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Wyszukujesz frazę ""Nitric Oxide Synthase Type II"" wg kryterium: Temat


Tytuł :
Selective Inhibitors of the Inducible Nitric Oxide Synthase as Modulators of Cell Responses in LPS-Stimulated Human Monocytes.
Autorzy :
Gallorini M; Department of Pharmacy, University 'G. d'Annunzio' Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy.
Rapino M; Genetic Molecular Institute of CNR, Unit of Chieti, 'G. d' Annunzio' University, Via dei Vestini 31, 66100 Chieti, Italy.
Schweikl H; Department of Conservative Dentistry and Periodontology, University Hospital Regensburg, D-93042 Regensburg, Germany.
Cataldi A; Department of Pharmacy, University 'G. d'Annunzio' Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy.
Amoroso R; Department of Pharmacy, University 'G. d'Annunzio' Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy.
Maccallini C; Department of Pharmacy, University 'G. d'Annunzio' Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Jul 22; Vol. 26 (15). Date of Electronic Publication: 2021 Jul 22.
Typ publikacji :
Journal Article
MeSH Terms :
Nitric Oxide Synthase Type II*/antagonists & inhibitors
Nitric Oxide Synthase Type II*/metabolism
Amidines/*pharmacology
Enzyme Inhibitors/*pharmacology
Lipopolysaccharides/*toxicity
Monocytes/*enzymology
Proline/*analogs & derivatives
Humans ; Interleukin-6/metabolism ; NF-E2-Related Factor 2/metabolism ; Proline/pharmacology
Czasopismo naukowe
Tytuł :
Inhibition of inducible nitric oxide synthase improved erectile dysfunction in rats with type 1 diabetes.
Autorzy :
Liu L; Department of Urology, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin, China.
Wang X; Department of Urology, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin, China.
Liu K; Department of Urology, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin, China.
Kang J; Department of Urology, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin, China.
Wang S; Department of Urology, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin, China.
Song Y; Department of Urology, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin, China.
Zhou K; Department of Urology, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin, China.
Yi L; Department of Urology, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin, China.
Liu X; Department of Urology, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin, China.
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Źródło :
Andrologia [Andrologia] 2021 Sep; Vol. 53 (8), pp. e14138. Date of Electronic Publication: 2021 Jun 16.
Typ publikacji :
Journal Article
MeSH Terms :
Diabetes Mellitus, Experimental*/complications
Diabetes Mellitus, Type 1*/complications
Erectile Dysfunction*/drug therapy
Erectile Dysfunction*/etiology
Nitric Oxide Synthase Type II/*metabolism
Animals ; Male ; Nitric Oxide ; Nitric Oxide Synthase Type II/antagonists & inhibitors ; Penile Erection ; Penis/metabolism ; Rats
Czasopismo naukowe
Tytuł :
More than just protein building blocks: how amino acids and related metabolic pathways fuel macrophage polarization.
Autorzy :
Kieler M; Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria.; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria.
Hofmann M; Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria.; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria.
Schabbauer G; Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria.; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria.
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Źródło :
The FEBS journal [FEBS J] 2021 Jun; Vol. 288 (12), pp. 3694-3714. Date of Electronic Publication: 2021 Feb 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Arginase/*metabolism
Arginine/*metabolism
Glutamine/*metabolism
Glycine/*immunology
Macrophages/*metabolism
Nitric Oxide Synthase Type II/*metabolism
Serine/*metabolism
Arginase/genetics ; Arginase/immunology ; Arginine/immunology ; Cell Differentiation/drug effects ; Citric Acid Cycle/genetics ; Citric Acid Cycle/immunology ; Gene Expression Regulation ; Glutamine/immunology ; Glycine/metabolism ; Humans ; Immunity, Innate ; Interferon-gamma/pharmacology ; Lipopolysaccharides/pharmacology ; Macrophage Activation/drug effects ; Macrophages/classification ; Macrophages/drug effects ; Macrophages/immunology ; Mitochondria/drug effects ; Mitochondria/immunology ; Mitochondria/metabolism ; Nitric Oxide/immunology ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type II/genetics ; Nitric Oxide Synthase Type II/immunology ; Oxidative Phosphorylation ; Serine/immunology
Czasopismo naukowe
Tytuł :
Novel chalcone/aryl carboximidamide hybrids as potent anti-inflammatory via inhibition of prostaglandin E2 and inducible NO synthase activities: design, synthesis, molecular docking studies and ADMET prediction.
Autorzy :
Ibrahim TS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
Moustafa AH; Department of Chemistry, Faculty of Science, Sohag University, Sohag, Egypt.
Almalki AJ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Allam RM; Pharmacology Department, National Research Centre, Cairo, Egypt.
Althagafi A; Department of Pharmacy Practice, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Md S; Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Mohamed MFA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, Sohag, Egypt.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 1067-1078.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Molecular Docking Simulation*
Amides/*pharmacology
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Chalcone/*pharmacology
Dinoprostone/*antagonists & inhibitors
Edema/*drug therapy
Enzyme Inhibitors/*pharmacology
Nitric Oxide Synthase Type II/*antagonists & inhibitors
Amides/chemical synthesis ; Amides/chemistry ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Carrageenan ; Cells, Cultured ; Chalcone/chemical synthesis ; Chalcone/chemistry ; Dinoprostone/metabolism ; Dose-Response Relationship, Drug ; Edema/chemically induced ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Mice ; Molecular Structure ; Nitric Oxide Synthase Type II/metabolism ; RAW 264.7 Cells ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Optimization of N -Phenylpropenoyl-l-amino Acids as Potent and Selective Inducible Nitric Oxide Synthase Inhibitors for Parkinson's Disease.
Autorzy :
Hu XL; State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China.
Lv XY; State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China.
Wang R; State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China.
Long H; State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China.
Feng JH; State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China.
Wang BL; State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China.
Shen W; State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China.
Liu H; State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China.
Xiong F; State Key Laboratory of Bioelectronics, Jiangsu Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210009, People's Republic of China.
Zhang XQ; Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, People's Republic of China.
Ye WC; Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, People's Republic of China.
Wang H; State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Jun 10; Vol. 64 (11), pp. 7760-7777. Date of Electronic Publication: 2021 May 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amino Acids/*chemistry
Nitric Oxide Synthase Type II/*antagonists & inhibitors
Propanols/*chemistry
Amino Acids/metabolism ; Amino Acids/pharmacology ; Animals ; Binding Sites ; Blood-Brain Barrier/drug effects ; Blood-Brain Barrier/metabolism ; Disease Models, Animal ; Dopaminergic Neurons/drug effects ; Dopaminergic Neurons/metabolism ; Drug Design ; Half-Life ; Humans ; Isoenzymes/antagonists & inhibitors ; Isoenzymes/metabolism ; MPTP Poisoning/drug therapy ; MPTP Poisoning/pathology ; Maze Learning/drug effects ; Mice ; Mice, Inbred C57BL ; Microglia/cytology ; Microglia/drug effects ; Microglia/metabolism ; Molecular Docking Simulation ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type II/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Implications of SARS-Cov-2 infection on eNOS and iNOS activity: Consequences for the respiratory and vascular systems.
Autorzy :
Guimarães LMF; Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, SP, Brazil.
Rossini CVT; Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, SP, Brazil.
Lameu C; Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, SP, Brazil. Electronic address: .
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Źródło :
Nitric oxide : biology and chemistry [Nitric Oxide] 2021 Jun 01; Vol. 111-112, pp. 64-71. Date of Electronic Publication: 2021 Apr 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
SARS-CoV-2*
COVID-19/*metabolism
Nitric Oxide/*metabolism
Nitric Oxide Synthase Type II/*metabolism
Nitric Oxide Synthase Type III/*metabolism
Blood Vessels/metabolism ; Gene Expression Regulation, Enzymologic ; Humans ; Nitric Oxide Synthase Type II/genetics ; Nitric Oxide Synthase Type III/genetics ; Respiratory System/metabolism
Czasopismo naukowe
Tytuł :
Danlou Fang reduces microvascular obstruction through the endothelial/inducible nitric oxide synthase pathway in a rat model.
Autorzy :
Dai X; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Chen R; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Chen T; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Yan H; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Wang Y; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Zhou K; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Zhang X; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Wang Y; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
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Źródło :
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan [J Tradit Chin Med] 2021 Apr; Vol. 41 (2), pp. 246-253.
Typ publikacji :
Journal Article
MeSH Terms :
Drugs, Chinese Herbal/*administration & dosage
Myocardial Infarction/*drug therapy
Nitric Oxide Synthase Type II/*metabolism
Nitric Oxide Synthase Type III/*metabolism
Animals ; Humans ; Male ; Malondialdehyde/metabolism ; Myocardial Infarction/genetics ; Myocardial Infarction/metabolism ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type II/genetics ; Nitric Oxide Synthase Type III/genetics ; Rats ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism ; Superoxide Dismutase/metabolism
Czasopismo naukowe
Tytuł :
Inhibition of Inducible Nitric Oxide Synthase (iNOS) by Andrographolide and In Vitro Evaluation of Its Antiproliferative and Proapoptotic Effects on Cervical Cancer.
Autorzy :
Pasha A; Department of Genetics & Biotechnology, University College of Science, Osmania University, Hyderabad, 500 007 Telangana, India.
Kumbhakar DV; Department of Genetics & Biotechnology, University College of Science, Osmania University, Hyderabad, 500 007 Telangana, India.
Doneti R; Department of Genetics & Biotechnology, University College of Science, Osmania University, Hyderabad, 500 007 Telangana, India.
Kumar K; Department of Bioinformatics, School of Biosciences & Technology, Vellore Institute of Technology, Vellore, Tamil Nadu 632014, India.
Dharmapuri G; Department of Animal Biology, School of Life Sciences, University of Hyderabad, Hyderabad, 500 046 Telangana, India.
Poleboyina PK; Department of Genetics & Biotechnology, University College of Science, Osmania University, Hyderabad, 500 007 Telangana, India.
S K H; Department of Pathology, Osmania Medical College, Hyderabad, 500095 Telangana, India.
Basavaraju P; Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, 641046 Tamil Nadu, India.
Pasumarthi D; Department of Genetics & Biotechnology, University College of Science, Osmania University, Hyderabad, 500 007 Telangana, India.
S D A; Department of Genetics & Biotechnology, University College of Science, Osmania University, Hyderabad, 500 007 Telangana, India.
Soujanya P; Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad, 500007 Telangana, India.
Arnold Emeson I; Department of Bioinformatics, School of Biosciences & Technology, Vellore Institute of Technology, Vellore, Tamil Nadu 632014, India.
Bodiga V; Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad, 500007 Telangana, India.
Pawar SC; Department of Genetics & Biotechnology, University College of Science, Osmania University, Hyderabad, 500 007 Telangana, India.
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Źródło :
Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2021 Mar 16; Vol. 2021, pp. 6692628. Date of Electronic Publication: 2021 Mar 16 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*/drug effects
Diterpenes/*pharmacology
Nitric Oxide Synthase Type II/*antagonists & inhibitors
Uterine Cervical Neoplasms/*pathology
Adult ; Animals ; Cell Cycle/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Female ; Gene Expression Regulation, Enzymologic/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; HEK293 Cells ; HeLa Cells ; Humans ; Ligands ; Middle Aged ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Nitric Oxide Synthase Type II/genetics ; Nitric Oxide Synthase Type II/metabolism ; Reproducibility of Results ; Thermodynamics ; Uterine Cervical Neoplasms/genetics ; Wound Healing/drug effects
Czasopismo naukowe
Tytuł :
Expression of Nitric Oxide Synthase and Nitric Oxide Levels in Peripheral Blood Cells and Oxidized Low-Density Lipoprotein Levels in Saliva as Early Markers of Severe Dengue.
Autorzy :
Hapugaswatta H; Department of Chemistry, Faculty of Science, University of Kelaniya, Kelaniya, Sri Lanka.
Wimalasekara RL; Department of Chemistry, Faculty of Science, University of Kelaniya, Kelaniya, Sri Lanka.
Perera SS; North Colombo Teaching Hospital, Ragama, Sri Lanka.
Premaratna R; North Colombo Teaching Hospital, Ragama, Sri Lanka.; Department of Medicine, Faculty of Medicine, University of Kelaniya, Kelaniya, Sri Lanka.
Seneviratne KN; Department of Chemistry, Faculty of Science, University of Kelaniya, Kelaniya, Sri Lanka.
Jayathilaka N; Department of Chemistry, Faculty of Science, University of Kelaniya, Kelaniya, Sri Lanka.
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Źródło :
BioMed research international [Biomed Res Int] 2021 Feb 09; Vol. 2021, pp. 6650596. Date of Electronic Publication: 2021 Feb 09 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Severe Dengue*/diagnosis
Severe Dengue*/epidemiology
Severe Dengue*/genetics
Severe Dengue*/metabolism
Lipoproteins, LDL/*analysis
Nitric Oxide/*analysis
Nitric Oxide Synthase Type II/*blood
Saliva/*chemistry
Adolescent ; Adult ; Biomarkers/analysis ; Biomarkers/blood ; Biomarkers/metabolism ; Case-Control Studies ; Female ; Humans ; Male ; Middle Aged ; Nitric Oxide Synthase Type II/genetics ; Nitric Oxide Synthase Type II/metabolism ; Retrospective Studies ; Sensitivity and Specificity ; Young Adult
Czasopismo naukowe
Tytuł :
Bioactive sesquiterpene derivatives from mangrove endophytic fungus Phomopsis sp. SYSU-QYP-23: Structures and nitric oxide inhibitory activities.
Autorzy :
Chen Y; School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, PR China; National R & D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, China.
Liu H; School of Pharmacy, Guangdong Medical University, Dongguan 523808, PR China.
Zou G; School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, PR China.
Yang W; School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, PR China.
Zhang L; School of Pharmacy, Guangdong Medical University, Dongguan 523808, PR China.
Yan Z; School of Chemistry, South China Normal University, Guangzhou 510006, PR China.
Long Y; School of Chemistry, South China Normal University, Guangzhou 510006, PR China. Electronic address: .
She Z; School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, PR China. Electronic address: .
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2021 Feb; Vol. 107, pp. 104530. Date of Electronic Publication: 2020 Dec 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Enzyme Inhibitors/*pharmacology
Nitric Oxide/*antagonists & inhibitors
Nitric Oxide Synthase Type II/*antagonists & inhibitors
Phomopsis/*chemistry
Sesquiterpenes/*pharmacology
Animals ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/isolation & purification ; Enzyme Inhibitors/metabolism ; Humans ; Hydrogen Bonding ; Mice ; Molecular Docking Simulation ; Nitric Oxide Synthase Type II/chemistry ; Nitric Oxide Synthase Type II/metabolism ; Protein Binding ; RAW 264.7 Cells ; Sesquiterpenes/chemistry ; Sesquiterpenes/isolation & purification ; Sesquiterpenes/metabolism
Czasopismo naukowe
Tytuł :
Protection against Doxorubicin-Induced Cardiotoxicity through Modulating iNOS/ARG 2 Balance by Electroacupuncture at PC6.
Autorzy :
Wang J; South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
Yao L; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
Wu X; South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
Guo Q; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
Sun S; South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
Li J; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
Shi G; South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
Caldwell RB; Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Caldwell RW; Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Chen Y; South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.; Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong-Macao Greater Bay Area, Guangzhou 510515, China.
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Źródło :
Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2021 Mar 20; Vol. 2021, pp. 6628957. Date of Electronic Publication: 2021 Mar 20 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*toxicity
Arginase/*metabolism
Doxorubicin/*toxicity
Electroacupuncture/*methods
Heart Diseases/*prevention & control
Nitric Oxide Synthase Type II/*metabolism
Acupuncture Points ; Animals ; Arginase/genetics ; Cardiotoxicity/etiology ; Cardiotoxicity/parasitology ; Heart Diseases/etiology ; Male ; Mice ; Mice, Inbred C57BL ; Myocardium/metabolism ; Nitric Oxide Synthase Type II/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł :
Discovery and development of novel pyrimidine and pyrazolo/thieno-fused pyrimidine derivatives as potent and orally active inducible nitric oxide synthase dimerization inhibitor with efficacy for arthritis.
Autorzy :
Chen LZ; School of Pharmacy, Anhui Medical University, Hefei, 230032, PR China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, PR China.
Shu HY; School of Pharmacy, Anhui Medical University, Hefei, 230032, PR China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, PR China.
Wu J; School of Pharmacy, Anhui Medical University, Hefei, 230032, PR China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, PR China.
Yu YL; School of Pharmacy, Anhui Medical University, Hefei, 230032, PR China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, PR China.
Ma D; School of Pharmacy, Anhui Medical University, Hefei, 230032, PR China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, PR China.
Huang X; School of Pharmacy, Anhui Medical University, Hefei, 230032, PR China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, PR China.
Liu MM; School of Pharmacy, Anhui Medical University, Hefei, 230032, PR China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, PR China.
Liu XH; School of Pharmacy, Anhui Medical University, Hefei, 230032, PR China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, PR China. Electronic address: .
Shi JB; School of Pharmacy, Anhui Medical University, Hefei, 230032, PR China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, PR China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Mar 05; Vol. 213, pp. 113174. Date of Electronic Publication: 2021 Jan 20.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Development*
Arthritis/*drug therapy
Enzyme Inhibitors/*pharmacology
Nitric Oxide Synthase Type II/*antagonists & inhibitors
Pyrazoles/*pharmacology
Pyrimidines/*pharmacology
Administration, Oral ; Animals ; Arthritis/metabolism ; Cells, Cultured ; Dimerization ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/administration & dosage ; Enzyme Inhibitors/chemistry ; Freund's Adjuvant ; Humans ; Lipopolysaccharides/antagonists & inhibitors ; Lipopolysaccharides/pharmacology ; Male ; Mice ; Molecular Structure ; Nitric Oxide/antagonists & inhibitors ; Nitric Oxide/biosynthesis ; Nitric Oxide Synthase Type II/metabolism ; Pyrazoles/administration & dosage ; Pyrazoles/chemistry ; Pyrimidines/administration & dosage ; Pyrimidines/chemistry ; RAW 264.7 Cells ; Rats ; Rats, Sprague-Dawley ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Association between Genetic Variants in NOS2 and TNF Genes with Congenital Zika Syndrome and Severe Microcephaly.
Autorzy :
Gomes JA; Programa de Pós-Graduação em Genética e Biologia Molecular (PPGBM), Departamento de Genética, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 91501-970, Brazil.; Sistema Nacional de Informação sobre Agentes Teratogênicos (SIAT), Serviço de Genética Médica (SGM), Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre 90035-903, Brazil.; Instituto Nacional de Ciência e Tecnologia de Genética Médica Populacional (INAGEMP), Porto Alegre 90035-004, Brazil.; Laboratório de Medicina Genômica (LMG), Centro de Pesquisa Experimental (CPE), Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre 90035-903, Brazil.
Sgarioni E; Programa de Pós-Graduação em Genética e Biologia Molecular (PPGBM), Departamento de Genética, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 91501-970, Brazil.
Boquett JA; Programa de Pós-Graduação em Genética e Biologia Molecular (PPGBM), Departamento de Genética, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 91501-970, Brazil.; Instituto Nacional de Ciência e Tecnologia de Genética Médica Populacional (INAGEMP), Porto Alegre 90035-004, Brazil.
Terças-Trettel ACP; Departamento de Enfermagem, Universidade do Estado de Mato Grosso (UNEMAT), Tangará da Serra 78300-000, Brazil.
da Silva JH; Secretaria Municipal de Saúde de Tangará da Serra, Tangará da Serra 78300-000, Brazil.
Ribeiro BFR; Fundação Hospital de Clínicas do Acre (FUNDACRE), Rio Branco 69914-220, Brazil.
Galera MF; Departamento de Pediatria, Faculdade de Medicina, Universidade Federal de Mato Grosso (UFMT), Cuiabá 78048-902, Brazil.
de Oliveira TM; Hospital Universitário Júlio Müller (HUJM), Universidade Federal de Mato Grosso (UFMT), Empresa Brasileira de Serviços Hospitalares (EBSERH), Cuiabá 78048-902, Brazil.
Carvalho de Andrade MDF; Universidade Estadual do Ceará (UECE), Fortaleza 60741-000, Brazil.
Carvalho IF; Centro Universitário Christus (UNICHRISTUS), Fortaleza 60811-020, Brazil.
Schüler-Faccini L; Programa de Pós-Graduação em Genética e Biologia Molecular (PPGBM), Departamento de Genética, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 91501-970, Brazil.; Sistema Nacional de Informação sobre Agentes Teratogênicos (SIAT), Serviço de Genética Médica (SGM), Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre 90035-903, Brazil.; Instituto Nacional de Ciência e Tecnologia de Genética Médica Populacional (INAGEMP), Porto Alegre 90035-004, Brazil.
Vianna FSL; Programa de Pós-Graduação em Genética e Biologia Molecular (PPGBM), Departamento de Genética, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 91501-970, Brazil.; Sistema Nacional de Informação sobre Agentes Teratogênicos (SIAT), Serviço de Genética Médica (SGM), Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre 90035-903, Brazil.; Instituto Nacional de Ciência e Tecnologia de Genética Médica Populacional (INAGEMP), Porto Alegre 90035-004, Brazil.; Laboratório de Medicina Genômica (LMG), Centro de Pesquisa Experimental (CPE), Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre 90035-903, Brazil.; Programa de Pós-Graduação em Ciências Médicas, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 91501-970, Brazil.
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Źródło :
Viruses [Viruses] 2021 Feb 20; Vol. 13 (2). Date of Electronic Publication: 2021 Feb 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Microcephaly/*genetics
Nitric Oxide Synthase Type II/*genetics
Tumor Necrosis Factor-alpha/*genetics
Zika Virus/*physiology
Zika Virus Infection/*genetics
Adult ; Alleles ; Brazil ; Case-Control Studies ; Female ; Genetic Predisposition to Disease ; Genetic Variation ; Humans ; Infant ; Male ; Microcephaly/metabolism ; Microcephaly/virology ; Nitric Oxide Synthase Type II/metabolism ; Polymorphism, Genetic ; Pregnancy ; Pregnancy Complications, Infectious/genetics ; Pregnancy Complications, Infectious/metabolism ; Pregnancy Complications, Infectious/virology ; Pregnancy Trimester, First ; Tumor Necrosis Factor-alpha/metabolism ; Young Adult ; Zika Virus/genetics ; Zika Virus Infection/congenital ; Zika Virus Infection/metabolism ; Zika Virus Infection/virology
Czasopismo naukowe
Tytuł :
IL-27 Negatively Regulates Tip-DC Development during Infection.
Autorzy :
Liu G; Division of Immunology, Virginia-Maryland College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA.; Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA.
Abas O; Division of Immunology, Virginia-Maryland College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA.; Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA.
Fu Y; Division of Immunology, Virginia-Maryland College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA.; Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA.
Chen Y; Division of Immunology, Virginia-Maryland College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA.; Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA.
Strickland AB; Division of Immunology, Virginia-Maryland College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA.; Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA.
Sun D; Division of Immunology, Virginia-Maryland College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA.; Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA.
Shi M; Division of Immunology, Virginia-Maryland College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA .; Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA.
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Źródło :
MBio [mBio] 2021 Feb 16; Vol. 12 (1). Date of Electronic Publication: 2021 Feb 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gene Expression Regulation*
Cell Differentiation/*immunology
Dendritic Cells/*physiology
Interleukins/*genetics
Nitric Oxide Synthase Type II/*immunology
Receptors, Interleukin/*genetics
Trypanosoma congolense/*immunology
Tumor Necrosis Factor-alpha/*immunology
Animals ; CD4-Positive T-Lymphocytes/immunology ; Dendritic Cells/immunology ; Interferon-gamma/genetics ; Interferon-gamma/immunology ; Interferon-gamma/metabolism ; Interleukins/immunology ; Lymphocyte Activation ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Monocytes/immunology ; Monocytes/physiology ; Nitric Oxide Synthase Type II/biosynthesis ; Receptors, Interleukin/immunology ; Signal Transduction/immunology ; Trypanosoma brucei brucei/immunology ; Tumor Necrosis Factor-alpha/biosynthesis
Czasopismo naukowe
Tytuł :
Expression Pattern of iNOS, BCL-2 and MMP-9 in the Hip Synovium Tissue of Patients with Osteoarthritis.
Autorzy :
Caric D; Department of Orthopaedics and Traumatology, University Hospital in Split, Spinciceva 1, 21000 Split, Croatia.
Zekic Tomas S; Department of Pathology, Forensic Medicine and Cytology, University Hospital in Split, Spinciceva 1, 21000 Split, Croatia.
Filipovic N; Department of Anatomy, Histology and Embryology, School of Medicine, University of Split, Soltanska 2, 21000 Split, Croatia.
Soljic V; Department of Histology and Embryology, School of Medicine, University of Mostar, Kralja Petra Kresimira IV, 88000 Mostar, Bosnia and Herzegovina.
Benzon B; Department of Anatomy, Histology and Embryology, School of Medicine, University of Split, Soltanska 2, 21000 Split, Croatia.
Glumac S; Department of Anesthesiology and Intensive Care, University Hospital in Split, Spinciceva 1, 21000 Split, Croatia.
Rakovac I; Department of Natural and Health Sciences, Juraj Dobrila University of Pula, Pula, Zagrebačka ul. 30, 52100 Pula, Croatia.
Vukojevic K; Department of Anatomy, Histology and Embryology, School of Medicine, University of Split, Soltanska 2, 21000 Split, Croatia.; Department of Histology and Embryology, School of Medicine, University of Mostar, Kralja Petra Kresimira IV, 88000 Mostar, Bosnia and Herzegovina.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 02; Vol. 22 (3). Date of Electronic Publication: 2021 Feb 02.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation*
Matrix Metalloproteinase 9/*biosynthesis
Nitric Oxide Synthase Type II/*biosynthesis
Osteoarthritis, Hip/*metabolism
Proto-Oncogene Proteins c-bcl-2/*biosynthesis
Synovial Membrane/*metabolism
Aged ; Cross-Sectional Studies ; Female ; Genes, bcl-2 ; Humans ; Male ; Matrix Metalloproteinase 9/genetics ; Middle Aged ; Nitric Oxide Synthase Type II/genetics ; Vascular Endothelial Growth Factor Receptor-1/analysis
Czasopismo naukowe
Tytuł :
Functional role of iNOS-Rac2 interaction in neutrophil extracellular traps (NETs) induced cytotoxicity in sepsis.
Autorzy :
Kumar S; Amity Institute of Biotechnology, Amity University Rajasthan, Amity Education Valley, Kant Kalwar, NH-11C, Jaipur-Delhi Highway, Jaipur, India.
Gupta E; Amity Institute of Biotechnology, Amity University Rajasthan, Amity Education Valley, Kant Kalwar, NH-11C, Jaipur-Delhi Highway, Jaipur, India.
Gupta N; Department of Biotechnology, IIS (deemed to be University), Gurukul Marg, SFS, Mansarovar, Jaipur, India.
Kaushik S; Amity Institute of Biotechnology, Amity University Rajasthan, Amity Education Valley, Kant Kalwar, NH-11C, Jaipur-Delhi Highway, Jaipur, India.
Srivastava VK; Amity Institute of Biotechnology, Amity University Rajasthan, Amity Education Valley, Kant Kalwar, NH-11C, Jaipur-Delhi Highway, Jaipur, India.
Kumar S; Amity School of Architecture and Planning, Amity University Rajasthan, Amity Education Valley, Kant Kalwar, NH-11C, Jaipur-Delhi Highway, Jaipur, India.
Mehta S; Department of Medicine, SMS Medical College & Attached Hospitals, J.L.N. Marg, Jaipur, Rajasthan, India.
Jyoti A; Amity Institute of Biotechnology, Amity University Rajasthan, Amity Education Valley, Kant Kalwar, NH-11C, Jaipur-Delhi Highway, Jaipur, India. Electronic address: .
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Źródło :
Clinica chimica acta; international journal of clinical chemistry [Clin Chim Acta] 2021 Feb; Vol. 513, pp. 43-49. Date of Electronic Publication: 2020 Dec 10.
Typ publikacji :
Journal Article
MeSH Terms :
Extracellular Traps*/metabolism
Nitric Oxide Synthase Type II*/metabolism
Sepsis*
rac GTP-Binding Proteins/*metabolism
Humans ; Neutrophils/metabolism ; Reactive Nitrogen Species/metabolism
Czasopismo naukowe
Tytuł :
Cudratricusxanthone A Inhibits Lipid Accumulation and Expression of Inducible Nitric Oxide Synthase in 3T3-L1 Preadipocytes.
Autorzy :
Kwon HS; Department of Molecular Medicine, College of Medicine, Keimyung University, Daegu 42601, Korea.
Jeong GS; College of Pharmacy, Keimyung University, Daegu 42601, Korea.
Jang BC; Department of Molecular Medicine, College of Medicine, Keimyung University, Daegu 42601, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jan 06; Vol. 22 (2). Date of Electronic Publication: 2021 Jan 06.
Typ publikacji :
Journal Article
MeSH Terms :
Adipocytes/*drug effects
Cell Differentiation/*drug effects
Gene Expression Regulation, Enzymologic/*drug effects
Lipid Metabolism/*drug effects
Nitric Oxide Synthase Type II/*genetics
Xanthones/*pharmacology
3T3-L1 Cells ; Adipocytes/cytology ; Adipocytes/metabolism ; Adipogenesis/drug effects ; Adipogenesis/genetics ; Animals ; Blotting, Western ; CCAAT-Enhancer-Binding Protein-alpha/genetics ; CCAAT-Enhancer-Binding Protein-alpha/metabolism ; Cell Differentiation/genetics ; Fatty Acid Synthases/genetics ; Fatty Acid Synthases/metabolism ; Mice ; Nitric Oxide Synthase Type II/metabolism ; PPAR gamma/genetics ; PPAR gamma/metabolism ; Phosphorylation/drug effects ; Reverse Transcriptase Polymerase Chain Reaction
Czasopismo naukowe
Tytuł :
Proxeed plus salvage rat testis from ischemia- reperfused injury by enhancing antioxidant's activities and inhibition of iNOS expression.
Autorzy :
Sangodele JO; Department of Biochemistry, Bingham University, Abuja-Keffi Expressway Road, P.M.B 005, Karu, Nigeria. Electronic address: .
Inuwa Z; Department of Biochemistry, Bingham University, Abuja-Keffi Expressway Road, P.M.B 005, Karu, Nigeria. Electronic address: .
Lawal B; Graduate Institute for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taiwan. Electronic address: .
Adebayo-Gege G; Department of Human Physiology, Faculty of Basic Medical Sciences, Baze University, Abuja, Nigeria. Electronic address: .
Okoli BJ; Institute of Chemical and Biotechnology, Vaal University of Technology, Science Park, Private Bag x021, South Africa; Department of Chemical Sciences, Faculty of Science and Technology, Bingham University Karu, Nigeria. Electronic address: .
Mtunzi F; Institute of Chemical and Biotechnology, Vaal University of Technology, Science Park, Private Bag x021, South Africa. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Jan; Vol. 133, pp. 111086. Date of Electronic Publication: 2020 Dec 11.
Typ publikacji :
Journal Article
MeSH Terms :
Dietary Supplements*
Antioxidants/*pharmacology
Enzyme Inhibitors/*pharmacology
Nitric Oxide Synthase Type II/*antagonists & inhibitors
Oxidative Stress/*drug effects
Reperfusion Injury/*prevention & control
Spermatic Cord Torsion/*drug therapy
Testis/*drug effects
Animals ; Apoptosis/drug effects ; Biomarkers/blood ; Disease Models, Animal ; Male ; Nitric Oxide Synthase Type II/metabolism ; Rats ; Rats, Wistar ; Reperfusion Injury/enzymology ; Reperfusion Injury/pathology ; Signal Transduction ; Spermatic Cord Torsion/enzymology ; Spermatic Cord Torsion/pathology ; Spermatogenesis/drug effects ; Testis/enzymology ; Testis/pathology
Czasopismo naukowe
Tytuł :
Inhibition of mitochondrial fission and iNOS in the dorsal vagal complex protects from overeating and weight gain.
Autorzy :
Patel B; School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, United Kingdom.
New LE; School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, United Kingdom.
Griffiths JC; School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, United Kingdom.
Deuchars J; School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, United Kingdom.
Filippi BM; School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, United Kingdom. Electronic address: .
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Źródło :
Molecular metabolism [Mol Metab] 2021 Jan; Vol. 43, pp. 101123. Date of Electronic Publication: 2020 Nov 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dynamins/*metabolism
Mitochondrial Dynamics/*physiology
Nitric Oxide Synthase Type II/*physiology
Animals ; Body Weight/physiology ; Diet, High-Fat ; Dynamins/physiology ; Feeding Behavior/physiology ; Glucose/metabolism ; Hyperphagia/metabolism ; Hyperphagia/prevention & control ; Insulin/metabolism ; Insulin Resistance/physiology ; Male ; Nitric Oxide Synthase Type II/metabolism ; Obesity/metabolism ; Obesity/prevention & control ; Rats ; Rats, Sprague-Dawley ; Vagus Nerve/drug effects ; Weight Gain
Czasopismo naukowe
Tytuł :
Comparative Inhibitory Efficacy on the iNOS/NO System of Curcuminand Tetrahydrocurcumin-Self-Microemulsifying Liquid Formulation in Chronic Gastric Ulcer Model.
Autorzy :
Mahattanadul S; Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.
Kongpuckdee S; Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.
Wiwattanapatapee R; Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla, Thailand.
Tansakul P; Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla, Thailand.
Nitiruangjaras A; Department of Pathology, Faculty of Medicine, Prince of Songkla University, Hat-Yai, Songkhla, Thailand.
Hansakul P; Department of Preclinical Sciences, Faculty of Medicine, Thammasat University, Ransit Campus, Klongluang, Pathumthani, Thailand.
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Źródło :
Current pharmaceutical biotechnology [Curr Pharm Biotechnol] 2021; Vol. 22 (7), pp. 1005-1012.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Curcumin/*analogs & derivatives
Curcumin/*therapeutic use
Emulsifying Agents/*therapeutic use
Nitric Oxide/*antagonists & inhibitors
Nitric Oxide Synthase Type II/*antagonists & inhibitors
Stomach Ulcer/*drug therapy
Administration, Oral ; Animals ; Curcumin/pharmacology ; Drug Compounding/methods ; Emulsifying Agents/pharmacology ; Macrophages/drug effects ; Macrophages/metabolism ; Male ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type II/metabolism ; Rats ; Rats, Wistar ; Stomach Ulcer/chemically induced ; Stomach Ulcer/metabolism
Czasopismo naukowe

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