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Tytuł:
Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth.
Autorzy:
Qiu R; Department of Developmental and Stem Cell Biology, Beckman Research Institute of the City of Hope, Duarte, CA, USA.
Wu J; Division of Comparative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA, USA.
Gudenas B; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Northcott PA; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Wechsler-Reya RJ; Tumor Initiation and Maintenance Program, National Cancer Institute-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Lu Q; Department of Developmental and Stem Cell Biology, Beckman Research Institute of the City of Hope, Duarte, CA, USA. .
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Źródło:
Communications biology [Commun Biol] 2021 May 11; Vol. 4 (1), pp. 552. Date of Electronic Publication: 2021 May 11.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Kinesins/*metabolism
Medulloblastoma/*metabolism
Neural Stem Cells/*metabolism
Animals ; Cell Cycle/genetics ; Cell Differentiation/physiology ; Cell Proliferation/physiology ; Cerebellar Neoplasms/genetics ; Cerebellar Neoplasms/pathology ; Hedgehog Proteins/metabolism ; Kinesins/genetics ; Kinesins/physiology ; Medulloblastoma/physiopathology ; Mice ; Mice, Knockout ; Neural Stem Cells/physiology ; Neurons/metabolism ; Signal Transduction/physiology ; Stem Cells/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Proteomic analysis of Medulloblastoma reveals functional biology with translational potential.
Autorzy:
Rivero-Hinojosa S; Center for Cancer and Immunology Research, Children's Research Institute, Children's National Health System, Washington, DC, USA.
Lau LS; Center for Cancer and Immunology Research, Children's Research Institute, Children's National Health System, Washington, DC, USA.
Stampar M; Center for Cancer and Immunology Research, Children's Research Institute, Children's National Health System, Washington, DC, USA.
Staal J; Center for Cancer and Immunology Research, Children's Research Institute, Children's National Health System, Washington, DC, USA.
Zhang H; Center for Cancer and Immunology Research, Children's Research Institute, Children's National Health System, Washington, DC, USA.
Gordish-Dressman H; Center for Genetic Medicine, Children's Research Institute, Children's National Health System, Washington, DC, USA.
Northcott PA; Department of Pediatric Hematology and Oncology, Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg University Hospital, Heidelberg, Germany.
Pfister SM; Department of Pediatric Hematology and Oncology, Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg University Hospital, Heidelberg, Germany.
Taylor MD; Developmental and Stem Cell Biology Program, Hospital for Sick Children, Toronto, ON, Canada.
Brown KJ; Center for Genetic Medicine, Children's Research Institute, Children's National Health System, Washington, DC, USA.
Rood BR; Center for Cancer and Immunology Research, Children's Research Institute, Children's National Health System, Washington, DC, USA. .; The George Washington University School of Medicine and Health Sciences, Washington DC, USA. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2018 Jun 07; Vol. 6 (1), pp. 48. Date of Electronic Publication: 2018 Jun 07.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Cerebellar Neoplasms/*genetics
Cerebellar Neoplasms/*metabolism
Medulloblastoma/*genetics
Medulloblastoma/*metabolism
Neoplasm Proteins/*genetics
Proteogenomics/*methods
Chromatography, Liquid ; DNA Methylation ; Female ; Humans ; Male ; Neoplasm Proteins/metabolism ; Protein Processing, Post-Translational/physiology ; Proteome ; RNA, Messenger ; Tandem Mass Spectrometry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma.
Autorzy:
Northcott PA; 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany [2].
Lee C; 1] Biomedical Sciences Graduate Program, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093-0685, USA [2] Tumor Initiation and Maintenance Program, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA [3].
Zichner T; 1] European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Meyerhofstrasse 1, Heidelberg 69117, Germany [2].
Stütz AM; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Meyerhofstrasse 1, Heidelberg 69117, Germany.
Erkek S; 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany [2] European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Meyerhofstrasse 1, Heidelberg 69117, Germany.
Kawauchi D; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Shih DJ; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.
Hovestadt V; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Zapatka M; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Sturm D; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Jones DT; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Kool M; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Remke M; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.
Cavalli FM; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.
Zuyderduyn S; The Donnelly Centre, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
Bader GD; The Donnelly Centre, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
VandenBerg S; Department of Pathology, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.
Esparza LA; Tumor Initiation and Maintenance Program, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.
Ryzhova M; Department of Neuropathology, NN Burdenko Neurosurgical Institute, 4th Tverskaya-Yamskaya 16, Moscow 125047, Russia.
Wang W; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Wittmann A; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Stark S; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Sieber L; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Seker-Cin H; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Linke L; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Kratochwil F; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Jäger N; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Buchhalter I; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Imbusch CD; Data Management Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Zipprich G; Data Management Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Raeder B; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Meyerhofstrasse 1, Heidelberg 69117, Germany.
Schmidt S; Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Diessl N; Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Wolf S; Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Wiemann S; Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Brors B; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Lawerenz C; Data Management Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Eils J; Data Management Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Warnatz HJ; Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, Berlin 14195, Germany.
Risch T; Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, Berlin 14195, Germany.
Yaspo ML; Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, Berlin 14195, Germany.
Weber UD; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Bartholomae CC; Division of Translational Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 460, Heidelberg 69120, Germany.
von Kalle C; 1] Division of Translational Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 460, Heidelberg 69120, Germany [2] Heidelberg Center for Personalised Oncology (DKFZ-HIPO), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Turányi E; 1st Department of Pathology and Experimental Cancer Research, Semmelweis University SE, II.sz. Gyermekklinika, Budapest 1094, Hungary.
Hauser P; 2nd Department of Pediatrics, Semmelweis University, SE, II.sz. Gyermekklinika, Budapest 1094, Hungary.
Sanden E; 1] Glioma Immunotherapy Group, Division of Neurosurgery, Lund University, Paradisgatan 2, Lund 221 00, Sweden [2] Department of Clinical Sciences, Lund University, Paradisgatan 2, Lund 221 00, Sweden.
Darabi A; 1] Glioma Immunotherapy Group, Division of Neurosurgery, Lund University, Paradisgatan 2, Lund 221 00, Sweden [2] Department of Clinical Sciences, Lund University, Paradisgatan 2, Lund 221 00, Sweden.
Siesjö P; 1] Glioma Immunotherapy Group, Division of Neurosurgery, Lund University, Paradisgatan 2, Lund 221 00, Sweden [2] Department of Clinical Sciences, Lund University, Paradisgatan 2, Lund 221 00, Sweden.
Sterba J; Department of Pediatric Oncology, Masaryk University and University Hospital, Brno, Cernopolni 9 Brno 613 00, Czech Republic.
Zitterbart K; Department of Pediatric Oncology, Masaryk University and University Hospital, Brno, Cernopolni 9 Brno 613 00, Czech Republic.
Sumerauer D; Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, V Úvalu 84, Prague 150 06, Czech Republic.
van Sluis P; Department of Oncogenomics, AMC, University of Amsterdam, Meibergdreef 9, Amsterdam 1105, AZ Netherlands.
Versteeg R; Department of Oncogenomics, AMC, University of Amsterdam, Meibergdreef 9, Amsterdam 1105, AZ Netherlands.
Volckmann R; Department of Oncogenomics, AMC, University of Amsterdam, Meibergdreef 9, Amsterdam 1105, AZ Netherlands.
Koster J; Department of Oncogenomics, AMC, University of Amsterdam, Meibergdreef 9, Amsterdam 1105, AZ Netherlands.
Schuhmann MU; Department of Neurosurgery, Tübingen University Hospital, Hoppe-Seyler Strasse 3, Tübingen 72076, Germany.
Ebinger M; Department of Neurosurgery, Tübingen University Hospital, Hoppe-Seyler Strasse 3, Tübingen 72076, Germany.
Grimes HL; Division of Immunobiology, Program in Cancer Pathology of the Divisions of Experimental Hematology and Pathology, Program in Hematologic Malignancies of the Cancer and Blood Disease Insitute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 452229, USA.
Robinson GW; 1] Department of Developmental Neurobiology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA [2] Department of Oncology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA.
Gajjar A; Department of Oncology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA.
Mynarek M; Department of Paediatric Haematology and Oncology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, Germany.
von Hoff K; Department of Paediatric Haematology and Oncology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, Germany.
Rutkowski S; Department of Paediatric Haematology and Oncology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, Germany.
Pietsch T; Department of Neuropathology, University of Bonn, Sigmund-Freud-Str. 25, Bonn 53105, Germany.
Scheurlen W; Cnopf'sche Kinderklinik, Nürnberg Children's Hospital, St-Johannis-Mühlgasse 19, Nürnberg 90419, Germany.
Felsberg J; Department of Neuropathology, Heinrich-Heine-University Düsseldorf, Moorenstrasse 5, Düsseldorf 40225, Germany.
Reifenberger G; Department of Neuropathology, Heinrich-Heine-University Düsseldorf, Moorenstrasse 5, Düsseldorf 40225, Germany.
Kulozik AE; Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg 69120, Germany.
von Deimling A; Department of Neuropathology, University of Heidelberg, Im Neuenheimer Feld 220, Heidelberg 69120, Germany.
Witt O; Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg 69120, Germany.
Eils R; 1] Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany [2] Heidelberg Center for Personalised Oncology (DKFZ-HIPO), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Gilbertson RJ; 1] Department of Developmental Neurobiology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA [2] Department of Oncology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA.
Korshunov A; Department of Neuropathology, University of Heidelberg, Im Neuenheimer Feld 220, Heidelberg 69120, Germany.
Taylor MD; 1] The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada [2] Division of Neurosurgery, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.
Lichter P; 1] Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany [2] Heidelberg Center for Personalised Oncology (DKFZ-HIPO), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Korbel JO; 1] European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Meyerhofstrasse 1, Heidelberg 69117, Germany [2] EMBL, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Saffron Walden CB10 1SD, UK.
Wechsler-Reya RJ; Tumor Initiation and Maintenance Program, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.
Pfister SM; 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany [2] Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg 69120, Germany.
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Źródło:
Nature [Nature] 2014 Jul 24; Vol. 511 (7510), pp. 428-34. Date of Electronic Publication: 2014 Jun 22.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA-Binding Proteins/*genetics
Enhancer Elements, Genetic/*genetics
Genomic Structural Variation/*genetics
Medulloblastoma/*genetics
Oncogenes/*genetics
Proto-Oncogene Proteins/*genetics
Repressor Proteins/*genetics
Transcription Factors/*genetics
Animals ; Child ; Chromosomes, Human, Pair 9/genetics ; DNA-Binding Proteins/metabolism ; Humans ; Medulloblastoma/classification ; Medulloblastoma/pathology ; Mice ; Proto-Oncogene Proteins/metabolism ; Repressor Proteins/metabolism ; Transcription Factors/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing.
Autorzy:
Hovestadt V; 1] Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany [2].
Jones DT; 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany [2].
Picelli S; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Wang W; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Kool M; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Northcott PA; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Sultan M; Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, Berlin 14195, Germany.
Stachurski K; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Düsseldorf, Moorenstrasse 5, Düsseldorf 40225, Germany.
Ryzhova M; Department of Neuropathology, NN Burdenko Neurosurgical Institute, 4th Tverskaya-Yamskaya 16, Moscow 125047, Russia.
Warnatz HJ; Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, Berlin 14195, Germany.
Ralser M; Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, Berlin 14195, Germany.
Brun S; Tumor Initiation and Maintenance Program, National Cancer Institute (NCI)-Designated Cancer Center, Sanford-Burnham Medical Research Institute, 2880 Torrey Pines Scenic Drive, La Jolla, California 92037, USA.
Bunt J; 1] Queensland Brain Institute, University of Queensland, QBI Building, St Lucia, Queensland 4072, Australia [2] Department of Oncogenomics, AMC, University of Amsterdam, Meibergdreef 9, Amsterdam 1105 AZ, the Netherlands.
Jäger N; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Kleinheinz K; 1] Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany [2] Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Erkek S; 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany [2] European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, Heidelberg 69117, Germany.
Weber UD; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Bartholomae CC; 1] Division of Translational Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany [2] National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 460, Heidelberg 69120, Germany.
von Kalle C; 1] Division of Translational Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany [2] National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 460, Heidelberg 69120, Germany.
Lawerenz C; Data Management Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Eils J; Data Management Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Koster J; Department of Oncogenomics, AMC, University of Amsterdam, Meibergdreef 9, Amsterdam 1105 AZ, the Netherlands.
Versteeg R; Department of Oncogenomics, AMC, University of Amsterdam, Meibergdreef 9, Amsterdam 1105 AZ, the Netherlands.
Milde T; 1] Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg 69120, Germany [2] Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Witt O; 1] Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg 69120, Germany [2] Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Schmidt S; Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Wolf S; Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Pietsch T; Department of Neuropathology, University of Bonn Medical Center, Sigmund-Freud-Strasse 25, Bonn 53105, Germany.
Rutkowski S; Department of Paediatric Haematology and Oncology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, Germany.
Scheurlen W; Cnopf'sche Kinderklinik, Nürnberg Children's Hospital, St.-Johannis-Mühlgasse 19, Nürnberg 90419, Germany.
Taylor MD; 1] Program in Developmental and Stem Cell Biology, The Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada [2] Division of Neurosurgery, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada [3] Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Brors B; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Felsberg J; 1] Department of Neuropathology, Heinrich Heine University Düsseldorf, Moorenstrasse 5, Düsseldorf 40225, Germany [2] German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Reifenberger G; 1] Department of Neuropathology, Heinrich Heine University Düsseldorf, Moorenstrasse 5, Düsseldorf 40225, Germany [2] German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Borkhardt A; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Düsseldorf, Moorenstrasse 5, Düsseldorf 40225, Germany.
Lehrach H; Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, Berlin 14195, Germany.
Wechsler-Reya RJ; Tumor Initiation and Maintenance Program, National Cancer Institute (NCI)-Designated Cancer Center, Sanford-Burnham Medical Research Institute, 2880 Torrey Pines Scenic Drive, La Jolla, California 92037, USA.
Eils R; 1] Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany [2] Institute of Pharmacy and Molecular Biotechnology (IPMB), University of Heidelberg, Heidelberg 69120, Germany [3] Bioquant Center, University of Heidelberg, Im Neuenheimer Feld 267, Heidelberg 69120, Germany [4] Heidelberg Center for Personalised Oncology (DKFZ-HIPO), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Yaspo ML; Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, Berlin 14195, Germany.
Landgraf P; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Düsseldorf, Moorenstrasse 5, Düsseldorf 40225, Germany.
Korshunov A; 1] Department of Neuropathology, University of Heidelberg, Im Neuenheimer Feld 220, Heidelberg 69120, Germany [2] Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 220-221, Heidelberg, 69120 Germany.
Zapatka M; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Radlwimmer B; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Pfister SM; 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany [2] Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg 69120, Germany.
Lichter P; 1] Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany [2] Heidelberg Center for Personalised Oncology (DKFZ-HIPO), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
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Źródło:
Nature [Nature] 2014 Jun 26; Vol. 510 (7506), pp. 537-41. Date of Electronic Publication: 2014 May 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation, Neoplastic*
Gene Silencing*
DNA Methylation/*genetics
Medulloblastoma/*genetics
Sequence Analysis, DNA/*methods
Animals ; Binding Sites ; Cell Line, Tumor ; Chromatin/genetics ; Chromatin/metabolism ; Chromatin Immunoprecipitation ; Female ; Genome/genetics ; Histones/metabolism ; Humans ; Medulloblastoma/pathology ; Mice ; Promoter Regions, Genetic/genetics ; RNA-Binding Proteins/genetics ; Transcription Factors/metabolism ; Transcription, Genetic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Medulloblastomics: the end of the beginning.
Autorzy:
Northcott PA; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Jones DT
Kool M
Robinson GW
Gilbertson RJ
Cho YJ
Pomeroy SL
Korshunov A
Lichter P
Taylor MD
Pfister SM
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Źródło:
Nature reviews. Cancer [Nat Rev Cancer] 2012 Dec; Vol. 12 (12), pp. 818-34.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Cerebellar Neoplasms/*genetics
Medulloblastoma/*genetics
Animals ; Cerebellar Neoplasms/metabolism ; Child ; Cyclin-Dependent Kinase 6/genetics ; DNA Mutational Analysis ; Female ; Genome-Wide Association Study ; Genomics/methods ; Hedgehog Proteins/genetics ; Hedgehog Proteins/metabolism ; Histones/metabolism ; Humans ; Male ; Medulloblastoma/metabolism ; Mice ; Mutation ; Signal Transduction ; Tetraploidy ; beta Catenin/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations.
Autorzy:
Pugh TJ; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
Weeraratne SD
Archer TC
Pomeranz Krummel DA
Auclair D
Bochicchio J
Carneiro MO
Carter SL
Cibulskis K
Erlich RL
Greulich H
Lawrence MS
Lennon NJ
McKenna A
Meldrim J
Ramos AH
Ross MG
Russ C
Shefler E
Sivachenko A
Sogoloff B
Stojanov P
Tamayo P
Mesirov JP
Amani V
Teider N
Sengupta S
Francois JP
Northcott PA
Taylor MD
Yu F
Crabtree GR
Kautzman AG
Gabriel SB
Getz G
Jäger N
Jones DT
Lichter P
Pfister SM
Roberts TM
Meyerson M
Pomeroy SL
Cho YJ
Pokaż więcej
Źródło:
Nature [Nature] 2012 Aug 02; Vol. 488 (7409), pp. 106-10.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Cerebellar Neoplasms/*genetics
Exome/*genetics
Genome, Human/*genetics
Medulloblastoma/*genetics
Mutation/*genetics
Cerebellar Neoplasms/classification ; Child ; DEAD-box RNA Helicases/chemistry ; DEAD-box RNA Helicases/genetics ; DEAD-box RNA Helicases/metabolism ; DNA Helicases/chemistry ; DNA Helicases/genetics ; DNA-Binding Proteins/genetics ; Hedgehog Proteins/metabolism ; Histone Methyltransferases ; Histone-Lysine N-Methyltransferase/genetics ; Histone-Lysine N-Methyltransferase/metabolism ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; LIM Domain Proteins/genetics ; Medulloblastoma/classification ; Models, Molecular ; Neoplasm Proteins/genetics ; Nuclear Proteins/chemistry ; Nuclear Proteins/genetics ; Patched Receptors ; Patched-1 Receptor ; Promoter Regions, Genetic/genetics ; Protein Structure, Tertiary/genetics ; Proto-Oncogene Proteins/genetics ; Receptors, Cell Surface/genetics ; Repressor Proteins/genetics ; Signal Transduction ; TCF Transcription Factors/metabolism ; Transcription Factors/chemistry ; Transcription Factors/genetics ; Tumor Suppressor Protein p53/genetics ; Wnt Proteins/metabolism ; beta Catenin/genetics ; beta Catenin/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Subgroup-specific structural variation across 1,000 medulloblastoma genomes.
Autorzy:
Northcott PA; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
Shih DJ
Peacock J
Garzia L
Morrissy AS
Zichner T
Stütz AM
Korshunov A
Reimand J
Schumacher SE
Beroukhim R
Ellison DW
Marshall CR
Lionel AC
Mack S
Dubuc A
Yao Y
Ramaswamy V
Luu B
Rolider A
Cavalli FM
Wang X
Remke M
Wu X
Chiu RY
Chu A
Chuah E
Corbett RD
Hoad GR
Jackman SD
Li Y
Lo A
Mungall KL
Nip KM
Qian JQ
Raymond AG
Thiessen NT
Varhol RJ
Birol I
Moore RA
Mungall AJ
Holt R
Kawauchi D
Roussel MF
Kool M
Jones DT
Witt H
Fernandez-L A
Kenney AM
Wechsler-Reya RJ
Dirks P
Aviv T
Grajkowska WA
Perek-Polnik M
Haberler CC
Delattre O
Reynaud SS
Doz FF
Pernet-Fattet SS
Cho BK
Kim SK
Wang KC
Scheurlen W
Eberhart CG
Fèvre-Montange M
Jouvet A
Pollack IF
Fan X
Muraszko KM
Gillespie GY
Di Rocco C
Massimi L
Michiels EM
Kloosterhof NK
French PJ
Kros JM
Olson JM
Ellenbogen RG
Zitterbart K
Kren L
Thompson RC
Cooper MK
Lach B
McLendon RE
Bigner DD
Fontebasso A
Albrecht S
Jabado N
Lindsey JC
Bailey S
Gupta N
Weiss WA
Bognár L
Klekner A
Van Meter TE
Kumabe T
Tominaga T
Elbabaa SK
Leonard JR
Rubin JB
Liau LM
Van Meir EG
Fouladi M
Nakamura H
Cinalli G
Garami M
Hauser P
Saad AG
Iolascon A
Jung S
Carlotti CG
Vibhakar R
Ra YS
Robinson S
Zollo M
Faria CC
Chan JA
Levy ML
Sorensen PH
Meyerson M
Pomeroy SL
Cho YJ
Bader GD
Tabori U
Hawkins CE
Bouffet E
Scherer SW
Rutka JT
Malkin D
Clifford SC
Jones SJ
Korbel JO
Pfister SM
Marra MA
Taylor MD
Pokaż więcej
Źródło:
Nature [Nature] 2012 Aug 02; Vol. 488 (7409), pp. 49-56.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Cerebellar Neoplasms/*classification
Cerebellar Neoplasms/*genetics
Genome, Human/*genetics
Genomic Structural Variation/*genetics
Medulloblastoma/*classification
Medulloblastoma/*genetics
Carrier Proteins/genetics ; Cerebellar Neoplasms/metabolism ; Child ; DNA Copy Number Variations/genetics ; Gene Duplication/genetics ; Genes, myc/genetics ; Genomics ; Hedgehog Proteins/metabolism ; Humans ; Medulloblastoma/metabolism ; NF-kappa B/metabolism ; Nerve Tissue Proteins/genetics ; Oncogene Proteins, Fusion/genetics ; Proteins/genetics ; RNA, Long Noncoding ; Signal Transduction ; Transforming Growth Factor beta/metabolism ; Translocation, Genetic/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Dissecting the genomic complexity underlying medulloblastoma.
Autorzy:
Jones DT; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Jäger N
Kool M
Zichner T
Hutter B
Sultan M
Cho YJ
Pugh TJ
Hovestadt V
Stütz AM
Rausch T
Warnatz HJ
Ryzhova M
Bender S
Sturm D
Pleier S
Cin H
Pfaff E
Sieber L
Wittmann A
Remke M
Witt H
Hutter S
Tzaridis T
Weischenfeldt J
Raeder B
Avci M
Amstislavskiy V
Zapatka M
Weber UD
Wang Q
Lasitschka B
Bartholomae CC
Schmidt M
von Kalle C
Ast V
Lawerenz C
Eils J
Kabbe R
Benes V
van Sluis P
Koster J
Volckmann R
Shih D
Betts MJ
Russell RB
Coco S
Tonini GP
Schüller U
Hans V
Graf N
Kim YJ
Monoranu C
Roggendorf W
Unterberg A
Herold-Mende C
Milde T
Kulozik AE
von Deimling A
Witt O
Maass E
Rössler J
Ebinger M
Schuhmann MU
Frühwald MC
Hasselblatt M
Jabado N
Rutkowski S
von Bueren AO
Williamson D
Clifford SC
McCabe MG
Collins VP
Wolf S
Wiemann S
Lehrach H
Brors B
Scheurlen W
Felsberg J
Reifenberger G
Northcott PA
Taylor MD
Meyerson M
Pomeroy SL
Yaspo ML
Korbel JO
Korshunov A
Eils R
Pfister SM
Lichter P
Pokaż więcej
Źródło:
Nature [Nature] 2012 Aug 02; Vol. 488 (7409), pp. 100-5.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cerebellar Neoplasms/*genetics
Genome, Human/*genetics
Medulloblastoma/*genetics
Aging/genetics ; Amino Acid Sequence ; Cell Transformation, Neoplastic ; Cerebellar Neoplasms/classification ; Cerebellar Neoplasms/diagnosis ; Cerebellar Neoplasms/pathology ; Child ; Chromatin/metabolism ; Chromosomes, Human/genetics ; DEAD-box RNA Helicases/genetics ; DNA Helicases/genetics ; DNA-Binding Proteins/genetics ; Genomics ; Hedgehog Proteins/metabolism ; High-Throughput Nucleotide Sequencing ; Histone Demethylases/genetics ; Humans ; Medulloblastoma/classification ; Medulloblastoma/diagnosis ; Medulloblastoma/pathology ; Methylation ; Mutation/genetics ; Mutation Rate ; Neoplasm Proteins/genetics ; Nuclear Proteins/genetics ; Oncogene Proteins, Fusion/genetics ; Patched Receptors ; Patched-1 Receptor ; Phosphoprotein Phosphatases/genetics ; Polyploidy ; Receptors, Cell Surface/genetics ; Sequence Analysis, RNA ; Signal Transduction ; T-Box Domain Proteins/genetics ; Transcription Factors/genetics ; Wnt Proteins/metabolism ; beta Catenin/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Clonal selection drives genetic divergence of metastatic medulloblastoma.
Autorzy:
Wu X; Arthur and Sonia Labatt Brain Tumour Research Center, Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
Northcott PA
Dubuc A
Dupuy AJ
Shih DJ
Witt H
Croul S
Bouffet E
Fults DW
Eberhart CG
Garzia L
Van Meter T
Zagzag D
Jabado N
Schwartzentruber J
Majewski J
Scheetz TE
Pfister SM
Korshunov A
Li XN
Scherer SW
Cho YJ
Akagi K
MacDonald TJ
Koster J
McCabe MG
Sarver AL
Collins VP
Weiss WA
Largaespada DA
Collier LS
Taylor MD
Pokaż więcej
Źródło:
Nature [Nature] 2012 Feb 15; Vol. 482 (7386), pp. 529-33. Date of Electronic Publication: 2012 Feb 15.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Clonal Evolution/*genetics
Medulloblastoma/*genetics
Medulloblastoma/*pathology
Neoplasm Metastasis/*genetics
Neoplasm Metastasis/*pathology
Animals ; CpG Islands/genetics ; DNA Methylation ; DNA Transposable Elements/genetics ; Disease Models, Animal ; Genes, p53/genetics ; Germ-Line Mutation/genetics ; Humans ; Li-Fraumeni Syndrome/complications ; Li-Fraumeni Syndrome/genetics ; Medulloblastoma/complications ; Mice ; Mutagenesis, Insertional ; Survival Rate
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The genetic landscape of the childhood cancer medulloblastoma.
Autorzy:
Parsons DW; Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA.
Li M
Zhang X
Jones S
Leary RJ
Lin JC
Boca SM
Carter H
Samayoa J
Bettegowda C
Gallia GL
Jallo GI
Binder ZA
Nikolsky Y
Hartigan J
Smith DR
Gerhard DS
Fults DW
VandenBerg S
Berger MS
Marie SK
Shinjo SM
Clara C
Phillips PC
Minturn JE
Biegel JA
Judkins AR
Resnick AC
Storm PB
Curran T
He Y
Rasheed BA
Friedman HS
Keir ST
McLendon R
Northcott PA
Taylor MD
Burger PC
Riggins GJ
Karchin R
Parmigiani G
Bigner DD
Yan H
Papadopoulos N
Vogelstein B
Kinzler KW
Velculescu VE
Pokaż więcej
Źródło:
Science (New York, N.Y.) [Science] 2011 Jan 28; Vol. 331 (6016), pp. 435-9. Date of Electronic Publication: 2010 Dec 16.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Genes, Neoplasm*
Mutation*
Cerebellar Neoplasms/*genetics
Medulloblastoma/*genetics
Adult ; Cerebellar Neoplasms/metabolism ; Child ; DNA Copy Number Variations ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Genes, Tumor Suppressor ; Histone-Lysine N-Methyltransferase/genetics ; Histone-Lysine N-Methyltransferase/metabolism ; Histones/metabolism ; Humans ; Medulloblastoma/metabolism ; Methylation ; MicroRNAs/genetics ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Oligonucleotide Array Sequence Analysis ; Point Mutation ; Sequence Analysis, DNA ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma.
Autorzy:
Northcott PA; Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada.
Nakahara Y
Wu X
Feuk L
Ellison DW
Croul S
Mack S
Kongkham PN
Peacock J
Dubuc A
Ra YS
Zilberberg K
McLeod J
Scherer SW
Sunil Rao J
Eberhart CG
Grajkowska W
Gillespie Y
Lach B
Grundy R
Pollack IF
Hamilton RL
Van Meter T
Carlotti CG
Boop F
Bigner D
Gilbertson RJ
Rutka JT
Taylor MD
Pokaż więcej
Źródło:
Nature genetics [Nat Genet] 2009 Apr; Vol. 41 (4), pp. 465-72. Date of Electronic Publication: 2009 Mar 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cerebellar Neoplasms/*genetics
Medulloblastoma/*genetics
Cerebellar Neoplasms/enzymology ; Gene Amplification ; Gene Deletion ; Genes, Tumor Suppressor ; Genome, Human ; Histone-Lysine N-Methyltransferase/genetics ; Histones/metabolism ; Humans ; Lysine/metabolism ; Medulloblastoma/enzymology ; Polymorphism, Single Nucleotide ; Protein Processing, Post-Translational/genetics ; Sequence Deletion
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Patient-derived orthotopic xenografts of pediatric brain tumors: a St. Jude resource
Autorzy:
Smith, Kyle S.
Xu, Ke
Mercer, Kimberly S.
Boop, Frederick
Klimo, Paul
DeCupyere, Michael
Grenet, Jose
Robinson, Sarah
Dunphy, PaigeAff1, Aff7
Baker, Suzanne J.
Ellison, David W.
Merchant, Thomas E.
Upadayaya, Santhosh A.
Gajjar, Amar
Wu, Gang
Orr, Brent A.
Robinson, Giles W.
Northcott, Paul A.
Roussel, Martine F.
Pokaż więcej
Źródło:
Acta Neuropathologica: Pathology and Mechanisms of Neurological Disease. 140(2):209-225
Czasopismo naukowe
Szczegóły
Tytuł:
Second-generation molecular subgrouping of medulloblastoma: an international meta-analysis of Group 3 and Group 4 subtypes
Autorzy:
Sharma, TanviAff1, Aff2, Aff3
Schwalbe, Edward C.Aff5, Aff6
Williamson, Daniel
Sill, MartinAff1, Aff2
Hovestadt, VolkerAff7, Aff8
Mynarek, Martin
Rutkowski, Stefan
Robinson, Giles W.
Gajjar, Amar
Cavalli, Florence
Ramaswamy, VijayAff11, Aff12
Taylor, Michael D.Aff11, Aff13
Lindsey, Janet C.
Hill, Rebecca M.
Jäger, NatalieAff1, Aff2
Korshunov, Andrey
Hicks, Debbie
Bailey, Simon
Kool, MarcelAff1, Aff2
Chavez, Lukas
Northcott, Paul A.
Pfister, Stefan M.Aff1, Aff2, Aff4
Clifford, Steven C.
Pokaż więcej
Źródło:
Acta Neuropathologica: Pathology and Mechanisms of Neurological Disease. 138(2):309-326
Czasopismo naukowe
Szczegóły
Tytuł:
Risk stratification of childhood medulloblastoma in the molecular era: the current consensus
Autorzy:
Ramaswamy, Vijay
Remke, Marc
Bouffet, Eric
Bailey, Simon
Clifford, Steven C.
Doz, Francois
Kool, Marcel
Dufour, Christelle
Vassal, Gilles
Milde, Till
Witt, Olaf
von Hoff, Katja
Pietsch, Torsten
Northcott, Paul A.
Gajjar, Amar
Robinson, Giles W.
Padovani, Laetitia
André, Nicolas
Massimino, Maura
Pizer, Barry
Packer, Roger
Rutkowski, Stefan
Pfister, Stefan M.
Taylor, Michael D.
Pomeroy, Scott L.
Pokaż więcej
Źródło:
Acta Neuropathologica: Pathology and Mechanisms of Neurological Disease. June 2016 131(6):821-831
Czasopismo naukowe
Szczegóły
Tytuł:
Prognostic significance of clinical, histopathological, and molecular characteristics of medulloblastomas in the prospective HIT2000 multicenter clinical trial cohort
Autorzy:
Pietsch, Torsten
Schmidt, Rene
Remke, Marc
Korshunov, Andrey
Hovestadt, Volker
Jones, David T. W.
Felsberg, Jörg
Kaulich, Kerstin
Goschzik, Tobias
Kool, Marcel
Northcott, Paul A.
von Hoff, Katja
von Bueren, André O.
Friedrich, Carsten
Mynarek, Martin
Skladny, Heyko
Fleischhack, Gudrun
Taylor, Michael D.
Cremer, Friedrich
Lichter, Peter
Faldum, Andreas
Reifenberger, Guido
Rutkowski, Stefan
Pfister, Stefan M.
Pokaż więcej
Źródło:
Acta Neuropathologica: Pathology and Mechanisms of Neurological Disease. July 2014 128(1):137-149
Czasopismo naukowe
Szczegóły
Wyświetlanie 1-20 z 156

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