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Wyszukujesz frazę ""Nisoldipine"" wg kryterium: Temat


Tytuł :
Enhanced bioavailability and antihypertensive activity of nisoldipine loaded nanoemulsion: optimization, cytotoxicity and uptake across Caco-2 cell line, pharmacokinetic and pharmacodynamic studies.
Autorzy :
Mundada VP; Drug Delivery Research Laboratory, Centre of Relevance and Excellence in NDDS, Faculty of Pharmacy, The Maharaja Sayajirao University of Baroda, Vadodara, India.
Patel MH; Drug Delivery Research Laboratory, Centre of Relevance and Excellence in NDDS, Faculty of Pharmacy, The Maharaja Sayajirao University of Baroda, Vadodara, India.
Mundada PK; Drug Delivery Research Laboratory, Centre of Relevance and Excellence in NDDS, Faculty of Pharmacy, The Maharaja Sayajirao University of Baroda, Vadodara, India.
Sawant KK; Drug Delivery Research Laboratory, Centre of Relevance and Excellence in NDDS, Faculty of Pharmacy, The Maharaja Sayajirao University of Baroda, Vadodara, India.
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Źródło :
Drug development and industrial pharmacy [Drug Dev Ind Pharm] 2020 Mar; Vol. 46 (3), pp. 376-387. Date of Electronic Publication: 2020 Feb 13.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Nanoparticles*
Antihypertensive Agents/*administration & dosage
Hypertension/*drug therapy
Nisoldipine/*administration & dosage
Administration, Oral ; Animals ; Antihypertensive Agents/pharmacokinetics ; Antihypertensive Agents/pharmacology ; Biological Availability ; Caco-2 Cells ; Disease Models, Animal ; Drug Delivery Systems ; Drug Liberation ; Emulsions ; Excipients/chemistry ; Humans ; Intestinal Absorption ; Male ; Nisoldipine/pharmacokinetics ; Nisoldipine/pharmacology ; Particle Size ; Rats ; Rats, Sprague-Dawley ; Surface-Active Agents/chemistry
Czasopismo naukowe
Tytuł :
Effects of m-nisoldipine on the activity and mRNA expression of four CYP isozymes in rats.
Autorzy :
Sun Y; a Department of Pharmaceutical Analysis and.
Liu Y; a Department of Pharmaceutical Analysis and.
Zhang X; a Department of Pharmaceutical Analysis and.
Wan C; a Department of Pharmaceutical Analysis and.
Lyu T; b Pharmaceutical Experimental Center, School of Pharmacy, Hebei Medical University , Shijiazhuang , PR China.
Zhang L; a Department of Pharmaceutical Analysis and.
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Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2018 Jul; Vol. 48 (7), pp. 676-683. Date of Electronic Publication: 2017 Aug 04.
Typ publikacji :
Journal Article
MeSH Terms :
Cytochrome P-450 Enzyme System/*genetics
Gene Expression Regulation, Enzymologic/*drug effects
Nisoldipine/*pharmacology
Animals ; Aryl Hydrocarbon Hydroxylases ; Cytochrome P-450 CYP1A2/metabolism ; Cytochrome P-450 CYP3A/metabolism ; Cytochrome P-450 Enzyme System/metabolism ; Cytochrome P450 Family 2/metabolism ; Male ; Midazolam/pharmacokinetics ; Molecular Probes/chemistry ; Nisoldipine/blood ; Nisoldipine/chemistry ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats, Sprague-Dawley ; Steroid 16-alpha-Hydroxylase ; Time Factors
Czasopismo naukowe
Tytuł :
Comparative study of nisoldipine-loaded nanostructured lipid carriers and solid lipid nanoparticles for oral delivery: preparation, characterization, permeation and pharmacokinetic evaluation.
Autorzy :
Dudhipala N; a Department of Pharmaceutics , Vaagdevi Pharmacy College , Warangal , Telangana , India.
Janga KY; b Department of Pharmaceutics , KIPS , Warangal , Telangana , India.
Gorre T; a Department of Pharmaceutics , Vaagdevi Pharmacy College , Warangal , Telangana , India.
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Źródło :
Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2018; Vol. 46 (sup2), pp. 616-625. Date of Electronic Publication: 2018 Apr 24.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Intestinal Absorption*
Drug Carriers/*chemistry
Lipids/*chemistry
Nanoparticles/*chemistry
Nisoldipine/*chemistry
Nisoldipine/*metabolism
Administration, Oral ; Animals ; Biological Availability ; Drug Liberation ; Male ; Nisoldipine/administration & dosage ; Nisoldipine/pharmacokinetics ; Particle Size ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Comparative evaluation of proliposomes and self micro-emulsifying drug delivery system for improved oral bioavailability of nisoldipine.
Autorzy :
Nekkanti V; Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA, USA; College of Pharmacy, Western University of Health Sciences, Pomona, CA, USA. Electronic address: .
Rueda J; College of Pharmacy, Western University of Health Sciences, Pomona, CA, USA.
Wang Z; College of Pharmacy, Western University of Health Sciences, Pomona, CA, USA.
Betageri GV; Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA, USA; College of Pharmacy, Western University of Health Sciences, Pomona, CA, USA.
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Źródło :
International journal of pharmaceutics [Int J Pharm] 2016 May 30; Vol. 505 (1-2), pp. 79-88. Date of Electronic Publication: 2016 Mar 31.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Drug Delivery Systems*
Drug Carriers/*chemistry
Lipids/*chemistry
Nisoldipine/*administration & dosage
Administration, Oral ; Animals ; Biological Availability ; Chemistry, Pharmaceutical/methods ; Drug Liberation ; Emulsions ; Excipients/chemistry ; Liposomes ; Male ; Nisoldipine/pharmacokinetics ; Particle Size ; Permeability ; Rats ; Rats, Sprague-Dawley ; Solubility
Czasopismo naukowe
Tytuł :
Polymeric behavior evaluation of PVP K30-poloxamer binary carrier for solid dispersed nisoldipine by experimental design.
Autorzy :
Kyaw Oo M; a Department of Pharmaceutical Technology , Kulliyyah of Pharmacy, International Islamic University Malaysia , Kuantan , Malaysia.
Mandal UK; a Department of Pharmaceutical Technology , Kulliyyah of Pharmacy, International Islamic University Malaysia , Kuantan , Malaysia.
Chatterjee B; a Department of Pharmaceutical Technology , Kulliyyah of Pharmacy, International Islamic University Malaysia , Kuantan , Malaysia.
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Źródło :
Pharmaceutical development and technology [Pharm Dev Technol] 2017 Feb; Vol. 22 (1), pp. 2-12. Date of Electronic Publication: 2015 Nov 29.
Typ publikacji :
Journal Article
MeSH Terms :
Antihypertensive Agents/*administration & dosage
Drug Carriers/*chemistry
Nisoldipine/*administration & dosage
Poloxamer/*chemistry
Povidone/*chemistry
Antihypertensive Agents/chemistry ; Calorimetry, Differential Scanning ; Chemistry, Pharmaceutical ; Excipients/chemistry ; Nisoldipine/chemistry ; Plasticizers/chemistry ; Solubility ; Spectroscopy, Fourier Transform Infrared ; Tablets ; Tensile Strength
Czasopismo naukowe
Tytuł :
Investigating the in vitro stereoselective metabolism of m-nisoldipine enantiomers: characterization of metabolites and cytochrome P450 isoforms involved.
Autorzy :
Sun Y; Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, People's Republic of China.
Jia P; Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, People's Republic of China.
Yuan L; Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, People's Republic of China.
Liu Y; Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, People's Republic of China.
Zhang Z; Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, People's Republic of China.
Du Y; Department of Medicinal Chemistry, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, People's Republic of China.
Zhang L; Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, People's Republic of China.
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Źródło :
Biomedical chromatography : BMC [Biomed Chromatogr] 2015 Dec; Vol. 29 (12), pp. 1893-900. Date of Electronic Publication: 2015 Jun 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytochrome P-450 Enzyme System/*metabolism
Microsomes, Liver/*metabolism
Nisoldipine/*analysis
Nisoldipine/*metabolism
Animals ; Chromatography, High Pressure Liquid ; Cytochrome P-450 Enzyme Inhibitors/pharmacology ; Cytochrome P-450 Enzyme System/drug effects ; Male ; Nisoldipine/chemistry ; Rats ; Rats, Sprague-Dawley ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Stereoisomerism
Czasopismo naukowe
Tytuł :
On the dimorphism and the pressure-temperature state diagram of racemic m-nisoldipine, a dihydropyridine calcium ion antagonist.
Autorzy :
Li K; Laboratoire SMS, EA 3233, Normandie université, université de Rouen, 76821 Mont-Saint-Aignan, France.
Gbabode G; Laboratoire SMS, EA 3233, Normandie université, université de Rouen, 76821 Mont-Saint-Aignan, France.
Coquerel G; Laboratoire SMS, EA 3233, Normandie université, université de Rouen, 76821 Mont-Saint-Aignan, France.
Céolin R; LETIAM, EA7357, IUT Orsay, université Paris-Sud, rue Noetzlin, 91405 Orsay cedex, France.
Rietveld IB; Laboratoire SMS, EA 3233, Normandie université, université de Rouen, 76821 Mont-Saint-Aignan, France; Faculté de pharmacie, université Paris-Descartes, USPC, 4, avenue de l'observatoire, 75006 Paris, France. Electronic address: .
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Źródło :
Annales pharmaceutiques francaises [Ann Pharm Fr] 2018 Sep; Vol. 76 (5), pp. 341-347. Date of Electronic Publication: 2018 May 21.
Typ publikacji :
Journal Article
MeSH Terms :
Calcium Channel Blockers/*chemistry
Nisoldipine/*chemistry
Crystallization ; Drug Stability ; Pressure ; Stereoisomerism ; Temperature ; Thermodynamics
Czasopismo naukowe
Tytuł :
Transdermal Delivery of Nisoldipine: Refinement of Vehicles.
Autorzy :
El Maghraby GM
Ahmed AA
Osman MA
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Źródło :
International journal of pharmaceutical compounding [Int J Pharm Compd] 2015 Mar-Apr; Vol. 19 (2), pp. 152-60.
Typ publikacji :
Journal Article
MeSH Terms :
Pharmaceutical Vehicles*
Calcium Channel Blockers/*administration & dosage
Nisoldipine/*administration & dosage
Administration, Cutaneous ; Chemistry, Pharmaceutical ; Emulsions ; Nisoldipine/chemistry ; Solubility
Czasopismo naukowe
Tytuł :
The inhibitor of connexin Cx36 channels, mefloquine, inhibits voltage-dependent Ca channels and insulin secretion.
Autorzy :
Seemann N; Institute of Pharmacology and Toxicology, Technische Universität Braunschweig, D-38106 Braunschweig, Germany.
Welling A; Institute of Pharmacology and Toxicology, Technische Universität München, D-80802 München, Germany.
Rustenbeck I; Institute of Pharmacology and Toxicology, Technische Universität Braunschweig, D-38106 Braunschweig, Germany. Electronic address: .
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Źródło :
Molecular and cellular endocrinology [Mol Cell Endocrinol] 2018 Sep 05; Vol. 472, pp. 97-106. Date of Electronic Publication: 2017 Dec 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium Channels/*metabolism
Connexins/*antagonists & inhibitors
Insulin Secretion/*drug effects
Mefloquine/*pharmacology
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester/pharmacology ; Action Potentials/drug effects ; Animals ; Calcium/metabolism ; Calcium Channel Blockers/pharmacology ; Connexins/metabolism ; Dihydropyridines/pharmacology ; Glucose/pharmacology ; Insulin-Secreting Cells/drug effects ; Insulin-Secreting Cells/metabolism ; Ion Channel Gating/drug effects ; Mice ; Nisoldipine/pharmacology ; Potassium Chloride/pharmacology ; Tolbutamide/pharmacology
Czasopismo naukowe
Tytuł :
Studies on separation and pharmacokinetics of m-nisoldipine enantiomers in beagle dog plasma by LC/MS/MS.
Autorzy :
Li M; Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, PR China.
Yuan L
Li X
Zhi X
Sheng N
Zhang L
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Źródło :
Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2013 Nov; Vol. 85, pp. 61-6. Date of Electronic Publication: 2013 Jul 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromatography, Liquid/*methods
Nisoldipine/*isolation & purification
Nisoldipine/*pharmacokinetics
Tandem Mass Spectrometry/*methods
Animals ; Calibration ; Dogs ; Drug Stability ; Female ; Male ; Nisoldipine/chemistry ; Spectrometry, Mass, Electrospray Ionization ; Stereoisomerism
Czasopismo naukowe
Tytuł :
Regulation of Spontaneous Contractions in Intact Rat Bladder Strips and the Effects of Hydrogen Peroxide.
Autorzy :
Wang M; Department of Surgery, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA.; Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Xing N; Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Wu L; Department of Surgery, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA.; Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Huang WC; Department of Surgery, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA.; Division of Urogynecology, Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan.
Xu Z; Department of Surgery, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA.; Department of Urology, Shengjing Hospital, China Medical University, Shenyang, China.
Liu G; Department of Surgery, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA.
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Źródło :
BioMed research international [Biomed Res Int] 2018 Feb 04; Vol. 2018, pp. 2925985. Date of Electronic Publication: 2018 Feb 04 (Print Publication: 2018).
Typ publikacji :
Journal Article
MeSH Terms :
Hydrogen Peroxide/*administration & dosage
Muscle Contraction/*drug effects
Urinary Bladder/*drug effects
Urinary Bladder, Overactive/*drug therapy
Amides/administration & dosage ; Animals ; Imidazoles/administration & dosage ; Indoles/administration & dosage ; Male ; Maleimides/administration & dosage ; Muscle, Smooth/drug effects ; Nisoldipine/administration & dosage ; Oximes/administration & dosage ; Pyridines/administration & dosage ; Rats ; Ryanodine/administration & dosage ; Small-Conductance Calcium-Activated Potassium Channels/genetics ; Urinary Bladder/physiology ; Urinary Bladder, Overactive/physiopathology ; rho-Associated Kinases/genetics
Czasopismo naukowe
Tytuł :
Effect of nisoldipine and olmesartan on endothelium-dependent vasodilation in essential hypertensive patients.
Autorzy :
Wei D; Department of Pharmacy, Zhongshan, Hospital, Fudan University, Shanghai, China.
He WY
Lv QZ
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Źródło :
CNS neuroscience & therapeutics [CNS Neurosci Ther] 2012 May; Vol. 18 (5), pp. 400-5.
Typ publikacji :
Journal Article; Randomized Controlled Trial
MeSH Terms :
Antihypertensive Agents/*pharmacology
Endothelium/*blood supply
Hypertension/*pathology
Imidazoles/*pharmacology
Nisoldipine/*pharmacology
Tetrazoles/*pharmacology
Vasodilation/*drug effects
Aged ; Anthracenes ; Antihypertensive Agents/therapeutic use ; Arginine/analogs & derivatives ; Arginine/blood ; Blood Pressure/drug effects ; C-Reactive Protein/metabolism ; Case-Control Studies ; Endothelin-1/blood ; Endothelium/drug effects ; Female ; Humans ; Hypertension/blood ; Hypertension/drug therapy ; Imidazoles/therapeutic use ; Male ; Middle Aged ; Nisoldipine/therapeutic use ; Nitric Oxide/blood ; Propane/analogs & derivatives ; Propane/blood ; Prostaglandins F/blood ; Single-Blind Method ; Tetrazoles/therapeutic use
Czasopismo naukowe
Tytuł :
Simultaneous determination of m-nisoldipine and its three metabolites in rat plasma by liquid chromatography-mass spectrometry.
Autorzy :
Kong D; Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China.
Li S
Zhang X
Gu J
Liu M
Meng Y
Fu Y
La X
Xue G
Zhang L
Wang Q
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Źródło :
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2010 Nov 01; Vol. 878 (29), pp. 2989-96. Date of Electronic Publication: 2010 Sep 15.
Typ publikacji :
Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromatography, Liquid/*methods
Nisoldipine/*blood
Nisoldipine/*metabolism
Tandem Mass Spectrometry/*methods
Animals ; Male ; Molecular Structure ; Nisoldipine/chemistry ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Preparation of a novel glycidyl methacrylate-based monolith and its application for the determination of m-nisoldipine in human plasma.
Autorzy :
Zhang Q; Key Laboratory for Drug Quality Control and Analysis of Hebei Province, College of Pharmacy, Hebei University, Baoding 071002, China.
Yang G
Liu H
Yang J
Yan Y
Bai L
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Źródło :
Journal of chromatographic science [J Chromatogr Sci] 2010 Jul; Vol. 48 (6), pp. 517-22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromatography, High Pressure Liquid/*methods
Chromatography, Reverse-Phase/*methods
Epoxy Compounds/*chemistry
Methacrylates/*chemistry
Nisoldipine/*blood
Animals ; Emulsions ; Epoxy Compounds/chemical synthesis ; Humans ; Linear Models ; Male ; Methacrylates/chemical synthesis ; Mice ; Microscopy, Electron, Scanning ; Nisoldipine/chemistry ; Nisoldipine/pharmacokinetics ; Reproducibility of Results ; Sensitivity and Specificity ; Spectroscopy, Fourier Transform Infrared
Czasopismo naukowe

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