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Wyszukujesz frazę ""Nucleotides"" wg kryterium: Temat


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Tytuł :
siRNAs containing 2'-fluorinated Northern-methanocarbacyclic (2'-F-NMC) nucleotides: in vitro and in vivo RNAi activity and inability of mitochondrial polymerases to incorporate 2'-F-NMC NTPs.
Autorzy :
Akabane-Nakata M; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA.
Erande ND; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA.
Kumar P; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA.
Degaonkar R; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA.
Gilbert JA; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA.
Qin J; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA.
Mendez M; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA.
Woods LB; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA.
Jiang Y; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA.
Janas MM; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA.
O'Flaherty DK; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA.
Zlatev I; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA.
Schlegel MK; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA.
Matsuda S; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA.
Egli M; Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, TN 37232, USA.
Manoharan M; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Mar 18; Vol. 49 (5), pp. 2435-2449.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
RNA Interference*
Nucleotides/*chemistry
RNA, Small Interfering/*chemistry
Animals ; Argonaute Proteins/chemistry ; COS Cells ; Cells, Cultured ; Chlorocebus aethiops ; DNA Polymerase gamma/metabolism ; DNA-Directed RNA Polymerases/metabolism ; Mice ; Mitochondria/enzymology ; Mitochondrial Proteins/metabolism ; Models, Molecular ; Organophosphorus Compounds/chemical synthesis ; Organophosphorus Compounds/chemistry ; Prealbumin/genetics ; Pyrimidine Nucleotides/chemical synthesis ; Pyrimidine Nucleotides/chemistry ; Uridine/analogs & derivatives
Czasopismo naukowe
Tytuł :
Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide.
Autorzy :
Jamsen JA; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA.
Sassa A; Laboratory of Chromatin Metabolism and Epigenetics, Graduate School of Science, Chiba University, Chiba, Japan.
Shock DD; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA.
Beard WA; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA.
Wilson SH; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Apr 06; Vol. 12 (1), pp. 2059. Date of Electronic Publication: 2021 Apr 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
DNA Breaks, Double-Stranded*
DNA Repair*
DNA-Directed DNA Polymerase/*metabolism
Mutagenesis/*genetics
Nucleotides/*metabolism
Adenine/metabolism ; Base Pairing ; Biocatalysis ; Catalytic Domain ; Cytosine/metabolism ; Deoxyguanine Nucleotides/metabolism ; Humans ; Models, Molecular ; Mutagenesis, Insertional/genetics ; Oxidation-Reduction
Czasopismo naukowe
Tytuł :
Distinct kinetics for nucleotide hydrolysis in lymphocytes isolated from blood, spleen and cervical lymph nodes: Characterization of ectonucleotidase activity.
Autorzy :
Doleski PH; Department of Biochemistry and Molecular Biology, Universidade Federal de Santa Maria, Santa Maria, Brazil.
Cabral FL; Department of Microbiology and Parasitology, Universidade Federal de Santa Maria, Santa Maria, Brazil.
Adefegha SA; Department of Biochemistry and Molecular Biology, Universidade Federal de Santa Maria, Santa Maria, Brazil.; Department of Biochemistry, Federal University of Technology, Akure, Nigeria.
Jantsch MH; Department of Biochemistry and Molecular Biology, Universidade Federal de Santa Maria, Santa Maria, Brazil.
Ebone RS; Department of Biochemistry and Molecular Biology, Universidade Federal de Santa Maria, Santa Maria, Brazil.; Department of Microbiology and Parasitology, Universidade Federal de Santa Maria, Santa Maria, Brazil.
Leal DBR; Department of Biochemistry and Molecular Biology, Universidade Federal de Santa Maria, Santa Maria, Brazil.; Department of Microbiology and Parasitology, Universidade Federal de Santa Maria, Santa Maria, Brazil.
Schetinger MRC; Department of Biochemistry and Molecular Biology, Universidade Federal de Santa Maria, Santa Maria, Brazil.
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Źródło :
Cell biochemistry and function [Cell Biochem Funct] 2021 Jun; Vol. 39 (4), pp. 511-520. Date of Electronic Publication: 2021 Mar 29.
Typ publikacji :
Journal Article
MeSH Terms :
5'-Nucleotidase/*metabolism
Lymph Nodes/*chemistry
Lymphocytes/*chemistry
Nucleotides/*metabolism
Spleen/*chemistry
Adenosine Diphosphate/metabolism ; Adenosine Triphosphate/metabolism ; Animals ; Hydrolysis ; Kinetics ; Lymph Nodes/metabolism ; Lymphocytes/cytology ; Lymphocytes/metabolism ; Nucleotides/blood ; Nucleotides/isolation & purification ; Rats ; Rats, Wistar ; Spleen/metabolism
Czasopismo naukowe
Tytuł :
Refractoriness of STING therapy is relieved by AKT inhibitor through effective vascular disruption in tumour.
Autorzy :
Jeong SH; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
Yang MJ; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.; Center for Vascular Research, Institute for Basic Science, Daejeon, Republic of Korea.
Choi S; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.; Center for Vascular Research, Institute for Basic Science, Daejeon, Republic of Korea.
Kim J; Center for Vascular Research, Institute for Basic Science, Daejeon, Republic of Korea.
Koh GY; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea. .; Center for Vascular Research, Institute for Basic Science, Daejeon, Republic of Korea. .
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Źródło :
Nature communications [Nat Commun] 2021 Jul 20; Vol. 12 (1), pp. 4405. Date of Electronic Publication: 2021 Jul 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Membrane Proteins/*agonists
Neoplasms/*drug therapy
Nucleotides, Cyclic/*pharmacology
Proto-Oncogene Proteins c-akt/*antagonists & inhibitors
Animals ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Apoptosis/drug effects ; Apoptosis/immunology ; Cell Line, Tumor/transplantation ; Disease Models, Animal ; Drug Resistance, Neoplasm/drug effects ; Female ; Gene Knockdown Techniques ; Human Umbilical Vein Endothelial Cells ; Humans ; Immunity, Innate/drug effects ; Injections, Intralesional ; Male ; Membrane Proteins/antagonists & inhibitors ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice ; Mice, Transgenic ; Neoplasms/blood supply ; Neoplasms/immunology ; Neoplasms/pathology ; Nucleotides, Cyclic/therapeutic use ; Phosphorylation/drug effects ; Proto-Oncogene Proteins c-akt/metabolism ; Receptors, Tumor Necrosis Factor, Type I/metabolism ; Signal Transduction/drug effects ; Signal Transduction/immunology ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/immunology ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia.
Autorzy :
Di Marcantonio D; Blood Cell and Development Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Martinez E; Blood Cell and Development Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Kanefsky JS; Blood Cell and Development Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Huhn JM; Blood Cell and Development Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Gabbasov R; Blood Cell and Development Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Gupta A; Blood Cell and Development Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Krais JJ; Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Peri S; Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Tan Y; Blood Cell and Development Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Skorski T; Fels Cancer Institute for Personalized Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19140, USA.
Dorrance A; Division of Hematology/Oncology, Comprehensive Cancer Center, Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Garzon R; Division of Hematology/Oncology, Comprehensive Cancer Center, Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Goldman AR; Proteomics & Metabolomics Facility, Wistar Institute, Philadelphia, PA, USA.
Tang HY; Proteomics & Metabolomics Facility, Wistar Institute, Philadelphia, PA, USA.
Johnson N; Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Sykes SM; Blood Cell and Development Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA; Division of Hematology/Oncology, Department of Pediatrics, Washington University of Saint Louis, Saint Louis, MO 63110, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Jul 01; Vol. 81 (13), pp. 2752-2764.e6. Date of Electronic Publication: 2021 Jun 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Cycle*
Activating Transcription Factor 3/*metabolism
Leukemia, Myeloid, Acute/*metabolism
Neoplasm Proteins/*metabolism
Nucleotides/*metabolism
Serine/*metabolism
Activating Transcription Factor 3/genetics ; Cell Line, Tumor ; Humans ; Leukemia, Myeloid, Acute/genetics ; Neoplasm Proteins/genetics ; Nucleotides/genetics ; Serine/genetics
Czasopismo naukowe
Tytuł :
Assessing single-nucleotide polymorphism selection methods for the development of a low-density panel optimized for imputation in South African Drakensberger beef cattle.
Autorzy :
Lashmar SF; Department of Animal Sciences, University of Pretoria, Private Bag X20, Hatfield 0028, South Africa.
Berry DP; Department of Animal Sciences, University of Pretoria, Private Bag X20, Hatfield 0028, South Africa.; Animal and Grassland Research and Innovation Centre, Teagasc, Moorepark, Fermoy, Co. Cork, Ireland.
Pierneef R; Biotechnology Platform, Agricultural Research Council, Private Bag X5, Onderstepoort 0110, South Africa.
Muchadeyi FC; Biotechnology Platform, Agricultural Research Council, Private Bag X5, Onderstepoort 0110, South Africa.
Visser C; Department of Animal Sciences, University of Pretoria, Private Bag X20, Hatfield 0028, South Africa.
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Źródło :
Journal of animal science [J Anim Sci] 2021 Jul 01; Vol. 99 (7).
Typ publikacji :
Journal Article
MeSH Terms :
Nucleotides*
Polymorphism, Single Nucleotide*
Animals ; Cattle/genetics ; Gene Frequency ; Genotype ; Linkage Disequilibrium
Czasopismo naukowe
Tytuł :
The importance of chain context in assessing small nucleotide variants in titin: in silico case study of the I10-I11 tandem and its arrhythmic right ventricular cardiomyopathy linked position T2580.
Autorzy :
Fleming JR; Department of Biology, University of Konstanz, Konstanz, Germany.
Rigden DJ; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Mayans O; Department of Biology, University of Konstanz, Konstanz, Germany.
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Źródło :
Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2021 Jul; Vol. 39 (10), pp. 3480-3490. Date of Electronic Publication: 2020 May 22.
Typ publikacji :
Journal Article
MeSH Terms :
Cardiomyopathies*
Connectin*/genetics
Nucleotides*
Computer Simulation ; Humans ; Muscle Proteins
Czasopismo naukowe
Tytuł :
ADACT: a tool for analysing (dis)similarity among nucleotide and protein sequences using minimal and relative absent words.
Autorzy :
Akon M; Department of CSE, BUET, Dhaka, Bangladesh.
Akon M; Department of CSE, RUET, Rajshahi, Bangladesh.
Kabir M; Department of CSE, BUET, Dhaka, Bangladesh.
Rahman MS; Department of CSE, BUET, Dhaka, Bangladesh.
Rahman MS; Department of CSE, BUET, Dhaka, Bangladesh.
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Źródło :
Bioinformatics (Oxford, England) [Bioinformatics] 2021 Jun 16; Vol. 37 (10), pp. 1468-1470.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Algorithms*
Nucleotides*
Phylogeny ; Sequence Alignment ; Sequence Analysis, DNA ; Software
Czasopismo naukowe
Tytuł :
Characterization of the novel HLA-A*26:01:66 allele by sequencing-based typing.
Autorzy :
Blandin L; Histocompatibility and Immunogenetics laboratory, Clermont-Ferrand University Hospital, Clermont-Ferrand, France.
Visentin J; CHU de Bordeaux, Laboratoire d'Immunologie et Immunogénétique, Hôpital Pellegrin, Bordeaux, France.; University of Bordeaux, CNRS, ImmunoConcEpT, Bordeaux, France.
Cargou M; CHU de Bordeaux, Laboratoire d'Immunologie et Immunogénétique, Hôpital Pellegrin, Bordeaux, France.; University of Bordeaux, CNRS, ImmunoConcEpT, Bordeaux, France.
Lemal R; Histocompatibility and Immunogenetics laboratory, Clermont-Ferrand University Hospital, Clermont-Ferrand, France.; Clermont-Auvergne University, EA7453 CHELTER, Clermont-Ferrand, France.
Rouzaire P; Histocompatibility and Immunogenetics laboratory, Clermont-Ferrand University Hospital, Clermont-Ferrand, France.; Clermont-Auvergne University, EA7453 CHELTER, Clermont-Ferrand, France.
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Źródło :
HLA [HLA] 2021 Jun; Vol. 97 (6), pp. 532-533. Date of Electronic Publication: 2021 Mar 01.
Typ publikacji :
Journal Article
MeSH Terms :
HLA-A Antigens*/genetics
Nucleotides*
Alleles ; Codon ; Exons/genetics ; Histocompatibility Testing ; Humans ; Sequence Analysis, DNA
Czasopismo naukowe
Tytuł :
Syntheses of Morpholine-Based Nucleotide Analogs for Hepatic siRNA Targeting and Stabilization.
Autorzy :
Hofmeister A; Sanofi R&D, Industrial Park Hoechst, G838, Frankfurt am Main 65926, Germany.
Jahn-Hofmann K; Sanofi R&D, Industrial Park Hoechst, G838, Frankfurt am Main 65926, Germany.
Brunner B; Sanofi R&D, Industrial Park Hoechst, G838, Frankfurt am Main 65926, Germany.
Helms MW; Sanofi R&D, Industrial Park Hoechst, G838, Frankfurt am Main 65926, Germany.
Metz-Weidmann C; Sanofi R&D, Industrial Park Hoechst, G838, Frankfurt am Main 65926, Germany.
Krack A; Sanofi R&D, Industrial Park Hoechst, G838, Frankfurt am Main 65926, Germany.
Kurz M; Sanofi R&D, Industrial Park Hoechst, G838, Frankfurt am Main 65926, Germany.
Li Z; Sanofi R&D, Industrial Park Hoechst, G838, Frankfurt am Main 65926, Germany.
Weitzenberg MM; Institute of Organic Chemistry, Center of Biomolecular Drug Research (BMWZ), Leibniz University Hannover, Hannover 30167, Germany.; Helmholtz Zentrum München GmbH, German Research Center for Environmental Health, Institute of Medicinal Chemistry (IMC), Neuherberg 85764, Germany.
Pflimlin E; Hospices Civils de Lyon, Lyon 69002, France.
Plettenburg O; Institute of Organic Chemistry, Center of Biomolecular Drug Research (BMWZ), Leibniz University Hannover, Hannover 30167, Germany.; Helmholtz Zentrum München GmbH, German Research Center for Environmental Health, Institute of Medicinal Chemistry (IMC), Neuherberg 85764, Germany.
Scheidler S; Sanofi R&D, Industrial Park Hoechst, G838, Frankfurt am Main 65926, Germany.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 May 27; Vol. 64 (10), pp. 6838-6855. Date of Electronic Publication: 2021 May 05.
Typ publikacji :
Journal Article
MeSH Terms :
Morpholines/*chemistry
Nucleotides/*chemistry
RNA, Small Interfering/*metabolism
Acetylgalactosamine/chemistry ; Animals ; Cells, Cultured ; Female ; Hepatocytes/cytology ; Hepatocytes/metabolism ; Ligands ; Mice ; Mice, Inbred C57BL ; Nucleotides/chemical synthesis ; Nucleotides/metabolism ; Prealbumin/antagonists & inhibitors ; Prealbumin/genetics ; Prealbumin/metabolism ; RNA Interference ; RNA Stability ; RNA, Small Interfering/chemistry
Czasopismo naukowe
Tytuł :
Identification of Novel Carbocyclic Pyrimidine Cyclic Dinucleotide STING Agonists for Antitumor Immunotherapy Using Systemic Intravenous Route.
Autorzy :
Vyskocil S
Cardin D
Ciavarri J
Conlon J
Cullis C
England D
Gershman R
Gigstad K
Gipson K
Gould A
Greenspan P
Griffin R
Gulavita N
Harrison S
Hu Z
Hu Y
Hata A
Huang J
Huang SC
Janowick D
Jones M
Kolev V
Langston SP
Lee HM
Li G
Lok D
Ma L
Mai D
Malley J
Matsuda A
Mizutani H
Mizutani M
Molchanova N
Nunes E
Pusalkar S
Renou C
Rowland S
Sato Y
Shaw M
Shen L
Shi Z
Skene R; Drug Discovery Sciences, Takeda Pharmaceuticals International Company, 9625 Towne Centre Drive, San Diego, California 92121, United States.
Soucy F
Stroud S
Xu H
Xu T
Abu-Yousif AO
Zhang J
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 May 27; Vol. 64 (10), pp. 6902-6923. Date of Electronic Publication: 2021 May 17.
Typ publikacji :
Journal Article
MeSH Terms :
Membrane Proteins/*agonists
Nucleotides, Cyclic/*chemistry
Pyrimidines/*chemistry
Administration, Intravenous ; Animals ; Binding Sites ; Cell Line, Tumor ; Half-Life ; Humans ; Immunotherapy ; Membrane Proteins/metabolism ; Mice ; Molecular Docking Simulation ; Neoplasms/pathology ; Neoplasms/therapy ; Nucleotides, Cyclic/metabolism ; Nucleotides, Cyclic/therapeutic use ; Phosphates/chemistry ; Rats ; Structure-Activity Relationship ; Transplantation, Heterologous
Czasopismo naukowe
Tytuł :
Acetophenyl-thienyl-aniline-Linked Nucleotide for Construction of Solvatochromic Fluorescence Light-Up DNA Probes Sensing Protein-DNA Interactions.
Autorzy :
Güixens-Gallardo P; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nam. 2, 16000, Prague 6, Czech Republic.; Department of Organic Chemistry, Faculty of Science, Charles University in Prague, Hlavova 8, 12843, Prague 2, Czech Republic.
Hocek M; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nam. 2, 16000, Prague 6, Czech Republic.; Department of Organic Chemistry, Faculty of Science, Charles University in Prague, Hlavova 8, 12843, Prague 2, Czech Republic.
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Źródło :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2021 Apr 26; Vol. 27 (24), pp. 7090-7093. Date of Electronic Publication: 2021 Apr 08.
Typ publikacji :
Journal Article
MeSH Terms :
DNA*
Nucleotides*
Aniline Compounds ; DNA Probes ; Fluorescence ; Fluorescent Dyes
Czasopismo naukowe
Tytuł :
An original pronucleotide strategy for the simultaneous delivery of two bioactive drugs.
Autorzy :
Villard AL; UMR 5247 CNRS, Université Montpellier, ENSCM, Campus Triolet, place Eugène Bataillon, 34095, Montpellier, France.
Aubertin AM; Laboratoire de Virologie de la Faculté de Médecine, Unité 74 INSERM, Université L. Pasteur, 3, rue Koeberlé, 67000, Strasbourg, France.
Peyrottes S; UMR 5247 CNRS, Université Montpellier, ENSCM, Campus Triolet, place Eugène Bataillon, 34095, Montpellier, France.
Périgaud C; UMR 5247 CNRS, Université Montpellier, ENSCM, Campus Triolet, place Eugène Bataillon, 34095, Montpellier, France. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Apr 15; Vol. 216, pp. 113315. Date of Electronic Publication: 2021 Mar 03.
Typ publikacji :
Journal Article
MeSH Terms :
Nucleotides/*chemistry
Anti-HIV Agents/chemistry ; Anti-HIV Agents/metabolism ; Anti-HIV Agents/pharmacology ; Antiviral Agents/chemistry ; Antiviral Agents/metabolism ; Antiviral Agents/pharmacology ; Cell Line, Tumor ; Cell Survival/drug effects ; Drug Carriers/chemistry ; HIV-1/drug effects ; Humans ; Nucleotides/metabolism ; Nucleotides/pharmacology ; Prodrugs/chemistry ; Prodrugs/metabolism ; Prodrugs/pharmacology
Czasopismo naukowe
Tytuł :
Determination of adenine nucleotides by the modified method of high-performance liquid chromatography.
Autorzy :
Kalikova LB; Institute of Physiology of Komi Science Centre of the Ural Branch of the Russian Academy of Sciences, FCR Komi SC UB RAS.
Boyko ER; Institute of Physiology of Komi Science Centre of the Ural Branch of the Russian Academy of Sciences, FCR Komi SC UB RAS.
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Transliterated Title :
Определение адениновых нуклеотидов модифицированным методом высокоэффективной жидкостной хроматографии.
Źródło :
Klinicheskaia laboratornaia diagnostika [Klin Lab Diagn] 2021 Mar 30; Vol. 66 (3), pp. 172-176.
Typ publikacji :
Journal Article
MeSH Terms :
Adenine Nucleotides*
Adenosine Triphosphate*
Chromatography, High Pressure Liquid ; Indicators and Reagents
Czasopismo naukowe
Tytuł :
Detecting and phasing minor single-nucleotide variants from long-read sequencing data.
Autorzy :
Feng Z; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. .; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. .
Clemente JC; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Wong B; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Schadt EE; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Sema4, Stamford, CT, USA.
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Źródło :
Nature communications [Nat Commun] 2021 May 24; Vol. 12 (1), pp. 3032. Date of Electronic Publication: 2021 May 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Nucleotides*/isolation & purification
Computational Biology/*methods
Algorithms ; Bacteria ; Borrelia ; Borrelia burgdorferi ; Coinfection/diagnosis ; Genome, Human ; Haplotypes ; High-Throughput Nucleotide Sequencing ; Humans ; Metagenome ; Methylation ; Models, Statistical ; Nanopores
Czasopismo naukowe
Tytuł :
Three HLA-A alleles, A*11:01:89, A*11:01:96 and A*11:01:01:14 were identified in Chinese individuals.
Autorzy :
Dong L; HLA typing laboratory, Blood Center of Zhejiang Province, Hangzhou, Zhejiang Province, China.; Key Laboratory of Blood Safety Research, Hangzhou, Zhejiang Province, China.
Wang W; HLA typing laboratory, Blood Center of Zhejiang Province, Hangzhou, Zhejiang Province, China.; Key Laboratory of Blood Safety Research, Hangzhou, Zhejiang Province, China.
Zhang W; HLA typing laboratory, Blood Center of Zhejiang Province, Hangzhou, Zhejiang Province, China.; Key Laboratory of Blood Safety Research, Hangzhou, Zhejiang Province, China.
He J; HLA typing laboratory, Blood Center of Zhejiang Province, Hangzhou, Zhejiang Province, China.; Key Laboratory of Blood Safety Research, Hangzhou, Zhejiang Province, China.
Zhu F; HLA typing laboratory, Blood Center of Zhejiang Province, Hangzhou, Zhejiang Province, China.; Key Laboratory of Blood Safety Research, Hangzhou, Zhejiang Province, China.
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Źródło :
HLA [HLA] 2021 May; Vol. 97 (5), pp. 442-444. Date of Electronic Publication: 2021 Feb 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Asian Continental Ancestry Group*/genetics
Nucleotides*
Alleles ; Base Sequence ; China ; HLA-A Antigens/genetics ; Histocompatibility Testing ; Humans ; Polymorphism, Single Nucleotide ; Sequence Analysis, DNA
Czasopismo naukowe
Tytuł :
Prolonged activation of innate immune pathways by a polyvalent STING agonist.
Autorzy :
Li S; Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Luo M; Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Wang Z; Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Feng Q; Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Wilhelm J; Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Wang X; Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Li W; Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Wang J; Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Cholka A; Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Fu YX; Department of Pathology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Sumer BD; Department of Otolaryngology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Yu H; Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Zhejiang Provincial Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou, China.
Gao J; Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA. .; Department of Otolaryngology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA. .
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Źródło :
Nature biomedical engineering [Nat Biomed Eng] 2021 May; Vol. 5 (5), pp. 455-466. Date of Electronic Publication: 2021 Feb 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunity, Innate*
Membrane Proteins/*agonists
Neoplasms/*therapy
Nucleotides, Cyclic/*administration & dosage
Polymers/*administration & dosage
Animals ; CD8-Positive T-Lymphocytes/metabolism ; Female ; HEK293 Cells ; HeLa Cells ; Humans ; Lymph Nodes/drug effects ; Lymph Nodes/immunology ; Mice ; Neoplasms/immunology ; Nucleotides, Cyclic/pharmacology ; Polymers/pharmacology ; THP-1 Cells
Czasopismo naukowe
Tytuł :
Identification of a new HLA-A allele: A*31:187.
Autorzy :
Ingrassia F; Laboratorio Regionale di Tipizzazione Tessutale ed Immunologia dei Trapianti, U.O.C. Medicina Trasfusionale e dei Trapianti - P.O Cervello - A.O.R. Villa Sofia-Cervello, Palermo, Italy.
Pecoraro A; Laboratorio Regionale di Tipizzazione Tessutale ed Immunologia dei Trapianti, U.O.C. Medicina Trasfusionale e dei Trapianti - P.O Cervello - A.O.R. Villa Sofia-Cervello, Palermo, Italy.
Blando M; Laboratorio Regionale di Tipizzazione Tessutale ed Immunologia dei Trapianti, U.O.C. Medicina Trasfusionale e dei Trapianti - P.O Cervello - A.O.R. Villa Sofia-Cervello, Palermo, Italy.
Lo Brutto A; Laboratorio Regionale di Tipizzazione Tessutale ed Immunologia dei Trapianti, U.O.C. Medicina Trasfusionale e dei Trapianti - P.O Cervello - A.O.R. Villa Sofia-Cervello, Palermo, Italy.
Cappuzzo V; Laboratorio Regionale di Tipizzazione Tessutale ed Immunologia dei Trapianti, U.O.C. Medicina Trasfusionale e dei Trapianti - P.O Cervello - A.O.R. Villa Sofia-Cervello, Palermo, Italy.
Pokaż więcej
Źródło :
HLA [HLA] 2021 May; Vol. 97 (5), pp. 454-456. Date of Electronic Publication: 2021 Feb 22.
Typ publikacji :
Journal Article
MeSH Terms :
HLA-A Antigens*/genetics
Nucleotides*
Alleles ; Base Sequence ; Codon ; Humans ; Sequence Analysis, DNA
Czasopismo naukowe
Tytuł :
Moss enables high sensitivity single-nucleotide variant calling from multiple bulk DNA tumor samples.
Autorzy :
Zhang C; Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
El-Kebir M; Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana, IL, USA. .
Ochoa I; Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA. .; Department of Electrical Engineering, University of Navarra, Tecnun, San Sebastian, Spain. .
Pokaż więcej
Źródło :
Nature communications [Nat Commun] 2021 Apr 13; Vol. 12 (1), pp. 2204. Date of Electronic Publication: 2021 Apr 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Nucleotides*
DNA, Neoplasm/*genetics
Liver Neoplasms/*genetics
Algorithms ; Carcinoma, Hepatocellular ; Colorectal Neoplasms/genetics ; Gene Frequency ; Genomics/methods ; Humans ; Leukemia, Myeloid, Acute/genetics ; Mutation ; Polymorphism, Single Nucleotide
Czasopismo naukowe
Tytuł :
Epigenetic nucleotides enhance therapy.
Autorzy :
Kriaucionis S; Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK. .
Pokaż więcej
Źródło :
Science (New York, N.Y.) [Science] 2021 Apr 09; Vol. 372 (6538), pp. 127-128.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Biochemical Phenomena*
Nucleotides*/genetics
Epigenesis, Genetic ; Epigenomics ; Poly(ADP-ribose) Polymerase Inhibitors
Czasopismo naukowe

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