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Wyszukujesz frazę ""Nicotinic Antagonists"" wg kryterium: Temat


Tytuł :
3-Quinuclidinyl-α-methoxydiphenylacetate: A multi-targeted ligand with antimuscarinic and antinicotinic effects designed for the treatment of anticholinesterase poisoning.
Autorzy :
Timperley CM; Chemical, Biological and Radiological (CBR) Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire SP4 0JQ, UK. Electronic address: .
Bird M; Chemical, Biological and Radiological (CBR) Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire SP4 0JQ, UK.
Gore SJ; Chemical, Biological and Radiological (CBR) Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire SP4 0JQ, UK.
Lindsay CD; Chemical, Biological and Radiological (CBR) Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire SP4 0JQ, UK.
Rice H; Chemical, Biological and Radiological (CBR) Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire SP4 0JQ, UK.
Tattersall JEH; Chemical, Biological and Radiological (CBR) Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire SP4 0JQ, UK.
Whitmore CL; Chemical, Biological and Radiological (CBR) Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire SP4 0JQ, UK.
Green AC; Chemical, Biological and Radiological (CBR) Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire SP4 0JQ, UK.
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Jun 01; Vol. 325, pp. 67-76. Date of Electronic Publication: 2020 Feb 01.
Typ publikacji :
Journal Article
MeSH Terms :
Antidotes/*pharmacology
Antidotes/*therapeutic use
Cholinesterase Inhibitors/*poisoning
Muscarinic Antagonists/*pharmacology
Muscarinic Antagonists/*therapeutic use
Nerve Agents/*poisoning
Nicotinic Antagonists/*pharmacology
Nicotinic Antagonists/*therapeutic use
Animals ; Anticonvulsants/chemistry ; Anticonvulsants/therapeutic use ; Antidotes/chemical synthesis ; CHO Cells ; Cell Line ; Cricetinae ; Cricetulus ; Diaphragm/drug effects ; Guinea Pigs ; Humans ; In Vitro Techniques ; Male ; Muscarinic Antagonists/chemical synthesis ; Muscle, Skeletal/drug effects ; Neurons/drug effects ; Nicotinic Antagonists/chemical synthesis ; Seizures/chemically induced ; Seizures/prevention & control ; Soman/poisoning
Czasopismo naukowe
Tytuł :
Behavioural and pharmacological profiles of zebrafish administrated pyrrolidinyl benzodioxanes and prolinol aryl ethers with high affinity for heteromeric nicotinic acetylcholine receptors.
Autorzy :
Braida D; Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milan, Italy.
Ponzoni L; CNR, Institute of Neuroscience, Via Vanvitelli 32, Milan, Italy.
Moretti M; Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milan, Italy.; CNR, Institute of Neuroscience, Via Vanvitelli 32, Milan, Italy.
Viani P; Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milan, Italy.
Pallavicini M; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Milan, Italy.
Bolchi C; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Milan, Italy.
Appiani R; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Milan, Italy.
Bavo F; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Milan, Italy.
Gotti C; Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milan, Italy. .; CNR, Institute of Neuroscience, Via Vanvitelli 32, Milan, Italy. .
Sala M; Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milan, Italy.; CNR, Institute of Neuroscience, Via Vanvitelli 32, Milan, Italy.
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Źródło :
Psychopharmacology [Psychopharmacology (Berl)] 2020 Aug; Vol. 237 (8), pp. 2317-2326. Date of Electronic Publication: 2020 May 07.
Typ publikacji :
Journal Article
MeSH Terms :
Maze Learning/*drug effects
Nicotinic Agonists/*metabolism
Nicotinic Antagonists/*metabolism
Pyrrolidines/*metabolism
Receptors, Nicotinic/*metabolism
Animals ; Dose-Response Relationship, Drug ; Ethers/metabolism ; Ethers/pharmacology ; Female ; Male ; Maze Learning/physiology ; Morphinans/metabolism ; Morphinans/pharmacology ; Nicotine/metabolism ; Nicotine/pharmacology ; Nicotinic Agonists/pharmacology ; Nicotinic Antagonists/pharmacology ; Pyrrolidines/pharmacology ; Pyrrolidinones/metabolism ; Pyrrolidinones/pharmacology ; Zebrafish
Czasopismo naukowe
Tytuł :
Discovery and Development of 3-(6-Chloropyridine-3-yloxymethyl)-2-azabicyclo[3.1.0]hexane Hydrochloride (SUVN-911): A Novel, Potent, Selective, and Orally Active Neuronal Nicotinic Acetylcholine α4β2 Receptor Antagonist for the Treatment of Depression.
Autorzy :
Nirogi R; Discovery Research, Suven Life Sciences Ltd., Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India.
Mohammed AR; Discovery Research, Suven Life Sciences Ltd., Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India.
Shinde AK; Discovery Research, Suven Life Sciences Ltd., Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India.
Ravella SR; Discovery Research, Suven Life Sciences Ltd., Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India.
Bogaraju N; Discovery Research, Suven Life Sciences Ltd., Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India.
Subramanian R; Discovery Research, Suven Life Sciences Ltd., Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India.
Mekala VR; Discovery Research, Suven Life Sciences Ltd., Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India.
Palacharla RC; Discovery Research, Suven Life Sciences Ltd., Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India.
Muddana N; Discovery Research, Suven Life Sciences Ltd., Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India.
Thentu JB; Discovery Research, Suven Life Sciences Ltd., Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India.
Bhyrapuneni G; Discovery Research, Suven Life Sciences Ltd., Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India.
Abraham R; Discovery Research, Suven Life Sciences Ltd., Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India.
Jasti V; Discovery Research, Suven Life Sciences Ltd., Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Mar 26; Vol. 63 (6), pp. 2833-2853. Date of Electronic Publication: 2020 Feb 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antidepressive Agents/*pharmacology
Nicotinic Antagonists/*pharmacology
Pyridines/*pharmacology
Receptors, Nicotinic/*metabolism
Administration, Oral ; Animals ; Antidepressive Agents/administration & dosage ; Antidepressive Agents/chemistry ; Bridged Bicyclo Compounds/administration & dosage ; Bridged Bicyclo Compounds/chemistry ; Bridged Bicyclo Compounds/pharmacology ; Depression/drug therapy ; Halogenation ; Humans ; Male ; Nicotinic Antagonists/administration & dosage ; Nicotinic Antagonists/chemistry ; Pyridines/administration & dosage ; Pyridines/chemistry ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Dimerization of α-Conotoxins as a Strategy to Enhance the Inhibition of the Human α7 and α9α10 Nicotinic Acetylcholine Receptors.
Autorzy :
Liang J; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, China.; Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266003, China.
Tae HS; Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong, Wollongong, New South Wales 2522, Australia.
Xu X; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, China.; Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266003, China.
Jiang T; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, China.; Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266003, China.
Adams DJ; Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong, Wollongong, New South Wales 2522, Australia.
Yu R; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, China.; Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266003, China.; Innovation Center for Marine Drug Screening & Evaluation, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266003, China.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Mar 26; Vol. 63 (6), pp. 2974-2985. Date of Electronic Publication: 2020 Mar 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Conotoxins/*metabolism
Nicotinic Antagonists/*pharmacology
Protein Multimerization/*drug effects
Receptors, Nicotinic/*metabolism
Humans ; Models, Molecular ; Nicotinic Antagonists/chemistry ; Protein Subunits/antagonists & inhibitors ; Protein Subunits/metabolism ; alpha7 Nicotinic Acetylcholine Receptor/antagonists & inhibitors ; alpha7 Nicotinic Acetylcholine Receptor/metabolism
Czasopismo naukowe
Tytuł :
Structure and Activity Studies of Disulfide-Deficient Analogues of αO-Conotoxin GeXIVA.
Autorzy :
Xu P; Key Laboratory of Tropical Biological Resources of Ministry of Education, Key Laboratory for Marine Drugs of Haikou, School of Life and Pharmaceutical Sciences , Hainan University , Haikou 570228 , China.
Kaas Q; Institute for Molecular Bioscience , The University of Queensland , Brisbane , Queensland 4072 , Australia.
Wu Y; Key Laboratory of Tropical Biological Resources of Ministry of Education, Key Laboratory for Marine Drugs of Haikou, School of Life and Pharmaceutical Sciences , Hainan University , Haikou 570228 , China.
Zhu X; Key Laboratory of Tropical Biological Resources of Ministry of Education, Key Laboratory for Marine Drugs of Haikou, School of Life and Pharmaceutical Sciences , Hainan University , Haikou 570228 , China.
Li X; Key Laboratory of Tropical Biological Resources of Ministry of Education, Key Laboratory for Marine Drugs of Haikou, School of Life and Pharmaceutical Sciences , Hainan University , Haikou 570228 , China.
Harvey PJ; Institute for Molecular Bioscience , The University of Queensland , Brisbane , Queensland 4072 , Australia.
Zhangsun D; Key Laboratory of Tropical Biological Resources of Ministry of Education, Key Laboratory for Marine Drugs of Haikou, School of Life and Pharmaceutical Sciences , Hainan University , Haikou 570228 , China.
Craik DJ; Institute for Molecular Bioscience , The University of Queensland , Brisbane , Queensland 4072 , Australia.
Luo S; Key Laboratory of Tropical Biological Resources of Ministry of Education, Key Laboratory for Marine Drugs of Haikou, School of Life and Pharmaceutical Sciences , Hainan University , Haikou 570228 , China.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Feb 27; Vol. 63 (4), pp. 1564-1575. Date of Electronic Publication: 2020 Feb 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Conotoxins/*chemistry
Disulfides/*chemistry
Nicotinic Antagonists/*chemistry
Receptors, Nicotinic/*metabolism
Amino Acid Sequence ; Animals ; Binding Sites ; Conotoxins/chemical synthesis ; Conotoxins/metabolism ; Humans ; Mice ; Molecular Docking Simulation ; Nicotinic Antagonists/metabolism ; Protein Binding ; Rats ; Receptors, Nicotinic/chemistry
Czasopismo naukowe
Tytuł :
Sex differences in the reward deficit and somatic signs associated with precipitated nicotine withdrawal in rats.
Autorzy :
Tan S; Department of Psychiatry, University of Florida, Gainesville, FL, USA; Department of Histology and Embryology, Hengyang Medical College, University of South China, Hengyang, Hunan, China.
Xue S; Department of Psychiatry, University of Florida, Gainesville, FL, USA.
Behnood-Rod A; Department of Psychiatry, University of Florida, Gainesville, FL, USA.
Chellian R; Department of Psychiatry, University of Florida, Gainesville, FL, USA.
Wilson R; Department of Psychiatry, University of Florida, Gainesville, FL, USA.
Knight P; Department of Psychiatry, University of Florida, Gainesville, FL, USA.
Panunzio S; Department of Psychiatry, University of Florida, Gainesville, FL, USA.
Lyons H; Department of Psychiatry, University of Florida, Gainesville, FL, USA.
Febo M; Department of Psychiatry, University of Florida, Gainesville, FL, USA; Department of Neuroscience, University of Florida, Gainesville, FL, USA.
Bruijnzeel AW; Department of Psychiatry, University of Florida, Gainesville, FL, USA; Department of Neuroscience, University of Florida, Gainesville, FL, USA. Electronic address: .
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Źródło :
Neuropharmacology [Neuropharmacology] 2019 Dec 01; Vol. 160, pp. 107756. Date of Electronic Publication: 2019 Sep 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Reward*
Mecamylamine/*pharmacology
Nicotine/*adverse effects
Nicotinic Antagonists/*pharmacology
Substance Withdrawal Syndrome/*psychology
Animals ; Anxiety/chemically induced ; Brain/drug effects ; Estrous Cycle/drug effects ; Female ; Male ; Mecamylamine/administration & dosage ; Nicotinic Agonists/adverse effects ; Nicotinic Antagonists/administration & dosage ; Rats ; Rats, Wistar ; Self Stimulation/drug effects ; Sex Characteristics ; Substance Withdrawal Syndrome/drug therapy
Czasopismo naukowe
Tytuł :
Oligoarginine Peptides, a New Family of Nicotinic Acetylcholine Receptor Inhibitors.
Autorzy :
Lebedev DS; Department of Molecular Neuroimmune Signaling, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia (D.S.L., E.V.K., I.A.I., N.S.E., N.D.T., E.N.S., E.Y.T., A.E.S., D.S.K., I.E.K., V.I.T.); Department of Neurobiology, Hellenic Pasteur Institute, Athens, Greece (M.Z., S.J.T.); Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, Russia (I.E.K.); Institute of Chemistry and Molecular Engineering, Agricultural University of Georgia, Kakha Bendukidze University Campus, Tbilisi, Georgia (R.K., N.Z., I.I.); and PhysBio of MePhI, Moscow, Russia (V.I.T.).
Kryukova EV; Department of Molecular Neuroimmune Signaling, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia (D.S.L., E.V.K., I.A.I., N.S.E., N.D.T., E.N.S., E.Y.T., A.E.S., D.S.K., I.E.K., V.I.T.); Department of Neurobiology, Hellenic Pasteur Institute, Athens, Greece (M.Z., S.J.T.); Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, Russia (I.E.K.); Institute of Chemistry and Molecular Engineering, Agricultural University of Georgia, Kakha Bendukidze University Campus, Tbilisi, Georgia (R.K., N.Z., I.I.); and PhysBio of MePhI, Moscow, Russia (V.I.T.).
Ivanov IA; Department of Molecular Neuroimmune Signaling, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia (D.S.L., E.V.K., I.A.I., N.S.E., N.D.T., E.N.S., E.Y.T., A.E.S., D.S.K., I.E.K., V.I.T.); Department of Neurobiology, Hellenic Pasteur Institute, Athens, Greece (M.Z., S.J.T.); Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, Russia (I.E.K.); Institute of Chemistry and Molecular Engineering, Agricultural University of Georgia, Kakha Bendukidze University Campus, Tbilisi, Georgia (R.K., N.Z., I.I.); and PhysBio of MePhI, Moscow, Russia (V.I.T.).
Egorova NS; Department of Molecular Neuroimmune Signaling, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia (D.S.L., E.V.K., I.A.I., N.S.E., N.D.T., E.N.S., E.Y.T., A.E.S., D.S.K., I.E.K., V.I.T.); Department of Neurobiology, Hellenic Pasteur Institute, Athens, Greece (M.Z., S.J.T.); Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, Russia (I.E.K.); Institute of Chemistry and Molecular Engineering, Agricultural University of Georgia, Kakha Bendukidze University Campus, Tbilisi, Georgia (R.K., N.Z., I.I.); and PhysBio of MePhI, Moscow, Russia (V.I.T.).
Timofeev ND; Department of Molecular Neuroimmune Signaling, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia (D.S.L., E.V.K., I.A.I., N.S.E., N.D.T., E.N.S., E.Y.T., A.E.S., D.S.K., I.E.K., V.I.T.); Department of Neurobiology, Hellenic Pasteur Institute, Athens, Greece (M.Z., S.J.T.); Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, Russia (I.E.K.); Institute of Chemistry and Molecular Engineering, Agricultural University of Georgia, Kakha Bendukidze University Campus, Tbilisi, Georgia (R.K., N.Z., I.I.); and PhysBio of MePhI, Moscow, Russia (V.I.T.).
Spirova EN; Department of Molecular Neuroimmune Signaling, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia (D.S.L., E.V.K., I.A.I., N.S.E., N.D.T., E.N.S., E.Y.T., A.E.S., D.S.K., I.E.K., V.I.T.); Department of Neurobiology, Hellenic Pasteur Institute, Athens, Greece (M.Z., S.J.T.); Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, Russia (I.E.K.); Institute of Chemistry and Molecular Engineering, Agricultural University of Georgia, Kakha Bendukidze University Campus, Tbilisi, Georgia (R.K., N.Z., I.I.); and PhysBio of MePhI, Moscow, Russia (V.I.T.).
Tufanova EY; Department of Molecular Neuroimmune Signaling, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia (D.S.L., E.V.K., I.A.I., N.S.E., N.D.T., E.N.S., E.Y.T., A.E.S., D.S.K., I.E.K., V.I.T.); Department of Neurobiology, Hellenic Pasteur Institute, Athens, Greece (M.Z., S.J.T.); Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, Russia (I.E.K.); Institute of Chemistry and Molecular Engineering, Agricultural University of Georgia, Kakha Bendukidze University Campus, Tbilisi, Georgia (R.K., N.Z., I.I.); and PhysBio of MePhI, Moscow, Russia (V.I.T.).
Siniavin AE; Department of Molecular Neuroimmune Signaling, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia (D.S.L., E.V.K., I.A.I., N.S.E., N.D.T., E.N.S., E.Y.T., A.E.S., D.S.K., I.E.K., V.I.T.); Department of Neurobiology, Hellenic Pasteur Institute, Athens, Greece (M.Z., S.J.T.); Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, Russia (I.E.K.); Institute of Chemistry and Molecular Engineering, Agricultural University of Georgia, Kakha Bendukidze University Campus, Tbilisi, Georgia (R.K., N.Z., I.I.); and PhysBio of MePhI, Moscow, Russia (V.I.T.).
Kudryavtsev DS; Department of Molecular Neuroimmune Signaling, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia (D.S.L., E.V.K., I.A.I., N.S.E., N.D.T., E.N.S., E.Y.T., A.E.S., D.S.K., I.E.K., V.I.T.); Department of Neurobiology, Hellenic Pasteur Institute, Athens, Greece (M.Z., S.J.T.); Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, Russia (I.E.K.); Institute of Chemistry and Molecular Engineering, Agricultural University of Georgia, Kakha Bendukidze University Campus, Tbilisi, Georgia (R.K., N.Z., I.I.); and PhysBio of MePhI, Moscow, Russia (V.I.T.).
Kasheverov IE; Department of Molecular Neuroimmune Signaling, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia (D.S.L., E.V.K., I.A.I., N.S.E., N.D.T., E.N.S., E.Y.T., A.E.S., D.S.K., I.E.K., V.I.T.); Department of Neurobiology, Hellenic Pasteur Institute, Athens, Greece (M.Z., S.J.T.); Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, Russia (I.E.K.); Institute of Chemistry and Molecular Engineering, Agricultural University of Georgia, Kakha Bendukidze University Campus, Tbilisi, Georgia (R.K., N.Z., I.I.); and PhysBio of MePhI, Moscow, Russia (V.I.T.).
Zouridakis M; Department of Molecular Neuroimmune Signaling, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia (D.S.L., E.V.K., I.A.I., N.S.E., N.D.T., E.N.S., E.Y.T., A.E.S., D.S.K., I.E.K., V.I.T.); Department of Neurobiology, Hellenic Pasteur Institute, Athens, Greece (M.Z., S.J.T.); Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, Russia (I.E.K.); Institute of Chemistry and Molecular Engineering, Agricultural University of Georgia, Kakha Bendukidze University Campus, Tbilisi, Georgia (R.K., N.Z., I.I.); and PhysBio of MePhI, Moscow, Russia (V.I.T.).
Katsarava R; Department of Molecular Neuroimmune Signaling, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia (D.S.L., E.V.K., I.A.I., N.S.E., N.D.T., E.N.S., E.Y.T., A.E.S., D.S.K., I.E.K., V.I.T.); Department of Neurobiology, Hellenic Pasteur Institute, Athens, Greece (M.Z., S.J.T.); Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, Russia (I.E.K.); Institute of Chemistry and Molecular Engineering, Agricultural University of Georgia, Kakha Bendukidze University Campus, Tbilisi, Georgia (R.K., N.Z., I.I.); and PhysBio of MePhI, Moscow, Russia (V.I.T.).
Zavradashvili N; Department of Molecular Neuroimmune Signaling, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia (D.S.L., E.V.K., I.A.I., N.S.E., N.D.T., E.N.S., E.Y.T., A.E.S., D.S.K., I.E.K., V.I.T.); Department of Neurobiology, Hellenic Pasteur Institute, Athens, Greece (M.Z., S.J.T.); Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, Russia (I.E.K.); Institute of Chemistry and Molecular Engineering, Agricultural University of Georgia, Kakha Bendukidze University Campus, Tbilisi, Georgia (R.K., N.Z., I.I.); and PhysBio of MePhI, Moscow, Russia (V.I.T.).
Iagorshvili I; Department of Molecular Neuroimmune Signaling, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia (D.S.L., E.V.K., I.A.I., N.S.E., N.D.T., E.N.S., E.Y.T., A.E.S., D.S.K., I.E.K., V.I.T.); Department of Neurobiology, Hellenic Pasteur Institute, Athens, Greece (M.Z., S.J.T.); Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, Russia (I.E.K.); Institute of Chemistry and Molecular Engineering, Agricultural University of Georgia, Kakha Bendukidze University Campus, Tbilisi, Georgia (R.K., N.Z., I.I.); and PhysBio of MePhI, Moscow, Russia (V.I.T.).
Tzartos SJ; Department of Molecular Neuroimmune Signaling, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia (D.S.L., E.V.K., I.A.I., N.S.E., N.D.T., E.N.S., E.Y.T., A.E.S., D.S.K., I.E.K., V.I.T.); Department of Neurobiology, Hellenic Pasteur Institute, Athens, Greece (M.Z., S.J.T.); Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, Russia (I.E.K.); Institute of Chemistry and Molecular Engineering, Agricultural University of Georgia, Kakha Bendukidze University Campus, Tbilisi, Georgia (R.K., N.Z., I.I.); and PhysBio of MePhI, Moscow, Russia (V.I.T.).
Tsetlin VI; Department of Molecular Neuroimmune Signaling, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia (D.S.L., E.V.K., I.A.I., N.S.E., N.D.T., E.N.S., E.Y.T., A.E.S., D.S.K., I.E.K., V.I.T.); Department of Neurobiology, Hellenic Pasteur Institute, Athens, Greece (M.Z., S.J.T.); Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, Russia (I.E.K.); Institute of Chemistry and Molecular Engineering, Agricultural University of Georgia, Kakha Bendukidze University Campus, Tbilisi, Georgia (R.K., N.Z., I.I.); and PhysBio of MePhI, Moscow, Russia (V.I.T.) .
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Źródło :
Molecular pharmacology [Mol Pharmacol] 2019 Nov; Vol. 96 (5), pp. 664-673. Date of Electronic Publication: 2019 Sep 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Arginine/*metabolism
Arginine/*pharmacology
Nicotinic Antagonists/*metabolism
Nicotinic Antagonists/*pharmacology
Peptides/*metabolism
Peptides/*pharmacology
Animals ; Arginine/chemistry ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Female ; Humans ; Mice ; Nicotinic Antagonists/chemistry ; Peptides/chemistry ; Receptors, Nicotinic/metabolism ; Xenopus laevis
Czasopismo naukowe
Tytuł :
Scorpion toxins interact with nicotinic acetylcholine receptors.
Autorzy :
Kasheverov IE; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.; Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, Russia.
Oparin PB; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Zhmak MN; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Egorova NS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Ivanov IA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Gigolaev AM; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Nekrasova OV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Serebryakova MV; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Russia.
Kudryavtsev DS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Prokopev NA; Department of Bioorganic Chemistry, Faculty of Biology, Lomonosov Moscow State University, Russia.
Hoang AN; Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City, Vietnam.
Tsetlin VI; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Vassilevski AA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.; Moscow Institute of Physics and Technology (State University), Dolgoprudny, Moscow Oblast, Russia.
Utkin YN; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
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Źródło :
FEBS letters [FEBS Lett] 2019 Oct; Vol. 593 (19), pp. 2779-2789. Date of Electronic Publication: 2019 Jul 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Nicotinic Antagonists/*pharmacology
Receptors, Nicotinic/*metabolism
Scorpion Venoms/*pharmacology
Animals ; Mice ; Nicotinic Antagonists/chemistry ; Nicotinic Antagonists/classification ; Protein Binding ; Receptors, Nicotinic/chemistry ; Scorpion Venoms/chemistry ; Scorpion Venoms/classification ; Xenopus
Czasopismo naukowe
Tytuł :
Molecular modelling studies on ɑ7 nicotinic receptor allosteric modulators yields novel filter-based virtual screening protocol.
Autorzy :
Al Rawashdah S; College of Pharmacy, Al Ain University of Science and Technology, Abu Dhabi, 64141, United Arab Emirates.
Hamrouni A; College of Pharmacy, Al Ain University of Science and Technology, Abu Dhabi, 64141, United Arab Emirates.
Sadek B; Department of Pharmacology & Therapeutics, College of Medicine & Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
Amer R; College of Pharmacy, Al Ain University of Science and Technology, Abu Dhabi, 64141, United Arab Emirates.
Metwaly M; College of Pharmacy, Al Ain University of Science and Technology, Abu Dhabi, 64141, United Arab Emirates.
Atatreh N; College of Pharmacy, Al Ain University of Science and Technology, Abu Dhabi, 64141, United Arab Emirates.
Ghattas MA; College of Pharmacy, Al Ain University of Science and Technology, Abu Dhabi, 64141, United Arab Emirates. Electronic address: .
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Źródło :
Journal of molecular graphics & modelling [J Mol Graph Model] 2019 Nov; Vol. 92, pp. 44-54. Date of Electronic Publication: 2019 Jul 02.
Typ publikacji :
Journal Article
MeSH Terms :
Allosteric Site*/drug effects
Models, Molecular*
Nicotinic Agonists/*chemistry
Nicotinic Antagonists/*chemistry
alpha7 Nicotinic Acetylcholine Receptor/*chemistry
Allosteric Regulation/drug effects ; Binding Sites ; Chemical Phenomena ; Drug Discovery ; Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Molecular Structure ; Nicotinic Agonists/pharmacology ; Nicotinic Antagonists/pharmacology ; Protein Binding ; Quantitative Structure-Activity Relationship ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
L-3,3',5-triiodothyronine and pregnenolone sulfate inhibit Torpedo nicotinic acetylcholine receptors.
Autorzy :
Moffett SX; Center for Computational and Integrative Biology, Rutgers University-Camden, Camden, New Jersey, United States of America.
Klein EA; Center for Computational and Integrative Biology, Rutgers University-Camden, Camden, New Jersey, United States of America.; Department of Biology, Rutgers University-Camden, Camden, New Jersey, United States of America.
Brannigan G; Center for Computational and Integrative Biology, Rutgers University-Camden, Camden, New Jersey, United States of America.; Department of Physics, Rutgers University-Camden, Camden, New Jersey, United States of America.
Martin JV; Center for Computational and Integrative Biology, Rutgers University-Camden, Camden, New Jersey, United States of America.; Department of Biology, Rutgers University-Camden, Camden, New Jersey, United States of America.
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Źródło :
PloS one [PLoS One] 2019 Oct 04; Vol. 14 (10), pp. e0223272. Date of Electronic Publication: 2019 Oct 04 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Nicotinic Antagonists/*pharmacology
Pregnenolone/*pharmacology
Receptors, Nicotinic/*metabolism
Torpedo/*metabolism
Triiodothyronine/*pharmacology
Animals ; Dose-Response Relationship, Drug ; GABA-A Receptor Antagonists/chemistry ; GABA-A Receptor Antagonists/pharmacology ; Inhibitory Concentration 50 ; Kinetics ; Molecular Structure ; Nicotinic Antagonists/chemistry ; Oocytes/metabolism ; Pregnenolone/chemistry ; Receptors, GABA-A/metabolism ; Triiodothyronine/chemistry
Czasopismo naukowe
Tytuł :
Structure-Function Elucidation of a New α-Conotoxin, MilIA, from Conus milneedwardsi .
Autorzy :
Peigneur S; Toxicology and Pharmacology, KU Leuven, Campus Gasthuisberg, O & N2, Herestraat 49, P.O. Box 922, 3000 Leuven, Belgium. .
Devi P; Toxicology and Pharmacology, KU Leuven, Campus Gasthuisberg, O & N2, Herestraat 49, P.O. Box 922, 3000 Leuven, Belgium. .; CSIR-National Institute of Oceanography, Dona Paula, Goa 403 004, India. .
Seldeslachts A; Toxicology and Pharmacology, KU Leuven, Campus Gasthuisberg, O & N2, Herestraat 49, P.O. Box 922, 3000 Leuven, Belgium. .
Ravichandran S; Center of Advanced Study in Marine Biology, Annamalai University, Parangipettai, Tamil Nadu 608 502, India. .
Quinton L; Laboratory of Mass Spectrometry, Department of Chemistry, University of Liège, 4000 Liège, Belgium. .
Tytgat J; Toxicology and Pharmacology, KU Leuven, Campus Gasthuisberg, O & N2, Herestraat 49, P.O. Box 922, 3000 Leuven, Belgium. .
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Źródło :
Marine drugs [Mar Drugs] 2019 Sep 16; Vol. 17 (9). Date of Electronic Publication: 2019 Sep 16.
Typ publikacji :
Journal Article
MeSH Terms :
Conotoxins/*pharmacology
Conus Snail/*chemistry
Neurotoxins/*pharmacology
Nicotinic Antagonists/*pharmacology
Peptides/*pharmacology
Amino Acid Sequence/genetics ; Animals ; Conotoxins/genetics ; Conotoxins/isolation & purification ; Mutation ; Neurotoxins/genetics ; Neurotoxins/isolation & purification ; Nicotinic Antagonists/isolation & purification ; Oocytes ; Patch-Clamp Techniques ; Peptides/genetics ; Peptides/isolation & purification ; Receptors, Nicotinic/metabolism ; Recombinant Proteins/metabolism ; Structure-Activity Relationship ; Xenopus laevis
Czasopismo naukowe
Tytuł :
Alkaloids Purified from Aristotelia chilensis Inhibit the Human α3β4 Nicotinic Acetylcholine Receptor with Higher Potencies Compared with the Human α4β2 and α7 Subtypes.
Autorzy :
Arias HR; Department of Pharmaceutical Science, School of Pharmacy , American University of Health Sciences , Signal Hill , California 90755 , United States.
Ortells MO; Facultad de Medicina , Universidad de Morón , and CONICET, 1708 Morón , Buenos Aires , Argentina.
Feuerbach D; Novartis Institutes for Biomedical Research , 4001 Basel , Switzerland.
Burgos V; Laboratory of Natural Products and Drug Discovery, Department of Basic Sciences , Universidad de La Frontera , 4780000 Temuco , Chile.
Paz C; Laboratory of Natural Products and Drug Discovery, Department of Basic Sciences , Universidad de La Frontera , 4780000 Temuco , Chile.
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Źródło :
Journal of natural products [J Nat Prod] 2019 Jul 26; Vol. 82 (7), pp. 1953-1960. Date of Electronic Publication: 2019 Jul 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alkaloids/*pharmacology
Elaeocarpaceae/*chemistry
Nicotinic Antagonists/*pharmacology
Receptors, Nicotinic/*drug effects
alpha7 Nicotinic Acetylcholine Receptor/*antagonists & inhibitors
Alkaloids/chemistry ; Alkaloids/isolation & purification ; Humans ; Molecular Docking Simulation ; Nicotinic Antagonists/chemistry ; Nicotinic Antagonists/isolation & purification ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
α-Conotoxin TxIB: A Uniquely Selective Ligand for α6/α3β2β3 Nicotinic Acetylcholine Receptor Attenuates Nicotine-Induced Conditioned Place Preference in Mice.
Autorzy :
You S; Key Laboratory of Tropical Biological Resources of Ministry of Education, Key Laboratory for Marine Drugs of Haikou, School of Life and Pharmaceutical Sciences, Hainan University, Haikou 570228, China.
Li X; Key Laboratory of Tropical Biological Resources of Ministry of Education, Key Laboratory for Marine Drugs of Haikou, School of Life and Pharmaceutical Sciences, Hainan University, Haikou 570228, China.
Xiong J; Key Laboratory of Tropical Biological Resources of Ministry of Education, Key Laboratory for Marine Drugs of Haikou, School of Life and Pharmaceutical Sciences, Hainan University, Haikou 570228, China.
Zhu X; Key Laboratory of Tropical Biological Resources of Ministry of Education, Key Laboratory for Marine Drugs of Haikou, School of Life and Pharmaceutical Sciences, Hainan University, Haikou 570228, China.
Zhangsun D; Key Laboratory of Tropical Biological Resources of Ministry of Education, Key Laboratory for Marine Drugs of Haikou, School of Life and Pharmaceutical Sciences, Hainan University, Haikou 570228, China.
Zhu X; Key Laboratory of Tropical Biological Resources of Ministry of Education, Key Laboratory for Marine Drugs of Haikou, School of Life and Pharmaceutical Sciences, Hainan University, Haikou 570228, China.
Luo S; Key Laboratory of Tropical Biological Resources of Ministry of Education, Key Laboratory for Marine Drugs of Haikou, School of Life and Pharmaceutical Sciences, Hainan University, Haikou 570228, China. .
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Źródło :
Marine drugs [Mar Drugs] 2019 Aug 22; Vol. 17 (9). Date of Electronic Publication: 2019 Aug 22.
Typ publikacji :
Journal Article
MeSH Terms :
Conditioning, Psychological/*drug effects
Conotoxins/*pharmacology
Nicotinic Antagonists/*pharmacology
Receptors, Nicotinic/*metabolism
Tobacco Use Disorder/*drug therapy
Animals ; Behavior Observation Techniques ; Behavior, Animal/drug effects ; Conotoxins/therapeutic use ; Disease Models, Animal ; Dopamine/analysis ; Dopamine/metabolism ; Humans ; Injections, Subcutaneous ; Ligands ; Male ; Mice ; Nicotine/administration & dosage ; Nicotine/adverse effects ; Nicotinic Antagonists/therapeutic use ; Norepinephrine/analysis ; Norepinephrine/metabolism ; Reward ; Ventral Tegmental Area/chemistry ; Ventral Tegmental Area/drug effects ; Ventral Tegmental Area/metabolism ; gamma-Aminobutyric Acid/analysis ; gamma-Aminobutyric Acid/metabolism
Czasopismo naukowe
Tytuł :
Pinnatoxins' Deleterious Effects on Cholinergic Networks: From Experimental Models to Human Health.
Autorzy :
Delcourt N; Poison Control Centre, Toulouse-Purpan University Hospital and Toulouse NeuroImaging Centre (ToNIC), INSERM1214, Toulouse-Purpan University Hospital, 31059 Toulouse, France.
Lagrange E; Department of Neurology, Reference Center of Neuromuscular Disease, Grenoble University Hospital, 38000 Grenoble, France.
Abadie E; Laboratoire Environnement Ressources du Languedoc-Roussillon, Centre for Marine Biodiversity, Exploitation and Conservation (MARBEC), IRD, Institut Français de Recherche pour l'Exploitation de la Mer (Ifremer), CNRS, Université de Montpellier, CS30171, 34200 Sete Cedex 03, France.
Fessard V; Toxicology of Contaminants Unit, ANSES-French Agency for Food, Environmental and Occupational Health & Safety, 35306 Fougères, France.
Frémy JM; Retired from ANSES-French Agency for Food, Environmental and Occupational Health & Safety, 94701 Maisons-Alfort, France.
Vernoux JP; Research Unit EA 4651 Aliments Bioprocédés Toxicologie Environnements (ABTE), Normandie University, 14000 Caen, France.
Peyrat MB; Risk Assessment Department, ANSES-French Agency for Food, Environmental and Occupational Health & Safety, 94701 Maisons-Alfort, France.
Maignien T; Risk Assessment Department, ANSES-French Agency for Food, Environmental and Occupational Health & Safety, 94701 Maisons-Alfort, France.
Arnich N; Risk Assessment Department, ANSES-French Agency for Food, Environmental and Occupational Health & Safety, 94701 Maisons-Alfort, France.
Molgó J; Institut des Sciences du Vivant Frédéric Joliot, Service d'Ingénierie Moléculaire des Protéines (SIMOPRO), Commissariat à l'Energie Atomique et aux énergies alternatives (CEA) Saclay, Université Paris-Saclay, F-91191 Gif-sur-Yvette, France. .; Institut des Neurosciences Paris-Saclay, Centre National de la Recherche Scientifique (CNRS), UMR 9197 CNRS/Université Paris-Sud, F-91198 Gif-sur-Yvette, France. .
Mattei C; Mitochondrial and Cardiovascular Pathophysiology (MITOVASC), Cardiovascular Mechanotransduction, UMR CNRS 6015, INSERM U1083, Angers University, 49045 Angers, France. .
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Źródło :
Marine drugs [Mar Drugs] 2019 Jul 20; Vol. 17 (7). Date of Electronic Publication: 2019 Jul 20.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Dinoflagellida/*chemistry
Marine Toxins/*toxicity
Nicotinic Antagonists/*toxicity
Paralysis/*chemically induced
Poisoning/*etiology
Acetylcholine/metabolism ; Alkaloids/chemistry ; Alkaloids/toxicity ; Animals ; Disease Models, Animal ; Humans ; Lethal Dose 50 ; Marine Toxins/chemistry ; Muscles/drug effects ; Muscles/innervation ; Muscles/metabolism ; Nicotinic Antagonists/chemistry ; Receptors, Nicotinic/metabolism ; Spiro Compounds/chemistry ; Spiro Compounds/toxicity ; Synaptic Transmission/drug effects ; Toxicity Tests, Acute
Czasopismo naukowe
Tytuł :
Philanthotoxin Analogues That Selectively Inhibit Ganglionic Nicotinic Acetylcholine Receptors with Exceptional Potency.
Autorzy :
Kachel HS; School of Life Sciences , University of Nottingham , University Park , Nottingham NG7 2RD , U.K.
Franzyk H; Department of Drug Design and Pharmacology , University of Copenhagen , Jagtvej 162 , Copenhagen DK-2100 , Denmark.
Mellor IR; School of Life Sciences , University of Nottingham , University Park , Nottingham NG7 2RD , U.K.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2019 Jul 11; Vol. 62 (13), pp. 6214-6222. Date of Electronic Publication: 2019 Jun 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Nicotinic Antagonists/*pharmacology
Polyamines/*pharmacology
Receptors, Nicotinic/*metabolism
Animals ; Drug Design ; Female ; Nicotinic Antagonists/chemical synthesis ; Oocytes/drug effects ; Polyamines/chemical synthesis ; Xenopus laevis
Czasopismo naukowe
Tytuł :
PeIA-5466: A Novel Peptide Antagonist Containing Non-natural Amino Acids That Selectively Targets α3β2 Nicotinic Acetylcholine Receptors.
Autorzy :
Hone AJ
Fisher F
Christensen S
Gajewiak J
Larkin D
Whiteaker P
McIntosh JM; George E. Whalen Veterans Affairs Medical Center , Salt Lake City , Utah 84148 , United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2019 Jul 11; Vol. 62 (13), pp. 6262-6275. Date of Electronic Publication: 2019 Jun 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Nicotinic Antagonists/*pharmacology
Peptides/*pharmacology
Receptors, Nicotinic/*metabolism
Amino Acid Sequence ; Amino Acid Substitution ; Amino Acids/chemistry ; Animals ; Nicotinic Antagonists/chemical synthesis ; Oocytes/drug effects ; Peptides/chemical synthesis ; Structure-Activity Relationship ; Xenopus laevis
Czasopismo naukowe
Tytuł :
Encapsulation of Neurotoxins, Blockers of Nicotinic Acetylcholine Receptors, in Nanomaterials Based on Sulfated Polysaccharides.
Autorzy :
Nguyen TD; Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City, Vietnam.; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Ho Chi Minh City, Vietnam.
Nguyen TN; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Ho Chi Minh City, Vietnam.; Tra Vinh University, Tra Vinh City, Vietnam.
Nguyen KC; Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City, Vietnam.; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Ho Chi Minh City, Vietnam.
Tran QN; Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City, Vietnam.; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Ho Chi Minh City, Vietnam.
Hoang AN; Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City, Vietnam.; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Ho Chi Minh City, Vietnam.
Egorova NS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997, Moscow, Russia.
Starkov VG; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997, Moscow, Russia.
Tsetlin VI; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997, Moscow, Russia.
Utkin YN; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997, Moscow, Russia. .
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Źródło :
Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2019 Jul; Vol. 487 (1), pp. 251-255. Date of Electronic Publication: 2019 Sep 26.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Carriers/*chemistry
Nanoparticles/*chemistry
Neurotoxins/*chemistry
Nicotinic Antagonists/*chemistry
Polysaccharides/*chemistry
Receptors, Nicotinic/*metabolism
Sulfates/*chemistry
Capsules ; Neurotoxins/toxicity ; Nicotinic Antagonists/toxicity ; Particle Size ; Snake Venoms/chemistry
Czasopismo naukowe
Tytuł :
Novel conorfamides from Conus austini venom modulate both nicotinic acetylcholine receptors and acid-sensing ion channels.
Autorzy :
Jin AH; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.
Cristofori-Armstrong B; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia; School of Biomedical Sciences, The University of Queensland, St Lucia, Queensland 4072, Australia.
Rash LD; School of Biomedical Sciences, The University of Queensland, St Lucia, Queensland 4072, Australia.
Román-González SA; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.
Espinosa RA; Universidad Nacional Autonoma de Mexico, Instituto de Química, Coyoacan, Distrito Federal, Mexico.
Lewis RJ; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.
Alewood PF; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.
Vetter I; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia; School of Pharmacy, The University of Queensland, Wooloongabba, Queensland 4102, Australia. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2019 Jun; Vol. 164, pp. 342-348. Date of Electronic Publication: 2019 Apr 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acid Sensing Ion Channel Blockers/*pharmacology
Acid Sensing Ion Channels/*physiology
Mollusk Venoms/*pharmacology
Neuropeptides/*pharmacology
Nicotinic Antagonists/*pharmacology
Receptors, Nicotinic/*physiology
Acid Sensing Ion Channel Blockers/isolation & purification ; Animals ; Conus Snail ; Dose-Response Relationship, Drug ; Female ; Humans ; Mollusk Venoms/isolation & purification ; Neuropeptides/isolation & purification ; Nicotinic Antagonists/isolation & purification ; Xenopus laevis
Czasopismo naukowe
Tytuł :
Di- and heptavalent nicotinic analogues to interfere with α7 nicotinic acetylcholine receptors.
Autorzy :
Brissonnet Y; Université de Nantes, CEISAM, Chimie Et Interdisciplinarité, Synthèse, Analyse, Modélisation, UMR CNRS 6230, UFR des Sciences et des Techniques, 2, rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3, France.
Araoz R; CNRS, Neuro-PSI, UMR9197, 91191 Gif-Sur-Yvette, France; CEA/DRF/JOLIOT/SIMOPRO/Toxines Récepteur et Canaux Ioniques, F-91191 Gif-Sur-Yvette, France. Electronic address: .
Sousa R; Université de Nantes, CEISAM, Chimie Et Interdisciplinarité, Synthèse, Analyse, Modélisation, UMR CNRS 6230, UFR des Sciences et des Techniques, 2, rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3, France.
Percevault L; Université de Nantes, CEISAM, Chimie Et Interdisciplinarité, Synthèse, Analyse, Modélisation, UMR CNRS 6230, UFR des Sciences et des Techniques, 2, rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3, France.
Brument S; Université de Nantes, CEISAM, Chimie Et Interdisciplinarité, Synthèse, Analyse, Modélisation, UMR CNRS 6230, UFR des Sciences et des Techniques, 2, rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3, France.
Deniaud D; Université de Nantes, CEISAM, Chimie Et Interdisciplinarité, Synthèse, Analyse, Modélisation, UMR CNRS 6230, UFR des Sciences et des Techniques, 2, rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3, France.
Servent D; CEA/DRF/JOLIOT/SIMOPRO/Toxines Récepteur et Canaux Ioniques, F-91191 Gif-Sur-Yvette, France.
Le Questel JY; Université de Nantes, CEISAM, Chimie Et Interdisciplinarité, Synthèse, Analyse, Modélisation, UMR CNRS 6230, UFR des Sciences et des Techniques, 2, rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3, France. Electronic address: .
Lebreton J; Université de Nantes, CEISAM, Chimie Et Interdisciplinarité, Synthèse, Analyse, Modélisation, UMR CNRS 6230, UFR des Sciences et des Techniques, 2, rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3, France.
Gouin SG; Université de Nantes, CEISAM, Chimie Et Interdisciplinarité, Synthèse, Analyse, Modélisation, UMR CNRS 6230, UFR des Sciences et des Techniques, 2, rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3, France. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2019 Mar 01; Vol. 27 (5), pp. 700-707. Date of Electronic Publication: 2019 Jan 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Nicotinic Antagonists/*pharmacology
Polyethylene Glycols/*pharmacology
Pyridines/*pharmacology
alpha7 Nicotinic Acetylcholine Receptor/*antagonists & inhibitors
beta-Cyclodextrins/*pharmacology
Animals ; Female ; Humans ; Ligands ; Lymnaea/chemistry ; Molecular Docking Simulation ; Nicotinic Antagonists/chemical synthesis ; Nicotinic Antagonists/metabolism ; Oocytes/drug effects ; Polyethylene Glycols/chemical synthesis ; Polyethylene Glycols/metabolism ; Protein Binding ; Pyridines/chemical synthesis ; Pyridines/metabolism ; Xenopus laevis ; alpha7 Nicotinic Acetylcholine Receptor/chemistry ; alpha7 Nicotinic Acetylcholine Receptor/metabolism ; beta-Cyclodextrins/chemical synthesis ; beta-Cyclodextrins/metabolism
Czasopismo naukowe
Tytuł :
Structure of the Native Muscle-type Nicotinic Receptor and Inhibition by Snake Venom Toxins.
Autorzy :
Rahman MM; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Teng J; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Worrell BT; Department of Molecular, Cellular & Developmental Biology, University of Colorado, Boulder, CO 80309, USA.
Noviello CM; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Lee M; Department of Molecular, Cellular & Developmental Biology, University of Colorado, Boulder, CO 80309, USA.
Karlin A; Center for Molecular Recognition & Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.
Stowell MHB; Department of Molecular, Cellular & Developmental Biology, University of Colorado, Boulder, CO 80309, USA. Electronic address: .
Hibbs RE; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: .
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Źródło :
Neuron [Neuron] 2020 Jun 17; Vol. 106 (6), pp. 952-962.e5. Date of Electronic Publication: 2020 Apr 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Bungarotoxins/*metabolism
Electric Organ/*metabolism
Receptors, Nicotinic/*metabolism
Receptors, Nicotinic/*ultrastructure
Animals ; Binding Sites ; Bungarotoxins/pharmacology ; Carbachol/pharmacology ; Cryoelectron Microscopy ; Molecular Conformation ; Nicotinic Agonists/pharmacology ; Nicotinic Antagonists/pharmacology ; Patch-Clamp Techniques ; Protein Conformation ; Receptors, Nicotinic/drug effects ; Torpedo
Czasopismo naukowe

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