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Wyszukujesz frazę ""OROTIC acid"" wg kryterium: Temat


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Tytuł :
Orotic acid protects pancreatic β cell by p53 inactivation in diabetic mouse model.
Autorzy :
Fushimura Y; Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.
Hoshino A; Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.
Furukawa S; Furukawa Research Office Co. Ltd., Tokyo, 157-0066, Japan.
Nakagawa T; Department of Molecular and Medical Pharmacology Faculty of Medicine, University of Toyama, Toyama, 930-0194, Japan.
Hino T; Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.
Taminishi S; Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.
Minami Y; Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.
Urata R; Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.
Iwai-Kanai E; Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan; Faculty of Health Care, Tenri Health Care University, Nara, 632-0018, Japan.
Matoba S; Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Dec 31; Vol. 585, pp. 191-195. Date of Electronic Publication: 2021 Oct 29.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
Diabetes Mellitus, Type 2/*metabolism
Insulin-Secreting Cells/*drug effects
Orotic Acid/*pharmacology
Tumor Suppressor Protein p53/*metabolism
Animals ; Apoptosis/drug effects ; Blood Glucose/metabolism ; Body Weight/drug effects ; Cell Line, Tumor ; Cytosol/drug effects ; Cytosol/metabolism ; Diabetes Mellitus, Type 2/blood ; Humans ; Insulin Secretion/drug effects ; Insulin-Secreting Cells/metabolism ; Male ; Mice, Inbred C57BL ; Orotic Acid/administration & dosage ; Orotic Acid/blood ; Protective Agents/administration & dosage ; Protective Agents/pharmacology
Czasopismo naukowe
Tytuł :
Synthesis, Structure and Impact of 5-Aminoorotic Acid and Its Complexes with Lanthanum(III) and Gallium(III) on the Activity of Xanthine Oxidase.
Autorzy :
Todorov L; Department of Chemistry, Faculty of Pharmacy, Medical University, 1000 Sofia, Bulgaria.
Saso L; Department of Physiology and Pharmacology 'Vittorio Erspamer', Faculty of Pharmacy and Medicine, Sapienza University, 00185 Rome, Italy.
Benarous K; Laboratoire des Sciences Fondamentales, Université Amar Telidji, Laghouat 03000, Algeria.
Traykova M; Department of Physics and Biophysics, Faculty of Medicine, Medical University, 1431 Sofia, Bulgaria.
Linani A; Laboratoire des Sciences Fondamentales, Université Amar Telidji, Laghouat 03000, Algeria.
Kostova I; Department of Chemistry, Faculty of Pharmacy, Medical University, 1000 Sofia, Bulgaria.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Jul 26; Vol. 26 (15). Date of Electronic Publication: 2021 Jul 26.
Typ publikacji :
Journal Article
MeSH Terms :
Enzyme Inhibitors/*chemistry
Gallium/*chemistry
Lanthanum/*chemistry
Orotic Acid/*analogs & derivatives
Superoxides/*chemistry
Xanthine Oxidase/*antagonists & inhibitors
Orotic Acid/chemistry
Czasopismo naukowe
Tytuł :
Hypoxia Active Platinum(IV) Prodrugs of Orotic Acid Selective to Liver Cancer Cells.
Autorzy :
Maji M; Department of Chemical Sciences and Centre for Advanced Functional Materials, Indian Institute of Science Education and Research (IISER) Kolkata, Mohanpur 741246, West Bengal, India.
Bhattacharya I; Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Kolkata, Mohanpur 741246, West Bengal, India.
Acharya S; Department of Chemical Sciences and Centre for Advanced Functional Materials, Indian Institute of Science Education and Research (IISER) Kolkata, Mohanpur 741246, West Bengal, India.
Chakraborty MP; Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Kolkata, Mohanpur 741246, West Bengal, India.
Gupta A; Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Kolkata, Mohanpur 741246, West Bengal, India.
Mukherjee A; Department of Chemical Sciences and Centre for Advanced Functional Materials, Indian Institute of Science Education and Research (IISER) Kolkata, Mohanpur 741246, West Bengal, India.
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Źródło :
Inorganic chemistry [Inorg Chem] 2021 Apr 05; Vol. 60 (7), pp. 4342-4346. Date of Electronic Publication: 2021 Mar 12.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Cell Hypoxia/*drug effects
Liver Neoplasms/*drug therapy
Organoplatinum Compounds/*pharmacology
Orotic Acid/*pharmacology
Prodrugs/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Molecular Structure ; Organic Anion Transporters, Sodium-Independent/antagonists & inhibitors ; Organic Anion Transporters, Sodium-Independent/metabolism ; Organoplatinum Compounds/chemical synthesis ; Organoplatinum Compounds/chemistry ; Orotic Acid/chemistry ; Prodrugs/chemical synthesis ; Prodrugs/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
In Vitro Interaction of 5-Aminoorotic Acid and Its Gallium(III) Complex with Superoxide Radical, Generated by Two Model Systems.
Autorzy :
Todorov L; Department of Chemistry, Faculty of Pharmacy, Medical University-Sofia, 1000 Sofia, Bulgaria.
Traykova M; Department of Physics and Biophysics, Faculty of Medicine, Medical University-Sofia, 1431 Sofia, Bulgaria.
Saso L; Department of Physiology and Pharmacology 'Vittorio Erspamer', Faculty of Pharmacy and Medicine, Sapienza University, 00185 Rome, Italy.
Kostova I; Department of Chemistry, Faculty of Pharmacy, Medical University-Sofia, 1000 Sofia, Bulgaria.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Nov 23; Vol. 21 (22). Date of Electronic Publication: 2020 Nov 23.
Typ publikacji :
Journal Article
MeSH Terms :
Antioxidants/*pharmacology
Coordination Complexes/*pharmacology
Gallium/*pharmacology
Orotic Acid/*analogs & derivatives
Animals ; Antioxidants/chemistry ; Coordination Complexes/chemistry ; Free Radical Scavengers/blood ; Free Radicals/blood ; Gallium/chemistry ; Humans ; Orotic Acid/chemistry ; Orotic Acid/pharmacology ; Rats ; Superoxides/blood ; Xanthine Oxidase/blood
Czasopismo naukowe
Tytuł :
Evaluation of synergistic combination comprising magnesium orotate, menaquinone-7, and cholecalciferol for management of type 2 diabetes and dyslipidemia.
Autorzy :
Verma H; IKG Punjab Technical University, KapurthalaIndia, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Ropar, PunjabIndia, Overseas R&D Centre, Overseas HealthCare Pvt Ltd., Phillaur, PunjabIndia.
Garg R; IKG Punjab Technical University, KapurthalaIndia, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Ropar, PunjabIndia.
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Źródło :
Magnesium research [Magnes Res] 2020 Nov 01; Vol. 33 (4), pp. 88-105.
Typ publikacji :
Journal Article
MeSH Terms :
Cholecalciferol/*therapeutic use
Diabetes Mellitus, Experimental/*drug therapy
Dyslipidemias/*drug therapy
Hypoglycemic Agents/*therapeutic use
Orotic Acid/*analogs & derivatives
Vitamin K 2/*analogs & derivatives
Animals ; Cholecalciferol/administration & dosage ; Diabetes Mellitus, Experimental/chemically induced ; Diabetes Mellitus, Experimental/pathology ; Disease Models, Animal ; Dyslipidemias/chemically induced ; Dyslipidemias/pathology ; Hypoglycemic Agents/administration & dosage ; Male ; Niacinamide ; Orotic Acid/administration & dosage ; Orotic Acid/therapeutic use ; Rats ; Rats, Wistar ; Streptozocin ; Vitamin K 2/administration & dosage ; Vitamin K 2/therapeutic use
Czasopismo naukowe
Tytuł :
Structural, Electronic, and Electrostatic Determinants for Inhibitor Binding to Subsites S1 and S2 in SARS-CoV-2 Main Protease.
Autorzy :
Kneller DW; Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States.; National Virtual Biotechnology Laboratory, US Department of Energy, Washington, District of Columbia 20585, United States.
Li H; National Virtual Biotechnology Laboratory, US Department of Energy, Washington, District of Columbia 20585, United States.; Center for Nanophase Materials Sciences, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States.
Galanie S; National Virtual Biotechnology Laboratory, US Department of Energy, Washington, District of Columbia 20585, United States.; Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States.
Phillips G; Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States.; National Virtual Biotechnology Laboratory, US Department of Energy, Washington, District of Columbia 20585, United States.
Labbé A; National Virtual Biotechnology Laboratory, US Department of Energy, Washington, District of Columbia 20585, United States.; Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States.
Weiss KL; Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States.; National Virtual Biotechnology Laboratory, US Department of Energy, Washington, District of Columbia 20585, United States.
Zhang Q; Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States.; National Virtual Biotechnology Laboratory, US Department of Energy, Washington, District of Columbia 20585, United States.
Arnould MA; National Virtual Biotechnology Laboratory, US Department of Energy, Washington, District of Columbia 20585, United States.; Center for Nanophase Materials Sciences, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States.
Clyde A; National Virtual Biotechnology Laboratory, US Department of Energy, Washington, District of Columbia 20585, United States.; Data Science and Learning Division, Argonne National Laboratory, Lemont, Illinois 60439, United States.; Department of Computer Science, University of Chicago, Chicago, Illinois 60615, United States.
Ma H; National Virtual Biotechnology Laboratory, US Department of Energy, Washington, District of Columbia 20585, United States.; Data Science and Learning Division, Argonne National Laboratory, Lemont, Illinois 60439, United States.
Ramanathan A; National Virtual Biotechnology Laboratory, US Department of Energy, Washington, District of Columbia 20585, United States.; Data Science and Learning Division, Argonne National Laboratory, Lemont, Illinois 60439, United States.; Consortium for Advanced Science and Engineering, University of Chicago, Chicago, Illinois 60615, United States.
Jonsson CB; Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
Head MS; National Virtual Biotechnology Laboratory, US Department of Energy, Washington, District of Columbia 20585, United States.; Joint Institute for Biological Sciences, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States.
Coates L; National Virtual Biotechnology Laboratory, US Department of Energy, Washington, District of Columbia 20585, United States.; Second Target Station, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States.
Louis JM; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, Maryland 20892-0520, United States.
Bonnesen PV; National Virtual Biotechnology Laboratory, US Department of Energy, Washington, District of Columbia 20585, United States.; Center for Nanophase Materials Sciences, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States.
Kovalevsky A; Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States.; National Virtual Biotechnology Laboratory, US Department of Energy, Washington, District of Columbia 20585, United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Dec 09; Vol. 64 (23), pp. 17366-17383. Date of Electronic Publication: 2021 Oct 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Coronavirus 3C Proteases*
Protease Inhibitors*
Orotic Acid/analogs & derivatives ; Piperazines ; Protein Conformation ; Static Electricity
Czasopismo naukowe
Tytuł :
Protein-Ribofuranosyl Interactions Activate Orotidine 5'-Monophosphate Decarboxylase for Catalysis.
Autorzy :
Cristobal JR; Department of Chemistry, University at Buffalo, SUNY, Buffalo, New York 14260-3000, United States.
Brandão TAS; Department of Chemistry, ICEx, Federal University of Minas Gerais, Belo Horizonte, MG 31270-901, Brazil.
Reyes AC; Department of Chemistry, University at Buffalo, SUNY, Buffalo, New York 14260-3000, United States.
Richard JP; Department of Chemistry, University at Buffalo, SUNY, Buffalo, New York 14260-3000, United States.
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Źródło :
Biochemistry [Biochemistry] 2021 Nov 16; Vol. 60 (45), pp. 3362-3373. Date of Electronic Publication: 2021 Nov 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Orotidine-5'-Phosphate Decarboxylase/*metabolism
Uridine Monophosphate/*analogs & derivatives
Binding Sites ; Biophysical Phenomena ; Catalysis ; Cell Communication ; Erythritol/analogs & derivatives ; Hydroxides/chemistry ; Kinetics ; Orotic Acid/chemistry ; Orotidine-5'-Phosphate Decarboxylase/chemistry ; Orotidine-5'-Phosphate Decarboxylase/physiology ; Phagocytosis ; Phosphites ; Protein Domains ; Ribose/chemistry ; Sugar Phosphates ; Uridine Monophosphate/chemistry ; Uridine Monophosphate/metabolism
Czasopismo naukowe
Tytuł :
A Procedure to Design One-Pot Multi-enzyme System for Industrial CDP-Choline Production.
Autorzy :
Zheng C; College of Biotechnology and Pharmaceutical Engineering, National Engineering Technique Research Center for Biotechnology, Nanjing Tech University, No. 30, Puzhu South Road, 211816, Nanjing, China.; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, No. 5, Xinmofan Road, 210009, Nanjing, China.
Miao R; School of Life Sciences, Zhengzhou University, Zhengzhou, China.
Liu Y; College of Biotechnology and Pharmaceutical Engineering, National Engineering Technique Research Center for Biotechnology, Nanjing Tech University, No. 30, Puzhu South Road, 211816, Nanjing, China.; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, No. 5, Xinmofan Road, 210009, Nanjing, China.; Key Laboratory of Synthetic Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200032, China.
Cao Y; College of Biotechnology and Pharmaceutical Engineering, National Engineering Technique Research Center for Biotechnology, Nanjing Tech University, No. 30, Puzhu South Road, 211816, Nanjing, China.; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, No. 5, Xinmofan Road, 210009, Nanjing, China.
Liu D; College of Biotechnology and Pharmaceutical Engineering, National Engineering Technique Research Center for Biotechnology, Nanjing Tech University, No. 30, Puzhu South Road, 211816, Nanjing, China.; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, No. 5, Xinmofan Road, 210009, Nanjing, China.; Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, No. 30, Puzhu South Road, 211816, Nanjing, China.
Wang J; College of Biotechnology and Pharmaceutical Engineering, National Engineering Technique Research Center for Biotechnology, Nanjing Tech University, No. 30, Puzhu South Road, 211816, Nanjing, China. .; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, No. 5, Xinmofan Road, 210009, Nanjing, China. .; Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, No. 30, Puzhu South Road, 211816, Nanjing, China. .
Ying H; College of Biotechnology and Pharmaceutical Engineering, National Engineering Technique Research Center for Biotechnology, Nanjing Tech University, No. 30, Puzhu South Road, 211816, Nanjing, China. .; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, No. 5, Xinmofan Road, 210009, Nanjing, China. .; Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, No. 30, Puzhu South Road, 211816, Nanjing, China. .
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Źródło :
Applied biochemistry and biotechnology [Appl Biochem Biotechnol] 2021 Sep; Vol. 193 (9), pp. 2769-2780. Date of Electronic Publication: 2021 Jun 11.
Typ publikacji :
Journal Article
MeSH Terms :
Cytidine Diphosphate Choline/*chemical synthesis
Enzymes, Immobilized/*chemistry
Orotic Acid/*chemistry
Cytidine Diphosphate Choline/chemistry
Czasopismo naukowe
Tytuł :
Development of a pyrF -based counterselectable system for targeted gene deletion in Streptomyces rimosus .
Autorzy :
Yang Y; School of Life Sciences, North China University of Science and Technology, Tangshan 063210, China.
Sun Q; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Liu Y; School of Life Sciences, North China University of Science and Technology, Tangshan 063210, China.
Yin H; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Yang W; School of Life Sciences, North China University of Science and Technology, Tangshan 063210, China.
Wang Y; School of Life Sciences, North China University of Science and Technology, Tangshan 063210, China.
Liu Y; School of Life Sciences, North China University of Science and Technology, Tangshan 063210, China.
Li Y; School of Life Sciences, North China University of Science and Technology, Tangshan 063210, China.
Pang S; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Liu W; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Zhang Q; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Yuan F; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Qiu S; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Li J; Shengxue Dacheng Pharmaceutical Co., Ltd., Shijiazhuang 051430, China.
Wang X; Shengxue Dacheng Pharmaceutical Co., Ltd., Shijiazhuang 051430, China.
Fan K; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Wang W; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Li Z; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China. .
Yin S; School of Life Sciences, North China University of Science and Technology, Tangshan 063210, China. , .
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Źródło :
Journal of Zhejiang University. Science. B [J Zhejiang Univ Sci B] 2021 May 15; Vol. 22 (5), pp. 383-396.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Deletion*
Gene Knockout Techniques/*methods
Orotidine-5'-Phosphate Decarboxylase/*genetics
Streptomyces rimosus/*genetics
Genetic Complementation Test ; Orotic Acid/analogs & derivatives ; Orotic Acid/pharmacology ; Streptomyces rimosus/drug effects
Czasopismo naukowe
Tytuł :
Theoretical and Experimental Vibrational Characterization of Biologically Active Nd(III) Complex.
Autorzy :
Kostova I; Department of Chemistry, Faculty of Pharmacy, Medical University, 2 Dunav St., 1000 Sofia, Bulgaria.
Mojžiš J; Department of Pharmacology, Faculty of Medicine, P.J. Šafarik University, 04011 Košice, Slovakia.
Chiş V; Department of Biomolecular Physics, Faculty of Physics, Babeş-Bolyai University, 400084 Cluj-Napoca, Romania.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 May 06; Vol. 26 (9). Date of Electronic Publication: 2021 May 06.
Typ publikacji :
Journal Article
MeSH Terms :
Neodymium/*chemistry
Orotic Acid/*chemistry
Spectrophotometry, Infrared/*methods
A549 Cells ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Chelating Agents ; HeLa Cells ; Humans ; Jurkat Cells ; Ligands ; Models, Molecular ; Molecular Structure ; Sodium/chemistry ; Spectrum Analysis, Raman ; Vibration
Czasopismo naukowe
Tytuł :
The role of orotic acid measurement in routine newborn screening for urea cycle disorders.
Autorzy :
Staretz-Chacham O; Metabolic Clinic, Pediatric Division, Soroka University Medical Center, Ben Gurion University, Beer Sheva, Israel.
Daas S; National Newborn Screening Program, Ministry of Health, Tel-HaShomer, Ramat Gan, Israel.
Ulanovsky I; National Newborn Screening Program, Ministry of Health, Tel-HaShomer, Ramat Gan, Israel.
Blau A; National Newborn Screening Program, Ministry of Health, Tel-HaShomer, Ramat Gan, Israel.; Nursing Department, School of Health Sciences, Ariel University, Ariel, Israel.
Rostami N; National Newborn Screening Program, Ministry of Health, Tel-HaShomer, Ramat Gan, Israel.
Saraf-Levy T; National Newborn Screening Program, Ministry of Health, Tel-HaShomer, Ramat Gan, Israel.
Abu Salah N; Department of Neonatology, Red Crescent Society Hospital, Jerusalem, Israel.; Department of Neonatology, Shaare Zedek Medical Center, Jerusalem, Israel.
Anikster Y; Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel-Hashomer, Israel.; Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel.
Banne E; Genetics Institute, Kaplan Medical Center, Rehovot, Israel.
Dar D; Department of Clinical Biochemistry, Rambam Health Care Campus, Haifa, Israel.
Dumin E; Department of Clinical Biochemistry, Rambam Health Care Campus, Haifa, Israel.; Ruth & Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Fattal-Valevski A; Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel.; Pediatric Neurology Unit, Dana Children Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Falik-Zaccai T; Institute of Human Genetics, The Galilee Medical Center, Naharia, Israel.; The Azrieli Faculty of Medicine, Bar Ilan, Israel.
Hershkovitz E; Pediatric D Department, Soroka Medical Center, Beer Sheva, Israel.; Faculty of Health Sciences, Ben-Gurion University, Beer Sheva, Israel.
Josefsberg S; Genetics Institute, Kaplan Medical Center, Rehovot, Israel.
Khammash H; Department of Neonatology, Makassed Islamic Hospital, Jerusalem, Israel.
Keidar R; Pediatric Department, Shamir Medical Center (Assaf Harofeh), Zerifin, Israel, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Korman SH; Wilf Children's Hospital, Shaare Zedek Medical Center, Jerusalem, Israel.; Metabolic Unit, Ruth Rappaport Children's Hospital, Rambam Health Care Campus, Haifa, Israel.
Landau Y; Metabolic Disease Unit, Schneider Children's Medical Center of Israel, Tel Aviv University, Israel.
Lerman-Sagie T; Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel.; Pediatric Neurology Unit, Metabolic Neurogenetic Service, Wolfson Medical Center, Holon, Israel.
Mandel D; Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel.
Mandel H; Ruth & Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.; Metabolic Unit, Ruth Rappaport Children's Hospital, Rambam Health Care Campus, Haifa, Israel.
Marom R; Department of Neonatology, Dana Dwek Children's Hospital, Tel Aviv Medical Center, Affiliated to Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Morag I; Pediatric Department, Shamir Medical Center (Assaf Harofeh), Zerifin, Israel, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Nadir E; Ruth & Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.; Department of Neonatology, Hillel Yaffe Medical Center, Hadera, Israel.
Yosha-Orpaz N; Pediatric Neurology Unit, Metabolic Neurogenetic Service, Wolfson Medical Center, Holon, Israel.
Pode-Shakked B; Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel-Hashomer, Israel.; Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel.
Pras E; The Danek Gertner Institute of Human Genetics, Sheba Medical Center, Ramat Gan, Israel.; Department of Genetics, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Reznik-Wolf H; The Danek Gertner Institute of Human Genetics, Sheba Medical Center, Ramat Gan, Israel.
Saada A; Department of Genetics, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.; Hebrew University School of Medicine, Jerusalem, Israel.
Segel R; Hebrew University School of Medicine, Jerusalem, Israel.; Medical Genetics Institute, Shaare Zedek Medical Center, Jerusalem, Israel.
Shaag A; Department of Genetics, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Shaul Lotan N; Department of Genetics, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Spiegel R; Ruth & Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.; Department of Pediatrics B, Metabolic Service, Emek Medical Center, Afula, Israel.
Tal G; Metabolic Unit, Ruth Rappaport Children's Hospital, Rambam Health Care Campus, Haifa, Israel.
Vaisid T; Metabolic Laboratory, Sheba Medical Center, Tel-HaShomer, Ramat Gan, Israel.
Zeharia A; Metabolic Disease Unit, Schneider Children's Medical Center of Israel, Tel Aviv University, Israel.
Almashanu S; National Newborn Screening Program, Ministry of Health, Tel-HaShomer, Ramat Gan, Israel.
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Źródło :
Journal of inherited metabolic disease [J Inherit Metab Dis] 2021 May; Vol. 44 (3), pp. 606-617. Date of Electronic Publication: 2020 Nov 30.
Typ publikacji :
Journal Article
MeSH Terms :
Citrulline/*blood
Ornithine Carbamoyltransferase Deficiency Disease/*diagnosis
Orotic Acid/*blood
Urea Cycle Disorders, Inborn/*diagnosis
Dried Blood Spot Testing ; Female ; Humans ; Infant, Newborn ; Israel/epidemiology ; Male ; Neonatal Screening ; Ornithine Carbamoyltransferase Deficiency Disease/epidemiology ; Retrospective Studies ; Urea Cycle Disorders, Inborn/epidemiology
Czasopismo naukowe
Tytuł :
Orotic acid-treated hepatocellular carcinoma cells resist steatosis by modification of fatty acid metabolism.
Autorzy :
Matilainen J; Faculty of Health Sciences, School of Medicine, Institute of Biomedicine, University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland. .
Mustonen AM; Faculty of Health Sciences, School of Medicine, Institute of Biomedicine, University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland.; Faculty of Science and Forestry, Department of Environmental and Biological Sciences, University of Eastern Finland, P.O. Box 111, FI-80101, Joensuu, Finland.
Rilla K; Faculty of Health Sciences, School of Medicine, Institute of Biomedicine, University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland.
Käkelä R; Faculty of Biological and Environmental Sciences, Molecular and Integrative Biosciences Research Programme, University of Helsinki, P.O. Box 65, FI-00014, Helsinki, Finland.; Helsinki Institute for Life Science (HiLIFE), Helsinki University Lipidomics Unit (HiLIPID), University of Helsinki, P.O. Box 65, FI-00014, Helsinki, Finland.
Sihvo SP; Faculty of Biological and Environmental Sciences, Molecular and Integrative Biosciences Research Programme, University of Helsinki, P.O. Box 65, FI-00014, Helsinki, Finland.; Helsinki Institute for Life Science (HiLIFE), Helsinki University Lipidomics Unit (HiLIPID), University of Helsinki, P.O. Box 65, FI-00014, Helsinki, Finland.
Nieminen P; Faculty of Health Sciences, School of Medicine, Institute of Biomedicine, University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland.
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Źródło :
Lipids in health and disease [Lipids Health Dis] 2020 Apr 13; Vol. 19 (1), pp. 70. Date of Electronic Publication: 2020 Apr 13.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Hepatocellular/*drug therapy
Carcinoma, Hepatocellular/*metabolism
Fatty Acids/*metabolism
Liver Neoplasms/*drug therapy
Liver Neoplasms/*metabolism
Non-alcoholic Fatty Liver Disease/*metabolism
Orotic Acid/*therapeutic use
Carcinoma, Hepatocellular/genetics ; Discriminant Analysis ; Gene Expression Regulation, Neoplastic/drug effects ; Hep G2 Cells ; Humans ; Inflammation/pathology ; Lipogenesis/drug effects ; Lipopolysaccharides ; Liver Neoplasms/genetics ; Orotic Acid/pharmacology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Stearoyl-CoA Desaturase/genetics ; Stearoyl-CoA Desaturase/metabolism ; Triglycerides/metabolism
Czasopismo naukowe
Tytuł :
Isolated Orotic Aciduria in an 11-Year-Old Boy.
Autorzy :
Vakili H; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX.
Umaña LA; Division of Genetics and Metabolism, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX.
Patel K; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX.
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Źródło :
Clinical chemistry [Clin Chem] 2020 Feb 01; Vol. 66 (2), pp. 396-397.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Calcium/*metabolism
Dietary Supplements/*adverse effects
Orotic Acid/*metabolism
Bone Diseases, Metabolic/drug therapy ; Child ; Developmental Disabilities/genetics ; Humans ; Male ; Orotate Phosphoribosyltransferase/deficiency ; Orotate Phosphoribosyltransferase/metabolism ; Orotic Acid/adverse effects ; Orotidine-5'-Phosphate Decarboxylase/deficiency ; Orotidine-5'-Phosphate Decarboxylase/metabolism ; Purine-Pyrimidine Metabolism, Inborn Errors/diagnosis ; Purine-Pyrimidine Metabolism, Inborn Errors/metabolism
SCR Disease Name :
Orotic Aciduria II; Oroticaciduria 1
Czasopismo naukowe
Tytuł :
Correction of a urea cycle defect after ex vivo gene editing of human hepatocytes.
Autorzy :
Zabulica M; Department of Laboratory Medicine, Karolinska Institutet, 141 52 Huddinge, Sweden.
Srinivasan RC; Department of Laboratory Medicine, Karolinska Institutet, 141 52 Huddinge, Sweden.
Akcakaya P; Discovery Sciences, BioPharmaceuticals R&D Unit, AstraZeneca, Gothenburg, Sweden.
Allegri G; Division of Metabolism and Children's Research Center, University Children's Hospital, Zürich, Switzerland.
Bestas B; Discovery Sciences, BioPharmaceuticals R&D Unit, AstraZeneca, Gothenburg, Sweden.
Firth M; Discovery Sciences, BioPharmaceuticals R&D Unit, AstraZeneca, Cambridge, UK.
Hammarstedt C; Department of Laboratory Medicine, Karolinska Institutet, 141 52 Huddinge, Sweden.
Jakobsson T; Department of Laboratory Medicine, Karolinska Institutet, 141 52 Huddinge, Sweden.
Jakobsson T; Department of Clinical Sciences Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
Ellis E; Department of Clinical Sciences Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
Jorns C; Department of Clinical Sciences Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
Makris G; Division of Metabolism and Children's Research Center, University Children's Hospital, Zürich, Switzerland.
Scherer T; Division of Metabolism and Children's Research Center, University Children's Hospital, Zürich, Switzerland.
Rimann N; Division of Metabolism and Children's Research Center, University Children's Hospital, Zürich, Switzerland.
van Zuydam NR; Department of Quantitative Biology, Discovery Sciences, R&D BioPharmaceuticals, AstraZeneca, Gothenburg, Sweden.
Gramignoli R; Department of Laboratory Medicine, Karolinska Institutet, 141 52 Huddinge, Sweden.
Forslöw A; Discovery Sciences, BioPharmaceuticals R&D Unit, AstraZeneca, Gothenburg, Sweden.
Engberg S; Discovery Sciences, BioPharmaceuticals R&D Unit, AstraZeneca, Gothenburg, Sweden.
Maresca M; Discovery Sciences, BioPharmaceuticals R&D Unit, AstraZeneca, Gothenburg, Sweden.
Rooyackers O; Department of Clinical Sciences Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
Thöny B; Division of Metabolism and Children's Research Center, University Children's Hospital, Zürich, Switzerland.
Häberle J; Division of Metabolism and Children's Research Center, University Children's Hospital, Zürich, Switzerland.
Rosen B; Discovery Sciences, BioPharmaceuticals R&D Unit, AstraZeneca, Cambridge, UK.
Strom SC; Department of Laboratory Medicine, Karolinska Institutet, 141 52 Huddinge, Sweden. Electronic address: .
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Źródło :
Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2021 May 05; Vol. 29 (5), pp. 1903-1917. Date of Electronic Publication: 2021 Jan 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Gene Editing/*methods
Hepatocytes/*transplantation
Ornithine Carbamoyltransferase/*genetics
Ornithine Carbamoyltransferase Deficiency Disease/*therapy
Adult ; Aged ; Ammonia/metabolism ; Animals ; Cells, Cultured ; Child ; Disease Models, Animal ; Female ; Gene Expression Regulation ; Hepatocytes/chemistry ; Hepatocytes/cytology ; Humans ; Introns ; Male ; Mice ; Ornithine Carbamoyltransferase Deficiency Disease/genetics ; Orotic Acid/urine ; RNA Splicing
Czasopismo naukowe
Tytuł :
Development, optimization and characterization of chewable tablet containing synergistic combination of magnesium orotate dihydrate with cholecalciferol and menaquinone-7 for management of hyperglycemia and its pharmacokinetic study.
Autorzy :
Verma H; IKG Punjab Technical University, Kapurthala, India, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Ropar, Punjab, India, Overseas R & D Centre, Overseas HealthCare Pvt Ltd., Phillaur, Punjab, India.
Garg R; IKG Punjab Technical University, Kapurthala, India, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Ropar, Punjab, India, Institute of Pharmaceutical Sciences, IET Bhaddal Technical Campus, Ropar, Punjab, India.
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Źródło :
Magnesium research [Magnes Res] 2021 May 01; Vol. 34 (2), pp. 43-63.
Typ publikacji :
Journal Article
MeSH Terms :
Cholecalciferol*
Hyperglycemia*
Animals ; Cross-Over Studies ; Male ; Orotic Acid/analogs & derivatives ; Rats ; Rats, Wistar ; Tablets ; Vitamin K 2/analogs & derivatives
Czasopismo naukowe
Tytuł :
Humanized liver mouse model with transplanted human hepatocytes from patients with ornithine transcarbamylase deficiency.
Autorzy :
Sugahara G; Research and Development Department, PhoenixBio Co., Ltd, Higashi-Hiroshima, Japan.
Yamasaki C; Research and Development Department, PhoenixBio Co., Ltd, Higashi-Hiroshima, Japan.
Yanagi A; Research and Development Department, PhoenixBio Co., Ltd, Higashi-Hiroshima, Japan.
Furukawa S; Research and Development Department, PhoenixBio Co., Ltd, Higashi-Hiroshima, Japan.
Ogawa Y; Research and Development Department, PhoenixBio Co., Ltd, Higashi-Hiroshima, Japan.
Fukuda A; National Center for Child Health and Development, Tokyo, Japan.
Enosawa S; Division for Advanced Medical Sciences, National Center for Child Health and Development, Tokyo, Japan.
Umezawa A; Regenerative Medicine, National Center for Child Health and Development, Tokyo, Japan.
Ishida Y; Research and Development Department, PhoenixBio Co., Ltd, Higashi-Hiroshima, Japan.; Research Center for Hepatology and Gastroenterology, Hiroshima University, Hiroshima, Japan.
Tateno C; Research and Development Department, PhoenixBio Co., Ltd, Higashi-Hiroshima, Japan.; Research Center for Hepatology and Gastroenterology, Hiroshima University, Hiroshima, Japan.
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Źródło :
Journal of inherited metabolic disease [J Inherit Metab Dis] 2021 May; Vol. 44 (3), pp. 618-628. Date of Electronic Publication: 2020 Dec 30.
Typ publikacji :
Journal Article
MeSH Terms :
Hepatocytes/*transplantation
Ornithine Carbamoyltransferase/*genetics
Ornithine Carbamoyltransferase Deficiency Disease/*therapy
Ammonia/blood ; Animals ; Child, Preschool ; Disease Models, Animal ; Female ; Gene Expression Regulation ; Hepatocytes/chemistry ; Hepatocytes/cytology ; Humans ; Infant ; Male ; Mice ; Ornithine Carbamoyltransferase Deficiency Disease/genetics ; Orotic Acid/urine
Czasopismo naukowe
Tytuł :
Multicomponent Approach to Libraries of Substituted Dihydroorotic Acid Amides.
Autorzy :
Bellucci MC; Department of Food, Environmental and Nutritional Sciences , Università degli Studi di Milano , via Celoria 2 , 20133 Milano , Italy.
Sacchetti A; Department of Chemistry, Material and Chemical Engineer 'Giulio Natta' , Politecnico di Milano , via Mancinelli 7 , 20131 Milano , Italy.
Volonterio A; Department of Chemistry, Material and Chemical Engineer 'Giulio Natta' , Politecnico di Milano , via Mancinelli 7 , 20131 Milano , Italy.
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Źródło :
ACS combinatorial science [ACS Comb Sci] 2019 Oct 14; Vol. 21 (10), pp. 705-715. Date of Electronic Publication: 2019 Sep 05.
Typ publikacji :
Journal Article
MeSH Terms :
Combinatorial Chemistry Techniques*
Amides/*chemical synthesis
Orotic Acid/*analogs & derivatives
Small Molecule Libraries/*chemical synthesis
Amides/chemistry ; Molecular Structure ; Orotic Acid/chemical synthesis ; Orotic Acid/chemistry ; Small Molecule Libraries/chemistry
Czasopismo naukowe
Tytuł :
Early pregnancy metabolites predict gestational diabetes mellitus: implications for fetal programming.
Autorzy :
Koos BJ; Departments of Obstetrics and Gynecology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA. Electronic address: .
Gornbein JA; Department of Medicine, Computational Core, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA; Department of Medicine, Statistical Core, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA.
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Źródło :
American journal of obstetrics and gynecology [Am J Obstet Gynecol] 2021 Feb; Vol. 224 (2), pp. 215.e1-215.e7. Date of Electronic Publication: 2020 Jul 31.
Typ publikacji :
Journal Article; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Gestational Age*
Metabolomics*
Diabetes, Gestational/*urine
Adult ; Alanine/analogs & derivatives ; Alanine/urine ; Arginine/analogs & derivatives ; Arginine/urine ; Carnitine/analogs & derivatives ; Carnitine/urine ; Case-Control Studies ; Diabetes, Gestational/diagnosis ; Diabetes, Gestational/therapy ; Diet Therapy ; Dopamine/urine ; Early Diagnosis ; Epigenesis, Genetic ; Female ; Fetal Development/genetics ; Glucose Tolerance Test ; Glucuronides/urine ; Humans ; Hypoglycemic Agents/therapeutic use ; Lactones/urine ; Lysine/analogs & derivatives ; Lysine/urine ; Meglutol/analogs & derivatives ; Meglutol/urine ; Neopterin/analogs & derivatives ; Neopterin/urine ; Orotic Acid/analogs & derivatives ; Orotic Acid/urine ; Phenols/urine ; Pregnancy ; Ribonucleosides/urine ; Sulfides/urine
Czasopismo naukowe
Tytuł :
Pharmacokinetic changes of clozapine and norclozapine in a rat model of non-alcoholic fatty liver disease induced by orotic acid.
Autorzy :
Li Z; College of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea, Bucheon, South Korea.
Lee SH; College of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea, Bucheon, South Korea.
Jeong HJ; College of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea, Bucheon, South Korea.
Kang HE; College of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea, Bucheon, South Korea.
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Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Mar; Vol. 51 (3), pp. 324-334. Date of Electronic Publication: 2020 Nov 29.
Typ publikacji :
Journal Article
MeSH Terms :
Clozapine/*analogs & derivatives
Clozapine/*pharmacokinetics
Cytochrome P-450 Enzyme System/*metabolism
Non-alcoholic Fatty Liver Disease/*enzymology
Animals ; Cytochrome P-450 CYP1A1/metabolism ; Cytochrome P-450 CYP1A2/metabolism ; Non-alcoholic Fatty Liver Disease/chemically induced ; Orotic Acid ; Rats
Czasopismo naukowe
Tytuł :
МЕХАНОМОДИФИЦИРОВАННАЯ ФОРМА ОРОТОВОЙ КИСЛОТЫ В КОРРЕКЦИИ ГЕПАТОПАТИИ, ВЫЗВАННОЙ ГИПЕРГОМОЦИСТЕИНЕМИЕЙ.
Autorzy :
Пазиненко, К. А.
Сметанина, М. В.
Чучкова, Н. Н.
Канунникова, О. М.
Кормилина, Н. В.
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Alternatywny tytuł :
MECHANO-MODIFIED FORM OF OROTIC ACID IN THE CORRECTION OF HEPATOPATHY CAUSED BY HYPERHOMOCYSTEINEMIA.
Źródło :
Molecular medicine. 2021, Vol. 19 Issue 1, p35-40. 6p.
Czasopismo naukowe

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