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Wyszukujesz frazę ""Notch"" wg kryterium: Temat


Tytuł :
Inhibition of the Notch signaling pathway attenuates progression of cell motility, metastasis, and epithelial-to-mesenchymal transition-like phenomena induced by low concentrations of cisplatin in osteosarcoma.
Autorzy :
Dai G; Department of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, Guangdong, China. Electronic address: .
Liu G; Department of Orthopedics, Jingzhou Central Hospital, Jingzhou, 434000, Hubei, China.
Zheng D; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China.
Song Q; Department of Trauma Surgery, Wuhan No. 1 Hospital, Wuhan, 430022, Hubei, China.
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2021 May 15; Vol. 899, pp. 174058. Date of Electronic Publication: 2021 Mar 21.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Bone Neoplasms/*drug therapy
Cell Movement/*drug effects
Cisplatin/*pharmacology
Diamines/*pharmacology
Epithelial-Mesenchymal Transition/*drug effects
Lung Neoplasms/*prevention & control
Osteosarcoma/*drug therapy
Receptors, Notch/*antagonists & inhibitors
Thiazoles/*pharmacology
Animals ; Bone Neoplasms/genetics ; Bone Neoplasms/metabolism ; Bone Neoplasms/pathology ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Lung Neoplasms/secondary ; Male ; Mice, Inbred BALB C ; Mice, Nude ; Neoplasm Invasiveness ; Osteosarcoma/genetics ; Osteosarcoma/metabolism ; Osteosarcoma/secondary ; Receptors, Notch/genetics ; Receptors, Notch/metabolism ; Signal Transduction ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Biophysics of Notch Signaling.
Autorzy :
Sprinzak D; George S. Wise Faculty of Life Sciences, School of Neurobiology, Biochemistry, and Biophysics, Tel Aviv University, Tel Aviv 69978, Israel; email: .
Blacklow SC; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts 02115, USA; email: .
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Źródło :
Annual review of biophysics [Annu Rev Biophys] 2021 May 06; Vol. 50, pp. 157-189. Date of Electronic Publication: 2021 Feb 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms :
Signal Transduction*
Receptors, Notch/*metabolism
Animals ; Biophysical Phenomena ; Cell Nucleus/metabolism ; Humans ; Receptors, Notch/chemistry ; Receptors, Notch/genetics
Czasopismo naukowe
Tytuł :
The interaction between miRNAs/lncRNAs and Notch pathway in human disorders.
Autorzy :
Ghafouri-Fard S; Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Glassy MC; Translational Neuro-Oncology Laboratory, San Diego (UCSD) Moores Cancer Center, University of California, CA, United States.
Abak A; Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Hussen BM; Pharmacognosy Department, College of Pharmacy, Hawler Medical University, Erbil, Iraq.
Niazi V; Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Taheri M; Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Jun; Vol. 138, pp. 111496. Date of Electronic Publication: 2021 Mar 17.
Typ publikacji :
Journal Article; Review
MeSH Terms :
MicroRNAs/*metabolism
Neoplasms/*metabolism
RNA, Long Noncoding/*metabolism
Receptors, Notch/*metabolism
Signal Transduction/*physiology
Humans ; MicroRNAs/genetics ; Neoplasms/genetics ; RNA, Long Noncoding/genetics ; Receptors, Notch/genetics
Czasopismo naukowe
Tytuł :
Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch signaling to determine NASH-induced fibrosis.
Autorzy :
Yu J; Department of Medicine, Columbia University, New York, NY 10032, USA.
Zhu C; Department of Medicine, Columbia University, New York, NY 10032, USA.
Wang X; Department of Medicine, Columbia University, New York, NY 10032, USA.
Kim K; Department of Medicine, Columbia University, New York, NY 10032, USA.
Bartolome A; Department of Medicine, Columbia University, New York, NY 10032, USA.
Dongiovanni P; General Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan 20122, Italy.
Yates KP; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Valenti L; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan 20122, Italy.; Translational Medicine, Department of Transfusion Medicine and Hematology, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan 20122, Italy.
Carrer M; Ionis Pharmaceuticals Inc., Carlsbad, CA 92010, USA.
Sadowski T; Sanofi-Aventis, Frankfurt 65926, Germany.
Qiang L; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.
Tabas I; Department of Medicine, Columbia University, New York, NY 10032, USA.; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.; Department of Physiology, Columbia University, New York, NY 10032, USA.
Lavine JE; Department of Pediatrics, Columbia University, New York, NY 10032, USA.
Pajvani UB; Department of Medicine, Columbia University, New York, NY 10032, USA. .
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Źródło :
Science translational medicine [Sci Transl Med] 2021 Jun 23; Vol. 13 (599).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Jagged-1 Protein*
Non-alcoholic Fatty Liver Disease*/pathology
Receptors, Notch*
Signal Transduction*
Toll-Like Receptor 4*/genetics
Animals ; Disease Models, Animal ; Hepatocytes/pathology ; Humans ; Liver/pathology ; Liver Cirrhosis/pathology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout
Czasopismo naukowe
Tytuł :
Current Views on the Roles of O -Glycosylation in Controlling Notch-Ligand Interactions.
Autorzy :
Saiki W; Department of Molecular Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan.
Ma C; Department of Molecular Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan.
Okajima T; Department of Molecular Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan.; Institute for Glyco-core Research (iGCORE), Nagoya University, Nagoya, Aichi 464-8601, Japan.
Takeuchi H; Department of Molecular Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan.; Institute for Glyco-core Research (iGCORE), Nagoya University, Nagoya, Aichi 464-8601, Japan.
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Źródło :
Biomolecules [Biomolecules] 2021 Feb 18; Vol. 11 (2). Date of Electronic Publication: 2021 Feb 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Receptors, Notch/*metabolism
Animals ; Glycosylation ; Humans ; Mass Spectrometry ; Protein Binding ; Receptors, Notch/genetics
Czasopismo naukowe
Tytuł :
Alcohol drinking inhibits NOTCH-PAX9 signaling in esophageal squamous epithelial cells.
Autorzy :
Shi M; Beijing Stomatological Hospital, Capital Medical University, Beijing, PR China.; Cancer Research Program, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC, USA.
Ren S; Beijing Stomatological Hospital, Capital Medical University, Beijing, PR China.; Cancer Research Program, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC, USA.
Chen H; Cancer Research Program, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC, USA.
Li J; Cancer Research Program, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC, USA.; Department of Thoracic Surgery, Ningxia Medical University General Hospital, Yinchuan, PR China.
Huang C; Cancer Research Program, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC, USA.
Li Y; Cancer Research Program, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC, USA.
Han Y; Department of Thoracic Surgery, Ningxia Medical University General Hospital, Yinchuan, PR China.
Li Y; Department of Thoracic Surgery, National Cancer Center, Cancer Hospital of Chinese Academy of Medical Sciences, Beijing, PR China.
Sun Z; Beijing Stomatological Hospital, Capital Medical University, Beijing, PR China.
Chen X; Cancer Research Program, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC, USA.; Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Xiong Z; Cancer Research Program, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC, USA.
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Źródło :
The Journal of pathology [J Pathol] 2021 Apr; Vol. 253 (4), pp. 384-395. Date of Electronic Publication: 2021 Jan 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Alcohol Drinking/*adverse effects
Esophageal Squamous Cell Carcinoma/*pathology
PAX9 Transcription Factor/*drug effects
Receptors, Notch/*drug effects
Squamous Cell Carcinoma of Head and Neck/*pathology
Animals ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Esophageal Squamous Cell Carcinoma/metabolism ; Ethanol/toxicity ; Humans ; Mice ; PAX9 Transcription Factor/metabolism ; Receptors, Notch/metabolism ; Signal Transduction/drug effects ; Squamous Cell Carcinoma of Head and Neck/metabolism
Czasopismo naukowe
Tytuł :
Exploring the mechanism of pancreatic cell fate decisions via cell-cell communication.
Autorzy :
Huang D; Department of Mathematics, Shanghai University, Shanghai 200444, China.
Wang R; Department of Mathematics, Shanghai University, Shanghai 200444, China.
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Źródło :
Mathematical biosciences and engineering : MBE [Math Biosci Eng] 2021 Mar 11; Vol. 18 (3), pp. 2401-2424.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Basic Helix-Loop-Helix Transcription Factors*
Receptors, Notch*
Cell Communication ; Cell Differentiation ; Pancreas
Czasopismo naukowe
Tytuł :
NOTCH pathway activation in infantile hemangiomas.
Autorzy :
Zhang H; Department of Otolaryngology and Head and Neck Surgery, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, Ark.
Wei T; Department of Otolaryngology and Head and Neck Surgery, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, Ark.
Johnson A; Department of Otolaryngology and Head and Neck Surgery, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, Ark.
Sun R; Department of Otolaryngology and Head and Neck Surgery, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, Ark.
Richter G; Department of Otolaryngology and Head and Neck Surgery, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, Ark.
Strub GM; Department of Otolaryngology and Head and Neck Surgery, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, Ark. Electronic address: .
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Źródło :
Journal of vascular surgery. Venous and lymphatic disorders [J Vasc Surg Venous Lymphat Disord] 2021 Mar; Vol. 9 (2), pp. 489-496. Date of Electronic Publication: 2020 Aug 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Proliferation*/drug effects
Neovascularization, Pathologic*
Hemangioma/*metabolism
Receptors, Notch/*metabolism
Adrenergic beta-Antagonists/therapeutic use ; Angiogenesis Inhibitors/therapeutic use ; Child, Preschool ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Female ; Hemangioma/genetics ; Hemangioma/pathology ; Hemangioma/therapy ; Humans ; Infant ; Infant, Newborn ; Ligands ; Male ; Propranolol/therapeutic use ; Receptors, Notch/genetics ; Retrospective Studies ; Signal Transduction ; Transcription Factors/genetics ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Genetic interactions regulate hypoxia tolerance conferred by activating Notch in excitatory amino acid transporter 1-positive glial cells in Drosophila melanogaster.
Autorzy :
Zhou D; Division of Respiratory Medicine, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA.
Stobdan T; Division of Respiratory Medicine, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA.
Visk D; Division of Respiratory Medicine, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA.
Xue J; Division of Respiratory Medicine, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA.
Haddad GG; Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093, USA.; Rady Children's Hospital, San Diego, CA 92123, USA.
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Źródło :
G3 (Bethesda, Md.) [G3 (Bethesda)] 2021 Feb 09; Vol. 11 (2).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Drosophila Proteins*/genetics
Drosophila melanogaster*/metabolism
Excitatory Amino Acid Transporter 1*
Hypoxia*
Receptors, Notch*
Animals ; Neuroglia/metabolism ; Phenotype
Czasopismo naukowe
Tytuł :
Preosteoblast-enriched lnc-Evf2 facilitates osteogenic differentiation by targeting Notch.
Autorzy :
Zhang Z; Department of Orthopedic Surgery, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin Medical University General Hospital, Tianjin 300070, China.; Department of Histology and Embryology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.
Qi H; Department of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin 300070, China.
Xia H; Department of Histology and Embryology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.
Liu Q; Department of Orthopedic Surgery, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin Medical University General Hospital, Tianjin 300070, China.
Ren Y; Department of Orthopedic Surgery, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin Medical University General Hospital, Tianjin 300070, China.
Zhang K; Department of Orthopedic Surgery, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin Medical University General Hospital, Tianjin 300070, China.
Xue Y; Department of Histology and Embryology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.
Hong W; Department of Orthopedic Surgery, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin Medical University General Hospital, Tianjin 300070, China.
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Źródło :
Acta biochimica et biophysica Sinica [Acta Biochim Biophys Sin (Shanghai)] 2021 Feb 04; Vol. 53 (2), pp. 179-188.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Differentiation*
Osteogenesis*
Osteoblasts/*metabolism
RNA, Long Noncoding/*metabolism
Receptors, Notch/*metabolism
Animals ; Cell Line ; Mice ; RNA, Long Noncoding/genetics ; Receptors, Notch/genetics
Czasopismo naukowe
Tytuł :
MicroRNA‑223‑induced inhibition of the FBXW7 gene affects the proliferation and apoptosis of colorectal cancer cells via the Notch and Akt/mTOR pathways.
Autorzy :
Liu Z; Department of Infectious Diseases, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China.
Ma T; Department of Infectious Diseases, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China.
Duan J; Department of Infectious Diseases, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China.
Liu X; Department of Infectious Diseases, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China.
Liu L; Department of Infectious Diseases, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2021 Feb; Vol. 23 (2). Date of Electronic Publication: 2020 Dec 23.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
Cell Proliferation*
Signal Transduction*
F-Box-WD Repeat-Containing Protein 7/*metabolism
MicroRNAs/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
RNA, Neoplasm/*metabolism
Receptors, Notch/*metabolism
TOR Serine-Threonine Kinases/*metabolism
F-Box-WD Repeat-Containing Protein 7/genetics ; Female ; HCT116 Cells ; Humans ; Male ; MicroRNAs/genetics ; Proto-Oncogene Proteins c-akt/genetics ; RNA, Neoplasm/genetics ; Receptors, Notch/genetics ; TOR Serine-Threonine Kinases/genetics
Czasopismo naukowe
Tytuł :
JAGGED1 stimulates cranial neural crest cell osteoblast commitment pathways and bone regeneration independent of canonical NOTCH signaling.
Autorzy :
Kamalakar A; Department of Otolaryngology, USA. Electronic address: .
McKinney JM; Wallace H. Coulter Department of Biomedical Engineering, USA; George W. Woodruff School of Mechanical Engineering, Georgia Tech College of Engineering, Atlanta, GA, USA; The Atlanta Veterans Affairs Medical Center Atlanta, GA, USA. Electronic address: .
Salinas Duron D; Department of Computer Science, Westminster College, Salt Lake City, UT, USA. Electronic address: .
Amanso AM; Department of Otolaryngology, USA. Electronic address: .
Ballestas SA; Department of Otolaryngology, USA. Electronic address: .
Drissi H; Department of Cell Biology, USA; Department of Orthopaedics, Emory University, Atlanta, GA, USA; The Atlanta Veterans Affairs Medical Center Atlanta, GA, USA. Electronic address: .
Willett NJ; Department of Orthopaedics, Emory University, Atlanta, GA, USA; The Atlanta Veterans Affairs Medical Center Atlanta, GA, USA. Electronic address: .
Bhattaram P; Department of Cell Biology, USA; Department of Orthopaedics, Emory University, Atlanta, GA, USA. Electronic address: .
García AJ; Parker H. Petit Institute for Bioengineering and Biosciences, USA; George W. Woodruff School of Mechanical Engineering, Georgia Tech College of Engineering, Atlanta, GA, USA. Electronic address: .
Wood LB; George W. Woodruff School of Mechanical Engineering, Georgia Tech College of Engineering, Atlanta, GA, USA. Electronic address: .
Goudy SL; Department of Otolaryngology, USA; Department of Pediatric Otolaryngology, Children's Healthcare of Atlanta, Atlanta, GA, USA. Electronic address: .
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Źródło :
Bone [Bone] 2021 Feb; Vol. 143, pp. 115657. Date of Electronic Publication: 2020 Sep 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Neural Crest*/metabolism
Receptors, Notch*/metabolism
Adult ; Animals ; Bone Regeneration ; Child ; Humans ; Jagged-1 Protein/metabolism ; Mice ; Mice, Inbred C57BL ; Osteoblasts/metabolism ; Ubiquitin-Protein Ligases ; rho GTP-Binding Proteins
Czasopismo naukowe
Tytuł :
Notch in Head and Neck Cancer.
Autorzy :
Porcheri C; Institute of Oral Biology, Orofacial Development and Regeneration, University of Zurich, Zurich, Switzerland. .
Mitsiadis TA; Institute of Oral Biology, Orofacial Development and Regeneration, University of Zurich, Zurich, Switzerland.
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Źródło :
Advances in experimental medicine and biology [Adv Exp Med Biol] 2021; Vol. 1287, pp. 81-103.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Head and Neck Neoplasms*/metabolism
Head and Neck Neoplasms*/therapy
Receptors, Notch*
Humans ; Signal Transduction ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Notch Pathway: A Journey from Notching Phenotypes to Cancer Immunotherapy.
Autorzy :
Monticone G; Department of Genetics and Louisiana Cancer Research Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Miele L; Department of Genetics and Louisiana Cancer Research Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA. .
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Źródło :
Advances in experimental medicine and biology [Adv Exp Med Biol] 2021; Vol. 1287, pp. 201-222.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Immunotherapy*
Molecular Targeted Therapy*
Neoplasms/*therapy
Receptors, Notch/*antagonists & inhibitors
Humans ; Neoplasms/immunology ; Phenotype ; Receptors, Notch/metabolism
Czasopismo naukowe
Tytuł :
Active notch protects MAPK activated melanoma cell lines from MEK inhibitor cobimetinib.
Autorzy :
Porcelli L; Experimental Pharmacology Laboratory, Italia, 70124, Bari, Italy.
Mazzotta A; Experimental Pharmacology Laboratory, Italia, 70124, Bari, Italy.
Garofoli M; Experimental Pharmacology Laboratory, Italia, 70124, Bari, Italy.
Di Fonte R; Experimental Pharmacology Laboratory, Italia, 70124, Bari, Italy.
Guida G; Department of Basic Medical Sciences Neurosciences and Sense Organs, University of Bari, P.zza Giulio Cesare 11, 70124 Bari, Italy.
Guida M; Medical Oncology Unit, Italia, 70124, Bari, Italy.
Tommasi S; Molecular Diagnostics and Pharmacogenetics Unit IRCCS Istituto Tumori 'Giovanni Paolo II' di Bari, Italia, 70124, Bari, Italy.
Azzariti A; Experimental Pharmacology Laboratory, Italia, 70124, Bari, Italy. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Jan; Vol. 133, pp. 111006. Date of Electronic Publication: 2020 Nov 14.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Azetidines/*pharmacology
Melanoma/*drug therapy
Mitogen-Activated Protein Kinase Kinases/*antagonists & inhibitors
Mitogen-Activated Protein Kinases/*metabolism
Piperidines/*pharmacology
Protein Kinase Inhibitors/*pharmacology
Pyrazoles/*pharmacology
Quinolines/*pharmacology
Receptors, Notch/*antagonists & inhibitors
Skin Neoplasms/*drug therapy
Uveal Neoplasms/*drug therapy
Amyloid Precursor Protein Secretases/antagonists & inhibitors ; Amyloid Precursor Protein Secretases/metabolism ; Apoptosis/drug effects ; Cell Cycle Checkpoints/drug effects ; Cell Movement/drug effects ; Cellular Senescence/drug effects ; Enzyme Activation ; GTP-Binding Protein alpha Subunits, Gq-G11/genetics ; Hep G2 Cells ; Humans ; Melanoma/enzymology ; Melanoma/genetics ; Melanoma/pathology ; Mitogen-Activated Protein Kinase Kinases/metabolism ; Neoplasm Invasiveness ; Phosphorylation ; Proto-Oncogene Proteins B-raf/genetics ; Receptors, Notch/genetics ; Receptors, Notch/metabolism ; Signal Transduction ; Skin Neoplasms/enzymology ; Skin Neoplasms/genetics ; Skin Neoplasms/pathology ; Uveal Neoplasms/enzymology ; Uveal Neoplasms/genetics ; Uveal Neoplasms/pathology
SCR Disease Name :
Uveal melanoma
Czasopismo naukowe
Tytuł :
A Genome-Wide RNAi Screen for Enhancers of a Germline Tumor Phenotype Caused by Elevated GLP-1/Notch Signaling in Caenorhabditis elegans .
Autorzy :
Dalfó D; Skirball Institute of Biomolecular Medicine, Departments of Cell Biology and Pathology, NYU Grossman School of Medicine.
Ding Y; School of Medicine, Tongji University.
Liang Q; School of Medicine, Tongji University.
Fong A; Skirball Institute of Biomolecular Medicine, Departments of Cell Biology and Pathology, NYU Grossman School of Medicine.
Cipriani PG; Center for Genomics and Systems Biology, Department of Biology, New York University and Center for Genomics and Systems Biology, New York University Abu Dhabi.
Piano F; Center for Genomics and Systems Biology, Department of Biology, New York University and Center for Genomics and Systems Biology, New York University Abu Dhabi.
Zheng JC; School of Medicine, Tongji University.
Qin Z; School of Medicine, Tongji University .; Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopedic Department of Tongji Hospital, School of Medicine, Tongji University.
Hubbard EJA; Skirball Institute of Biomolecular Medicine, Departments of Cell Biology and Pathology, NYU Grossman School of Medicine .
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Źródło :
G3 (Bethesda, Md.) [G3 (Bethesda)] 2020 Dec 03; Vol. 10 (12), pp. 4323-4334. Date of Electronic Publication: 2020 Dec 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Caenorhabditis elegans*/genetics
Caenorhabditis elegans*/metabolism
Caenorhabditis elegans Proteins*/genetics
Caenorhabditis elegans Proteins*/metabolism
Neoplasms*
Receptors, Notch*/genetics
Receptors, Notch*/metabolism
Animals ; Germ Cells/metabolism ; Glucagon-Like Peptide 1 ; Phenotype ; RNA Interference
Czasopismo naukowe
Tytuł :
Membrane-Anchored Hairless Protein Restrains Notch Signaling Activity.
Autorzy :
Maier D; Deptartment of General Genetics 190g, University of Hohenheim, Garbenstr. 30, 70599 Stuttgart, Germany.
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Źródło :
Genes [Genes (Basel)] 2020 Nov 06; Vol. 11 (11). Date of Electronic Publication: 2020 Nov 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Drosophila Proteins/*metabolism
Receptors, Notch/*metabolism
Repressor Proteins/*metabolism
Transcription Factors/*metabolism
Animals ; Cell Membrane/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/physiology ; Drosophila melanogaster/metabolism ; Female ; Phenotype ; Protein Binding ; Receptors, Notch/genetics ; Receptors, Notch/physiology ; Repressor Proteins/genetics ; Signal Transduction/genetics ; Transcription Factors/genetics ; Transcription Factors/physiology
Czasopismo naukowe
Tytuł :
Targeting oncogenic Notch signaling with SERCA inhibitors.
Autorzy :
Pagliaro L; Department of Medicine and Surgery, University of Parma, 43126, Parma, Italy.
Marchesini M; Department of Medicine and Surgery, University of Parma, 43126, Parma, Italy.
Roti G; Department of Medicine and Surgery, University of Parma, 43126, Parma, Italy. .
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Źródło :
Journal of hematology & oncology [J Hematol Oncol] 2021 Jan 06; Vol. 14 (1), pp. 8. Date of Electronic Publication: 2021 Jan 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Enzyme Inhibitors/*therapeutic use
Neoplasms/*drug therapy
Receptors, Notch/*antagonists & inhibitors
Sarcoplasmic Reticulum Calcium-Transporting ATPases/*antagonists & inhibitors
Signal Transduction/*drug effects
Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Humans ; Molecular Targeted Therapy ; Neoplasms/metabolism ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/metabolism ; Receptors, Notch/metabolism ; Sarcoplasmic Reticulum Calcium-Transporting ATPases/metabolism ; Thapsigargin/analogs & derivatives ; Thapsigargin/pharmacology ; Thapsigargin/therapeutic use
Czasopismo naukowe
Tytuł :
Complex crosstalk of Notch and Hedgehog signalling during the development of the central nervous system.
Autorzy :
Jacobs CT; Department of Biochemistry and Molecular Biology, Cumming School of Medicine, Alberta Children's Hospital Research Institute, University of Calgary, 3330 Hospital Drive, Calgary, AB, T2N 4N1, Canada.
Huang P; Department of Biochemistry and Molecular Biology, Cumming School of Medicine, Alberta Children's Hospital Research Institute, University of Calgary, 3330 Hospital Drive, Calgary, AB, T2N 4N1, Canada. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Jan; Vol. 78 (2), pp. 635-644. Date of Electronic Publication: 2020 Sep 03.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Signal Transduction*
Central Nervous System/*growth & development
Hedgehog Proteins/*metabolism
Receptors, Notch/*metabolism
Animals ; Central Nervous System/embryology ; Central Nervous System/metabolism ; Gene Expression Regulation, Developmental ; Hedgehog Proteins/genetics ; Humans ; Receptors, Notch/genetics ; Transcriptional Activation
Czasopismo naukowe
Tytuł :
Notch receptor GLP-1 regulates toxicity of simulated microgravity stress by activating germline-intestine communication of insulin signaling in C. elegans.
Autorzy :
Liu H; Medical School, Southeast University, Nanjing, 210009, China.
Tian L; Medical School, Southeast University, Nanjing, 210009, China.
Wang D; Medical School, Southeast University, Nanjing, 210009, China. Electronic address: .
Pokaż więcej
Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Jan 01; Vol. 534, pp. 248-253. Date of Electronic Publication: 2020 Dec 03.
Typ publikacji :
Journal Article
MeSH Terms :
Weightlessness Simulation*
Caenorhabditis elegans/*metabolism
Caenorhabditis elegans Proteins/*physiology
Insulin/*physiology
Receptors, Notch/*physiology
Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans Proteins/antagonists & inhibitors ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/metabolism ; Germ Cells/metabolism ; Intestines ; Organ Specificity ; RNA Interference ; Receptors, Notch/antagonists & inhibitors ; Receptors, Notch/genetics ; Signal Transduction ; Stress, Physiological
Czasopismo naukowe

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