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Wyszukujesz frazę ""Nucleoside Transport Proteins"" wg kryterium: Temat


Tytuł :
Toward a Molecular Basis of Cellular Nucleoside Transport in Humans.
Autorzy :
Wright NJ
Lee SY; Department of Biochemistry, Duke University Medical Center, 303 Research Drive, Durham, North Carolina 27710, United States.
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Źródło :
Chemical reviews [Chem Rev] 2021 May 12; Vol. 121 (9), pp. 5336-5358. Date of Electronic Publication: 2020 Nov 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Nucleoside Transport Proteins/*metabolism
Nucleosides/*metabolism
Biological Transport, Active ; Humans ; Models, Molecular ; Nucleoside Transport Proteins/chemistry ; Nucleosides/chemistry ; Protein Conformation ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Equilibrative Nucleoside Transporters Mediate the Import of Nicotinamide Riboside and Nicotinic Acid Riboside into Human Cells.
Autorzy :
Kropotov A; Institute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.
Kulikova V; Institute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.; Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg 194223, Russia.
Nerinovski K; Department of Nuclear Physics Research Methods, St. Petersburg State University, St. Petersburg 199034, Russia.
Yakimov A; Peter the Great St. Petersburg Polytechnic University, St. Petersburg 195251, Russia.
Svetlova M; Institute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.
Solovjeva L; Institute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.
Sudnitsyna J; Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg 194223, Russia.
Migaud ME; Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA.
Khodorkovskiy M; Institute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.; Peter the Great St. Petersburg Polytechnic University, St. Petersburg 195251, Russia.
Ziegler M; Department of Biomedicine, University of Bergen, 5020 Bergen, Norway.
Nikiforov A; Institute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jan 30; Vol. 22 (3). Date of Electronic Publication: 2021 Jan 30.
Typ publikacji :
Journal Article
MeSH Terms :
Equilibrative Nucleoside Transport Proteins/*metabolism
Membrane Transport Proteins/*metabolism
Niacinamide/*analogs & derivatives
Pyridinium Compounds/*metabolism
Ribonucleosides/*metabolism
Aging/metabolism ; Cytosol/metabolism ; Equilibrative Nucleoside Transport Proteins/genetics ; HEK293 Cells ; Humans ; Magnetic Resonance Spectroscopy ; Membrane Transport Proteins/analysis ; Membrane Transport Proteins/genetics ; Metabolomics ; NAD/analysis ; NAD/metabolism ; Niacinamide/analysis ; Niacinamide/metabolism ; Nicotinamide Mononucleotide/metabolism ; Phosphorylation/physiology ; Phosphotransferases (Alcohol Group Acceptor)/metabolism ; Pyridinium Compounds/analysis ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Ribonucleosides/analysis
Czasopismo naukowe
Tytuł :
H syndrome with a novel homozygous SLC29A3 mutation in two sisters.
Autorzy :
Demir D; Department of Dermatology, Health Science University Ümraniye Training and Research Hospital, Istanbul, Turkey.
Aktaş Karabay E; Department of Dermatology, Bahçeşehir University Faculty of Medicine, Istanbul, Turkey.
Sözeri B; Division of Pediatric Rheumatology, Health Science University Ümraniye Training and Research Hospital, Istanbul, Turkey.
Gürsoy F; Department of Pathology, Health Science University Ümraniye Training and Research Hospital, Istanbul, Turkey.
Akgün Doğan Ö; Division of Pediatric Genetics, Health Science University Ümraniye Training and Research Hospital, Istanbul, Turkey.
Topaktaş E; Department of Pediatrics, Health Science University Ümraniye Training and Research Hospital, Istanbul, Turkey.
Zindancı İ; Department of Dermatology, Health Science University Ümraniye Training and Research Hospital, Istanbul, Turkey.
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Źródło :
Pediatric dermatology [Pediatr Dermatol] 2020 Nov; Vol. 37 (6), pp. 1135-1138. Date of Electronic Publication: 2020 Aug 10.
Typ publikacji :
Case Reports
MeSH Terms :
Contracture*
Nucleoside Transport Proteins*/genetics
Homozygote ; Humans ; Mutation ; Syndrome
Raport
Tytuł :
Serotonin Transporter and Plasma Membrane Monoamine Transporter Are Necessary for the Antidepressant-Like Effects of Ketamine in Mice.
Autorzy :
Bowman MA; Department of Cellular and Integrative Physiology at University of Texas Health, San Antonio, TX 78229, USA.
Vitela M; Department of Cellular and Integrative Physiology at University of Texas Health, San Antonio, TX 78229, USA.
Clarke KM; Department of Cellular and Integrative Physiology at University of Texas Health, San Antonio, TX 78229, USA.; Department of Pharmacology at University of Texas Health, San Antonio, TX 78229, USA.
Koek W; Department of Pharmacology at University of Texas Health, San Antonio, TX 78229, USA.; Department of Psychiatry at University of Texas Health, San Antonio, TX 78229, USA.
Daws LC; Department of Cellular and Integrative Physiology at University of Texas Health, San Antonio, TX 78229, USA.; Department of Pharmacology at University of Texas Health, San Antonio, TX 78229, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Oct 14; Vol. 21 (20). Date of Electronic Publication: 2020 Oct 14.
Typ publikacji :
Journal Article
MeSH Terms :
Antidepressive Agents/*pharmacology
Equilibrative Nucleoside Transport Proteins/*metabolism
Ketamine/*pharmacology
Serotonin Plasma Membrane Transport Proteins/*metabolism
Animals ; CA3 Region, Hippocampal/drug effects ; CA3 Region, Hippocampal/metabolism ; Equilibrative Nucleoside Transport Proteins/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Nucleus Accumbens/drug effects ; Nucleus Accumbens/metabolism ; Serotonin/metabolism ; Serotonin Plasma Membrane Transport Proteins/genetics
Czasopismo naukowe
Tytuł :
Equilibrative nucleoside transporter 1 inhibition rescues energy dysfunction and pathology in a model of tauopathy.
Autorzy :
Chang, Ching-Pang (AUTHOR)
Chang, Ya-Gin (AUTHOR)
Chuang, Pei-Yun (AUTHOR)
Nguyen, Thi Ngoc Anh (AUTHOR)
Wu, Kuo-Chen (AUTHOR)
Chou, Fang-Yi (AUTHOR)
Cheng, Sin-Jhong (AUTHOR)
Chen, Hui-Mei (AUTHOR)
Jin, Lee-Way (AUTHOR)
Carvalho, Kevin (AUTHOR)
Huin, Vincent (AUTHOR)
Buée, Luc (AUTHOR)
Liao, Yung-Feng (AUTHOR)
Lin, Chun-Jung (AUTHOR)
Blum, David (AUTHOR)
Chern, Yijuang (AUTHOR)
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Źródło :
Acta Neuropathologica Communications. 6/22/2021, Vol. 9 Issue 1, p1-18. 18p.
Czasopismo naukowe
Tytuł :
HPLC reveals novel features of nucleoside and nucleobase homeostasis, nucleoside metabolism and nucleoside transport.
Autorzy :
Altaweraqi RA; Membrane Protein Disease Research Group, Department of Physiology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
Yao SYM; Membrane Protein Disease Research Group, Department of Physiology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
Smith KM; Membrane Protein Disease Research Group, Department of Physiology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
Cass CE; Membrane Protein Disease Research Group, Department of Oncology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
Young JD; Membrane Protein Disease Research Group, Department of Physiology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Biomembranes [Biochim Biophys Acta Biomembr] 2020 Jul 01; Vol. 1862 (7), pp. 183247. Date of Electronic Publication: 2020 Feb 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Homeostasis*
Nucleoside Transport Proteins/*genetics
Nucleosides/*chemistry
Adenosine/genetics ; Amino Acid Sequence/genetics ; Animals ; Biological Transport ; Chromatography, High Pressure Liquid ; Humans ; Mice ; Nucleoside Transport Proteins/chemistry ; Oocytes/chemistry ; Oocytes/metabolism ; Sodium/chemistry ; Uridine/genetics ; Xenopus laevis/genetics
Czasopismo naukowe
Tytuł :
Structural and Biomolecular Analyses of Borrelia burgdorferi BmpD Reveal a Substrate-Binding Protein of an ABC-Type Nucleoside Transporter Family.
Autorzy :
Cuellar J; Institute of Biomedicine, Faculty of Medicine, University of Turku, Turku, Finland .; Turku Doctoral Programme of Molecular Medicine, Faculty of Medicine, University of Turku, Turku, Finland.
Åstrand M; Structural Bioinformatics Laboratory, Biochemistry, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland.; National Doctoral Programme in Informational and Structural Biology, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland.
Elovaara H; Institute of Biomedicine, Faculty of Medicine, University of Turku, Turku, Finland.
Pietikäinen A; Institute of Biomedicine, Faculty of Medicine, University of Turku, Turku, Finland.
Sirén S; Laboratory of Synthetic Drug Chemistry, Institute of Biomedicine, University of Turku, Turku, Finland.; Biochemistry, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland.
Liljeblad A; Laboratory of Synthetic Drug Chemistry, Institute of Biomedicine, University of Turku, Turku, Finland.
Guédez G; Structural Bioinformatics Laboratory, Biochemistry, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland.
Salminen TA; Structural Bioinformatics Laboratory, Biochemistry, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland.
Hytönen J; Institute of Biomedicine, Faculty of Medicine, University of Turku, Turku, Finland.; Laboratory Division, Clinical Microbiology, Turku University Hospital, Turku, Finland.
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Źródło :
Infection and immunity [Infect Immun] 2020 Mar 23; Vol. 88 (4). Date of Electronic Publication: 2020 Mar 23 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Proteins/*chemistry
Bacterial Proteins/*metabolism
Borrelia burgdorferi Group/*enzymology
Nucleoside Transport Proteins/*chemistry
Nucleoside Transport Proteins/*metabolism
Purines/*metabolism
Animals ; Antibodies, Bacterial/blood ; Bacterial Proteins/immunology ; Biological Transport, Active ; Chromatography, Liquid ; Crystallography, X-Ray ; Humans ; Lyme Disease/immunology ; Lyme Disease/prevention & control ; Mass Spectrometry ; Mice ; Nucleoside Transport Proteins/immunology ; Protein Binding ; Protein Conformation
Czasopismo naukowe
Tytuł :
Rosai-Dorfman Disease and Exocrine Pancreatic Insufficiency in a Patient With a Germline SLC29A3 Mutation.
Autorzy :
Blatt J; Divisions of Pediatric Hematology Oncology.; The Lineberger Comprehensive Cancer Center.
Parekh P; UNC Rex Health, Hematopathology, The University of North Carolina at Chapel Hill, Chapel Hill.
Powell BC; Cancer Genetics.
Fedoriw Y; Hematopathology.; The Lineberger Comprehensive Cancer Center.
Reddy I; Raleigh Medical Group, Gastroenterology, Raleigh, NC.
Montgomery ND; Hematopathology.; The Lineberger Comprehensive Cancer Center.
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Źródło :
Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2021 Jul 01; Vol. 43 (5), pp. e689-e691.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Germ-Line Mutation*
Exocrine Pancreatic Insufficiency/*genetics
Histiocytosis, Sinus/*genetics
Nucleoside Transport Proteins/*genetics
Adult ; Exocrine Pancreatic Insufficiency/complications ; Histiocytosis, Sinus/complications ; Humans ; Male ; Young Adult
Czasopismo naukowe
Tytuł :
Patient with H syndrome, cardiogenic shock, multiorgan infiltration, and digital ischemia.
Autorzy :
Ventura-Espejo L; Paediatric Department, Hospital Universitario Son Espases, Carretera de Valldemosa, 79, 07120, Palma, Spain.
Gracia-Darder I; Dermatology Department, Hospital Universitario Son Espases, Palma, Spain.
Escribá-Bori S; Paediatric Department, Hospital Universitario Son Espases, Carretera de Valldemosa, 79, 07120, Palma, Spain.
Amador-González ER; Paediatric Radiology Department, Hospital Universitario Son Espases, Palma, Spain.
Martín-Santiago A; Dermatology Department, Hospital Universitario Son Espases, Palma, Spain.
Ramakers J; Paediatric Department, Hospital Universitario Son Espases, Carretera de Valldemosa, 79, 07120, Palma, Spain. .; Multidisciplinary Group for Research in Peadiatrics. Hospital Universitari Son Espases, Balearic Islands Health Research Institute (IdISBa), Carretera de Valldemossa, 79, 07120, Palma, Spain. .
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Źródło :
Pediatric rheumatology online journal [Pediatr Rheumatol Online J] 2021 Jun 30; Vol. 19 (1), pp. 104. Date of Electronic Publication: 2021 Jun 30.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Cardiomyopathy, Dilated/*physiopathology
Hereditary Autoinflammatory Diseases/*physiopathology
Ischemia/*physiopathology
Multiple Organ Failure/*physiopathology
Shock, Cardiogenic/*physiopathology
Antibodies, Monoclonal, Humanized/therapeutic use ; COVID-19 ; Cardiomyopathy, Dilated/diagnostic imaging ; Cardiomyopathy, Dilated/therapy ; Child ; Glucocorticoids/therapeutic use ; Hereditary Autoinflammatory Diseases/diagnosis ; Hereditary Autoinflammatory Diseases/genetics ; Hereditary Autoinflammatory Diseases/therapy ; Humans ; Ischemia/therapy ; Kidney Diseases/diagnostic imaging ; Kidney Diseases/physiopathology ; Kidney Diseases/therapy ; Liver Diseases/diagnostic imaging ; Liver Diseases/physiopathology ; Liver Diseases/therapy ; Lung Diseases/diagnostic imaging ; Lung Diseases/physiopathology ; Lung Diseases/therapy ; Lymphadenopathy/diagnostic imaging ; Lymphadenopathy/physiopathology ; Lymphadenopathy/therapy ; Male ; Methylprednisolone/therapeutic use ; Multiple Organ Failure/therapy ; Nucleoside Transport Proteins/genetics ; Pulse Therapy, Drug ; Respiration, Artificial ; SARS-CoV-2 ; Shock, Cardiogenic/therapy ; Splenic Diseases/diagnostic imaging ; Splenic Diseases/physiopathology ; Splenic Diseases/therapy ; Toes/blood supply ; Tomography, X-Ray Computed ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Expanding the phenotypic spectrum of TNFRSF11A-associated dysosteosclerosis: a case with intracranial extramedullary hematopoiesis.
Autorzy :
Xue JY; Laboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan.; Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Simsek-Kiper PO; Division of Pediatric Genetics, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Utine GE; Division of Pediatric Genetics, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Yan L; Department of Neurology, China-Japan Friendship Hospital, Beijing, People's Republic of China.
Wang Z; Laboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan.; Department of Medical Genetics, Institute of Basic Medical Sciences, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
Taskiran EZ; Department of Medical Genetics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Karaosmanoglu B; Department of Medical Genetics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Imren G; Department of Medical Genetics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Gocmen R; Department of Radiology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Nishimura G; Laboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan.
Matsumoto N; Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Miyake N; Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Ikegawa S; Laboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan. .
Guo L; Laboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan. .
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Źródło :
Journal of human genetics [J Hum Genet] 2021 Jun; Vol. 66 (6), pp. 607-611. Date of Electronic Publication: 2021 Jan 06.
Typ publikacji :
Journal Article
MeSH Terms :
Hematopoiesis/*genetics
Osteosclerosis/*genetics
Receptor Activator of Nuclear Factor-kappa B/*genetics
Bone Diseases ; Child ; Child, Preschool ; Female ; Genetic Association Studies ; Genetic Heterogeneity ; Homozygote ; Humans ; Infant ; Intellectual Disability ; Mutation/genetics ; Nucleoside Transport Proteins/genetics ; Osteopetrosis/genetics ; Osteopetrosis/pathology ; Osteosclerosis/diagnosis ; Osteosclerosis/pathology ; Phenotype ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/genetics ; Sclerosis
SCR Disease Name :
Dysosteosclerosis; Sclerosing bone dysplasia mental retardation
Czasopismo naukowe
Tytuł :
Multimodality imaging of constrictive pericarditis in H syndrome.
Autorzy :
Malakan Rad E; Department of Pediatric Cardiology, Children's Medical Center (Pediatric Center of Excellence), Tehran University of Medical Sciences, Tehran, Iran.
Yaghmaei B; Department of Pediatric Intensive Care, Children's Medical Center (Pediatric Center of Excellence), Tehran University of Medical Sciences, Tehran, Iran.
Ziaee V; Department of Pediatrics, Tehran University of Medical Science, Tehran, Iran.; Children's Medical Center, Pediatric Center of Excellence, Tehran, Iran.; Pediatric Rheumatology Research Group, Rheumatology Research Center, Tehran University of Medical Science, Tehran, Iran.
Beirami F; Department of Pediatric Intensive Care, Children's Medical Center (Pediatric Center of Excellence), Tehran University of Medical Sciences, Tehran, Iran.
Pouraliakbar H; Rajaie Cardiovascular Medical and Research Center, Niayesh Highway, Tehran, Iran.
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Źródło :
Echocardiography (Mount Kisco, N.Y.) [Echocardiography] 2021 Jun; Vol. 38 (6), pp. 1021-1032. Date of Electronic Publication: 2021 Apr 26.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Pericarditis, Constrictive*/diagnosis
Pericarditis, Constrictive*/diagnostic imaging
Adolescent ; Echocardiography ; Humans ; Magnetic Resonance Imaging ; Male ; Multimodal Imaging ; Nucleoside Transport Proteins ; Pericardium/diagnostic imaging
Czasopismo naukowe
Tytuł :
'H-syndrome': a multisystem genetic disorder with cutaneous clues.
Autorzy :
Mori KS; Department of Endocrinology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India .
Balachandran K; Department of Endocrinology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.
Asirvatham AR; Department of Endocrinology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.
Mahadevan S; Department of Endocrinology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.
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Źródło :
BMJ case reports [BMJ Case Rep] 2021 May 04; Vol. 14 (5). Date of Electronic Publication: 2021 May 04.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Contracture*
Hearing Loss, Sensorineural*/genetics
Histiocytosis*
Hypertrichosis*
Adult ; Humans ; Male ; Mutation ; Nucleoside Transport Proteins/genetics
Czasopismo naukowe
Tytuł :
Cell-surface SLC nucleoside transporters and purine levels modulate BRD4-dependent chromatin states.
Autorzy :
Li KC; CeMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Girardi E; CeMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Kartnig F; CeMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Grosche S; CeMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Pemovska T; CeMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Bigenzahn JW; CeMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
Goldmann U; CeMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Sedlyarov V; CeMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Bensimon A; CeMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Schick S; CeMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Lin JG; CeMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Gürtl B; CeMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Reil D; CeMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Klavins K; CeMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Kubicek S; CeMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Christian Doppler Laboratory for Chemical Epigenetics and Antiinfectives, CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Sdelci S; CeMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain.
Superti-Furga G; CeMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria. .; Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria. .
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Źródło :
Nature metabolism [Nat Metab] 2021 May; Vol. 3 (5), pp. 651-664. Date of Electronic Publication: 2021 May 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Cycle Proteins/*metabolism
Chromatin/*metabolism
Nucleoside Transport Proteins/*metabolism
Purines/*metabolism
Solute Carrier Proteins/*metabolism
Transcription Factors/*metabolism
Adenine/metabolism ; Biosynthetic Pathways ; Cell Cycle Proteins/antagonists & inhibitors ; Cell Line ; Chromatin/genetics ; DNA-Binding Proteins/metabolism ; Gene Expression Regulation ; Gene Knockdown Techniques ; Humans ; Membrane Transport Proteins ; Models, Biological ; Solute Carrier Proteins/genetics ; Transcription Factors/antagonists & inhibitors ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Current Progress on Equilibrative Nucleoside Transporter Function and Inhibitor Design.
Autorzy :
Rehan S; Institute of Biotechnology, University of Helsinki, Helsinki, Finland.; HiLIFE, University of Helsinki, Helsinki, Finland.
Shahid S; Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.
Salminen TA; Structural Bioinformatics Laboratory, Biochemistry, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland.
Jaakola VP; Chemical Biology & Therapeutics, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland.
Paavilainen VO; Institute of Biotechnology, University of Helsinki, Helsinki, Finland.; HiLIFE, University of Helsinki, Helsinki, Finland.
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Źródło :
SLAS discovery : advancing life sciences R & D [SLAS Discov] 2019 Dec; Vol. 24 (10), pp. 953-968. Date of Electronic Publication: 2019 Sep 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Design*
Drug Discovery*/methods
Equilibrative Nucleoside Transport Proteins/*chemistry
Amino Acid Sequence ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Equilibrative Nucleoside Transport Proteins/antagonists & inhibitors ; Equilibrative Nucleoside Transport Proteins/genetics ; Humans ; Ligands ; Molecular Structure ; Mutation ; Protein Binding ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness.
Autorzy :
Hulpia F; Laboratory for Medicinal Chemistry (Campus Heymans), Ghent University, Ottergemsesteenweg 460, 9000, Gent, Belgium.
Mabille D; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium.
Campagnaro GD; College of Medical, Veterinary and Life Sciences, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, G12 8TA, UK.
Schumann G; Institute of Cell Biology, University of Bern, Baltzerstrasse 4, 3012, Bern, Switzerland.
Maes L; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium.
Roditi I; Institute of Cell Biology, University of Bern, Baltzerstrasse 4, 3012, Bern, Switzerland.
Hofer A; Department of Medical Biochemistry and Biophysics, Umeå University, 901 87, Umeå, Sweden.
de Koning HP; College of Medical, Veterinary and Life Sciences, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, G12 8TA, UK.
Caljon G; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium.
Van Calenbergh S; Laboratory for Medicinal Chemistry (Campus Heymans), Ghent University, Ottergemsesteenweg 460, 9000, Gent, Belgium. .
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Źródło :
Nature communications [Nat Commun] 2019 Dec 05; Vol. 10 (1), pp. 5564. Date of Electronic Publication: 2019 Dec 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Deoxyadenosines/*pharmacology
Nucleoside Transport Proteins/*metabolism
Protozoan Proteins/*metabolism
Trypanosoma brucei brucei/*drug effects
Trypanosomiasis, African/*drug therapy
Tubercidin/*pharmacology
Animals ; Antimetabolites, Antineoplastic/chemistry ; Antimetabolites, Antineoplastic/pharmacology ; Cell Line ; Cell Survival ; Deoxyadenosines/chemistry ; Drug Therapy, Combination ; Female ; Humans ; Mice ; Molecular Structure ; Nucleoside Transport Proteins/genetics ; Protozoan Proteins/genetics ; Trypanocidal Agents/chemistry ; Trypanocidal Agents/pharmacology ; Trypanosoma brucei brucei/genetics ; Trypanosoma brucei brucei/physiology ; Trypanosomiasis, African/parasitology ; Tubercidin/chemistry
Czasopismo naukowe
Tytuł :
Serotonin uptake via plasma membrane monoamine transporter during myocardial ischemia-reperfusion in the rat heart in vivo.
Autorzy :
Sonobe T; Department of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan.
Akiyama T; Department of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan.
Du CK; Department of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan.
Pearson JT; Department of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan.
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Źródło :
Physiological reports [Physiol Rep] 2019 Nov; Vol. 7 (22), pp. e14297.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Equilibrative Nucleoside Transport Proteins/*metabolism
Myocardial Reperfusion Injury/*metabolism
Myocardium/*metabolism
Serotonin/*metabolism
Animals ; Equilibrative Nucleoside Transport Proteins/antagonists & inhibitors ; Hydroxyindoleacetic Acid/antagonists & inhibitors ; Hydroxyindoleacetic Acid/metabolism ; Male ; Microdialysis/methods ; Myocardial Reperfusion Injury/pathology ; Quinolines/pharmacology ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Bidirectional transport of 2-chloroadenosine by equilibrative nucleoside transporter 4 (hENT4): Evidence for allosteric kinetics at acidic pH.
Autorzy :
Tandio D; Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada.
Vilas G; Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada.
Hammond JR; Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada. .
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Źródło :
Scientific reports [Sci Rep] 2019 Sep 19; Vol. 9 (1), pp. 13555. Date of Electronic Publication: 2019 Sep 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
2-Chloroadenosine/*metabolism
Equilibrative Nucleoside Transport Proteins/*chemistry
Equilibrative Nucleoside Transport Proteins/*metabolism
Tritium/*chemistry
2-Chloroadenosine/chemistry ; Animals ; Biological Transport ; Cell Line ; Equilibrative Nucleoside Transport Proteins/genetics ; Humans ; Hydrogen-Ion Concentration ; Kinetics ; Swine ; Transfection
Czasopismo naukowe
Tytuł :
Facilitative lysosomal transport of bile acids alleviates ER stress in mouse hematopoietic precursors.
Autorzy :
Persaud AK; Division of Pharmaceutics & Pharmacology, College of Pharmacy, Ohio State University, Columbus, OH, 43210, USA.
Nair S; Division of Pharmaceutics & Pharmacology, College of Pharmacy, Ohio State University, Columbus, OH, 43210, USA.
Rahman MF; Division of Pharmaceutics & Pharmacology, College of Pharmacy, Ohio State University, Columbus, OH, 43210, USA.
Raj R; Division of Pharmaceutics & Pharmacology, College of Pharmacy, Ohio State University, Columbus, OH, 43210, USA.
Weadick B; Division of Pharmaceutics & Pharmacology, College of Pharmacy, Ohio State University, Columbus, OH, 43210, USA.
Nayak D; Division of Pharmaceutics & Pharmacology, College of Pharmacy, Ohio State University, Columbus, OH, 43210, USA.
McElroy C; Division of Pharmaceutics & Pharmacology, College of Pharmacy, Ohio State University, Columbus, OH, 43210, USA.
Shanmugam M; Division of Pharmaceutics & Pharmacology, College of Pharmacy, Ohio State University, Columbus, OH, 43210, USA.
Knoblaugh S; Depatment of Veterinary Biosciences, College of Veterinary Medicine, Ohio State University, Columbus, OH, 43210, USA.
Cheng X; Division of Medicinal Chemistry & Pharmacognosy, College of Pharmacy, Ohio State University, Columbus, OH, 43210, USA.
Govindarajan R; Division of Pharmaceutics & Pharmacology, College of Pharmacy, Ohio State University, Columbus, OH, 43210, USA. .; Translational Therapeutics, Ohio State University Comprehensive Cancer Center, Ohio State University, Columbus, OH, 43210, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 23; Vol. 12 (1), pp. 1248. Date of Electronic Publication: 2021 Feb 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Endoplasmic Reticulum Stress*
Bile Acids and Salts/*metabolism
Hematopoietic Stem Cells/*metabolism
Lysosomes/*metabolism
Animals ; Apoptosis/drug effects ; Bile Acids and Salts/blood ; Biological Transport/drug effects ; Bone Marrow Cells/metabolism ; Cell Differentiation/drug effects ; Cell Survival/drug effects ; Endoplasmic Reticulum/drug effects ; Endoplasmic Reticulum/metabolism ; Erythroid Cells/drug effects ; Erythroid Cells/metabolism ; Hematopoietic Stem Cell Transplantation ; Hydrogen-Ion Concentration ; Lysosomes/drug effects ; Metabolomics ; Mice ; Nucleoside Transport Proteins/metabolism ; Taurine/metabolism ; Taurochenodeoxycholic Acid/pharmacology
Czasopismo naukowe
Tytuł :
Yeast α-arrestin Art2 is the key regulator of ubiquitylation-dependent endocytosis of plasma membrane vitamin B1 transporters.
Autorzy :
Savocco J; Louvain Institute of Biomolecular Science and Technology, Université catholique de Louvain, Louvain-la-Neuve, Belgium.
Nootens S; Louvain Institute of Biomolecular Science and Technology, Université catholique de Louvain, Louvain-la-Neuve, Belgium.
Afokpa W; Louvain Institute of Biomolecular Science and Technology, Université catholique de Louvain, Louvain-la-Neuve, Belgium.
Bausart M; Louvain Institute of Biomolecular Science and Technology, Université catholique de Louvain, Louvain-la-Neuve, Belgium.
Chen X; Louvain Institute of Biomolecular Science and Technology, Université catholique de Louvain, Louvain-la-Neuve, Belgium.
Villers J; Louvain Institute of Biomolecular Science and Technology, Université catholique de Louvain, Louvain-la-Neuve, Belgium.
Renard HF; Louvain Institute of Biomolecular Science and Technology, Université catholique de Louvain, Louvain-la-Neuve, Belgium.
Prévost M; Structure and Function of Biological Membranes, Université libre de Bruxelles, Brussels, Belgium.
Wattiez R; Department of Proteomics and Microbiology, Research Institute for Biosciences, Université de Mons, Mons, Belgium.
Morsomme P; Louvain Institute of Biomolecular Science and Technology, Université catholique de Louvain, Louvain-la-Neuve, Belgium.
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Źródło :
PLoS biology [PLoS Biol] 2019 Oct 28; Vol. 17 (10), pp. e3000512. Date of Electronic Publication: 2019 Oct 28 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Processing, Post-Translational*
Arrestins/*genetics
Membrane Transport Proteins/*genetics
Nucleoside Transport Proteins/*genetics
Saccharomyces cerevisiae/*genetics
Saccharomyces cerevisiae Proteins/*genetics
Thiamine/*metabolism
Arrestins/metabolism ; Cell Membrane/drug effects ; Cell Membrane/genetics ; Cell Membrane/metabolism ; Cell Wall/drug effects ; Cell Wall/genetics ; Cell Wall/metabolism ; Endocytosis/genetics ; Endoplasmic Reticulum/drug effects ; Endoplasmic Reticulum/genetics ; Endoplasmic Reticulum/metabolism ; Endosomal Sorting Complexes Required for Transport/genetics ; Endosomal Sorting Complexes Required for Transport/metabolism ; Gene Expression Regulation, Fungal ; Membrane Transport Proteins/metabolism ; Models, Molecular ; Mutation ; Nucleoside Transport Proteins/metabolism ; Protein Binding ; Protein Kinases/genetics ; Protein Kinases/metabolism ; Protein Phosphatase 2/genetics ; Protein Phosphatase 2/metabolism ; Protein Structure, Secondary ; Proteomics/methods ; Saccharomyces cerevisiae/drug effects ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/metabolism ; Signal Transduction ; Thiamine/pharmacology ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Ubiquitin-Protein Ligase Complexes/genetics ; Ubiquitin-Protein Ligase Complexes/metabolism ; Ubiquitination
Czasopismo naukowe
Tytuł :
In vitro inhibition of human nucleoside transporters and uptake of azacitidine by an isocitrate dehydrogenase-2 inhibitor enasidenib and its metabolite AGI-16903.
Autorzy :
Tong Z; a Nonclinical Development , Celgene Corporation , Summit , NJ , USA.
Yerramilli U; a Nonclinical Development , Celgene Corporation , Summit , NJ , USA.
Yao S; b Department of Physiology, Membrane Protein Disease Research Group , University of Alberta , Edmonton , Canada.
Young JD; b Department of Physiology, Membrane Protein Disease Research Group , University of Alberta , Edmonton , Canada.
Hoffmann M; a Nonclinical Development , Celgene Corporation , Summit , NJ , USA.
Surapaneni S; a Nonclinical Development , Celgene Corporation , Summit , NJ , USA.
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Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2019 Oct; Vol. 49 (10), pp. 1229-1236. Date of Electronic Publication: 2018 Nov 29.
Typ publikacji :
Journal Article
MeSH Terms :
Aminopyridines*/pharmacokinetics
Aminopyridines*/pharmacology
Azacitidine*/pharmacokinetics
Azacitidine*/pharmacology
Triazines*/pharmacokinetics
Triazines*/pharmacology
Isocitrate Dehydrogenase/*antagonists & inhibitors
Nucleoside Transport Proteins/*metabolism
Animals ; Cell Line ; Humans ; Nucleoside Transport Proteins/genetics ; Xenopus laevis
Czasopismo naukowe

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