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Tytuł :
[Establishment of mini-guts organoid and research on intestinal disease from the new perspective].
Autorzy :
Xu ZY; Research Institute of General Surgery, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China.
Liu Y; Research Institute of General Surgery, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China.
Jiang YG; Research Institute of General Surgery, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China.
Huang JJ; Research Institute of General Surgery, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China.
Wu XW; Research Institute of General Surgery, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China.
Ren JA; Research Institute of General Surgery, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China.
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Źródło :
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery [Zhonghua Wei Chang Wai Ke Za Zhi] 2021 Jul 25; Vol. 24 (7), pp. 638-643.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Intestinal Neoplasms*
Organoids*
Humans ; Intestinal Mucosa ; Intestines ; Stem Cells ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
A deep learning model for detection and tracking in high-throughput images of organoid.
Autorzy :
Bian X; Fujian Key Laboratory of Sensing and Computing for Smart City, School of Informatics, Xiamen University, Xiamen, 361005, China. Electronic address: .
Li G; Nanfang Hospital, Southern Medical University, Guangzhou, 510000, China. Electronic address: .
Wang C; Fujian Key Laboratory of Sensing and Computing for Smart City, School of Informatics, Xiamen University, Xiamen, 361005, China. Electronic address: .
Liu W; Fujian Key Laboratory of Sensing and Computing for Smart City, School of Informatics, Xiamen University, Xiamen, 361005, China. Electronic address: .
Lin X; Fujian Key Laboratory of Sensing and Computing for Smart City, School of Informatics, Xiamen University, Xiamen, 361005, China. Electronic address: .
Chen Z; Accurate International Biotechnology (GZ) Co., Ltd, Guangzhou, 510000, China. Electronic address: .
Cheung M; Accurate International Biotechnology (GZ) Co., Ltd, Guangzhou, 510000, China. Electronic address: .
Luo X; Fujian Key Laboratory of Sensing and Computing for Smart City, School of Informatics, Xiamen University, Xiamen, 361005, China. Electronic address: .
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Źródło :
Computers in biology and medicine [Comput Biol Med] 2021 Jul; Vol. 134, pp. 104490. Date of Electronic Publication: 2021 May 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Deep Learning*
Organoids*
Neural Networks, Computer ; Precision Medicine
Czasopismo naukowe
Tytuł :
Experimental Models for SARS-CoV-2 Infection.
Autorzy :
Kim T; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea.; These authors contributed equally to this work.
Lee JS; GENOME INSIGHT Inc., Daejeon 34051, Korea.; These authors contributed equally to this work.
Ju YS; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea.; GENOME INSIGHT Inc., Daejeon 34051, Korea.
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Źródło :
Molecules and cells [Mol Cells] 2021 Jun 30; Vol. 44 (6), pp. 377-383.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Models, Theoretical*
COVID-19/*virology
Organoids/*virology
SARS-CoV-2/*pathogenicity
Animals ; COVID-19/immunology ; COVID-19/pathology ; Cats ; Cell Line, Tumor ; Chickens/virology ; Chlorocebus aethiops/virology ; Cricetinae ; Dogs ; Ferrets/virology ; Humans ; Mice ; Organoids/immunology ; Organoids/pathology ; Rabbits ; SARS-CoV-2/growth & development ; Swine/virology ; Vero Cells
Czasopismo naukowe
Tytuł :
High Glucose Exposure Impairs L-Cell Differentiation in Intestinal Organoids: Molecular Mechanisms and Clinical Implications.
Autorzy :
Filippello A; Department of Clinical and Experimental Medicine, Internal Medicine, Garibaldi-Nesima Hospital, University of Catania, Via Palermo, 636, 95122 Catania, Italy.
Di Mauro S; Department of Clinical and Experimental Medicine, Internal Medicine, Garibaldi-Nesima Hospital, University of Catania, Via Palermo, 636, 95122 Catania, Italy.
Scamporrino A; Department of Clinical and Experimental Medicine, Internal Medicine, Garibaldi-Nesima Hospital, University of Catania, Via Palermo, 636, 95122 Catania, Italy.
Malaguarnera R; Faculty of Medicine and Surgery, 'Kore' University of Enna, 94100 Enna, Italy.
Torrisi SA; Department of Biomedical and Biotechnological Sciences, University of Catania, Via S. Sofia, 64, 95123 Catania, Italy.
Leggio GM; Department of Biomedical and Biotechnological Sciences, University of Catania, Via S. Sofia, 64, 95123 Catania, Italy.
Di Pino A; Department of Clinical and Experimental Medicine, Internal Medicine, Garibaldi-Nesima Hospital, University of Catania, Via Palermo, 636, 95122 Catania, Italy.
Scicali R; Department of Clinical and Experimental Medicine, Internal Medicine, Garibaldi-Nesima Hospital, University of Catania, Via Palermo, 636, 95122 Catania, Italy.
Purrello F; Department of Clinical and Experimental Medicine, Internal Medicine, Garibaldi-Nesima Hospital, University of Catania, Via Palermo, 636, 95122 Catania, Italy.
Piro S; Department of Clinical and Experimental Medicine, Internal Medicine, Garibaldi-Nesima Hospital, University of Catania, Via Palermo, 636, 95122 Catania, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 22; Vol. 22 (13). Date of Electronic Publication: 2021 Jun 22.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Differentiation*
Organoids*
Enteroendocrine Cells/*metabolism
Hyperglycemia/*complications
Intestine, Small/*metabolism
Animals ; Diabetes Mellitus, Type 2/complications ; Enteroendocrine Cells/drug effects ; Enteroendocrine Cells/physiology ; Glucose/metabolism ; Glucose/toxicity ; Intestine, Small/drug effects ; Intestine, Small/physiopathology ; L Cells ; Male ; Mice ; Mice, Inbred C57BL ; Signal Transduction
Czasopismo naukowe
Tytuł :
Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors.
Autorzy :
Zeng Z; USC/UKRO Kidney Research Center, Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Deptartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Huang B; USC/UKRO Kidney Research Center, Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Deptartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Parvez RK; Deptartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Li Y; USC/UKRO Kidney Research Center, Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Deptartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Chen J; USC/UKRO Kidney Research Center, Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Deptartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Vonk AC; USC/UKRO Kidney Research Center, Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Deptartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Thornton ME; Division of Maternal Fetal Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Patel T; USC/UKRO Kidney Research Center, Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Deptartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Rutledge EA; Deptartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Kim AD; Deptartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Yu J; USC/UKRO Kidney Research Center, Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Deptartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Grubbs BH; Division of Maternal Fetal Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
McMahon JA; Deptartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Pastor-Soler NM; USC/UKRO Kidney Research Center, Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Hallows KR; USC/UKRO Kidney Research Center, Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
McMahon AP; Deptartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Li Z; USC/UKRO Kidney Research Center, Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. .; Deptartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jun 15; Vol. 12 (1), pp. 3641. Date of Electronic Publication: 2021 Jun 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Ureter*
Kidney/*cytology
Kidney/*growth & development
Kidney Tubules, Collecting/*cytology
Organogenesis/*physiology
Organoids/*cytology
Organoids/*growth & development
Urinary Tract/*cytology
Adult ; Animals ; Cell Differentiation ; Cells, Cultured ; Humans ; Kidney/embryology ; Kidney Tubules, Collecting/embryology ; Male ; Mice ; Morphogenesis ; Nephrons ; Organogenesis/genetics ; Organoids/embryology ; Pluripotent Stem Cells/cytology ; Urinary Tract/embryology ; Urinary Tract/growth & development
Czasopismo naukowe
Tytuł :
SOX9 inactivation affects the proliferation and differentiation of human lung organoids.
Autorzy :
Li L; State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Key Laboratory of Organ Failure Research (Ministry of Education), Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Feng J; State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Key Laboratory of Organ Failure Research (Ministry of Education), Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Zhao S; State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Key Laboratory of Organ Failure Research (Ministry of Education), Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Rong Z; State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Key Laboratory of Organ Failure Research (Ministry of Education), Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China. .; Dermatology Hospital, Southern Medical University, Guangzhou, 510091, China. .; Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, 510005, China. .
Lin Y; State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Key Laboratory of Organ Failure Research (Ministry of Education), Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China. .
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Źródło :
Stem cell research & therapy [Stem Cell Res Ther] 2021 Jun 10; Vol. 12 (1), pp. 343. Date of Electronic Publication: 2021 Jun 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Differentiation*
Lung*
Organoids*
SOX9 Transcription Factor/*genetics
Animals ; Cell Proliferation ; Epithelial Cells ; Gene Knockdown Techniques ; Humans ; Mice
Czasopismo naukowe
Tytuł :
3D Modeling of Epithelial Tumors-The Synergy between Materials Engineering, 3D Bioprinting, High-Content Imaging, and Nanotechnology.
Autorzy :
Trivedi P; Laboratory of Natural Materials Technology, Faculty of Science and Engineering, Åbo Akademi University, 20500 Turku, Finland.
Liu R; Laboratory of Natural Materials Technology, Faculty of Science and Engineering, Åbo Akademi University, 20500 Turku, Finland.
Bi H; Laboratory of Natural Materials Technology, Faculty of Science and Engineering, Åbo Akademi University, 20500 Turku, Finland.; Key Laboratory of Bio-Based Material Science and Technology (Ministry of Education), Material Science and Engineering College, Northeast Forestry University, Harbin 150040, China.
Xu C; Laboratory of Natural Materials Technology, Faculty of Science and Engineering, Åbo Akademi University, 20500 Turku, Finland.
Rosenholm JM; Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University, 20500 Turku, Finland.
Åkerfelt M; Cell Biology, Faculty of Science and Engineering, Åbo Akademi University, 20500 Turku, Finland.; Institute of Biomedicine, University of Turku, 20520 Turku, Finland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 09; Vol. 22 (12). Date of Electronic Publication: 2021 Jun 09.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Bioprinting*
Breast Neoplasms*/diagnostic imaging
Breast Neoplasms*/metabolism
Breast Neoplasms*/pathology
Models, Biological*
Neoplasms, Glandular and Epithelial*/diagnostic imaging
Neoplasms, Glandular and Epithelial*/metabolism
Neoplasms, Glandular and Epithelial*/pathology
Organoids*/diagnostic imaging
Organoids*/metabolism
Organoids*/pathology
Printing, Three-Dimensional*
Prostatic Neoplasms*/diagnostic imaging
Prostatic Neoplasms*/metabolism
Prostatic Neoplasms*/pathology
Animals ; Female ; Humans ; Male ; Nanotechnology ; Tissue Engineering
Czasopismo naukowe
Tytuł :
Resolving organoid brain region identities by mapping single-cell genomic data to reference atlases.
Autorzy :
Fleck JS; Department of Biosystems Science and Engineering, ETH Zürich, 4058 Basel, Switzerland.
Sanchís-Calleja F; Department of Biosystems Science and Engineering, ETH Zürich, 4058 Basel, Switzerland.
He Z; Department of Biosystems Science and Engineering, ETH Zürich, 4058 Basel, Switzerland.
Santel M; Department of Biosystems Science and Engineering, ETH Zürich, 4058 Basel, Switzerland.
Boyle MJ; Max Planck Institute for Evolutionary Anthropology, Leipzig, 04103 Sachsen, Germany.
Camp JG; Institute of Molecular and Clinical Ophthalmology Basel, 4031 Basel, Switzerland; Department of Ophthalmology, University of Basel, 4031 Basel, Switzerland. Electronic address: .
Treutlein B; Department of Biosystems Science and Engineering, ETH Zürich, 4058 Basel, Switzerland. Electronic address: .
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Źródło :
Cell stem cell [Cell Stem Cell] 2021 Jun 03; Vol. 28 (6), pp. 1148-1159.e8. Date of Electronic Publication: 2021 Mar 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain*
Organoids*
Cell Differentiation/genetics ; Genomics ; Humans ; Transcriptome
Czasopismo naukowe
Tytuł :
Epithelial Regeneration Ability of Crohn's Disease Assessed Using Patient-Derived Intestinal Organoids.
Autorzy :
Lee C; Samsung Medical Center, Department of Medicine, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 0635l, Korea.; Stem Cell & Regenerative Medicine Center, Samsung Medical Center, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea.
Hong SN; Samsung Medical Center, Department of Medicine, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 0635l, Korea.; Stem Cell & Regenerative Medicine Center, Samsung Medical Center, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea.
Kim ER; Samsung Medical Center, Department of Medicine, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 0635l, Korea.
Chang DK; Samsung Medical Center, Department of Medicine, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 0635l, Korea.
Kim YH; Samsung Medical Center, Department of Medicine, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 0635l, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 02; Vol. 22 (11). Date of Electronic Publication: 2021 Jun 02.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Proliferation/*genetics
Crohn Disease/*therapy
Epithelial Cells/*metabolism
Organoids/*growth & development
Adult ; Crohn Disease/metabolism ; Crohn Disease/pathology ; Epithelial Cells/pathology ; Female ; Humans ; Ileum/growth & development ; Ileum/injuries ; Ileum/pathology ; Intestinal Mucosa/growth & development ; Intestinal Mucosa/pathology ; Intestines/diagnostic imaging ; Intestines/injuries ; Male ; Middle Aged ; Organoids/metabolism ; Regeneration/genetics ; Signal Transduction/genetics ; Stem Cells/cytology ; Stem Cells/metabolism ; Tumor Necrosis Factor-alpha/genetics ; Wound Healing/genetics
Czasopismo naukowe
Tytuł :
Spheroids and organoids as humanized 3D scaffold-free engineered tissues for SARS-CoV-2 viral infection and drug screening.
Autorzy :
Kronemberger GS; Nucleus of Multidisciplinary Research in Biology (Numpex-Bio), Federal University of Rio de Janeiro (UFRJ), Campus Duque de Caxias, Rio de Janeiro, Brazil.; Postgraduation Program of Translational Biomedicine (Biotrans), Unigranrio, Campus I, Duque de Caxias, Brazil.
Carneiro FA; Nucleus of Multidisciplinary Research in Biology (Numpex-Bio), Federal University of Rio de Janeiro (UFRJ), Campus Duque de Caxias, Rio de Janeiro, Brazil.
Rezende DF; GCell 3D cell culture, Rio de Janeiro, Brazil.
Baptista LS; Nucleus of Multidisciplinary Research in Biology (Numpex-Bio), Federal University of Rio de Janeiro (UFRJ), Campus Duque de Caxias, Rio de Janeiro, Brazil.; Postgraduation Program of Translational Biomedicine (Biotrans), Unigranrio, Campus I, Duque de Caxias, Brazil.
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Źródło :
Artificial organs [Artif Organs] 2021 Jun; Vol. 45 (6), pp. 548-558. Date of Electronic Publication: 2021 Jan 10.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antiviral Agents/*pharmacology
COVID-19/*drug therapy
Organoids/*physiology
Spheroids, Cellular/*physiology
Tissue Engineering/*methods
Cells, Cultured ; Drug Evaluation, Preclinical ; Humans ; Organoids/virology ; SARS-CoV-2 ; Spheroids, Cellular/virology ; Tissue Scaffolds
Czasopismo naukowe
Tytuł :
[Induction of mouse T lymphocyte differentiation in vitro by thymic organoids].
Autorzy :
Gong M; Center for Clinical Molecular Medicine, Children's Hospital, Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders (Chongqing), China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Engineering Research Center for Stem Cell Therapy, Chongqing 400014, China.
Fu G; Center for Clinical Molecular Medicine, Children's Hospital, Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders (Chongqing), China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Engineering Research Center for Stem Cell Therapy, Chongqing 400014, China.
Shu Y; Center for Clinical Molecular Medicine, Children's Hospital, Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders (Chongqing), China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Engineering Research Center for Stem Cell Therapy, Chongqing 400014, China.
Zhu D; Center for Clinical Molecular Medicine, Children's Hospital, Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders (Chongqing), China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Engineering Research Center for Stem Cell Therapy, Chongqing 400014, China.
Jiang T; Center for Clinical Molecular Medicine, Children's Hospital, Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders (Chongqing), China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Engineering Research Center for Stem Cell Therapy, Chongqing 400014, China.
Wang H; Center for Clinical Molecular Medicine, Children's Hospital, Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders (Chongqing), China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Engineering Research Center for Stem Cell Therapy, Chongqing 400014, China.
Liu Z; Center for Clinical Molecular Medicine, Children's Hospital, Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders (Chongqing), China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Engineering Research Center for Stem Cell Therapy, Chongqing 400014, China.
Su H; Center for Clinical Molecular Medicine, Children's Hospital, Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders (Chongqing), China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Engineering Research Center for Stem Cell Therapy, Chongqing 400014, China.
Zou L; Center for Clinical Molecular Medicine, Children's Hospital, Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders (Chongqing), China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Engineering Research Center for Stem Cell Therapy, Chongqing 400014, China. *Corresponding author, E-mail: .
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Źródło :
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology [Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi] 2021 Aug; Vol. 37 (8), pp. 679-686.
Typ publikacji :
Journal Article
MeSH Terms :
Hematopoietic Stem Cells*
Organoids*
Animals ; Cell Differentiation ; Cells, Cultured ; Mice ; Mice, Inbred C57BL ; T-Lymphocytes ; Thymus Gland
Czasopismo naukowe
Tytuł :
Morphological screening of mesenchymal mammary tumor organoids to identify drugs that reverse epithelial-mesenchymal transition.
Autorzy :
Zhao N; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Powell RT; Center for Translational Cancer Research, Texas A&M Health Science Center, Institute of Biosciences and Technology, Houston, TX, USA.
Yuan X; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Bae G; Center for Translational Cancer Research, Texas A&M Health Science Center, Institute of Biosciences and Technology, Houston, TX, USA.
Roarty KP; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Stossi F; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.; Integrated Microscopy Core, Baylor College of Medicine, Houston, TX, USA.
Strempfl M; Graz University of Technology, NAWI Graz, Graz, Styria, Austria.
Toneff MJ; Department of Biology, Widener University, Chester, PA, USA.
Johnson HL; Integrated Microscopy Core, Baylor College of Medicine, Houston, TX, USA.
Mani SA; Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Jones P; Institute of Applied Cancer Science (IACS), University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Stephan CC; Center for Translational Cancer Research, Texas A&M Health Science Center, Institute of Biosciences and Technology, Houston, TX, USA.
Rosen JM; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jul 12; Vol. 12 (1), pp. 4262. Date of Electronic Publication: 2021 Jul 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antineoplastic Agents/*pharmacology
Epithelial-Mesenchymal Transition/*drug effects
Mammary Neoplasms, Animal/*pathology
Mesoderm/*pathology
Organoids/*pathology
Animals ; Azacitidine/pharmacology ; Benzamides/pharmacology ; Drug Screening Assays, Antitumor ; Epigenesis, Genetic ; Female ; Gene Expression Regulation, Neoplastic ; Image Processing, Computer-Assisted ; Mammary Neoplasms, Animal/genetics ; Mice, Inbred BALB C ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Neoplasm Proteins/metabolism ; Organoids/drug effects ; Pyrimidines/pharmacology ; Reproducibility of Results ; Small Molecule Libraries/pharmacology
Czasopismo naukowe
Tytuł :
[Organoids derived from the digestive system and their perspective applications in exercise physiology].
Autorzy :
Zhang ZY; School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China.
Xiang D; Naval Research Institute, Naval Medical University, Shanghai 200433, China.
Luo BB; School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China. .
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Źródło :
Sheng li xue bao : [Acta physiologica Sinica] [Sheng Li Xue Bao] 2021 Jun 25; Vol. 73 (3), pp. 509-517.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Intestines*
Organoids*
Animals ; Cell Differentiation ; Epithelial Cells ; Hepatocytes ; Humans
Czasopismo naukowe
Tytuł :
Using esophagus organoid to explore the role of c-Myc in esophageal cancer initiation.
Autorzy :
Chen YH; School of Life Sciences Fudan University, Shanghai 200433, China.
Yang WH; School of Life Sciences Fudan University, Shanghai 200433, China.; Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Ni C; School of Life Sciences Fudan University, Shanghai 200433, China.
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Źródło :
Yi chuan = Hereditas [Yi Chuan] 2021 Jun 20; Vol. 43 (6), pp. 601-614.
Typ publikacji :
Journal Article
MeSH Terms :
Esophageal Neoplasms*/genetics
Organoids*
Cell Proliferation ; Humans ; Proto-Oncogene Proteins c-myc/genetics
Czasopismo naukowe
Tytuł :
Axial elongation of caudalized human organoids mimics aspects of neural tube development.
Autorzy :
Libby ARG; Developmental and Stem Cell Biology PhD Program, University of California, San Francisco, CA 94143, USA.; Gladstone Institutes, San Francisco, CA 94158, USA.
Joy DA; Gladstone Institutes, San Francisco, CA 94158, USA.; UC Berkeley-UC San Francisco Graduate Program in Bioengineering, San Francisco, CA 94158, USA.
Elder NH; Developmental and Stem Cell Biology PhD Program, University of California, San Francisco, CA 94143, USA.; Gladstone Institutes, San Francisco, CA 94158, USA.
Bulger EA; Developmental and Stem Cell Biology PhD Program, University of California, San Francisco, CA 94143, USA.; Gladstone Institutes, San Francisco, CA 94158, USA.
Krakora MZ; Gladstone Institutes, San Francisco, CA 94158, USA.
Gaylord EA; Developmental and Stem Cell Biology PhD Program, University of California, San Francisco, CA 94143, USA.
Mendoza-Camacho F; Developmental and Stem Cell Biology PhD Program, University of California, San Francisco, CA 94143, USA.
Butts JC; Gladstone Institutes, San Francisco, CA 94158, USA.
McDevitt TC; Gladstone Institutes, San Francisco, CA 94158, USA.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158, USA.
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Źródło :
Development (Cambridge, England) [Development] 2021 Jun 15; Vol. 148 (12). Date of Electronic Publication: 2021 Jun 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Body Patterning*/drug effects
Organogenesis*/drug effects
Organoids*
Neural Tube/*embryology
Cell Differentiation ; Embryonic Development ; Gene Expression Regulation, Developmental ; Humans ; Mesoderm/embryology ; Mesoderm/metabolism ; Neurogenesis/drug effects ; Pluripotent Stem Cells/cytology ; Pluripotent Stem Cells/metabolism ; Wnt Signaling Pathway/drug effects
Czasopismo naukowe
Tytuł :
Enhanced mechanosensing of cells in synthetic 3D matrix with controlled biophysical dynamics.
Autorzy :
Yang B; Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong, China.
Wei K; Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong, China.; Empa, Swiss Federal Laboratories for Materials Science and Technology, Laboratory for Biomimetic Membranes and Textiles, St. Gallen, Switzerland.
Loebel C; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
Zhang K; Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong, China.; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, USA.
Feng Q; Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong, China.; Key Laboratory of Biorheological Science and Technology, Ministry of Education College of Bioengineering, Chongqing University, Chongqing, China.
Li R; Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong, China.
Wong SHD; Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong, China.; Department of Biomedical Engineering, The Hong Kong Polytechnic University, HongKong, China.
Xu X; Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong, China.
Lau C; Department of Physics, The Chinese University of Hong Kong, Hong Kong, China.
Chen X; Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong, China.; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Zhao P; Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong, China.
Yin C; Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong, China.
Burdick JA; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
Wang Y; Department of Physics, The Chinese University of Hong Kong, Hong Kong, China. .
Bian L; Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong, China. .; Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China. .; China Orthopedic Regenerative Medicine Group (CORMed), Hangzhou, Zhejiang, China. .
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Źródło :
Nature communications [Nat Commun] 2021 Jun 10; Vol. 12 (1), pp. 3514. Date of Electronic Publication: 2021 Jun 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Adhesion*
Cellular Microenvironment*
Osteogenesis*
Biomimetics/*methods
Cell Culture Techniques/*methods
Hydrogels/*chemistry
Mesenchymal Stem Cells/*metabolism
Organoids/*metabolism
Adamantane/chemistry ; Biocompatible Materials/chemistry ; Cholic Acid ; Computer Simulation ; Cross-Linking Reagents/chemistry ; Cyclodextrins/chemistry ; Extracellular Matrix ; Humans ; Kinetics ; Ligands ; Mechanotransduction, Cellular ; Mesenchymal Stem Cells/cytology ; Molecular Dynamics Simulation ; Organoids/cytology ; Thermodynamics
Czasopismo naukowe
Tytuł :
Generation of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo.
Autorzy :
Tanimizu N; Department of Tissue Development and Regeneration, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan. .
Ichinohe N; Department of Tissue Development and Regeneration, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
Sasaki Y; Biology Division, Department of Liberal Arts and Sciences, Center for Medical Education, Sapporo Medical University, Sapporo, Japan.; Department of Medical Genome Sciences, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
Itoh T; Laboratory of Stem Cell Therapy, The Institute for Quantitative Biosciences, The University of Tokyo, Tokyo, Japan.
Sudo R; Department of System Design Engineering, Keio University, Yokohama, Japan.
Yamaguchi T; Department of Molecular and Cellular Medicine, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan.
Katsuda T; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Ninomiya T; Department of Anatomy, Sapporo Medical University School of Medicine, Sapporo, Japan.
Tokino T; Department of Medical Genome Sciences, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
Ochiya T; Department of Molecular and Cellular Medicine, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan.
Miyajima A; Laboratory of Stem Cell Therapy, The Institute for Quantitative Biosciences, The University of Tokyo, Tokyo, Japan.
Mitaka T; Department of Tissue Development and Regeneration, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
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Źródło :
Nature communications [Nat Commun] 2021 Jun 07; Vol. 12 (1), pp. 3390. Date of Electronic Publication: 2021 Jun 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bile Ducts, Intrahepatic/*cytology
Cell Communication/*physiology
Liver/*cytology
Organoids/*physiology
Primary Cell Culture/*methods
Animals ; Bile Ducts, Intrahepatic/physiology ; Cell Differentiation ; Cells, Cultured ; Hepatocytes/physiology ; Liver/physiology ; Mice ; Organoids/cytology ; Stem Cells/physiology
Czasopismo naukowe
Tytuł :
Mapping human brain organoids on a spatial atlas.
Autorzy :
Miura Y; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA; Stanford Brain Organogenesis, Wu Tsai Neuroscience Institute, Stanford University, Stanford, CA 94305, USA.
Pașca SP; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA; Stanford Brain Organogenesis, Wu Tsai Neuroscience Institute, Stanford University, Stanford, CA 94305, USA. Electronic address: .
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Źródło :
Cell stem cell [Cell Stem Cell] 2021 Jun 03; Vol. 28 (6), pp. 983-984.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Organoids*
Pluripotent Stem Cells*
Brain ; Genomics ; Humans
Czasopismo naukowe
Tytuł :
Cholangiocyte organoids as a cell source for biliary repair.
Autorzy :
Velazquez JJ; Department of Pathology, Division of Experimental Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, USA.
Ebrahimkhani MR; Department of Pathology, Division of Experimental Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA.; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
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Źródło :
Transplant international : official journal of the European Society for Organ Transplantation [Transpl Int] 2021 Jun; Vol. 34 (6), pp. 999-1001. Date of Electronic Publication: 2021 Jun 10.
Typ publikacji :
News; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Bile Ducts*
Organoids*
Epithelial Cells
Periodyk
Tytuł :
Intelligent acoustofluidics enabled mini-bioreactors for human brain organoids.
Autorzy :
Cai H; Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN 47405, USA. .
Ao Z; Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN 47405, USA. .
Wu Z; Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN 47405, USA. .
Song S; Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN 47405, USA. .
Mackie K; Gill Center for Biomolecular Science, and, Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA.
Guo F; Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN 47405, USA. .
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Źródło :
Lab on a chip [Lab Chip] 2021 Jun 01; Vol. 21 (11), pp. 2194-2205.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Bioreactors*
Organoids*
Acoustics ; Brain ; Humans ; Microfluidics
Czasopismo naukowe

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