Genomic Characterization and Therapeutic Targeting of HPV Undetected Cervical Carcinomas.
Autorzy:
Ruiz FJ; Division of Biological and Biomedical Sciences Molecular Cell Biology, Washington University School of Medicine, St. Louis, MO 63108, USA.; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63108, USA. Sundaresan A; Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Zhang J; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63108, USA.; Institute for Informatics, Washington University School of Medicine, St. Louis, MO 63108, USA.; Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63108, USA. Pedamallu CS; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Halle MK; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.; Department of Obstetrics and Gynaecology, Haukeland University Hospital, 5021 Bergen, Norway.; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, 5020 Bergen, Norway. Srinivasasainagendra V; Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Zhang J; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Muhammad N; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63108, USA. Stanley J; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63108, USA.; Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63108, USA. Markovina S; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63108, USA.; Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63108, USA. Tiwari HK; Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Grigsby PW; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63108, USA.; Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63108, USA. Krakstad C; Department of Obstetrics and Gynaecology, Haukeland University Hospital, 5021 Bergen, Norway.; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, 5020 Bergen, Norway. Schwarz JK; Division of Biological and Biomedical Sciences Molecular Cell Biology, Washington University School of Medicine, St. Louis, MO 63108, USA.; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63108, USA.; Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63108, USA.; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63108, USA. OjesinaAI; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.; HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA.
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Źródło:
Cancers [Cancers (Basel)] 2021 Sep 10; Vol. 13 (18). Date of Electronic Publication: 2021 Sep 10.
Immunophenotype-associated gene signature in ductal breast tumors varies by receptor subtype, but the expression of individual signature genes remains consistent.
Autorzy:
Behring M; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.; Department of Pathology and Surgery, University of Alabama at Birmingham, Birmingham, AL, USA. Ye Y; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA. Elkholy A; Department of Pathology and Surgery, University of Alabama at Birmingham, Birmingham, AL, USA. Bajpai P; Department of Pathology and Surgery, University of Alabama at Birmingham, Birmingham, AL, USA. Agarwal S; Department of Pathology and Surgery, University of Alabama at Birmingham, Birmingham, AL, USA. Kim HG; Department of Pathology and Surgery, University of Alabama at Birmingham, Birmingham, AL, USA. OjesinaAI; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.; Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA. Wiener HW; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA. Manne U; Department of Pathology and Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.; Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA. Shrestha S; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA. Vazquez AI; Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, USA.; Institute for Quantitative Health Science & Engineering, East Lansing, MI, USA.
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Źródło:
Cancer medicine [Cancer Med] 2021 Aug; Vol. 10 (16), pp. 5712-5720. Date of Electronic Publication: 2021 Jun 29.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
Dissection of PIK3CA Aberration for Cervical Adenocarcinoma Outcomes.
Autorzy:
Chung TKH; The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong. Doran G; Firefly Bioworks, Inc., Cambridge, MA 02139, USA. Cheung TH; The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong. Yim SF; The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong. Yu MY; The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong. Worley MJ Jr; Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA. Elias KM; Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA. Thorner AR; Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA 02115, USA. Pedamallu CS; Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. OjesinaAI; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Lau KM; The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong. Ducar MD; Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA 02115, USA. Wong RRY; The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong. Wang VW; Mayo Clinic, Rochester, MN 55902, USA. Nag A; Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA 02115, USA. Wollison BM; Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA 02115, USA. Dalgarno A; Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA 02115, USA. Lee JHS; The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong. Yeung SY; The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong. Wong L; The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong. Horowitz NS; Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA. Davis MR; Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA. Leung SA; Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA. Mu Y; Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA. Mok SC; MD Anderson Cancer Center, The University of Texas, Houston, TX 77030, USA. Chan PKS; The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong. Lawrence MS; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA. Crum CP; Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA. Chiu RWK; The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong. Berkowitz RS; Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA. Wong YF; The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.; Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA.
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Źródło:
Cancers [Cancers (Basel)] 2021 Jun 28; Vol. 13 (13). Date of Electronic Publication: 2021 Jun 28.
HPV-EM: an accurate HPV detection and genotyping EM algorithm.
Autorzy:
Inkman MJ; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, 63108, USA. Jayachandran K; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, 63108, USA. Ellis TM; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, 63108, USA.; Department of Computer Science, Washington University in St. Louis, St. Louis, MO, 63105, USA. Ruiz F; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, 63108, USA. McLellan MD; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, 63108, USA. Miller CA; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, 63108, USA. Wu Y; Computer Science and Engineering Department, University of Connecticut, Storrs, CT, 06269, USA. OjesinaAI; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.; Hudson-Alpha Institute for Biotechnology, Huntsville, AL, 35806, USA. Schwarz JK; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, 63108, USA.; Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, 63108, USA.; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, 63108, USA. Zhang J; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, 63108, USA. .; Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, 63108, USA. .; Institute for Informatics, Washington University School of Medicine, St. Louis, MO, 63108, USA. .
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Źródło:
Scientific reports [Sci Rep] 2020 Aug 31; Vol. 10 (1), pp. 14340. Date of Electronic Publication: 2020 Aug 31.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Gain of function in somatic TP53 mutations is associated with immune-rich breast tumors and changes in tumor-associated macrophages.
Autorzy:
Behring M; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.; Department of Pathology and Surgery, University of Alabama at Birmingham, Birmingham, AL, USA. Vazquez AI; Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA.; Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, USA. Cui X; Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA, USA. Irvin MR; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA. OjesinaAI; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.; HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.; Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA. Agarwal S; Department of Pathology and Surgery, University of Alabama at Birmingham, Birmingham, AL, USA. Manne U; Department of Pathology and Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.; Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA. Shrestha S; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.; Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA.
Landscape of genomic alterations in cervical carcinomas.
Autorzy:
OjesinaAI; 1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA [2] The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA [3]. Lichtenstein L; 1] The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA [2]. Freeman SS; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA. Pedamallu CS; 1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA [2] The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA. Imaz-Rosshandler I; Instituto Nacional de Medicina Genomica, Mexico City 14610, Mexico. Pugh TJ; 1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA [2] The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA. Cherniack AD; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA. Ambrogio L; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA. Cibulskis K; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA. Bertelsen B; Department of Pathology, Haukeland University Hospital, N5021 Bergen, Norway. Romero-Cordoba S; Instituto Nacional de Medicina Genomica, Mexico City 14610, Mexico. Treviño V; Tecnológico de Monterrey, Monterrey 64849, Mexico. Vazquez-Santillan K; Instituto Nacional de Medicina Genomica, Mexico City 14610, Mexico. Guadarrama AS; Instituto Nacional de Medicina Genomica, Mexico City 14610, Mexico. Wright AA; 1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA [2] Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. Rosenberg MW; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA. Duke F; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA. Kaplan B; 1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA [2] The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA. Wang R; 1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA [2] Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China. Nickerson E; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA. Walline HM; Cancer Biology Program, Program in the Biomedical Sciences, Rackham Graduate School, University of Michigan, Ann Arbor, Michigan 48109, USA. Lawrence MS; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA. Stewart C; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA. Carter SL; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA. McKenna A; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA. Rodriguez-Sanchez IP; Facultad de Medicina y Hospital Universitario 'Dr. José Eluterio González' de la Universidad Autónoma de Nuevo León, Monterrey, Nuevo León 64460, México. Espinosa-Castilla M; Instituto Nacional de Medicina Genomica, Mexico City 14610, Mexico. Woie K; Department of Obstetrics and Gynecology, Haukeland University Hospital, N5021 Bergen, Norway. Bjorge L; 1] Department of Obstetrics and Gynecology, Haukeland University Hospital, N5021 Bergen, Norway [2] Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, N5020 Bergen, Norway. Wik E; 1] Department of Obstetrics and Gynecology, Haukeland University Hospital, N5021 Bergen, Norway [2] Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, N5020 Bergen, Norway. Halle MK; 1] Department of Obstetrics and Gynecology, Haukeland University Hospital, N5021 Bergen, Norway [2] Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, N5020 Bergen, Norway. Hoivik EA; 1] Department of Obstetrics and Gynecology, Haukeland University Hospital, N5021 Bergen, Norway [2] Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, N5020 Bergen, Norway. Krakstad C; 1] Department of Obstetrics and Gynecology, Haukeland University Hospital, N5021 Bergen, Norway [2] Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, N5020 Bergen, Norway. Gabiño NB; Instituto Nacional de Medicina Genomica, Mexico City 14610, Mexico. Gómez-Macías GS; Facultad de Medicina y Hospital Universitario 'Dr. José Eluterio González' de la Universidad Autónoma de Nuevo León, Monterrey, Nuevo León 64460, México. Valdez-Chapa LD; Facultad de Medicina y Hospital Universitario 'Dr. José Eluterio González' de la Universidad Autónoma de Nuevo León, Monterrey, Nuevo León 64460, México. Garza-Rodríguez ML; Facultad de Medicina y Hospital Universitario 'Dr. José Eluterio González' de la Universidad Autónoma de Nuevo León, Monterrey, Nuevo León 64460, México. Maytorena G; Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico. Vazquez J; Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico. Rodea C; Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico. Cravioto A; Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico. Cortes ML; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA. Greulich H; 1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA [2] The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA [3] Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. Crum CP; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. Neuberg DS; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA. Hidalgo-Miranda A; Instituto Nacional de Medicina Genomica, Mexico City 14610, Mexico. Escareno CR; 1] Instituto Nacional de Medicina Genomica, Mexico City 14610, Mexico [2] Claremont Graduate University, Claremont, California 91711, USA. Akslen LA; 1] Department of Pathology, Haukeland University Hospital, N5021 Bergen, Norway [2] Centre for Cancer Biomarkers, Department of Clinical Medicine, University of Bergen, N5020 Bergen, Norway. Carey TE; Head and Neck Oncology Program and Department of Otolaryngology, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 38109, USA. Vintermyr OK; 1] Department of Pathology, Haukeland University Hospital, N5021 Bergen, Norway [2] Centre for Cancer Biomarkers, Department of Clinical Medicine, University of Bergen, N5020 Bergen, Norway. Gabriel SB; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA. Barrera-Saldaña HA; Facultad de Medicina y Hospital Universitario 'Dr. José Eluterio González' de la Universidad Autónoma de Nuevo León, Monterrey, Nuevo León 64460, México. Melendez-Zajgla J; Instituto Nacional de Medicina Genomica, Mexico City 14610, Mexico. Getz G; 1] The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA [2] Massachusetts General Hospital Cancer Center and Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA. Salvesen HB; 1] Department of Obstetrics and Gynecology, Haukeland University Hospital, N5021 Bergen, Norway [2] Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, N5020 Bergen, Norway [3]. Meyerson M; 1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA [2] The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA [3] Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA [4].
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Źródło:
Nature [Nature] 2014 Feb 20; Vol. 506 (7488), pp. 371-5. Date of Electronic Publication: 2013 Dec 25.
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