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Wyszukujesz frazę ""Occludin"" wg kryterium: Temat


Tytuł :
Tetrandrine attenuates intestinal epithelial barrier defects caused by colitis through promoting the expression of Occludin via the AhR-miR-429 pathway.
Autorzy :
Chu Y; Department of Pharmacology of Chinese Materia Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.
Zhu Y; Department of Pharmacology of Chinese Materia Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.
Zhang Y; Department of Pharmacology of Chinese Materia Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.
Liu X; Department of Pharmacology of Chinese Materia Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.
Guo Y; Department of Pharmacology of Chinese Materia Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.
Chang L; Department of Pharmacology of Chinese Materia Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.
Yun X; Department of Pharmacology of Chinese Materia Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.
Wei Z; Department of Pharmacology of Chinese Materia Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.
Xia Y; Department of Pharmacology of Chinese Materia Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.
Dai Y; Department of Pharmacology of Chinese Materia Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 May; Vol. 35 (5), pp. e21502.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Benzylisoquinolines/*pharmacology
Colitis/*complications
Intestinal Diseases/*drug therapy
Intestinal Mucosa/*drug effects
MicroRNAs/*genetics
Occludin/*metabolism
Receptors, Aryl Hydrocarbon/*metabolism
Animals ; Calcium Channel Blockers/pharmacology ; Colitis/chemically induced ; Colitis/pathology ; Dextran Sulfate/toxicity ; Female ; Gene Expression Regulation ; Humans ; Intestinal Diseases/etiology ; Intestinal Diseases/metabolism ; Intestinal Diseases/pathology ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Mice ; Mice, Inbred C57BL ; Occludin/genetics ; Permeability ; Receptors, Aryl Hydrocarbon/genetics
Czasopismo naukowe
Tytuł :
MiR-18a Aggravates Intracranial Hemorrhage by Regulating RUNX1-Occludin/ZO-1 Axis to Increase BBB Permeability.
Autorzy :
Ren S; Guizhou Medical University, Guiyang 550025, China; Department of Emergency, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China.
Wu G; Guizhou Medical University, Guiyang 550025, China; Department of Emergency, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China. Electronic address: .
Huang Y; Department of Emergency, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China.
Wang L; Department of Emergency, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China.
Li Y; Guizhou Medical University, Guiyang 550025, China.
Zhang Y; Guizhou Medical University, Guiyang 550025, China; Department of Emergency, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China.
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Źródło :
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association [J Stroke Cerebrovasc Dis] 2021 Aug; Vol. 30 (8), pp. 105878. Date of Electronic Publication: 2021 May 30.
Typ publikacji :
Journal Article
MeSH Terms :
Capillary Permeability*
Blood-Brain Barrier/*metabolism
Core Binding Factor Alpha 2 Subunit/*metabolism
Intracranial Hemorrhages/*metabolism
MicroRNAs/*metabolism
Occludin/*metabolism
Zonula Occludens-1 Protein/*metabolism
Animals ; Astrocytes/metabolism ; Astrocytes/pathology ; Blood-Brain Barrier/pathology ; Cells, Cultured ; Coculture Techniques ; Core Binding Factor Alpha 2 Subunit/genetics ; Disease Models, Animal ; Electric Impedance ; Endothelial Cells/metabolism ; Endothelial Cells/pathology ; Intracranial Hemorrhages/genetics ; Intracranial Hemorrhages/pathology ; Male ; MicroRNAs/genetics ; Occludin/genetics ; Rats, Sprague-Dawley ; Signal Transduction ; Zonula Occludens-1 Protein/genetics
Czasopismo naukowe
Tytuł :
Occludin-binding single-chain variable fragment and antigen-binding fragment antibodies prevent hepatitis C virus infection.
Autorzy :
Shimizu Y; Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, Shinjuku-ku, Japan.; Department of Pharmaceutical Sciences, Teikyo Heisei University, Nakano-ku, Japan.
Shinoda T; Laboratory for Protein Functional and Structural Biology, RIKEN Center for Biosystems Dynamics Research, Yokohama, Japan.
Shirasago Y; Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, Shinjuku-ku, Japan.
Kondoh M; Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.
Shinya N; Laboratory for Protein Functional and Structural Biology, RIKEN Center for Biosystems Dynamics Research, Yokohama, Japan.
Hanada K; Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, Shinjuku-ku, Japan.
Yagi K; Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.
Suzuki T; Department of Infectious Diseases, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Wakita T; Department of Virology II, National Institute of Infectious Diseases, Shinjuku-ku, Japan.
Kimura-Someya T; Laboratory for Protein Functional and Structural Biology, RIKEN Center for Biosystems Dynamics Research, Yokohama, Japan.
Shirouzu M; Laboratory for Protein Functional and Structural Biology, RIKEN Center for Biosystems Dynamics Research, Yokohama, Japan.
Fukasawa M; Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, Shinjuku-ku, Japan.
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Źródło :
FEBS letters [FEBS Lett] 2021 Jan; Vol. 595 (2), pp. 220-229. Date of Electronic Publication: 2020 Nov 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hepacivirus/*physiology
Hepatitis C/*metabolism
Immunoglobulin Fab Fragments/*pharmacology
Occludin/*metabolism
Single-Chain Antibodies/*pharmacology
Antibody Affinity ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Cell Line ; Hepacivirus/drug effects ; Hepatitis C/prevention & control ; Humans ; Immunoglobulin Fab Fragments/chemistry ; Models, Biological ; Occludin/chemistry ; Single-Chain Antibodies/chemistry ; Virus Internalization/drug effects ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
Lactobacillus casei LC01 Regulates Intestinal Epithelial Permeability through miR-144 Targeting of OCLN and ZO1.
Autorzy :
Hou Q; Department of Gastroenterology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510176, P.R. China.; School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.
Huang Y; Department of Orthopedics, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510176, P.R. China.
Wang Y; Department of Gastroenterology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510176, P.R. China.
Liao L; Department of Gastroenterology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510176, P.R. China.
Zhu Z; Department of Gastroenterology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510176, P.R. China.
Zhang W; Department of Gastroenterology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510176, P.R. China.
Liu Y; Department of Gastroenterology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510176, P.R. China.
Li P; Department of Gastroenterology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510176, P.R. China.
Chen X; Department of Preventive Medicine and Health Statistics, Guangzhou University of Chinese Medicine, Guangzhou 510176, Guangdong, P.R. China.
Liu F; Department of Gastroenterology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510176, P.R. China.
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Źródło :
Journal of microbiology and biotechnology [J Microbiol Biotechnol] 2020 Oct 28; Vol. 30 (10), pp. 1480-1487.
Typ publikacji :
Journal Article
MeSH Terms :
Lactobacillus casei/*metabolism
MicroRNAs/*genetics
Occludin/*genetics
Zonula Occludens-1 Protein/*genetics
Animals ; Cell Line ; Epithelial Cells/metabolism ; Gene Expression Regulation ; Humans ; Intestinal Mucosa/metabolism ; Intestines ; Irritable Bowel Syndrome/therapy ; MicroRNAs/antagonists & inhibitors ; MicroRNAs/metabolism ; Occludin/metabolism ; Permeability ; Rats ; Zonula Occludens-1 Protein/metabolism
Czasopismo naukowe
Tytuł :
Arsenite-induced downregulation of occludin in mouse lungs and BEAS-2B cells via the ROS/ERK/ELK1/MLCK and ROS/p38 MAPK signaling pathways.
Autorzy :
Liu Y; Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nantong University, Nantong, Jiangsu, 226019, China.
Tang J; Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nantong University, Nantong, Jiangsu, 226019, China.
Yuan J; Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nantong University, Nantong, Jiangsu, 226019, China.
Yao C; Department of Molecular Oral Physiology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima-Shi, Tokushima, 770-8504, Japan.
Hosoi K; Department of Molecular Oral Physiology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima-Shi, Tokushima, 770-8504, Japan; Kosei Pharmaceutical Co. Ltd., Osaka-shi, Osaka, 540-0039, Japan.
Han Y; Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nantong University, Nantong, Jiangsu, 226019, China.
Yu S; Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nantong University, Nantong, Jiangsu, 226019, China.
Wei H; Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nantong University, Nantong, Jiangsu, 226019, China. Electronic address: .
Chen G; Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nantong University, Nantong, Jiangsu, 226019, China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Oct 10; Vol. 332, pp. 146-154. Date of Electronic Publication: 2020 Jul 16.
Typ publikacji :
Journal Article
MeSH Terms :
Arsenites/*toxicity
Lung/*metabolism
Occludin/*biosynthesis
Signal Transduction/*drug effects
Animals ; Cell Line ; Down-Regulation/drug effects ; Glutathione/metabolism ; Humans ; Lung/drug effects ; MAP Kinase Signaling System/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Occludin/drug effects ; Oxidative Stress/drug effects ; Peptides/drug effects ; Peptides/metabolism ; Reactive Oxygen Species ; Superoxide Dismutase/metabolism ; p38 Mitogen-Activated Protein Kinases/drug effects
Czasopismo naukowe
Tytuł :
Lnc00462717 regulates the permeability of the blood-brain tumor barrier through interaction with PTBP1 to inhibit the miR-186-5p/Occludin signaling pathway.
Autorzy :
Zhang C; Department of Physiology, Life Science and Biopharmaceutical Institution, Shenyang Pharmaceutical University, Shenyang, P.R. China.
Zhang X; Department of Physiology, Life Science and Biopharmaceutical Institution, Shenyang Pharmaceutical University, Shenyang, P.R. China.
Wang J; Department of Physiology, Life Science and Biopharmaceutical Institution, Shenyang Pharmaceutical University, Shenyang, P.R. China.
Di F; Department of Neurosurgery, General Hospital of Northern Theater Command, Shenyang, P.R. China.
Xue Y; Department of Neurobiology, College Basic of Medicine, China Medical University, Shenyang, P.R. China.
Lin X; Graduate School of Jinzhou Medical University, Jinzhou, P.R. China.
Zhang Y; Department of Physiology, Life Science and Biopharmaceutical Institution, Shenyang Pharmaceutical University, Shenyang, P.R. China.
Zhang H; Department of Physiology, Life Science and Biopharmaceutical Institution, Shenyang Pharmaceutical University, Shenyang, P.R. China.
Zhang Z; Department of Physiology, Life Science and Biopharmaceutical Institution, Shenyang Pharmaceutical University, Shenyang, P.R. China.
Gu Y; Department of Physiology, Life Science and Biopharmaceutical Institution, Shenyang Pharmaceutical University, Shenyang, P.R. China.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2020 Aug; Vol. 34 (8), pp. 9941-9958. Date of Electronic Publication: 2020 Jul 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Blood-Brain Barrier/*metabolism
Doxorubicin/*pharmacology
Glioma/*pathology
Heterogeneous-Nuclear Ribonucleoproteins/*metabolism
MicroRNAs/*genetics
Occludin/*metabolism
Polypyrimidine Tract-Binding Protein/*metabolism
RNA, Long Noncoding/*genetics
Animals ; Antibiotics, Antineoplastic/pharmacology ; Apoptosis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Blood-Brain Barrier/drug effects ; Blood-Brain Barrier/pathology ; Brain Neoplasms/drug therapy ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Cell Membrane Permeability ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Glioma/drug therapy ; Glioma/metabolism ; Heterogeneous-Nuclear Ribonucleoproteins/genetics ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Occludin/genetics ; Polypyrimidine Tract-Binding Protein/genetics ; Rats, Wistar ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Piezo1 regulates intestinal epithelial function by affecting the tight junction protein claudin-1 via the ROCK pathway.
Autorzy :
Jiang Y; Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, Hubei Province 430022, China. Electronic address: .
Song J; Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, Hubei Province 430022, China.
Xu Y; Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, Hubei Province 430022, China.
Liu C; Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, Hubei Province 430022, China.
Qian W; Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, Hubei Province 430022, China.
Bai T; Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, Hubei Province 430022, China. Electronic address: .
Hou X; Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, Hubei Province 430022, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jun 15; Vol. 275, pp. 119254. Date of Electronic Publication: 2021 Feb 24.
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*/physiology
Claudin-1/*physiology
Intestinal Mucosa/*physiology
Ion Channels/*physiology
rho-Associated Kinases/*metabolism
Animals ; Blotting, Western ; Caco-2 Cells ; Claudin-1/metabolism ; Humans ; Intestinal Mucosa/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Occludin/metabolism ; Occludin/physiology ; Real-Time Polymerase Chain Reaction ; Zonula Occludens-1 Protein/metabolism ; Zonula Occludens-1 Protein/physiology
Czasopismo naukowe
Tytuł :
IL1B Increases Intestinal Tight Junction Permeability by Up-regulation of MIR200C-3p, Which Degrades Occludin mRNA.
Autorzy :
Rawat M; Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico.
Nighot M; Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania.
Al-Sadi R; Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania.
Gupta Y; Department of Medicine, Loyola University Medical Center, Maywood, Illinois.
Viszwapriya D; Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania.
Yochum G; Division of Colon and Rectal Surgery, Department of Surgery, Pennsylvania State University, College of Medicine, Hershey, Pennsylvania; Department of Biochemistry and Molecular Biology, Pennsylvania State University, College of Medicine, Hershey, Pennsylvania.
Koltun W; Division of Colon and Rectal Surgery, Department of Surgery, Pennsylvania State University, College of Medicine, Hershey, Pennsylvania.
Ma TY; Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico; Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania. Electronic address: .
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Źródło :
Gastroenterology [Gastroenterology] 2020 Oct; Vol. 159 (4), pp. 1375-1389. Date of Electronic Publication: 2020 Jun 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Colitis, Ulcerative/*pathology
Interleukin-1beta/*metabolism
MicroRNAs/*metabolism
Occludin/*metabolism
Tight Junctions/*metabolism
Animals ; Caco-2 Cells ; Cell Culture Techniques ; Colitis, Ulcerative/etiology ; Colitis, Ulcerative/metabolism ; Enterocytes ; Humans ; Intestinal Absorption/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Occludin/genetics ; Permeability ; RNA, Messenger/metabolism ; Up-Regulation
Czasopismo naukowe
Tytuł :
Small Interfering RNA Targeting DMP1 Protects Mice Against Blood-Brain Barrier Disruption and Brain Injury After Intracerebral Hemorrhage.
Autorzy :
Shu Y; Department of Anatomy, Basic Medical College, Chongqing Medical University, Chongqing 400016, China; Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China. Electronic address: .
Huang J; Department of Anatomy, Basic Medical College, Chongqing Medical University, Chongqing 400016, China; Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China. Electronic address: .
Gao M; Department of Clinical Laboratory, 521 Hospital of Ordnance Industry, Xi'an 7100065, China. Electronic address: .
Gan S; Department of Anatomy, Basic Medical College, Chongqing Medical University, Chongqing 400016, China; Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China. Electronic address: .
Zhu S; Department of Anatomy, Basic Medical College, Chongqing Medical University, Chongqing 400016, China; Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China. Electronic address: .
Xu S; Department of Anatomy, Basic Medical College, Chongqing Medical University, Chongqing 400016, China; Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China. Electronic address: .
Yang Z; Department of Anatomy, Basic Medical College, Chongqing Medical University, Chongqing 400016, China; Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China. Electronic address: .
Liao Y; Department of Anatomy, Basic Medical College, Chongqing Medical University, Chongqing 400016, China; Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China. Electronic address: .
Lu W; Department of Anatomy, Basic Medical College, Chongqing Medical University, Chongqing 400016, China; Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China. Electronic address: .
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Źródło :
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association [J Stroke Cerebrovasc Dis] 2021 Jun; Vol. 30 (6), pp. 105760. Date of Electronic Publication: 2021 Apr 09.
Typ publikacji :
Journal Article
MeSH Terms :
RNA Interference*
Blood-Brain Barrier/*metabolism
Brain Edema/*prevention & control
Cerebral Hemorrhage/*therapy
Extracellular Matrix Proteins/*metabolism
RNA, Small Interfering/*metabolism
Animals ; Blood-Brain Barrier/ultrastructure ; Brain Edema/genetics ; Brain Edema/metabolism ; Brain Edema/pathology ; Cerebral Hemorrhage/genetics ; Cerebral Hemorrhage/metabolism ; Cerebral Hemorrhage/pathology ; Disease Models, Animal ; Extracellular Matrix Proteins/genetics ; Male ; Matrix Metalloproteinase 9/genetics ; Matrix Metalloproteinase 9/metabolism ; Mice ; Occludin/genetics ; Occludin/metabolism ; RNA, Small Interfering/genetics ; Zonula Occludens-1 Protein/genetics ; Zonula Occludens-1 Protein/metabolism
Czasopismo naukowe
Tytuł :
The mRNA-binding protein IGF2BP1 maintains intestinal barrier function by up-regulating occludin expression.
Autorzy :
Singh V; Division of Hematology and Oncology, Pediatric Department, Pennsylvania State College of Medicine, Hershey, Pennsylvania, USA.
Gowda CP; Division of Hematology and Oncology, Pediatric Department, Pennsylvania State College of Medicine, Hershey, Pennsylvania, USA.
Singh V; Department of Nutritional Sciences, Pennsylvania State University, University Park, Pennsylvania, USA.
Ganapathy AS; Department of Medicine, Pennsylvania State College of Medicine, Hershey, Pennsylvania, USA.
Karamchandani DM; Department of Pathology, Pennsylvania State College of Medicine, Hershey, Pennsylvania, USA.
Eshelman MA; Department of Biochemistry & Molecular Biology, Pennsylvania State College of Medicine, Hershey, Pennsylvania, USA.
Yochum GS; Department of Biochemistry & Molecular Biology, Pennsylvania State College of Medicine, Hershey, Pennsylvania, USA.; Department of Surgery, Pennsylvania State College of Medicine, Hershey, Pennsylvania, USA.
Nighot P; Department of Medicine, Pennsylvania State College of Medicine, Hershey, Pennsylvania, USA.
Spiegelman VS; Division of Hematology and Oncology, Pediatric Department, Pennsylvania State College of Medicine, Hershey, Pennsylvania, USA .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Jun 19; Vol. 295 (25), pp. 8602-8612. Date of Electronic Publication: 2020 May 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Permeability*
Occludin/*metabolism
RNA-Binding Proteins/*metabolism
Animals ; Cell Line ; Colitis/chemically induced ; Colitis/mortality ; Colitis/pathology ; Colon/pathology ; Humans ; Intestinal Mucosa/cytology ; Intestinal Mucosa/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Occludin/genetics ; Protein Binding ; RNA Interference ; RNA, Messenger/metabolism ; RNA, Small Interfering/metabolism ; RNA-Binding Proteins/antagonists & inhibitors ; RNA-Binding Proteins/genetics ; Severity of Illness Index ; Survival Rate ; Tight Junction Proteins/metabolism ; Up-Regulation
Czasopismo naukowe
Tytuł :
High-fat diet exacerbates lead-induced blood-brain barrier disruption by disrupting tight junction integrity.
Autorzy :
Li C; School of Public Health, North China University of Science and Technology, Tangshan, Hebei, China.; Shandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, Shandong, China.
Shi L; Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, Shandong, China.
Wang Y; Institute of Plastic Surgery, Weifang Medical University, Weifang, Shandong, China.
Peng C; Shandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, Shandong, China.; Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, Brisbane, Queensland, Australia.
Wu L; School of Public Health, North China University of Science and Technology, Tangshan, Hebei, China.
Zhang Y; School of Public Health, North China University of Science and Technology, Tangshan, Hebei, China.; Laboratory Animal Center, North China University of Science and Technology, Tangshan, Hebei, China.
Du Z; Shandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, Shandong, China.
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Źródło :
Environmental toxicology [Environ Toxicol] 2021 Jul; Vol. 36 (7), pp. 1412-1421. Date of Electronic Publication: 2021 Mar 21.
Typ publikacji :
Journal Article
MeSH Terms :
Blood-Brain Barrier*/metabolism
Tight Junctions*/metabolism
Diet, High-Fat/adverse effects ; Humans ; Lead/toxicity ; Occludin/metabolism
Czasopismo naukowe
Tytuł :
Damage to the Blood Brain Barrier Structure and Function from Nano Titanium Dioxide Exposure Involves the Destruction of Key Tight Junction Proteins in the Mouse Brain.
Autorzy :
Hong F; Jiangsu Collaborative Innovation Center of Regional Modern Agriculture & Environmental Protection, Huaiyin Normal University, Huaian, 223300, China.
Mu X; Department of Biochemistry and Molecular Biology, School of Basic Medical and Biological Sciences, Soochow University, Suzhou, 215123, China.
Ze Y; Department of Biochemistry and Molecular Biology, School of Basic Medical and Biological Sciences, Soochow University, Suzhou, 215123, China.
Li W; Department of Biochemistry and Molecular Biology, School of Basic Medical and Biological Sciences, Soochow University, Suzhou, 215123, China.
Zhou Y; School of Life Sciences, Huaiyin Normal University, Huaian, 223300, China.
Ji J; Jiangsu Key Laboratory for Food Safety & Nutrition Function Evaluation, Huaiyin Normal University, Huaian, 223300, China.
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Źródło :
Journal of biomedical nanotechnology [J Biomed Nanotechnol] 2021 Jun 01; Vol. 17 (6), pp. 1068-1078.
Typ publikacji :
Journal Article
MeSH Terms :
Blood-Brain Barrier*/metabolism
Tight Junction Proteins*/metabolism
Animals ; Brain ; Claudin-5 ; Mice ; Occludin ; Tight Junctions/metabolism ; Titanium ; Zonula Occludens-1 Protein/metabolism
Czasopismo naukowe
Tytuł :
The magnitude of physical exercise-induced hyperthermia is associated with changes in the intestinal permeability and expression of tight junction genes in rats.
Autorzy :
Ribeiro Hudson AS; Exercise Physiology Laboratory, School of Physical Education, Physiotherapy and Occupational Therapy, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Nascimento Soares AD; Department of Clinical and Toxicological Analyses, Faculty of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Coelho Horta NA; Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Fuscaldi LL; Department of Clinical and Toxicological Analyses, Faculty of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Machado-Moreira CA; Exercise Physiology Laboratory, School of Physical Education, Physiotherapy and Occupational Therapy, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Soares DD; Exercise Physiology Laboratory, School of Physical Education, Physiotherapy and Occupational Therapy, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Coimbra CC; Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
de Oliveira Poletini M; Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Cardoso VN; Department of Clinical and Toxicological Analyses, Faculty of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Wanner SP; Exercise Physiology Laboratory, School of Physical Education, Physiotherapy and Occupational Therapy, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. Electronic address: .
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Źródło :
Journal of thermal biology [J Therm Biol] 2020 Jul; Vol. 91, pp. 102610. Date of Electronic Publication: 2020 May 18.
Typ publikacji :
Journal Article
MeSH Terms :
Physical Exertion*
Hyperthermia/*metabolism
Intestinal Mucosa/*metabolism
Occludin/*genetics
Zonula Occludens-1 Protein/*genetics
Animals ; Hyperthermia/etiology ; Intestinal Absorption ; Male ; Occludin/metabolism ; Rats ; Rats, Wistar ; Zonula Occludens-1 Protein/metabolism
Czasopismo naukowe
Tytuł :
Exploring Effects of Chitosan Oligosaccharides on the DSS-Induced Intestinal Barrier Impairment In Vitro and In Vivo.
Autorzy :
Wang Y; State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.; School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China.
Wen R; State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.; College of Life Science, Sichuan Normal University, Chengdu 610101, China.
Liu D; State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.
Zhang C; State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.
Wang ZA; State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.
Du Y; State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Apr 11; Vol. 26 (8). Date of Electronic Publication: 2021 Apr 11.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
Chitosan/*pharmacology
Colitis/*drug therapy
Intestinal Mucosa/*drug effects
Oligosaccharides/*pharmacology
Tight Junctions/*drug effects
Animals ; Body Weight/drug effects ; Caco-2 Cells ; Colitis/chemically induced ; Colitis/genetics ; Colitis/mortality ; Dextran Sulfate/administration & dosage ; Disease Models, Animal ; Gene Expression Regulation ; HT29 Cells ; Humans ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mucin-2/genetics ; Mucin-2/metabolism ; Occludin/genetics ; Occludin/metabolism ; Permeability/drug effects ; Signal Transduction ; Survival Analysis ; Tight Junctions/metabolism ; Tight Junctions/pathology
Czasopismo naukowe
Tytuł :
Immune-Mediated Aggravation of the Campylobacter concisus -Induced Epithelial Barrier Dysfunction.
Autorzy :
Nattramilarasu PK; Institute of Clinical Physiology/Nutritional Medicine, Medical Department, Division of Gastroenterology, Infectiology and Rheumatology, Charité-Universitätsmedizin Berlin, 12203 Berlin, Germany.
Lobo de Sá FD; Institute of Clinical Physiology/Nutritional Medicine, Medical Department, Division of Gastroenterology, Infectiology and Rheumatology, Charité-Universitätsmedizin Berlin, 12203 Berlin, Germany.
Schulzke JD; Institute of Clinical Physiology/Nutritional Medicine, Medical Department, Division of Gastroenterology, Infectiology and Rheumatology, Charité-Universitätsmedizin Berlin, 12203 Berlin, Germany.
Bücker R; Institute of Clinical Physiology/Nutritional Medicine, Medical Department, Division of Gastroenterology, Infectiology and Rheumatology, Charité-Universitätsmedizin Berlin, 12203 Berlin, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 19; Vol. 22 (4). Date of Electronic Publication: 2021 Feb 19.
Typ publikacji :
Journal Article
MeSH Terms :
Campylobacter/*immunology
Epithelial Cells/*immunology
Epithelial Cells/*microbiology
Apoptosis ; Cell Line ; Cell Survival ; Coculture Techniques ; Electric Impedance ; Epithelial Cells/pathology ; Humans ; Inflammation/pathology ; Intestines/microbiology ; Intestines/pathology ; Macrophages/metabolism ; Models, Biological ; Occludin/metabolism ; Subcellular Fractions/metabolism ; Tight Junctions/metabolism
SCR Organism :
Campylobacter concisus
Czasopismo naukowe
Tytuł :
Indole-3-propionic Acid Improved the Intestinal Barrier by Enhancing Epithelial Barrier and Mucus Barrier.
Autorzy :
Li J; State Key Laboratory of Food Science and Technology, Institute of Nutrition and School of Food Science, Nanchang University, Nanchang 330047, China.
Zhang L; State Key Laboratory of Food Science and Technology, Institute of Nutrition and School of Food Science, Nanchang University, Nanchang 330047, China.
Wu T; State Key Laboratory of Food Science and Technology, Institute of Nutrition and School of Food Science, Nanchang University, Nanchang 330047, China.
Li Y; University Campus Hospital and Jiangxi Academy of Medical Science, Nanchang University, Nanchang 330006, China.
Zhou X; School of Public Health, Jiangxi Province Key Laboratory of Preventive Medicine, Nanchang University, Nanchang 330006, China.
Ruan Z; State Key Laboratory of Food Science and Technology, Institute of Nutrition and School of Food Science, Nanchang University, Nanchang 330047, China.
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Źródło :
Journal of agricultural and food chemistry [J Agric Food Chem] 2021 Feb 10; Vol. 69 (5), pp. 1487-1495. Date of Electronic Publication: 2020 Dec 23.
Typ publikacji :
Journal Article
MeSH Terms :
Indoles/*pharmacology
Intestinal Mucosa/*drug effects
Tight Junctions/*drug effects
Caco-2 Cells ; Claudin-1/genetics ; Claudin-1/metabolism ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Humans ; Intestinal Mucosa/metabolism ; Occludin/genetics ; Occludin/metabolism ; Tight Junctions/genetics ; Tight Junctions/metabolism ; Zonula Occludens-1 Protein/genetics ; Zonula Occludens-1 Protein/metabolism
Czasopismo naukowe
Tytuł :
Lin 28A/Occludin axis: An aberrantly activated pathway in intestinal epithelial cells leading to impaired barrier function under total parenteral nutrition.
Autorzy :
Liu Y; Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Gong Z; Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai Institute for Pediatric Research, Shanghai, China.
Zhou J; Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai Institute for Pediatric Research, Shanghai, China.
Yan J; Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai Institute for Pediatric Research, Shanghai, China.
Cai W; Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai Institute for Pediatric Research, Shanghai, China.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Feb; Vol. 35 (2), pp. e21189. Date of Electronic Publication: 2020 Nov 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Enterocytes/*metabolism
Occludin/*metabolism
Parenteral Nutrition/*adverse effects
RNA-Binding Proteins/*metabolism
Tight Junctions/*metabolism
Animals ; Caco-2 Cells ; Cells, Cultured ; Enterocytes/pathology ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Rats ; Rats, Sprague-Dawley ; Signal Transduction ; Tight Junctions/pathology
Czasopismo naukowe
Tytuł :
Occludin degradation makes brain microvascular endothelial cells more vulnerable to reperfusion injury in vitro.
Autorzy :
Zhang Y; Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, The First Affiliated Hospital of Shenzhen University/Shenzhen Second People's Hospital, Graduate School of Guangzhou Medical University, Shenzhen, China.; Department of Pathophysiology, Baotou Medical College, Baotou, China.
Li X; Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, The First Affiliated Hospital of Shenzhen University/Shenzhen Second People's Hospital, Graduate School of Guangzhou Medical University, Shenzhen, China.
Qiao S; Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, The First Affiliated Hospital of Shenzhen University/Shenzhen Second People's Hospital, Graduate School of Guangzhou Medical University, Shenzhen, China.
Yang D; Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, The First Affiliated Hospital of Shenzhen University/Shenzhen Second People's Hospital, Graduate School of Guangzhou Medical University, Shenzhen, China.
Li Z; Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, The First Affiliated Hospital of Shenzhen University/Shenzhen Second People's Hospital, Graduate School of Guangzhou Medical University, Shenzhen, China.
Xu J; Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, The First Affiliated Hospital of Shenzhen University/Shenzhen Second People's Hospital, Graduate School of Guangzhou Medical University, Shenzhen, China.
Li W; Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, The First Affiliated Hospital of Shenzhen University/Shenzhen Second People's Hospital, Graduate School of Guangzhou Medical University, Shenzhen, China.
Su L; Department of Neurosurgery, Shenzhen University General Hospital, Shenzhen University, Shenzhen, China.
Liu W; Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, The First Affiliated Hospital of Shenzhen University/Shenzhen Second People's Hospital, Graduate School of Guangzhou Medical University, Shenzhen, China.
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Źródło :
Journal of neurochemistry [J Neurochem] 2021 Feb; Vol. 156 (3), pp. 352-366. Date of Electronic Publication: 2020 Jul 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Blood-Brain Barrier/*pathology
Endothelial Cells/*pathology
Occludin/*metabolism
Reperfusion Injury/*metabolism
Reperfusion Injury/*pathology
Animals ; Apoptosis/physiology ; Blood-Brain Barrier/metabolism ; Brain/metabolism ; Brain/pathology ; Cells, Cultured ; Cerebral Hemorrhage/metabolism ; Cerebral Hemorrhage/pathology ; Endothelial Cells/metabolism ; Ischemic Stroke/metabolism ; Ischemic Stroke/pathology ; Mice
Czasopismo naukowe
Tytuł :
Okra pectin relieves inflammatory response and protects damaged intestinal barrier in caerulein-induced acute pancreatic model.
Autorzy :
Xiong B; Engineering Research Center of Bio-Process of Ministry of Education, School of Food and Biological Engineering, Hefei University of Technology, Hefei, China.
Zhang W; Engineering Research Center of Bio-Process of Ministry of Education, School of Food and Biological Engineering, Hefei University of Technology, Hefei, China.
Wu Z; Engineering Research Center of Bio-Process of Ministry of Education, School of Food and Biological Engineering, Hefei University of Technology, Hefei, China.
Liu R; Engineering Research Center of Bio-Process of Ministry of Education, School of Food and Biological Engineering, Hefei University of Technology, Hefei, China.
Yang C; Engineering Research Center of Bio-Process of Ministry of Education, School of Food and Biological Engineering, Hefei University of Technology, Hefei, China.
Hui A
Huang X
Xian Z
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Źródło :
Journal of the science of food and agriculture [J Sci Food Agric] 2021 Feb; Vol. 101 (3), pp. 863-870. Date of Electronic Publication: 2020 Aug 27.
Typ publikacji :
Journal Article
MeSH Terms :
Abelmoschus/*chemistry
Ceruletide/*adverse effects
Intestinal Mucosa/*drug effects
Pancreatitis/*drug therapy
Pectins/*administration & dosage
Plant Extracts/*administration & dosage
Animals ; Cytokines/genetics ; Cytokines/immunology ; Fruit/chemistry ; Humans ; Intestinal Mucosa/immunology ; Male ; Mice ; Occludin/genetics ; Occludin/immunology ; Pancreatitis/chemically induced ; Pancreatitis/genetics ; Pancreatitis/immunology ; Pectins/chemistry ; Plant Extracts/chemistry ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/immunology ; Zonula Occludens-1 Protein/genetics ; Zonula Occludens-1 Protein/immunology
Czasopismo naukowe
Tytuł :
Occludin protects secretory cells from ER stress by facilitating SNARE-dependent apical protein exocytosis.
Autorzy :
Zhou T; School of Life Science and Technology, ShanghaiTech University, Shanghai, China 201210.; University of Chinese Academy of Sciences, Beijing, China 100049.
Lu Y; School of Life Science and Technology, ShanghaiTech University, Shanghai, China 201210.
Xu C; School of Life Science and Technology, ShanghaiTech University, Shanghai, China 201210.; University of Chinese Academy of Sciences, Beijing, China 100049.
Wang R; School of Life Science and Technology, ShanghaiTech University, Shanghai, China 201210.; University of Chinese Academy of Sciences, Beijing, China 100049.
Zhang L; School of Life Science and Technology, ShanghaiTech University, Shanghai, China 201210.
Lu P; School of Life Science and Technology, ShanghaiTech University, Shanghai, China 201210; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Mar 03; Vol. 117 (9), pp. 4758-4769. Date of Electronic Publication: 2020 Feb 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endoplasmic Reticulum Stress/*drug effects
Exocytosis/*physiology
Occludin/*pharmacology
Protective Agents/*pharmacology
SNARE Proteins/*metabolism
Animals ; Apoptosis ; Cell Differentiation ; Epithelium ; Female ; Homeostasis ; Lactation ; Mammary Glands, Animal/metabolism ; Mammary Glands, Animal/pathology ; Mice ; Mice, Knockout ; Milk/metabolism ; Morphogenesis ; Occludin/genetics ; Pregnancy ; Tight Junctions/metabolism ; Transcriptome
Czasopismo naukowe

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