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    Wyświetlanie 1-19 z 19
    Tytuł:
    Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth.
    Autorzy:
    Qiu R; Department of Developmental and Stem Cell Biology, Beckman Research Institute of the City of Hope, Duarte, CA, USA.
    Wu J; Division of Comparative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA, USA.
    Gudenas B; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA.
    Northcott PA; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA.
    Wechsler-Reya RJ; Tumor Initiation and Maintenance Program, National Cancer Institute-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
    Lu Q; Department of Developmental and Stem Cell Biology, Beckman Research Institute of the City of Hope, Duarte, CA, USA. .
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    Źródło:
    Communications biology [Commun Biol] 2021 May 11; Vol. 4 (1), pp. 552. Date of Electronic Publication: 2021 May 11.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural
    MeSH Terms:
    Kinesins/*metabolism
    Medulloblastoma/*metabolism
    Neural Stem Cells/*metabolism
    Animals ; Cell Cycle/genetics ; Cell Differentiation/physiology ; Cell Proliferation/physiology ; Cerebellar Neoplasms/genetics ; Cerebellar Neoplasms/pathology ; Hedgehog Proteins/metabolism ; Kinesins/genetics ; Kinesins/physiology ; Medulloblastoma/physiopathology ; Mice ; Mice, Knockout ; Neural Stem Cells/physiology ; Neurons/metabolism ; Signal Transduction/physiology ; Stem Cells/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    TelomereHunter - in silico estimation of telomere content and composition from cancer genomes.
    Autorzy:
    Feuerbach L; Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. .
    Sieverling L; Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, 69120, Heidelberg, Germany.
    Deeg KI; Research Group Genome Organization & Function/Division of Chromatin Networks, German Cancer Research Center (DKFZ) and BioQuant Center, 69120, Heidelberg, Germany.
    Ginsbach P; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
    Hutter B; Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
    Buchhalter I; Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
    Northcott PA; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
    Mughal SS; Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, 69120, Heidelberg, Germany.
    Chudasama P; Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
    Glimm H; Translational Functional Cancer Genomics, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Dresden, University Hospital Carl Gustav Carus, Dresden and DKFZ, Heidelberg, Germany.; German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.
    Scholl C; Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.; German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.; Division of Applied Functional Genomics, DKFZ, 69120, Heidelberg, Germany.
    Lichter P; German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.; Division of Molecular Genetics, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
    Fröhling S; Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.; German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.
    Pfister SM; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.; German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.; Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), 69120, Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, 69120, Heidelberg, Germany.
    Jones DTW; German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.; Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), 69120, Heidelberg, Germany.; Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
    Rippe K; Research Group Genome Organization & Function/Division of Chromatin Networks, German Cancer Research Center (DKFZ) and BioQuant Center, 69120, Heidelberg, Germany.
    Brors B; Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.; German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.
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    Źródło:
    BMC bioinformatics [BMC Bioinformatics] 2019 May 28; Vol. 20 (1), pp. 272. Date of Electronic Publication: 2019 May 28.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Computer Simulation*
    Genome*
    Software*
    Neoplasms/*genetics
    Telomere/*genetics
    Base Sequence ; Glioblastoma/genetics ; High-Throughput Nucleotide Sequencing ; Humans ; Medulloblastoma/genetics ; Exome Sequencing ; Whole Genome Sequencing
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Proteomic analysis of Medulloblastoma reveals functional biology with translational potential.
    Autorzy:
    Rivero-Hinojosa S; Center for Cancer and Immunology Research, Children's Research Institute, Children's National Health System, Washington, DC, USA.
    Lau LS; Center for Cancer and Immunology Research, Children's Research Institute, Children's National Health System, Washington, DC, USA.
    Stampar M; Center for Cancer and Immunology Research, Children's Research Institute, Children's National Health System, Washington, DC, USA.
    Staal J; Center for Cancer and Immunology Research, Children's Research Institute, Children's National Health System, Washington, DC, USA.
    Zhang H; Center for Cancer and Immunology Research, Children's Research Institute, Children's National Health System, Washington, DC, USA.
    Gordish-Dressman H; Center for Genetic Medicine, Children's Research Institute, Children's National Health System, Washington, DC, USA.
    Northcott PA; Department of Pediatric Hematology and Oncology, Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg University Hospital, Heidelberg, Germany.
    Pfister SM; Department of Pediatric Hematology and Oncology, Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg University Hospital, Heidelberg, Germany.
    Taylor MD; Developmental and Stem Cell Biology Program, Hospital for Sick Children, Toronto, ON, Canada.
    Brown KJ; Center for Genetic Medicine, Children's Research Institute, Children's National Health System, Washington, DC, USA.
    Rood BR; Center for Cancer and Immunology Research, Children's Research Institute, Children's National Health System, Washington, DC, USA. .; The George Washington University School of Medicine and Health Sciences, Washington DC, USA. .
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    Źródło:
    Acta neuropathologica communications [Acta Neuropathol Commun] 2018 Jun 07; Vol. 6 (1), pp. 48. Date of Electronic Publication: 2018 Jun 07.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Cerebellar Neoplasms/*genetics
    Cerebellar Neoplasms/*metabolism
    Medulloblastoma/*genetics
    Medulloblastoma/*metabolism
    Neoplasm Proteins/*genetics
    Proteogenomics/*methods
    Chromatography, Liquid ; DNA Methylation ; Female ; Humans ; Male ; Neoplasm Proteins/metabolism ; Protein Processing, Post-Translational/physiology ; Proteome ; RNA, Messenger ; Tandem Mass Spectrometry
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    The WIP1 oncogene promotes progression and invasion of aggressive medulloblastoma variants.
    Autorzy:
    Buss MC; Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA.
    Remke M; Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Center, Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
    Lee J; Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA.
    Gandhi K; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.
    Schniederjan MJ; Department of Pathology, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA.
    Kool M; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    Northcott PA; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    Pfister SM; 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany [2] Department of Pediatric Hematology, Oncology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.
    Taylor MD; Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Center, Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
    Castellino RC; Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA.
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    Źródło:
    Oncogene [Oncogene] 2015 Feb 26; Vol. 34 (9), pp. 1126-40. Date of Electronic Publication: 2014 Mar 17.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Cerebellar Neoplasms/*pathology
    Chemokine CXCL2/*metabolism
    G-Protein-Coupled Receptor Kinase 5/*metabolism
    Medulloblastoma/*pathology
    Phosphoprotein Phosphatases/*genetics
    Receptors, CXCR4/*genetics
    Adolescent ; Animals ; Cell Line, Tumor ; Cerebellar Neoplasms/genetics ; Child ; Child, Preschool ; Female ; G-Protein-Coupled Receptor Kinase 5/genetics ; Humans ; Infant ; Male ; Medulloblastoma/genetics ; Mice ; Mice, SCID ; Neoplasm Invasiveness ; Neoplasm Transplantation ; Phosphoprotein Phosphatases/metabolism ; Protein Phosphatase 2C ; Receptors, CXCR4/metabolism ; Signal Transduction ; Young Adult
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma.
    Autorzy:
    Northcott PA; 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany [2].
    Lee C; 1] Biomedical Sciences Graduate Program, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093-0685, USA [2] Tumor Initiation and Maintenance Program, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA [3].
    Zichner T; 1] European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Meyerhofstrasse 1, Heidelberg 69117, Germany [2].
    Stütz AM; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Meyerhofstrasse 1, Heidelberg 69117, Germany.
    Erkek S; 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany [2] European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Meyerhofstrasse 1, Heidelberg 69117, Germany.
    Kawauchi D; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Shih DJ; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.
    Hovestadt V; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Zapatka M; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Sturm D; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Jones DT; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Kool M; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Remke M; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.
    Cavalli FM; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.
    Zuyderduyn S; The Donnelly Centre, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
    Bader GD; The Donnelly Centre, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
    VandenBerg S; Department of Pathology, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.
    Esparza LA; Tumor Initiation and Maintenance Program, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.
    Ryzhova M; Department of Neuropathology, NN Burdenko Neurosurgical Institute, 4th Tverskaya-Yamskaya 16, Moscow 125047, Russia.
    Wang W; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Wittmann A; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Stark S; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Sieber L; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Seker-Cin H; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Linke L; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Kratochwil F; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Jäger N; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Buchhalter I; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Imbusch CD; Data Management Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Zipprich G; Data Management Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Raeder B; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Meyerhofstrasse 1, Heidelberg 69117, Germany.
    Schmidt S; Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Diessl N; Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Wolf S; Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Wiemann S; Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Brors B; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Lawerenz C; Data Management Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Eils J; Data Management Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Warnatz HJ; Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, Berlin 14195, Germany.
    Risch T; Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, Berlin 14195, Germany.
    Yaspo ML; Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, Berlin 14195, Germany.
    Weber UD; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Bartholomae CC; Division of Translational Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 460, Heidelberg 69120, Germany.
    von Kalle C; 1] Division of Translational Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 460, Heidelberg 69120, Germany [2] Heidelberg Center for Personalised Oncology (DKFZ-HIPO), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Turányi E; 1st Department of Pathology and Experimental Cancer Research, Semmelweis University SE, II.sz. Gyermekklinika, Budapest 1094, Hungary.
    Hauser P; 2nd Department of Pediatrics, Semmelweis University, SE, II.sz. Gyermekklinika, Budapest 1094, Hungary.
    Sanden E; 1] Glioma Immunotherapy Group, Division of Neurosurgery, Lund University, Paradisgatan 2, Lund 221 00, Sweden [2] Department of Clinical Sciences, Lund University, Paradisgatan 2, Lund 221 00, Sweden.
    Darabi A; 1] Glioma Immunotherapy Group, Division of Neurosurgery, Lund University, Paradisgatan 2, Lund 221 00, Sweden [2] Department of Clinical Sciences, Lund University, Paradisgatan 2, Lund 221 00, Sweden.
    Siesjö P; 1] Glioma Immunotherapy Group, Division of Neurosurgery, Lund University, Paradisgatan 2, Lund 221 00, Sweden [2] Department of Clinical Sciences, Lund University, Paradisgatan 2, Lund 221 00, Sweden.
    Sterba J; Department of Pediatric Oncology, Masaryk University and University Hospital, Brno, Cernopolni 9 Brno 613 00, Czech Republic.
    Zitterbart K; Department of Pediatric Oncology, Masaryk University and University Hospital, Brno, Cernopolni 9 Brno 613 00, Czech Republic.
    Sumerauer D; Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, V Úvalu 84, Prague 150 06, Czech Republic.
    van Sluis P; Department of Oncogenomics, AMC, University of Amsterdam, Meibergdreef 9, Amsterdam 1105, AZ Netherlands.
    Versteeg R; Department of Oncogenomics, AMC, University of Amsterdam, Meibergdreef 9, Amsterdam 1105, AZ Netherlands.
    Volckmann R; Department of Oncogenomics, AMC, University of Amsterdam, Meibergdreef 9, Amsterdam 1105, AZ Netherlands.
    Koster J; Department of Oncogenomics, AMC, University of Amsterdam, Meibergdreef 9, Amsterdam 1105, AZ Netherlands.
    Schuhmann MU; Department of Neurosurgery, Tübingen University Hospital, Hoppe-Seyler Strasse 3, Tübingen 72076, Germany.
    Ebinger M; Department of Neurosurgery, Tübingen University Hospital, Hoppe-Seyler Strasse 3, Tübingen 72076, Germany.
    Grimes HL; Division of Immunobiology, Program in Cancer Pathology of the Divisions of Experimental Hematology and Pathology, Program in Hematologic Malignancies of the Cancer and Blood Disease Insitute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 452229, USA.
    Robinson GW; 1] Department of Developmental Neurobiology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA [2] Department of Oncology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA.
    Gajjar A; Department of Oncology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA.
    Mynarek M; Department of Paediatric Haematology and Oncology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, Germany.
    von Hoff K; Department of Paediatric Haematology and Oncology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, Germany.
    Rutkowski S; Department of Paediatric Haematology and Oncology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, Germany.
    Pietsch T; Department of Neuropathology, University of Bonn, Sigmund-Freud-Str. 25, Bonn 53105, Germany.
    Scheurlen W; Cnopf'sche Kinderklinik, Nürnberg Children's Hospital, St-Johannis-Mühlgasse 19, Nürnberg 90419, Germany.
    Felsberg J; Department of Neuropathology, Heinrich-Heine-University Düsseldorf, Moorenstrasse 5, Düsseldorf 40225, Germany.
    Reifenberger G; Department of Neuropathology, Heinrich-Heine-University Düsseldorf, Moorenstrasse 5, Düsseldorf 40225, Germany.
    Kulozik AE; Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg 69120, Germany.
    von Deimling A; Department of Neuropathology, University of Heidelberg, Im Neuenheimer Feld 220, Heidelberg 69120, Germany.
    Witt O; Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg 69120, Germany.
    Eils R; 1] Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany [2] Heidelberg Center for Personalised Oncology (DKFZ-HIPO), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Gilbertson RJ; 1] Department of Developmental Neurobiology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA [2] Department of Oncology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA.
    Korshunov A; Department of Neuropathology, University of Heidelberg, Im Neuenheimer Feld 220, Heidelberg 69120, Germany.
    Taylor MD; 1] The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada [2] Division of Neurosurgery, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.
    Lichter P; 1] Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany [2] Heidelberg Center for Personalised Oncology (DKFZ-HIPO), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Korbel JO; 1] European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Meyerhofstrasse 1, Heidelberg 69117, Germany [2] EMBL, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Saffron Walden CB10 1SD, UK.
    Wechsler-Reya RJ; Tumor Initiation and Maintenance Program, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.
    Pfister SM; 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany [2] Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg 69120, Germany.
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    Źródło:
    Nature [Nature] 2014 Jul 24; Vol. 511 (7510), pp. 428-34. Date of Electronic Publication: 2014 Jun 22.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    DNA-Binding Proteins/*genetics
    Enhancer Elements, Genetic/*genetics
    Genomic Structural Variation/*genetics
    Medulloblastoma/*genetics
    Oncogenes/*genetics
    Proto-Oncogene Proteins/*genetics
    Repressor Proteins/*genetics
    Transcription Factors/*genetics
    Animals ; Child ; Chromosomes, Human, Pair 9/genetics ; DNA-Binding Proteins/metabolism ; Humans ; Medulloblastoma/classification ; Medulloblastoma/pathology ; Mice ; Proto-Oncogene Proteins/metabolism ; Repressor Proteins/metabolism ; Transcription Factors/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing.
    Autorzy:
    Hovestadt V; 1] Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany [2].
    Jones DT; 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany [2].
    Picelli S; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Wang W; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Kool M; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Northcott PA; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Sultan M; Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, Berlin 14195, Germany.
    Stachurski K; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Düsseldorf, Moorenstrasse 5, Düsseldorf 40225, Germany.
    Ryzhova M; Department of Neuropathology, NN Burdenko Neurosurgical Institute, 4th Tverskaya-Yamskaya 16, Moscow 125047, Russia.
    Warnatz HJ; Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, Berlin 14195, Germany.
    Ralser M; Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, Berlin 14195, Germany.
    Brun S; Tumor Initiation and Maintenance Program, National Cancer Institute (NCI)-Designated Cancer Center, Sanford-Burnham Medical Research Institute, 2880 Torrey Pines Scenic Drive, La Jolla, California 92037, USA.
    Bunt J; 1] Queensland Brain Institute, University of Queensland, QBI Building, St Lucia, Queensland 4072, Australia [2] Department of Oncogenomics, AMC, University of Amsterdam, Meibergdreef 9, Amsterdam 1105 AZ, the Netherlands.
    Jäger N; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Kleinheinz K; 1] Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany [2] Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Erkek S; 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany [2] European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, Heidelberg 69117, Germany.
    Weber UD; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Bartholomae CC; 1] Division of Translational Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany [2] National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 460, Heidelberg 69120, Germany.
    von Kalle C; 1] Division of Translational Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany [2] National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 460, Heidelberg 69120, Germany.
    Lawerenz C; Data Management Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Eils J; Data Management Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Koster J; Department of Oncogenomics, AMC, University of Amsterdam, Meibergdreef 9, Amsterdam 1105 AZ, the Netherlands.
    Versteeg R; Department of Oncogenomics, AMC, University of Amsterdam, Meibergdreef 9, Amsterdam 1105 AZ, the Netherlands.
    Milde T; 1] Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg 69120, Germany [2] Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Witt O; 1] Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg 69120, Germany [2] Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Schmidt S; Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Wolf S; Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Pietsch T; Department of Neuropathology, University of Bonn Medical Center, Sigmund-Freud-Strasse 25, Bonn 53105, Germany.
    Rutkowski S; Department of Paediatric Haematology and Oncology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, Germany.
    Scheurlen W; Cnopf'sche Kinderklinik, Nürnberg Children's Hospital, St.-Johannis-Mühlgasse 19, Nürnberg 90419, Germany.
    Taylor MD; 1] Program in Developmental and Stem Cell Biology, The Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada [2] Division of Neurosurgery, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada [3] Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
    Brors B; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Felsberg J; 1] Department of Neuropathology, Heinrich Heine University Düsseldorf, Moorenstrasse 5, Düsseldorf 40225, Germany [2] German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Reifenberger G; 1] Department of Neuropathology, Heinrich Heine University Düsseldorf, Moorenstrasse 5, Düsseldorf 40225, Germany [2] German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Borkhardt A; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Düsseldorf, Moorenstrasse 5, Düsseldorf 40225, Germany.
    Lehrach H; Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, Berlin 14195, Germany.
    Wechsler-Reya RJ; Tumor Initiation and Maintenance Program, National Cancer Institute (NCI)-Designated Cancer Center, Sanford-Burnham Medical Research Institute, 2880 Torrey Pines Scenic Drive, La Jolla, California 92037, USA.
    Eils R; 1] Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany [2] Institute of Pharmacy and Molecular Biotechnology (IPMB), University of Heidelberg, Heidelberg 69120, Germany [3] Bioquant Center, University of Heidelberg, Im Neuenheimer Feld 267, Heidelberg 69120, Germany [4] Heidelberg Center for Personalised Oncology (DKFZ-HIPO), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Yaspo ML; Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, Berlin 14195, Germany.
    Landgraf P; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Düsseldorf, Moorenstrasse 5, Düsseldorf 40225, Germany.
    Korshunov A; 1] Department of Neuropathology, University of Heidelberg, Im Neuenheimer Feld 220, Heidelberg 69120, Germany [2] Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 220-221, Heidelberg, 69120 Germany.
    Zapatka M; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Radlwimmer B; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Pfister SM; 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany [2] Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg 69120, Germany.
    Lichter P; 1] Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany [2] Heidelberg Center for Personalised Oncology (DKFZ-HIPO), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Pokaż więcej
    Źródło:
    Nature [Nature] 2014 Jun 26; Vol. 510 (7506), pp. 537-41. Date of Electronic Publication: 2014 May 18.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Gene Expression Regulation, Neoplastic*
    Gene Silencing*
    DNA Methylation/*genetics
    Medulloblastoma/*genetics
    Sequence Analysis, DNA/*methods
    Animals ; Binding Sites ; Cell Line, Tumor ; Chromatin/genetics ; Chromatin/metabolism ; Chromatin Immunoprecipitation ; Female ; Genome/genetics ; Histones/metabolism ; Humans ; Medulloblastoma/pathology ; Mice ; Promoter Regions, Genetic/genetics ; RNA-Binding Proteins/genetics ; Transcription Factors/metabolism ; Transcription, Genetic
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Epigenomic alterations define lethal CIMP-positive ependymomas of infancy.
    Autorzy:
    Mack SC; 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada [3] Division of Neurosurgery, University of Toronto, Toronto, Ontario M5S 1A8, Canada [4].
    Witt H; 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg 69120, Germany [3] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [4].
    Piro RM; 1] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [2] Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
    Gu L; 1] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [2] Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
    Zuyderduyn S; Department of Molecular Genetics, Banting and Best Department of Medical Research, The Donnelly Centre, University of Toronto, Toronto, Ontario M4N 1X8, Canada.
    Stütz AM; 1] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [2] Genome Biology, European Molecular Biology, Laboratory Meyerhofstr. 1, Heidelberg 69117, Germany.
    Wang X; 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
    Gallo M; Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
    Garzia L; Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
    Zayne K; Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
    Zhang X; Department of Genetics, Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA.
    Ramaswamy V; 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
    Jäger N; 1] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [2] Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
    Jones DT; 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany.
    Sill M; 1] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [2] Division of Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
    Pugh TJ; Department of Neurology, Harvard Medical School, Children's Hospital Boston, MIT, Boston, Massachusetts 02115, USA.
    Ryzhova M; 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany.
    Wani KM; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
    Shih DJ; 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
    Head R; Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
    Remke M; 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
    Bailey SD; 1] Ontario Cancer Institute, Princess Margaret Cancer Centre-University Health Network, Toronto, Ontario M5G 1L7, Canada [2] Ontario Institute for Cancer Research, Toronto, Ontario M5G 1L7, Canada.
    Zichner T; 1] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [2] Genome Biology, European Molecular Biology, Laboratory Meyerhofstr. 1, Heidelberg 69117, Germany.
    Faria CC; Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
    Barszczyk M; 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
    Stark S; 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany.
    Seker-Cin H; 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany.
    Hutter S; 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany.
    Johann P; 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany.
    Bender S; 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany.
    Hovestadt V; 1] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [2] Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
    Tzaridis T; 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany.
    Dubuc AM; 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
    Northcott PA; 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany.
    Peacock J; 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
    Bertrand KC; 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
    Agnihotri S; Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
    Cavalli FM; Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
    Clarke I; Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
    Nethery-Brokx K; Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
    Creasy CL; Cancer Epigenetics Discovery Performance Unit, GlaxoSmithKline Pharmaceuticals, Collegeville, Pennsylvania 19426, USA.
    Verma SK; Cancer Epigenetics Discovery Performance Unit, GlaxoSmithKline Pharmaceuticals, Collegeville, Pennsylvania 19426, USA.
    Koster J; Department of Oncogenomics, Academic Medical Center, Amsterdam 1105, The Netherlands.
    Wu X; Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
    Yao Y; 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
    Milde T; 1] Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg 69120, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [3] CCU Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
    Sin-Chan P; Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
    Zuccaro J; Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
    Lau L; Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
    Pereira S; Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
    Castelo-Branco P; Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
    Hirst M; 1] Centre for High-Throughput Biology, Department of Microbiology & Immunology, University of British Columbia, Vancouver, V6T 1Z4 British Columbia, Canada [2] Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada.
    Marra MA; 1] Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada [2] Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6H 3N1, Canada.
    Roberts SS; Department of Pediatrics and National Capital Consortium, Uniformed Services University, Bethesda, Maryland 20814, USA.
    Fults D; Department of Neurosurgery, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA.
    Massimi L; Pediatric Neurosurgery, Catholic University Medical School, Gemelli Hospital, Rome 00168, Italy.
    Cho YJ; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA.
    Van Meter T; Department of Pediatrics, Virginia Commonwealth, Richmond, Virginia 23298-0646, USA.
    Grajkowska W; Department of Pathology, University of Warsaw, Children's Memorial Health Institute University of Warsaw, Warsaw 04-730, Poland.
    Lach B; Division of Anatomical Pathology, Department of Pathology and Molecular Medicine, McMaster University, Hamilton General Hospital, Hamilton, Ontario L8S 4K1, Canada.
    Kulozik AE; 1] Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg 69120, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany.
    von Deimling A; 1] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [2] Department of Neuropathology Ruprecht-Karls-University Heidelberg, Institute of Pathology, Heidelberg 69120, Germany.
    Witt O; 1] Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg 69120, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [3] CCU Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
    Scherer SW; Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
    Fan X; 1] University of Michigan Cell and Developmental Biology, Ann Arbor, Michigan 48109-2200, USA [2] Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
    Muraszko KM; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
    Kool M; 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany.
    Pomeroy SL; Department of Neurology, Harvard Medical School, Children's Hospital Boston, MIT, Boston, Massachusetts 02115, USA.
    Gupta N; Department of Neurosurgery, University of California San Francisco, San Francisco, California 94143-0112, USA.
    Phillips J; Departments of Neurology, Pediatrics, and Neurosurgery, University of California, San Francisco, The Helen Diller Family Cancer Research Building, San Francisco, California 94158, USA.
    Huang A; 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Department of Neuro-oncology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
    Tabori U; 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Department of Neuro-oncology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
    Hawkins C; 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
    Malkin D; Department of Haematology and Oncology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
    Kongkham PN; 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada [3] Division of Neurosurgery, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
    Weiss WA; Departments of Neurology, Pediatrics, and Neurosurgery, University of California, San Francisco, The Helen Diller Family Cancer Research Building, San Francisco, California 94158, USA.
    Jabado N; Departments of Pediatrics and Human Genetics, McGill University and the McGill University Health Center Research Institute, Montreal, Quebec H3Z 2Z3, Canada.
    Rutka JT; 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada [3] Division of Neurosurgery, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
    Bouffet E; Department of Neuro-oncology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
    Korbel JO; Genome Biology, European Molecular Biology, Laboratory Meyerhofstr. 1, Heidelberg 69117, Germany.
    Lupien M; 1] Ontario Cancer Institute, Princess Margaret Cancer Centre-University Health Network, Toronto, Ontario M5G 1L7, Canada [2] Ontario Institute for Cancer Research, Toronto, Ontario M5G 1L7, Canada [3] Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1X8, Canada.
    Aldape KD; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
    Bader GD; Department of Molecular Genetics, Banting and Best Department of Medical Research, The Donnelly Centre, University of Toronto, Toronto, Ontario M4N 1X8, Canada.
    Eils R; 1] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [2] Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
    Lichter P; 1] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [2] Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
    Dirks PB; 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada [3] Division of Neurosurgery, University of Toronto, Toronto, Ontario M5S 1A8, Canada [4] Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
    Pfister SM; 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg 69120, Germany [3] German Cancer Consortium (DKTK), Heidelberg 69120, Germany.
    Korshunov A; 1] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [2] University of Michigan Cell and Developmental Biology, Ann Arbor, Michigan 48109-2200, USA [3] CCU Neuropathology, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
    Taylor MD; 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada [3] Division of Neurosurgery, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
    Pokaż więcej
    Źródło:
    Nature [Nature] 2014 Feb 27; Vol. 506 (7489), pp. 445-50. Date of Electronic Publication: 2014 Feb 19.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    CpG Islands/*genetics
    Ependymoma/*genetics
    Epigenesis, Genetic/*genetics
    Animals ; Brain Neoplasms/drug therapy ; Brain Neoplasms/genetics ; DNA Methylation/drug effects ; Embryonic Stem Cells/metabolism ; Ependymoma/drug therapy ; Epigenomics ; Female ; Gene Expression Regulation, Neoplastic ; Gene Silencing/drug effects ; Histones/drug effects ; Histones/metabolism ; Humans ; Infant ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Mutation/genetics ; Phenotype ; Polycomb Repressive Complex 2/metabolism ; Prognosis ; Rhombencephalon/pathology ; Xenograft Model Antitumor Assays
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Signatures of mutational processes in human cancer.
    Autorzy:
    Alexandrov LB; Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.
    Nik-Zainal S
    Wedge DC
    Aparicio SA
    Behjati S
    Biankin AV
    Bignell GR
    Bolli N
    Borg A
    Børresen-Dale AL
    Boyault S
    Burkhardt B
    Butler AP
    Caldas C
    Davies HR
    Desmedt C
    Eils R
    Eyfjörd JE
    Foekens JA
    Greaves M
    Hosoda F
    Hutter B
    Ilicic T
    Imbeaud S
    Imielinski M
    Jäger N
    Jones DT
    Jones D
    Knappskog S
    Kool M
    Lakhani SR
    López-Otín C
    Martin S
    Munshi NC
    Nakamura H
    Northcott PA
    Pajic M
    Papaemmanuil E
    Paradiso A
    Pearson JV
    Puente XS
    Raine K
    Ramakrishna M
    Richardson AL
    Richter J
    Rosenstiel P
    Schlesner M
    Schumacher TN
    Span PN
    Teague JW
    Totoki Y
    Tutt AN
    Valdés-Mas R
    van Buuren MM
    van 't Veer L
    Vincent-Salomon A
    Waddell N
    Yates LR
    Zucman-Rossi J
    Futreal PA
    McDermott U
    Lichter P
    Meyerson M
    Grimmond SM
    Siebert R
    Campo E
    Shibata T
    Pfister SM
    Campbell PJ
    Stratton MR
    Pokaż więcej
    Corporate Authors:
    Australian Pancreatic Cancer Genome Initiative
    ICGC Breast Cancer Consortium
    ICGC MMML-Seq Consortium
    ICGC PedBrain
    Źródło:
    Nature [Nature] 2013 Aug 22; Vol. 500 (7463), pp. 415-21. Date of Electronic Publication: 2013 Aug 14.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Cell Transformation, Neoplastic/*genetics
    Mutagenesis/*genetics
    Mutation/*genetics
    Neoplasms/*genetics
    Aging/genetics ; Algorithms ; Cell Transformation, Neoplastic/pathology ; Cytidine Deaminase/genetics ; DNA/genetics ; DNA/metabolism ; DNA Mutational Analysis ; Humans ; Models, Genetic ; Mutagenesis, Insertional/genetics ; Mutagens/pharmacology ; Neoplasms/enzymology ; Neoplasms/pathology ; Organ Specificity ; Reproducibility of Results ; Sequence Deletion/genetics ; Transcription, Genetic/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.
    Autorzy:
    Jones DT; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    Hutter B
    Jäger N
    Korshunov A
    Kool M
    Warnatz HJ
    Zichner T
    Lambert SR
    Ryzhova M
    Quang DA
    Fontebasso AM
    Stütz AM
    Hutter S
    Zuckermann M
    Sturm D
    Gronych J
    Lasitschka B
    Schmidt S
    Seker-Cin H
    Witt H
    Sultan M
    Ralser M
    Northcott PA
    Hovestadt V
    Bender S
    Pfaff E
    Stark S
    Faury D
    Schwartzentruber J
    Majewski J
    Weber UD
    Zapatka M
    Raeder B
    Schlesner M
    Worth CL
    Bartholomae CC
    von Kalle C
    Imbusch CD
    Radomski S
    Lawerenz C
    van Sluis P
    Koster J
    Volckmann R
    Versteeg R
    Lehrach H
    Monoranu C
    Winkler B
    Unterberg A
    Herold-Mende C
    Milde T
    Kulozik AE
    Ebinger M
    Schuhmann MU
    Cho YJ
    Pomeroy SL
    von Deimling A
    Witt O
    Taylor MD
    Wolf S
    Karajannis MA
    Eberhart CG
    Scheurlen W
    Hasselblatt M
    Ligon KL
    Kieran MW
    Korbel JO
    Yaspo ML
    Brors B
    Felsberg J
    Reifenberger G
    Collins VP
    Jabado N
    Eils R
    Lichter P
    Pfister SM
    Pokaż więcej
    Corporate Authors:
    International Cancer Genome Consortium PedBrain Tumor Project
    Źródło:
    Nature genetics [Nat Genet] 2013 Aug; Vol. 45 (8), pp. 927-32. Date of Electronic Publication: 2013 Jun 30.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Mutation*
    Astrocytoma/*genetics
    Brain Neoplasms/*genetics
    Receptor, Fibroblast Growth Factor, Type 1/*genetics
    Receptor, trkB/*genetics
    Animals ; Astrocytoma/metabolism ; Base Sequence ; Brain Neoplasms/metabolism ; Cell Line ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; Chromosome Breakpoints ; Chromosomes, Human, Pair 6 ; Chromosomes, Human, Pair 9 ; Fibroblast Growth Factors/metabolism ; Humans ; MAP Kinase Signaling System ; Mice ; Models, Molecular ; Oncogene Proteins, Fusion/chemistry ; Oncogene Proteins, Fusion/genetics ; Protein Conformation ; Proto-Oncogene Proteins B-raf/chemistry ; Proto-Oncogene Proteins B-raf/genetics ; Receptor, Fibroblast Growth Factor, Type 1/metabolism ; Receptor, trkB/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Medulloblastomics: the end of the beginning.
    Autorzy:
    Northcott PA; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Jones DT
    Kool M
    Robinson GW
    Gilbertson RJ
    Cho YJ
    Pomeroy SL
    Korshunov A
    Lichter P
    Taylor MD
    Pfister SM
    Pokaż więcej
    Źródło:
    Nature reviews. Cancer [Nat Rev Cancer] 2012 Dec; Vol. 12 (12), pp. 818-34.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
    MeSH Terms:
    Cerebellar Neoplasms/*genetics
    Medulloblastoma/*genetics
    Animals ; Cerebellar Neoplasms/metabolism ; Child ; Cyclin-Dependent Kinase 6/genetics ; DNA Mutational Analysis ; Female ; Genome-Wide Association Study ; Genomics/methods ; Hedgehog Proteins/genetics ; Hedgehog Proteins/metabolism ; Histones/metabolism ; Humans ; Male ; Medulloblastoma/metabolism ; Mice ; Mutation ; Signal Transduction ; Tetraploidy ; beta Catenin/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations.
    Autorzy:
    Pugh TJ; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
    Weeraratne SD
    Archer TC
    Pomeranz Krummel DA
    Auclair D
    Bochicchio J
    Carneiro MO
    Carter SL
    Cibulskis K
    Erlich RL
    Greulich H
    Lawrence MS
    Lennon NJ
    McKenna A
    Meldrim J
    Ramos AH
    Ross MG
    Russ C
    Shefler E
    Sivachenko A
    Sogoloff B
    Stojanov P
    Tamayo P
    Mesirov JP
    Amani V
    Teider N
    Sengupta S
    Francois JP
    Northcott PA
    Taylor MD
    Yu F
    Crabtree GR
    Kautzman AG
    Gabriel SB
    Getz G
    Jäger N
    Jones DT
    Lichter P
    Pfister SM
    Roberts TM
    Meyerson M
    Pomeroy SL
    Cho YJ
    Pokaż więcej
    Źródło:
    Nature [Nature] 2012 Aug 02; Vol. 488 (7409), pp. 106-10.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Cerebellar Neoplasms/*genetics
    Exome/*genetics
    Genome, Human/*genetics
    Medulloblastoma/*genetics
    Mutation/*genetics
    Cerebellar Neoplasms/classification ; Child ; DEAD-box RNA Helicases/chemistry ; DEAD-box RNA Helicases/genetics ; DEAD-box RNA Helicases/metabolism ; DNA Helicases/chemistry ; DNA Helicases/genetics ; DNA-Binding Proteins/genetics ; Hedgehog Proteins/metabolism ; Histone Methyltransferases ; Histone-Lysine N-Methyltransferase/genetics ; Histone-Lysine N-Methyltransferase/metabolism ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; LIM Domain Proteins/genetics ; Medulloblastoma/classification ; Models, Molecular ; Neoplasm Proteins/genetics ; Nuclear Proteins/chemistry ; Nuclear Proteins/genetics ; Patched Receptors ; Patched-1 Receptor ; Promoter Regions, Genetic/genetics ; Protein Structure, Tertiary/genetics ; Proto-Oncogene Proteins/genetics ; Receptors, Cell Surface/genetics ; Repressor Proteins/genetics ; Signal Transduction ; TCF Transcription Factors/metabolism ; Transcription Factors/chemistry ; Transcription Factors/genetics ; Tumor Suppressor Protein p53/genetics ; Wnt Proteins/metabolism ; beta Catenin/genetics ; beta Catenin/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Subgroup-specific structural variation across 1,000 medulloblastoma genomes.
    Autorzy:
    Northcott PA; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
    Shih DJ
    Peacock J
    Garzia L
    Morrissy AS
    Zichner T
    Stütz AM
    Korshunov A
    Reimand J
    Schumacher SE
    Beroukhim R
    Ellison DW
    Marshall CR
    Lionel AC
    Mack S
    Dubuc A
    Yao Y
    Ramaswamy V
    Luu B
    Rolider A
    Cavalli FM
    Wang X
    Remke M
    Wu X
    Chiu RY
    Chu A
    Chuah E
    Corbett RD
    Hoad GR
    Jackman SD
    Li Y
    Lo A
    Mungall KL
    Nip KM
    Qian JQ
    Raymond AG
    Thiessen NT
    Varhol RJ
    Birol I
    Moore RA
    Mungall AJ
    Holt R
    Kawauchi D
    Roussel MF
    Kool M
    Jones DT
    Witt H
    Fernandez-L A
    Kenney AM
    Wechsler-Reya RJ
    Dirks P
    Aviv T
    Grajkowska WA
    Perek-Polnik M
    Haberler CC
    Delattre O
    Reynaud SS
    Doz FF
    Pernet-Fattet SS
    Cho BK
    Kim SK
    Wang KC
    Scheurlen W
    Eberhart CG
    Fèvre-Montange M
    Jouvet A
    Pollack IF
    Fan X
    Muraszko KM
    Gillespie GY
    Di Rocco C
    Massimi L
    Michiels EM
    Kloosterhof NK
    French PJ
    Kros JM
    Olson JM
    Ellenbogen RG
    Zitterbart K
    Kren L
    Thompson RC
    Cooper MK
    Lach B
    McLendon RE
    Bigner DD
    Fontebasso A
    Albrecht S
    Jabado N
    Lindsey JC
    Bailey S
    Gupta N
    Weiss WA
    Bognár L
    Klekner A
    Van Meter TE
    Kumabe T
    Tominaga T
    Elbabaa SK
    Leonard JR
    Rubin JB
    Liau LM
    Van Meir EG
    Fouladi M
    Nakamura H
    Cinalli G
    Garami M
    Hauser P
    Saad AG
    Iolascon A
    Jung S
    Carlotti CG
    Vibhakar R
    Ra YS
    Robinson S
    Zollo M
    Faria CC
    Chan JA
    Levy ML
    Sorensen PH
    Meyerson M
    Pomeroy SL
    Cho YJ
    Bader GD
    Tabori U
    Hawkins CE
    Bouffet E
    Scherer SW
    Rutka JT
    Malkin D
    Clifford SC
    Jones SJ
    Korbel JO
    Pfister SM
    Marra MA
    Taylor MD
    Pokaż więcej
    Źródło:
    Nature [Nature] 2012 Aug 02; Vol. 488 (7409), pp. 49-56.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Cerebellar Neoplasms/*classification
    Cerebellar Neoplasms/*genetics
    Genome, Human/*genetics
    Genomic Structural Variation/*genetics
    Medulloblastoma/*classification
    Medulloblastoma/*genetics
    Carrier Proteins/genetics ; Cerebellar Neoplasms/metabolism ; Child ; DNA Copy Number Variations/genetics ; Gene Duplication/genetics ; Genes, myc/genetics ; Genomics ; Hedgehog Proteins/metabolism ; Humans ; Medulloblastoma/metabolism ; NF-kappa B/metabolism ; Nerve Tissue Proteins/genetics ; Oncogene Proteins, Fusion/genetics ; Proteins/genetics ; RNA, Long Noncoding ; Signal Transduction ; Transforming Growth Factor beta/metabolism ; Translocation, Genetic/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Dissecting the genomic complexity underlying medulloblastoma.
    Autorzy:
    Jones DT; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Jäger N
    Kool M
    Zichner T
    Hutter B
    Sultan M
    Cho YJ
    Pugh TJ
    Hovestadt V
    Stütz AM
    Rausch T
    Warnatz HJ
    Ryzhova M
    Bender S
    Sturm D
    Pleier S
    Cin H
    Pfaff E
    Sieber L
    Wittmann A
    Remke M
    Witt H
    Hutter S
    Tzaridis T
    Weischenfeldt J
    Raeder B
    Avci M
    Amstislavskiy V
    Zapatka M
    Weber UD
    Wang Q
    Lasitschka B
    Bartholomae CC
    Schmidt M
    von Kalle C
    Ast V
    Lawerenz C
    Eils J
    Kabbe R
    Benes V
    van Sluis P
    Koster J
    Volckmann R
    Shih D
    Betts MJ
    Russell RB
    Coco S
    Tonini GP
    Schüller U
    Hans V
    Graf N
    Kim YJ
    Monoranu C
    Roggendorf W
    Unterberg A
    Herold-Mende C
    Milde T
    Kulozik AE
    von Deimling A
    Witt O
    Maass E
    Rössler J
    Ebinger M
    Schuhmann MU
    Frühwald MC
    Hasselblatt M
    Jabado N
    Rutkowski S
    von Bueren AO
    Williamson D
    Clifford SC
    McCabe MG
    Collins VP
    Wolf S
    Wiemann S
    Lehrach H
    Brors B
    Scheurlen W
    Felsberg J
    Reifenberger G
    Northcott PA
    Taylor MD
    Meyerson M
    Pomeroy SL
    Yaspo ML
    Korbel JO
    Korshunov A
    Eils R
    Pfister SM
    Lichter P
    Pokaż więcej
    Źródło:
    Nature [Nature] 2012 Aug 02; Vol. 488 (7409), pp. 100-5.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Cerebellar Neoplasms/*genetics
    Genome, Human/*genetics
    Medulloblastoma/*genetics
    Aging/genetics ; Amino Acid Sequence ; Cell Transformation, Neoplastic ; Cerebellar Neoplasms/classification ; Cerebellar Neoplasms/diagnosis ; Cerebellar Neoplasms/pathology ; Child ; Chromatin/metabolism ; Chromosomes, Human/genetics ; DEAD-box RNA Helicases/genetics ; DNA Helicases/genetics ; DNA-Binding Proteins/genetics ; Genomics ; Hedgehog Proteins/metabolism ; High-Throughput Nucleotide Sequencing ; Histone Demethylases/genetics ; Humans ; Medulloblastoma/classification ; Medulloblastoma/diagnosis ; Medulloblastoma/pathology ; Methylation ; Mutation/genetics ; Mutation Rate ; Neoplasm Proteins/genetics ; Nuclear Proteins/genetics ; Oncogene Proteins, Fusion/genetics ; Patched Receptors ; Patched-1 Receptor ; Phosphoprotein Phosphatases/genetics ; Polyploidy ; Receptors, Cell Surface/genetics ; Sequence Analysis, RNA ; Signal Transduction ; T-Box Domain Proteins/genetics ; Transcription Factors/genetics ; Wnt Proteins/metabolism ; beta Catenin/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Clonal selection drives genetic divergence of metastatic medulloblastoma.
    Autorzy:
    Wu X; Arthur and Sonia Labatt Brain Tumour Research Center, Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
    Northcott PA
    Dubuc A
    Dupuy AJ
    Shih DJ
    Witt H
    Croul S
    Bouffet E
    Fults DW
    Eberhart CG
    Garzia L
    Van Meter T
    Zagzag D
    Jabado N
    Schwartzentruber J
    Majewski J
    Scheetz TE
    Pfister SM
    Korshunov A
    Li XN
    Scherer SW
    Cho YJ
    Akagi K
    MacDonald TJ
    Koster J
    McCabe MG
    Sarver AL
    Collins VP
    Weiss WA
    Largaespada DA
    Collier LS
    Taylor MD
    Pokaż więcej
    Źródło:
    Nature [Nature] 2012 Feb 15; Vol. 482 (7386), pp. 529-33. Date of Electronic Publication: 2012 Feb 15.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Clonal Evolution/*genetics
    Medulloblastoma/*genetics
    Medulloblastoma/*pathology
    Neoplasm Metastasis/*genetics
    Neoplasm Metastasis/*pathology
    Animals ; CpG Islands/genetics ; DNA Methylation ; DNA Transposable Elements/genetics ; Disease Models, Animal ; Genes, p53/genetics ; Germ-Line Mutation/genetics ; Humans ; Li-Fraumeni Syndrome/complications ; Li-Fraumeni Syndrome/genetics ; Medulloblastoma/complications ; Mice ; Mutagenesis, Insertional ; Survival Rate
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    The genetic landscape of the childhood cancer medulloblastoma.
    Autorzy:
    Parsons DW; Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA.
    Li M
    Zhang X
    Jones S
    Leary RJ
    Lin JC
    Boca SM
    Carter H
    Samayoa J
    Bettegowda C
    Gallia GL
    Jallo GI
    Binder ZA
    Nikolsky Y
    Hartigan J
    Smith DR
    Gerhard DS
    Fults DW
    VandenBerg S
    Berger MS
    Marie SK
    Shinjo SM
    Clara C
    Phillips PC
    Minturn JE
    Biegel JA
    Judkins AR
    Resnick AC
    Storm PB
    Curran T
    He Y
    Rasheed BA
    Friedman HS
    Keir ST
    McLendon R
    Northcott PA
    Taylor MD
    Burger PC
    Riggins GJ
    Karchin R
    Parmigiani G
    Bigner DD
    Yan H
    Papadopoulos N
    Vogelstein B
    Kinzler KW
    Velculescu VE
    Pokaż więcej
    Źródło:
    Science (New York, N.Y.) [Science] 2011 Jan 28; Vol. 331 (6016), pp. 435-9. Date of Electronic Publication: 2010 Dec 16.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Genes, Neoplasm*
    Mutation*
    Cerebellar Neoplasms/*genetics
    Medulloblastoma/*genetics
    Adult ; Cerebellar Neoplasms/metabolism ; Child ; DNA Copy Number Variations ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Genes, Tumor Suppressor ; Histone-Lysine N-Methyltransferase/genetics ; Histone-Lysine N-Methyltransferase/metabolism ; Histones/metabolism ; Humans ; Medulloblastoma/metabolism ; Methylation ; MicroRNAs/genetics ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Oligonucleotide Array Sequence Analysis ; Point Mutation ; Sequence Analysis, DNA ; Signal Transduction
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    The SFRP family of WNT inhibitors function as novel tumor suppressor genes epigenetically silenced in medulloblastoma.
    Autorzy:
    Kongkham PN; Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Centre, Toronto, Ontario, Canada M5G 1X8.
    Northcott PA
    Croul SE
    Smith CA
    Taylor MD
    Rutka JT
    Pokaż więcej
    Źródło:
    Oncogene [Oncogene] 2010 May 20; Vol. 29 (20), pp. 3017-24. Date of Electronic Publication: 2010 Mar 08.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Gene Silencing*
    Genes, Tumor Suppressor/*physiology
    Glycoproteins/*genetics
    Intercellular Signaling Peptides and Proteins/*genetics
    Medulloblastoma/*genetics
    Membrane Proteins/*genetics
    Wnt Proteins/*metabolism
    Adaptor Proteins, Signal Transducing/antagonists & inhibitors ; Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Cell Line, Tumor ; Cerebellum/metabolism ; Cerebellum/pathology ; DNA Methylation ; Dishevelled Proteins ; Gene Expression Regulation, Neoplastic ; Glycoproteins/metabolism ; Humans ; Intercellular Signaling Peptides and Proteins/metabolism ; Intracellular Signaling Peptides and Proteins ; Medulloblastoma/metabolism ; Medulloblastoma/pathology ; Membrane Proteins/metabolism ; Mice ; Mice, Nude ; Phosphoproteins/antagonists & inhibitors ; Phosphoproteins/genetics ; Phosphoproteins/metabolism ; Phosphorylation ; Promoter Regions, Genetic ; Survival Rate ; Xenograft Model Antitumor Assays
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma.
    Autorzy:
    Northcott PA; Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada.
    Nakahara Y
    Wu X
    Feuk L
    Ellison DW
    Croul S
    Mack S
    Kongkham PN
    Peacock J
    Dubuc A
    Ra YS
    Zilberberg K
    McLeod J
    Scherer SW
    Sunil Rao J
    Eberhart CG
    Grajkowska W
    Gillespie Y
    Lach B
    Grundy R
    Pollack IF
    Hamilton RL
    Van Meter T
    Carlotti CG
    Boop F
    Bigner D
    Gilbertson RJ
    Rutka JT
    Taylor MD
    Pokaż więcej
    Źródło:
    Nature genetics [Nat Genet] 2009 Apr; Vol. 41 (4), pp. 465-72. Date of Electronic Publication: 2009 Mar 08.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Cerebellar Neoplasms/*genetics
    Medulloblastoma/*genetics
    Cerebellar Neoplasms/enzymology ; Gene Amplification ; Gene Deletion ; Genes, Tumor Suppressor ; Genome, Human ; Histone-Lysine N-Methyltransferase/genetics ; Histones/metabolism ; Humans ; Lysine/metabolism ; Medulloblastoma/enzymology ; Polymorphism, Single Nucleotide ; Protein Processing, Post-Translational/genetics ; Sequence Deletion
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
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