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Tytuł:
7,8-Dihydroxiflavone Maintains Retinal Functionality and Protects Various Types of RGCs in Adult Rats with Optic Nerve Transection.
Autorzy:
Gallego-Ortega A; Departamento de Oftalmología, Instituto Murciano de Investigación Biosanitaria (IMIB) Virgen de la Arrixaca, Universidad de Murcia, Campus de CC de la Salud, El Palmar, 30120 Murcia, Spain.
Vidal-Villegas B; Departamento de Oftalmología, Instituto Murciano de Investigación Biosanitaria (IMIB) Virgen de la Arrixaca, Universidad de Murcia, Campus de CC de la Salud, El Palmar, 30120 Murcia, Spain.; Servicio de Oftalmología, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdIC), 28040 Madrid, Spain.
Norte-Muñoz M; Departamento de Oftalmología, Instituto Murciano de Investigación Biosanitaria (IMIB) Virgen de la Arrixaca, Universidad de Murcia, Campus de CC de la Salud, El Palmar, 30120 Murcia, Spain.
Salinas-Navarro M; Departamento de Oftalmología, Instituto Murciano de Investigación Biosanitaria (IMIB) Virgen de la Arrixaca, Universidad de Murcia, Campus de CC de la Salud, El Palmar, 30120 Murcia, Spain.
Avilés-Trigueros M; Departamento de Oftalmología, Instituto Murciano de Investigación Biosanitaria (IMIB) Virgen de la Arrixaca, Universidad de Murcia, Campus de CC de la Salud, El Palmar, 30120 Murcia, Spain.
Villegas-Pérez MP; Departamento de Oftalmología, Instituto Murciano de Investigación Biosanitaria (IMIB) Virgen de la Arrixaca, Universidad de Murcia, Campus de CC de la Salud, El Palmar, 30120 Murcia, Spain.
Vidal-Sanz M; Departamento de Oftalmología, Instituto Murciano de Investigación Biosanitaria (IMIB) Virgen de la Arrixaca, Universidad de Murcia, Campus de CC de la Salud, El Palmar, 30120 Murcia, Spain.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 30; Vol. 22 (21). Date of Electronic Publication: 2021 Oct 30.
Typ publikacji:
Journal Article
MeSH Terms:
Optic Nerve*/metabolism
Optic Nerve*/pathology
Optic Nerve Injuries*/drug therapy
Optic Nerve Injuries*/metabolism
Optic Nerve Injuries*/pathology
Retinal Ganglion Cells*/metabolism
Retinal Ganglion Cells*/pathology
Flavones/*pharmacology
Neuroprotective Agents/*pharmacology
Animals ; Electroretinography ; Female ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
MMP2 Modulates Inflammatory Response during Axonal Regeneration in the Murine Visual System.
Autorzy:
Andries L; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, 3000 Leuven, Belgium.; Leuven Brain Institute, 3000 Leuven, Belgium.
Masin L; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, 3000 Leuven, Belgium.; Leuven Brain Institute, 3000 Leuven, Belgium.
Salinas-Navarro M; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, 3000 Leuven, Belgium.
Zaunz S; Department of Development and Regeneration, Stem Cell Institute, KU Leuven, 3000 Leuven, Belgium.
Claes M; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, 3000 Leuven, Belgium.; Leuven Brain Institute, 3000 Leuven, Belgium.
Bergmans S; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, 3000 Leuven, Belgium.; Leuven Brain Institute, 3000 Leuven, Belgium.
Brouwers V; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, 3000 Leuven, Belgium.
Lefevere E; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, 3000 Leuven, Belgium.
Verfaillie C; Department of Development and Regeneration, Stem Cell Institute, KU Leuven, 3000 Leuven, Belgium.
Movahedi K; Myeloid Cell Immunology Lab, VIB, Center for Inflammation Research, 1090 Brussels, Belgium.; Laboratory of Cellular and Molecular Immunology, Department of Biology, Vrije Universiteit Brussel, 1050 Brussels, Belgium.
De Groef L; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, 3000 Leuven, Belgium.; Leuven Brain Institute, 3000 Leuven, Belgium.
Moons L; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, 3000 Leuven, Belgium.; Leuven Brain Institute, 3000 Leuven, Belgium.
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Źródło:
Cells [Cells] 2021 Jul 02; Vol. 10 (7). Date of Electronic Publication: 2021 Jul 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Bone Marrow Transplantation*
Axons/*immunology
Matrix Metalloproteinase 2/*genetics
Nerve Regeneration/*immunology
Optic Nerve/*immunology
Optic Nerve Injuries/*immunology
Animals ; Antigens, Ly/genetics ; Antigens, Ly/immunology ; Axons/ultrastructure ; CX3C Chemokine Receptor 1/genetics ; CX3C Chemokine Receptor 1/immunology ; Cell Movement ; GAP-43 Protein/genetics ; GAP-43 Protein/immunology ; Gene Expression Regulation ; Immunity, Innate ; Inflammation ; Leukocyte Common Antigens/genetics ; Leukocyte Common Antigens/immunology ; Matrix Metalloproteinase 2/deficiency ; Matrix Metalloproteinase 2/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Myeloid Cells/cytology ; Myeloid Cells/immunology ; Nerve Regeneration/genetics ; Optic Nerve/metabolism ; Optic Nerve Injuries/genetics ; Optic Nerve Injuries/pathology ; Retina/immunology ; Retina/injuries ; Retina/metabolism ; Transplantation, Heterologous ; Whole-Body Irradiation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Mesoscopic cortical network reorganization during recovery of optic nerve injury in GCaMP6s mice.
Autorzy:
Groleau M; Laboratoire de Neurobiologie de la Cognition Visuelle, École d'Optométrie, Université de Montréal, Montréal, QC, H3T 1P1, Canada.
Nazari-Ahangarkolaee M; Department of Neuroscience, Canadian Centre for Behavioural Neuroscience (CCBN), University of Lethbridge, Lethbridge, AB, T1K 3M4, Canada.
Vanni MP; Laboratoire de Neurophotonique, École d'Optométrie, Université de Montréal, Montréal, QC, H3T 1P1, Canada.
Higgins JL; Laboratoire de Neurobiologie de la Cognition Visuelle, École d'Optométrie, Université de Montréal, Montréal, QC, H3T 1P1, Canada.
Vézina Bédard AS; Laboratoire de Neurobiologie de la Cognition Visuelle, École d'Optométrie, Université de Montréal, Montréal, QC, H3T 1P1, Canada.
Sabel BA; Institute of Medical Psychology, Medical Faculty, Otto-V.-Guericke University of Magdeburg, 39120, Magdeburg, Germany.
Mohajerani MH; Department of Neuroscience, Canadian Centre for Behavioural Neuroscience (CCBN), University of Lethbridge, Lethbridge, AB, T1K 3M4, Canada. .
Vaucher E; Laboratoire de Neurobiologie de la Cognition Visuelle, École d'Optométrie, Université de Montréal, Montréal, QC, H3T 1P1, Canada. .
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Źródło:
Scientific reports [Sci Rep] 2020 Dec 08; Vol. 10 (1), pp. 21472. Date of Electronic Publication: 2020 Dec 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Nerve Net/*physiopathology
Optic Nerve/*physiopathology
Optic Nerve Injuries/*physiopathology
Visual Cortex/*physiopathology
Animals ; Calcium/analysis ; Disease Models, Animal ; Female ; Male ; Mice, Inbred C57BL ; Nerve Crush ; Nerve Net/pathology ; Optic Nerve/pathology ; Optic Nerve Injuries/pathology ; Optic Nerve Injuries/therapy ; Visual Acuity ; Visual Cortex/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Philanthotoxin-343 attenuates retinal and optic nerve injury, and protects visual function in rats with N-methyl-D-aspartate-induced excitotoxicity.
Autorzy:
Fazel MF; Institute of Medical Science Technology, Universiti Kuala Lumpur, Kuala Lumpur, Malaysia.
Abu IF; Institute of Medical Science Technology, Universiti Kuala Lumpur, Kuala Lumpur, Malaysia.
Mohamad MHN; Institute of Medical Science Technology, Universiti Kuala Lumpur, Kuala Lumpur, Malaysia.
Agarwal R; School of Medicine, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia.
Iezhitsa I; School of Medicine, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia.
Bakar NS; Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia.
Juliana N; Faculty of Medicine & Health Sciences, Universiti Sains Islam Malaysia, Indah, Kuala Lumpur, Malaysia.
Mellor IR; School of Life Sciences, Faculty of Medicine & Health Sciences, University of Nottingham, Nottingham, United Kingdom.
Franzyk H; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
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Źródło:
PloS one [PLoS One] 2020 Jul 24; Vol. 15 (7), pp. e0236450. Date of Electronic Publication: 2020 Jul 24 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Neuroprotective Agents*/pharmacology
Neuroprotective Agents*/therapeutic use
Phenols*/pharmacology
Phenols*/therapeutic use
Polyamines*/pharmacology
Polyamines*/therapeutic use
Optic Nerve/*drug effects
Optic Nerve Injuries/*drug therapy
Retinal Ganglion Cells/*drug effects
Animals ; Male ; N-Methylaspartate/toxicity ; Optic Nerve/pathology ; Optic Nerve Injuries/chemically induced ; Rats ; Rats, Sprague-Dawley ; Retinal Ganglion Cells/pathology ; Vision, Ocular/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Human Pluripotent Stem Cell-Derived Neural Progenitor Cells Promote Retinal Ganglion Cell Survival and Axon Recovery in an Optic Nerve Compression Animal Model.
Autorzy:
Park M; Department of Ophthalmology, CHA Bundang Medical Center, CHA University, Seongnam 13496, Gyeonggi-do, Korea.
Kim HM; Department of Biomedical Science, CHA University, Seongnam 13488, Gyeonggi-do, Korea.
Shin HA; Department of Ophthalmology, CHA Bundang Medical Center, CHA University, Seongnam 13496, Gyeonggi-do, Korea.
Lee SH; Department of Ophthalmology, CHA Bundang Medical Center, CHA University, Seongnam 13496, Gyeonggi-do, Korea.
Hwang DY; Department of Biomedical Science, CHA University, Seongnam 13488, Gyeonggi-do, Korea.; Department of Microbiology, School of Medicine, CHA University, Seongnam 13488, Gyeonggi-do, Korea.
Lew H; Department of Ophthalmology, CHA Bundang Medical Center, CHA University, Seongnam 13496, Gyeonggi-do, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Nov 20; Vol. 22 (22). Date of Electronic Publication: 2021 Nov 20.
Typ publikacji:
Journal Article
MeSH Terms:
Neural Stem Cells/*transplantation
Optic Nerve/*growth & development
Optic Nerve Diseases/*therapy
Optic Nerve Injuries/*therapy
Pluripotent Stem Cells/*transplantation
Animals ; Axons/metabolism ; Axons/physiology ; Cell Survival/genetics ; Cell- and Tissue-Based Therapy ; Disease Models, Animal ; Female ; Humans ; Nerve Regeneration/genetics ; Optic Nerve/pathology ; Optic Nerve/transplantation ; Optic Nerve Diseases/pathology ; Pregnancy ; Rats ; Retinal Ganglion Cells/transplantation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Neuroinflammation and Optic Nerve Regeneration: Where Do We Stand in Elucidating Underlying Cellular and Molecular Players?
Autorzy:
Andries L; Department of Biology, Neural Circuit Development and Regeneration Research Group, KU Leuven, Leuven, Belgium.
De Groef L; Department of Biology, Neural Circuit Development and Regeneration Research Group, KU Leuven, Leuven, Belgium.
Moons L; Department of Biology, Neural Circuit Development and Regeneration Research Group, KU Leuven, Leuven, Belgium.
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Źródło:
Current eye research [Curr Eye Res] 2020 Mar; Vol. 45 (3), pp. 397-409. Date of Electronic Publication: 2019 Oct 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Axons/*physiology
Nerve Regeneration/*physiology
Optic Nerve/*physiopathology
Optic Nerve Injuries/*physiopathology
Animals ; Humans ; Optic Nerve/pathology ; Optic Nerve Injuries/metabolism ; Optic Nerve Injuries/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Effects of intravitreal injection of siRNA against caspase-2 on retinal and optic nerve degeneration in air blast induced ocular trauma.
Autorzy:
Thomas CN; Neuroscience and Ophthalmology, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.; School of Biomedical Sciences, Institute of Clinical Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Bernardo-Colón A; Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
Courtie E; Neuroscience and Ophthalmology, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.; Ophthalmology Department, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Essex G; Neuroscience and Ophthalmology, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Rex TS; Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Ophthalmology and Visual Sciences, Vanderbilt University School of Medicine, Nashville, TN, USA.
Blanch RJ; Neuroscience and Ophthalmology, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK. .; Ophthalmology Department, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK. .; Academic Department of Military Surgery and Trauma, Royal Centre for Defence Medicine, Birmingham, UK. .; Centre for Trauma Sciences Research, University of Birmingham, Birmingham, B15 2TT, UK. .
Ahmed Z; Neuroscience and Ophthalmology, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK. .; Centre for Trauma Sciences Research, University of Birmingham, Birmingham, B15 2TT, UK. .
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Źródło:
Scientific reports [Sci Rep] 2021 Aug 19; Vol. 11 (1), pp. 16839. Date of Electronic Publication: 2021 Aug 19.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Air*
Caspase 2/*metabolism
Eye Injuries/*pathology
Optic Nerve/*pathology
RNA, Small Interfering/*administration & dosage
Retina/*pathology
Animals ; Axons/pathology ; Disease Models, Animal ; Green Fluorescent Proteins/metabolism ; Inflammation/pathology ; Intravitreal Injections ; Male ; Mice, Inbred C57BL ; Optic Nerve Injuries/pathology ; RNA-Binding Proteins/metabolism ; Retinal Ganglion Cells/pathology ; Vitreous Body/pathology ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Genome-wide chromatin accessibility analyses provide a map for enhancing optic nerve regeneration.
Autorzy:
Pita-Thomas W; Department of Neuroscience, Washington University School of Medicine, St Louis, MO, 63110, USA.
Gonçalves TM; Department of Neuroscience, Washington University School of Medicine, St Louis, MO, 63110, USA.
Kumar A; Department of Neuroscience, Washington University School of Medicine, St Louis, MO, 63110, USA.
Zhao G; Department of Neuroscience, Washington University School of Medicine, St Louis, MO, 63110, USA. .; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, 63110, USA. .
Cavalli V; Department of Neuroscience, Washington University School of Medicine, St Louis, MO, 63110, USA. .; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, 63110, USA. .; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA. .
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Źródło:
Scientific reports [Sci Rep] 2021 Jul 21; Vol. 11 (1), pp. 14924. Date of Electronic Publication: 2021 Jul 21.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Axons/*physiology
Chromatin/*genetics
Chromatin/*metabolism
Nerve Regeneration/*genetics
Optic Nerve/*physiology
Retinal Ganglion Cells/*physiology
Animals ; CREB-Binding Protein/genetics ; CREB-Binding Protein/metabolism ; CREB-Binding Protein/physiology ; Gene Expression ; Mice ; Optic Nerve Injuries/genetics ; Optic Nerve Injuries/physiopathology ; Rats ; Transcription Factors/metabolism ; Transcription Factors/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Long-term neuronal survival, regeneration, and transient target reconnection after optic nerve crush and mesenchymal stem cell transplantation.
Autorzy:
Mesentier-Louro LA; Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-902, Brazil. .
Teixeira-Pinheiro LC; Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-902, Brazil.
Gubert F; Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-902, Brazil.
Vasques JF; Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-902, Brazil.; National Institute of Science and Technology for Regenerative Medicine-REGENERE, Rio de Janeiro, Brazil.
Silva-Junior AJ; Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-902, Brazil.; National Institute of Science and Technology for Regenerative Medicine-REGENERE, Rio de Janeiro, Brazil.
Chimeli-Ormonde L; Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-902, Brazil.; National Institute of Science and Technology for Regenerative Medicine-REGENERE, Rio de Janeiro, Brazil.
Nascimento-Dos-Santos G; Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-902, Brazil.
Mendez-Otero R; Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-902, Brazil.; National Institute of Science and Technology for Regenerative Medicine-REGENERE, Rio de Janeiro, Brazil.
Santiago MF; Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-902, Brazil.
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Źródło:
Stem cell research & therapy [Stem Cell Res Ther] 2019 Apr 17; Vol. 10 (1), pp. 121. Date of Electronic Publication: 2019 Apr 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mesenchymal Stem Cell Transplantation*
Nerve Regeneration*
Optic Nerve Injuries*/metabolism
Optic Nerve Injuries*/pathology
Optic Nerve Injuries*/therapy
Mesenchymal Stem Cells/*metabolism
Optic Nerve/*physiology
Allografts ; Animals ; Early Growth Response Protein 1/metabolism ; Female ; Male ; Mesenchymal Stem Cells/pathology ; Rats ; Retinal Ganglion Cells/metabolism ; Retinal Ganglion Cells/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Optic nerve regeneration: A long view.
Autorzy:
Yin Y; Laboratories for Neuroscience Research in Neurosurgery, Boston Children's Hospital, Boston, MA, USA.; Department of Neurosurgery, Boston Children's Hospital, Boston, MA, USA.; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.; Department of Neurosurgery, Harvard Medical School, Boston, MA, USA.
De Lima S; Laboratories for Neuroscience Research in Neurosurgery, Boston Children's Hospital, Boston, MA, USA.; Department of Neurosurgery, Boston Children's Hospital, Boston, MA, USA.; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.; Department of Neurosurgery, Harvard Medical School, Boston, MA, USA.
Gilbert HY; Laboratories for Neuroscience Research in Neurosurgery, Boston Children's Hospital, Boston, MA, USA.; Department of Neurosurgery, Boston Children's Hospital, Boston, MA, USA.
Hanovice NJ; Laboratories for Neuroscience Research in Neurosurgery, Boston Children's Hospital, Boston, MA, USA.; Department of Neurosurgery, Boston Children's Hospital, Boston, MA, USA.; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.; Department of Neurosurgery, Harvard Medical School, Boston, MA, USA.
Peterson SL; Laboratories for Neuroscience Research in Neurosurgery, Boston Children's Hospital, Boston, MA, USA.; Department of Neurosurgery, Boston Children's Hospital, Boston, MA, USA.; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.; Department of Neurosurgery, Harvard Medical School, Boston, MA, USA.
Sand RM; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.; Department of Neurology, Boston Children's Hospital, Boston, MA, USA.; Department of Neurology, Harvard Medical School, Boston, MA, USA.
Sergeeva EG; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.; Department of Neurology, Boston Children's Hospital, Boston, MA, USA.; Department of Neurology, Harvard Medical School, Boston, MA, USA.
Wong KA; Laboratories for Neuroscience Research in Neurosurgery, Boston Children's Hospital, Boston, MA, USA.; Department of Neurosurgery, Boston Children's Hospital, Boston, MA, USA.; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.; Department of Neurosurgery, Harvard Medical School, Boston, MA, USA.
Xie L; Laboratories for Neuroscience Research in Neurosurgery, Boston Children's Hospital, Boston, MA, USA.; Department of Neurosurgery, Boston Children's Hospital, Boston, MA, USA.; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.; Department of Neurosurgery, Harvard Medical School, Boston, MA, USA.
Benowitz LI; Laboratories for Neuroscience Research in Neurosurgery, Boston Children's Hospital, Boston, MA, USA.; Department of Neurosurgery, Boston Children's Hospital, Boston, MA, USA.; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.; Department of Neurosurgery, Harvard Medical School, Boston, MA, USA.; Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
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Źródło:
Restorative neurology and neuroscience [Restor Neurol Neurosci] 2019; Vol. 37 (6), pp. 525-544.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Nerve Regeneration/*physiology
Optic Nerve/*physiology
Optic Nerve Injuries/*metabolism
Retinal Ganglion Cells/*metabolism
Animals ; Axons/metabolism ; Axons/ultrastructure ; Humans ; Inflammation Mediators/metabolism ; Optic Nerve/ultrastructure ; Optic Nerve Injuries/pathology ; Retinal Ganglion Cells/ultrastructure
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Possible role of miR-204 in optic nerve injury through the regulation of GAP-43.
Autorzy:
Wang N; Department of Ophthalmology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Yang W; Department of Ophthalmology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650034, P.R. China.
Xiao T; Department of Ophthalmology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Miao Z; Department of Ophthalmology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Luo W; Department of Ophthalmology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
You Z; Department of Ophthalmology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Li G; Department of Ophthalmology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2018 Mar; Vol. 17 (3), pp. 3891-3897. Date of Electronic Publication: 2017 Dec 22.
Typ publikacji:
Journal Article
MeSH Terms:
GAP-43 Protein/*genetics
MicroRNAs/*genetics
Optic Nerve/*metabolism
Optic Nerve Injuries/*genetics
Retinal Ganglion Cells/*metabolism
Animals ; Antagomirs/genetics ; Antagomirs/metabolism ; Apoptosis ; GAP-43 Protein/metabolism ; Gene Expression Regulation ; Male ; MicroRNAs/agonists ; MicroRNAs/antagonists & inhibitors ; MicroRNAs/metabolism ; Myeloid Differentiation Factor 88/genetics ; Myeloid Differentiation Factor 88/metabolism ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Nerve Crush/methods ; Nerve Regeneration/physiology ; Oligoribonucleotides/genetics ; Oligoribonucleotides/metabolism ; Optic Nerve/blood supply ; Optic Nerve/pathology ; Optic Nerve Injuries/metabolism ; Optic Nerve Injuries/pathology ; Optic Nerve Injuries/therapy ; Rats ; Rats, Sprague-Dawley ; Retinal Ganglion Cells/pathology ; Retinal Vessels/metabolism ; Retinal Vessels/pathology ; Signal Transduction ; Toll-Like Receptor 4/genetics ; Toll-Like Receptor 4/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Optic nerve regeneration in larval zebrafish exhibits spontaneous capacity for retinotopic but not tectum specific axon targeting.
Autorzy:
Harvey BM; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
Baxter M; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
Granato M; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
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Źródło:
PloS one [PLoS One] 2019 Jun 20; Vol. 14 (6), pp. e0218667. Date of Electronic Publication: 2019 Jun 20 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Axons/*physiology
Nerve Regeneration/*physiology
Optic Nerve/*physiopathology
Retinal Ganglion Cells/*physiology
Superior Colliculi/*physiopathology
Zebrafish/*physiology
Animals ; Animals, Genetically Modified ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; LIM-Homeodomain Proteins/genetics ; LIM-Homeodomain Proteins/metabolism ; Larva ; Optic Nerve Injuries/rehabilitation ; Optic Nerve Injuries/veterinary ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Zebrafish/growth & development
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The effects of immune protein CD3ζ development and degeneration of retinal neurons after optic nerve injury.
Autorzy:
He T; Eye Center Remin Hospital of Wuhan University Wuhan, Hubei, PR China.; Department of Ophthalmology and Visual Science John Moran Eye Center University of Utah School of Medicine, Salt Lake City, UT, United States of America.
Mortensen X; Department of Ophthalmology and Visual Science John Moran Eye Center University of Utah School of Medicine, Salt Lake City, UT, United States of America.
Wang P; Department of Ophthalmology and Visual Science John Moran Eye Center University of Utah School of Medicine, Salt Lake City, UT, United States of America.
Tian N; Department of Ophthalmology and Visual Science John Moran Eye Center University of Utah School of Medicine, Salt Lake City, UT, United States of America.; VA Salt Lake City Health Care System, Salt Lake City, UT, United States of America.
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Źródło:
PloS one [PLoS One] 2017 Apr 25; Vol. 12 (4), pp. e0175522. Date of Electronic Publication: 2017 Apr 25 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
CD3 Complex/*immunology
Optic Nerve/*pathology
Optic Nerve Injuries/*pathology
Retinal Ganglion Cells/*pathology
Amacrine Cells/immunology ; Amacrine Cells/pathology ; Animals ; CD3 Complex/genetics ; Cell Death ; Dendrites/immunology ; Dendrites/pathology ; Mice, Inbred C57BL ; Mutation ; Nerve Crush ; Optic Nerve/cytology ; Optic Nerve/immunology ; Optic Nerve Injuries/genetics ; Optic Nerve Injuries/immunology ; Retinal Ganglion Cells/cytology ; Retinal Ganglion Cells/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Analysis of Retinal Layer Thicknesses and Their Clinical Correlation in Patients with Traumatic Optic Neuropathy.
Autorzy:
Lee JY; Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Cho K; Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Park KA; Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Oh SY; Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
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Źródło:
PloS one [PLoS One] 2016 Jun 13; Vol. 11 (6), pp. e0157388. Date of Electronic Publication: 2016 Jun 13 (Print Publication: 2016).
Typ publikacji:
Journal Article
MeSH Terms:
Optic Nerve/*diagnostic imaging
Optic Nerve Injuries/*diagnostic imaging
Retina/*diagnostic imaging
Adult ; Color Vision ; Evoked Potentials, Visual ; Female ; Humans ; Male ; Middle Aged ; Optic Nerve/pathology ; Optic Nerve/physiopathology ; Optic Nerve Injuries/pathology ; Optic Nerve Injuries/physiopathology ; Retina/pathology ; Retina/physiopathology ; Tomography, Optical Coherence ; Visual Acuity ; Visual Field Tests ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Alternating Current Stimulation for Vision Restoration after Optic Nerve Damage: A Randomized Clinical Trial.
Autorzy:
Gall C; Institute of Medical Psychology, Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
Schmidt S; Department of Neurology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Schittkowski MP; Department of Ophthalmology, University Medical Center, Georg-August University of Goettingen, Goettingen, Germany.
Antal A; Department of Clinical Neurophysiology, University Medical Center, Georg-August University, Goettingen, Germany.
Ambrus GG; Department of Clinical Neurophysiology, University Medical Center, Georg-August University, Goettingen, Germany.
Paulus W; Department of Clinical Neurophysiology, University Medical Center, Georg-August University, Goettingen, Germany.
Dannhauer M; Center for Integrative Biomedical Computing and the Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, Utah, United States of America.
Michalik R; Institute of Medical Psychology, Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
Mante A; Department of Neurology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Bola M; Institute of Medical Psychology, Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
Lux A; Institute for Biometry and Medical Informatics, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
Kropf S; Institute for Biometry and Medical Informatics, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
Brandt SA; Department of Neurology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Sabel BA; Institute of Medical Psychology, Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
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Źródło:
PloS one [PLoS One] 2016 Jun 29; Vol. 11 (6), pp. e0156134. Date of Electronic Publication: 2016 Jun 29 (Print Publication: 2016).
Typ publikacji:
Journal Article; Multicenter Study; Randomized Controlled Trial
MeSH Terms:
Electric Stimulation Therapy/*methods
Optic Nerve/*physiopathology
Optic Nerve Diseases/*therapy
Optic Nerve Injuries/*therapy
Vision Disorders/*therapy
Adult ; Aged ; Double-Blind Method ; Electricity ; Electroencephalography ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Optic Nerve Diseases/physiopathology ; Optic Nerve Injuries/physiopathology ; Prospective Studies ; Quality of Life ; Self Report ; Time Factors ; Treatment Outcome ; Vision, Ocular ; Visual Acuity ; Visual Field Tests ; Visual Fields
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Injectable, Antioxidative, and Tissue‐Adhesive Nanocomposite Hydrogel as a Potential Treatment for Inner Retina Injuries.
Autorzy:
Liu, Yi‐Chen (AUTHOR)
Lin, Yi‐Ke (AUTHOR)
Lin, Yu‐Ting (AUTHOR)
Lin, Che‐Wei (AUTHOR)
Lan, Guan‐Yu (AUTHOR)
Su, Yu‐Chia (AUTHOR)
Hu, Fung‐Rong (AUTHOR)
Chang, Kai‐Hsiang (AUTHOR)
Chen, Vincent (AUTHOR)
Yeh, Yi‐Cheun (AUTHOR)
Chen, Ta‐Ching (AUTHOR)
Yu, Jiashing (AUTHOR)
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Źródło:
Advanced Science. 3/20/2024, Vol. 11 Issue 11, p1-19. 19p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Optic nerve as a source of activated retinal microglia post-injury.
Autorzy:
Heuss ND; Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN, USA.
Pierson MJ; Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN, USA.
Roehrich H; Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN, USA.
McPherson SW; Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN, USA.
Gram AL; Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN, USA.
Li L; Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN, USA.
Gregerson DS; Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN, USA. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2018 Jul 23; Vol. 6 (1), pp. 66. Date of Electronic Publication: 2018 Jul 23.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Neuroglia/*pathology
Optic Nerve/*metabolism
Optic Nerve/*pathology
Optic Nerve Injuries/*pathology
Retina/*pathology
Animals ; CD11c Antigen/genetics ; CD11c Antigen/metabolism ; CX3C Chemokine Receptor 1/genetics ; CX3C Chemokine Receptor 1/metabolism ; Disease Models, Animal ; Ki-67 Antigen/metabolism ; Leukocyte Common Antigens/metabolism ; Luminescent Proteins/genetics ; Luminescent Proteins/metabolism ; Macrophages/pathology ; Mice ; Mice, Transgenic ; Myeloid Cells ; Optic Chiasm/pathology ; Parabiosis ; Retina/metabolism ; Stilbamidines/metabolism ; Time Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Sirtuin 1 regulates lipid metabolism associated with optic nerve regeneration.
Autorzy:
Zhang Y; Department of Ophthalmology, Chinese PLA General Hospital, Beijing 100085, P.R. China.
Li H; Department of Ophthalmology, Chinese PLA General Hospital, Beijing 100085, P.R. China.
Cao Y; Department of Ophthalmology, International Mongolion Hospital, Hohhot, Inner Mongolia 010065, P.R. China.
Zhang M; Department of Ophthalmology, Chinese PLA General Hospital, Beijing 100085, P.R. China.
Wei S; Department of Ophthalmology, Chinese PLA General Hospital, Beijing 100085, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2015 Nov; Vol. 12 (5), pp. 6962-8. Date of Electronic Publication: 2015 Sep 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Lipid Metabolism*
Nerve Regeneration*
Optic Nerve/*physiopathology
Optic Nerve Injuries/*physiopathology
Sirtuin 1/*metabolism
Animals ; Hydroxymethylglutaryl CoA Reductases/genetics ; Hydroxymethylglutaryl CoA Reductases/metabolism ; Male ; Optic Nerve/metabolism ; Optic Nerve/physiology ; Optic Nerve Injuries/genetics ; Optic Nerve Injuries/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats, Sprague-Dawley ; Sirtuin 1/genetics ; Sterol Regulatory Element Binding Protein 2/genetics ; Sterol Regulatory Element Binding Protein 2/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
An Unexpected Transient Breakdown of the Blood Brain Barrier Triggers Passage of Large Intravenously Administered Nanoparticles.
Autorzy:
Smith NM; Experimental and Regenerative Neurosciences, School of Animal Biology, The University of Western Australia, Perth, WA 6009, Australia.; School of Chemistry and Biochemistry, The University of Western Australia, Perth, WA 6009, Australia.
Gachulincova I; Experimental and Regenerative Neurosciences, School of Animal Biology, The University of Western Australia, Perth, WA 6009, Australia.
Ho D; School of Chemistry and Biochemistry, The University of Western Australia, Perth, WA 6009, Australia.
Bailey C; Experimental and Regenerative Neurosciences, School of Animal Biology, The University of Western Australia, Perth, WA 6009, Australia.
Bartlett CA; Experimental and Regenerative Neurosciences, School of Animal Biology, The University of Western Australia, Perth, WA 6009, Australia.
Norret M; School of Chemistry and Biochemistry, The University of Western Australia, Perth, WA 6009, Australia.
Murphy J; Centre for Microscopy, Characterisation and Analysis, The University of Western Australia, Perth, WA 6009, Australia.
Buckley A; Centre for Microscopy, Characterisation and Analysis, The University of Western Australia, Perth, WA 6009, Australia.
Rigby PJ; Centre for Microscopy, Characterisation and Analysis, The University of Western Australia, Perth, WA 6009, Australia.
House MJ; School of Physics, The University of Western Australia, Perth, WA 6009, Australia.
St Pierre T; School of Physics, The University of Western Australia, Perth, WA 6009, Australia.
Fitzgerald M; Experimental and Regenerative Neurosciences, School of Animal Biology, The University of Western Australia, Perth, WA 6009, Australia.
Iyer KS; School of Chemistry and Biochemistry, The University of Western Australia, Perth, WA 6009, Australia.
Dunlop SA; Experimental and Regenerative Neurosciences, School of Animal Biology, The University of Western Australia, Perth, WA 6009, Australia.
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Źródło:
Scientific reports [Sci Rep] 2016 Mar 04; Vol. 6, pp. 22595. Date of Electronic Publication: 2016 Mar 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Optic Nerve Injuries*
Blood-Brain Barrier/*metabolism
Brain Diseases/*physiopathology
Nanoparticles/*metabolism
Optic Nerve/*pathology
Polymers/*pharmacokinetics
Administration, Intravenous ; Animals ; Biological Transport ; Brain Diseases/surgery ; Disease Models, Animal ; Female ; Humans ; Optic Nerve/surgery ; Rats ; Rats, Inbred Strains ; Tissue Distribution
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Positive effects of bFGF modified rat amniotic epithelial cells transplantation on transected rat optic nerve.
Autorzy:
Xie JX; Department of Anatomy, The Second Military Medical University, Shanghai, P. R. China; Department of Orthopaedics, Changzheng Hospital, The Second Military Medical University, Shanghai, P. R. China; People's Liberation Army Clinical Center for Spinal Cord Injury, Kunming General Hospital of Chengdu Military Command, Kunming, P. R. China.
Feng Y; People's Liberation Army Clinical Center for Spinal Cord Injury, Kunming General Hospital of Chengdu Military Command, Kunming, P. R. China.
Yuan JM; Department of Anatomy, The Second Military Medical University, Shanghai, P. R. China.
You ZD; Department of Neurobiology, The Second Military Medical University, Shanghai, P. R. China.
Lin HY; Department of Anatomy, The Second Military Medical University, Shanghai, P. R. China.
Lu CL; Department of Neurobiology, The Second Military Medical University, Shanghai, P. R. China.
Xu JJ; Department of Anatomy, The Second Military Medical University, Shanghai, P. R. China.
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Źródło:
PloS one [PLoS One] 2015 Mar 03; Vol. 10 (3), pp. e0119119. Date of Electronic Publication: 2015 Mar 03 (Print Publication: 2015).
Typ publikacji:
Journal Article
MeSH Terms:
Epithelial Cells/*transplantation
Fibroblast Growth Factor 2/*genetics
Nerve Regeneration/*physiology
Optic Nerve/*metabolism
Optic Nerve Injuries/*therapy
Amnion/cytology ; Animals ; Biomarkers/metabolism ; Cell Count ; Cell Differentiation ; Cell Survival ; Epithelial Cells/cytology ; Epithelial Cells/metabolism ; Fibroblast Growth Factor 2/metabolism ; GAP-43 Protein/genetics ; GAP-43 Protein/metabolism ; Gene Expression ; Genetic Vectors ; Humans ; Lentivirus/genetics ; Male ; Optic Nerve/pathology ; Optic Nerve/surgery ; Optic Nerve Injuries/metabolism ; Optic Nerve Injuries/pathology ; Rats ; Rats, Sprague-Dawley ; Retinal Ganglion Cells/cytology ; Retinal Ganglion Cells/metabolism ; Transduction, Genetic ; Transgenes
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 349

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