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Wyszukujesz frazę ""Nuclear Proteins"" wg kryterium: Temat


Tytuł:
The landscape of SETBP1 gene expression and transcription factor activity across human tissues.
Autorzy:
Whitlock JH; Department of Cell, Developmental and Integrative Biology, Heersink School of Medicine The University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
Wilk EJ; Department of Cell, Developmental and Integrative Biology, Heersink School of Medicine The University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
Howton TC; Department of Cell, Developmental and Integrative Biology, Heersink School of Medicine The University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
Clark AD; Department of Cell, Developmental and Integrative Biology, Heersink School of Medicine The University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
Lasseigne BN; Department of Cell, Developmental and Integrative Biology, Heersink School of Medicine The University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
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Źródło:
PloS one [PLoS One] 2024 Jan 02; Vol. 19 (1), pp. e0296328. Date of Electronic Publication: 2024 Jan 02 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Carrier Proteins*/genetics
Carrier Proteins*/metabolism
Nuclear Proteins*/genetics
Nuclear Proteins*/metabolism
Humans ; Abnormalities, Multiple/genetics ; Craniofacial Abnormalities/genetics ; Gene Expression ; Intellectual Disability/genetics ; Transcription Factors/genetics ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł:
NDP52 SUMOylation contributes to low-dose X-rays-induced cardiac hypertrophy through PINK1/Parkin-mediated mitophagy via MUL1/SUMO2 signalling.
Autorzy:
Gao A; Hengyang Medical School, Clinical Research Institute, The Second Affiliated Hospital, University of South China, Hengyang, Hunan, China.
Wang M; Hengyang Medical School, Clinical Research Institute, The Second Affiliated Hospital, University of South China, Hengyang, Hunan, China.
Tang X; Hengyang Medical School, Clinical Research Institute, The Second Affiliated Hospital, University of South China, Hengyang, Hunan, China.
Shi G; Hengyang Medical School, Clinical Research Institute, The Second Affiliated Hospital, University of South China, Hengyang, Hunan, China.; Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology, Hengyang Medical School, Cancer Research Institute, University of South China, Hengyang, Hunan, China.
Hou K; Hengyang Medical School, Clinical Research Institute, The Second Affiliated Hospital, University of South China, Hengyang, Hunan, China.
Fang J; Hengyang Medical School, Clinical Research Institute, The Second Affiliated Hospital, University of South China, Hengyang, Hunan, China.
Zhou L; Hengyang Medical School, Clinical Research Institute, The Second Affiliated Hospital, University of South China, Hengyang, Hunan, China.
Zhou H; Department of Radiology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Jiang W; Department of Cardiology, Zhuzhou Central Hospital, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, China.
Li Y; Department of Assisted Reproductive Centre, Zhuzhou Central Hospital, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, China.
Ouyang F; Department of Cardiology, Zhuzhou Central Hospital, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, China.
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Źródło:
Journal of cellular physiology [J Cell Physiol] 2024 Jan; Vol. 239 (1), pp. 79-96. Date of Electronic Publication: 2023 Nov 09.
Typ publikacji:
Journal Article
MeSH Terms:
Mitophagy*/genetics
Protein Kinases*/genetics
Protein Kinases*/metabolism
Nuclear Proteins*/genetics
Nuclear Proteins*/metabolism
Humans ; Cardiomegaly/genetics ; Chromatography, Liquid ; Lysine/metabolism ; Small Ubiquitin-Related Modifier Proteins/genetics ; Small Ubiquitin-Related Modifier Proteins/metabolism ; Sumoylation ; Tandem Mass Spectrometry ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; X-Rays
Czasopismo naukowe
Tytuł:
VCIP135 associates with both the N- and C-terminal regions of p97 ATPase.
Autorzy:
Nakayama S; Department of Molecular Cell Biology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Kondo H; Department of Molecular Cell Biology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2024 Jan; Vol. 300 (1), pp. 105540. Date of Electronic Publication: 2023 Dec 10.
Typ publikacji:
Journal Article
MeSH Terms:
Endopeptidases*/metabolism
Nuclear Proteins*/genetics
Nuclear Proteins*/metabolism
Adenosine Triphosphatases/genetics ; Adenosine Triphosphatases/metabolism ; Carrier Proteins/metabolism ; Cell Cycle Proteins/metabolism ; Protein Binding ; Valosin Containing Protein/genetics ; Valosin Containing Protein/metabolism ; HeLa Cells ; Humans
Czasopismo naukowe
Tytuł:
In silico study reveals unconventional interactions between MDC1 of DDR and Beclin-1 of autophagy.
Autorzy:
Pandya K; Department of Biotechnology and Bioengineering, Indian Institute of Advanced Research, Gandhinagar, India.
Singh N; Department of Biotechnology and Bioengineering, Indian Institute of Advanced Research, Gandhinagar, India. .
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Źródło:
Molecular diversity [Mol Divers] 2023 Dec; Vol. 27 (6), pp. 2789-2802. Date of Electronic Publication: 2022 Dec 08.
Typ publikacji:
Journal Article
MeSH Terms:
Nuclear Proteins*/chemistry
Nuclear Proteins*/genetics
Nuclear Proteins*/metabolism
Cell Cycle Proteins*
Beclin-1/metabolism ; Trans-Activators/chemistry ; Trans-Activators/genetics ; Trans-Activators/metabolism ; Adaptor Proteins, Signal Transducing/metabolism ; Molecular Docking Simulation ; Autophagy
Czasopismo naukowe
Tytuł:
Leishmania PNUTS discriminates between PP1 catalytic subunits through an RVxF-ΦΦ-F motif and polymorphisms in the PP1 C-tail and catalytic domain.
Autorzy:
Zhang Y; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA.
Sabatini R; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2023 Dec; Vol. 299 (12), pp. 105432. Date of Electronic Publication: 2023 Nov 04.
Typ publikacji:
Journal Article
MeSH Terms:
DNA-Binding Proteins*/chemistry
DNA-Binding Proteins*/genetics
DNA-Binding Proteins*/metabolism
Leishmania*/genetics
Leishmania*/metabolism
Nuclear Proteins*/chemistry
Nuclear Proteins*/genetics
Nuclear Proteins*/metabolism
Protein Phosphatase 1*/chemistry
Protein Phosphatase 1*/genetics
Protein Phosphatase 1*/metabolism
Animals ; Catalytic Domain ; Protein Binding ; Protein Isoforms/chemistry ; Protein Isoforms/genetics ; Protein Isoforms/metabolism
Czasopismo naukowe
Tytuł:
Development of Phenyl-substituted Isoindolinone- and Benzimidazole-type Cereblon Ligands for Targeted Protein Degradation.
Autorzy:
Nie X; Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Zhao Y; Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Tang H; Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Zhang Z; Department of Chemistry, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Liao J; Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Almodovar-Rivera CM; Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Sundaresan R; Department of Oncology, UW Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Xie H; Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Guo L; Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Wang B; Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Guan H; Department of Chemistry, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Xing Y; Department of Oncology, UW Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Tang W; Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, 53705, USA.; Department of Chemistry, University of Wisconsin-Madison, Madison, WI, 53705, USA.
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Źródło:
Chembiochem : a European journal of chemical biology [Chembiochem] 2024 Feb 16; Vol. 25 (4), pp. e202300685. Date of Electronic Publication: 2024 Jan 15.
Typ publikacji:
Journal Article
MeSH Terms:
Peptide Hydrolases*/metabolism
Nuclear Proteins*/metabolism
Phthalimides*
Proteolysis ; Transcription Factors/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Immunomodulating Agents ; Benzimidazoles ; Ligands
Czasopismo naukowe
Tytuł:
Broadening the phenotype and genotype spectrum of novel mutations in pontocerebellar hypoplasia with a comprehensive molecular literature review.
Autorzy:
Ghasemi MR; Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, , Tehran, Iran.; Center for Comprehensive Genetic Services, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Tehrani Fateh S; School of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Moeinafshar A; School of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Sadeghi H; Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, , Tehran, Iran.
Karimzadeh P; Pediatric Neurology Department, Mofid Children's Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mirfakhraie R; Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, , Tehran, Iran.
Rezaei M; Genomic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hashemi-Gorji F; Genomic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Rezvani Kashani M; Pediatric Neurology Department, Mofid Children's Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Fazeli Bavandpour F; Center for Comprehensive Genetic Services, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Bagheri S; Center for Comprehensive Genetic Services, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; School of Medicine, Islamic Azad University Tehran Medical Sciences, Tehran, Iran.
Moghimi P; Center for Comprehensive Genetic Services, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; School of Medicine, Islamic Azad University Tehran Medical Sciences, Tehran, Iran.
Rostami M; Center for Comprehensive Genetic Services, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Madannejad R; Center for Comprehensive Genetic Services, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Roudgari H; Center for Comprehensive Genetic Services, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Genomic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Miryounesi M; Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, , Tehran, Iran. .; Center for Comprehensive Genetic Services, Shahid Beheshti University of Medical Sciences, Tehran, Iran. .; Genomic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. .
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Źródło:
BMC medical genomics [BMC Med Genomics] 2024 Feb 13; Vol. 17 (1), pp. 51. Date of Electronic Publication: 2024 Feb 13.
Typ publikacji:
Journal Article
MeSH Terms:
Nuclear Proteins*
Cerebellar Diseases*
Female ; Pregnancy ; Humans ; Iran ; Genotype ; Phenotype ; Mutation
SCR Disease Name:
Pontocerebellar Hypoplasia
Czasopismo naukowe
Tytuł:
CDCA7-associated global aberrant DNA hypomethylation translates to localized, tissue-specific transcriptional responses.
Autorzy:
Vukic M; Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.
Chouaref J; Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.
Della Chiara V; Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.
Dogan S; Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.
Ratner F; Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.
Hogenboom JZM; Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.
Epp TA; Laboratory of Cell Differentiation, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.; CZ-OPENSCREEN, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Chawengsaksophak K; Laboratory of Cell Differentiation, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Vonk KKD; Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.
Breukel C; Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.
Ariyurek Y; Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.; Leiden Genome Technology Center, Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.
San Leon Granado D; Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.
Kloet SL; Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.; Leiden Genome Technology Center, Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.
Daxinger L; Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.
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Źródło:
Science advances [Sci Adv] 2024 Feb 09; Vol. 10 (6), pp. eadk3384. Date of Electronic Publication: 2024 Feb 09.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Cycle Proteins*/metabolism
Nuclear Proteins*/metabolism
DNA ; DNA Methylation ; Protein Isoforms/genetics ; Repressor Proteins/genetics ; Transcription Factors/genetics ; Animals ; Mice
Czasopismo naukowe
Tytuł:
DAXX promotes centromeric stability independently of ATRX by preventing the accumulation of R-loop-induced DNA double-stranded breaks.
Autorzy:
Pinto LM; DNA Repair and Chemoresistance Group, Department of Cancer Research, Luxembourg Institute of Health (LIH), L-1210 Luxembourg, Luxembourg.; Faculty of Science, Technology and Communication, University of Luxembourg, L-4365 Esch-sur-Alzette, Luxembourg.; Discovery & Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds LS2 9JT, UK.
Pailas A; DNA Repair and Chemoresistance Group, Department of Cancer Research, Luxembourg Institute of Health (LIH), L-1210 Luxembourg, Luxembourg.; Faculty of Science, Technology and Communication, University of Luxembourg, L-4365 Esch-sur-Alzette, Luxembourg.
Bondarchenko M; DNA Repair and Chemoresistance Group, Department of Cancer Research, Luxembourg Institute of Health (LIH), L-1210 Luxembourg, Luxembourg.; Faculty of Science, Technology and Communication, University of Luxembourg, L-4365 Esch-sur-Alzette, Luxembourg.
Sharma AB; DNA Repair and Chemoresistance Group, Department of Cancer Research, Luxembourg Institute of Health (LIH), L-1210 Luxembourg, Luxembourg.
Neumann K; DNA Repair and Chemoresistance Group, Department of Cancer Research, Luxembourg Institute of Health (LIH), L-1210 Luxembourg, Luxembourg.
Rizzo AJ; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Jeanty C; DNA Repair and Chemoresistance Group, Department of Cancer Research, Luxembourg Institute of Health (LIH), L-1210 Luxembourg, Luxembourg.
Nicot N; Translational Medicine Operations Hub, Luxembourg Institute of Health (LIH), Luxembourg, Luxembourg.
Racca C; Institut de Pharmacologie et Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III - Paul Sabatier (UT3), 31077 Toulouse Cedex 4, France.
Graham MK; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Naughton C; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh EH4 1QY, UK.
Liu Y; Institut Curie, PSL Research University, CNRS UMR3244, Dynamics of Genetic Information, Sorbonne Université, 75248 Paris Cedex 05, France.
Chen CL; Institut Curie, PSL Research University, CNRS UMR3244, Dynamics of Genetic Information, Sorbonne Université, 75248 Paris Cedex 05, France.
Meakin PJ; Discovery & Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds LS2 9JT, UK.
Gilbert N; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh EH4 1QY, UK.
Britton S; Institut de Pharmacologie et Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III - Paul Sabatier (UT3), 31077 Toulouse Cedex 4, France.
Meeker AK; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Heaphy CM; Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
Larminat F; Institut de Pharmacologie et Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III - Paul Sabatier (UT3), 31077 Toulouse Cedex 4, France.
Van Dyck E; DNA Repair and Chemoresistance Group, Department of Cancer Research, Luxembourg Institute of Health (LIH), L-1210 Luxembourg, Luxembourg.
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Źródło:
Nucleic acids research [Nucleic Acids Res] 2024 Feb 09; Vol. 52 (3), pp. 1136-1155.
Typ publikacji:
Journal Article
MeSH Terms:
Centromere*/metabolism
Molecular Chaperones*/genetics
Molecular Chaperones*/metabolism
Nuclear Proteins*/metabolism
R-Loop Structures*
X-linked Nuclear Protein*/genetics
X-linked Nuclear Protein*/metabolism
DNA Breaks, Double-Stranded*
Child ; Humans ; Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Chromatin ; Co-Repressor Proteins/metabolism ; DNA ; Histones/genetics ; Histones/metabolism ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł:
The third case of Marbach-Rustad progeroid syndrome caused by a de novo LEMD2 variant.
Autorzy:
Lu Z; Department of Genetics and Endocrinology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, China.
Zhang W; Department of Genetics and Endocrinology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, China.
Mao X; Department of Genetics and Endocrinology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, China.
Li D; Department of Genetics and Endocrinology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, China.
Chen X; Department of Genetics and Endocrinology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, China.
Liu L; Department of Genetics and Endocrinology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, China.
Lin Y; Department of Genetics and Endocrinology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, China.
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Źródło:
Clinical genetics [Clin Genet] 2024 Feb; Vol. 105 (2), pp. 209-213. Date of Electronic Publication: 2023 Oct 23.
Typ publikacji:
Journal Article
MeSH Terms:
Membrane Proteins*
Nuclear Proteins*
Humans ; China ; Exome Sequencing ; Heterozygote ; Mutation ; Phenotype ; Female ; Infant
Czasopismo naukowe
Tytuł:
ALYREF (Aly/REF export factor): A potential biomarker for predicting cancer occurrence and therapeutic efficacy.
Autorzy:
Zhao Y; Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Xing C; Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Peng H; Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; Hunan Key Laboratory of Tumor Models and Individualized Medicine, Changsha, Hunan 410011, China; Hunan Engineering Research Center of Cell Immunotherapy for Hematopoietic Malignancies, Changsha, Hunan 410011, China. Electronic address: .
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Źródło:
Life sciences [Life Sci] 2024 Feb 01; Vol. 338, pp. 122372. Date of Electronic Publication: 2023 Dec 21.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Nuclear Proteins*/metabolism
Neoplasms*/drug therapy
Neoplasms*/genetics
Animals ; Humans ; Transcription Factors/metabolism ; RNA Processing, Post-Transcriptional ; Biomarkers/metabolism ; AlkB Homolog 1, Histone H2a Dioxygenase/genetics ; AlkB Homolog 1, Histone H2a Dioxygenase/metabolism ; RNA-Binding Proteins/metabolism
Czasopismo naukowe
Tytuł:
The intrinsically disordered transcriptional activation domain of CIITA is functionally tuneable by single substitutions: An exception or a new paradigm?
Autorzy:
Sreenivasan S; Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Heffren P; Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Suh KS; Department of Chemistry, Kansas State University, Manhattan, Kansas, USA.
Rodnin MV; Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Kosa E; Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Fenton AW; Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Ladokhin AS; Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Smith PE; Department of Chemistry, Kansas State University, Manhattan, Kansas, USA.
Fontes JD; Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Swint-Kruse L; Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas, USA.
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Źródło:
Protein science : a publication of the Protein Society [Protein Sci] 2024 Feb; Vol. 33 (2), pp. e4863.
Typ publikacji:
Journal Article
MeSH Terms:
Nuclear Proteins*/metabolism
Transcriptional Activation*
Humans ; Amino Acid Substitution ; Intrinsically Disordered Proteins/chemistry ; Trans-Activators/chemistry
Czasopismo naukowe
Tytuł:
The crystal structure of SUN1-KASH6 reveals an asymmetric LINC complex architecture compatible with nuclear membrane insertion.
Autorzy:
Gurusaran M; Wellcome Centre for Cell Biology, Institute of Cell Biology, University of Edinburgh, Michael Swann Building, Max Born Crescent, Edinburgh, EH9 3BF, UK.
Erlandsen BS; Wellcome Centre for Cell Biology, Institute of Cell Biology, University of Edinburgh, Michael Swann Building, Max Born Crescent, Edinburgh, EH9 3BF, UK.
Davies OR; Wellcome Centre for Cell Biology, Institute of Cell Biology, University of Edinburgh, Michael Swann Building, Max Born Crescent, Edinburgh, EH9 3BF, UK. .
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Źródło:
Communications biology [Commun Biol] 2024 Jan 30; Vol. 7 (1), pp. 138. Date of Electronic Publication: 2024 Jan 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Nuclear Envelope*/metabolism
Nuclear Proteins*/metabolism
Membrane Proteins/metabolism ; Cytoskeleton/metabolism ; Cell Nucleus/metabolism
Czasopismo naukowe
Tytuł:
MDM4 was associated with poor prognosis and tumor-immune infiltration of cancers.
Autorzy:
Liu J; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.; Department of Endoscopy, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, China.; The Graduate School of Fujian Medical University, Fuzhou, China.
Yang J; Department of Endoscopy, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, China.; The Graduate School of Fujian Medical University, Fuzhou, China.
Pan Q; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
Wang X; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.; Department of Endoscopy, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, China.; The Graduate School of Fujian Medical University, Fuzhou, China.
Wang X; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
Chen H; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
Zheng X; Department of Endoscopy, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, China. .; The Graduate School of Fujian Medical University, Fuzhou, China. .
Huang Q; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China. .
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Źródło:
European journal of medical research [Eur J Med Res] 2024 Jan 27; Vol. 29 (1), pp. 79. Date of Electronic Publication: 2024 Jan 27.
Typ publikacji:
Journal Article
MeSH Terms:
Proto-Oncogene Proteins*/genetics
Proto-Oncogene Proteins*/metabolism
Nuclear Proteins*/genetics
Humans ; Cell Cycle Proteins/metabolism ; Carcinogenesis/genetics ; Prognosis ; Tumor Suppressor Protein p53/genetics
Czasopismo naukowe
Tytuł:
Small noncoding RNAs and sperm nuclear basic proteins reflect the environmental impact on germ cells.
Autorzy:
Ferrero G; Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, 10043, Orbassano, Turin, Italy.; Department of Computer Science, University of Turin, Corso Svizzera, 185, 10149, Turin, Italy.
Festa R; Department of Biology, University of Naples Federico II, Via Cinthia, 21, 80126, Naples, Italy.
Follia L; Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, 10043, Orbassano, Turin, Italy.
Lettieri G; Department of Biology, University of Naples Federico II, Via Cinthia, 21, 80126, Naples, Italy.
Tarallo S; Italian Institute for Genomic Medicine (IIGM), c/o IRCCS Candiolo, SP 142 Km. 3,95, 10060, Candiolo, Turin, Italy.
Notari T; Check-Up PolyDiagnostic and Research Laboratory, Andrology Unit, Viale Andrea De Luca 5, 84131, Salerno, Italy.
Giarra A; Department of Chemical Sciences, University of Naples Federico II, Via Cinthia, 21, 80126, Naples, Italy.
Marinaro C; Department of Biology, University of Naples Federico II, Via Cinthia, 21, 80126, Naples, Italy.
Pardini B; Italian Institute for Genomic Medicine (IIGM), c/o IRCCS Candiolo, SP 142 Km. 3,95, 10060, Candiolo, Turin, Italy.
Marano A; Department of Chemical Sciences, University of Naples Federico II, Via Cinthia, 21, 80126, Naples, Italy.
Piaggeschi G; Italian Institute for Genomic Medicine (IIGM), c/o IRCCS Candiolo, SP 142 Km. 3,95, 10060, Candiolo, Turin, Italy.
Di Battista C; Italian Institute for Genomic Medicine (IIGM), c/o IRCCS Candiolo, SP 142 Km. 3,95, 10060, Candiolo, Turin, Italy.
Trifuoggi M; Department of Chemical Sciences, University of Naples Federico II, Via Cinthia, 21, 80126, Naples, Italy.
Piscopo M; Department of Biology, University of Naples Federico II, Via Cinthia, 21, 80126, Naples, Italy. .
Montano L; Andrology Unit and Service of Lifestyle Medicine in UroAndrology, Local Health Authority (ASL) Salerno, Coordination Unit of the Network for Environmental and Reproductive Health (Eco-FoodFertility Project), S. Francesco di Assisi Hospital, 84020, Oliveto Citra, Salerno, Italy. .; PhD Program in Evolutionary Biology and Ecology, University of Rome Tor Vergata, 00133, Rome, Italy. .
Naccarati A; Italian Institute for Genomic Medicine (IIGM), c/o IRCCS Candiolo, SP 142 Km. 3,95, 10060, Candiolo, Turin, Italy.
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Źródło:
Molecular medicine (Cambridge, Mass.) [Mol Med] 2024 Jan 20; Vol. 30 (1), pp. 12. Date of Electronic Publication: 2024 Jan 20.
Typ publikacji:
Journal Article
MeSH Terms:
RNA, Small Untranslated*/genetics
RNA, Small Untranslated*/metabolism
Nuclear Proteins*
Male ; Humans ; Semen ; Sperm Motility ; Spermatozoa/metabolism ; Environment
Czasopismo naukowe
Tytuł:
Absence of the RING domain in MID1 results in patterning defects in the developing human brain.
Autorzy:
Frank S; Institute of Biochemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Gabassi E; Institute of Biochemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Käseberg S; Institute of Human Genetics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Bertin M; Institute of Human Genetics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Zografidou L; Institute of Human Genetics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Pfeiffer D; Institute of Human Genetics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Brennenstuhl H; Institute of Human Genetics, Heidelberg University, Heidelberg, Germany.
Falk S; Institute of Biochemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Karow M; Institute of Biochemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany .
Schweiger S; Institute of Human Genetics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
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Źródło:
Life science alliance [Life Sci Alliance] 2024 Jan 18; Vol. 7 (4). Date of Electronic Publication: 2024 Jan 18 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Esophagus*/abnormalities
Hypertelorism*
Hypospadias*
Induced Pluripotent Stem Cells*/metabolism
Nuclear Proteins*/genetics
Humans ; Brain/metabolism ; Microtubule Proteins/chemistry ; Transcription Factors/genetics ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism
SCR Disease Name:
Hypertelorism with esophageal abnormality and hypospadias
Czasopismo naukowe
Tytuł:
Kaposi's sarcoma herpesvirus latency-associated nuclear antigen broadly regulates viral gene expression and is essential for lytic infection.
Autorzy:
Li S; Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.; Program in Virology, Harvard Medical School, Boston, Massachusetts, United States of America.
Wang M; Department of Computer Science, Purdue University, West Lafayette, Indiana.
Van Sciver N; Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.; Program in Virology, Harvard Medical School, Boston, Massachusetts, United States of America.
Szymula A; Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.; Program in Virology, Harvard Medical School, Boston, Massachusetts, United States of America.
Tumuluri VS; Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.; Program in Virology, Harvard Medical School, Boston, Massachusetts, United States of America.
George A; Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.; Program in Virology, Harvard Medical School, Boston, Massachusetts, United States of America.
Ramachandran A; Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.; Program in Virology, Harvard Medical School, Boston, Massachusetts, United States of America.
Raina K; Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.; Program in Virology, Harvard Medical School, Boston, Massachusetts, United States of America.
Costa CN; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, Lisboa, Portugal.; Universidade Católica Portuguesa, Católica Medical School, Católica Biomedical Research, Palma de Cima, Portugal.
Zhao B; Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.
Kazemian M; Department of Computer Science, Purdue University, West Lafayette, Indiana.; Department of Biochemistry, Purdue University, West Lafayette, Indiana.
Simas JP; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, Lisboa, Portugal.; Universidade Católica Portuguesa, Católica Medical School, Católica Biomedical Research, Palma de Cima, Portugal.
Kaye KM; Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.; Program in Virology, Harvard Medical School, Boston, Massachusetts, United States of America.; Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2024 Jan 17; Vol. 20 (1), pp. e1011907. Date of Electronic Publication: 2024 Jan 17 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Herpesvirus 8, Human*/physiology
Sarcoma, Kaposi*
Nuclear Proteins*
Humans ; Virus Latency/genetics ; Antigens, Viral/genetics ; Antigens, Viral/metabolism ; Gene Expression ; Gene Expression Regulation, Viral ; Virus Replication
Czasopismo naukowe
Tytuł:
Design and synthesis of dual BRD4/Src inhibitors for treatment of triple-negative breast cancer.
Autorzy:
Wang Y; School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen, 518055, China.
Huang A; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Chen L; School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen, 518055, China.
Sun F; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Zhao M; School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen, 518055, China.
Zhang M; School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen, 518055, China.
Xie Y; School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen, 518055, China.
Xu S; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Li M; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China. Electronic address: .
Hong L; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China. Electronic address: .
Li G; School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen, 518055, China. Electronic address: .
Wang R; School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen, 518055, China; Institute of Materia Medica and Research Unit of Peptide Science, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China. Electronic address: .
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2024 Jan 15; Vol. 264, pp. 116009. Date of Electronic Publication: 2023 Nov 29.
Typ publikacji:
Journal Article
MeSH Terms:
Nuclear Proteins*
Triple Negative Breast Neoplasms*/drug therapy
Triple Negative Breast Neoplasms*/pathology
Humans ; Animals ; Mice ; Dasatinib/pharmacology ; Cell Line, Tumor ; Transcription Factors ; Xenograft Model Antitumor Assays ; Cell Proliferation ; Bromodomain Containing Proteins ; Cell Cycle Proteins
Czasopismo naukowe
Tytuł:
Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3.
Autorzy:
Raux B; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
Buchan KA; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
Bennett J; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
Christott T; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
Dowling MS; Pfizer Worldwide Research and Development, Groton, CT 06340, USA.
Farnie G; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
Fedorov O; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
Gamble V; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
Gileadi C; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
Giroud C; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
Huber KVM; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
Korczynska M; Pfizer Worldwide Research and Development, Cambridge, MA 02139, USA.
Limberakis C; Pfizer Worldwide Research and Development, Groton, CT 06340, USA.
Narayanan A; Pfizer Worldwide Research and Development, Cambridge, MA 02139, USA.
Owen DR; Pfizer Worldwide Research and Development, Cambridge, MA 02139, USA.
Sáez LD; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
Stock IA; Pfizer Worldwide Research and Development, Groton, CT 06340, USA.
Londregan AT; Pfizer Worldwide Research and Development, Cambridge, MA 02139, USA. Electronic address: .
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Źródło:
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2024 Jan 15; Vol. 98, pp. 129546. Date of Electronic Publication: 2023 Nov 07.
Typ publikacji:
Journal Article
MeSH Terms:
Nuclear Proteins*/metabolism
Histones*/metabolism
Humans ; Protein Domains ; Drug Discovery ; Neoplasm Proteins/metabolism ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł:
NSD3 in Cancer: Unraveling Methyltransferase-Dependent and Isoform-Specific Functions.
Autorzy:
Nuñez Y; Biomedical Science Research Laboratory, Department of Basic Sciences, Faculty of Medicine, Universidad Católica de la Santísima Concepción, Concepción 4090541, Chile.; Biochemistry, Faculty of Pharmacy, Universidad de Concepción, Concepción 4070383, Chile.
Vera S; Biomedical Science Research Laboratory, Department of Basic Sciences, Faculty of Medicine, Universidad Católica de la Santísima Concepción, Concepción 4090541, Chile.
Baeza V; Biomedical Science Research Laboratory, Department of Basic Sciences, Faculty of Medicine, Universidad Católica de la Santísima Concepción, Concepción 4090541, Chile.
Gonzalez-Pecchi V; Biomedical Science Research Laboratory, Department of Basic Sciences, Faculty of Medicine, Universidad Católica de la Santísima Concepción, Concepción 4090541, Chile.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 12; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 12.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Histone-Lysine N-Methyltransferase*/metabolism
Nuclear Proteins*/metabolism
Neoplasms*/enzymology
Neoplasms*/pathology
Humans ; Male ; Carcinoma/enzymology ; Leukemia/enzymology ; Oncogenes ; Protein Isoforms/genetics
Czasopismo naukowe

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