Temat: "ORAI1 Protein" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Orai1α and Orai1β support calcium entry and mammosphere formation in breast cancer stem cells.
Autorzy:: Jardin I; Department of Physiology (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers (IMPB), Universidad de Extremadura, 10003, Caceres, Spain. .
Alvarado S; Department of Physiology (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers (IMPB), Universidad de Extremadura, 10003, Caceres, Spain.
Jimenez-Velarde V; Department of Physiology (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers (IMPB), Universidad de Extremadura, 10003, Caceres, Spain.
Nieto-Felipe J; Department of Physiology (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers (IMPB), Universidad de Extremadura, 10003, Caceres, Spain.
Lopez JJ; Department of Physiology (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers (IMPB), Universidad de Extremadura, 10003, Caceres, Spain.
Salido GM; Department of Physiology (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers (IMPB), Universidad de Extremadura, 10003, Caceres, Spain.
Smani T; Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.; Departamento de Fisiologia Medica y Biofisica, Facultad de Medicina, Universidad de Sevilla, Seville, Spain.
Rosado JA; Department of Physiology (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers (IMPB), Universidad de Extremadura, 10003, Caceres, Spain. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 Nov 09; Vol. 13 (1), pp. 19471. Date of Electronic Publication: 2023 Nov 09.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Calcium*/metabolism
Triple Negative Breast Neoplasms*
Animals ; Humans ; Calcium Channels/metabolism ; Calcium Signaling/physiology ; Calcium, Dietary/metabolism ; Neoplastic Stem Cells/metabolism ; ORAI1 Protein/genetics ; ORAI1 Protein/metabolism ; Stromal Interaction Molecule 1/metabolism ; Mammals/metabolism

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Skocz do pozycji: 2.

Tytuł:: Neutrophil-specific ORAI1 Calcium Channel Inhibition Reduces Pancreatitis-associated Acute Lung Injury.
Autorzy:: Niu M; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.; Department of Gastroenterology and Shanghai Key Laboratory of Pancreatic Disease, Institute of Pancreatic Disease, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201600, China.
Zhang X; Center for Biomarker Discovery and Validation, National Infrastructures for Translational Medicine (PUMCH), Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100730, China.; Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100730, China.
Wu Z; Department of Gastroenterology and Shanghai Key Laboratory of Pancreatic Disease, Institute of Pancreatic Disease, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201600, China.
Li B; Department of Gastroenterology and Shanghai Key Laboratory of Pancreatic Disease, Institute of Pancreatic Disease, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201600, China.
Bao J; Department of Gastroenterology and Shanghai Key Laboratory of Pancreatic Disease, Institute of Pancreatic Disease, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201600, China.
Dai J; Department of Gastroenterology and Shanghai Key Laboratory of Pancreatic Disease, Institute of Pancreatic Disease, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201600, China.
Yang Z; Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100730, China.
Zeng Y; Department of Gastroenterology and Shanghai Key Laboratory of Pancreatic Disease, Institute of Pancreatic Disease, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201600, China.
Li L; Department of Gastroenterology and Shanghai Key Laboratory of Pancreatic Disease, Institute of Pancreatic Disease, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201600, China.
Pandol S; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Sutton R; Liverpool Pancreatitis Research Group, Liverpool University Hospitals NHS Foundation Trust and Institute of Translational Medicine, University of Liverpool, Liverpool L69 3BX, UK.
Wen L; Center for Biomarker Discovery and Validation, National Infrastructures for Translational Medicine (PUMCH), Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100730, China.; State Key Laboratory of Complex, Severe, and Rare Diseases, Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100730, China.; Pokaż więcej
Źródło:: Function (Oxford, England) [Function (Oxf)] 2023 Oct 23; Vol. 5 (1), pp. zqad061. Date of Electronic Publication: 2023 Oct 23 (Print Publication: 2024).
Typ publikacji:: Journal Article
MeSH Terms:: Acute Lung Injury*/drug therapy
Pancreatitis*/complications
Animals ; Humans ; Mice ; Acute Disease ; Neutrophils/metabolism ; ORAI1 Protein/genetics

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Skocz do pozycji: 3.

Tytuł:: TSPAN18 facilitates bone metastasis of prostate cancer by protecting STIM1 from TRIM32-mediated ubiquitination.
Autorzy:: Zhou Q; Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107th yanjiangxi road, Guangzhou, 510120, China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.; Department of urology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.
Chen X; Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107th yanjiangxi road, Guangzhou, 510120, China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
Yao K; Department of urology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.
Zhang Y; Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107th yanjiangxi road, Guangzhou, 510120, China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
He H; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.; Department of Radiation Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China.
Huang H; Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107th yanjiangxi road, Guangzhou, 510120, China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
Chen H; Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107th yanjiangxi road, Guangzhou, 510120, China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
Peng S; Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107th yanjiangxi road, Guangzhou, 510120, China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
Huang M; Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107th yanjiangxi road, Guangzhou, 510120, China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
Cheng L; Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107th yanjiangxi road, Guangzhou, 510120, China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
Zhang Q; Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107th yanjiangxi road, Guangzhou, 510120, China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
Xie R; Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107th yanjiangxi road, Guangzhou, 510120, China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
Li K; Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107th yanjiangxi road, Guangzhou, 510120, China. .; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China. .
Lin T; Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107th yanjiangxi road, Guangzhou, 510120, China. .; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China. .; Guangdong Provincial Clinical Research Center for Urological Diseases, Guangzhou, 510120, Guangdong, China. .
Huang H; Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107th yanjiangxi road, Guangzhou, 510120, China. .; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China. .; Department of Urology, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, 511518, Guangdong, China. .; Pokaż więcej
Źródło:: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2023 Aug 05; Vol. 42 (1), pp. 195. Date of Electronic Publication: 2023 Aug 05.
Typ publikacji:: Journal Article
MeSH Terms:: Calcium*/metabolism
Prostatic Neoplasms*/genetics
Male ; Humans ; Stromal Interaction Molecule 1/genetics ; Stromal Interaction Molecule 1/chemistry ; Stromal Interaction Molecule 1/metabolism ; Calcium Channels/metabolism ; Ubiquitination ; Calcium Signaling ; ORAI1 Protein/metabolism ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Tripartite Motif Proteins/metabolism ; Transcription Factors/metabolism ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Tetraspanins/genetics ; Tetraspanins/metabolism

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Skocz do pozycji: 4.

Tytuł:: The calcium channel Orai1 is required for osteoblast development: Studies in a chimeric mouse with variable in vivo Runx-cre deletion of Orai-1.
Autorzy:: Robinson LJ; Departments of Pathology, Anatomy and Laboratory Medicine, and of Microbiology, Immunology & Cell Biology, West Virginia University School of Medicine, Morgantown, WV, United States of America.
Soboloff J; Fels Cancer Institute for Personalized Medicine, Department of Cancer and Cellular Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States of America.
Tourkova IL; Departments of Pathology and of Cell Biology, The Pittsburgh VA Medical Center and the University of Pittsburgh, Pittsburgh, PA, United States of America.
Larrouture QC; Departments of Pathology and of Cell Biology, The Pittsburgh VA Medical Center and the University of Pittsburgh, Pittsburgh, PA, United States of America.
Onwuka KM; Departments of Pathology and of Cell Biology, The Pittsburgh VA Medical Center and the University of Pittsburgh, Pittsburgh, PA, United States of America.
Papachristou DJ; Departments of Pathology and of Cell Biology, The Pittsburgh VA Medical Center and the University of Pittsburgh, Pittsburgh, PA, United States of America.; Laboratory of Bone and Soft Tissue Studies, Department of Anatomy-Histology-Embryology, University Patras Medical School, Patras, Greece.
Gross S; Fels Cancer Institute for Personalized Medicine, Department of Cancer and Cellular Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States of America.
Hooper R; Fels Cancer Institute for Personalized Medicine, Department of Cancer and Cellular Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States of America.
Samakai E; Fels Cancer Institute for Personalized Medicine, Department of Cancer and Cellular Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States of America.
Worley PF; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.
Liu P; Institute of Comparative Molecular Endocrinology, Helmholtzstraße, Ulm, Germany.
Tuckermann J; Institute of Comparative Molecular Endocrinology, Helmholtzstraße, Ulm, Germany.
Witt MR; Departments of Pathology, Anatomy and Laboratory Medicine, and of Microbiology, Immunology & Cell Biology, West Virginia University School of Medicine, Morgantown, WV, United States of America.
Blair HC; Departments of Pathology and of Cell Biology, The Pittsburgh VA Medical Center and the University of Pittsburgh, Pittsburgh, PA, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2023 May 11; Vol. 18 (5), pp. e0264596. Date of Electronic Publication: 2023 May 11 (Print Publication: 2023).
Typ publikacji:: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
MeSH Terms:: Calcium Channels*/genetics
Calcium Channels*/metabolism
Core Binding Factor Alpha 1 Subunit*/genetics
Core Binding Factor Alpha 1 Subunit*/metabolism
Osteoblasts*/metabolism
Animals ; Mice ; Calcium/metabolism ; Mice, Knockout ; ORAI1 Protein/genetics ; ORAI1 Protein/metabolism

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Skocz do pozycji: 5.

Tytuł:: Icaritin inhibits oxidative stress in murine astrocytes by binding to Orai1 to block store-operated calcium channel.
Autorzy:: Fan J; Lunan Pharmaceutical Group Co. Ltd., Linyi, China.; State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Linyi, China.
Miao Y; Lunan Pharmaceutical Group Co. Ltd., Linyi, China.
Zhao Y; Lunan Pharmaceutical Group Co. Ltd., Linyi, China.; State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Linyi, China.
Guan Y; Lunan Pharmaceutical Group Co. Ltd., Linyi, China.; State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Linyi, China.
Zhang L; Lunan Pharmaceutical Group Co. Ltd., Linyi, China.; State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Linyi, China.
Pan L; Lunan Pharmaceutical Group Co. Ltd., Linyi, China.; State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Linyi, China.
Feng Q; Lunan Pharmaceutical Group Co. Ltd., Linyi, China.; State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Linyi, China.
Yao J; Lunan Pharmaceutical Group Co. Ltd., Linyi, China.; State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Linyi, China.
Sun C; Lunan Pharmaceutical Group Co. Ltd., Linyi, China.; State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Linyi, China.; Pokaż więcej
Źródło:: Chemical biology & drug design [Chem Biol Drug Des] 2023 Apr; Vol. 101 (4), pp. 873-882. Date of Electronic Publication: 2022 Dec 22.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Calcium Channels*/metabolism
Astrocytes*/metabolism
Mice ; Animals ; Oxidative Stress ; Flavonoids/pharmacology ; Calcium/metabolism ; ORAI1 Protein/metabolism ; ORAI1 Protein/pharmacology

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Skocz do pozycji: 6.

Tytuł:: Searching for Mechanisms Underlying the Assembly of Calcium Entry Units: The Role of Temperature and pH.
Autorzy:: Girolami B; DMSI, Department of Medicine and Aging Sciences & CAST, Center for Advanced Studies and Technology, University G. d'Annunzio of Chieti-Pescara, 66100 Chieti, Italy.
Serano M; DMSI, Department of Medicine and Aging Sciences & CAST, Center for Advanced Studies and Technology, University G. d'Annunzio of Chieti-Pescara, 66100 Chieti, Italy.
Di Fonso A; DMSI, Department of Medicine and Aging Sciences & CAST, Center for Advanced Studies and Technology, University G. d'Annunzio of Chieti-Pescara, 66100 Chieti, Italy.
Paolini C; DNISC, Department of Neuroscience and Clinical Sciences & CAST, Center for Advanced Studies and Technology, University G. d'Annunzio of Chieti-Pescara, 66100 Chieti, Italy.
Pietrangelo L; DMSI, Department of Medicine and Aging Sciences & CAST, Center for Advanced Studies and Technology, University G. d'Annunzio of Chieti-Pescara, 66100 Chieti, Italy.
Protasi F; DMSI, Department of Medicine and Aging Sciences & CAST, Center for Advanced Studies and Technology, University G. d'Annunzio of Chieti-Pescara, 66100 Chieti, Italy.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Mar 10; Vol. 24 (6). Date of Electronic Publication: 2023 Mar 10.
Typ publikacji:: Journal Article
MeSH Terms:: Calcium*/metabolism
Muscle, Skeletal*/metabolism
Mice ; Animals ; Temperature ; Muscle Fibers, Skeletal/metabolism ; Sarcoplasmic Reticulum/metabolism ; Calcium, Dietary ; Hydrogen-Ion Concentration ; ORAI1 Protein ; Stromal Interaction Molecule 1

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Skocz do pozycji: 7.

Tytuł:: The Molecular Heterogeneity of Store-Operated Ca -Selective to Non-Selective Cation Currents.
Autorzy:: Moccia F; Laboratory of General Physiology, Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, 27100 Pavia, Italy.
Brunetti V; Laboratory of General Physiology, Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, 27100 Pavia, Italy.
Perna A; Department of Medicine and Health Sciences, University of Molise, 86100 Campobasso, Italy.
Guerra G; Department of Medicine and Health Sciences, University of Molise, 86100 Campobasso, Italy.
Soda T; Department of Health Sciences, University of Magna Graecia, 88100 Catanzaro, Italy.
Berra-Romani R; Department of Biomedicine, School of Medicine, Benemérita Universidad Autónoma de Puebla, Puebla 72410, Mexico.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Feb 07; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 07.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Calcium Channels*/metabolism
Endothelial Cells*/metabolism
Animals ; Cattle ; Mice ; Rats ; Humans ; TRPC Cation Channels/metabolism ; Stromal Interaction Molecule 1/metabolism ; Calcium/metabolism ; ORAI1 Protein/metabolism ; Calcium Signaling/physiology

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Skocz do pozycji: 8.

Tytuł:: Chlamydia trachomatis suppresses host cell store-operated Ca entry and inhibits NFAT/calcineurin signaling.
Autorzy:: Chamberlain NB; Host-Parasite Interactions Section, Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Dimond Z; Host-Parasite Interactions Section, Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Hackstadt T; Host-Parasite Interactions Section, Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2022 Dec 10; Vol. 12 (1), pp. 21406. Date of Electronic Publication: 2022 Dec 10.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Chlamydia trachomatis*/metabolism
Calcium Signaling*/physiology
Humans ; HeLa Cells ; Stromal Interaction Molecule 1/metabolism ; Calcium/metabolism ; Endoplasmic Reticulum/metabolism ; ORAI1 Protein/metabolism

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Skocz do pozycji: 9.

Tytuł:: Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels.
Autorzy:: Chen X; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China.
Li J; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China.
Zhang R; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China.
Zhang Y; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China.
Wang X; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China.
Leung EL; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China.
Ma L; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China.
Wong VKW; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China.
Liu L; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China.
Neher E; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China.; Emeritus Laboratory of Membrane Biophysics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Yu H; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China.; Pokaż więcej
Źródło:: Journal of extracellular vesicles [J Extracell Vesicles] 2022 Dec; Vol. 11 (12), pp. e12279.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Carcinoma, Non-Small-Cell Lung*
Lung Neoplasms*
Extracellular Vesicles*
Animals ; Mice ; Humans ; B7-H1 Antigen ; Calcium Channels ; ORAI1 Protein

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Skocz do pozycji: 10.

Tytuł:: Similarities and Differences between the Orai1 Variants: Orai1α and Orai1β.
Autorzy:: Jardin I; Department of Physiology (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers (IMPB), University of Extremadura, 10003 Caceres, Spain.
Berna-Erro A; Department of Physiology (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers (IMPB), University of Extremadura, 10003 Caceres, Spain.
Nieto-Felipe J; Department of Physiology (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers (IMPB), University of Extremadura, 10003 Caceres, Spain.
Macias A; Department of Physiology (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers (IMPB), University of Extremadura, 10003 Caceres, Spain.
Sanchez-Collado J; Department of Physiology (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers (IMPB), University of Extremadura, 10003 Caceres, Spain.
Lopez JJ; Department of Physiology (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers (IMPB), University of Extremadura, 10003 Caceres, Spain.
Salido GM; Department of Physiology (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers (IMPB), University of Extremadura, 10003 Caceres, Spain.
Rosado JA; Department of Physiology (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers (IMPB), University of Extremadura, 10003 Caceres, Spain.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Nov 23; Vol. 23 (23). Date of Electronic Publication: 2022 Nov 23.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Calcium*/metabolism
Calcium Channels*/genetics
Calcium Channels*/metabolism
Animals ; ORAI1 Protein/genetics ; ORAI1 Protein/metabolism ; TRPC Cation Channels/metabolism ; Stromal Interaction Molecule 1/genetics ; Stromal Interaction Molecule 1/metabolism ; Ion Transport ; Calcium Signaling

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Skocz do pozycji: 11.

Tytuł:: Functional Role of STIM-1 and Orai1 in Human Microvascular Aging.
Autorzy:: El Assar M; Fundación para la Investigación Biomédica, Hospital Universitario de Getafe, 28905 Getafe, Spain.; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, 28029 Madrid, Spain.
García-Rojo E; Servicio de Urología, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), 28041 Madrid, Spain.
Sevilleja-Ortiz A; Fundación para la Investigación Biomédica, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.
Sánchez-Ferrer A; Fundación para la Investigación Biomédica, Hospital Universitario de Getafe, 28905 Getafe, Spain.
Fernández A; Servicio de Histología-Investigación, Unidad de Investigación Traslacional en Cardiología (IRYCIS-UFV), Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.
García-Gómez B; Servicio de Urología, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), 28041 Madrid, Spain.
Romero-Otero J; Servicio de Urología, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), 28041 Madrid, Spain.
Rodríguez-Mañas L; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Servicio de Geriatría, Hospital Universitario de Getafe, 28905 Getafe, Spain.
Angulo J; Servicio de Histología-Investigación, Unidad de Investigación Traslacional en Cardiología (IRYCIS-UFV), Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.; Pokaż więcej
Źródło:: Cells [Cells] 2022 Nov 18; Vol. 11 (22). Date of Electronic Publication: 2022 Nov 18.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Calcium Channels*/metabolism
Calcium Signaling*/physiology
Aged ; Humans ; Aging ; Calcium/metabolism ; ORAI1 Protein/metabolism ; Middle Aged

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Skocz do pozycji: 12.

Tytuł:: Internalized Amyloid-β (1-42) Peptide Inhibits the Store-Operated Calcium Entry in HT-22 Cells.
Autorzy:: Poejo J; Instituto de Biomarcadores de Patologías Moleculares (IBPM), Universidad de Extremadura, 06006 Badajoz, Spain.; Departamento de Bioquímica y Biología Molecular y Genética, Facultad de Ciencias, Universidad de Extremadura, 06006 Badajoz, Spain.
Orantos-Aguilera Y; Instituto de Biomarcadores de Patologías Moleculares (IBPM), Universidad de Extremadura, 06006 Badajoz, Spain.; Departamento de Bioquímica y Biología Molecular y Genética, Facultad de Ciencias, Universidad de Extremadura, 06006 Badajoz, Spain.
Martin-Romero FJ; Instituto de Biomarcadores de Patologías Moleculares (IBPM), Universidad de Extremadura, 06006 Badajoz, Spain.; Departamento de Bioquímica y Biología Molecular y Genética, Facultad de Ciencias, Universidad de Extremadura, 06006 Badajoz, Spain.
Mata AM; Instituto de Biomarcadores de Patologías Moleculares (IBPM), Universidad de Extremadura, 06006 Badajoz, Spain.; Departamento de Bioquímica y Biología Molecular y Genética, Facultad de Ciencias, Universidad de Extremadura, 06006 Badajoz, Spain.
Gutierrez-Merino C; Instituto de Biomarcadores de Patologías Moleculares (IBPM), Universidad de Extremadura, 06006 Badajoz, Spain.; Departamento de Bioquímica y Biología Molecular y Genética, Facultad de Ciencias, Universidad de Extremadura, 06006 Badajoz, Spain.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Oct 21; Vol. 23 (20). Date of Electronic Publication: 2022 Oct 21.
Typ publikacji:: Journal Article
MeSH Terms:: Calcium*/metabolism
Calmodulin*/metabolism
Mice ; Animals ; Calcium Channels/metabolism ; Green Fluorescent Proteins/metabolism ; Membrane Proteins/metabolism ; Stromal Interaction Molecule 1/metabolism ; Calcium Signaling ; ORAI1 Protein/metabolism

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Skocz do pozycji: 13.

Tytuł:: Reduction in SOCE and Associated Aggregation in Platelets from Mice with Platelet-Specific Deletion of Orai1.
Autorzy:: Yang L; Pharmakologisches Institut, Ruprecht-Karls-Universität Heidelberg, INF 366, 69120 Heidelberg, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120 Heidelberg, Germany.
Ottenheijm R; Pharmakologisches Institut, Ruprecht-Karls-Universität Heidelberg, INF 366, 69120 Heidelberg, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120 Heidelberg, Germany.
Worley P; The Solomon H. Snyder Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Freichel M; Pharmakologisches Institut, Ruprecht-Karls-Universität Heidelberg, INF 366, 69120 Heidelberg, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120 Heidelberg, Germany.
Camacho Londoño JE; Pharmakologisches Institut, Ruprecht-Karls-Universität Heidelberg, INF 366, 69120 Heidelberg, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120 Heidelberg, Germany.; Pokaż więcej
Źródło:: Cells [Cells] 2022 Oct 14; Vol. 11 (20). Date of Electronic Publication: 2022 Oct 14.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Blood Platelets*/metabolism
Calcium*/metabolism
ORAI1 Protein*/metabolism
Animals ; Female ; Male ; Mice ; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid/pharmacology ; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid/metabolism ; Adenosine Diphosphate/metabolism ; Adenosine Triphosphatases/metabolism ; Calcium Channels/metabolism ; Calcium Signaling ; Collagen/metabolism ; Peptides/metabolism ; Stromal Interaction Molecule 1/metabolism ; Thapsigargin/pharmacology ; Thrombin/pharmacology ; Thromboxane A2/metabolism

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Skocz do pozycji: 14.

Tytuł:: Lithium Treatment Improves Cardiac Dysfunction in Rats Deprived of Rapid Eye Movement Sleep.
Autorzy:: Chen PH; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.; Department of Psychiatry, Taipei Medical University Hospital, Taipei 11031, Taiwan.; Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Chung CC; Division of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan.; Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.; Taipei Heart Institute, Taipei Medical University, Taipei 11031, Taiwan.
Liu SH; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.; Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.
Kao YH; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.; Department of Medical Education and Research, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan.
Chen YJ; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.; Division of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan.; Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.; Taipei Heart Institute, Taipei Medical University, Taipei 11031, Taiwan.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Sep 23; Vol. 23 (19). Date of Electronic Publication: 2022 Sep 23.
Typ publikacji:: Journal Article
MeSH Terms:: Heart Diseases*
Sleep, REM*
Actins/metabolism ; Angiotensin II/metabolism ; Animals ; Lithium/pharmacology ; Lithium/therapeutic use ; Lithium Compounds ; NF-kappa B/metabolism ; ORAI1 Protein ; Rats ; Receptor, Angiotensin, Type 1/metabolism ; Sleep Deprivation/complications ; Sleep Deprivation/drug therapy ; Sleep Deprivation/metabolism ; Transforming Growth Factor beta/metabolism

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Skocz do pozycji: 15.

Tytuł:: How filopodia respond to calcium in the absence of a calcium-binding structural protein: non-channel functions of TRP.
Autorzy:: Heckman CA; Department of Biological Sciences, 217 Life Science Building, Bowling Green State University, Bowling Green, OH, 43403-0001, USA. .
Ademuyiwa OM; Department of Biological Sciences, 217 Life Science Building, Bowling Green State University, Bowling Green, OH, 43403-0001, USA.
Cayer ML; Center for Microscopy and Microanalysis, Bowling Green State University, Bowling Green, OH, 43403, USA.; Pokaż więcej
Źródło:: Cell communication and signaling : CCS [Cell Commun Signal] 2022 Aug 26; Vol. 20 (1), pp. 130. Date of Electronic Publication: 2022 Aug 26.
Typ publikacji:: Journal Article; Video-Audio Media; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Calcium*
TRPC Cation Channels*
Calcium Signaling ; Calcium-Binding Proteins ; ORAI1 Protein ; Pseudopodia ; Vesicle-Associated Membrane Protein 2

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Skocz do pozycji: 16.

Tytuł:: Activation of STIM1/Orai1‑mediated SOCE in sepsis‑induced myocardial depression.
Autorzy:: Ye J; Emergency Department, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.
Li M; Emergency Department, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.
Li Q; Ultrasound Department, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.
Jia Z; Ultrasound Department, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.
Hu X; Emergency Department, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.
Zhao G; Emergency Department, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.
Zhi S; Emergency Department, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.
Hong G; Emergency Department, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.
Lu Z; Emergency Department, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2022 Aug; Vol. 26 (2). Date of Electronic Publication: 2022 Jun 17.
Typ publikacji:: Journal Article
MeSH Terms:: Calcium Signaling*
Heart*/physiopathology
ORAI1 Protein*/genetics
ORAI1 Protein*/metabolism
Sepsis*/complications
Stromal Interaction Molecule 1*/genetics
Stromal Interaction Molecule 1*/metabolism
Animals ; Calcium/metabolism ; Mice ; bcl-2-Associated X Protein/metabolism

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Skocz do pozycji: 17.

Tytuł:: PKC-Mediated Orai1 Channel Phosphorylation Modulates Ca Signaling in HeLa Cells.
Autorzy:: Martínez-Martínez E; Department of Biochemistry, Cinvestav, Mexico City 07360, Mexico.
Sánchez-Vázquez VH; Department of Biochemistry, Cinvestav, Mexico City 07360, Mexico.
León-Aparicio D; Department of Biochemistry, Cinvestav, Mexico City 07360, Mexico.; Instituto de Física, Universidad Autónoma de San Luis Potosí, San Luis Potosí 78290, Mexico.
Sanchez-Collado J; Cellular Physiology Research Group, Department of Physiology, Institute of Molecular Pathology Biomarkers, University of Extremadura, 10003 Caceres, Spain.
Gallegos-Gómez ML; Department of Biochemistry, Cinvestav, Mexico City 07360, Mexico.
Rosado JA; Cellular Physiology Research Group, Department of Physiology, Institute of Molecular Pathology Biomarkers, University of Extremadura, 10003 Caceres, Spain.
Arias JM; Programa de Neurociencias-UIICSE, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Tlalnepantla de Baz 54090, Mexico.
Guerrero-Hernández A; Department of Biochemistry, Cinvestav, Mexico City 07360, Mexico.; Pokaż więcej
Źródło:: Cells [Cells] 2022 Jun 27; Vol. 11 (13). Date of Electronic Publication: 2022 Jun 27.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Calcium*/metabolism
Calcium Channels*/metabolism
Adenosine Triphosphate/metabolism ; Adenosine Triphosphate/pharmacology ; HeLa Cells ; Humans ; ORAI1 Protein/metabolism ; Phosphorylation ; Protein Kinase C/metabolism ; Thapsigargin/pharmacology

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Skocz do pozycji: 18.

Tytuł:: Silencing of the Ca Channel ORAI1 Improves the Multi-Systemic Phenotype of Tubular Aggregate Myopathy (TAM) and Stormorken Syndrome (STRMK) in Mice.
Autorzy:: Silva-Rojas R; IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire), Inserm U1258, CNRS UMR7104, Université de Strasbourg, 67404 Illkirch, France.
Pérez-Guàrdia L; IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire), Inserm U1258, CNRS UMR7104, Université de Strasbourg, 67404 Illkirch, France.
Lafabrie E; IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire), Inserm U1258, CNRS UMR7104, Université de Strasbourg, 67404 Illkirch, France.
Moulaert D; Institut Clinique de la Souris (ICS), 67404 Illkirch, France.
Laporte J; IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire), Inserm U1258, CNRS UMR7104, Université de Strasbourg, 67404 Illkirch, France.
Böhm J; IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire), Inserm U1258, CNRS UMR7104, Université de Strasbourg, 67404 Illkirch, France.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Jun 23; Vol. 23 (13). Date of Electronic Publication: 2022 Jun 23.
Typ publikacji:: Journal Article
MeSH Terms:: Blood Platelet Disorders*/genetics
Blood Platelet Disorders*/metabolism
Dyslexia*/genetics
Dyslexia*/metabolism
Ichthyosis*/genetics
Ichthyosis*/metabolism
Myopathies, Structural, Congenital*/genetics
Myopathies, Structural, Congenital*/metabolism
Myopathies, Structural, Congenital*/pathology
ORAI1 Protein*/genetics
ORAI1 Protein*/metabolism
Animals ; Calcium/metabolism ; Erythrocytes, Abnormal ; Mice ; Migraine Disorders/genetics ; Migraine Disorders/metabolism ; Miosis ; Muscle Fatigue ; Phenotype ; Spleen/abnormalities ; Spleen/metabolism ; Stromal Interaction Molecule 1/genetics ; Stromal Interaction Molecule 1/metabolism
SCR Disease Name:: Stormorken Syndrome

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Skocz do pozycji: 19.

Tytuł:: Science CommuniCa tion Developing Scientific Literacy on Calcium: The Involvement of CRAC Currents in Human Health and Disease.
Autorzy:: Humer C; Life Science Center, Johannes Kepler University Linz, Gruberstrasse 40, 4020 Linz, Austria.
Berlansky S; Life Science Center, Johannes Kepler University Linz, Gruberstrasse 40, 4020 Linz, Austria.
Grabmayr H; Life Science Center, Johannes Kepler University Linz, Gruberstrasse 40, 4020 Linz, Austria.
Sallinger M; Life Science Center, Johannes Kepler University Linz, Gruberstrasse 40, 4020 Linz, Austria.
Bernhard A; Life Science Center, Johannes Kepler University Linz, Gruberstrasse 40, 4020 Linz, Austria.
Fahrner M; Life Science Center, Johannes Kepler University Linz, Gruberstrasse 40, 4020 Linz, Austria.
Frischauf I; Life Science Center, Johannes Kepler University Linz, Gruberstrasse 40, 4020 Linz, Austria.; Pokaż więcej
Źródło:: Cells [Cells] 2022 Jun 05; Vol. 11 (11). Date of Electronic Publication: 2022 Jun 05.
Typ publikacji:: Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:: Calcium*/metabolism
Calcium Release Activated Calcium Channels*/metabolism
Calcium Signaling/physiology ; Humans ; Literacy ; ORAI1 Protein/metabolism

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Skocz do pozycji: 20.

Tytuł:: ORAI1-Regulated Gene Expression in Breast Cancer Cells: Roles for STIM1 Binding, Calcium Influx and Transcription Factor Translocation.
Autorzy:: Robitaille M; School of Pharmacy, The University of Queensland, Brisbane, QLD 4102, Australia.
Chan SM; School of Pharmacy, The University of Queensland, Brisbane, QLD 4102, Australia.
Peters AA; School of Pharmacy, The University of Queensland, Brisbane, QLD 4102, Australia.
Dai L; School of Pharmacy, The University of Queensland, Brisbane, QLD 4102, Australia.
So CL; School of Pharmacy, The University of Queensland, Brisbane, QLD 4102, Australia.
Bong AHL; School of Pharmacy, The University of Queensland, Brisbane, QLD 4102, Australia.
Sadras F; School of Pharmacy, The University of Queensland, Brisbane, QLD 4102, Australia.
Roberts-Thomson SJ; School of Pharmacy, The University of Queensland, Brisbane, QLD 4102, Australia.
Monteith GR; School of Pharmacy, The University of Queensland, Brisbane, QLD 4102, Australia.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 May 24; Vol. 23 (11). Date of Electronic Publication: 2022 May 24.
Typ publikacji:: Journal Article
MeSH Terms:: Breast Neoplasms*/genetics
Calcium*/metabolism
Calcium Channels/metabolism ; Calcium Signaling/physiology ; Calcium, Dietary ; Female ; Gene Expression ; Gene Expression Regulation ; Humans ; Neoplasm Proteins/metabolism ; ORAI1 Protein/genetics ; ORAI1 Protein/metabolism ; Stromal Interaction Molecule 1/genetics ; Stromal Interaction Molecule 1/metabolism ; Transcription Factors/metabolism

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