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Tytuł :
Carbonyl reduction pathway in hepatic in vitro metabolism of anthracyclines: Impact of structure on biotransformation rate.
Autorzy :
Piska K; Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9 St., 30-638, Kraków, Poland. Electronic address: .
Jamrozik M; Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9 St., 30-638, Kraków, Poland.
Koczurkiewicz-Adamczyk P; Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9 St., 30-638, Kraków, Poland.
Bucki A; Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9 St., 30-638, Kraków, Poland.
Żmudzki P; Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9 St., 30-638, Kraków, Poland.
Kołaczkowski M; Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9 St., 30-638, Kraków, Poland.
Pękala E; Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9 St., 30-638, Kraków, Poland.
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Źródło :
Toxicology letters [Toxicol Lett] 2021 May 15; Vol. 342, pp. 50-57. Date of Electronic Publication: 2021 Feb 10.
Typ publikacji :
Journal Article
MeSH Terms :
Aclarubicin/*metabolism
Cytosol/*metabolism
Doxorubicin/*analogs & derivatives
Hepatocytes/*metabolism
Oxidoreductases/*metabolism
Aclarubicin/chemistry ; Alcohol Oxidoreductases/genetics ; Alcohol Oxidoreductases/metabolism ; Aldo-Keto Reductase Family 1 Member C3/genetics ; Aldo-Keto Reductase Family 1 Member C3/metabolism ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/metabolism ; Binding Sites ; Biotransformation ; Doxorubicin/chemistry ; Doxorubicin/metabolism ; Gene Expression Regulation, Enzymologic/drug effects ; Humans ; Models, Molecular ; Molecular Docking Simulation ; Molecular Structure ; Protein Conformation
Czasopismo naukowe
Tytuł :
Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2.
Autorzy :
Xiong R; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Zhang L; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China.
Li S; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Sun Y; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China.
Ding M; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Wang Y; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, 430072, China.
Zhao Y; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, 430072, China.
Wu Y; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China.
Shang W; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China.
Jiang X; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China.
Shan J; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Shen Z; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Tong Y; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Xu L; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Chen Y; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, 430072, China.
Liu Y; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, 430072, China.
Zou G; CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
Lavillete D; CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
Zhao Z; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Wang R; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Zhu L; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Xiao G; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China.
Lan K; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, 430072, China.
Li H; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China. .
Xu K; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, 430072, China. .; CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China. .
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Źródło :
Protein & cell [Protein Cell] 2020 Oct; Vol. 11 (10), pp. 723-739. Date of Electronic Publication: 2020 Aug 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Pandemics*
Antiviral Agents/*pharmacology
Coronavirus Infections/*drug therapy
Oxidoreductases/*antagonists & inhibitors
Pneumonia, Viral/*drug therapy
RNA Viruses/*drug effects
Thiazoles/*pharmacology
Animals ; Antiviral Agents/therapeutic use ; Betacoronavirus/drug effects ; Betacoronavirus/physiology ; Binding Sites/drug effects ; COVID-19 ; Cell Line ; Coronavirus Infections/virology ; Crotonates/pharmacology ; Cytokine Release Syndrome/drug therapy ; Drug Evaluation, Preclinical ; Gene Knockout Techniques ; Humans ; Influenza A virus/drug effects ; Leflunomide/pharmacology ; Mice ; Mice, Inbred BALB C ; Orthomyxoviridae Infections/drug therapy ; Oseltamivir/therapeutic use ; Oxidoreductases/metabolism ; Oxidoreductases Acting on CH-CH Group Donors ; Pneumonia, Viral/virology ; Protein Binding/drug effects ; Pyrimidines/biosynthesis ; RNA Viruses/physiology ; SARS-CoV-2 ; Structure-Activity Relationship ; Thiazoles/therapeutic use ; Toluidines/pharmacology ; Ubiquinone/metabolism ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
The Emerging Role of GSNOR in Oxidative Stress Regulation.
Autorzy :
Li B; MOE Key Laboratory of Environment Remediation and Ecological Health, College of Environmental and Resource Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, China. Electronic address: .
Sun C; MOE Key Laboratory of Environment Remediation and Ecological Health, College of Environmental and Resource Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, China.
Lin X; MOE Key Laboratory of Environment Remediation and Ecological Health, College of Environmental and Resource Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, China. Electronic address: .
Busch W; Plant Biology Laboratory and Integrative Biology Laboratory, Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA.
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Źródło :
Trends in plant science [Trends Plant Sci] 2021 Feb; Vol. 26 (2), pp. 156-168. Date of Electronic Publication: 2020 Sep 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Aldehyde Oxidoreductases*/metabolism
Oxidoreductases*
Nitric Oxide ; Oxidative Stress ; Reactive Nitrogen Species ; Stress, Physiological
Czasopismo naukowe
Tytuł :
Potential treatment of COVID-19 by inhibitors of human dihydroorotate dehydrogenase.
Autorzy :
Xu Y; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Jiang H; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. .; University of Chinese Academy of Sciences, Beijing, 100049, China. .; Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. .
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Źródło :
Protein & cell [Protein Cell] 2020 Oct; Vol. 11 (10), pp. 699-702.
Typ publikacji :
Journal Article
MeSH Terms :
Betacoronavirus*
Pandemics*
Coronavirus Infections/*drug therapy
Enzyme Inhibitors/*therapeutic use
Oxidoreductases/*antagonists & inhibitors
Pneumonia, Viral/*drug therapy
Animals ; COVID-19 ; Drug Discovery ; Drug Evaluation, Preclinical ; Humans ; Mice ; Molecular Structure ; Orthomyxoviridae Infections/drug therapy ; Oseltamivir/therapeutic use ; Oxidoreductases Acting on CH-CH Group Donors ; Pyrimidines/biosynthesis ; SARS-CoV-2
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Single-Point Mutant Inverts the Stereoselectivity of a Carbonyl Reductase toward β-Ketoesters with Enhanced Activity.
Autorzy :
Li A; School of Life Sciences, Northwestern Polytechnical University, 710072, Xi'an, China.; Research & Development Institute in Shenzhen, Northwestern Polytechnical University, 518057, Shenzhen, China.
Wang T; School of Life Sciences, Northwestern Polytechnical University, 710072, Xi'an, China.; Research & Development Institute in Shenzhen, Northwestern Polytechnical University, 518057, Shenzhen, China.
Tian Q; School of Life Sciences, Northwestern Polytechnical University, 710072, Xi'an, China.; Research & Development Institute in Shenzhen, Northwestern Polytechnical University, 518057, Shenzhen, China.
Yang X; Department of Chemistry, University of California, One Shields Avenue, Davis, California, 95616, United States.
Yin D; School of Life Sciences, Northwestern Polytechnical University, 710072, Xi'an, China.; Research & Development Institute in Shenzhen, Northwestern Polytechnical University, 518057, Shenzhen, China.
Qin Y; School of Life Sciences, Northwestern Polytechnical University, 710072, Xi'an, China.
Zhang L; School of Life Sciences, Northwestern Polytechnical University, 710072, Xi'an, China.; Research & Development Institute in Shenzhen, Northwestern Polytechnical University, 518057, Shenzhen, China.
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Źródło :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2021 Apr 07; Vol. 27 (20), pp. 6283-6294. Date of Electronic Publication: 2021 Mar 07.
Typ publikacji :
Journal Article
MeSH Terms :
Alcohol Oxidoreductases*/genetics
Alcohol Oxidoreductases*/metabolism
Alcohols*
Ketones ; Stereoisomerism ; Substrate Specificity
Czasopismo naukowe
Tytuł :
A cytochrome c is the natural electron acceptor for nicotine oxidoreductase.
Autorzy :
Dulchavsky M; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI, USA.; Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI, USA.
Clark CT; Department of Chemistry, Western Michigan University, Kalamazoo, MI, USA.
Bardwell JCA; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI, USA. .; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA. .
Stull F; Department of Chemistry, Western Michigan University, Kalamazoo, MI, USA. .
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Źródło :
Nature chemical biology [Nat Chem Biol] 2021 Mar; Vol. 17 (3), pp. 344-350. Date of Electronic Publication: 2021 Jan 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Proteins/*chemistry
Cytochromes c/*chemistry
Flavin-Adenine Dinucleotide/*chemistry
Nicotine/*chemistry
Oxidoreductases/*chemistry
Pseudomonas putida/*chemistry
Alkaloids/chemistry ; Alkaloids/metabolism ; Animals ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Binding Sites ; Biotransformation ; Cattle ; Cloning, Molecular ; Cytochromes c/genetics ; Cytochromes c/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Flavin-Adenine Dinucleotide/metabolism ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Kinetics ; Models, Molecular ; Nicotine/metabolism ; Oxidation-Reduction ; Oxidoreductases/genetics ; Oxidoreductases/metabolism ; Protein Binding ; Protein Conformation ; Protein Interaction Domains and Motifs ; Protein Multimerization ; Pseudomonas putida/enzymology ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Structural Homology, Protein ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Formate-Dependent Heterodisulfide Reduction in a Methanomicrobiales Archaeon.
Autorzy :
Abdul Halim MF; Department of Plant and Microbial Biology, University of Minnesota, Twin Cities, St. Paul, Minnesota, USA.
Day LA; Department of Plant and Microbial Biology, University of Minnesota, Twin Cities, St. Paul, Minnesota, USA.
Costa KC; Department of Plant and Microbial Biology, University of Minnesota, Twin Cities, St. Paul, Minnesota, USA .
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Źródło :
Applied and environmental microbiology [Appl Environ Microbiol] 2021 Feb 26; Vol. 87 (6). Date of Electronic Publication: 2021 Feb 26 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Methanomicrobiales*/genetics
Methanomicrobiales*/growth & development
Methanomicrobiales*/metabolism
Oxidoreductases*/genetics
Oxidoreductases*/metabolism
Formates/*metabolism
Oxidation-Reduction
Czasopismo naukowe
Tytuł :
Discovery of an ene-reductase for initiating flavone and flavonol catabolism in gut bacteria.
Autorzy :
Yang G; CAS-Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, 200032, China.; University of Chinese Academy of Sciences, Beijing, China.
Hong S; University of Chinese Academy of Sciences, Beijing, China.; National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, 200032, China.
Yang P; CAS-Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, 200032, China.; University of Chinese Academy of Sciences, Beijing, China.
Sun Y; CAS-Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, 200032, China.
Wang Y; CAS-Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, 200032, China.
Zhang P; National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, 200032, China.
Jiang W; CAS-Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, 200032, China. .
Gu Y; CAS-Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, 200032, China. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 04; Vol. 12 (1), pp. 790. Date of Electronic Publication: 2021 Feb 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Proteins/*metabolism
Flavones/*metabolism
Flavonols/*metabolism
Gastrointestinal Microbiome/*physiology
Oxidoreductases/*metabolism
Bacterial Proteins/genetics ; Bacterial Proteins/isolation & purification ; Bacterial Proteins/ultrastructure ; Clostridiales/enzymology ; Clostridiales/genetics ; Crystallography, X-Ray ; Oxidoreductases/genetics ; Oxidoreductases/isolation & purification ; Oxidoreductases/ultrastructure ; Phylogeny ; Recombinant Proteins/genetics ; Recombinant Proteins/isolation & purification ; Recombinant Proteins/metabolism ; Recombinant Proteins/ultrastructure
SCR Organism :
Flavonifractor plautii
Czasopismo naukowe
Tytuł :
MiR-15b and miR-16 suppress TGF-β1-induced proliferation and fibrogenesis by regulating LOXL1 in hepatic stellate cells.
Autorzy :
Ma L; Department of Infectious Diseases, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou 450003, China.
Liu J; Department of Infectious Diseases, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou 450003, China.
Xiao E; Department of Infectious Diseases, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou 450003, China.
Ning H; Department of Infectious Diseases, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou 450003, China.
Li K; Department of Infectious Diseases, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou 450003, China.
Shang J; Department of Infectious Diseases, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou 450003, China.
Kang Y; Department of Infectious Diseases, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou 450003, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Apr 01; Vol. 270, pp. 119144. Date of Electronic Publication: 2021 Feb 02.
Typ publikacji :
Journal Article
MeSH Terms :
Amino Acid Oxidoreductases/*genetics
MicroRNAs/*genetics
3' Untranslated Regions/genetics ; Amino Acid Oxidoreductases/metabolism ; Cell Line, Tumor ; Cell Proliferation/genetics ; Collagen Type I/metabolism ; Gene Expression/genetics ; Gene Expression Regulation/genetics ; Hepatic Stellate Cells/metabolism ; Humans ; Liver Cirrhosis/genetics ; Liver Cirrhosis/metabolism ; Liver Cirrhosis/pathology ; MicroRNAs/metabolism ; Phosphorylation ; Signal Transduction/drug effects ; Smad2 Protein/metabolism ; Smad3 Protein/metabolism ; Transforming Growth Factor beta1/metabolism
Czasopismo naukowe
Tytuł :
A comprehensive drug repurposing study for COVID19 treatment: novel putative dihydroorotate dehydrogenase inhibitors show association to serotonin-dopamine receptors.
Autorzy :
Berber B; Eskisehir Technical University, Department of Biology.
Doluca O; Massey University, New Zealand.
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Źródło :
Briefings in bioinformatics [Brief Bioinform] 2021 Mar 22; Vol. 22 (2), pp. 1023-1037.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Repositioning*
Antiviral Agents/*pharmacology
Enzyme Inhibitors/*pharmacology
Oxidoreductases Acting on CH-CH Group Donors/*antagonists & inhibitors
Receptors, Dopamine/*drug effects
Receptors, Serotonin/*drug effects
COVID-19/drug therapy ; Computer Simulation ; Humans ; Molecular Docking Simulation ; Oxidoreductases Acting on CH-CH Group Donors/chemistry ; SARS-CoV-2
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Rid Enhances the 6-Hydroxypseudooxynicotine Dehydrogenase Reaction in Nicotine Degradation by Agrobacterium tumefaciens S33.
Autorzy :
Shang J; State Key Laboratory of Microbial Technology, Microbial Technology Institute, Shandong University, Qingdao, People's Republic of China.
Wang X; State Key Laboratory of Microbial Technology, Microbial Technology Institute, Shandong University, Qingdao, People's Republic of China.
Zhang M; State Key Laboratory of Microbial Technology, Microbial Technology Institute, Shandong University, Qingdao, People's Republic of China.
Wang R; State Key Laboratory of Microbial Technology, Microbial Technology Institute, Shandong University, Qingdao, People's Republic of China.
Zhang C; State Key Laboratory of Microbial Technology, Microbial Technology Institute, Shandong University, Qingdao, People's Republic of China.
Huang H; Institute of Basic Medicine, Shandong First Medical University & Shandong Academy of Medical Science, Jinan, People's Republic of China.
Wang S; State Key Laboratory of Microbial Technology, Microbial Technology Institute, Shandong University, Qingdao, People's Republic of China .
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Źródło :
Applied and environmental microbiology [Appl Environ Microbiol] 2021 Mar 11; Vol. 87 (7). Date of Electronic Publication: 2021 Mar 11 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Agrobacterium tumefaciens/*genetics
Bacterial Proteins/*genetics
Nicotine/*metabolism
Oxidoreductases/*genetics
Agrobacterium tumefaciens/metabolism ; Bacterial Proteins/metabolism ; Oxidoreductases/metabolism
Czasopismo naukowe
Tytuł :
Structural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate production.
Autorzy :
Venskutonytė R; Experimental Medical Science, Medical Structural Biology, BMC C13, Lund University, Lund, Sweden.
Koh A; Department of Molecular and Clinical Medicine/Wallenberg Laboratory, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.; Precision Medicine, Samsung Biomedical Research Institute, Samsung Medical Center, School of Medicine, Sungkyunkwan University (SKKU), Suwon, Republic of Korea.
Stenström O; Biophysical Chemistry, Center for Molecular Protein Science, Department of Chemistry, Lund University, Lund, Sweden.
Khan MT; Department of Molecular and Clinical Medicine/Wallenberg Laboratory, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
Lundqvist A; Department of Molecular and Clinical Medicine/Wallenberg Laboratory, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
Akke M; Biophysical Chemistry, Center for Molecular Protein Science, Department of Chemistry, Lund University, Lund, Sweden.
Bäckhed F; Department of Molecular and Clinical Medicine/Wallenberg Laboratory, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.; Region Västra Götaland, Sahlgrenska University Hospital, Department of Clinical Physiology, Gothenburg, Sweden.; Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Lindkvist-Petersson K; Experimental Medical Science, Medical Structural Biology, BMC C13, Lund University, Lund, Sweden. .; LINXS - Lund Institute of Advanced Neutron and X-ray Science, Lund, Sweden. .
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Źródło :
Nature communications [Nat Commun] 2021 Mar 01; Vol. 12 (1), pp. 1347. Date of Electronic Publication: 2021 Mar 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Imidazoles/*metabolism
Oxidoreductases/*metabolism
Shewanella/*enzymology
Urocanic Acid/*metabolism
Arginine/metabolism ; Catalytic Domain ; Flavin-Adenine Dinucleotide/metabolism ; Imidazoles/chemistry ; Kinetics ; Ligands ; Models, Molecular ; Oxidoreductases/chemistry ; Protein Conformation ; Protein Domains ; Substrate Specificity ; Thermodynamics ; Urocanic Acid/chemistry
SCR Organism :
Shewanella oneidensis
Czasopismo naukowe
Tytuł :
Role of mitochondrial alternative oxidase in the regulation of cellular homeostasis during development of photosynthetic function in greening leaves.
Autorzy :
Garmash EV; Institute of Biology, Komi Scientific Centre, Ural Branch, Russian Academy of Sciences, Syktyvkar, 167982, Russian Federation.
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Źródło :
Plant biology (Stuttgart, Germany) [Plant Biol (Stuttg)] 2021 Mar; Vol. 23 (2), pp. 221-228. Date of Electronic Publication: 2021 Jan 13.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Homeostasis*
Mitochondrial Proteins*/metabolism
Oxidoreductases*/metabolism
Plant Leaves*/enzymology
Plant Leaves*/metabolism
Plant Proteins*/metabolism
Plants*/enzymology
Electron Transport
Czasopismo naukowe
Tytuł :
[Methanol dehydrogenase, a key enzyme of one-carbon metabolism: a review].
Autorzy :
Fan L; School of Life Sciences, University of Science and Technology of China, Hefei 230026, Anhui, China.; Key Laboratory of Systems Microbial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.
Wang Y; Key Laboratory of Systems Microbial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.
Zheng P; School of Life Sciences, University of Science and Technology of China, Hefei 230026, Anhui, China.; Key Laboratory of Systems Microbial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.
Sun J; School of Life Sciences, University of Science and Technology of China, Hefei 230026, Anhui, China.; Key Laboratory of Systems Microbial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.
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Źródło :
Sheng wu gong cheng xue bao = Chinese journal of biotechnology [Sheng Wu Gong Cheng Xue Bao] 2021 Feb 25; Vol. 37 (2), pp. 530-540.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Alcohol Oxidoreductases*/genetics
Methanol*
Carbon ; Methane
Czasopismo naukowe
Tytuł :
Light-Activated Electron Transfer and Catalytic Mechanism of Carnitine Oxidation by Rieske-Type Oxygenase from Human Microbiota.
Autorzy :
Shanmugam M; Manchester Institute of Biotechnology (MIB) & Photon Science Institute (PSI), University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK.
Quareshy M; School of Life Sciences, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK.
Cameron AD; School of Life Sciences, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK.
Bugg TDH; Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK.
Chen Y; School of Life Sciences, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK.
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Źródło :
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2021 Feb 23; Vol. 60 (9), pp. 4529-4534. Date of Electronic Publication: 2020 Dec 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Light*
Microbiota*
Bacterial Proteins/*metabolism
Carnitine/*metabolism
Oxidoreductases/*metabolism
Acinetobacter baumannii/enzymology ; Acinetobacter baumannii/isolation & purification ; Bacterial Proteins/genetics ; Carnitine/chemistry ; Catalysis ; Electron Spin Resonance Spectroscopy ; Electron Transport ; Humans ; Iron-Sulfur Proteins/chemistry ; Iron-Sulfur Proteins/genetics ; Iron-Sulfur Proteins/metabolism ; Mutagenesis, Site-Directed ; NAD/chemistry ; Oxidation-Reduction ; Oxidoreductases/genetics
Czasopismo naukowe
Tytuł :
The effects of FAR1 and TGFBRAP1 on the proliferation and apoptosis of follicular granulosa cells in goose (Anser cygnoides).
Autorzy :
Wang Z; Jiangsu Key Laboratory of Animal Genetics, Breeding and Molecular Design, Yangzhou University, Yangzhou 225009, China.
Lu L; Jiangsu Key Laboratory of Animal Genetics, Breeding and Molecular Design, Yangzhou University, Yangzhou 225009, China.
Gu T; Jiangsu Key Laboratory of Animal Genetics, Breeding and Molecular Design, Yangzhou University, Yangzhou 225009, China.
Hou L; Jiangsu Key Laboratory of Animal Genetics, Breeding and Molecular Design, Yangzhou University, Yangzhou 225009, China.
Du L; Jiangsu Key Laboratory of Animal Genetics, Breeding and Molecular Design, Yangzhou University, Yangzhou 225009, China.
Zhang Y; Jiangsu Key Laboratory of Animal Genetics, Breeding and Molecular Design, Yangzhou University, Yangzhou 225009, China.
Zhang Y; Jiangsu Key Laboratory of Animal Genetics, Breeding and Molecular Design, Yangzhou University, Yangzhou 225009, China.
Xu Q; Jiangsu Key Laboratory of Animal Genetics, Breeding and Molecular Design, Yangzhou University, Yangzhou 225009, China.
Chen G; Jiangsu Key Laboratory of Animal Genetics, Breeding and Molecular Design, Yangzhou University, Yangzhou 225009, China. Electronic address: .
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Źródło :
Gene [Gene] 2021 Feb 15; Vol. 769, pp. 145194. Date of Electronic Publication: 2020 Sep 30.
Typ publikacji :
Journal Article
MeSH Terms :
Aldehyde Oxidoreductases/*physiology
Geese/*physiology
Granulosa Cells/*physiology
Intracellular Signaling Peptides and Proteins/*physiology
Aldehyde Oxidoreductases/genetics ; Animals ; Apoptosis ; Cell Proliferation ; Female ; Geese/genetics ; Gene Knockout Techniques ; Intracellular Signaling Peptides and Proteins/genetics
Czasopismo naukowe
Tytuł :
Biosensor-Based Directed Evolution of Methanol Dehydrogenase from Lysinibacillus xylanilyticus .
Autorzy :
Le TK; School of Biological Sciences and Biotechnology, Graduate School, Chonnam National University, Yongbong-ro 77, Gwangju 61186, Korea.
Ju SB; School of Biological Sciences and Biotechnology, Graduate School, Chonnam National University, Yongbong-ro 77, Gwangju 61186, Korea.; School of Biological Sciences and Technology, Chonnam National University, Gwangju 61186, Korea.
Lee HW; Synthetic Biology and Bioengineering Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea.
Lee JY; Synthetic Biology and Bioengineering Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea.
Oh SH; Synthetic Biology and Bioengineering Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea.; Department of Biosystems and Bioengineering, KRIBB School of Biotechnology, University of Science & Technology, Daejeon 34113, Korea.
Kwon KK; Synthetic Biology and Bioengineering Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea.
Sung BH; Synthetic Biology and Bioengineering Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea.; Department of Biosystems and Bioengineering, KRIBB School of Biotechnology, University of Science & Technology, Daejeon 34113, Korea.
Lee SG; Synthetic Biology and Bioengineering Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea.; Department of Biosystems and Bioengineering, KRIBB School of Biotechnology, University of Science & Technology, Daejeon 34113, Korea.
Yeom SJ; School of Biological Sciences and Biotechnology, Graduate School, Chonnam National University, Yongbong-ro 77, Gwangju 61186, Korea.; School of Biological Sciences and Technology, Chonnam National University, Gwangju 61186, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 02; Vol. 22 (3). Date of Electronic Publication: 2021 Feb 02.
Typ publikacji :
Journal Article
MeSH Terms :
Mutation*
Alcohol Oxidoreductases/*genetics
Bacillaceae/*enzymology
Alcohol Oxidoreductases/metabolism ; Bacillaceae/genetics ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Biosensing Techniques ; Kinetics ; Methanol/metabolism
SCR Organism :
Lysinibacillus xylanilyticus
Czasopismo naukowe
Tytuł :
A rapid method to assess the formaldehyde dehydrogenase activity in plants for the remediation of formaldehyde.
Autorzy :
He X; College of Chemistry, Xinjiang University, Urumqi, 830046, Xinjiang, People's Republic of China.
Li D; College of Chemistry, Xinjiang University, Urumqi, 830046, Xinjiang, People's Republic of China.
Ablikim A; College of Chemistry, Xinjiang University, Urumqi, 830046, Xinjiang, People's Republic of China.
Yang Y; College of Chemistry, Xinjiang University, Urumqi, 830046, Xinjiang, People's Republic of China.
Su Y; College of Chemical Engineering, Xinjiang University, Urumqi, 830046, Xinjiang, People's Republic of China. .
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Źródło :
Environmental science and pollution research international [Environ Sci Pollut Res Int] 2021 Feb; Vol. 28 (7), pp. 8782-8790. Date of Electronic Publication: 2020 Oct 17.
Typ publikacji :
Journal Article
MeSH Terms :
Aldehyde Oxidoreductases*
Formaldehyde*
Oxidation-Reduction ; Plants
Czasopismo naukowe
Tytuł :
Response by Hayashida and Ichinose to Letter Regarding Article, "Improvement in Outcomes After Cardiac Arrest and Resuscitation by Inhibition of S-Nitrosoglutathione Reductase".
Autorzy :
Hayashida K; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Ichinose F; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
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Źródło :
Circulation [Circulation] 2019 Aug 06; Vol. 140 (6), pp. e192-e193. Date of Electronic Publication: 2019 Aug 05.
Typ publikacji :
Letter; Comment
MeSH Terms :
Heart Arrest*
Oxidoreductases*
Aldehyde Oxidoreductases ; Humans ; Resuscitation
Opinia redakcyjna
Tytuł :
Microbial cell surface display of oxidoreductases: Concepts and applications.
Autorzy :
Pham ML; Department of Chemical and Biochemical Engineering, Institute of Chemical and Environmental Engineering, Faculty of Chemical and Food Technology, Slovak University of Technology, Bratislava, Slovakia.
Polakovič M; Department of Chemical and Biochemical Engineering, Institute of Chemical and Environmental Engineering, Faculty of Chemical and Food Technology, Slovak University of Technology, Bratislava, Slovakia. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2020 Dec 15; Vol. 165 (Pt A), pp. 835-841. Date of Electronic Publication: 2020 Oct 02.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Bioelectric Energy Sources*
Biosensing Techniques*
Cell Surface Display Techniques*
Gram-Negative Bacteria*/genetics
Gram-Negative Bacteria*/metabolism
Gram-Positive Bacteria*/genetics
Gram-Positive Bacteria*/metabolism
Oxidoreductases*/biosynthesis
Oxidoreductases*/chemistry
Oxidoreductases*/genetics
Biodegradation, Environmental
Czasopismo naukowe

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