Temat: "Nitric oxide synthase" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Pentoxifylline as a therapeutic option for pre-eclampsia: a study on its placental effects.
Autorzy:: Broekhuizen M; Division of Neonatology, Department of Paediatrics, Erasmus MC University Medical Center, Rotterdam, The Netherlands.; Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands.; Division of Experimental Cardiology, Department of Cardiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
de Vries R; Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Smits MAW; Laboratory Medical Immunology, Department of Immunology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Dik WA; Laboratory Medical Immunology, Department of Immunology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Schoenmakers S; Department of Obstetrics and Gynaecology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Koch BCP; Department of Pharmacy, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Merkus D; Division of Experimental Cardiology, Department of Cardiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Reiss IKM; Division of Neonatology, Department of Paediatrics, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Danser AHJ; Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Simons SHP; Division of Neonatology, Department of Paediatrics, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Hitzerd E; Division of Neonatology, Department of Paediatrics, Erasmus MC University Medical Center, Rotterdam, The Netherlands.; Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands.; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2022 Nov; Vol. 179 (22), pp. 5074-5088. Date of Electronic Publication: 2022 Aug 05.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Pentoxifylline*/metabolism
Pentoxifylline*/pharmacology
Pentoxifylline*/therapeutic use
Pre-Eclampsia*/drug therapy
Adenosine/pharmacology ; Anti-Inflammatory Agents/pharmacology ; Cyclic GMP/metabolism ; Female ; Humans ; Nitric Oxide Synthase/metabolism ; Phosphodiesterase Inhibitors/pharmacology ; Phosphodiesterase Inhibitors/therapeutic use ; Placenta/metabolism ; Pregnancy ; Purinergic P1 Receptor Antagonists/metabolism ; Purinergic P1 Receptor Antagonists/pharmacology ; Purinergic P1 Receptor Antagonists/therapeutic use ; Vasodilator Agents/pharmacology

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Skocz do pozycji: 2.

Tytuł:: Dual inhibition of cannabinoid CB 1 receptor and inducible NOS attenuates obesity-induced chronic kidney disease.
Autorzy:: Udi S; Obesity and Metabolism Laboratory, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Hinden L; Obesity and Metabolism Laboratory, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Ahmad M; Obesity and Metabolism Laboratory, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Drori A; Obesity and Metabolism Laboratory, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Iyer MR; Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
Cinar R; Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
Herman-Edelstein M; Department of Nephrology & Hypertension, Rabin Medical Center, Petah Tikva, Israel.; Sackler Medical School, Tel Aviv University, Tel Aviv, Israel.
Tam J; Obesity and Metabolism Laboratory, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2020 Jan; Vol. 177 (1), pp. 110-127. Date of Electronic Publication: 2019 Dec 27.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Diet, High-Fat/*adverse effects
Nitric Oxide Synthase Type II/*antagonists & inhibitors
Obesity/*prevention & control
Receptor, Cannabinoid, CB1/*antagonists & inhibitors
Renal Insufficiency, Chronic/*prevention & control
Animals ; Cannabinoid Receptor Antagonists/pharmacology ; Cannabinoid Receptor Antagonists/therapeutic use ; Cell Line, Transformed ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Nitric Oxide Synthase Type II/metabolism ; Obesity/etiology ; Obesity/metabolism ; Receptor, Cannabinoid, CB1/metabolism ; Renal Insufficiency, Chronic/etiology ; Renal Insufficiency, Chronic/metabolism

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Skocz do pozycji: 3.

Tytuł:: Aucubin protects against pressure overload-induced cardiac remodelling via the β 3 -adrenoceptor-neuronal NOS cascades.
Autorzy:: Wu QQ; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.; Cardiovascular Research Institute, Wuhan University, Wuhan, China.; Hubei Key Laboratory of Cardiology, Wuhan, China.
Xiao Y; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.; Cardiovascular Research Institute, Wuhan University, Wuhan, China.; Hubei Key Laboratory of Cardiology, Wuhan, China.
Duan MX; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.; Cardiovascular Research Institute, Wuhan University, Wuhan, China.; Hubei Key Laboratory of Cardiology, Wuhan, China.
Yuan Y; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.; Cardiovascular Research Institute, Wuhan University, Wuhan, China.; Hubei Key Laboratory of Cardiology, Wuhan, China.
Jiang XH; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.; Cardiovascular Research Institute, Wuhan University, Wuhan, China.; Hubei Key Laboratory of Cardiology, Wuhan, China.
Yang Z; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.; Cardiovascular Research Institute, Wuhan University, Wuhan, China.; Hubei Key Laboratory of Cardiology, Wuhan, China.
Liao HH; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.; Cardiovascular Research Institute, Wuhan University, Wuhan, China.; Hubei Key Laboratory of Cardiology, Wuhan, China.
Deng W; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.; Cardiovascular Research Institute, Wuhan University, Wuhan, China.; Hubei Key Laboratory of Cardiology, Wuhan, China.
Tang QZ; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.; Cardiovascular Research Institute, Wuhan University, Wuhan, China.; Hubei Key Laboratory of Cardiology, Wuhan, China.; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2018 May; Vol. 175 (9), pp. 1548-1566. Date of Electronic Publication: 2018 Mar 25.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Heart Failure/*prevention & control
Iridoid Glucosides/*pharmacology
Nitric Oxide Synthase Type I/*metabolism
Receptors, Adrenergic, beta-3/*metabolism
Ventricular Remodeling/*drug effects
Adrenergic beta-3 Receptor Agonists/pharmacology ; Adrenergic beta-3 Receptor Antagonists/pharmacology ; Animals ; Cardiotonic Agents/pharmacology ; Cardiotonic Agents/therapeutic use ; Cells, Cultured ; Cyclic AMP/metabolism ; Dose-Response Relationship, Drug ; Drug Interactions ; Hypertrophy/drug therapy ; Hypertrophy/pathology ; Iridoid Glucosides/therapeutic use ; Male ; Mice ; Mice, Knockout ; Myocardium/pathology ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Nitric Oxide Synthase Type I/biosynthesis ; Nitric Oxide Synthase Type I/genetics ; Oxidative Stress/drug effects ; Phenylephrine/pharmacology ; Protective Agents/pharmacology ; Rats ; Receptors, Adrenergic, beta-3/genetics

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Skocz do pozycji: 4.

Tytuł:: Endothelial TRPV4-eNOS coupling as a vital therapy target for treatment of hypertension.
Autorzy:: Mao A; Wuxi School of Medicine, Jiangnan University, Wuxi, China.
Zhang P; Wuxi School of Medicine, Jiangnan University, Wuxi, China.
Zhang K; Wuxi School of Medicine, Jiangnan University, Wuxi, China.
Kan H; Wuxi School of Medicine, Jiangnan University, Wuxi, China.
He D; Wuxi School of Medicine, Jiangnan University, Wuxi, China.
Han X; Wuxi School of Medicine, Jiangnan University, Wuxi, China.
Wang Z; Wuxi School of Medicine, Jiangnan University, Wuxi, China.
Tang C; School of Pharmaceutical Sciences, Jiangnan University, Wuxi, China.
Ma X; Wuxi School of Medicine, Jiangnan University, Wuxi, China.; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2022 May; Vol. 179 (10), pp. 2297-2312. Date of Electronic Publication: 2022 Jan 28.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Hypertension*/metabolism
Transient Receptor Potential Channels*/metabolism
Nitric Oxide Synthase Type III/*metabolism
Animals ; Antihypertensive Agents/pharmacology ; Endothelial Cells ; Endothelium, Vascular ; Mesenteric Arteries ; Mice ; Molecular Docking Simulation ; TRPV Cation Channels/metabolism ; Vasodilation

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Skocz do pozycji: 5.

Tytuł:: Stimulation of brain nicotinic acetylcholine receptors activates adrenomedullary outflow via brain inducible NO synthase-mediated S-nitrosylation.
Autorzy:: Higashi Y; Department of Pharmacology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
Shimizu T; Department of Pharmacology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
Yamamoto M; Department of Pharmacology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
Tanaka K; Department of Neurobiology and Anatomy, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
Yawata T; Department of Neurosurgery, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
Shimizu S; Department of Pharmacology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
Zou S; Department of Pharmacology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
Ueba T; Department of Neurosurgery, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
Yuri K; Department of Neurobiology and Anatomy, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
Saito M; Department of Pharmacology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2018 Oct; Vol. 175 (19), pp. 3758-3772. Date of Electronic Publication: 2018 Aug 12.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Adrenal Medulla/*drug effects
Brain/*drug effects
Bridged Bicyclo Compounds, Heterocyclic/*pharmacology
Nitric Oxide/*antagonists & inhibitors
Nitric Oxide Synthase Type II/*antagonists & inhibitors
Pyridines/*pharmacology
Receptors, Nicotinic/*metabolism
Adrenal Medulla/metabolism ; Animals ; Brain/metabolism ; Bridged Bicyclo Compounds, Heterocyclic/administration & dosage ; Catecholamines/blood ; Catecholamines/metabolism ; Infusions, Intraventricular ; Male ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type II/metabolism ; Pyridines/administration & dosage ; Rats ; Rats, Wistar

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Skocz do pozycji: 6.

Tytuł:: A novel inhibitor of inducible NOS dimerization protects against cytokine-induced rat beta cell dysfunction.
Autorzy:: Zhong L; California Institute for Biomedical Research (Calibr), La Jolla, CA, 92037, USA.
Tran T; California Institute for Biomedical Research (Calibr), La Jolla, CA, 92037, USA.
Baguley TD; California Institute for Biomedical Research (Calibr), La Jolla, CA, 92037, USA.
Lee SJ; California Institute for Biomedical Research (Calibr), La Jolla, CA, 92037, USA.
Henke A; California Institute for Biomedical Research (Calibr), La Jolla, CA, 92037, USA.
To A; California Institute for Biomedical Research (Calibr), La Jolla, CA, 92037, USA.
Li S; California Institute for Biomedical Research (Calibr), La Jolla, CA, 92037, USA.
Yu S; California Institute for Biomedical Research (Calibr), La Jolla, CA, 92037, USA.
Grieco FA; ULB Center for Diabetes Research, Universite´ Libre de Bruxelles (ULB), Brussels, 1070, Belgium.
Roland J; California Institute for Biomedical Research (Calibr), La Jolla, CA, 92037, USA.
Schultz PG; California Institute for Biomedical Research (Calibr), La Jolla, CA, 92037, USA.; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Eizirik DL; ULB Center for Diabetes Research, Universite´ Libre de Bruxelles (ULB), Brussels, 1070, Belgium.
Rogers N; California Institute for Biomedical Research (Calibr), La Jolla, CA, 92037, USA.
Chartterjee AK; California Institute for Biomedical Research (Calibr), La Jolla, CA, 92037, USA.
Tremblay MS; California Institute for Biomedical Research (Calibr), La Jolla, CA, 92037, USA.
Shen W; California Institute for Biomedical Research (Calibr), La Jolla, CA, 92037, USA.; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2018 Sep; Vol. 175 (17), pp. 3470-3485. Date of Electronic Publication: 2018 Jul 14.
Typ publikacji:: Journal Article
MeSH Terms:: Insulin-Secreting Cells/*drug effects
Interferon-gamma/*pharmacology
Interleukin-1beta/*pharmacology
Nitric Oxide Synthase Type II/*antagonists & inhibitors
Animals ; Caspase 9/metabolism ; Cell Line ; Cell Survival/drug effects ; Cytochromes c/metabolism ; Dimerization ; Enzyme Activation ; Glucose/pharmacology ; Insulin-Secreting Cells/cytology ; Nitric Oxide Synthase Type II/chemistry ; Rats ; Signal Transduction

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Skocz do pozycji: 7.

Tytuł:: Heat shock protein-27 and sex-selective regulation of muscarinic and proteinase-activated receptor 2-mediated vasodilatation: differential sensitivity to endothelial NOS inhibition.
Autorzy:: Pulakazhi Venu VK; Department of Physiology and Pharmacology, Inflammation Research Network-Snyder Institute for Chronic Disease, University of Calgary Cumming School of Medicine, Calgary, AB, Canada.; Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary Cumming School of Medicine, Calgary, AB, Canada.
Saifeddine M; Department of Physiology and Pharmacology, Inflammation Research Network-Snyder Institute for Chronic Disease, University of Calgary Cumming School of Medicine, Calgary, AB, Canada.
Mihara K; Department of Physiology and Pharmacology, Inflammation Research Network-Snyder Institute for Chronic Disease, University of Calgary Cumming School of Medicine, Calgary, AB, Canada.
El-Daly M; Department of Physiology and Pharmacology, Inflammation Research Network-Snyder Institute for Chronic Disease, University of Calgary Cumming School of Medicine, Calgary, AB, Canada.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, El-Minia, Egypt.
Belke D; Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary Cumming School of Medicine, Calgary, AB, Canada.
Dean JLE; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
O'Brien ER; Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary Cumming School of Medicine, Calgary, AB, Canada.
Hirota SA; Department of Physiology and Pharmacology, Inflammation Research Network-Snyder Institute for Chronic Disease, University of Calgary Cumming School of Medicine, Calgary, AB, Canada.
Hollenberg MD; Department of Physiology and Pharmacology, Inflammation Research Network-Snyder Institute for Chronic Disease, University of Calgary Cumming School of Medicine, Calgary, AB, Canada.; Department of Medicine, University of Calgary Cumming School of Medicine, Calgary, AB, Canada.; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2018 Jun; Vol. 175 (11), pp. 2063-2076. Date of Electronic Publication: 2018 Apr 25.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Enzyme Inhibitors/*pharmacology
HSP27 Heat-Shock Proteins/*antagonists & inhibitors
Nitric Oxide Synthase Type III/*antagonists & inhibitors
Receptor, PAR-2/*antagonists & inhibitors
Receptors, Muscarinic/*metabolism
Vasodilation/*drug effects
Animals ; Dose-Response Relationship, Drug ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/enzymology ; Enzyme Inhibitors/chemistry ; Female ; HSP27 Heat-Shock Proteins/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; NG-Nitroarginine Methyl Ester/chemistry ; NG-Nitroarginine Methyl Ester/pharmacology ; Nitric Oxide Synthase Type III/metabolism ; Oxadiazoles/chemistry ; Oxadiazoles/pharmacology ; Quinoxalines/chemistry ; Quinoxalines/pharmacology ; Receptor, PAR-2/metabolism ; Structure-Activity Relationship

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Skocz do pozycji: 8.

Tytuł:: Nitric oxide (NO) synthase but not NO, HNO or H 2 O 2 mediates endothelium-dependent relaxation of resistance arteries from patients with cardiovascular disease.
Autorzy:: Matthies M; Department of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Rosenstand K; Department of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Nissen I; Department of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Muitjens S; Department of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Riber LP; Department of Cardiac, Thoracic and Vascular Surgery, Odense University Hospital, Odense, Denmark.
De Mey JGR; Department of Molecular Medicine, University of Southern Denmark, Odense, Denmark.; Department of Pharmacology and Personalized Medicine, Maastricht University, Maastricht, The Netherlands.
Bloksgaard M; Department of Molecular Medicine, University of Southern Denmark, Odense, Denmark.; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2022 Mar; Vol. 179 (5), pp. 1049-1064. Date of Electronic Publication: 2021 Nov 16.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cardiovascular Diseases*
Nitric Oxide*/metabolism
Arteries/metabolism ; Bradykinin/pharmacology ; Catalase ; Endothelium, Vascular/metabolism ; Humans ; Nitric Oxide Synthase ; Soluble Guanylyl Cyclase ; Vasodilation

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Skocz do pozycji: 9.

Tytuł:: Decreased production of neuronal NOS-derived hydrogen peroxide contributes to endothelial dysfunction in atherosclerosis.
Autorzy:: Capettini LS; Department of Physiology and Biophysics, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Cortes SF
Silva JF
Alvarez-Leite JI
Lemos VS; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2011 Nov; Vol. 164 (6), pp. 1738-48.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Atherosclerosis/*physiopathology
Endothelium, Vascular/*physiopathology
Hydrogen Peroxide/*metabolism
Nitric Oxide Synthase Type I/*physiology
Acetylcholine/pharmacology ; Animals ; Aorta, Thoracic/drug effects ; Aorta, Thoracic/physiopathology ; Apolipoproteins E/deficiency ; Apolipoproteins E/genetics ; Atherosclerosis/metabolism ; Catalase/pharmacology ; Disease Models, Animal ; Endothelium, Vascular/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Nitric Oxide Synthase Type I/deficiency ; Nitric Oxide Synthase Type I/genetics ; Nitric Oxide Synthase Type III/deficiency ; Nitric Oxide Synthase Type III/genetics ; Nitric Oxide Synthase Type III/physiology ; Vasodilation/drug effects

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Skocz do pozycji: 10.

Tytuł:: Central nicotinic acetylcholine receptor involved in Ca(2+) -calmodulin-endothelial nitric oxide synthase pathway modulated hypotensive effects.
Autorzy:: Cheng PW; Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
Lu PJ
Chen SR
Ho WY
Cheng WH
Hong LZ
Yeh TC
Sun GC
Wang LL
Hsiao M
Tseng CJ; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2011 Jul; Vol. 163 (6), pp. 1203-13.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Calcium Signaling/*physiology
Calmodulin/*metabolism
Hypotension/*chemically induced
Nitric Oxide Synthase Type III/*metabolism
Receptors, Nicotinic/*metabolism
Animals ; Calcium/metabolism ; Calmodulin/antagonists & inhibitors ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/physiology ; Male ; Nicotine/pharmacology ; Nitric Oxide/biosynthesis ; Nitric Oxide Synthase Type I/genetics ; Nitric Oxide Synthase Type I/metabolism ; Nitric Oxide Synthase Type III/antagonists & inhibitors ; Rats ; Rats, Inbred WKY ; Solitary Nucleus/drug effects ; Solitary Nucleus/physiology

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Skocz do pozycji: 11.

Tytuł:: Does endothelial tetrahydrobiopterin control the endothelial NO synthase coupling state in arterial resistance arteries?
Autorzy:: Münzel T; Center for Cardiology, Cardiology I, University Medical Center Mainz, Mainz, Germany.
Daiber A; Center for Cardiology, Cardiology I, University Medical Center Mainz, Mainz, Germany.; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2017 Jul; Vol. 174 (14), pp. 2422-2424. Date of Electronic Publication: 2017 Jun 04.
Typ publikacji:: Journal Article
MeSH Terms:: Arteries/*drug effects
Biopterins/*analogs & derivatives
Cardiovascular Diseases/*drug therapy
Nitric Oxide Synthase Type III/*antagonists & inhibitors
Animals ; Arteries/metabolism ; Biopterins/pharmacology ; Cardiovascular Diseases/metabolism ; Humans ; Mice ; Nitric Oxide Synthase Type III/metabolism

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Skocz do pozycji: 12.

Tytuł:: Lack of critical involvement of endothelial nitric oxide synthase in vascular nitrate tolerance in mice.
Autorzy:: Wang EQ; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, NY 14260-1200, USA.
Lee WI
Fung HL; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2002 Jan; Vol. 135 (2), pp. 299-302.
Typ publikacji:: Comparative Study; Journal Article
MeSH Terms:: Vasodilation*/*drug effects
Vasodilation*/genetics
Nitrates/*pharmacology
Nitric Oxide Synthase/*biosynthesis
Nitric Oxide Synthase/*genetics
Animals ; Aorta, Thoracic/drug effects ; Aorta, Thoracic/enzymology ; Cyclic GMP/metabolism ; Dose-Response Relationship, Drug ; Drug Tolerance/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Nitric Oxide Synthase/deficiency ; Nitric Oxide Synthase Type II ; Nitric Oxide Synthase Type III ; Nitroglycerin/pharmacology ; Vasodilator Agents/pharmacology

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Skocz do pozycji: 13.

Tytuł:: The role of nitric oxide synthase in reduced vasocontractile responsiveness induced by prolonged alpha1-adrenergic receptor stimulation in rat thoracic aorta.
Autorzy:: Gürdal H; Department of Pharmacology and Clinical Pharmacology, Ankara University School of Medicine, Sihhiye, Ankara 06100, Turkey. />Can A
Uğur M; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2005 May; Vol. 145 (2), pp. 203-10.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Adrenergic alpha-1 Receptor Agonists*
Aorta, Thoracic/*drug effects
Nitric Oxide Synthase/*metabolism
Vasoconstriction/*drug effects
Animals ; Aorta, Thoracic/physiology ; In Vitro Techniques ; Male ; Muscle Contraction/drug effects ; Muscle, Smooth, Vascular/drug effects ; Muscle, Smooth, Vascular/physiology ; Nitric Oxide Synthase Type II ; Nitric Oxide Synthase Type III ; Phenylephrine/pharmacology ; RNA, Messenger/metabolism ; Rats ; Rats, Wistar ; Time Factors

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Skocz do pozycji: 14.

Tytuł:: Gender-specific vascular effects elicited by chronic ethanol consumption in rats: a role for inducible nitric oxide synthase.
Autorzy:: Tirapelli CR; Department of Psychiatry Nursing and Human Sciences, College of Nursing of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Fukada SY
Yogi A
Chignalia AZ
Tostes RC
Bonaventura D
Lanchote VL
Cunha FQ
de Oliveira AM; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2008 Feb; Vol. 153 (3), pp. 468-79. Date of Electronic Publication: 2007 Nov 26.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Central Nervous System Depressants/*pharmacology
Endothelium, Vascular/*drug effects
Ethanol/*pharmacology
Nitric Oxide Synthase Type II/*drug effects
Up-Regulation/*drug effects
Animals ; Aorta, Thoracic/metabolism ; Endothelium, Vascular/metabolism ; Female ; In Vitro Techniques ; Male ; Nitric Oxide Synthase Type II/metabolism ; Nitric Oxide Synthase Type III/drug effects ; Nitric Oxide Synthase Type III/metabolism ; Ovariectomy ; RNA, Messenger/drug effects ; RNA, Messenger/metabolism ; Rats ; Rats, Wistar ; Sex Factors ; Vasoconstriction/drug effects ; Vasodilation/drug effects

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Skocz do pozycji: 15.

Tytuł:: Mechanisms involved in the regulation of mRNA for M2 muscarinic acetylcholine receptors and endothelial and neuronal NO synthases in rat atria.
Autorzy:: Ganzinelli S; Department of Pharmacology, School of Dentistry, University of Buenos Aires and Argentine National Research Council, Buenos Aires, Argentina.
Joensen L
Borda E
Bernabeo G
Sterin-Borda L; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2007 May; Vol. 151 (2), pp. 175-85. Date of Electronic Publication: 2007 Mar 26.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Myocardium/*metabolism
Nitric Oxide Synthase Type III/*genetics
RNA, Messenger/*genetics
Receptor, Muscarinic M2/*genetics
Animals ; Carbachol/pharmacology ; Cholinergic Agonists/pharmacology ; Dose-Response Relationship, Drug ; Estrenes/pharmacology ; Gene Expression Regulation/drug effects ; Heart/drug effects ; Heart/physiology ; Heart Atria ; In Vitro Techniques ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Naphthalenes/pharmacology ; Nitric Oxide Synthase Type I/antagonists & inhibitors ; Nitric Oxide Synthase Type I/genetics ; Nitric Oxide Synthase Type I/metabolism ; Nitric Oxide Synthase Type III/antagonists & inhibitors ; Nitric Oxide Synthase Type III/metabolism ; Phosphatidylinositols/metabolism ; Pyrrolidinones/pharmacology ; RNA, Messenger/metabolism ; Rats ; Rats, Wistar ; Receptor, Muscarinic M2/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Trifluoperazine/pharmacology ; Type C Phospholipases/antagonists & inhibitors ; omega-N-Methylarginine/pharmacology

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 16.

Tytuł:: Endothelial dysfunction and compromised eNOS/Akt signaling in the thoracic aorta during the progression of Marfan syndrome.
Autorzy:: Chung AW; Child and Family Research Institute and Departments of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada. />Au Yeung K
Cortes SF
Sandor GG
Judge DP
Dietz HC
van Breemen C; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2007 Apr; Vol. 150 (8), pp. 1075-83. Date of Electronic Publication: 2007 Mar 05.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Signal Transduction*/drug effects
Vasodilation*/drug effects
Aorta, Thoracic/*metabolism
Endothelium, Vascular/*metabolism
Marfan Syndrome/*metabolism
Microfilament Proteins/*metabolism
Nitric Oxide Synthase Type II/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Acetylcholine/pharmacology ; Age Factors ; Animals ; Aorta, Abdominal/metabolism ; Aorta, Abdominal/physiopathology ; Aorta, Thoracic/drug effects ; Aorta, Thoracic/physiopathology ; Calcium/metabolism ; Cyclic GMP/metabolism ; Disease Models, Animal ; Disease Progression ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/physiopathology ; Enzyme Inhibitors/pharmacology ; Fibrillin-1 ; Fibrillins ; Marfan Syndrome/physiopathology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Microfilament Proteins/genetics ; NG-Nitroarginine Methyl Ester/pharmacology ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type II/antagonists & inhibitors ; Nitric Oxide Synthase Type III ; Phosphorylation ; Vasodilator Agents/pharmacology

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 17.

Tytuł:: Role of inducible nitric oxide synthase in endothelium-independent relaxation to raloxifene in rat aorta.
Autorzy:: Wong CM; Partner State Key Laboratory of Environmental and Biological Analysis and Department of Chemistry, Hong Kong Baptist University (HKBU), Hong Kong.; HKBU Institute for Research and Continuing Education, Shenzhen, China.; School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong.
Au CL; School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong.
Tsang SY; School of Life Sciences and State Key Laboratory of Agrobiotechnology, Chinese University of Hong Kong, Hong Kong.
Lau CW; School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong.
Yao X; School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong.
Cai Z; Partner State Key Laboratory of Environmental and Biological Analysis and Department of Chemistry, Hong Kong Baptist University (HKBU), Hong Kong.; HKBU Institute for Research and Continuing Education, Shenzhen, China.
Chung AC; Partner State Key Laboratory of Environmental and Biological Analysis and Department of Chemistry, Hong Kong Baptist University (HKBU), Hong Kong.; HKBU Institute for Research and Continuing Education, Shenzhen, China.; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2017 Apr; Vol. 174 (8), pp. 718-733. Date of Electronic Publication: 2017 Feb 27.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Aorta/*drug effects
Endothelium/*drug effects
Nitric Oxide Synthase Type II/*metabolism
Raloxifene Hydrochloride/*pharmacology
Animals ; Aorta/metabolism ; Calcium/metabolism ; Dose-Response Relationship, Drug ; Endothelium/metabolism ; Male ; Muscle, Smooth/drug effects ; Muscle, Smooth/metabolism ; Nitric Oxide Synthase Type II/biosynthesis ; Nitric Oxide Synthase Type II/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats ; Rats, Sprague-Dawley ; Structure-Activity Relationship