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Tytuł :
Taurine exhibits an apoptosis-inducing effect on human nasopharyngeal carcinoma cells through PTEN/Akt pathways in vitro.
Autorzy :
He F; Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Japan.; Department of Otolaryngology Head and Neck Surgery, Mie University Graduate School of Medicine, Tsu, Japan.; Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Ma N; Graduate School of Health Science, Suzuka University of Medical Science, Suzuka, Japan.
Midorikawa K; Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Japan.
Hiraku Y; Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Japan.
Oikawa S; Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Japan.
Zhang Z; Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Huang G; Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Takeuchi K; Department of Otolaryngology Head and Neck Surgery, Mie University Graduate School of Medicine, Tsu, Japan. .
Murata M; Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Japan. .
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Źródło :
Amino acids [Amino Acids] 2018 Dec; Vol. 50 (12), pp. 1749-1758. Date of Electronic Publication: 2018 Sep 17.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Cell Proliferation/*drug effects
Nasopharyngeal Carcinoma/*metabolism
Nasopharyngeal Neoplasms/*metabolism
PTEN Phosphohydrolase/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Taurine/*pharmacology
Caspase 9/metabolism ; Cell Line, Tumor ; China ; Heat-Shock Proteins/metabolism ; Humans ; bcl-2-Associated X Protein/metabolism ; bcl-X Protein/metabolism
Czasopismo naukowe
Tytuł :
Melatonin induces apoptosis in cholangiocarcinoma cell lines by activating the reactive oxygen species-mediated mitochondrial pathway.
Autorzy :
Laothong U; Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Hiraku Y; Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Mie 514‑8507, Japan.
Oikawa S; Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Mie 514‑8507, Japan.
Intuyod K; Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Murata M; Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Mie 514‑8507, Japan.
Pinlaor S; Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
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Źródło :
Oncology reports [Oncol Rep] 2015 Mar; Vol. 33 (3), pp. 1443-9. Date of Electronic Publication: 2015 Jan 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antioxidants/*pharmacology
Apoptosis/*drug effects
Cholangiocarcinoma/*drug therapy
Melatonin/*pharmacology
Reactive Oxygen Species/*metabolism
8-Hydroxy-2'-Deoxyguanosine ; Bile Duct Neoplasms ; Bile Ducts, Intrahepatic ; Cell Line, Tumor ; Cell Survival ; Cholangiocarcinoma/pathology ; DNA Damage/drug effects ; DNA Damage/genetics ; Deoxyguanosine/analogs & derivatives ; Deoxyguanosine/biosynthesis ; Humans ; Mitochondria/metabolism ; Oxidative Stress/drug effects
Czasopismo naukowe
Tytuł :
Copper Oxide Nanoparticles Reduce Vasculogenesis in Transgenic Zebrafish Through Down-Regulation of Vascular Endothelial Growth Factor Expression and Induction of Apoptosis.
Autorzy :
Chang J
Ichihara G
Shimada Y
Tada-Oikawa S
Kuroyanagi J
Zhang B
Suzuki Y
Sehsah R
Kato M
Tanaka T
Ichihara S
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Źródło :
Journal of nanoscience and nanotechnology [J Nanosci Nanotechnol] 2015 Mar; Vol. 15 (3), pp. 2140-7.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Nanoparticles*
Zebrafish*
Apoptosis/*drug effects
Copper/*pharmacology
Down-Regulation/*drug effects
Neovascularization, Physiologic/*drug effects
Vascular Endothelial Growth Factor A/*genetics
Animals ; Animals, Genetically Modified ; Cell Survival/drug effects ; Copper/chemistry ; Human Umbilical Vein Endothelial Cells/cytology ; Human Umbilical Vein Endothelial Cells/drug effects ; Humans ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
Czasopismo naukowe
Tytuł :
Hepatocyte apoptosis in dairy cows with fatty infiltration of the liver.
Autorzy :
Tharwat M; Department of Animal Medicine, Faculty of Veterinary Medicine, Zagazig University, Egypt. />Endoh D
Oikawa S
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Źródło :
Research in veterinary science [Res Vet Sci] 2012 Dec; Vol. 93 (3), pp. 1281-6. Date of Electronic Publication: 2012 Apr 17.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*physiology
Cattle Diseases/*pathology
Fatty Liver/*veterinary
Hepatocytes/*cytology
Animals ; Cattle ; Comet Assay ; DNA Damage ; Dairying ; Fatty Liver/pathology ; Female ; Hepatocytes/physiology
Czasopismo naukowe
Tytuł :
Hepatocyte apoptosis in dairy cattle during the transition period.
Autorzy :
Tharwat M; Department of Large Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi, Ebetsu, Hokkaido 069-8501, Japan.
Takamizawa A
Hosaka YZ
Endoh D
Oikawa S
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Źródło :
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire [Can J Vet Res] 2012 Oct; Vol. 76 (4), pp. 241-7.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*physiology
Cattle/*metabolism
Hepatocytes/*cytology
Liver/*cytology
Animals ; Biopsy/veterinary ; Cattle/blood ; Comet Assay/veterinary ; DNA Damage ; Fatty Acids, Nonesterified/metabolism ; Female ; Hepatocytes/metabolism ; Hepatocytes/ultrastructure ; Immunohistochemistry/veterinary ; Liver/metabolism ; Liver/ultrastructure ; Microscopy, Electron, Transmission/veterinary ; Parturition ; Pregnancy ; Triglycerides/metabolism
Czasopismo naukowe
Tytuł :
Romidepsin (FK228), a potent histone deacetylase inhibitor, induces apoptosis through the generation of hydrogen peroxide.
Autorzy :
Mizutani H; College of Pharmacy, Kinjo Gakuin University, Nagoya, Japan.
Hiraku Y
Tada-Oikawa S
Murata M
Ikemura K
Iwamoto T
Kagawa Y
Okuda M
Kawanishi S
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Źródło :
Cancer science [Cancer Sci] 2010 Oct; Vol. 101 (10), pp. 2214-9. Date of Electronic Publication: 2010 Jul 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
Depsipeptides/*pharmacology
Histone Deacetylase Inhibitors/*pharmacology
Hydrogen Peroxide/*metabolism
Acetylcysteine/pharmacology ; Cell Line, Tumor ; Glutathione/metabolism ; Humans ; Hydroxamic Acids/pharmacology
Czasopismo naukowe
Tytuł :
[Preferential induction of apoptosis in regulatory T cells by tributyltin: possible involvement in the exacerbation of allergic diseases].
Autorzy :
Tada-Oikawa S; Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Mie, Japan. />Murata M
Kato T
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Źródło :
Nihon eiseigaku zasshi. Japanese journal of hygiene [Nihon Eiseigaku Zasshi] 2010 Sep; Vol. 65 (4), pp. 530-5.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
Environmental Pollutants/*adverse effects
Hypersensitivity/*etiology
T-Lymphocytes, Regulatory/*immunology
Th2 Cells/*immunology
Trialkyltin Compounds/*adverse effects
Animals ; Cell Differentiation/drug effects ; Cells, Cultured ; Clone Cells ; Female ; Glutathione/metabolism ; Humans ; Mice ; Mice, Inbred Strains ; Reactive Oxygen Species/metabolism ; T-Lymphocytes, Regulatory/metabolism ; Th2 Cells/cytology ; Th2 Cells/metabolism
Czasopismo naukowe
Tytuł :
The role of lysosomal rupture in neuronal death.
Autorzy :
Yamashima T; Department of Restorative Neurosurgery, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan. />Oikawa S
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Źródło :
Progress in neurobiology [Prog Neurobiol] 2009 Dec; Vol. 89 (4), pp. 343-58. Date of Electronic Publication: 2009 Sep 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Apoptosis/*physiology
Lysosomes/*physiology
Neurons/*physiology
Animals ; Calpain/metabolism ; Cathepsins/metabolism ; HSP72 Heat-Shock Proteins/metabolism ; Humans ; Ischemia/metabolism ; Models, Biological ; Oxidative Stress/physiology ; Up-Regulation/physiology
Czasopismo naukowe
Tytuł :
DNA damage and apoptosis induced by photosensitization of 5,10,15,20-tetrakis (N-methyl-4-pyridyl)-21H,23H-porphyrin via singlet oxygen generation.
Autorzy :
Tada-Oikawa S; Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
Oikawa S
Hirayama J
Hirakawa K
Kawanishi S
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Źródło :
Photochemistry and photobiology [Photochem Photobiol] 2009 Nov-Dec; Vol. 85 (6), pp. 1391-9.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*/drug effects
Apoptosis*/radiation effects
DNA Damage*/drug effects
DNA Damage*/radiation effects
Ultraviolet Rays*
Photosensitizing Agents/*pharmacology
Porphyrins/*pharmacology
Singlet Oxygen/*metabolism
Cell Line, Tumor ; Humans ; Molecular Structure ; Photosensitizing Agents/chemistry ; Porphyrins/chemistry
Czasopismo naukowe
Tytuł :
The mechanisms of oxidative DNA damage and apoptosis induced by norsalsolinol, an endogenous tetrahydroisoquinoline derivative associated with Parkinson's disease.
Autorzy :
Kobayashi H; Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Edobashi 2-174, Tsu, Mie, Japan.
Fukuhara K
Tada-Oikawa S
Yada Y
Hiraku Y
Murata M
Oikawa S
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Źródło :
Journal of neurochemistry [J Neurochem] 2009 Jan; Vol. 108 (2), pp. 397-407. Date of Electronic Publication: 2008 Dec 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
DNA Damage/*drug effects
Salsoline Alkaloids/*pharmacology
8-Hydroxy-2'-Deoxyguanosine ; Autoradiography ; Benzoquinones/metabolism ; Caspase 3/metabolism ; Cell Line, Tumor ; Copper/pharmacology ; Cytochromes c/metabolism ; Deoxyguanosine/analogs & derivatives ; Deoxyguanosine/metabolism ; Dose-Response Relationship, Drug ; Free Radical Scavengers/pharmacology ; Humans ; NAD/metabolism ; Neuroblastoma ; Phenanthrolines/pharmacology ; Phosphorus Isotopes/metabolism ; Tetrahydroisoquinolines/chemistry ; Tetrazolium Salts ; Thiazoles ; Time Factors ; Tyrosine 3-Monooxygenase/metabolism
Czasopismo naukowe
Tytuł :
Mechanism of metal-mediated DNA damage and apoptosis induced by 6-hydroxydopamine in neuroblastoma SH-SY5Y cells.
Autorzy :
Kobayashi H; Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
Oikawa S
Umemura S
Hirosawa I
Kawanishi S
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Źródło :
Free radical research [Free Radic Res] 2008 Jul; Vol. 42 (7), pp. 651-60.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Damage*
Apoptosis/*drug effects
Copper/*metabolism
Iron/*metabolism
Neuroblastoma/*pathology
Neurons/*drug effects
Oxidative Stress/*drug effects
Oxidopamine/*toxicity
8-Hydroxy-2'-Deoxyguanosine ; Benzoquinones/metabolism ; Biomarkers/metabolism ; Cell Line, Tumor ; Chelating Agents/pharmacology ; DNA Fragmentation ; Deoxyguanosine/analogs & derivatives ; Deoxyguanosine/metabolism ; Dose-Response Relationship, Drug ; Free Radical Scavengers/pharmacology ; Humans ; Hydrogen Peroxide/metabolism ; Iron Chelating Agents/pharmacology ; Neuroblastoma/genetics ; Neuroblastoma/metabolism ; Neurons/metabolism ; Neurons/pathology ; Oxidation-Reduction ; Time Factors
Czasopismo naukowe
Tytuł :
Critical role of hydrogen peroxide in the differential susceptibility of Th1 and Th2 cells to tributyltin-induced apoptosis.
Autorzy :
Tada-Oikawa S; Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Edobashi, Tsu, Mie 514-8507, Japan.
Kato T
Kuribayashi K
Nishino K
Murata M
Kawanishi S
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2008 Jan 15; Vol. 75 (2), pp. 552-61. Date of Electronic Publication: 2007 Sep 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
Hydrogen Peroxide/*toxicity
Th1 Cells/*drug effects
Th2 Cells/*drug effects
Trialkyltin Compounds/*toxicity
DNA Fragmentation/drug effects ; Glutathione/analysis ; HL-60 Cells ; Humans ; Hydrogen Peroxide/metabolism ; Membrane Potentials/drug effects
Czasopismo naukowe
Tytuł :
Mechanism of DNA damage and apoptosis induced by tetrahydropapaveroline, a metabolite of dopamine.
Autorzy :
Kobayashi H; Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Japan.
Oikawa S
Kawanishi S
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Źródło :
Neurochemical research [Neurochem Res] 2006 Apr; Vol. 31 (4), pp. 523-32. Date of Electronic Publication: 2006 May 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Damage*
Apoptosis/*physiology
Dopamine/*metabolism
Tetrahydropapaveroline/*toxicity
8-Hydroxy-2'-Deoxyguanosine ; Animals ; Calcium Channel Blockers/metabolism ; Cattle ; Copper/metabolism ; DNA Fragmentation ; Deoxyguanosine/analogs & derivatives ; Deoxyguanosine/metabolism ; Edetic Acid/metabolism ; Ferric Compounds/metabolism ; Free Radical Scavengers/metabolism ; HL-60 Cells ; Humans ; Ions ; Iron Chelating Agents/metabolism ; Metals/chemistry ; Molecular Structure ; Phenanthrolines/metabolism ; Piperidines/metabolism
Czasopismo naukowe
Tytuł :
Mechanism of apoptosis induced by doxorubicin through the generation of hydrogen peroxide.
Autorzy :
Mizutani H; Department of Environmental and Molecular Medicine, Mie University School of Medicine, Tsu, Mie 514-8507, Japan.
Tada-Oikawa S
Hiraku Y
Kojima M
Kawanishi S
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Źródło :
Life sciences [Life Sci] 2005 Feb 11; Vol. 76 (13), pp. 1439-53. Date of Electronic Publication: 2005 Jan 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibiotics, Antineoplastic/*pharmacology
Apoptosis/*drug effects
Deoxyguanosine/*analogs & derivatives
Doxorubicin/*pharmacology
Hydrogen Peroxide/*metabolism
8-Hydroxy-2'-Deoxyguanosine ; Aminoquinolines/pharmacology ; Anthracyclines/pharmacology ; Caspase 3 ; Caspases/metabolism ; Chromatography, High Pressure Liquid ; DNA/biosynthesis ; DNA/genetics ; DNA Damage/drug effects ; Deoxyguanosine/pharmacology ; Electrochemistry ; Enzyme Inhibitors/pharmacology ; Flow Cytometry ; HL-60 Cells ; Humans ; Indenes/pharmacology ; Membrane Potentials/drug effects ; NADPH Oxidases/antagonists & inhibitors ; Poly(ADP-ribose) Polymerase Inhibitors ; Topoisomerase I Inhibitors
Czasopismo naukowe
Tytuł :
Mechanism for generation of hydrogen peroxide and change of mitochondrial membrane potential during rotenone-induced apoptosis.
Autorzy :
Tada-Oikawa S; Department of Environmental and Molecular Medicine, Mie University School of Medicine, 2-174 Edobashi, -Tsu-shi, Mie, 514-8507, Japan.
Hiraku Y
Kawanishi M
Kawanishi S
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Źródło :
Life sciences [Life Sci] 2003 Nov 07; Vol. 73 (25), pp. 3277-88.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*physiology
Hydrogen Peroxide/*metabolism
Insecticides/*pharmacology
Mitochondria/*metabolism
Rotenone/*pharmacology
Apoptosis/drug effects ; DNA Damage ; DNA, Neoplasm/analysis ; Dose-Response Relationship, Drug ; Flow Cytometry ; HL-60 Cells ; Humans ; Intracellular Membranes/drug effects ; Intracellular Membranes/physiology ; Membrane Potentials/drug effects ; Mitochondria/drug effects ; NADH Dehydrogenase/antagonists & inhibitors ; NADH Dehydrogenase/metabolism ; NADPH Oxidases/biosynthesis ; Proto-Oncogene Proteins c-bcl-2/metabolism
Czasopismo naukowe
Tytuł :
Vacuolar H+-ATPase inhibitor induces apoptosis via lysosomal dysfunction in the human gastric cancer cell line MKN-1.
Autorzy :
Nakashima S; Third Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie, 514-8507.
Hiraku Y
Tada-Oikawa S
Hishita T
Gabazza EC
Tamaki S
Imoto I
Adachi Y
Kawanishi S
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Źródło :
Journal of biochemistry [J Biochem] 2003 Sep; Vol. 134 (3), pp. 359-64.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
Macrolides/*pharmacology
Caspase 3 ; Caspases/metabolism ; Cathepsin D/metabolism ; Cell Line, Tumor ; Enzyme Inhibitors/pharmacology ; Flow Cytometry ; Humans ; Hydrogen-Ion Concentration ; In Situ Nick-End Labeling ; Lysosomes/metabolism ; Proton-Translocating ATPases/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Epstein-Barr virus BHRF1 functions downstream of Bid cleavage and upstream of mitochondrial dysfunction to inhibit TRAIL-induced apoptosis in BJAB cells.
Autorzy :
Kawanishi M; Department of Microbiology, Graduate School of Medicine, Kyoto University, Kyoto 606-8315, Japan. />Tada-Oikawa S
Kawanishi S
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2002 Sep 27; Vol. 297 (3), pp. 682-7.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*physiology
Carrier Proteins/*metabolism
Herpesvirus 4, Human/*physiology
Membrane Glycoproteins/*physiology
Mitochondria/*physiology
Tumor Necrosis Factor-alpha/*physiology
Viral Proteins/*physiology
Apoptosis/drug effects ; Apoptosis Regulatory Proteins ; BH3 Interacting Domain Death Agonist Protein ; Base Sequence ; DNA Primers ; Genetic Vectors ; Humans ; Kinetics ; Lymphoma, B-Cell ; Membrane Potentials/physiology ; Recombinant Proteins/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; TNF-Related Apoptosis-Inducing Ligand ; Tumor Cells, Cultured ; Viral Proteins/genetics
Czasopismo naukowe
Tytuł :
Mechanism of apoptosis induced by a new topoisomerase inhibitor through the generation of hydrogen peroxide.
Autorzy :
Mizutani H; Department of Environmental and Molecular Medicine, Mie University School of Medicine, Edobashi, Tsu, Mie 514-8507, Japan.
Tada-Oikawa S
Hiraku Y
Oikawa S
Kojima M
Kawanishi S
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2002 Aug 23; Vol. 277 (34), pp. 30684-9. Date of Electronic Publication: 2002 Jun 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Topoisomerase I Inhibitors*
Aminoquinolines/*pharmacology
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Enzyme Inhibitors/*pharmacology
Hydrogen Peroxide/*metabolism
Indenes/*pharmacology
DNA Damage ; HL-60 Cells ; Humans ; NADPH Oxidases/antagonists & inhibitors ; NADPH Oxidases/physiology ; Poly(ADP-ribose) Polymerase Inhibitors ; Poly(ADP-ribose) Polymerases/physiology ; Proto-Oncogene Proteins c-bcl-2/physiology
Czasopismo naukowe
Tytuł :
Distamycin A, a minor groove binder, changes enediyne-induced DNA cleavage sites and enhances apoptosis.
Autorzy :
Hiraku Y; Department of Environmental and Molecular Medicine, Mie University School of Medicine, Tsu, Mie, 514-8507, Japan.
Oikawa S
Kawanishi S
Pokaż więcej
Źródło :
Nucleic acids research. Supplement (2001) [Nucleic Acids Res Suppl] 2002 (2), pp. 95-6.
Typ publikacji :
Journal Article
MeSH Terms :
Aminoglycosides*
Anti-Bacterial Agents/*pharmacology
Apoptosis/*drug effects
DNA/*metabolism
Distamycins/*pharmacology
Base Sequence ; Binding Sites ; Distamycins/metabolism ; Enediynes ; Molecular Sequence Data
Czasopismo naukowe

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