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Tytuł :
Generation and validation of a PITX2-EGFP reporter line of human induced pluripotent stem cells enables isolation of periocular mesenchymal cells.
Autorzy :
Okubo T; Department of Stem Cells and Applied Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.; Basic Research Development Division, Rohto Pharmaceutical Co., Ltd., Osaka 544-8666, Japan.
Hayashi R; Department of Stem Cells and Applied Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan .; Department of Ophthalmology, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan.
Shibata S; Department of Stem Cells and Applied Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.; Basic Research Development Division, Rohto Pharmaceutical Co., Ltd., Osaka 544-8666, Japan.
Kudo Y; Department of Stem Cells and Applied Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.; Basic Research Development Division, Rohto Pharmaceutical Co., Ltd., Osaka 544-8666, Japan.
Ishikawa Y; Department of Ophthalmology, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan.
Inoue S; Department of Ophthalmology, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan.
Kobayashi Y; Department of Ophthalmology, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan.
Honda A; Department of Ophthalmology, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan.
Honma Y; Department of Stem Cells and Applied Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.; Basic Research Development Division, Rohto Pharmaceutical Co., Ltd., Osaka 544-8666, Japan.
Kawasaki S; Department of Ophthalmology, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan.
Nishida K; Department of Ophthalmology, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan.; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Osaka 565-0871, Japan.
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Mar 13; Vol. 295 (11), pp. 3456-3465. Date of Electronic Publication: 2020 Feb 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Validation Study
MeSH Terms :
Cell Separation*
Genes, Reporter*
Eye/*cytology
Green Fluorescent Proteins/*metabolism
Homeodomain Proteins/*metabolism
Induced Pluripotent Stem Cells/*cytology
Mesenchymal Stem Cells/*metabolism
Transcription Factors/*metabolism
Animals ; Cell Line ; Clone Cells ; Ectoderm/cytology ; Embryo, Mammalian/cytology ; Fluorescence ; Humans ; Mice, Inbred ICR ; Phenotype ; Promoter Regions, Genetic/genetics ; RNA Splicing/genetics ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
Selective Laminin-Directed Differentiation of Human Induced Pluripotent Stem Cells into Distinct Ocular Lineages.
Autorzy :
Shibata S; Department of Stem Cells and Applied Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan; Research and Development Division, ROHTO Pharmaceutical Co., Ltd., Osaka, Osaka 544-8666, Japan.
Hayashi R; Department of Stem Cells and Applied Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan; Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan. Electronic address: .
Okubo T; Department of Stem Cells and Applied Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan; Research and Development Division, ROHTO Pharmaceutical Co., Ltd., Osaka, Osaka 544-8666, Japan.
Kudo Y; Department of Stem Cells and Applied Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan; Research and Development Division, ROHTO Pharmaceutical Co., Ltd., Osaka, Osaka 544-8666, Japan.
Katayama T; Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.
Ishikawa Y; Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.
Toga J; Division of Matrixome Research and Application, Institute for Protein Research, Osaka University, Suita, Osaka 565-0871, Japan.
Yagi E; Division of Matrixome Research and Application, Institute for Protein Research, Osaka University, Suita, Osaka 565-0871, Japan.
Honma Y; Department of Stem Cells and Applied Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan; Research and Development Division, ROHTO Pharmaceutical Co., Ltd., Osaka, Osaka 544-8666, Japan.
Quantock AJ; Structural Biophysics Group, School of Optometry and Vision Sciences, College of Biomedical and Life Sciences, Cardiff University, Cardiff CF24 4HQ, Wales, UK.
Sekiguchi K; Division of Matrixome Research and Application, Institute for Protein Research, Osaka University, Suita, Osaka 565-0871, Japan.
Nishida K; Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2018 Nov 06; Vol. 25 (6), pp. 1668-1679.e5.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Differentiation*
Cell Lineage*
Eye/*cytology
Induced Pluripotent Stem Cells/*cytology
Laminin/*metabolism
Actomyosin/metabolism ; Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Cell Count ; Cell Line ; Epithelium, Corneal/cytology ; Female ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Mice, Inbred C57BL ; Neural Crest/cytology ; Pregnancy ; Protein Isoforms/metabolism ; Transcription Factors/metabolism ; Wnt Proteins/metabolism
Czasopismo naukowe
Tytuł :
PAX6 Isoforms, along with Reprogramming Factors, Differentially Regulate the Induction of Cornea-specific Genes.
Autorzy :
Sasamoto Y; Department of Ophthalmology, Osaka University Medical School, Suita, Osaka 565-0871, Japan.
Hayashi R; Department of Stem Cell and Applied Medicine, Osaka University Medical School, Suita, Osaka 565-0871, Japan.
Park SJ; Laboratory of Functional Analysis in silico, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.
Saito-Adachi M; Laboratory of Functional Analysis in silico, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.; Division of Cancer Genomics, National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan.
Suzuki Y; Department of Computational Biology, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba 277-8568, Japan.
Kawasaki S; Department of Ophthalmology, Osaka University Medical School, Suita, Osaka 565-0871, Japan.
Quantock AJ; Structural Biophysics Group, School of Optometry and Vision Sciences, Cardiff University, Cardiff CF24 4HQ, Wales, United Kingdom.
Nakai K; Laboratory of Functional Analysis in silico, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.
Tsujikawa M; Department of Ophthalmology, Osaka University Medical School, Suita, Osaka 565-0871, Japan.
Nishida K; Department of Ophthalmology, Osaka University Medical School, Suita, Osaka 565-0871, Japan.
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Źródło :
Scientific reports [Sci Rep] 2016 Feb 22; Vol. 6, pp. 20807. Date of Electronic Publication: 2016 Feb 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Eye/*growth & development
Keratin-12/*biosynthesis
Keratin-3/*biosynthesis
Kruppel-Like Transcription Factors/*biosynthesis
Octamer Transcription Factor-3/*biosynthesis
PAX6 Transcription Factor/*genetics
Cell Line ; Epithelial Cells/metabolism ; Epithelium, Corneal/growth & development ; Epithelium, Corneal/metabolism ; Eye/metabolism ; Gene Expression Regulation, Developmental ; Humans ; Keratin-12/genetics ; Keratin-3/genetics ; Kruppel-Like Transcription Factors/genetics ; Octamer Transcription Factor-3/genetics ; PAX6 Transcription Factor/biosynthesis ; Protein Isoforms/biosynthesis ; Protein Isoforms/genetics ; Transduction, Genetic
Czasopismo naukowe
Tytuł :
Defects of the Lamina Cribrosa in High Myopia and Glaucoma.
Autorzy :
Miki A; Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan.
Ikuno Y; Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan.
Asai T; Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan.
Usui S; Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan.
Nishida K; Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan.
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Źródło :
PloS one [PLoS One] 2015 Sep 14; Vol. 10 (9), pp. e0137909. Date of Electronic Publication: 2015 Sep 14 (Print Publication: 2015).
Typ publikacji :
Clinical Trial; Comparative Study; Journal Article
MeSH Terms :
Eye*/pathology
Eye*/physiopathology
Glaucoma*/complications
Glaucoma*/pathology
Glaucoma*/physiopathology
Myopia*/complications
Myopia*/pathology
Myopia*/physiopathology
Tomography, Optical Coherence*
Adult ; Aged ; Female ; Humans ; Intraocular Pressure ; Male ; Middle Aged
Czasopismo naukowe
Tytuł :
Evaluation of LOXL1 polymorphisms in eyes with exfoliation glaucoma in Japanese.
Autorzy :
Fuse N; Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan. />Miyazawa A
Nakazawa T
Mengkegale M
Otomo T
Nishida K
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Źródło :
Molecular vision [Mol Vis] 2008 Jul 21; Vol. 14, pp. 1338-43. Date of Electronic Publication: 2008 Jul 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amino Acid Oxidoreductases/*genetics
Asian Continental Ancestry Group/*genetics
Exfoliation Syndrome/*genetics
Eye/*pathology
Glaucoma/*complications
Glaucoma/*genetics
Polymorphism, Single Nucleotide/*genetics
Aged ; Case-Control Studies ; Exfoliation Syndrome/complications ; Female ; Gene Frequency ; Haplotypes ; Humans ; Japan ; Male ; Phenotype
Czasopismo naukowe
Tytuł :
Ocular pharmacokinetic/pharmacodynamic modeling for timolol in rabbits using a telemetry system.
Autorzy :
Sakanaka K; Santen Pharmaceutical Co., Ltd., Nara Research and Development Center, 8916-16 Takayama-cho, Ikoma 630-0101, Japan. />Kawazu K
Tomonari M
Kitahara T
Nakashima M
Nishida K
Nakamura J
Sasaki H
Higuchi S
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Źródło :
Biological & pharmaceutical bulletin [Biol Pharm Bull] 2008 May; Vol. 31 (5), pp. 970-5.
Typ publikacji :
Journal Article
MeSH Terms :
Adrenergic beta-Antagonists/*pharmacokinetics
Adrenergic beta-Antagonists/*pharmacology
Eye/*metabolism
Timolol/*pharmacokinetics
Timolol/*pharmacology
Adrenergic beta-Antagonists/administration & dosage ; Algorithms ; Animals ; Injections ; Intraocular Pressure/drug effects ; Male ; Rabbits ; Telemetry ; Timolol/administration & dosage
Czasopismo naukowe
Tytuł :
Ocular pharmacokinetic/ pharmacodynamic modeling for bunazosin after instillation into rabbits.
Autorzy :
Sakanaka K; Department of Hospital Pharmacy, Nagasaki University School of Medicine, Nagasaki 852-8501, Japan. />Kawazu K
Tomonari M
Kitahara T
Nakashima M
Kawakami S
Nishida K
Nakamura J
Sasaki H
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Źródło :
Pharmaceutical research [Pharm Res] 2004 May; Vol. 21 (5), pp. 770-6.
Typ publikacji :
Journal Article
MeSH Terms :
Adrenergic alpha-Antagonists/*pharmacokinetics
Eye/*metabolism
Quinazolines/*pharmacokinetics
Adrenergic alpha-Antagonists/administration & dosage ; Adrenergic alpha-Antagonists/pharmacology ; Algorithms ; Animals ; Aqueous Humor/physiology ; Injections ; Intraocular Pressure/drug effects ; Male ; Models, Biological ; Quinazolines/administration & dosage ; Quinazolines/pharmacology ; Rabbits ; Tears/metabolism
Czasopismo naukowe
Tytuł :
Functional bioengineered corneal epithelial sheet grafts from corneal stem cells expanded ex vivo on a temperature-responsive cell culture surface.
Autorzy :
Nishida K; Department of Ophthalmology, Osaka University Medical School, Suita, Japan. />Yamato M
Hayashida Y
Watanabe K
Maeda N
Watanabe H
Yamamoto K
Nagai S
Kikuchi A
Tano Y
Okano T
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Źródło :
Transplantation [Transplantation] 2004 Feb 15; Vol. 77 (3), pp. 379-85.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Temperature*
Cytological Techniques/*instrumentation
Epithelium, Corneal/*transplantation
Eye/*cytology
Stem Cells/*cytology
Tissue Engineering/*methods
3T3 Cells ; Animals ; Cell Division ; Cells, Cultured ; Epithelium, Corneal/cytology ; Eye/pathology ; Humans ; Mice ; Microscopy, Electron ; Ophthalmologic Surgical Procedures ; Polymers ; Preservation, Biological ; Rabbits ; Surface Properties ; Transplantation, Heterologous
Czasopismo naukowe
Tytuł :
Ocular absorption behavior of palmitoyl tilisolol, an amphiphilic prodrug of tilisolol, for ocular drug delivery.
Autorzy :
Kawakami S; School of Pharmaceutical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan. />Nishida K
Mukai T
Yamamura K
Kobayashi K
Sakaeda T
Nakamura J
Nakashima M
Sasaki H
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Źródło :
Journal of pharmaceutical sciences [J Pharm Sci] 2001 Dec; Vol. 90 (12), pp. 2113-20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adrenergic beta-Antagonists/*pharmacokinetics
Drug Delivery Systems/*methods
Eye/*metabolism
Isoquinolines/*pharmacokinetics
Prodrugs/*pharmacokinetics
Surface-Active Agents/*pharmacokinetics
Absorption/drug effects ; Absorption/physiology ; Administration, Topical ; Adrenergic beta-Antagonists/administration & dosage ; Adrenergic beta-Antagonists/blood ; Animals ; Eye/drug effects ; Isoquinolines/administration & dosage ; Isoquinolines/blood ; Male ; Palmitic Acids/administration & dosage ; Palmitic Acids/blood ; Palmitic Acids/pharmacokinetics ; Prodrugs/administration & dosage ; Rabbits ; Surface-Active Agents/administration & dosage ; Tears/drug effects ; Tears/metabolism
Czasopismo naukowe
Tytuł :
Controlled release and ocular absorption of tilisolol utilizing ophthalmic insert-incorporated lipophilic prodrugs.
Autorzy :
Kawakami S; School of Pharmaceutical Sciences, Nagasaki University, 1-14 Bunkyo-machi, 852-8521, Nagasaki, Japan. />Nishida K
Mukai T
Yamamura K
Nakamura J
Sakaeda T
Nakashima M
Sasaki H
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Źródło :
Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2001 Oct 19; Vol. 76 (3), pp. 255-63.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adrenergic beta-Antagonists/*administration & dosage
Adrenergic beta-Antagonists/*pharmacokinetics
Eye/*metabolism
Isoquinolines/*administration & dosage
Isoquinolines/*pharmacokinetics
Prodrugs/*administration & dosage
Absorption ; Animals ; Aqueous Humor/metabolism ; Area Under Curve ; Biocompatible Materials ; Chemical Phenomena ; Chemistry, Physical ; Chromatography, High Pressure Liquid ; Delayed-Action Preparations ; Lipids/chemistry ; Male ; Prodrugs/pharmacokinetics ; Rabbits ; Solubility ; Spectrophotometry, Ultraviolet
Czasopismo naukowe
Tytuł :
Pharmacokinetic prediction of the ocular absorption of an instilled drug with ophthalmic viscous vehicle.
Autorzy :
Sasaki H; Department of Hospital Pharmacy, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. />Yamamura K
Mukai T
Nishida K
Nakamura J
Nakashima M
Ichikawa M
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Źródło :
Biological & pharmaceutical bulletin [Biol Pharm Bull] 2000 Nov; Vol. 23 (11), pp. 1352-6.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ophthalmic Solutions*
Adrenergic beta-Antagonists/*pharmacokinetics
Eye/*metabolism
Isoquinolines/*pharmacokinetics
Absorption ; Adrenergic beta-Antagonists/administration & dosage ; Adrenergic beta-Antagonists/blood ; Algorithms ; Animals ; Aqueous Humor/metabolism ; Area Under Curve ; Carboxymethylcellulose Sodium ; Injections, Intravenous ; Isoquinolines/administration & dosage ; Isoquinolines/blood ; Male ; Models, Biological ; Pharmaceutic Aids ; Pharmaceutical Vehicles ; Rabbits ; Tears/chemistry ; Viscosity
Czasopismo naukowe
Tytuł :
Characterization of ocular pharmacokinetics of beta-blockers using a diffusion model after instillation.
Autorzy :
Yamamura K; School of Pharmaceutical Sciences, Nagasaki University, Nagasaki City, Japan.
Sasaki H
Nakashima M
Ichikawa M
Mukai T
Nishida K
Nakamura J
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Źródło :
Pharmaceutical research [Pharm Res] 1999 Oct; Vol. 16 (10), pp. 1596-601.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adrenergic beta-Antagonists/*pharmacokinetics
Eye/*metabolism
Absorption ; Administration, Topical ; Adrenergic beta-Antagonists/administration & dosage ; Algorithms ; Animals ; Anterior Chamber/metabolism ; Aqueous Humor/metabolism ; Cornea/metabolism ; Dextrans ; Diffusion ; Fluorescein-5-isothiocyanate/analogs & derivatives ; Isoquinolines/administration & dosage ; Isoquinolines/pharmacokinetics ; Models, Biological ; Rabbits ; Timolol/administration & dosage ; Timolol/pharmacokinetics
Czasopismo naukowe
Tytuł :
Drug absorption behavior after periocular injections.
Autorzy :
Sasaki H; Department of Hospital Pharmacy, Nagasaki University School of Medicine, Japan.
Kashiwagi S
Mukai T
Nishida K
Nakamura J
Nakashima M
Ichikawa M
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Źródło :
Biological & pharmaceutical bulletin [Biol Pharm Bull] 1999 Sep; Vol. 22 (9), pp. 956-60.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Eye/*metabolism
Isoquinolines/*pharmacokinetics
Absorption ; Adrenergic beta-Antagonists/administration & dosage ; Adrenergic beta-Antagonists/pharmacokinetics ; Analysis of Variance ; Animals ; Area Under Curve ; Drug Administration Routes ; Isoquinolines/administration & dosage ; Male ; Ophthalmic Solutions ; Rabbits
Czasopismo naukowe
Tytuł :
Topical delivery system of ophthalmic drugs by periocular injection with viscous solution.
Autorzy :
Sasaki H; Department of Hospital Pharmacy, Nagasaki University School of Medicine, Japan.
Kashiwagi S
Mukai T
Nishida K
Nakamura J
Nakashima M
Ichikawa M
Pokaż więcej
Źródło :
Biological & pharmaceutical bulletin [Biol Pharm Bull] 1999 Sep; Vol. 22 (9), pp. 961-5.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Eye/*metabolism
Isoquinolines/*pharmacokinetics
Absorption ; Administration, Topical ; Adrenergic beta-Antagonists/pharmacokinetics ; Animals ; Carboxymethylcellulose Sodium/chemistry ; Chemistry, Pharmaceutical ; Drug Administration Routes ; Drug Delivery Systems ; Isoquinolines/administration & dosage ; Male ; Ophthalmic Solutions/administration & dosage ; Ophthalmic Solutions/pharmacokinetics ; Rabbits
Czasopismo naukowe
Tytuł :
Enhancement of ocular drug penetration.
Autorzy :
Sasaki H; Department of Hospital Pharmacy, Nagasaki University School of Medicine, Japan.
Yamamura K
Mukai T
Nishida K
Nakamura J
Nakashima M
Ichikawa M
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Źródło :
Critical reviews in therapeutic drug carrier systems [Crit Rev Ther Drug Carrier Syst] 1999; Vol. 16 (1), pp. 85-146.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Delivery Systems*
Eye/*metabolism
Ophthalmic Solutions/*pharmacokinetics
Drug Carriers ; Eye/anatomy & histology ; Humans ; Ocular Physiological Phenomena
Czasopismo naukowe
Tytuł :
In-situ ocular absorption of ophthalmic beta-blockers through ocular membranes in albino rabbits.
Autorzy :
Sasaki H; Department of Hospital Pharmacy, Nagasaki University School of Medicine, Japan.
Ichikawa M
Kawakami S
Yamamura K
Mukai T
Nishida K
Nakamura J
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Źródło :
The Journal of pharmacy and pharmacology [J Pharm Pharmacol] 1997 Feb; Vol. 49 (2), pp. 140-4.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adrenergic beta-Antagonists/*pharmacokinetics
Eye/*metabolism
Absorption ; Adrenergic beta-Antagonists/administration & dosage ; Animals ; Carteolol/pharmacokinetics ; Conjunctiva/metabolism ; Cornea/metabolism ; Male ; Propanolamines/pharmacokinetics ; Rabbits ; Sclera/metabolism ; Timolol/pharmacokinetics
Czasopismo naukowe
Tytuł :
In situ ocular absorption of tilisolol through ocular membranes in albino rabbits.
Autorzy :
Sasaki H; Department of Hospital Pharmacy, Nagasaki University School of Medicine, Japan.
Ichikawa M
Kawakami S
Yamamura K
Nishida K
Nakamura J
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Źródło :
Journal of pharmaceutical sciences [J Pharm Sci] 1996 Sep; Vol. 85 (9), pp. 940-3.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adrenergic beta-Antagonists/*pharmacokinetics
Eye/*metabolism
Isoquinolines/*pharmacokinetics
Absorption ; Animals ; Aqueous Humor/metabolism ; Male ; Rabbits ; Vitreous Body/metabolism
Czasopismo naukowe
Tytuł :
Effect of preservatives on systemic delivery of insulin by ocular instillation in rabbits.
Autorzy :
Sasaki H; School of Pharmaceutical Sciences, Nagasaki University, Japan.
Tei C
Yamamura K
Nishida K
Nakamura J
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Źródło :
The Journal of pharmacy and pharmacology [J Pharm Pharmacol] 1994 Nov; Vol. 46 (11), pp. 871-5.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Eye/*metabolism
Insulin/*administration & dosage
Preservatives, Pharmaceutical/*pharmacology
Absorption ; Animals ; Benzalkonium Compounds/administration & dosage ; Benzalkonium Compounds/pharmacology ; Biological Availability ; Blood Glucose/metabolism ; Insulin/pharmacokinetics ; Insulin/pharmacology ; Male ; Ophthalmic Solutions ; Rabbits ; Spectrophotometry, Ultraviolet
Czasopismo naukowe

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