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Wyszukujesz frazę ""OPTIC nerve injuries"" wg kryterium: Temat


Tytuł:
Retinoic acid treatment recruits macrophages and increases axonal regeneration after optic nerve injury in the frog Rana pipiens.
Autorzy:
De La Rosa-Reyes V; Department of Anatomy and Neurobiology, University of Puerto Rico School of Medicine, San Juan, Puerto Rico, United States of America.; Institute of Neurobiology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico, United States of America.
Duprey-Díaz MV; Department of Anatomy and Neurobiology, University of Puerto Rico School of Medicine, San Juan, Puerto Rico, United States of America.
Blagburn JM; Institute of Neurobiology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico, United States of America.
Blanco RE; Department of Anatomy and Neurobiology, University of Puerto Rico School of Medicine, San Juan, Puerto Rico, United States of America.; Institute of Neurobiology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico, United States of America.
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Źródło:
PloS one [PLoS One] 2021 Nov 05; Vol. 16 (11), pp. e0255196. Date of Electronic Publication: 2021 Nov 05 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Macrophages/*drug effects
Nerve Regeneration/*drug effects
Optic Nerve Injuries/*drug therapy
Retinal Ganglion Cells/*drug effects
Tretinoin/*pharmacology
Animals ; Liposomes ; Optic Nerve Injuries/physiopathology ; Rana pipiens ; Retinal Ganglion Cells/physiology ; Tretinoin/therapeutic use
Czasopismo naukowe
Tytuł:
Overexpression of Reticulon 3 Enhances CNS Axon Regeneration and Functional Recovery after Traumatic Injury.
Autorzy:
Alhajlah S; Neuroscience and Ophthalmology, Institute of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, UK.; Applied Medical Science College, Shaqra University, P.O. Box 1678, Ad-Dawadmi 11911, Saudi Arabia.
Thompson AM; Neuroscience and Ophthalmology, Institute of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, UK.
Ahmed Z; Neuroscience and Ophthalmology, Institute of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, UK.; Centre for Trauma Sciences Research, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
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Źródło:
Cells [Cells] 2021 Aug 06; Vol. 10 (8). Date of Electronic Publication: 2021 Aug 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Nerve Regeneration*
Neuronal Outgrowth*
Axons/*metabolism
Carrier Proteins/*metabolism
Ganglia, Spinal/*metabolism
Optic Nerve Injuries/*metabolism
Retinal Ganglion Cells/*metabolism
Spinal Cord Injuries/*metabolism
Animals ; Axons/pathology ; Behavior, Animal ; Carrier Proteins/genetics ; Cells, Cultured ; Disease Models, Animal ; Female ; Ganglia, Spinal/pathology ; Motor Activity ; Optic Nerve Injuries/genetics ; Optic Nerve Injuries/pathology ; Optic Nerve Injuries/physiopathology ; Rats, Sprague-Dawley ; Retinal Ganglion Cells/pathology ; Signal Transduction ; Spinal Cord Injuries/genetics ; Spinal Cord Injuries/pathology ; Spinal Cord Injuries/physiopathology ; Up-Regulation ; Vesicular Transport Proteins/genetics ; Vesicular Transport Proteins/metabolism ; Rats
Czasopismo naukowe
Tytuł:
MMP2 Modulates Inflammatory Response during Axonal Regeneration in the Murine Visual System.
Autorzy:
Andries L; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, 3000 Leuven, Belgium.; Leuven Brain Institute, 3000 Leuven, Belgium.
Masin L; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, 3000 Leuven, Belgium.; Leuven Brain Institute, 3000 Leuven, Belgium.
Salinas-Navarro M; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, 3000 Leuven, Belgium.
Zaunz S; Department of Development and Regeneration, Stem Cell Institute, KU Leuven, 3000 Leuven, Belgium.
Claes M; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, 3000 Leuven, Belgium.; Leuven Brain Institute, 3000 Leuven, Belgium.
Bergmans S; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, 3000 Leuven, Belgium.; Leuven Brain Institute, 3000 Leuven, Belgium.
Brouwers V; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, 3000 Leuven, Belgium.
Lefevere E; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, 3000 Leuven, Belgium.
Verfaillie C; Department of Development and Regeneration, Stem Cell Institute, KU Leuven, 3000 Leuven, Belgium.
Movahedi K; Myeloid Cell Immunology Lab, VIB, Center for Inflammation Research, 1090 Brussels, Belgium.; Laboratory of Cellular and Molecular Immunology, Department of Biology, Vrije Universiteit Brussel, 1050 Brussels, Belgium.
De Groef L; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, 3000 Leuven, Belgium.; Leuven Brain Institute, 3000 Leuven, Belgium.
Moons L; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, 3000 Leuven, Belgium.; Leuven Brain Institute, 3000 Leuven, Belgium.
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Źródło:
Cells [Cells] 2021 Jul 02; Vol. 10 (7). Date of Electronic Publication: 2021 Jul 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Bone Marrow Transplantation*
Axons/*immunology
Matrix Metalloproteinase 2/*genetics
Nerve Regeneration/*immunology
Optic Nerve/*immunology
Optic Nerve Injuries/*immunology
Animals ; Antigens, Ly/genetics ; Antigens, Ly/immunology ; Axons/ultrastructure ; CX3C Chemokine Receptor 1/genetics ; CX3C Chemokine Receptor 1/immunology ; Cell Movement ; GAP-43 Protein/genetics ; GAP-43 Protein/immunology ; Gene Expression Regulation ; Immunity, Innate ; Inflammation ; Leukocyte Common Antigens/genetics ; Leukocyte Common Antigens/immunology ; Matrix Metalloproteinase 2/deficiency ; Matrix Metalloproteinase 2/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Myeloid Cells/cytology ; Myeloid Cells/immunology ; Nerve Regeneration/genetics ; Optic Nerve/metabolism ; Optic Nerve Injuries/genetics ; Optic Nerve Injuries/pathology ; Retina/immunology ; Retina/injuries ; Retina/metabolism ; Transplantation, Heterologous ; Whole-Body Irradiation
Czasopismo naukowe
Tytuł:
Topical ripasudil stimulates neuroprotection and axon regeneration in adult mice following optic nerve injury.
Autorzy:
Nishijima E; Visual Research Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, Japan.; Department of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan.
Namekata K; Visual Research Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, Japan. .
Kimura A; Visual Research Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, Japan.
Guo X; Visual Research Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, Japan.
Harada C; Visual Research Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, Japan.
Noro T; Visual Research Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, Japan.; Department of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan.
Nakano T; Department of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan.
Harada T; Visual Research Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2020 Sep 24; Vol. 10 (1), pp. 15709. Date of Electronic Publication: 2020 Sep 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Axons/*drug effects
Isoquinolines/*therapeutic use
Nerve Regeneration/*drug effects
Neuroprotective Agents/*therapeutic use
Optic Nerve Injuries/*drug therapy
Sulfonamides/*therapeutic use
Animals ; Axons/physiology ; Isoquinolines/administration & dosage ; MAP Kinase Signaling System/drug effects ; Mice ; Nerve Crush ; Nerve Regeneration/physiology ; Neuroprotective Agents/administration & dosage ; Optic Nerve Injuries/metabolism ; Optic Nerve Injuries/physiopathology ; Phosphorylation/drug effects ; Retinal Ganglion Cells/drug effects ; Retinal Ganglion Cells/metabolism ; Sulfonamides/administration & dosage
Czasopismo naukowe
Tytuł:
Tau Gene Deletion does not Influence Axonal Regeneration and Retinal Neuron Survival in the Injured Mouse Visual System.
Autorzy:
Rodriguez L; CUO-Recherche, Département d'ophtalmologie, Faculté de médecine, Université Laval and Centre de recherche du CHU de Québec-Université Laval, Quebec, QC G1V 0A6, Canada.
Joly S; CUO-Recherche, Département d'ophtalmologie, Faculté de médecine, Université Laval and Centre de recherche du CHU de Québec-Université Laval, Quebec, QC G1V 0A6, Canada.
Mdzomba JB; CUO-Recherche, Département d'ophtalmologie, Faculté de médecine, Université Laval and Centre de recherche du CHU de Québec-Université Laval, Quebec, QC G1V 0A6, Canada.
Pernet V; CUO-Recherche, Département d'ophtalmologie, Faculté de médecine, Université Laval and Centre de recherche du CHU de Québec-Université Laval, Quebec, QC G1V 0A6, Canada.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Jun 08; Vol. 21 (11). Date of Electronic Publication: 2020 Jun 08.
Typ publikacji:
Journal Article
MeSH Terms:
Gene Deletion*
Axons/*metabolism
Nerve Regeneration/*genetics
Optic Nerve Injuries/*genetics
Optic Nerve Injuries/*metabolism
Retinal Ganglion Cells/*pathology
tau Proteins/*genetics
Animals ; Cell Death ; Cell Survival ; Disease Models, Animal ; Disease Susceptibility ; Mice ; Mice, Knockout ; Optic Nerve Injuries/pathology ; Retina/metabolism ; Retina/pathology
Czasopismo naukowe
Tytuł:
Neuroinflammation and Optic Nerve Regeneration: Where Do We Stand in Elucidating Underlying Cellular and Molecular Players?
Autorzy:
Andries L; Department of Biology, Neural Circuit Development and Regeneration Research Group, KU Leuven, Leuven, Belgium.
De Groef L; Department of Biology, Neural Circuit Development and Regeneration Research Group, KU Leuven, Leuven, Belgium.
Moons L; Department of Biology, Neural Circuit Development and Regeneration Research Group, KU Leuven, Leuven, Belgium.
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Źródło:
Current eye research [Curr Eye Res] 2020 Mar; Vol. 45 (3), pp. 397-409. Date of Electronic Publication: 2019 Oct 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Axons/*physiology
Nerve Regeneration/*physiology
Optic Nerve/*physiopathology
Optic Nerve Injuries/*physiopathology
Animals ; Humans ; Optic Nerve/pathology ; Optic Nerve Injuries/metabolism ; Optic Nerve Injuries/pathology
Czasopismo naukowe
Tytuł:
Long-term neuronal survival, regeneration, and transient target reconnection after optic nerve crush and mesenchymal stem cell transplantation.
Autorzy:
Mesentier-Louro LA; Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-902, Brazil. .
Teixeira-Pinheiro LC; Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-902, Brazil.
Gubert F; Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-902, Brazil.
Vasques JF; Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-902, Brazil.; National Institute of Science and Technology for Regenerative Medicine-REGENERE, Rio de Janeiro, Brazil.
Silva-Junior AJ; Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-902, Brazil.; National Institute of Science and Technology for Regenerative Medicine-REGENERE, Rio de Janeiro, Brazil.
Chimeli-Ormonde L; Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-902, Brazil.; National Institute of Science and Technology for Regenerative Medicine-REGENERE, Rio de Janeiro, Brazil.
Nascimento-Dos-Santos G; Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-902, Brazil.
Mendez-Otero R; Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-902, Brazil.; National Institute of Science and Technology for Regenerative Medicine-REGENERE, Rio de Janeiro, Brazil.
Santiago MF; Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-902, Brazil.
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Źródło:
Stem cell research & therapy [Stem Cell Res Ther] 2019 Apr 17; Vol. 10 (1), pp. 121. Date of Electronic Publication: 2019 Apr 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mesenchymal Stem Cell Transplantation*
Nerve Regeneration*
Optic Nerve Injuries*/metabolism
Optic Nerve Injuries*/pathology
Optic Nerve Injuries*/therapy
Mesenchymal Stem Cells/*metabolism
Optic Nerve/*physiology
Allografts ; Animals ; Early Growth Response Protein 1/metabolism ; Female ; Male ; Mesenchymal Stem Cells/pathology ; Rats ; Retinal Ganglion Cells/metabolism ; Retinal Ganglion Cells/pathology
Czasopismo naukowe
Tytuł:
Genome-wide chromatin accessibility analyses provide a map for enhancing optic nerve regeneration.
Autorzy:
Pita-Thomas W; Department of Neuroscience, Washington University School of Medicine, St Louis, MO, 63110, USA.
Gonçalves TM; Department of Neuroscience, Washington University School of Medicine, St Louis, MO, 63110, USA.
Kumar A; Department of Neuroscience, Washington University School of Medicine, St Louis, MO, 63110, USA.
Zhao G; Department of Neuroscience, Washington University School of Medicine, St Louis, MO, 63110, USA. .; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, 63110, USA. .
Cavalli V; Department of Neuroscience, Washington University School of Medicine, St Louis, MO, 63110, USA. .; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, 63110, USA. .; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA. .
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Źródło:
Scientific reports [Sci Rep] 2021 Jul 21; Vol. 11 (1), pp. 14924. Date of Electronic Publication: 2021 Jul 21.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Axons/*physiology
Chromatin/*genetics
Chromatin/*metabolism
Nerve Regeneration/*genetics
Optic Nerve/*physiology
Retinal Ganglion Cells/*physiology
Animals ; CREB-Binding Protein/genetics ; CREB-Binding Protein/metabolism ; CREB-Binding Protein/physiology ; Gene Expression ; Mice ; Optic Nerve Injuries/genetics ; Optic Nerve Injuries/physiopathology ; Rats ; Transcription Factors/metabolism ; Transcription Factors/physiology
Czasopismo naukowe
Tytuł:
Visual recovery following optic nerve crush in male and female wild-type and TRIF-deficient mice.
Autorzy:
Du YL; Emory University College of Arts and Sciences, Neuroscience and Behavioral Biology Program, GA, USA.
Sergeeva EG; Department of Emergency Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Stein DG; Emory University College of Arts and Sciences, Neuroscience and Behavioral Biology Program, GA, USA.; Department of Emergency Medicine, Emory University School of Medicine, Atlanta, GA, USA.
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Źródło:
Restorative neurology and neuroscience [Restor Neurol Neurosci] 2020; Vol. 38 (5), pp. 355-368.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adaptor Proteins, Vesicular Transport/*metabolism
Evoked Potentials, Visual/*physiology
Inflammation/*metabolism
Nerve Regeneration/*physiology
Optic Nerve Injuries/*metabolism
Recovery of Function/*physiology
Retinal Ganglion Cells/*physiology
Visual Perception/*physiology
Animals ; Behavior, Animal/physiology ; Disease Models, Animal ; Female ; Inflammation/immunology ; Male ; Mice ; Mice, Knockout ; Optic Nerve Injuries/immunology ; Signal Transduction/physiology ; Toll-Like Receptor 3/metabolism
Czasopismo naukowe
Tytuł:
Lab review: Molecular dissection of the signal transduction pathways associated with PTEN deletion-induced optic nerve regeneration.
Autorzy:
Huang H; Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA, USA.
Kaur S; Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA, USA.
Hu Y; Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA, USA.
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Źródło:
Restorative neurology and neuroscience [Restor Neurol Neurosci] 2019; Vol. 37 (6), pp. 545-552.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Nerve Regeneration/*physiology
Optic Nerve Injuries/*metabolism
PTEN Phosphohydrolase/*deficiency
Signal Transduction/*physiology
Animals ; Mice ; Optic Nerve/metabolism ; Optic Nerve/pathology ; Optic Nerve Injuries/genetics ; Optic Nerve Injuries/pathology ; PTEN Phosphohydrolase/genetics ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł:
Branched-Chain Amino Acids Enhance Retinal Ganglion Cell Survival and Axon Regeneration after Optic Nerve Transection in Rats.
Autorzy:
Wang T; a Department of Occupational & Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health , Fourth Military Medical University , Xi'an , China.
Wei XY; b Department of Neurobiology and Collaborative Innovation Center for Brain Science, School of Basic Medicine , Fourth Military Medical University , Xi'an , China.
Yang AA; c Department of Pathology , The 253rd Hospital of PLA , Hohhot , China.
Liu Z; d Department of Neurology , Lanzhou PLA General Hospital , Lanzhou , China.
Wang SQ; e State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases , Fourth Military Medical University , Xi'an , China.
You YY; f Ernest Mario School of Pharmacy , Rutgers, the State University of New Jersey , Piscataway , USA.
Kuang F; b Department of Neurobiology and Collaborative Innovation Center for Brain Science, School of Basic Medicine , Fourth Military Medical University , Xi'an , China.
You SW; b Department of Neurobiology and Collaborative Innovation Center for Brain Science, School of Basic Medicine , Fourth Military Medical University , Xi'an , China.
Wu MM; b Department of Neurobiology and Collaborative Innovation Center for Brain Science, School of Basic Medicine , Fourth Military Medical University , Xi'an , China.
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Źródło:
Current eye research [Curr Eye Res] 2018 Dec; Vol. 43 (12), pp. 1500-1506. Date of Electronic Publication: 2018 Sep 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Amino Acids, Branched-Chain/*therapeutic use
Nerve Regeneration/*drug effects
Optic Nerve Injuries/*drug therapy
Retinal Ganglion Cells/*drug effects
Animals ; Cell Survival ; Disease Models, Animal ; Female ; Optic Nerve/drug effects ; Optic Nerve/metabolism ; Optic Nerve/pathology ; Optic Nerve Injuries/metabolism ; Optic Nerve Injuries/pathology ; Rats ; Rats, Sprague-Dawley ; Retinal Ganglion Cells/metabolism ; Retinal Ganglion Cells/pathology
Czasopismo naukowe
Tytuł:
Optic nerve regeneration: A long view.
Autorzy:
Yin Y; Laboratories for Neuroscience Research in Neurosurgery, Boston Children's Hospital, Boston, MA, USA.; Department of Neurosurgery, Boston Children's Hospital, Boston, MA, USA.; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.; Department of Neurosurgery, Harvard Medical School, Boston, MA, USA.
De Lima S; Laboratories for Neuroscience Research in Neurosurgery, Boston Children's Hospital, Boston, MA, USA.; Department of Neurosurgery, Boston Children's Hospital, Boston, MA, USA.; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.; Department of Neurosurgery, Harvard Medical School, Boston, MA, USA.
Gilbert HY; Laboratories for Neuroscience Research in Neurosurgery, Boston Children's Hospital, Boston, MA, USA.; Department of Neurosurgery, Boston Children's Hospital, Boston, MA, USA.
Hanovice NJ; Laboratories for Neuroscience Research in Neurosurgery, Boston Children's Hospital, Boston, MA, USA.; Department of Neurosurgery, Boston Children's Hospital, Boston, MA, USA.; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.; Department of Neurosurgery, Harvard Medical School, Boston, MA, USA.
Peterson SL; Laboratories for Neuroscience Research in Neurosurgery, Boston Children's Hospital, Boston, MA, USA.; Department of Neurosurgery, Boston Children's Hospital, Boston, MA, USA.; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.; Department of Neurosurgery, Harvard Medical School, Boston, MA, USA.
Sand RM; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.; Department of Neurology, Boston Children's Hospital, Boston, MA, USA.; Department of Neurology, Harvard Medical School, Boston, MA, USA.
Sergeeva EG; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.; Department of Neurology, Boston Children's Hospital, Boston, MA, USA.; Department of Neurology, Harvard Medical School, Boston, MA, USA.
Wong KA; Laboratories for Neuroscience Research in Neurosurgery, Boston Children's Hospital, Boston, MA, USA.; Department of Neurosurgery, Boston Children's Hospital, Boston, MA, USA.; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.; Department of Neurosurgery, Harvard Medical School, Boston, MA, USA.
Xie L; Laboratories for Neuroscience Research in Neurosurgery, Boston Children's Hospital, Boston, MA, USA.; Department of Neurosurgery, Boston Children's Hospital, Boston, MA, USA.; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.; Department of Neurosurgery, Harvard Medical School, Boston, MA, USA.
Benowitz LI; Laboratories for Neuroscience Research in Neurosurgery, Boston Children's Hospital, Boston, MA, USA.; Department of Neurosurgery, Boston Children's Hospital, Boston, MA, USA.; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.; Department of Neurosurgery, Harvard Medical School, Boston, MA, USA.; Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
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Źródło:
Restorative neurology and neuroscience [Restor Neurol Neurosci] 2019; Vol. 37 (6), pp. 525-544.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Nerve Regeneration/*physiology
Optic Nerve/*physiology
Optic Nerve Injuries/*metabolism
Retinal Ganglion Cells/*metabolism
Animals ; Axons/metabolism ; Axons/ultrastructure ; Humans ; Inflammation Mediators/metabolism ; Optic Nerve/ultrastructure ; Optic Nerve Injuries/pathology ; Retinal Ganglion Cells/ultrastructure
Czasopismo naukowe
Tytuł:
Transcriptional repression of PTEN in neural cells using CRISPR/dCas9 epigenetic editing.
Autorzy:
Moses C; School of Human Sciences, Faculty of Science, The University of Western Australia, 35 Stirling Highway, Perth, WA, 6009, Australia.; Cancer Epigenetics Laboratory, The Harry Perkins Institute of Medical Research, 6 Verdun Street, Nedlands, WA, 6009, Australia.
Hodgetts SI; School of Human Sciences, Faculty of Science, The University of Western Australia, 35 Stirling Highway, Perth, WA, 6009, Australia.; Perron Institute for Neurological and Translational Science, 8 Verdun Street, Nedlands, WA, 6009, Australia.
Nugent F; Cancer Epigenetics Laboratory, The Harry Perkins Institute of Medical Research, 6 Verdun Street, Nedlands, WA, 6009, Australia.; School of Molecular Sciences, Faculty of Science, The University of Western Australia, 35 Stirling Highway, Perth, WA, 6009, Australia.
Ben-Ary G; School of Human Sciences, Faculty of Science, The University of Western Australia, 35 Stirling Highway, Perth, WA, 6009, Australia.
Park KK; Department of Neurological Surgery, Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.
Blancafort P; School of Human Sciences, Faculty of Science, The University of Western Australia, 35 Stirling Highway, Perth, WA, 6009, Australia. .; Cancer Epigenetics Laboratory, The Harry Perkins Institute of Medical Research, 6 Verdun Street, Nedlands, WA, 6009, Australia. .; Greehey Children's Cancer Research Institute, UT Health San Antonio, 8403 Floyd Curl Drive, San Antonio, TX, 78229, USA. .
Harvey AR; School of Human Sciences, Faculty of Science, The University of Western Australia, 35 Stirling Highway, Perth, WA, 6009, Australia. .; Perron Institute for Neurological and Translational Science, 8 Verdun Street, Nedlands, WA, 6009, Australia. .
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Źródło:
Scientific reports [Sci Rep] 2020 Jul 09; Vol. 10 (1), pp. 11393. Date of Electronic Publication: 2020 Jul 09.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Editing/*methods
Nerve Regeneration/*genetics
PTEN Phosphohydrolase/*genetics
5' Untranslated Regions/genetics ; Animals ; Axons/physiology ; CRISPR-Cas Systems/genetics ; Cell Line, Tumor ; Genetic Therapy/methods ; Genetic Vectors/genetics ; HEK293 Cells ; Humans ; Lentivirus/genetics ; Neuronal Outgrowth/genetics ; Optic Nerve/physiology ; Optic Nerve Injuries/therapy ; Promoter Regions, Genetic/genetics ; RNA Interference ; RNA, Guide, CRISPR-Cas Systems/genetics ; RNA, Small Interfering/metabolism ; Rats ; Repressor Proteins/genetics ; Spinal Cord Injuries/therapy ; Transcription, Genetic ; Transduction, Genetic/methods
Czasopismo naukowe
Tytuł:
Therapeutic effect of adipose‑derived stem cell transplantation on optic nerve injury in rats.
Autorzy:
Li X; Department of Pharmacy, Yantai Infectious Diseases Hospital, Yantai, Shandong 264000, P.R. China.
Zhao S; Department of Ophthalmology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China.
Wang L; Department of Ophthalmology, Yantaishan Hospital, Yantai, Shandong 264000, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2018 Feb; Vol. 17 (2), pp. 2529-2534. Date of Electronic Publication: 2017 Nov 20.
Typ publikacji:
Journal Article
MeSH Terms:
Nerve Regeneration*
Stem Cell Transplantation*
Adipose Tissue/*cytology
Optic Nerve Injuries/*therapy
Stem Cells/*cytology
Animals ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism ; Cell Count ; Disease Models, Animal ; GAP-43 Protein/genetics ; GAP-43 Protein/metabolism ; Gene Expression ; Male ; Optic Nerve Injuries/genetics ; Optic Nerve Injuries/metabolism ; Rats ; Retina/metabolism ; Retina/pathology ; Retinal Ganglion Cells/metabolism
Czasopismo naukowe
Tytuł:
Retinal Ganglion Cell Survival and Axon Regeneration after Optic Nerve Transection is Driven by Cellular Intravitreal Sciatic Nerve Grafts.
Autorzy:
Ahmed Z; Neuroscience and Ophthalmology, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, B15 2TT, UK.
Suggate EL; Neuroscience and Ophthalmology, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, B15 2TT, UK.
Logan A; Neuroscience and Ophthalmology, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, B15 2TT, UK.
Berry M; Neuroscience and Ophthalmology, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, B15 2TT, UK.
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Źródło:
Cells [Cells] 2020 May 27; Vol. 9 (6). Date of Electronic Publication: 2020 May 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Nerve Regeneration*
Axons/*pathology
Optic Nerve Injuries/*pathology
Retinal Ganglion Cells/*pathology
Sciatic Nerve/*transplantation
Animals ; Astrocytes/pathology ; Cell Survival ; Ependymoglial Cells/pathology ; Intravitreal Injections ; Ligands ; Macrophage Activation ; Macrophages/pathology ; Male ; Rats, Inbred F344 ; Receptors, Nerve Growth Factor/metabolism ; rho GTP-Binding Proteins/metabolism
Czasopismo naukowe
Tytuł:
Cellular reprogramming for successful CNS axon regeneration is driven by a temporally changing cast of transcription factors.
Autorzy:
Dhara SP; Department of Biological Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI, 53201, USA.
Rau A; GABI, INRA, AgroParisTech, Universite Paris-Saclay, 78350, Jouy-en-Josas, France.; Joseph J Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI, 53201, USA.
Flister MJ; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Recka NM; Department of Biological Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI, 53201, USA.
Laiosa MD; Joseph J Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI, 53201, USA.
Auer PL; Joseph J Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI, 53201, USA.
Udvadia AJ; Department of Biological Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI, 53201, USA. .
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Źródło:
Scientific reports [Sci Rep] 2019 Oct 02; Vol. 9 (1), pp. 14198. Date of Electronic Publication: 2019 Oct 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cellular Reprogramming/*genetics
Nerve Regeneration/*genetics
Retinal Ganglion Cells/*metabolism
Transcription Factors/*genetics
Animals ; Axons/metabolism ; Central Nervous System/growth & development ; Central Nervous System/metabolism ; Humans ; Optic Nerve/growth & development ; Optic Nerve/pathology ; Optic Nerve Injuries/genetics ; Optic Nerve Injuries/pathology ; Recovery of Function/genetics ; Zebrafish/genetics ; Zebrafish/growth & development
Czasopismo naukowe
Tytuł:
Optic nerve regeneration in larval zebrafish exhibits spontaneous capacity for retinotopic but not tectum specific axon targeting.
Autorzy:
Harvey BM; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
Baxter M; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
Granato M; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
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Źródło:
PloS one [PLoS One] 2019 Jun 20; Vol. 14 (6), pp. e0218667. Date of Electronic Publication: 2019 Jun 20 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Axons/*physiology
Nerve Regeneration/*physiology
Optic Nerve/*physiopathology
Retinal Ganglion Cells/*physiology
Superior Colliculi/*physiopathology
Zebrafish/*physiology
Animals ; Animals, Genetically Modified ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; LIM-Homeodomain Proteins/genetics ; LIM-Homeodomain Proteins/metabolism ; Larva ; Optic Nerve Injuries/rehabilitation ; Optic Nerve Injuries/veterinary ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Zebrafish/growth & development
Czasopismo naukowe
Tytuł:
MTP18 is a Novel Regulator of Mitochondrial Fission in CNS Neuron Development, Axonal Growth, and Injury Responses.
Autorzy:
Kreymerman A; Byers Eye Institute and Spencer Center for Vision Research, Stanford University, Palo Alto, CA, 94303, USA. .; University of Miami Miller School of Medicine, Miami, FL, 33136, USA. .
Buickians DN; Byers Eye Institute and Spencer Center for Vision Research, Stanford University, Palo Alto, CA, 94303, USA.
Nahmou MM; Byers Eye Institute and Spencer Center for Vision Research, Stanford University, Palo Alto, CA, 94303, USA.
Tran T; University of California, San Diego, CA, 92093, USA.
Galvao J; Byers Eye Institute and Spencer Center for Vision Research, Stanford University, Palo Alto, CA, 94303, USA.
Wang Y; University of California, San Diego, CA, 92093, USA.
Sun N; University of California, San Diego, CA, 92093, USA.
Bazik L; University of California, San Diego, CA, 92093, USA.
Huynh SK; Byers Eye Institute and Spencer Center for Vision Research, Stanford University, Palo Alto, CA, 94303, USA.
Cho IJ; Byers Eye Institute and Spencer Center for Vision Research, Stanford University, Palo Alto, CA, 94303, USA.
Boczek T; Byers Eye Institute and Spencer Center for Vision Research, Stanford University, Palo Alto, CA, 94303, USA.
Chang KC; Byers Eye Institute and Spencer Center for Vision Research, Stanford University, Palo Alto, CA, 94303, USA.
Kunzevitzky NJ; Byers Eye Institute and Spencer Center for Vision Research, Stanford University, Palo Alto, CA, 94303, USA.
Goldberg JL; Byers Eye Institute and Spencer Center for Vision Research, Stanford University, Palo Alto, CA, 94303, USA.
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Źródło:
Scientific reports [Sci Rep] 2019 Jul 23; Vol. 9 (1), pp. 10669. Date of Electronic Publication: 2019 Jul 23.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Axons/*metabolism
Membrane Proteins/*metabolism
Mitochondrial Dynamics/*physiology
Mitochondrial Proteins/*metabolism
Nerve Regeneration/*physiology
Neurons/*metabolism
Animals ; Membrane Proteins/genetics ; Mitochondria/metabolism ; Mitochondrial Proteins/genetics ; Nerve Crush ; Neuronal Outgrowth/physiology ; Optic Nerve Injuries/metabolism ; Rats ; Rats, Sprague-Dawley ; Signal Transduction
Czasopismo naukowe
Tytuł:
Virally delivered, constitutively active NFκB improves survival of injured retinal ganglion cells.
Autorzy:
Dvoriantchikova G; Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.
Pappas S; Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.
Luo X; Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, USA.
Ribeiro M; Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, USA.
Danek D; Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.
Pelaez D; Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.
Park KK; Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, USA.
Ivanov D; Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.; Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, USA.
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Źródło:
The European journal of neuroscience [Eur J Neurosci] 2016 Dec; Vol. 44 (11), pp. 2935-2943. Date of Electronic Publication: 2016 Sep 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Nerve Regeneration*
Axons/*metabolism
Optic Nerve Injuries/*metabolism
Retinal Ganglion Cells/*metabolism
Transcription Factor RelA/*genetics
Animals ; Axons/physiology ; Cell Line ; Cells, Cultured ; Dependovirus/genetics ; Genetic Therapy ; Mice ; Mice, Inbred C57BL ; Neuronal Outgrowth ; Optic Nerve Injuries/therapy ; Transcription Factor RelA/metabolism
Czasopismo naukowe
Tytuł:
Prior Exposure to Immunosuppressors Sensitizes Retinal Microglia and Accelerates Optic Nerve Regeneration in Zebrafish.
Autorzy:
Bollaerts I; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, 3000 Leuven, Belgium.
Van Houcke J; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, 3000 Leuven, Belgium.
Beckers A; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, 3000 Leuven, Belgium.
Lemmens K; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, 3000 Leuven, Belgium.
Vanhunsel S; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, 3000 Leuven, Belgium.
De Groef L; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, 3000 Leuven, Belgium.
Moons L; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, 3000 Leuven, Belgium.
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Źródło:
Mediators of inflammation [Mediators Inflamm] 2019 Feb 10; Vol. 2019, pp. 6135795. Date of Electronic Publication: 2019 Feb 10 (Print Publication: 2019).
Typ publikacji:
Journal Article
MeSH Terms:
Microglia/*physiology
Nerve Regeneration/*physiology
Optic Nerve Injuries/*physiopathology
Retina/*physiology
Animals ; Central Nervous System/physiology ; Immunosuppression Therapy ; Software ; Zebrafish
Czasopismo naukowe

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