life Sciences, Beijing 100084, China.
Sun Y; MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing 100084, China.; Tsinghua University-Peking University Joint Center for Life Sciences, Beijing 100084, China.
Qiu Y; Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Weng Q; Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.; Center for Drug Safety Evaluation and Research, Zhejiang University, Hangzhou 310058, China.
Rao Y; MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing 100084, China.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Aug 13; Vol. 63 (15), pp. 8567-8583. Date of Electronic Publication: 2020 Jul 23.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Dasatinib/*pharmacology
Fusion Proteins, bcr-abl/*metabolism
Imidazoles/*pharmacology
Niacinamide/*analogs & derivatives
Proteolysis/*drug effects
Pyrazoles/*pharmacology
Pyridazines/*pharmacology
Antineoplastic Agents/chemistry ; Dasatinib/analogs & derivatives ; Drug Design ; Fusion Proteins, bcr-abl/antagonists & inhibitors ; Fusion Proteins, bcr-abl/genetics ; Humans ; Imidazoles/chemistry ; Models, Molecular ; Niacinamide/chemistry ; Niacinamide/pharmacology ; Pyrazoles/chemistry ; Pyridazines/chemistry
Czasopismo naukowe
Tytuł :
Systemic Treatment With Nicotinamide Riboside Is Protective in a Mouse Model of Light-Induced Retinal Degeneration.
Autorzy :
Zhang X; Department of Ophthalmology, School of Medicine, Emory University, Atlanta, Georgia, United States.; Department of Ophthalmology, Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Henneman NF; Department of Ophthalmology, School of Medicine, Emory University, Atlanta, Georgia, United States.; Institut Necker-Enfants Malades (INEM), INSERM U1151/CNRS UMR 8253, 75015 Paris, France.; Center for Visual & Neurocognitive Rehabilitation, Atlanta VAHS, Decatur, Georgia, United States.
Girardot PE; Department of Ophthalmology, School of Medicine, Emory University, Atlanta, Georgia, United States.
Sellers JT; Department of Ophthalmology, School of Medicine, Emory University, Atlanta, Georgia, United States.
Chrenek MA; Department of Ophthalmology, School of Medicine, Emory University, Atlanta, Georgia, United States.
Li Y; Department of Ophthalmology, School of Medicine, Emory University, Atlanta, Georgia, United States.
Wang J; Department of Ophthalmology, School of Medicine, Emory University, Atlanta, Georgia, United States.
Brenner C; Department of Diabetes & Cancer Metabolism, City of Hope National Medical Center, Duarte, California, United States.
Nickerson JM; Department of Ophthalmology, School of Medicine, Emory University, Atlanta, Georgia, United States.
Boatright JH; Department of Ophthalmology, School of Medicine, Emory University, Atlanta, Georgia, United States.; Center for Visual & Neurocognitive Rehabilitation, Atlanta VAHS, Decatur, Georgia, United States.
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Źródło :
Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2020 Aug 03; Vol. 61 (10), pp. 47.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Niacinamide/*analogs & derivatives
Retinal Degeneration/*prevention & control
Animals ; Disease Models, Animal ; Electroretinography ; Fluorescent Antibody Technique ; Injections, Intraperitoneal ; Light/adverse effects ; Male ; Mice ; Mice, Inbred BALB C ; NAD/metabolism ; Niacinamide/administration & dosage ; Niacinamide/therapeutic use ; Photoreceptor Cells, Vertebrate/drug effects ; Photoreceptor Cells, Vertebrate/metabolism ; Photoreceptor Cells, Vertebrate/radiation effects ; Retina/diagnostic imaging ; Retina/drug effects ; Retina/metabolism ; Retina/radiation effects ; Retinal Degeneration/diagnostic imaging ; Retinal Degeneration/etiology ; Tomography, Optical Coherence
Czasopismo naukowe
Tytuł :
Mannose receptor 1 expression does not determine the uptake of high-density mannose dendrimers by activated macrophages populations.
Autorzy :
Kovacs L; Centro de Investigação Translacional em Oncologia, Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina, Universidade de São Paulo, São Paulo, São Paulo, Brazil.
Cabral P; Departamento de Radiofarmacia, Centro de Investigaciones Nucleares, Facultad de Ciencias Universidad de la República, Montevideo, Uruguay.
Chammas R; Centro de Investigação Translacional em Oncologia, Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina, Universidade de São Paulo, São Paulo, São Paulo, Brazil.; Departamento de Radiologia e Oncologia da Faculdade de Medicina da Universidade de São Paulo, São Paulo, São Paulo, Brazil.
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Źródło :
PloS one [PLoS One] 2020 Oct 13; Vol. 15 (10), pp. e0240455. Date of Electronic Publication: 2020 Oct 13 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Benzothiazoles/*chemistry
Carbocyanines/*chemistry
Dendrimers/*chemistry
Macrophages/*metabolism
Mannose/*chemistry
Niacinamide/*analogs & derivatives
Organotechnetium Compounds/*chemistry
Radiopharmaceuticals/*metabolism
Animals ; Interleukin-4/pharmacology ; Lipopolysaccharides/pharmacology ; Macrophages/cytology ; Macrophages/drug effects ; Male ; Membrane Glycoproteins/genetics ; Membrane Glycoproteins/metabolism ; Mice ; Mice, Inbred C57BL ; Niacinamide/chemistry ; Receptors, Immunologic/genetics ; Receptors, Immunologic/metabolism
Czasopismo naukowe
Tytuł :
Autophagy-Inducing Inhalable Co-crystal Formulation of Niclosamide-Nicotinamide for Lung Cancer Therapy.
Autorzy :
Ray E; Institute of Nano Science and Technology (INST), Habitat Centre, Phase- 10, Sector- 64, Mohali, Punjab, 160062, India.
Vaghasiya K; Institute of Nano Science and Technology (INST), Habitat Centre, Phase- 10, Sector- 64, Mohali, Punjab, 160062, India.
Sharma A; Institute of Nano Science and Technology (INST), Habitat Centre, Phase- 10, Sector- 64, Mohali, Punjab, 160062, India.
Shukla R; National Institute of Pharmaceutical Education and Research (Rae Bareli), Lucknow, India.
Khan R; Institute of Nano Science and Technology (INST), Habitat Centre, Phase- 10, Sector- 64, Mohali, Punjab, 160062, India.
Kumar A; University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
Verma RK; Institute of Nano Science and Technology (INST), Habitat Centre, Phase- 10, Sector- 64, Mohali, Punjab, 160062, India. .
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Źródło :
AAPS PharmSciTech [AAPS PharmSciTech] 2020 Sep 17; Vol. 21 (7), pp. 260. Date of Electronic Publication: 2020 Sep 17.
Typ publikacji :
Journal Article
MeSH Terms :
Autophagy/*drug effects
Lung Neoplasms/*drug therapy
Niacinamide/*pharmacology
Niclosamide/*pharmacology
Administration, Inhalation ; Calorimetry, Differential Scanning ; Crystallization ; Desiccation ; Drug Compounding ; Niacinamide/administration & dosage ; Niclosamide/administration & dosage ; Particle Size ; Solubility ; Spectrum Analysis, Raman
Czasopismo naukowe
Tytuł :
Long-term atorvastatin or the combination of atorvastatin and nicotinamide ameliorate insulin resistance and left ventricular diastolic dysfunction in a murine model of obesity.
Autorzy :
Yang X; Department of Cardiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xiong T; Department of Cardiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Ning D; Department of Cardiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Wang T; Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu, China.
Zhong H; Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu, China.
Tang S; Department of Cardiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Mao Y; Department of Cardiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhu G; Yangzhou University College of Veterinary Medicine, Yangzhou, China. Electronic address: .
Wang D; Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu, China. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2020 Sep 01; Vol. 402, pp. 115132. Date of Electronic Publication: 2020 Jul 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Insulin Resistance*
Atorvastatin/*therapeutic use
Niacinamide/*therapeutic use
Obesity/*chemically induced
Ventricular Dysfunction, Left/*drug therapy
Animals ; Anticholesteremic Agents/administration & dosage ; Anticholesteremic Agents/therapeutic use ; Atorvastatin/administration & dosage ; Blood Glucose/drug effects ; Diet, High-Fat/adverse effects ; Drug Therapy, Combination ; Insulin/blood ; Male ; Mice ; Mice, Inbred C57BL ; Niacinamide/administration & dosage ; Random Allocation ; Vitamin B Complex/administration & dosage ; Vitamin B Complex/therapeutic use
Czasopismo naukowe
Tytuł :
In vitro pharmacological effects of peficitinib on lymphocyte activation: a potential treatment for systemic sclerosis with JAK inhibitors.
Autorzy :
Kitanaga Y; Drug Discovery Research, Astellas Pharma, Inc., Tsukuba, Ibaraki.; First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Imamura E; Drug Discovery Research, Astellas Pharma, Inc., Tsukuba, Ibaraki.
Nakahara Y; Drug Discovery Research, Astellas Pharma, Inc., Tsukuba, Ibaraki.
Fukahori H; Drug Discovery Research, Astellas Pharma, Inc., Tsukuba, Ibaraki.
Fujii Y; Drug Discovery Research, Astellas Pharma, Inc., Tsukuba, Ibaraki.
Kubo S; First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Nakayamada S; First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Tanaka Y; First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
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Źródło :
Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2020 Aug 01; Vol. 59 (8), pp. 1957-1968.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adamantane/*analogs & derivatives
Arthritis, Rheumatoid/*metabolism
Janus Kinase Inhibitors/*pharmacology
Lymphocyte Activation/*drug effects
Lymphocytes/*drug effects
Niacinamide/*analogs & derivatives
Scleroderma, Systemic/*metabolism
Adamantane/pharmacology ; Female ; Humans ; Lymphocytes/metabolism ; Male ; Niacinamide/pharmacology ; Phosphorylation/drug effects ; STAT Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans.
Autorzy :
Remie CME; Department of Nutrition and Movement Sciences, School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, Netherlands.
Roumans KHM; Department of Nutrition and Movement Sciences, School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, Netherlands.
Moonen MPB; Department of Nutrition and Movement Sciences, School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, Netherlands.
Connell NJ; Department of Nutrition and Movement Sciences, School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, Netherlands.
Havekes B; Department of Nutrition and Movement Sciences, School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, Netherlands.; Division of Endocrinology, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, Netherlands.
Mevenkamp J; Department of Nutrition and Movement Sciences, School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, Netherlands.; Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, Netherlands.
Lindeboom L; Department of Nutrition and Movement Sciences, School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, Netherlands.; Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, Netherlands.
de Wit VHW; Department of Nutrition and Movement Sciences, School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, Netherlands.
van de Weijer T; Department of Nutrition and Movement Sciences, School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, Netherlands.; Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, Netherlands.
Aarts SABM; Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.
Lutgens E; Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.; Institute for Cardiovascular Prevention (IPEK), Ludwig Maximilian University, Munich, Germany.
Schomakers BV; Laboratory Genetic Metabolic Diseases, Amsterdam Gastroenterology and Metabolism, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.; Core Facility Metabolomics, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.
Elfrink HL; Laboratory Genetic Metabolic Diseases, Amsterdam Gastroenterology and Metabolism, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.; Core Facility Metabolomics, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.
Zapata-Pérez R; Laboratory Genetic Metabolic Diseases, Amsterdam Gastroenterology and Metabolism, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.
Houtkooper RH; Laboratory Genetic Metabolic Diseases, Amsterdam Gastroenterology and Metabolism, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.
Auwerx J; Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Hoeks J; Department of Nutrition and Movement Sciences, School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, Netherlands.
Schrauwen-Hinderling VB; Department of Nutrition and Movement Sciences, School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, Netherlands.; Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, Netherlands.
Phielix E; Department of Nutrition and Movement Sciences, School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, Netherlands.
Schrauwen P; Department of Nutrition and Movement Sciences, School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, Netherlands.
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Źródło :
The American journal of clinical nutrition [Am J Clin Nutr] 2020 Aug 01; Vol. 112 (2), pp. 413-426.
Typ publikacji :
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Acetylcarnitine/*metabolism
Body Composition/*drug effects
Muscle, Skeletal/*metabolism
Niacinamide/*analogs & derivatives
Obesity/*drug therapy
Overweight/*drug therapy
Aged ; Dietary Supplements/analysis ; Female ; Humans ; Male ; Middle Aged ; Muscle, Skeletal/drug effects ; NAD/biosynthesis ; Niacinamide/administration & dosage ; Obesity/metabolism ; Obesity/physiopathology ; Overweight/metabolism ; Overweight/physiopathology
Czasopismo naukowe
Tytuł :
Supplemental Nicotinamide Dose-Dependently Regulates Body Phosphorus Excretion via Altering Type II Sodium-Phosphate Co-Transporter Expressions in Laying Hens.
Autorzy :
Ren ZZ; College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Yan JK; College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Pan C; College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Liu YL; College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Wen HY; College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Yang X; College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Huang XH; Nano Vitamin Engineering Research Center of Shaanxi Province, Xi'an, China.
Lei XG; Department of Animal Science, Cornell University, Ithaca, NY, USA.
Yang XJ; College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
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Źródło :
The Journal of nutrition [J Nutr] 2020 Aug 01; Vol. 150 (8), pp. 2070-2076.
Typ publikacji :
Journal Article; Randomized Controlled Trial, Veterinary; Research Support, Non-U.S. Gov't
MeSH Terms :
Chickens*
Gene Expression Regulation/*drug effects
Niacinamide/*pharmacology
Phosphorus/*metabolism
Sodium-Phosphate Cotransporter Proteins, Type II/*metabolism
Animal Feed/analysis ; Animal Nutritional Physiological Phenomena ; Animals ; Diet/veterinary ; Dietary Supplements ; Dose-Response Relationship, Drug ; Female ; Fibroblast Growth Factors/genetics ; Fibroblast Growth Factors/metabolism ; Glucuronidase/genetics ; Glucuronidase/metabolism ; Intestines/drug effects ; Intestines/physiology ; Kidney/drug effects ; Kidney/metabolism ; Niacinamide/administration & dosage ; Oviposition ; Receptors, Fibroblast Growth Factor/genetics ; Receptors, Fibroblast Growth Factor/metabolism ; Sodium-Phosphate Cotransporter Proteins, Type II/genetics
Czasopismo naukowe
Tytuł :
Peficitinib hydrobromide to treat rheumatoid arthritis.
Autorzy :
Gutiérrez-Ureña SR; Staff, Rheumatology Department, Hospital Civil de Guadalajara FAA, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico. .
Amaya-Cabrera EL; Fellow, Rheumatology Department, Hospital Civil de Guadalajara FAA, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
Uribe-Martínez JF; Fellow, Rheumatology Department, Hospital Civil de Guadalajara FAA, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
Ventura-Valenzuela ME; Fellow, Rheumatology Department, Hospital Civil de Guadalajara FAA, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
Rosal-Arteaga C; Fellow, Rheumatology Department, Hospital Civil de Guadalajara FAA, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
Martínez-Bonilla GE; Staff, Rheumatology Department, Hospital Civil de Guadalajara FAA, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
González-Díaz V; Staff, Rheumatology Department, Hospital Civil de Guadalajara FAA, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
Almengor-Montenegro O; Fellow, Rheumatology Department, Hospital Civil de Guadalajara FAA, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
Cerpa-Cruz S; Chief, Rheumatology Department, Hospital Civil de Guadalajara FAA, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
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Źródło :
Drugs of today (Barcelona, Spain : 1998) [Drugs Today (Barc)] 2020 Aug; Vol. 56 (8), pp. 505-514.
Typ publikacji :
Journal Article
MeSH Terms :
Adamantane/*analogs & derivatives
Arthritis, Rheumatoid/*drug therapy
Niacinamide/*analogs & derivatives
Adamantane/therapeutic use ; Clinical Trials as Topic ; Humans ; Janus Kinases/antagonists & inhibitors ; Niacinamide/therapeutic use ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Reversal of endothelial dysfunction by nicotinamide mononucleotide via extracellular conversion to nicotinamide riboside.
Autorzy :
Mateuszuk Ł; Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Krakow, Poland.
Campagna R; Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Krakow, Poland; Department of Clinical Sciences, Polytechnic University of Marche, Ancona, Italy.
Kutryb-Zając B; Department and Chair of Biochemistry, Medical University of Gdańsk, Gdańsk, Poland.
Kuś K; Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Krakow, Poland.
Słominska EM; Department and Chair of Biochemistry, Medical University of Gdańsk, Gdańsk, Poland.
Smolenski RT; Department and Chair of Biochemistry, Medical University of Gdańsk, Gdańsk, Poland.
Chlopicki S; Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Krakow, Poland; Chair of Pharmacology, Jagiellonian University Medical College, Krakow, Poland. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Aug; Vol. 178, pp. 114019. Date of Electronic Publication: 2020 May 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endothelial Cells/*drug effects
Endothelial Cells/*metabolism
Extracellular Fluid/*drug effects
Extracellular Fluid/*metabolism
Niacinamide/*analogs & derivatives
Nicotinamide Mononucleotide/*metabolism
5'-Nucleotidase/metabolism ; Animals ; Cell Line ; Female ; Humans ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Niacinamide/metabolism ; Nicotinamide Mononucleotide/pharmacology
Czasopismo naukowe
Tytuł :
Differential contribution of metabotropic glutamate receptor 5 common allosteric binding site residues to biased allosteric agonism.
Autorzy :
Sengmany K; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, VIC, Australia.
Hellyer SD; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, VIC, Australia.
Christopoulos A; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, VIC, Australia.
Lapinsky DJ; Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA, United States.
Leach K; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, VIC, Australia.
Gregory KJ; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, VIC, Australia.
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Jul; Vol. 177, pp. 114011. Date of Electronic Publication: 2020 May 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Methoxyhydroxyphenylglycol/*analogs & derivatives
Niacinamide/*analogs & derivatives
Oxazoles/*pharmacology
Piperazines/*pharmacology
Pyridines/*pharmacology
Receptor, Metabotropic Glutamate 5/*agonists
Receptor, Metabotropic Glutamate 5/*metabolism
Allosteric Regulation/drug effects ; Allosteric Site ; Animals ; Binding Sites ; Calcium/metabolism ; Dose-Response Relationship, Drug ; HEK293 Cells ; Humans ; Inositol Phosphates/metabolism ; Methoxyhydroxyphenylglycol/pharmacology ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/metabolism ; Mutation ; Niacinamide/chemistry ; Niacinamide/pharmacology ; Oxazoles/chemistry ; Phosphorylation/drug effects ; Pyridines/chemistry ; Rats ; Receptor, Metabotropic Glutamate 5/genetics
Czasopismo naukowe
Tytuł :
Peficitinib for the treatment of rheumatoid arthritis: an overview from clinical trials.
Autorzy :
Tanaka Y; The First Department of Internal Medicine, University of Occupational and Environmental Health , Japan, Kitakyushu, Japan.
Izutsu H; Astellas Pharma Inc ., Tokyo, Japan.
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Źródło :
Expert opinion on pharmacotherapy [Expert Opin Pharmacother] 2020 Jun; Vol. 21 (9), pp. 1015-1025. Date of Electronic Publication: 2020 Apr 29.
Typ publikacji :
Journal Article
MeSH Terms :
Adamantane/*analogs & derivatives
Antirheumatic Agents/*therapeutic use
Arthritis, Rheumatoid/*drug therapy
Immunosuppressive Agents/*therapeutic use
Niacinamide/*analogs & derivatives
Adamantane/pharmacology ; Adamantane/therapeutic use ; Antirheumatic Agents/pharmacology ; Humans ; Niacinamide/pharmacology ; Niacinamide/therapeutic use
Czasopismo naukowe

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