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Wyszukujesz frazę ""Nishimura, T."" wg kryterium: Autor


Tytuł :
Function of Prion Protein and the Family Member, Shadoo.
Autorzy :
Onodera T; Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo, Japan.
Nishimura T; Pharmaceuticals and Medical Devices Agency, Tokyo, Japan.
Sugiura K; Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo, Japan.
Sakudo A; Laboratory of Biometabolic Chemistry, School of Health Sciences, University of the Ryukyus, Nishihara, Japan.
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Źródło :
Current issues in molecular biology [Curr Issues Mol Biol] 2020; Vol. 36, pp. 67-88. Date of Electronic Publication: 2019 Sep 27.
Typ publikacji :
Journal Article
MeSH Terms :
Brain/*metabolism
Nerve Tissue Proteins/*metabolism
PrPC Proteins/*metabolism
Animals ; Apoptosis/genetics ; Brain/pathology ; Gain of Function Mutation ; Loss of Function Mutation ; Mice ; Nerve Tissue Proteins/genetics ; Neurodegenerative Diseases/metabolism ; Neurons/metabolism ; PrPC Proteins/genetics ; PrPC Proteins/physiology ; PrPSc Proteins/metabolism ; Protein Domains ; Signal Transduction/genetics ; Stress, Physiological/genetics
Czasopismo naukowe
Tytuł :
Psychomotor effect differences between l-methamphetamine and d-methamphetamine are independent of murine plasma and brain pharmacokinetics profiles.
Autorzy :
Nishimura T; Department of Scientific Research, Fujimoto Pharmaceutical Corporation, 1-3-40 Nishiotsuka, Matsubara, Osaka, 580-8503, Japan. .
Takahata K; Department of Scientific Research, Fujimoto Pharmaceutical Corporation, 1-3-40 Nishiotsuka, Matsubara, Osaka, 580-8503, Japan.
Kosugi Y; Department of Scientific Research, Fujimoto Pharmaceutical Corporation, 1-3-40 Nishiotsuka, Matsubara, Osaka, 580-8503, Japan.
Tanabe T; Department of Scientific Research, Fujimoto Pharmaceutical Corporation, 1-3-40 Nishiotsuka, Matsubara, Osaka, 580-8503, Japan.
Muraoka S; Department of Scientific Research, Fujimoto Pharmaceutical Corporation, 1-3-40 Nishiotsuka, Matsubara, Osaka, 580-8503, Japan.
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Źródło :
Journal of neural transmission (Vienna, Austria : 1996) [J Neural Transm (Vienna)] 2017 May; Vol. 124 (5), pp. 519-523. Date of Electronic Publication: 2017 Feb 17.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Brain/*drug effects
Central Nervous System Stimulants/*pharmacology
Methamphetamine/*pharmacology
Motor Activity/*drug effects
Animals ; Brain/metabolism ; Central Nervous System Stimulants/blood ; Central Nervous System Stimulants/pharmacokinetics ; Dose-Response Relationship, Drug ; Male ; Methamphetamine/blood ; Methamphetamine/pharmacokinetics ; Mice ; Stereoisomerism ; Stereotyped Behavior/drug effects ; Time Factors
Czasopismo naukowe
Tytuł :
An immunohistochemical, enzymatic, and behavioral study of CD157/BST-1 as a neuroregulator.
Autorzy :
Higashida H; Research Centre for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan. .
Liang M; Research Centre for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.
Yoshihara T; Research Centre for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.
Akther S; Research Centre for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.
Fakhrul A; Research Centre for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.
Stanislav C; Research Centre for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.
Nam TS; Department of Biochemistry, Chonbuk National University Medical School, Jeonju, South Korea.
Kim UH; Department of Biochemistry, Chonbuk National University Medical School, Jeonju, South Korea.
Kasai S; Research Centre for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.
Nishimura T; Research Centre for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.
Al Mahmuda N; Research Centre for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.
Yokoyama S; Research Centre for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.
Ishihara K; Department of Immunology and Molecular Genetics, Kawasaki Medical School, Kurashiki, Okayama, 701-0192, Japan.
Gerasimenko M; Research Centre for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.
Salmina A; Research Centre for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.; Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, Krasnoyarsk State Medical University, Krasnoyarsk, Russia, 660022.
Zhong J; Research Centre for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.
Tsuji T; Research Centre for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.
Tsuji C; Research Centre for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.
Lopatina O; Research Centre for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.; Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, Krasnoyarsk State Medical University, Krasnoyarsk, Russia, 660022.
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Źródło :
BMC neuroscience [BMC Neurosci] 2017 Mar 24; Vol. 18 (1), pp. 35. Date of Electronic Publication: 2017 Mar 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Social Behavior*
ADP-ribosyl Cyclase/*metabolism
Antigens, CD/*metabolism
Brain/*enzymology
ADP-ribosyl Cyclase/genetics ; ADP-ribosyl Cyclase 1/genetics ; ADP-ribosyl Cyclase 1/metabolism ; Animals ; Animals, Newborn ; Antigens, CD/genetics ; Avoidance Learning/physiology ; Brain/embryology ; Brain/growth & development ; Cyclic ADP-Ribose/metabolism ; GPI-Linked Proteins/genetics ; GPI-Linked Proteins/metabolism ; HEK293 Cells ; Humans ; Immunohistochemistry ; Male ; Membrane Glycoproteins/genetics ; Membrane Glycoproteins/metabolism ; Mice, Inbred C57BL ; Mice, Inbred ICR ; Mice, Knockout ; Models, Animal ; NADP/analogs & derivatives ; NADP/metabolism ; Nestin/metabolism ; RNA, Messenger/metabolism
Czasopismo naukowe
Tytuł :
Prognostic factors in patients with brain metastasis from non-small cell lung cancer treated with whole-brain radiotherapy.
Autorzy :
Harada H; Division of Radiation Oncology, Shizuoka Cancer Center, Nagaizumi-cho, Sunto-gun, Shizuoka, Japan.
Asakura H
Ogawa H
Mori K
Takahashi T
Nakasu Y
Nishimura T
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Źródło :
Journal of cancer research and therapeutics [J Cancer Res Ther] 2016 Jan-Mar; Vol. 12 (1), pp. 267-70.
Typ publikacji :
Journal Article
MeSH Terms :
Adenocarcinoma/*radiotherapy
Brain/*radiation effects
Brain Neoplasms/*radiotherapy
Carcinoma, Non-Small-Cell Lung/*radiotherapy
Adenocarcinoma/pathology ; Aged ; Brain/pathology ; Brain Neoplasms/pathology ; Brain Neoplasms/secondary ; Carcinoma, Non-Small-Cell Lung/pathology ; Cranial Irradiation ; Disease-Free Survival ; Female ; Humans ; Karnofsky Performance Status ; Male ; Middle Aged ; Prognosis ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Inter-individual relationships in empathic traits and feedback-related fronto-central brain activity: an event-related potential study.
Autorzy :
Motomura Y
Takeshita A
Egashira Y
Nishimura T
Kim YK
Watanuki S
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Źródło :
Journal of physiological anthropology [J Physiol Anthropol] 2015 Mar 24; Vol. 34, pp. 14. Date of Electronic Publication: 2015 Mar 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain/*physiology
Empathy/*physiology
Evoked Potentials/*physiology
Feedback, Physiological/*physiology
Adult ; Female ; Gambling ; Humans ; Male ; Surveys and Questionnaires ; Task Performance and Analysis ; Young Adult
Czasopismo naukowe
Tytuł :
Magnetoencephalographic study on forward suppression by ipsilateral, contralateral, and binaural maskers.
Autorzy :
Nishimura T; Department of Otolaryngology-Head and Neck surgery, Nara Medical University, Nara, Japan. t />Uratani Y
Okayasu T
Nakagawa S
Hosoi H
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Źródło :
PloS one [PLoS One] 2013 Jun 06; Vol. 8 (6), pp. e66225. Date of Electronic Publication: 2013 Jun 06 (Print Publication: 2013).
Typ publikacji :
Journal Article
MeSH Terms :
Psychoacoustics*
Auditory Perception/*physiology
Brain/*physiology
Perceptual Masking/*physiology
Adult ; Auditory Threshold/physiology ; Dichotic Listening Tests ; Female ; Functional Laterality/physiology ; Humans ; Magnetoencephalography ; Male ; Pitch Discrimination/physiology
Czasopismo naukowe
Tytuł :
Low vitamin and carotenoid levels are related to cerebral white matter lesions.
Autorzy :
Ohshima Y; Department of Neurology and Gerontology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Mizuno T
Yamada K
Matsumoto S
Nagakane Y
Kondo M
Kuriyama N
Miyazaki T
Takeda K
Nishimura T
Nakagawa M
Ozasa K
Watanabe Y
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Źródło :
The journal of nutrition, health & aging [J Nutr Health Aging] 2013; Vol. 17 (5), pp. 456-60.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ascorbic Acid/*blood
Ascorbic Acid Deficiency/*complications
Brain/*pathology
Brain Diseases/*etiology
Carotenoids/*deficiency
Tocopherols/*blood
Vitamin E Deficiency/*complications
Aged ; Antioxidants/metabolism ; Brain Diseases/pathology ; Carotenoids/blood ; Deficiency Diseases/complications ; Female ; Geriatric Assessment ; Humans ; Japan ; Male ; Middle Aged ; Nutrition Assessment ; Nutritional Status ; Sex Factors ; Vitamins/blood
Czasopismo naukowe
Tytuł :
Erlin-2 is associated with active γ-secretase in brain and affects amyloid β-peptide production.
Autorzy :
Teranishi Y; Karolinska Institutet Dainippon Sumitomo Pharma Alzheimer Center, KI-Alzheimer Disease Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Novum, Stockholm SE-141 86, Sweden.
Hur JY
Gu GJ
Kihara T
Ishikawa T
Nishimura T
Winblad B
Behbahani H
Kamali-Moghaddam M
Frykman S
Tjernberg LO
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2012 Aug 03; Vol. 424 (3), pp. 476-81. Date of Electronic Publication: 2012 Jul 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amyloid Precursor Protein Secretases/*metabolism
Amyloid beta-Peptides/*biosynthesis
Brain/*metabolism
Membrane Proteins/*metabolism
Alzheimer Disease/metabolism ; Animals ; Humans ; Membrane Proteins/genetics ; Mice ; RNA, Small Interfering/genetics ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Successful treatment of cerebral hemorrhage using computed tomography angiography in a patient with left-ventricular-assist device.
Autorzy :
Morito H; Department of Cardiothoracic Surgery, The University of Tokyo Hospital, Tokyo, Japan.
Nishimura T
Ando M
Kinoshita O
Hisagi M
Imai H
Iijima A
Motomura N
Kyo S
Ono M
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Źródło :
Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs [J Artif Organs] 2012 Mar; Vol. 15 (1), pp. 90-3. Date of Electronic Publication: 2011 Oct 28.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Heart-Assist Devices*
Brain/*diagnostic imaging
Heart Failure/*surgery
Intracranial Hemorrhages/*diagnostic imaging
Adult ; Brain/surgery ; Humans ; Intracranial Hemorrhages/surgery ; Male ; Radiography
Czasopismo naukowe
Tytuł :
Age-dependent brain temperature decline assessed by diffusion-weighted imaging thermometry.
Autorzy :
Sakai K; Department of Human Health Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan. .
Yamada K
Mori S
Sugimoto N
Nishimura T
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Źródło :
NMR in biomedicine [NMR Biomed] 2011 Nov; Vol. 24 (9), pp. 1063-7. Date of Electronic Publication: 2011 Jan 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aging/*physiology
Body Temperature/*physiology
Brain/*physiology
Diffusion Magnetic Resonance Imaging/*methods
Adult ; Brain/growth & development ; Cerebral Ventricles/physiology ; Female ; Humans ; Male ; Middle Aged ; Organ Size ; Phantoms, Imaging ; Young Adult
Czasopismo naukowe
Tytuł :
Diffusion tensor imaging and tract-based spatial statistics in obsessive-compulsive disorder.
Autorzy :
Nakamae T; Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii-cho 465, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan. />Narumoto J
Sakai Y
Nishida S
Yamada K
Nishimura T
Fukui K
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Źródło :
Journal of psychiatric research [J Psychiatr Res] 2011 May; Vol. 45 (5), pp. 687-90. Date of Electronic Publication: 2010 Oct 20.
Typ publikacji :
Journal Article
MeSH Terms :
Brain/*pathology
Corpus Callosum/*pathology
Diffusion Magnetic Resonance Imaging/*methods
Nerve Fibers, Myelinated/*pathology
Obsessive-Compulsive Disorder/*diagnosis
Analysis of Variance ; Anisotropy ; Brain Mapping ; Humans ; Image Processing, Computer-Assisted
Czasopismo naukowe
Tytuł :
Neural correlates of performance on the different scoring systems of the clock drawing test.
Autorzy :
Matsuoka T; Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan. />Narumoto J
Shibata K
Okamura A
Nakamura K
Nakamae T
Yamada K
Nishimura T
Fukui K
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Źródło :
Neuroscience letters [Neurosci Lett] 2011 Jan 10; Vol. 487 (3), pp. 421-5. Date of Electronic Publication: 2010 Nov 03.
Typ publikacji :
Journal Article
MeSH Terms :
Brain Mapping*
Neuropsychological Tests*
Alzheimer Disease/*physiopathology
Brain/*physiopathology
Aged ; Alzheimer Disease/diagnosis ; Female ; Humans ; Magnetic Resonance Imaging ; Male
Czasopismo naukowe
Tytuł :
Moyamoya patients exhibit higher brain temperatures than normal controls.
Autorzy :
Yamada K; Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii-cho, Kawaramachi Hirokoji Sagaru, Kamigyo-ku, Kyoto City, Kyoto, Japan. />Sakai K
Akazawa K
Yuen S
Sugimoto N
Sasajima H
Mineura K
Nishimura T
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Źródło :
Neuroreport [Neuroreport] 2010 Sep 15; Vol. 21 (13), pp. 851-5.
Typ publikacji :
Journal Article
MeSH Terms :
Body Temperature/*physiology
Brain/*physiology
Moyamoya Disease/*physiopathology
Adolescent ; Adult ; Aging/physiology ; Carotid Artery, Internal/physiology ; Female ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Posterior Cerebral Artery/physiology ; Retrospective Studies ; Young Adult
Czasopismo naukowe
Tytuł :
Disturbances in the secretion of neurotransmitters in IA-2/IA-2beta null mice: changes in behavior, learning and lifespan.
Autorzy :
Nishimura T; Experimental Medicine Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892-4322, USA.
Kubosaki A
Ito Y
Notkins AL
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Źródło :
Neuroscience [Neuroscience] 2009 Mar 17; Vol. 159 (2), pp. 427-37.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Behavior, Animal/*physiology
Brain/*metabolism
Conditioning, Psychological/*physiology
Neurotransmitter Agents/*metabolism
Protein Tyrosine Phosphatase, Non-Receptor Type 1/*deficiency
Receptor-Like Protein Tyrosine Phosphatases, Class 8/*deficiency
Age Factors ; Animals ; Antidepressive Agents, Second-Generation/pharmacology ; Biotinylation/methods ; Brain/ultrastructure ; Cells, Cultured ; Drinking/genetics ; Exploratory Behavior/physiology ; Female ; Hindlimb Suspension/physiology ; Insulin/metabolism ; Insulin Secretion ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Motor Activity/genetics ; Neurons/metabolism ; Neurons/ultrastructure ; Pentylenetetrazole ; Reaction Time/genetics ; Rotarod Performance Test/methods ; Secretory Vesicles/drug effects ; Secretory Vesicles/metabolism ; Seizures/chemically induced ; Seizures/genetics ; Synapsins/metabolism ; Synaptic Vesicles/drug effects ; Synaptic Vesicles/metabolism ; Synaptosomes/metabolism
Czasopismo naukowe
Tytuł :
MR tractography: a review of its clinical applications.
Autorzy :
Yamada K; Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan. />Sakai K
Akazawa K
Yuen S
Nishimura T
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Źródło :
Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine [Magn Reson Med Sci] 2009; Vol. 8 (4), pp. 165-74.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Brain/*pathology
Brain Diseases/*pathology
Diffusion Tensor Imaging/*methods
Humans ; Image Processing, Computer-Assisted/methods ; Neural Pathways/pathology
Czasopismo naukowe
Tytuł :
Diffusion anisotropy measurement of brain white matter is affected by voxel size: underestimation occurs in areas with crossing fibers.
Autorzy :
Oouchi H; Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto City, Kyoto, Japan.
Yamada K
Sakai K
Kizu O
Kubota T
Ito H
Nishimura T
Pokaż więcej
Źródło :
AJNR. American journal of neuroradiology [AJNR Am J Neuroradiol] 2007 Jun-Jul; Vol. 28 (6), pp. 1102-6.
Typ publikacji :
Evaluation Study; Journal Article
MeSH Terms :
Artifacts*
Brain/*anatomy & histology
Diffusion Magnetic Resonance Imaging/*methods
Image Interpretation, Computer-Assisted/*methods
Imaging, Three-Dimensional/*methods
Nerve Fibers, Myelinated/*ultrastructure
Adult ; Anisotropy ; Female ; Humans ; Image Enhancement/methods ; Male ; Middle Aged ; Reproducibility of Results ; Sensitivity and Specificity
Czasopismo naukowe
Tytuł :
Regional cerebral blood flow in Alzheimer's disease: comparison between short and long-term donepezil therapy.
Autorzy :
Ushuijima Y; Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan. />Okuyama C
Mori S
Kubota T
Nakai T
Nishimura T
Pokaż więcej
Źródło :
Annals of nuclear medicine [Ann Nucl Med] 2006 Jul; Vol. 20 (6), pp. 425-9.
Typ publikacji :
Comparative Study; Controlled Clinical Trial; Journal Article
MeSH Terms :
Alzheimer Disease/*diagnostic imaging
Alzheimer Disease/*drug therapy
Brain/*blood supply
Brain/*drug effects
Cerebrovascular Circulation/*drug effects
Indans/*administration & dosage
Piperidines/*administration & dosage
Aged ; Aged, 80 and over ; Brain/diagnostic imaging ; Donepezil ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Female ; Humans ; Male ; Middle Aged ; Nootropic Agents/administration & dosage ; Radionuclide Imaging ; Treatment Outcome
Czasopismo naukowe
Tytuł :
A region-of-interest template for three-dimensional stereotactic surface projection images: initial application to the analysis of Alzheimer's disease and mild cognitive impairment.
Autorzy :
Kubota T; Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan. />Ushijima Y
Okuyama C
Nishimura T
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Źródło :
Nuclear medicine communications [Nucl Med Commun] 2006 Jan; Vol. 27 (1), pp. 37-44.
Typ publikacji :
Controlled Clinical Trial; Journal Article
MeSH Terms :
Alzheimer Disease/*diagnostic imaging
Brain/*diagnostic imaging
Brain Mapping/*methods
Cognition Disorders/*diagnostic imaging
Image Interpretation, Computer-Assisted/*methods
Imaging, Three-Dimensional/*methods
Tomography, Emission-Computed, Single-Photon/*methods
Adult ; Aged ; Algorithms ; Alzheimer Disease/complications ; Brain/physiopathology ; Cognition Disorders/etiology ; Female ; Humans ; Male ; Pattern Recognition, Automated/methods ; Reproducibility of Results ; Sensitivity and Specificity ; Subtraction Technique
Czasopismo naukowe
Tytuł :
Diagnosis of Alzheimer's disease using brain perfusion SPECT and MR imaging: which modality achieves better diagnostic accuracy?
Autorzy :
Kubota T; Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Radiology, Kyoto, Japan. />Ushijima Y
Yamada K
Okuyama C
Kizu O
Nishimura T
Pokaż więcej
Źródło :
European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2005 Apr; Vol. 32 (4), pp. 414-21. Date of Electronic Publication: 2004 Nov 20.
Typ publikacji :
Clinical Trial; Controlled Clinical Trial; Journal Article
MeSH Terms :
Iofetamine*
Alzheimer Disease/*diagnosis
Brain/*blood supply
Brain/*diagnostic imaging
Magnetic Resonance Imaging/*methods
Tomography, Emission-Computed, Single-Photon/*methods
Aged ; Alzheimer Disease/diagnostic imaging ; Brain Mapping/methods ; Cerebrovascular Circulation ; Female ; Humans ; Imaging, Three-Dimensional/methods ; Male ; Observer Variation ; Radiopharmaceuticals ; Reproducibility of Results ; Sensitivity and Specificity
Czasopismo naukowe

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