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Wyszukujesz frazę ""Nitrogen Mustard Compounds"" wg kryterium: Temat


Tytuł :
Delta-9 THC can be detected and quantified in the semen of men who are chronic users of inhaled cannabis.
Autorzy :
Lee MS; Brigham and Women's Hospital, Center for Infertility and Reproductive Surgery, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA. .
Lanes A; Brigham and Women's Hospital, Center for Infertility and Reproductive Surgery, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Ginsburg ES; Brigham and Women's Hospital, Center for Infertility and Reproductive Surgery, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Fox JH; Brigham and Women's Hospital, Center for Infertility and Reproductive Surgery, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
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Źródło :
Journal of assisted reproduction and genetics [J Assist Reprod Genet] 2020 Jun; Vol. 37 (6), pp. 1497-1504. Date of Electronic Publication: 2020 Apr 30.
Typ publikacji :
Journal Article
MeSH Terms :
Cannabis/*adverse effects
Dronabinol/*adverse effects
Dronabinol/*analogs & derivatives
Nitrogen Mustard Compounds/*isolation & purification
Semen/*drug effects
Adolescent ; Adult ; Cannabinoids/blood ; Cannabinoids/urine ; Cannabis/metabolism ; Dronabinol/administration & dosage ; Dronabinol/blood ; Dronabinol/isolation & purification ; Gonadal Steroid Hormones/blood ; Humans ; Male ; Middle Aged ; Nitrogen Mustard Compounds/blood ; Prolactin/blood ; Semen/metabolism ; Semen Analysis ; Sperm Count ; Young Adult
Czasopismo naukowe
Tytuł :
Imidazotetrazines as Weighable Diazomethane Surrogates for Esterifications and Cyclopropanations.
Autorzy :
Svec RL; Department of Chemistry and Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Hergenrother PJ; Department of Chemistry and Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
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Źródło :
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2020 Jan 27; Vol. 59 (5), pp. 1857-1862. Date of Electronic Publication: 2019 Dec 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cyclopropanes/*chemistry
Diazomethane/*chemistry
Nitrogen Mustard Compounds/*therapeutic use
Antineoplastic Agents/pharmacology ; Esterification ; Humans ; Models, Molecular ; Nitrogen Mustard Compounds/pharmacology
Czasopismo naukowe
Tytuł :
Bypass of DNA interstrand crosslinks by a Rev1-DNA polymerase ζ complex.
Autorzy :
Bezalel-Buch R; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, Saint Louis, MO, USA.
Cheun YK; Center for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Republic of Korea.
Roy U; Department of Chemistry, Stony Brook University, Stony Book, NY 11794, USA.; Department of Biochemistry & Molecular Biophysics, Columbia University, New York, NY 10032, USA.
Schärer OD; Center for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Republic of Korea.; Department of Biological Sciences, School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea.
Burgers PM; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, Saint Louis, MO, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Sep 04; Vol. 48 (15), pp. 8461-8473.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA/*genetics
DNA-Directed DNA Polymerase/*genetics
Nucleotidyltransferases/*genetics
Saccharomyces cerevisiae Proteins/*genetics
Chromosome Structures/drug effects ; Chromosome Structures/genetics ; DNA Damage/drug effects ; DNA Damage/genetics ; DNA Repair/drug effects ; DNA Repair/genetics ; DNA Replication/genetics ; Multiprotein Complexes/genetics ; Nitrogen Mustard Compounds/pharmacology ; Saccharomyces cerevisiae/genetics
Czasopismo naukowe
Tytuł :
Interactions of newly synthesized platinum nanoparticles with ICR-191 and their potential application.
Autorzy :
Borowik A; University of Gdansk, Intercollegiate Faculty of Biotechnology UG and MUG, Laboratory of Biophysics, Abrahama 58, Gdansk, 80-307, Poland.
Banasiuk R; University of Gdansk, Intercollegiate Faculty of Biotechnology UG and MUG, Laboratory of Biologically Active Compounds, Abrahama 58, Gdansk, 80-307, Poland.
Derewonko N; University of Gdansk, Intercollegiate Faculty of Biotechnology UG and MUG, Laboratory of Virus Molecular Biology, Abrahama 58, Gdansk, 80-307, Poland.
Rychlowski M; University of Gdansk, Intercollegiate Faculty of Biotechnology UG and MUG, Laboratory of Virus Molecular Biology, Abrahama 58, Gdansk, 80-307, Poland.
Krychowiak-Masnicka M; University of Gdansk, Intercollegiate Faculty of Biotechnology UG and MUG, Laboratory of Biologically Active Compounds, Abrahama 58, Gdansk, 80-307, Poland.
Wyrzykowski D; University of Gdansk, Faculty of Chemistry, Wita Stwosza 63, Gdansk, 80-308, Poland.
Ziabka M; AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Ceramics and Refractories, Krakow, 30-059, Poland.
Woziwodzka A; University of Gdansk, Intercollegiate Faculty of Biotechnology UG and MUG, Laboratory of Biophysics, Abrahama 58, Gdansk, 80-307, Poland.
Krolicka A; University of Gdansk, Intercollegiate Faculty of Biotechnology UG and MUG, Laboratory of Biologically Active Compounds, Abrahama 58, Gdansk, 80-307, Poland. .
Piosik J; University of Gdansk, Intercollegiate Faculty of Biotechnology UG and MUG, Laboratory of Biophysics, Abrahama 58, Gdansk, 80-307, Poland. .
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Źródło :
Scientific reports [Sci Rep] 2019 Mar 21; Vol. 9 (1), pp. 4987. Date of Electronic Publication: 2019 Mar 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aminacrine/*analogs & derivatives
Drug Delivery Systems/*adverse effects
Metal Nanoparticles/*chemistry
Nitrogen Mustard Compounds/*chemistry
Platinum/*chemistry
Aminacrine/chemical synthesis ; Aminacrine/chemistry ; Aminacrine/therapeutic use ; Biophysical Phenomena ; Humans ; Metal Nanoparticles/therapeutic use ; Mutagens/chemistry ; Mutagens/therapeutic use ; Mutagens/toxicity ; Nitrogen Mustard Compounds/chemical synthesis ; Nitrogen Mustard Compounds/therapeutic use
Czasopismo naukowe
Tytuł :
Nitrogen Mustards as Alkylating Agents: A Review on Chemistry, Mechanism of Action and Current USFDA Status of Drugs.
Autorzy :
More GS; Department of Pharmaceutical Chemistry, Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Savitribai Phule Pune University, Pune, India.
Thomas AB; Department of Pharmaceutical Chemistry, Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Savitribai Phule Pune University, Pune, India.
Chitlange SS; Department of Pharmaceutical Chemistry, Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Savitribai Phule Pune University, Pune, India.
Nanda RK; Department of Pharmaceutical Chemistry, Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Savitribai Phule Pune University, Pune, India.
Gajbhiye RL; Organic & Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology, Kolkata 700 032, India.
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Źródło :
Anti-cancer agents in medicinal chemistry [Anticancer Agents Med Chem] 2019; Vol. 19 (9), pp. 1080-1102.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Alkylating Agents/*pharmacology
Antineoplastic Agents, Alkylating/*pharmacology
Neoplasms/*drug therapy
Nitrogen Mustard Compounds/*pharmacology
Alkylating Agents/chemical synthesis ; Alkylating Agents/chemistry ; Antineoplastic Agents, Alkylating/chemical synthesis ; Antineoplastic Agents, Alkylating/chemistry ; Cell Proliferation/drug effects ; Humans ; Neoplasms/pathology ; Nitrogen Mustard Compounds/chemical synthesis ; Nitrogen Mustard Compounds/chemistry ; United States ; United States Food and Drug Administration
Czasopismo naukowe
Tytuł :
Nitrogen Mustards as Anticancer Chemotherapies: Historic Perspective, Current Developments and Future Trends.
Autorzy :
Diethelm-Varela B; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, United States.
Ai Y; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, United States.
Liang D; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, United States.
Xue F; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, United States.
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Źródło :
Current topics in medicinal chemistry [Curr Top Med Chem] 2019; Vol. 19 (9), pp. 691-712.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Agents/*pharmacology
Neoplasms/*drug therapy
Nitrogen Mustard Compounds/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Humans ; Molecular Structure ; Neoplasms/pathology ; Nitrogen Mustard Compounds/chemical synthesis ; Nitrogen Mustard Compounds/chemistry
Czasopismo naukowe
Tytuł :
Modulation of the reactivity of nitrogen mustards by metal complexation: approaches to modify their therapeutic properties.
Autorzy :
Karmakar S; Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur-741246, West Bengal, India. .
Maji M
Mukherjee A
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Źródło :
Dalton transactions (Cambridge, England : 2003) [Dalton Trans] 2019 Jan 22; Vol. 48 (4), pp. 1144-1160.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Coordination Complexes/*therapeutic use
Neoplasms/*drug therapy
Nitrogen Mustard Compounds/*therapeutic use
Antineoplastic Combined Chemotherapy Protocols/chemistry ; Coordination Complexes/chemistry ; Humans ; Molecular Structure ; Nitrogen Mustard Compounds/chemistry
Czasopismo naukowe
Tytuł :
Discovery and Optimization of Novel Hydrogen Peroxide Activated Aromatic Nitrogen Mustard Derivatives as Highly Potent Anticancer Agents.
Autorzy :
Chen W; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery , University of Wisconsin, Milwaukee , 3210 North Cramer Street , Milwaukee , Wisconsin 53211 , United States.
Fan H; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery , University of Wisconsin, Milwaukee , 3210 North Cramer Street , Milwaukee , Wisconsin 53211 , United States.
Balakrishnan K; Department of Experimental Therapeutics , MD Anderson Cancer Center , Houston , Texas 77030 , United States.
Wang Y
Sun H
Fan Y
Gandhi V; Department of Experimental Therapeutics , MD Anderson Cancer Center , Houston , Texas 77030 , United States.
Arnold LA; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery , University of Wisconsin, Milwaukee , 3210 North Cramer Street , Milwaukee , Wisconsin 53211 , United States.
Peng X; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery , University of Wisconsin, Milwaukee , 3210 North Cramer Street , Milwaukee , Wisconsin 53211 , United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2018 Oct 25; Vol. 61 (20), pp. 9132-9145. Date of Electronic Publication: 2018 Oct 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Design*
Antineoplastic Agents, Alkylating/*metabolism
Antineoplastic Agents, Alkylating/*pharmacology
Hydrogen Peroxide/*metabolism
Nitrogen Mustard Compounds/*metabolism
Nitrogen Mustard Compounds/*pharmacology
Antineoplastic Agents, Alkylating/chemistry ; Boronic Acids/chemistry ; Cell Line, Tumor ; Esters/chemistry ; Humans ; Nitrogen Mustard Compounds/chemistry
Czasopismo naukowe
Tytuł :
Therapeutic journery of nitrogen mustard as alkylating anticancer agents: Historic to future perspectives.
Autorzy :
Singh RK; Department of Pharmaceutical Chemistry, Shivalik College of Pharmacy, Nangal, Dist. Rupnagar, 140126, Punjab, India. Electronic address: .
Kumar S; School of Pharmacy and Emerging Sciences, Baddi University of Emerging Sciences & Technology, Baddi, Distt. Solan, 173205, Himachal Pradesh, India.
Prasad DN; Department of Pharmaceutical Chemistry, Shivalik College of Pharmacy, Nangal, Dist. Rupnagar, 140126, Punjab, India.
Bhardwaj TR; School of Pharmacy and Emerging Sciences, Baddi University of Emerging Sciences & Technology, Baddi, Distt. Solan, 173205, Himachal Pradesh, India.
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2018 May 10; Vol. 151, pp. 401-433. Date of Electronic Publication: 2018 Apr 03.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Agents, Alkylating/*chemistry
Antineoplastic Agents, Alkylating/*therapeutic use
Neoplasms/*drug therapy
Nitrogen Mustard Compounds/*chemistry
Nitrogen Mustard Compounds/*therapeutic use
Animals ; Antineoplastic Agents, Alkylating/administration & dosage ; Antineoplastic Agents, Alkylating/pharmacology ; Drug Delivery Systems/methods ; Humans ; Nitrogen Mustard Compounds/administration & dosage ; Nitrogen Mustard Compounds/pharmacology
Czasopismo naukowe
Tytuł :
Biochemistry of N-mustard tumour control compounds reconsidered.
Autorzy :
Robertson DS; Research Chemist, Private Practitioner, Worcestershire, UK.
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Źródło :
Anti-cancer drugs [Anticancer Drugs] 2018 Aug; Vol. 29 (7), pp. 613-615.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Agents/*pharmacology
Neoplasms/*drug therapy
Nitrogen Mustard Compounds/*pharmacology
Antineoplastic Agents/therapeutic use ; Cell Proliferation/drug effects ; Chemistry, Pharmaceutical ; Humans ; Hydrogen Peroxide/metabolism ; Hydroxylamine/metabolism ; Neoplasms/metabolism ; Neoplasms/pathology ; Nitrogen Mustard Compounds/therapeutic use
Czasopismo naukowe
Tytuł :
Drug-DNA adducts as biomarkers for metabolic activation of the nitro-aromatic nitrogen mustard prodrug PR-104A.
Autorzy :
Stornetta A; Department of Health Sciences and Technology, ETH Zurich, Schmelzbergstrasse 9, 8092 Zurich, Switzerland; Masonic Cancer Center, University of Minnesota, 2231 6th Street SE, Minneapolis, MN 5545, United States.
Deng KK; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand.
Danielli S; Department of Health Sciences and Technology, ETH Zurich, Schmelzbergstrasse 9, 8092 Zurich, Switzerland.
Liyanage HDS; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand.
Sturla SJ; Department of Health Sciences and Technology, ETH Zurich, Schmelzbergstrasse 9, 8092 Zurich, Switzerland. Electronic address: .
Wilson WR; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand. Electronic address: .
Gu Y; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand.
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2018 Aug; Vol. 154, pp. 64-74. Date of Electronic Publication: 2018 Apr 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Adducts/*metabolism
DNA Damage/*physiology
Nitrogen Mustard Compounds/*metabolism
Prodrugs/*metabolism
Biomarkers/metabolism ; DNA Damage/drug effects ; HCT116 Cells ; Humans ; Nitrogen Mustard Compounds/pharmacology ; Prodrugs/pharmacology
Czasopismo naukowe
Tytuł :
Inactivation of Plasmodium falciparum in whole blood using the amustaline and glutathione pathogen reduction technology.
Autorzy :
Sow C; MCAM, UMR 7245, Muséum National d'Histoire Naturelle, CNRS, Paris, France.
Laughhunn A; Cerus Corporation, Concord, California.
Girard YA; Cerus Corporation, Concord, California.
Lanteri MC; Cerus Corporation, Concord, California.
Amar El Dusouqui S; Swiss Transfusion SRC, Bern, Switzerland.
Stassinopoulos A; Cerus Corporation, Concord, California.
Grellier P; MCAM, UMR 7245, Muséum National d'Histoire Naturelle, CNRS, Paris, France.
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Źródło :
Transfusion [Transfusion] 2020 Apr; Vol. 60 (4), pp. 799-805. Date of Electronic Publication: 2020 Mar 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acridines/*pharmacology
Glutathione/*pharmacology
Malaria, Falciparum/*prevention & control
Microbial Viability/*drug effects
Nitrogen Mustard Compounds/*pharmacology
Blood Safety/methods ; Erythrocytes/microbiology ; Erythrocytes/parasitology ; Humans ; Malaria, Falciparum/blood ; Malaria, Falciparum/transmission ; Parasite Load ; Parasitemia/drug therapy ; Plasmodium falciparum/drug effects ; Plasmodium falciparum/growth & development
Czasopismo naukowe
Tytuł :
Amustaline (S-303) treatment inactivates high levels of Chikungunya virus in red-blood-cell components.
Autorzy :
Aubry M; Pôle de recherche et de veille sur les maladies infectieuses émergentes, Institut Louis Malardé, Tahiti, French Polynesia.; Aix Marseille Univ, IRD (Dakar, Marseille, Papeete), AP-HM, IHU-Méditerranée Infection, UMR Vecteurs - Infections Tropicales et Méditerranéennes (VITROME), Marseille, France.
Laughhunn A; Cerus Corporation, Concord, CA, USA.
Santa Maria F; Cerus Corporation, Concord, CA, USA.
Lanteri MC; Cerus Corporation, Concord, CA, USA.
Stassinopoulos A; Cerus Corporation, Concord, CA, USA.
Musso D; Pôle de recherche et de veille sur les maladies infectieuses émergentes, Institut Louis Malardé, Tahiti, French Polynesia.; Aix Marseille Univ, IRD (Dakar, Marseille, Papeete), AP-HM, IHU-Méditerranée Infection, UMR Vecteurs - Infections Tropicales et Méditerranéennes (VITROME), Marseille, France.
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Źródło :
Vox sanguinis [Vox Sang] 2018 Apr; Vol. 113 (3), pp. 232-241. Date of Electronic Publication: 2018 Jan 04.
Typ publikacji :
Journal Article
MeSH Terms :
Virus Inactivation*
Acridines/*therapeutic use
Antiviral Agents/*therapeutic use
Blood Safety/*methods
Chikungunya Fever/*prevention & control
Nitrogen Mustard Compounds/*therapeutic use
Acridines/pharmacology ; Antiviral Agents/pharmacology ; Chikungunya Fever/blood ; Chikungunya virus/drug effects ; Erythrocytes/virology ; Humans ; Nitrogen Mustard Compounds/pharmacology ; Viral Load
Czasopismo naukowe
Tytuł :
Preclinical safety assessment of pathogen reduced red blood cells treated with amustaline and glutathione.
Autorzy :
North AK; Cerus Corporation, Concord, California.
Mufti N; Cerus Corporation, Concord, California.
Sullivan T; Cerus Corporation, Concord, California.
Corash L; Cerus Corporation, Concord, California.
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Źródło :
Transfusion [Transfusion] 2020 Feb; Vol. 60 (2), pp. 358-366. Date of Electronic Publication: 2020 Jan 12.
Typ publikacji :
Journal Article
MeSH Terms :
Acridines/*pharmacology
Erythrocytes/*drug effects
Erythrocytes/*metabolism
Glutathione/*pharmacology
Nitrogen Mustard Compounds/*pharmacology
Animals ; Blood-Borne Pathogens/drug effects ; Erythrocyte Transfusion/methods ; Female ; Humans ; Lymphocytes/drug effects ; Lymphocytes/metabolism ; Male ; Mice ; Micronucleus Tests ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Virus Inactivation/drug effects
Czasopismo naukowe
Tytuł :
Extraction-spectrophotometric determination of tris(2-chloroethyl)amine using phthaleins.
Autorzy :
Rozsypal T; Univerzita obrany NBC Defence Institute, Brno, Czech Republic.
Halamek E; Univerzita obrany NBC Defence Institute, Brno, Czech Republic.
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Źródło :
Drug testing and analysis [Drug Test Anal] 2017 Jun; Vol. 9 (6), pp. 916-923. Date of Electronic Publication: 2016 Oct 13.
Typ publikacji :
Evaluation Study; Journal Article
MeSH Terms :
Alkylating Agents/*isolation & purification
Chemical Warfare Agents/*isolation & purification
Nitrogen Mustard Compounds/*isolation & purification
Phenolphthaleins/*chemistry
Alkylating Agents/analysis ; Buffers ; Chemical Warfare Agents/analysis ; Hydrogen-Ion Concentration ; Limit of Detection ; Nitrogen Mustard Compounds/analysis ; Spectrophotometry/methods ; Water/analysis
Czasopismo naukowe
Tytuł :
pH-Sensitive PEGylated liposomes for delivery of an acidic dinitrobenzamide mustard prodrug: Pathways of internalization, cellular trafficking and cytotoxicity to cancer cells.
Autorzy :
Yang MM; School of Pharmacy, The University of Auckland, Auckland 1142, New Zealand.
Wilson WR; Auckland Cancer Society Research Centre, The University of Auckland, New Zealand.
Wu Z; School of Pharmacy, The University of Auckland, Auckland 1142, New Zealand. Electronic address: .
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Źródło :
International journal of pharmaceutics [Int J Pharm] 2017 Jan 10; Vol. 516 (1-2), pp. 323-333. Date of Electronic Publication: 2016 Nov 18.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Drug Delivery Systems*
Antineoplastic Agents/*administration & dosage
Benzamides/*administration & dosage
Mammary Neoplasms, Animal/*drug therapy
Nitrogen Mustard Compounds/*administration & dosage
Animals ; Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/pharmacology ; Benzamides/pharmacokinetics ; Benzamides/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Chromatography, High Pressure Liquid/methods ; Endosomes/metabolism ; Female ; Flow Cytometry ; Hydrogen-Ion Concentration ; Liposomes ; Mammary Neoplasms, Animal/pathology ; Mice ; Microscopy, Confocal ; Nitrogen Mustard Compounds/pharmacokinetics ; Nitrogen Mustard Compounds/pharmacology ; Polyethylene Glycols/chemistry ; Prodrugs ; Solubility ; Transfection
Czasopismo naukowe
Tytuł :
Red blood cell concentrates treated with the amustaline (S-303) pathogen reduction system and stored for 35 days retain post-transfusion viability: results of a two-centre study.
Autorzy :
Cancelas JA; Hoxworth Blood Center, Cincinnati, OH, USA.
Gottschall JL; BloodCenter of Wisconsin, Milwaukee, WI, USA.
Rugg N; Hoxworth Blood Center, Cincinnati, OH, USA.
Graminske S; BloodCenter of Wisconsin, Milwaukee, WI, USA.
Schott MA; Cerus Corporation, Concord, CA, USA.
North A; Cerus Corporation, Concord, CA, USA.
Huang N; Cerus Corporation, Concord, CA, USA.
Mufti N; Cerus Corporation, Concord, CA, USA.
Erickson A; Cerus Corporation, Concord, CA, USA.
Rico S; Cerus Corporation, Concord, CA, USA.
Corash L; Cerus Corporation, Concord, CA, USA.
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Źródło :
Vox sanguinis [Vox Sang] 2017 Apr; Vol. 112 (3), pp. 210-218. Date of Electronic Publication: 2017 Feb 21.
Typ publikacji :
Clinical Trial; Journal Article; Randomized Controlled Trial
MeSH Terms :
Blood Preservation*
Acridines/*pharmacology
Erythrocytes/*drug effects
Nitrogen Mustard Compounds/*pharmacology
Acridines/chemistry ; Adult ; Aged ; Area Under Curve ; Cell Survival/drug effects ; Chromium Isotopes/chemistry ; Cross-Over Studies ; Erythrocyte Count ; Erythrocyte Transfusion/adverse effects ; Erythrocytes/chemistry ; Erythrocytes/cytology ; Erythrocytes/metabolism ; Female ; Half-Life ; Hematoma/etiology ; Humans ; Isotope Labeling ; Male ; Microbial Viability/drug effects ; Middle Aged ; Nitrogen Mustard Compounds/chemistry ; ROC Curve ; Single-Blind Method ; Technetium/chemistry ; Time Factors ; Virus Inactivation/drug effects ; Young Adult
Czasopismo naukowe
Tytuł :
Engineering a Multifunctional Nitroreductase for Improved Activation of Prodrugs and PET Probes for Cancer Gene Therapy.
Autorzy :
Copp JN; School of Biological Sciences, Victoria University of Wellington, Wellington 6012, New Zealand; Centre for Biodiscovery, Victoria University of Wellington, Wellington 6012, New Zealand.
Mowday AM; Auckland Cancer Society Research Centre, School of Medical Sciences, University of Auckland, Auckland 1023, New Zealand.
Williams EM; School of Biological Sciences, Victoria University of Wellington, Wellington 6012, New Zealand; Centre for Biodiscovery, Victoria University of Wellington, Wellington 6012, New Zealand.
Guise CP; Auckland Cancer Society Research Centre, School of Medical Sciences, University of Auckland, Auckland 1023, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, School of Biological Sciences, University of Auckland, Auckland 1010, New Zealand.
Ashoorzadeh A; Auckland Cancer Society Research Centre, School of Medical Sciences, University of Auckland, Auckland 1023, New Zealand.
Sharrock AV; School of Biological Sciences, Victoria University of Wellington, Wellington 6012, New Zealand.
Flanagan JU; Auckland Cancer Society Research Centre, School of Medical Sciences, University of Auckland, Auckland 1023, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, School of Biological Sciences, University of Auckland, Auckland 1010, New Zealand.
Smaill JB; Auckland Cancer Society Research Centre, School of Medical Sciences, University of Auckland, Auckland 1023, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, School of Biological Sciences, University of Auckland, Auckland 1010, New Zealand.
Patterson AV; Auckland Cancer Society Research Centre, School of Medical Sciences, University of Auckland, Auckland 1023, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, School of Biological Sciences, University of Auckland, Auckland 1010, New Zealand.
Ackerley DF; School of Biological Sciences, Victoria University of Wellington, Wellington 6012, New Zealand; Centre for Biodiscovery, Victoria University of Wellington, Wellington 6012, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, School of Biological Sciences, University of Auckland, Auckland 1010, New Zealand. Electronic address: .
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Źródło :
Cell chemical biology [Cell Chem Biol] 2017 Mar 16; Vol. 24 (3), pp. 391-403. Date of Electronic Publication: 2017 Mar 02.
Typ publikacji :
Journal Article
MeSH Terms :
Escherichia coli Proteins/*metabolism
Neoplasms/*therapy
Nitrogen Mustard Compounds/*metabolism
Nitroreductases/*metabolism
Prodrugs/*metabolism
Binding Sites ; Cell Line, Tumor ; Escherichia coli/metabolism ; Escherichia coli Proteins/chemistry ; Escherichia coli Proteins/genetics ; Etanidazole/analogs & derivatives ; Etanidazole/chemistry ; Etanidazole/metabolism ; HCT116 Cells ; Humans ; Hydrocarbons, Fluorinated/chemistry ; Hydrocarbons, Fluorinated/metabolism ; Imidazoles/chemistry ; Imidazoles/metabolism ; Inhibitory Concentration 50 ; Metronidazole/chemistry ; Metronidazole/metabolism ; Molecular Docking Simulation ; Mutagenesis, Site-Directed ; Neoplasms/diagnosis ; Neoplasms/pathology ; Nitrogen Mustard Compounds/chemistry ; Nitroreductases/chemistry ; Nitroreductases/genetics ; Positron-Emission Tomography ; Prodrugs/chemistry ; Protein Structure, Tertiary ; Substrate Specificity ; Triazoles/chemistry ; Triazoles/metabolism
Czasopismo naukowe
Tytuł :
Amustaline (S-303) treatment inactivates high levels of Zika virus in red blood cell components.
Autorzy :
Laughhunn A; Cerus Corporation, Concord, California.
Santa Maria F; Cerus Corporation, Concord, California.
Broult J; Centre de Transfusion Sanguine de la Polynésie Française, Hôpital du Taaone.
Lanteri MC; Cerus Corporation, Concord, California.
Stassinopoulos A; Cerus Corporation, Concord, California.
Musso D; Pôle de Recherche et de Veille sur les Maladies Infectieuses Émergentes, Institut Louis Malardé, Tahiti, Polynésie Française.
Aubry M; Pôle de Recherche et de Veille sur les Maladies Infectieuses Émergentes, Institut Louis Malardé, Tahiti, Polynésie Française.
Pokaż więcej
Źródło :
Transfusion [Transfusion] 2017 Mar; Vol. 57 (3pt2), pp. 779-789. Date of Electronic Publication: 2017 Feb 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Virus Inactivation*
Zika Virus*
Acridines/*pharmacology
Disinfection/*methods
Erythrocytes/*virology
Nitrogen Mustard Compounds/*pharmacology
RNA, Viral/*blood
Acridines/chemistry ; Female ; Humans ; Male ; Nitrogen Mustard Compounds/chemistry
Czasopismo naukowe
Tytuł :
The cellular effects of novel triazine nitrogen mustards in glioblastoma LBC3, LN-18 and LN-229 cell lines.
Autorzy :
Krętowski R; Department of Pharmaceutical Biochemistry, Medical University of Bialystok, Bialystok, Poland.
Drozdowska D; Department of Organic Chemistry, Medical University of Bialystok, Bialystok, Poland.
Kolesińska B; Institute of Organic Chemistry, Technical University of Lodz, Lodz, Poland.
Kamiński Z; Institute of Organic Chemistry, Technical University of Lodz, Lodz, Poland.
Frączyk J; Institute of Organic Chemistry, Technical University of Lodz, Lodz, Poland.
Cechowska-Pasko M; Department of Pharmaceutical Biochemistry, Medical University of Bialystok, Bialystok, Poland. .
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Źródło :
Investigational new drugs [Invest New Drugs] 2019 Oct; Vol. 37 (5), pp. 984-993. Date of Electronic Publication: 2019 Jan 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Cell Proliferation/*drug effects
Glioblastoma/*pathology
Nitrogen Mustard Compounds/*pharmacology
Triazines/*pharmacology
Glioblastoma/drug therapy ; Humans ; Necrosis ; Triazines/chemistry ; Tumor Cells, Cultured
Czasopismo naukowe

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