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Tytuł :
Glutathione reductase: A cytoplasmic antioxidant enzyme and a potential target for phenothiazinium dyes in Neospora caninum.
Autorzy :
Venancio-Brochi JC; Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida do Café, Ribeirão Preto, Brazil.
Pereira LM; Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida do Café, Ribeirão Preto, Brazil.
Calil FA; Laboratório de Cristalografia de Proteínas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, 14040-903 Ribeirão Preto, Brazil; Ludwig Institute for Cancer Research, University of California, School of Medicine, 92093-0669 La Jolla, CA, USA.
Teixera O; Laboratório de Cristalografia de Proteínas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, 14040-903 Ribeirão Preto, Brazil.
Baroni L; Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida do Café, Ribeirão Preto, Brazil.
Abreu-Filho PG; Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida do Café, Ribeirão Preto, Brazil.
Braga GÚL; Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida do Café, Ribeirão Preto, Brazil.
Nonato MC; Laboratório de Cristalografia de Proteínas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, 14040-903 Ribeirão Preto, Brazil.
Yatsuda AP; Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida do Café, Ribeirão Preto, Brazil. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Jul 23. Date of Electronic Publication: 2021 Jul 23.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Druggable hot spots in trypanothione reductase: novel insights and opportunities for drug discovery revealed by DRUGpy.
Autorzy :
Teixeira O; Laboratorio de Cristalografia de Proteínas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto - USP, Address Av. do Café, s/n - Vila Monte Alegre, SP, 14040-903, Ribeirão Preto, Brazil.
Lacerda P; Programa de pós-graduação em Ciências Farmacêuticas da UEFS, Feira de santana, Brazil.; Laboratório de Bioinformática e Modelagem Molecular, Faculdade de Farmácia da Universidade Federal da Bahia, Av. Barão de Jeremoabo s/n Ondina, BA, 40170-115, Salvador, Brasil.
Froes TQ; Laboratorio de Cristalografia de Proteínas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto - USP, Address Av. do Café, s/n - Vila Monte Alegre, SP, 14040-903, Ribeirão Preto, Brazil.
Nonato MC; Laboratorio de Cristalografia de Proteínas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto - USP, Address Av. do Café, s/n - Vila Monte Alegre, SP, 14040-903, Ribeirão Preto, Brazil. .
Castilho MS; Laboratório de Bioinformática e Modelagem Molecular, Faculdade de Farmácia da Universidade Federal da Bahia, Av. Barão de Jeremoabo s/n Ondina, BA, 40170-115, Salvador, Brasil. .
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Źródło :
Journal of computer-aided molecular design [J Comput Aided Mol Des] 2021 Jun 28. Date of Electronic Publication: 2021 Jun 28.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Synthesis and Biological Evaluation of Natural-Product-Inspired, Aminoalkyl-Substituted 1-Benzopyrans as Novel Antiplasmodial Agents.
Autorzy :
Uth JF; Institut für Pharmazeutische und Medizinische Chemie der Westfälischen Wilhelms-Universität Münster, Corrensstraße 48, D-48149 Münster, Germany.
Börgel F; Institut für Pharmazeutische und Medizinische Chemie der Westfälischen Wilhelms-Universität Münster, Corrensstraße 48, D-48149 Münster, Germany.
Lehmkuhl K; Institut für Pharmazeutische und Medizinische Chemie der Westfälischen Wilhelms-Universität Münster, Corrensstraße 48, D-48149 Münster, Germany.
Schepmann D; Institut für Pharmazeutische und Medizinische Chemie der Westfälischen Wilhelms-Universität Münster, Corrensstraße 48, D-48149 Münster, Germany.
Kaiser M; Swiss Tropical and Public Health Institute (Swiss TPH), Socinstraße 57, CH-4002 Basel, Switzerland.
Jabor VAP; Laboratório de Cristalografia de Proteínas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. Café, s/n, 14040-903 Ribeirão Preto, SP, Brazil.
Nonato MC; Laboratório de Cristalografia de Proteínas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. Café, s/n, 14040-903 Ribeirão Preto, SP, Brazil.
Krauth-Siegel RL; Biochemie-Zentrum der Universität Heidelberg (BZH), Im Neuenheimer Feld 328, D-69120 Heidelberg, Germany.
Schmidt TJ; Institut für Pharmazeutische Biologie und Phytochemie der Westfälischen Wilhelms-Universität Münster, Corrensstraße 48, D-48149 Münster, Germany.
Wünsch B; Institut für Pharmazeutische und Medizinische Chemie der Westfälischen Wilhelms-Universität Münster, Corrensstraße 48, D-48149 Münster, Germany.; GRK 2515, Chemical Biology of Ion Channels (Chembion), Westfälische Wilhelms-Universität, 48149 Münster, Germany.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 May 13; Vol. 64 (9), pp. 6397-6409. Date of Electronic Publication: 2021 Apr 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antimalarials/*chemistry
Antimalarials/*pharmacology
Benzopyrans/*chemistry
Benzopyrans/*pharmacology
Biological Products/*chemistry
Plasmodium/*drug effects
Alkylation ; Animals ; Antimalarials/chemical synthesis ; Benzopyrans/chemical synthesis ; Biomimetic Materials/chemical synthesis ; Biomimetic Materials/chemistry ; Biomimetic Materials/pharmacology ; Chemistry Techniques, Synthetic ; Erythrocytes/drug effects ; Erythrocytes/parasitology ; Kinetics ; Mice ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Unraveling the structure and function of CdcPDE: A novel phosphodiesterase from Crotalus durissus collilineatus snake venom.
Autorzy :
Oliveira IS; Department of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
Pucca MB; Medical School, Federal University of Roraima, Boa Vista, RR, Brazil.
Wiezel GA; Department of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
Cardoso IA; Department of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
Bordon KCF; Department of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
Sartim MA; Institute of Biological Sciences, Federal University of Amazonas, Manaus, AM, Brazil; Department of Teaching and Research, Dr. Heitor Vieira Dourado Tropical Medicine Foundation, Manaus, AM, Brazil.
Kalogeropoulos K; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.
Ahmadi S; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.
Baiwir D; Mass Spectrometry Laboratory, MolSys Research Unit, Department of Chemistry, University of Liège, Liège, Belgium; GIGA Proteomics Facility, University of Liège, Liège, Belgium.
Nonato MC; Department of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
Sampaio SV; Department of Clinical Analysis, Toxicology and Food Science, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
Laustsen AH; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.
Auf dem Keller U; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.
Quinton L; Mass Spectrometry Laboratory, MolSys Research Unit, Department of Chemistry, University of Liège, Liège, Belgium.
Arantes EC; Department of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 May 01; Vol. 178, pp. 180-192. Date of Electronic Publication: 2021 Feb 23.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Characterization of class II fumarase from Schistosoma mansoni provides the molecular basis for selective inhibition.
Autorzy :
Cardoso IA; Laboratório de Cristalografia de Proteínas, Departamento de Ciências BioMoleculares, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
de Souza AKL; Laboratório de Cristalografia de Proteínas, Departamento de Ciências BioMoleculares, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
Burgess AMG; The Institute of Biological, Environmental and Rural Sciences (IBERS), Aberystwyth University, Wales, United Kingdom.
Chalmers IW; The Institute of Biological, Environmental and Rural Sciences (IBERS), Aberystwyth University, Wales, United Kingdom.
Hoffmann KF; The Institute of Biological, Environmental and Rural Sciences (IBERS), Aberystwyth University, Wales, United Kingdom.
Nonato MC; Laboratório de Cristalografia de Proteínas, Departamento de Ciências BioMoleculares, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Apr 01; Vol. 175, pp. 406-421. Date of Electronic Publication: 2021 Feb 04.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Structural basis for the function and inhibition of dihydroorotate dehydrogenase from Schistosoma mansoni.
Autorzy :
de Mori RM; Laboratório de Cristalografia de Proteínas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
Aleixo MAA; Laboratório de Cristalografia de Proteínas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
Zapata LCC; Laboratório de Cristalografia de Proteínas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
Calil FA; Laboratório de Cristalografia de Proteínas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
Emery FS; Laboratório de Química Heterocíclica e Medicinal, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
Nonato MC; Laboratório de Cristalografia de Proteínas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
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Źródło :
The FEBS journal [FEBS J] 2021 Feb; Vol. 288 (3), pp. 930-944. Date of Electronic Publication: 2020 Jun 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Enzyme Inhibitors/*pharmacology
Helminth Proteins/*metabolism
Oxidoreductases Acting on CH-CH Group Donors/*metabolism
Schistosoma mansoni/*enzymology
Schistosomiasis mansoni/*prevention & control
Amino Acid Sequence ; Animals ; Atovaquone/analogs & derivatives ; Atovaquone/pharmacology ; Biocatalysis/drug effects ; Catalytic Domain ; Circular Dichroism ; Crystallography, X-Ray ; Enzyme Inhibitors/chemistry ; Helminth Proteins/chemistry ; Helminth Proteins/genetics ; Humans ; Molecular Structure ; Oxidoreductases Acting on CH-CH Group Donors/chemistry ; Oxidoreductases Acting on CH-CH Group Donors/genetics ; Protein Conformation ; Schistosoma mansoni/drug effects ; Schistosoma mansoni/genetics ; Schistosomiasis mansoni/parasitology ; Sequence Homology, Amino Acid
Czasopismo naukowe
Tytuł :
Comparative study between the anti-P. falciparum activity of triazolopyrimidine, pyrazolopyrimidine and quinoline derivatives and the identification of new PfDHODH inhibitors.
Autorzy :
Silveira FF; Laboratorio de Sintese de Farmacos, Instituto de Tecnologia em Farmacos, Farmanguinhos - FIOCRUZ, Fundacao Oswaldo Cruz. Rua Sizenando Nabuco 100, Manguinhos, Rio de Janeiro, RJ, 21041-250, Brazil; Programa de Pós-Graduação em Química, PGQu Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
de Souza JO; Instituto de Física de São Carlos, Universidade de São Paulo, Av. João Dagnone, 1.100, Jd. Santa Angelina, São Carlos, SP, Brazil.
Hoelz LVB; Laboratorio de Sintese de Farmacos, Instituto de Tecnologia em Farmacos, Farmanguinhos - FIOCRUZ, Fundacao Oswaldo Cruz. Rua Sizenando Nabuco 100, Manguinhos, Rio de Janeiro, RJ, 21041-250, Brazil.
Campos VR; Departamento de Química Orgânica, Programa de Pós-Graduação em Química, Instituto de Química, Universidade Federal Fluminense, Niterói, RJ, Brazil.
Jabor VAP; Laboratório de Cristalografia de Proteínas, Departamento de Ciências BioMoleculares, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida do Café s/n Monte Alegre, 14040-903, Ribeirão Preto, SP, Brazil.
Aguiar ACC; Instituto de Física de São Carlos, Universidade de São Paulo, Av. João Dagnone, 1.100, Jd. Santa Angelina, São Carlos, SP, Brazil.
Nonato MC; Laboratório de Cristalografia de Proteínas, Departamento de Ciências BioMoleculares, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida do Café s/n Monte Alegre, 14040-903, Ribeirão Preto, SP, Brazil.
Albuquerque MG; Programa de Pós-Graduação em Química, PGQu Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Guido RVC; Instituto de Física de São Carlos, Universidade de São Paulo, Av. João Dagnone, 1.100, Jd. Santa Angelina, São Carlos, SP, Brazil. Electronic address: .
Boechat N; Laboratorio de Sintese de Farmacos, Instituto de Tecnologia em Farmacos, Farmanguinhos - FIOCRUZ, Fundacao Oswaldo Cruz. Rua Sizenando Nabuco 100, Manguinhos, Rio de Janeiro, RJ, 21041-250, Brazil; Programa de Pós-Graduação em Química, PGQu Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil. Electronic address: .
Pinheiro LCS; Laboratorio de Sintese de Farmacos, Instituto de Tecnologia em Farmacos, Farmanguinhos - FIOCRUZ, Fundacao Oswaldo Cruz. Rua Sizenando Nabuco 100, Manguinhos, Rio de Janeiro, RJ, 21041-250, Brazil. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Jan 01; Vol. 209, pp. 112941. Date of Electronic Publication: 2020 Oct 21.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Antimalarials/*chemical synthesis
Enzyme Inhibitors/*chemistry
Malaria, Falciparum/*drug therapy
Oxidoreductases Acting on CH-CH Group Donors/*antagonists & inhibitors
Pyrimidines/*chemical synthesis
Quinolines/*chemical synthesis
Triazoles/*chemical synthesis
Antimalarials/chemistry ; Antimalarials/pharmacology ; Chloroquine/pharmacology ; Drug Design ; Enzyme Inhibitors/pharmacology ; Hep G2 Cells ; Humans ; Molecular Docking Simulation ; Plasmodium falciparum/drug effects ; Protein Binding ; Pyrimidines/pharmacology ; Quinolines/pharmacology ; Structure-Activity Relationship ; Triazoles/pharmacology
Czasopismo naukowe
Tytuł :
Multimodal small-molecule screening for human prion protein binders.
Autorzy :
Reidenbach AG; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Mesleh MF; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Casalena D; Facilitated Access to Screening Technologies (FAST) Lab, Novartis Institutes for Biomedical Research (NIBR), Cambridge, Massachusetts, USA.
Vallabh SM; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA; Prion Alliance, Cambridge, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA.
Dahlin JL; Harvard Medical School, Boston, Massachusetts, USA; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Leed AJ; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Chan AI; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Usanov DL; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Yehl JB; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Lemke CT; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Campbell AJ; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Shah RN; Undergraduate Research Opportunities Program (UROP), Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Shrestha OK; Facilitated Access to Screening Technologies (FAST) Lab, Novartis Institutes for Biomedical Research (NIBR), Cambridge, Massachusetts, USA.
Sacher JR; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Rangel VL; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Moroco JA; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Sathappa M; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Nonato MC; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Nguyen KT; Artificial Intelligence Molecular Screen (AIMS) Awards Program, Atomwise, San Francisco, California, USA.
Wright SK; Facilitated Access to Screening Technologies (FAST) Lab, Novartis Institutes for Biomedical Research (NIBR), Cambridge, Massachusetts, USA.
Liu DR; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA; Howard Hughes Medical Institute, Chevy Chase, Maryland, USA; Department of Chemistry & Chemical Biology, Harvard University, Cambridge, Massachusetts, USA.
Wagner FF; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Kaushik VK; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Auld DS; Facilitated Access to Screening Technologies (FAST) Lab, Novartis Institutes for Biomedical Research (NIBR), Cambridge, Massachusetts, USA.
Schreiber SL; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA; Department of Chemistry & Chemical Biology, Harvard University, Cambridge, Massachusetts, USA.
Minikel EV; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA; Prion Alliance, Cambridge, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Sep 25; Vol. 295 (39), pp. 13516-13531. Date of Electronic Publication: 2020 Jul 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Benzimidazoles/*pharmacology
Prion Diseases/*drug therapy
Prion Proteins/*antagonists & inhibitors
Small Molecule Libraries/*pharmacology
Benzimidazoles/chemistry ; Drug Discovery ; Drug Evaluation, Preclinical ; Humans ; Magnetic Resonance Spectroscopy ; Prion Diseases/metabolism ; Prion Proteins/metabolism ; Small Molecule Libraries/chemistry
Czasopismo naukowe
Tytuł :
Insights into the structure, function and stability of bordonein-L, the first L-amino acid oxidase from Crotalus durissus terrificus snake venom.
Autorzy :
Wiezel GA; Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. do Café, s/n, 14040-903, Ribeirão Preto, SP, Brazil.
Rustiguel JK; Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. do Café, s/n, 14040-903, Ribeirão Preto, SP, Brazil.
Morgenstern D; Proteomics Resource Center, Langone Medical Center, New York University, 430 East 29th St, 8th Floor, 10016, New York, NY, USA.
Zoccal KF; Department of Clinical Analysis, Toxicology and Food Science, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. do Café, s/n, 14040-903, Ribeirão Preto, SP, Brazil.
Faccioli LH; Department of Clinical Analysis, Toxicology and Food Science, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. do Café, s/n, 14040-903, Ribeirão Preto, SP, Brazil.
Nonato MC; Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. do Café, s/n, 14040-903, Ribeirão Preto, SP, Brazil.
Ueberheide B; Proteomics Resource Center, Langone Medical Center, New York University, 430 East 29th St, 8th Floor, 10016, New York, NY, USA.
Arantes EC; Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. do Café, s/n, 14040-903, Ribeirão Preto, SP, Brazil. Electronic address: .
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Źródło :
Biochimie [Biochimie] 2019 Aug; Vol. 163, pp. 33-49. Date of Electronic Publication: 2019 May 10.
Typ publikacji :
Journal Article
MeSH Terms :
Crotalus/*metabolism
L-Amino Acid Oxidase/*metabolism
Snake Venoms/*enzymology
Amino Acid Sequence ; Animals ; Enzyme Stability ; L-Amino Acid Oxidase/chemistry ; Models, Molecular ; Protein Conformation ; Substrate Specificity ; Tandem Mass Spectrometry
Czasopismo naukowe

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