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Wyszukujesz frazę ""ORAI1 Protein"" wg kryterium: Temat


Tytuł :
STIM2 targets Orai1/STIM1 to the AKAP79 signaling complex and confers coupling of Ca entry with NFAT1 activation.
Autorzy :
Son GY; Secretory Physiology Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892.
Subedi KP; Secretory Physiology Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892.
Ong HL; Secretory Physiology Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892.
Noyer L; Department of Pathology, New York University School of Medicine, New York, NY 10016.
Saadi H; Secretory Physiology Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892.
Zheng C; Translational Research Core, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892.
Bhardwaj R; Department of Nephrology and Hypertension, University Hospital Bern, Inselspital, 3010 Bern, Switzerland.
Feske S; Department of Pathology, New York University School of Medicine, New York, NY 10016.
Ambudkar IS; Secretory Physiology Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Jul 14; Vol. 117 (28), pp. 16638-16648. Date of Electronic Publication: 2020 Jun 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
MeSH Terms :
A Kinase Anchor Proteins/*metabolism
Calcium/*metabolism
NFATC Transcription Factors/*metabolism
Neoplasm Proteins/*metabolism
ORAI1 Protein/*metabolism
Stromal Interaction Molecule 1/*metabolism
Stromal Interaction Molecule 2/*metabolism
A Kinase Anchor Proteins/genetics ; Cell Membrane/genetics ; Cell Membrane/metabolism ; Endoplasmic Reticulum/genetics ; Endoplasmic Reticulum/metabolism ; HEK293 Cells ; Humans ; NFATC Transcription Factors/genetics ; Neoplasm Proteins/genetics ; ORAI1 Protein/genetics ; Protein Binding ; Signal Transduction ; Stromal Interaction Molecule 1/genetics ; Stromal Interaction Molecule 2/genetics
Czasopismo naukowe
Tytuł :
Orai calcium release-activated calcium modulator 1 (ORAI1) plays a role in endoplasmic reticulum stress in bovine mammary epithelial cells challenged with physiological levels of ketone bodies.
Autorzy :
Zhang B; College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Xinyang Rd. 2, Daqing, 163319, Heilongjiang, China.
Li M; College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Xinyang Rd. 2, Daqing, 163319, Heilongjiang, China.
Yang W; College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Xinyang Rd. 2, Daqing, 163319, Heilongjiang, China.
Loor JJ; Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois, Urbana 61801.
Wang S; College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Xinyang Rd. 2, Daqing, 163319, Heilongjiang, China.
Zhao Y; College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Xinyang Rd. 2, Daqing, 163319, Heilongjiang, China.
Guo H; College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Xinyang Rd. 2, Daqing, 163319, Heilongjiang, China.
Ma X; College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Xinyang Rd. 2, Daqing, 163319, Heilongjiang, China.
Xia C; College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Xinyang Rd. 2, Daqing, 163319, Heilongjiang, China.
Xu C; College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Xinyang Rd. 2, Daqing, 163319, Heilongjiang, China. Electronic address: .
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Źródło :
Journal of dairy science [J Dairy Sci] 2020 May; Vol. 103 (5), pp. 4691-4701. Date of Electronic Publication: 2020 Mar 12.
Typ publikacji :
Journal Article
MeSH Terms :
Calcium Signaling*
3-Hydroxybutyric Acid/*administration & dosage
Cattle/*physiology
Ketone Bodies/*adverse effects
Ketosis/*veterinary
Milk/*metabolism
ORAI1 Protein/*metabolism
3-Hydroxybutyric Acid/blood ; Animals ; Calcium/metabolism ; Endoplasmic Reticulum Stress ; Epithelial Cells/metabolism ; Female ; Lactation ; Lipid Metabolism ; Lipogenesis ; Liver/metabolism ; Mammary Glands, Animal/metabolism ; ORAI1 Protein/genetics
Czasopismo naukowe
Tytuł :
TRIC-A shapes oscillatory Ca2+ signals by interaction with STIM1/Orai1 complexes.
Autorzy :
Shrestha N; Gottfried Schatz Research Center-Biophysics, Medical University of Graz, Graz, Austria.
Bacsa B; Gottfried Schatz Research Center-Biophysics, Medical University of Graz, Graz, Austria.
Ong HL; Secretory Physiology Section, NIDCR, NIH, Bethesda, Maryland, United States of America.
Scheruebel S; Gottfried Schatz Research Center-Biophysics, Medical University of Graz, Graz, Austria.
Bischof H; Gottfried Schatz Research Center-Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
Malli R; Gottfried Schatz Research Center-Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
Ambudkar IS; Secretory Physiology Section, NIDCR, NIH, Bethesda, Maryland, United States of America.
Groschner K; Gottfried Schatz Research Center-Biophysics, Medical University of Graz, Graz, Austria.
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Źródło :
PLoS biology [PLoS Biol] 2020 Apr 24; Vol. 18 (4), pp. e3000700. Date of Electronic Publication: 2020 Apr 24 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Ion Channels/*metabolism
Neoplasm Proteins/*metabolism
ORAI1 Protein/*metabolism
Stromal Interaction Molecule 1/*metabolism
Animals ; Calcium Signaling/physiology ; Cell Membrane/metabolism ; Endoplasmic Reticulum/metabolism ; HEK293 Cells ; Humans ; Male ; Mice, Inbred C57BL ; Multiprotein Complexes/metabolism ; Neoplasm Proteins/genetics ; ORAI1 Protein/genetics ; Patch-Clamp Techniques ; Ryanodine Receptor Calcium Release Channel/metabolism ; Stromal Interaction Molecule 1/genetics
Czasopismo naukowe
Tytuł :
Orai1 Channel Inhibition Preserves Left Ventricular Systolic Function and Normal Ca Handling After Pressure Overload.
Autorzy :
Bartoli F; Inserm, UMR-S 1180, Signalisation et Physiopathologie Cardiovasculaire, Université Paris-Saclay, Châtenay-Malabry, France (F.B., P.M., K.B., P.G., S.G., F.L., A.-M.G., J.P.B., J. Sabourin).
Bailey MA; Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, United Kingdom (M.A.B., B.R., J.F.X.A., M.T.K., A.-F.B., J. Shi, H.L.A., R.S.Y., H.M.S., M.D., D.J.B.).
Rode B; Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, United Kingdom (M.A.B., B.R., J.F.X.A., M.T.K., A.-F.B., J. Shi, H.L.A., R.S.Y., H.M.S., M.D., D.J.B.).
Mateo P; Inserm, UMR-S 1180, Signalisation et Physiopathologie Cardiovasculaire, Université Paris-Saclay, Châtenay-Malabry, France (F.B., P.M., K.B., P.G., S.G., F.L., A.-M.G., J.P.B., J. Sabourin).
Antigny F; Inserm, UMR-S 999, Université Paris-Saclay, Centre Chirurgical Marie Lannelongue, Le Plessis-Robinson, France (F.A., C.R.M.).
Bedouet K; Inserm, UMR-S 1180, Signalisation et Physiopathologie Cardiovasculaire, Université Paris-Saclay, Châtenay-Malabry, France (F.B., P.M., K.B., P.G., S.G., F.L., A.-M.G., J.P.B., J. Sabourin).
Gerbaud P; Inserm, UMR-S 1180, Signalisation et Physiopathologie Cardiovasculaire, Université Paris-Saclay, Châtenay-Malabry, France (F.B., P.M., K.B., P.G., S.G., F.L., A.-M.G., J.P.B., J. Sabourin).
Gosain R; School of Chemistry, University of Leeds, United Kingdom (R.G., J.P., K.N., R.F.).
Plante J; School of Chemistry, University of Leeds, United Kingdom (R.G., J.P., K.N., R.F.).
Norman K; School of Chemistry, University of Leeds, United Kingdom (R.G., J.P., K.N., R.F.).
Gomez S; Inserm, UMR-S 1180, Signalisation et Physiopathologie Cardiovasculaire, Université Paris-Saclay, Châtenay-Malabry, France (F.B., P.M., K.B., P.G., S.G., F.L., A.-M.G., J.P.B., J. Sabourin).
Lefebvre F; Inserm, UMR-S 1180, Signalisation et Physiopathologie Cardiovasculaire, Université Paris-Saclay, Châtenay-Malabry, France (F.B., P.M., K.B., P.G., S.G., F.L., A.-M.G., J.P.B., J. Sabourin).
Rucker-Martin C; Inserm, UMR-S 999, Université Paris-Saclay, Centre Chirurgical Marie Lannelongue, Le Plessis-Robinson, France (F.A., C.R.M.).
Ainscough JFX; Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, United Kingdom (M.A.B., B.R., J.F.X.A., M.T.K., A.-F.B., J. Shi, H.L.A., R.S.Y., H.M.S., M.D., D.J.B.).
Kearney MT; Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, United Kingdom (M.A.B., B.R., J.F.X.A., M.T.K., A.-F.B., J. Shi, H.L.A., R.S.Y., H.M.S., M.D., D.J.B.).
Bruns AF; Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, United Kingdom (M.A.B., B.R., J.F.X.A., M.T.K., A.-F.B., J. Shi, H.L.A., R.S.Y., H.M.S., M.D., D.J.B.).
Shi J; Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, United Kingdom (M.A.B., B.R., J.F.X.A., M.T.K., A.-F.B., J. Shi, H.L.A., R.S.Y., H.M.S., M.D., D.J.B.).
Appleby HL; Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, United Kingdom (M.A.B., B.R., J.F.X.A., M.T.K., A.-F.B., J. Shi, H.L.A., R.S.Y., H.M.S., M.D., D.J.B.).
Young RS; Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, United Kingdom (M.A.B., B.R., J.F.X.A., M.T.K., A.-F.B., J. Shi, H.L.A., R.S.Y., H.M.S., M.D., D.J.B.).
Shawer HM; Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, United Kingdom (M.A.B., B.R., J.F.X.A., M.T.K., A.-F.B., J. Shi, H.L.A., R.S.Y., H.M.S., M.D., D.J.B.).
Debant M; Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, United Kingdom (M.A.B., B.R., J.F.X.A., M.T.K., A.-F.B., J. Shi, H.L.A., R.S.Y., H.M.S., M.D., D.J.B.).
Gomez AM; Inserm, UMR-S 1180, Signalisation et Physiopathologie Cardiovasculaire, Université Paris-Saclay, Châtenay-Malabry, France (F.B., P.M., K.B., P.G., S.G., F.L., A.-M.G., J.P.B., J. Sabourin).
Beech DJ; Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, United Kingdom (M.A.B., B.R., J.F.X.A., M.T.K., A.-F.B., J. Shi, H.L.A., R.S.Y., H.M.S., M.D., D.J.B.).
Foster R; School of Chemistry, University of Leeds, United Kingdom (R.G., J.P., K.N., R.F.).
Benitah JP; Inserm, UMR-S 1180, Signalisation et Physiopathologie Cardiovasculaire, Université Paris-Saclay, Châtenay-Malabry, France (F.B., P.M., K.B., P.G., S.G., F.L., A.-M.G., J.P.B., J. Sabourin).
Sabourin J; Inserm, UMR-S 1180, Signalisation et Physiopathologie Cardiovasculaire, Université Paris-Saclay, Châtenay-Malabry, France (F.B., P.M., K.B., P.G., S.G., F.L., A.-M.G., J.P.B., J. Sabourin).
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Źródło :
Circulation [Circulation] 2020 Jan 21; Vol. 141 (3), pp. 199-216. Date of Electronic Publication: 2020 Jan 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium Signaling*
Ventricular Function, Left*
Calcium/*metabolism
Cardiomegaly/*metabolism
Myocytes, Cardiac/*metabolism
ORAI1 Protein/*antagonists & inhibitors
ORAI1 Protein/*metabolism
Animals ; Cardiomegaly/genetics ; Cardiomegaly/pathology ; Focal Adhesion Kinase 2/genetics ; Focal Adhesion Kinase 2/metabolism ; Mice ; Mice, Transgenic ; Myocytes, Cardiac/pathology ; ORAI1 Protein/genetics ; Sarcoplasmic Reticulum Calcium-Transporting ATPases/genetics ; Sarcoplasmic Reticulum Calcium-Transporting ATPases/metabolism
Czasopismo naukowe
Tytuł :
Ca -Dependent Inactivation of the Orai1 Channel.
Autorzy :
Bhardwaj R; Membrane Transport Discovery Lab, Department of Nephrology and Hypertension, Inselspital Bern, Bern, Switzerland, .; Department of Biomedical Research, University of Bern, Bern, Switzerland.
Augustynek BS; Membrane Transport Discovery Lab, Department of Nephrology and Hypertension, Inselspital Bern, Bern, Switzerland.; Department of Biomedical Research, University of Bern, Bern, Switzerland.
Ercan-Herbst E; BioMed X Innovation Center, Heidelberg, Germany.; Center for Molecular Biology, University of Heidelberg, Heidelberg, Germany.
Kandasamy P; Membrane Transport Discovery Lab, Department of Nephrology and Hypertension, Inselspital Bern, Bern, Switzerland.; Department of Biomedical Research, University of Bern, Bern, Switzerland.
Seedorf M; Center for Molecular Biology, University of Heidelberg, Heidelberg, Germany.
Peinelt C; Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland.
Hediger MA; Membrane Transport Discovery Lab, Department of Nephrology and Hypertension, Inselspital Bern, Bern, Switzerland, .; Department of Biomedical Research, University of Bern, Bern, Switzerland.
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Źródło :
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology [Cell Physiol Biochem] 2020 Mar 17; Vol. 54 (2), pp. 252-270.
Typ publikacji :
Journal Article
MeSH Terms :
Calcium/*metabolism
Calcium Channels/*metabolism
Calmodulin/*metabolism
Neoplasm Proteins/*chemistry
Neoplasm Proteins/*physiology
ORAI1 Protein/*metabolism
Stromal Interaction Molecule 1/*chemistry
Stromal Interaction Molecule 1/*physiology
CRISPR-Cas Systems ; Calcium Channels/genetics ; Calcium Signaling ; Gene Knockout Techniques ; HEK293 Cells ; Humans ; Hydrophobic and Hydrophilic Interactions ; Membrane Proteins/metabolism ; Models, Chemical ; Models, Molecular ; Mutation ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; ORAI1 Protein/chemistry ; ORAI1 Protein/genetics ; Protein Binding ; Protein Domains ; Stromal Interaction Molecule 1/genetics ; Stromal Interaction Molecule 1/metabolism ; Up-Regulation
Czasopismo naukowe
Tytuł :
Reversal of phosphate-induced ORAI1 expression, store-operated Ca entry and osteogenic signaling by MgCl 2 in human aortic smooth muscle cells.
Autorzy :
Zhu X; Department of Pharmacology, Experimental Therapy & Toxicology, Eberhard-Karls-University of Tübingen, Germany.
Ma K; Department of Pharmacology, Experimental Therapy & Toxicology, Eberhard-Karls-University of Tübingen, Germany.
Zhou K; Department of Pharmacology, Experimental Therapy & Toxicology, Eberhard-Karls-University of Tübingen, Germany.
Voelkl J; Institute for Physiology, Johannes-Kepler-University Linz, Austria.
Alesutan I; Institute for Physiology, Johannes-Kepler-University Linz, Austria.
Leibrock C; Fresenius Kabi, Oberursel, Germany.
Nürnberg B; Department of Pharmacology, Experimental Therapy & Toxicology, Eberhard-Karls-University of Tübingen, Germany.
Lang F; Department of Physiology, Eberhard-Karls-University, Tübingen, Germany. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Feb 26; Vol. 523 (1), pp. 18-24. Date of Electronic Publication: 2019 Dec 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium/*metabolism
Magnesium Chloride/*pharmacology
Myocytes, Smooth Muscle/*drug effects
ORAI1 Protein/*biosynthesis
Osteogenesis/*drug effects
Signal Transduction/*drug effects
Cells, Cultured ; Gadolinium/pharmacology ; Humans ; Myocytes, Smooth Muscle/metabolism ; ORAI1 Protein/genetics ; ORAI1 Protein/metabolism
Czasopismo naukowe
Tytuł :
Modulation of Orai1 by cationic peptides triggers their direct cytosolic uptake.
Autorzy :
Zuconelli CR; Department of Biochemistry (286), Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA Nijmegen, the Netherlands; CAPES Foundation, Ministry of Education of Brazil, Brasília, DF 70040-020, Brazil.
Schmidt S; Department of Biochemistry (286), Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA Nijmegen, the Netherlands.
Wallbrecher R; Department of Biochemistry (286), Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA Nijmegen, the Netherlands.
van Oostrum J; Department of Biochemistry (286), Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA Nijmegen, the Netherlands.
Bartels YL; Department of Biochemistry (286), Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA Nijmegen, the Netherlands.
Didan Y; Department of Biochemistry (286), Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA Nijmegen, the Netherlands.
Berendsen MLT; Department of Biochemistry (286), Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA Nijmegen, the Netherlands.
Brock R; Department of Biochemistry (286), Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA Nijmegen, the Netherlands.
Adjobo-Hermans MJW; Department of Biochemistry (286), Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA Nijmegen, the Netherlands. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Biomembranes [Biochim Biophys Acta Biomembr] 2020 Mar 01; Vol. 1862 (3), pp. 183155. Date of Electronic Publication: 2019 Dec 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell-Penetrating Peptides/*metabolism
ORAI1 Protein/*metabolism
Calcium/metabolism ; Calcium Channels/metabolism ; Calcium Signaling/physiology ; Cations/metabolism ; Cell Membrane/metabolism ; Cell-Penetrating Peptides/physiology ; Cytosol ; HeLa Cells ; Humans ; ORAI1 Protein/physiology ; Sphingomyelin Phosphodiesterase/metabolism ; Thapsigargin/pharmacology
Czasopismo naukowe
Tytuł :
Oxidative stress facilitates cell death by inhibiting Orai1-mediated Ca entry in brain capillary endothelial cells.
Autorzy :
Yamamura H; Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabedori Mizuhoku, Nagoya, 467-8603, Japan.
Suzuki Y; Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabedori Mizuhoku, Nagoya, 467-8603, Japan.
Asai K; Department of Molecular Neurobiology, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi Mizuhocho Mizuhoku, Nagoya, 467-8601, Japan.
Imaizumi Y; Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabedori Mizuhoku, Nagoya, 467-8603, Japan.
Yamamura H; Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabedori Mizuhoku, Nagoya, 467-8603, Japan. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Feb 26; Vol. 523 (1), pp. 153-158. Date of Electronic Publication: 2019 Dec 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Oxidative Stress*/drug effects
Acetylcysteine/*pharmacology
Calcium/*metabolism
Endothelial Cells/*drug effects
ORAI1 Protein/*antagonists & inhibitors
Animals ; Blood-Brain Barrier/drug effects ; Blood-Brain Barrier/metabolism ; Cattle ; Cell Death/drug effects ; Cell Proliferation/drug effects ; Cells, Cultured ; Endothelial Cells/metabolism ; Hydrogen Peroxide/antagonists & inhibitors ; Hydrogen Peroxide/pharmacology ; ORAI1 Protein/metabolism
Czasopismo naukowe
Tytuł :
Transgenic Mice Overexpressing Human STIM2 and ORAI1 in Neurons Exhibit Changes in Behavior and Calcium Homeostasis but Show No Signs of Neurodegeneration.
Autorzy :
Majewski L; International Institute of Molecular and Cell Biology in Warsaw, 4 Ksiecia Trojdena Str., 02-109 Warsaw, Poland.
Maciąg F; International Institute of Molecular and Cell Biology in Warsaw, 4 Ksiecia Trojdena Str., 02-109 Warsaw, Poland.; Postgraduate School of Molecular Medicine, Warsaw Medical University, 61 Żwirki i Wigury St., 02-091 Warsaw, Poland.
Boguszewski PM; Laboratory of Animal Models, Neurobiology Centre, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 3 Pasteur Str., 02-093 Warsaw, Poland.
Kuznicki J; International Institute of Molecular and Cell Biology in Warsaw, 4 Ksiecia Trojdena Str., 02-109 Warsaw, Poland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Jan 28; Vol. 21 (3). Date of Electronic Publication: 2020 Jan 28.
Typ publikacji :
Journal Article
MeSH Terms :
Behavior/*physiology
Calcium/*metabolism
Neurons/*metabolism
ORAI1 Protein/*genetics
Stromal Interaction Molecule 2/*genetics
Animals ; Behavior Rating Scale ; Cytosol/metabolism ; Female ; Homeostasis ; Humans ; Male ; Mice ; Mice, Transgenic ; ORAI1 Protein/metabolism ; Stromal Interaction Molecule 2/metabolism
Czasopismo naukowe
Tytuł :
Orai-1 and Orai-2 regulate oral cancer cell migration and colonisation by suppressing Akt/mTOR/NF-κB signalling.
Autorzy :
Singh AK; Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam 781039, India.
Roy NK; Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam 781039, India.
Bordoloi D; Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam 781039, India.
Padmavathi G; Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam 781039, India.
Banik K; Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam 781039, India.
Khwairakpam AD; Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam 781039, India.
Kunnumakkara AB; Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam 781039, India. Electronic address: .
Sukumar P; Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds LS2 9JT, UK. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Nov 15; Vol. 261, pp. 118372. Date of Electronic Publication: 2020 Aug 31.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Movement*/drug effects
Signal Transduction*/drug effects
Mouth Neoplasms/*pathology
NF-kappa B/*metabolism
ORAI1 Protein/*metabolism
ORAI2 Protein/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
TOR Serine-Threonine Kinases/*metabolism
Calcium/metabolism ; Calcium Signaling ; Carcinogens/toxicity ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Silencing/drug effects ; Humans ; Mouth Neoplasms/genetics ; Tobacco/chemistry ; Tumor Stem Cell Assay
Czasopismo naukowe
Tytuł :
Crbn modulates calcium influx by regulating Orai1 during efferocytosis.
Autorzy :
Moon H; School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Korea.; Cell Mechanobiology Laboratory, Gwangju Institute of Science and Technology, Gwangju, 61005, Korea.
Min C; School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Korea.; Cell Mechanobiology Laboratory, Gwangju Institute of Science and Technology, Gwangju, 61005, Korea.
Kim G; School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Korea.
Kim D; School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Korea.; Cell Mechanobiology Laboratory, Gwangju Institute of Science and Technology, Gwangju, 61005, Korea.
Kim K; School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Korea.; Cell Mechanobiology Laboratory, Gwangju Institute of Science and Technology, Gwangju, 61005, Korea.
Lee SA; School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Korea.; Cell Mechanobiology Laboratory, Gwangju Institute of Science and Technology, Gwangju, 61005, Korea.
Moon B; School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Korea.; Cell Mechanobiology Laboratory, Gwangju Institute of Science and Technology, Gwangju, 61005, Korea.
Yang S; School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Korea.; Cell Mechanobiology Laboratory, Gwangju Institute of Science and Technology, Gwangju, 61005, Korea.
Lee J; School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Korea.; Cell Mechanobiology Laboratory, Gwangju Institute of Science and Technology, Gwangju, 61005, Korea.
Yang SJ; School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Korea.
Cho SK; School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Korea.
Lee G; School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Korea.; Cell Mechanobiology Laboratory, Gwangju Institute of Science and Technology, Gwangju, 61005, Korea.
Lee CS; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju, 52828, Korea.
Park CS; School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Korea.
Park D; School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Korea. .; Cell Mechanobiology Laboratory, Gwangju Institute of Science and Technology, Gwangju, 61005, Korea. .; Research Center for Cellular Homeostasis, Ewha Womans University, Seoul, 03760, Korea. .
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Źródło :
Nature communications [Nat Commun] 2020 Oct 30; Vol. 11 (1), pp. 5489. Date of Electronic Publication: 2020 Oct 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing/*metabolism
Calcium/*metabolism
ORAI1 Protein/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Adaptor Proteins, Signal Transducing/genetics ; Animals ; Apoptosis ; Calcium Channels/metabolism ; Calcium Signaling ; Cell Death ; HEK293 Cells ; Humans ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Phagocytosis ; Ubiquitin-Protein Ligases/genetics
Czasopismo naukowe
Tytuł :
Orai1 Promotes Osteosarcoma Metastasis by Activating the Ras-Rac1-WAVE2 Signaling Pathway.
Autorzy :
Guo Y; Department of Spinal Surgery, Hong Hui Hospital, Xi'an Jiao Tong University, Xi'an, Shaanxi, China (mainland).
Zhu J; Department of Spinal Surgery, Hong Hui Hospital, Xi'an Jiao Tong University, Xi'an, Shaanxi, China (mainland).
Wang X; Department of Spinal Surgery, Hong Hui Hospital, Xi'an Jiao Tong University, Xi'an, Shaanxi, China (mainland).
Li R; Department of Spinal Surgery, Hong Hui Hospital, Xi'an Jiao Tong University, Xi'an, Shaanxi, China (mainland).
Jiang K; Department of Spinal Surgery, Hong Hui Hospital, Xi'an Jiao Tong University, Xi'an, Shaanxi, China (mainland).
Chen S; Department of Emergency Medicine, Hong Hui Hospital, Xi'an Jiao Tong University, Xi'an, Shaanxi, China (mainland).
Fan J; Department of Orthopedics, Hong Hui Hospital, Xi'an Jiao Tong University, Xi'an, Shaanxi, China (mainland).
Xue L; Department of Spinal Surgery, Hong Hui Hospital, Xi'an Jiao Tong University, Xi'an, Shaanxi, China (mainland).
Hao D; Department of Spinal Surgery, Hong Hui Hospital, Xi'an Jiao Tong University, Xi'an, Shaanxi, China (mainland).
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Źródło :
Medical science monitor : international medical journal of experimental and clinical research [Med Sci Monit] 2019 Dec 04; Vol. 25, pp. 9227-9236. Date of Electronic Publication: 2019 Dec 04.
Typ publikacji :
Journal Article
MeSH Terms :
Bone Neoplasms/*metabolism
ORAI1 Protein/*metabolism
Osteosarcoma/*metabolism
Wiskott-Aldrich Syndrome Protein Family/*metabolism
rac1 GTP-Binding Protein/*metabolism
ras Proteins/*metabolism
Antineoplastic Agents/pharmacology ; Bone Neoplasms/drug therapy ; Bone Neoplasms/genetics ; Bone Neoplasms/pathology ; Cell Adhesion/genetics ; Cell Line, Tumor ; Cell Movement/genetics ; Humans ; Neoplasm Invasiveness ; Neoplasm Metastasis ; ORAI1 Protein/genetics ; Osteosarcoma/drug therapy ; Osteosarcoma/genetics ; Osteosarcoma/pathology ; RNA, Small Interfering/pharmacology ; Signal Transduction ; Wiskott-Aldrich Syndrome Protein Family/genetics ; rac1 GTP-Binding Protein/genetics ; ras Proteins/genetics
Czasopismo naukowe
Tytuł :
The regulatory roles of calcium channels in tumors.
Autorzy :
Zhong T; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, PR China.
Pan X; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, PR China.
Wang J; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, PR China.
Yang B; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, PR China. Electronic address: .
Ding L; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, PR China. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2019 Nov; Vol. 169, pp. 113603. Date of Electronic Publication: 2019 Aug 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Calcium Signaling*
Calcium/*metabolism
Calcium Release Activated Calcium Channels/*metabolism
Neoplasms/*metabolism
ORAI1 Protein/*metabolism
Animals ; Calcium Channel Blockers/pharmacology ; Calcium Channel Blockers/therapeutic use ; Calcium Release Activated Calcium Channels/antagonists & inhibitors ; Calcium-Transporting ATPases/antagonists & inhibitors ; Carcinogenesis/metabolism ; Drug Resistance, Multiple ; Drug Resistance, Neoplasm ; Humans ; Neoplasms/drug therapy ; ORAI1 Protein/antagonists & inhibitors ; Transient Receptor Potential Channels/antagonists & inhibitors ; Transient Receptor Potential Channels/metabolism ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Mibefradil, a T-type Ca channel blocker also blocks Orai channels by action at the extracellular surface.
Autorzy :
Li P; Centre for Atherothrombosis and Metabolic Disease, Hull York Medical School, University of Hull, Hull, UK.; Key Laboratory of Medical Electrophysiology, Ministry of Education, and Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China.
Rubaiy HN; Centre for Atherothrombosis and Metabolic Disease, Hull York Medical School, University of Hull, Hull, UK.
Chen GL; Centre for Atherothrombosis and Metabolic Disease, Hull York Medical School, University of Hull, Hull, UK.; Key Laboratory of Medical Electrophysiology, Ministry of Education, and Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China.
Hallett T; Centre for Atherothrombosis and Metabolic Disease, Hull York Medical School, University of Hull, Hull, UK.
Zaibi N; Centre for Atherothrombosis and Metabolic Disease, Hull York Medical School, University of Hull, Hull, UK.
Zeng B; Key Laboratory of Medical Electrophysiology, Ministry of Education, and Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China.
Saurabh R; Centre for Atherothrombosis and Metabolic Disease, Hull York Medical School, University of Hull, Hull, UK.
Xu SZ; Centre for Atherothrombosis and Metabolic Disease, Hull York Medical School, University of Hull, Hull, UK.
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Źródło :
British journal of pharmacology [Br J Pharmacol] 2019 Oct; Vol. 176 (19), pp. 3845-3856. Date of Electronic Publication: 2019 Aug 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium Channel Blockers/*pharmacology
Calcium Channels/*metabolism
Mibefradil/*pharmacology
ORAI1 Protein/*antagonists & inhibitors
ORAI2 Protein/*antagonists & inhibitors
Calcium/analysis ; Calcium/metabolism ; Calcium Channel Blockers/chemistry ; Cell Death/drug effects ; Cell Proliferation/drug effects ; Cells, Cultured ; HEK293 Cells ; Humans ; Mibefradil/chemistry ; ORAI1 Protein/metabolism ; ORAI2 Protein/metabolism ; Optical Imaging
Czasopismo naukowe
Tytuł :
Mechanistic insights into the Orai channel by molecular dynamics simulations.
Autorzy :
Bonhenry D; Center for Nanobiology and Structural Biology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Nové Hrady CZ-373 33, Czech Republic. Electronic address: .
Schober R; Institute for Biophysics, Johannes Kepler University Linz, A-4040 Linz, Austria.
Schmidt T; Gottfried Schatz Research Center, Medical University of Graz, A-8010 Graz, Austria.
Waldherr L; Gottfried Schatz Research Center, Medical University of Graz, A-8010 Graz, Austria.
Ettrich RH; Center for Nanobiology and Structural Biology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Nové Hrady CZ-373 33, Czech Republic; College of Biomedical Sciences, Larkin University, Miami, FL 33169, United States.
Schindl R; Gottfried Schatz Research Center, Medical University of Graz, A-8010 Graz, Austria. Electronic address: .
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Źródło :
Seminars in cell & developmental biology [Semin Cell Dev Biol] 2019 Oct; Vol. 94, pp. 50-58. Date of Electronic Publication: 2019 Jan 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Molecular Dynamics Simulation*
Calcium/*metabolism
ORAI1 Protein/*metabolism
Humans ; Neoplasm Proteins/chemistry ; Neoplasm Proteins/metabolism ; ORAI1 Protein/chemistry ; Stromal Interaction Molecule 1/chemistry ; Stromal Interaction Molecule 1/metabolism
Czasopismo naukowe
Tytuł :
Phosphate-induced ORAI1 expression and store-operated Ca entry in aortic smooth muscle cells.
Autorzy :
Ma K; Department of Pharmacology & Experimental Therapy, University of Tübingen, 72076, Tübingen, Germany.
Liu P; Department of Pharmacology & Experimental Therapy, University of Tübingen, 72076, Tübingen, Germany.
Al-Maghout T; Department of Pharmacology & Experimental Therapy, University of Tübingen, 72076, Tübingen, Germany.
Sukkar B; Department of Pharmacology & Experimental Therapy, University of Tübingen, 72076, Tübingen, Germany.
Cao H; Department of Pharmacology & Experimental Therapy, University of Tübingen, 72076, Tübingen, Germany.
Voelkl J; Institute for Physiology and Pathophysiology, Johannes Kepler University Linz, 4040, Linz, Austria.; Department of Internal Medicine and Cardiology, Charité University Medicine, Campus Virchow-Klinikum, Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site, Berlin, Germany.; Department of Nephrology and Medical Intensive Care, Charité University Medicine, Berlin, Germany.
Alesutan I; Institute for Physiology and Pathophysiology, Johannes Kepler University Linz, 4040, Linz, Austria.; Department of Internal Medicine and Cardiology, Charité University Medicine, Campus Virchow-Klinikum, Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site, Berlin, Germany.; Berlin Institute of Health (BIH), Berlin, Germany.
Pieske B; Department of Internal Medicine and Cardiology, Charité University Medicine, Campus Virchow-Klinikum, Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site, Berlin, Germany.; Berlin Institute of Health (BIH), Berlin, Germany.; Department of Internal Medicine and Cardiology, German Heart Center Berlin (DHZB), Berlin, Germany.
Lang F; Department of Vegetative and Clinical Physiology, University of Tübingen, Wilhelmstr. 56, 72074, Tübingen, Germany. .
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Źródło :
Journal of molecular medicine (Berlin, Germany) [J Mol Med (Berl)] 2019 Oct; Vol. 97 (10), pp. 1465-1475. Date of Electronic Publication: 2019 Aug 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium/*metabolism
Myocytes, Smooth Muscle/*metabolism
ORAI1 Protein/*metabolism
Vascular Calcification/*metabolism
Alkaline Phosphatase/genetics ; Alkaline Phosphatase/metabolism ; Animals ; Aorta/cytology ; Cell Transdifferentiation/genetics ; Cells, Cultured ; Gene Expression ; Glycerophosphates/metabolism ; Humans ; Muscle, Smooth, Vascular/cytology ; Myocytes, Smooth Muscle/cytology ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; ORAI1 Protein/genetics ; SOX9 Transcription Factor/genetics ; SOX9 Transcription Factor/metabolism ; Stromal Interaction Molecule 1/genetics ; Stromal Interaction Molecule 1/metabolism ; Vascular Calcification/genetics
Czasopismo naukowe
Tytuł :
Coupling of store-operated calcium entry to vasoconstriction is acid-sensing ion channel 1a dependent in pulmonary but not mesenteric arteries.
Autorzy :
Garcia SM; Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States of America.
Herbert LM; Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States of America.
Walker BR; Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States of America.
Resta TC; Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States of America.
Jernigan NL; Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Jul 23; Vol. 15 (7), pp. e0236288. Date of Electronic Publication: 2020 Jul 23 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Vasoconstriction*
Acid Sensing Ion Channels/*metabolism
Calcium/*metabolism
Mesenteric Arteries/*physiology
Pulmonary Artery/*physiology
Acid Sensing Ion Channels/genetics ; Animals ; Calcium Channels, L-Type/metabolism ; Endothelin-1/pharmacology ; Male ; Mesenteric Arteries/drug effects ; Muscle, Smooth, Vascular/cytology ; Myocytes, Smooth Muscle/drug effects ; Myocytes, Smooth Muscle/metabolism ; ORAI1 Protein/genetics ; ORAI1 Protein/metabolism ; Protein Binding/drug effects ; Pulmonary Artery/drug effects ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats, Wistar ; Stromal Interaction Molecule 1/metabolism
Czasopismo naukowe
Tytuł :
Tspan18 is a novel regulator of the Ca channel Orai1 and von Willebrand factor release in endothelial cells.
Autorzy :
Noy PJ; School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, UK.
Gavin RL; School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, UK.
Colombo D; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Haining EJ; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Reyat JS; School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, UK.
Payne H; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Thielmann I; University Hospital Würzburg and Rudolf Virchow Center for Experimental Biomedicine, Würzburg, Germany.
Lokman AB; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Neag G; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Yang J; School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, UK.
Lloyd T; School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, UK.
Harrison N; School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, UK.
Heath VL; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Gardiner C; Department of Haematology, University College London, London, UK.
Whitworth KM; Institute of Immunology and Immunotherapy, Cancer Immunology and Immunotherapy Centre, University of Birmingham, Birmingham, UK.
Robinson J; Institute of Immunology and Immunotherapy, Cancer Immunology and Immunotherapy Centre, University of Birmingham, Birmingham, UK.
Koo CZ; School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, UK.
Di Maio A; School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, UK.
Harrison P; Scar Free Foundation for Burns Research, Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham National Health Service (NHS) Foundation Trust, Birmingham, UK.; Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
Lee SP; Institute of Immunology and Immunotherapy, Cancer Immunology and Immunotherapy Centre, University of Birmingham, Birmingham, UK.
Michelangeli F; Department of Biological Sciences, University of Chester, Chester, UK.
Kalia N; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.; Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham-Nottingham, UK.
Rainger GE; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Nieswandt B; University Hospital Würzburg and Rudolf Virchow Center for Experimental Biomedicine, Würzburg, Germany.
Brill A; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.; Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham-Nottingham, UK.; Department of Pathophysiology, Sechenov First Moscow State Medical University, Moscow, Russia.
Watson SP; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.; Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham-Nottingham, UK.
Tomlinson MG; School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, UK .; Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham-Nottingham, UK.
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Źródło :
Haematologica [Haematologica] 2019 Sep; Vol. 104 (9), pp. 1892-1905. Date of Electronic Publication: 2018 Dec 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium/*metabolism
Myocardial Reperfusion Injury/*genetics
ORAI1 Protein/*genetics
Tetraspanins/*genetics
Venous Thrombosis/*genetics
von Willebrand Factor/*genetics
Animals ; B-Lymphocytes/cytology ; B-Lymphocytes/drug effects ; B-Lymphocytes/metabolism ; Chickens ; Disease Models, Animal ; Gene Expression Regulation ; HEK293 Cells ; HeLa Cells ; Histamine/pharmacology ; Human Umbilical Vein Endothelial Cells/cytology ; Human Umbilical Vein Endothelial Cells/drug effects ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Ion Transport/drug effects ; Jurkat Cells ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Myocardial Reperfusion Injury/metabolism ; Myocardial Reperfusion Injury/pathology ; NFATC Transcription Factors/genetics ; NFATC Transcription Factors/metabolism ; ORAI1 Protein/metabolism ; Signal Transduction ; Tetraspanins/metabolism ; Thrombin/pharmacology ; Venous Thrombosis/metabolism ; Venous Thrombosis/pathology ; von Willebrand Factor/metabolism
Czasopismo naukowe
Tytuł :
Effects of ORAI calcium release-activated calcium modulator 1 (ORAI1) on neutrophil activity in dairy cows with subclinical hypocalcemia1.
Autorzy :
Zhang B; College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, China.
Guo H; College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, China.
Yang W; College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, China.
Li M; College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, China.
Zou Y; College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, China.
Loor JJ; Department of Animal Sciences and Division of Nutritional Sciences, Mammalian NutriPhysioGenomics, University of Illinois, Urbana, IL.
Xia C; College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, China.
Xu C; College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, China.
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Źródło :
Journal of animal science [J Anim Sci] 2019 Jul 30; Vol. 97 (8), pp. 3326-3336.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation*
Calcium/*metabolism
Cattle/*genetics
Hypocalcemia/*veterinary
ORAI1 Protein/*metabolism
Animals ; Cattle/immunology ; Cattle/physiology ; Dairying ; Female ; Hypocalcemia/immunology ; Inflammation/veterinary ; Neutrophils/immunology ; ORAI1 Protein/genetics ; Parathyroid Hormone/metabolism ; Phagocytosis ; Postpartum Period ; RNA, Small Interfering ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
STIM1 and Orai1 regulate Ca microdomains for activation of transcription.
Autorzy :
Schober R; Institute for Biophysics, Johannes Kepler University Linz, A-4040 Linz, Austria. Electronic address: .
Waldherr L; Gottfried Schatz Research Center, Medical University of Graz, A-8010 Graz, Austria.
Schmidt T; Gottfried Schatz Research Center, Medical University of Graz, A-8010 Graz, Austria.
Graziani A; Gottfried Schatz Research Center, Medical University of Graz, A-8010 Graz, Austria.
Stilianu C; Gottfried Schatz Research Center, Medical University of Graz, A-8010 Graz, Austria.
Legat L; Gottfried Schatz Research Center, Medical University of Graz, A-8010 Graz, Austria.
Groschner K; Gottfried Schatz Research Center, Medical University of Graz, A-8010 Graz, Austria.
Schindl R; Gottfried Schatz Research Center, Medical University of Graz, A-8010 Graz, Austria. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2019 Jul; Vol. 1866 (7), pp. 1079-1091. Date of Electronic Publication: 2018 Nov 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Autophagy/*physiology
Calcium/*metabolism
Calcium Signaling/*physiology
Neoplasm Proteins/*metabolism
ORAI1 Protein/*metabolism
Stromal Interaction Molecule 1/*metabolism
Transcription, Genetic/*physiology
Animals ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/metabolism ; Endoplasmic Reticulum/genetics ; Endoplasmic Reticulum/metabolism ; Humans ; Microphthalmia-Associated Transcription Factor/genetics ; Microphthalmia-Associated Transcription Factor/metabolism ; NFATC Transcription Factors/genetics ; NFATC Transcription Factors/metabolism ; Neoplasm Proteins/genetics ; ORAI1 Protein/genetics ; Stromal Interaction Molecule 1/genetics
Czasopismo naukowe

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