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Tytuł :
Effects of prolonged cold-ischemia on autophagy in the graft lung in a rat orthotopic lung transplantation model.
Autorzy :
Lin HQ; Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, PR China.
Dai SH; Department of Thoracic Surgery, the First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China.
Liu WC; Department of Anesthesiology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China.
Lin X; Department of Thoracic Surgery, the First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China.
Yu BT; Department of Thoracic Surgery, the First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China.
Chen SB; Department of Anesthesiology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China.
Liu S; Department of Thoracic Surgery, the First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China.
Ling H; Department of Nursing, the First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China. Electronic address: .
Tang J; Department of Thoracic Surgery, the First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Mar 01; Vol. 268, pp. 118820. Date of Electronic Publication: 2020 Dec 02.
Typ publikacji :
Journal Article
MeSH Terms :
Autophagy/*physiology
Cold Ischemia/*adverse effects
Lung/*pathology
Lung Transplantation/*methods
Adenine/analogs & derivatives ; Adenine/pharmacology ; Animals ; Cold Ischemia/methods ; Glycolysis ; Lung/drug effects ; Lung/metabolism ; Lung Transplantation/adverse effects ; Lysosome-Associated Membrane Glycoproteins/metabolism ; Male ; Mitochondria/pathology ; Oligomycins/pharmacology ; Organ Preservation/adverse effects ; Organ Preservation/methods ; Oxidative Phosphorylation ; Perfusion ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism ; Reperfusion Injury/etiology ; Reperfusion Injury/pathology ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł :
Oligomycin A promotes radioresistance in HT29 colorectal cancer cells and its mechanisms.
Autorzy :
Li X; Department of Oncology, Third Xiangya Hospital, Central South University, Changsha 410013, China. .
Tian R; Department of Oncology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Wang L; Department of Oncology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Xu C; Department of Oncology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Wu H; Department of Oncology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Liu L; Department of Oncology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Huang C; Department of Oncology, Third Xiangya Hospital, Central South University, Changsha 410013, China. .
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Transliterated Title :
寡霉素A增加结直肠癌HT29细胞放射治疗抵抗及其机制.
Źródło :
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences [Zhong Nan Da Xue Xue Bao Yi Xue Ban] 2021 Feb 28; Vol. 46 (2), pp. 113-120.
Typ publikacji :
Journal Article
MeSH Terms :
Colorectal Neoplasms*/genetics
Cell Line, Tumor ; HT29 Cells ; Humans ; Oligomycins/pharmacology ; Radiation Tolerance
Czasopismo naukowe
Tytuł :
Synthesis, antimicrobial and antiproliferative properties of epi-oligomycin A, the (33 S )-diastereomer of oligomycin A.
Autorzy :
Lysenkova LN; Gause Institute of New Antibiotics, Moscow, 119021, Russian Federation.
Saveljev OY; Lomonosov Moscow State University, Moscow, 119991, Russian Federation.
Omelchuk OA; Gause Institute of New Antibiotics, Moscow, 119021, Russian Federation.; Mendeleev University of Chemical Technology, Moscow, Russian Federation.
Zatonsky GV; Gause Institute of New Antibiotics, Moscow, 119021, Russian Federation.
Korolev AM; Gause Institute of New Antibiotics, Moscow, 119021, Russian Federation.
Grammatikova NE; Gause Institute of New Antibiotics, Moscow, 119021, Russian Federation.
Bekker OB; Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russian Federation.
Danilenko VN; Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russian Federation.
Dezhenkova LG; Gause Institute of New Antibiotics, Moscow, 119021, Russian Federation.
Mavletova DA; Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russian Federation.
Scherbakov AM; Blokhin National Medical Research Center of Oncology, Moscow, Russian Federation.
Shchekotikhin AE; Gause Institute of New Antibiotics, Moscow, 119021, Russian Federation.; Mendeleev University of Chemical Technology, Moscow, Russian Federation.
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Źródło :
Natural product research [Nat Prod Res] 2020 Nov; Vol. 34 (21), pp. 3073-3081. Date of Electronic Publication: 2019 May 10.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Bacterial Agents/*pharmacology
Oligomycins/*chemical synthesis
Oligomycins/*pharmacology
Animals ; Anti-Bacterial Agents/chemistry ; Antibiotics, Antineoplastic/chemistry ; Antibiotics, Antineoplastic/pharmacology ; Aspergillus niger/drug effects ; Candida/drug effects ; Cell Proliferation/drug effects ; Dogs ; Drug Resistance, Neoplasm ; Humans ; K562 Cells ; MCF-7 Cells ; Madin Darby Canine Kidney Cells ; Magnetic Resonance Spectroscopy ; Mass Spectrometry ; Microbial Sensitivity Tests ; Stereoisomerism ; Streptomyces/drug effects ; Structure-Activity Relationship
SCR Organism :
Streptomyces fradiae
Czasopismo naukowe
Tytuł :
Caspase inhibition rescues F1Fo ATP synthase dysfunction-mediated dendritic spine elimination.
Autorzy :
Chen H; Department of Biological Sciences, The University of Texas at Dallas, 800 west Campbell Rd, Richardson, TX, 75080, USA.
Tian J; Department of Biological Sciences, The University of Texas at Dallas, 800 west Campbell Rd, Richardson, TX, 75080, USA.
Guo L; Department of Biological Sciences, The University of Texas at Dallas, 800 west Campbell Rd, Richardson, TX, 75080, USA.; Higuchi Biosciences Center, The University of Kansas, Lawrence, KS, 66045, USA.
Du H; Department of Biological Sciences, The University of Texas at Dallas, 800 west Campbell Rd, Richardson, TX, 75080, USA. .; Higuchi Biosciences Center, The University of Kansas, Lawrence, KS, 66045, USA. .; Department of Pharmacology & Toxicology, The University of Kansas, Lawrence, KS, 66045, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 Oct 16; Vol. 10 (1), pp. 17589. Date of Electronic Publication: 2020 Oct 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Dendritic Spines/*metabolism
Mitochondria/*metabolism
Mitochondrial Proton-Translocating ATPases/*metabolism
Adenosine Triphosphate/metabolism ; Amino Acid Chloromethyl Ketones/pharmacology ; Animals ; Caspase 3/metabolism ; Caspase Inhibitors/pharmacology ; Cell Death ; Female ; Hippocampus/metabolism ; Male ; Membrane Potential, Mitochondrial ; Mice ; Mice, Inbred C57BL ; Mitochondrial Proton-Translocating ATPases/physiology ; Neurons/metabolism ; Oligomycins/metabolism ; Oligomycins/pharmacology ; Quinolines/pharmacology ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
Homo-Tris-Nitrones Derived from α-Phenyl- N-tert -butylnitrone: Synthesis, Neuroprotection and Antioxidant Properties.
Autorzy :
Diez-Iriepa D; Laboratory of Medicinal Chemistry, Institute of Organic Chemistry (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain.; Department of Organic Chemistry and Inorganic Chemistry, Alcalá University, Alcalá de Henares, 28805 Madrid, Spain.
Chamorro B; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University of Madrid, Plaza Ramón y Cajal s/n, Ciudad Universitaria, 28040 Madrid, Spain.; Faculty of Health, Camilo José Cela University of Madrid (UCJC), 28692 Villafranca del Castillo, Spain.
Talaván M; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University of Madrid, Plaza Ramón y Cajal s/n, Ciudad Universitaria, 28040 Madrid, Spain.
Chioua M; Laboratory of Medicinal Chemistry, Institute of Organic Chemistry (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain.
Iriepa I; Department of Organic Chemistry and Inorganic Chemistry, Alcalá University, Alcalá de Henares, 28805 Madrid, Spain.; Institute of Chemical Research Andrés M. del Río, Alcalá University, Alcalá de Henares, 28805 Madrid, Spain.
Hadjipavlou-Litina D; Department of Pharmaceutical Chemistry, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
López-Muñoz F; Faculty of Health, Camilo José Cela University of Madrid (UCJC), 28692 Villafranca del Castillo, Spain.; Neuropsychopharmacology Unit, 'Hospital 12 de Octubre' Research Institute, 28041 Madrid, Spain.
Marco-Contelles J; Laboratory of Medicinal Chemistry, Institute of Organic Chemistry (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain.
Oset-Gasque MJ; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University of Madrid, Plaza Ramón y Cajal s/n, Ciudad Universitaria, 28040 Madrid, Spain.; Instituto Universitario de Investigación en Neuroquímica, Universidad Complutense de Madrid, 28040 Madrid, Spain.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Oct 26; Vol. 21 (21). Date of Electronic Publication: 2020 Oct 26.
Typ publikacji :
Journal Article
MeSH Terms :
Antioxidants/*chemical synthesis
Cyclic N-Oxides/*chemistry
Neurons/*cytology
Neuroprotective Agents/*chemical synthesis
Nitrogen Oxides/*chemical synthesis
Antioxidants/chemistry ; Antioxidants/pharmacology ; Caspase 3/metabolism ; Cell Line ; Cell Survival/drug effects ; Humans ; Molecular Structure ; Neurons/drug effects ; Neurons/metabolism ; Neuroprotective Agents/chemistry ; Neuroprotective Agents/pharmacology ; Nitrogen Oxides/chemistry ; Nitrogen Oxides/pharmacology ; Oligomycins/adverse effects ; Reactive Oxygen Species/metabolism ; Rotenone/adverse effects
Czasopismo naukowe
Tytuł :
Oligomycin-induced proton uncoupling.
Autorzy :
Hearne A; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA. Electronic address: .
Chen H; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA. Electronic address: .
Monarchino A; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA. Electronic address: .
Wiseman JS; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA. Electronic address: .
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Źródło :
Toxicology in vitro : an international journal published in association with BIBRA [Toxicol In Vitro] 2020 Sep; Vol. 67, pp. 104907. Date of Electronic Publication: 2020 Jun 02.
Typ publikacji :
Journal Article
MeSH Terms :
Protons*
Mitochondria/*drug effects
Oligomycins/*toxicity
Uncoupling Agents/*toxicity
Adenosine Triphosphate/metabolism ; Cell Line ; Humans ; L-Lactate Dehydrogenase/metabolism ; Mitochondria/physiology ; Oxygen/metabolism
Czasopismo naukowe
Tytuł :
Synthesis, antioxidant properties and neuroprotection of α-phenyl-tert-butylnitrone derived HomoBisNitrones in in vitro and in vivo ischemia models.
Autorzy :
Chamorro B; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University of Madrid, 28040, Madrid, Spain.; Faculty of Health, Camilo José Cela University of Madrid (UCJC), Madrid, Spain.
Diez-Iriepa D; Laboratory of Medicinal Chemistry, Institute of Organic Chemistry (CSIC), Juan de la Cierva 3, 28006, Madrid, Spain.; Department of Organic Chemistry and Inorganic Chemistry, Alcalá University, 28805, Alcalá de Henares, Madrid, Spain.
Merás-Sáiz B; Laboratory of Medicinal Chemistry, Institute of Organic Chemistry (CSIC), Juan de la Cierva 3, 28006, Madrid, Spain.
Chioua M; Laboratory of Medicinal Chemistry, Institute of Organic Chemistry (CSIC), Juan de la Cierva 3, 28006, Madrid, Spain.
García-Vieira D; Laboratory of Medicinal Chemistry, Institute of Organic Chemistry (CSIC), Juan de la Cierva 3, 28006, Madrid, Spain.
Iriepa I; Department of Organic Chemistry and Inorganic Chemistry, Alcalá University, 28805, Alcalá de Henares, Madrid, Spain.; Institute of Chemical Research Andrés M. del Río, Alcalá University, 28805, Alcalá de Henares, Madrid, Spain.
Hadjipavlou-Litina D; Department of Pharmaceutical Chemistry, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece.
López-Muñoz F; Faculty of Health, Camilo José Cela University of Madrid (UCJC), Madrid, Spain.; Neuropsychopharmacology Unit, 'Hospital 12 de Octubre' Research Institute, Madrid, Spain.
Martínez-Murillo R; Neurovascular Research Group, Department of Translational Neurobiology, Cajal Institute (CSIC), Madrid, Spain. .
Gonzàlez-Nieto D; Center for Biomedical Technology (CTB), Universidad Politécnica de Madrid, Madrid, Spain.; Biomedical Research Networking Center in Bioengineering Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain.
Fernández I; Biomedical Research Networking Center in Bioengineering Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain. .; Departamento de Química Orgánica I and Centro de Innovación en Química Avanzada (ORFEO-CINQA), Facultad de Ciencias Químicas, Universidad Complutense de Madrid, 28040, Madrid, Spain. .
Marco-Contelles J; Laboratory of Medicinal Chemistry, Institute of Organic Chemistry (CSIC), Juan de la Cierva 3, 28006, Madrid, Spain. .
Oset-Gasque MJ; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University of Madrid, 28040, Madrid, Spain. .; Instituto Universitario de Investigación en Neuroquímica, Universidad Complutense de Madrid, 28040, Madrid, Spain. .
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Źródło :
Scientific reports [Sci Rep] 2020 Aug 25; Vol. 10 (1), pp. 14150. Date of Electronic Publication: 2020 Aug 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain Ischemia/*drug therapy
Cyclic N-Oxides/*chemistry
Free Radical Scavengers/*therapeutic use
Neurons/*drug effects
Neuroprotection/*drug effects
Neuroprotective Agents/*therapeutic use
Nitrogen Oxides/*therapeutic use
Animals ; Apoptosis/drug effects ; Brain Ischemia/chemically induced ; Cell Line, Tumor ; Disease Models, Animal ; Drug Evaluation, Preclinical ; Free Radical Scavengers/chemical synthesis ; Free Radical Scavengers/pharmacology ; Glucose/pharmacology ; Infarction, Middle Cerebral Artery/drug therapy ; Lipid Peroxidation/drug effects ; Lipoxygenase Inhibitors/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Molecular Structure ; Neuroblastoma/pathology ; Neuroprotective Agents/chemical synthesis ; Neuroprotective Agents/pharmacology ; Nitrogen Oxides/chemical synthesis ; Nitrogen Oxides/pharmacology ; Oligomycins/toxicity ; Oxygen/pharmacology ; Rotenone/toxicity
Czasopismo naukowe
Tytuł :
Oligomycins inhibit Magnaporthe oryzae Triticum and suppress wheat blast disease.
Autorzy :
Chakraborty M; Institute of Biotechnology and Genetic Engineering, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur, Bangladesh.
Mahmud NU; Institute of Biotechnology and Genetic Engineering, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur, Bangladesh.
Muzahid ANM; Institute of Biotechnology and Genetic Engineering, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur, Bangladesh.
Rabby SMF; Institute of Biotechnology and Genetic Engineering, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur, Bangladesh.
Islam T; Institute of Biotechnology and Genetic Engineering, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur, Bangladesh.
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Źródło :
PloS one [PLoS One] 2020 Aug 17; Vol. 15 (8), pp. e0233665. Date of Electronic Publication: 2020 Aug 17 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Magnaporthe/*drug effects
Magnaporthe/*pathogenicity
Oligomycins/*pharmacology
Plant Diseases/*microbiology
Plant Diseases/*prevention & control
Triticum/*microbiology
Biological Control Agents/pharmacology ; Edible Grain/microbiology ; Food Microbiology ; Fungicides, Industrial/pharmacology ; Hyphae/drug effects ; Hyphae/growth & development ; Magnaporthe/growth & development ; Mycelium/drug effects ; Mycelium/growth & development ; Spores, Fungal/drug effects ; Spores, Fungal/growth & development
Czasopismo naukowe
Tytuł :
Glycolysis and mitochondrial function regulate the radical oxygen species production induced by platelet-activating factor in bovine polymorphonuclear leukocytes.
Autorzy :
Quiroga J; Laboratory of Inflammation Pharmacology, Institute of Pharmacology and Morphophysiology, Faculty of Veterinary Sciences, Universidad Austral de Chile, Valdivia, Chile; Laboratory of Immunometabolism, Institute of Pharmacology and Morphophysiology, Faculty of Veterinary Sciences, Universidad Austral de Chile, Valdivia, Chile; Doctoral Program in Veterinary Sciences, Faculty of Veterinary Sciences, Universidad Austral de Chile, Valdivia, Chile.
Alarcón P; Laboratory of Inflammation Pharmacology, Institute of Pharmacology and Morphophysiology, Faculty of Veterinary Sciences, Universidad Austral de Chile, Valdivia, Chile; Laboratory of Immunometabolism, Institute of Pharmacology and Morphophysiology, Faculty of Veterinary Sciences, Universidad Austral de Chile, Valdivia, Chile.
Manosalva C; Institute of Pharmacy, Faculty of Sciences, Universidad Austral de Chile, Valdivia, Chile.
Taubert A; Institute of Parasitology, Biomedical Research Center Seltersberg, Justus Liebig University Giessen, Giessen, Germany.
Hermosilla C; Institute of Parasitology, Biomedical Research Center Seltersberg, Justus Liebig University Giessen, Giessen, Germany.
Hidalgo MA; Laboratory of Inflammation Pharmacology, Institute of Pharmacology and Morphophysiology, Faculty of Veterinary Sciences, Universidad Austral de Chile, Valdivia, Chile; Laboratory of Immunometabolism, Institute of Pharmacology and Morphophysiology, Faculty of Veterinary Sciences, Universidad Austral de Chile, Valdivia, Chile.
Carretta MD; Laboratory of Inflammation Pharmacology, Institute of Pharmacology and Morphophysiology, Faculty of Veterinary Sciences, Universidad Austral de Chile, Valdivia, Chile; Laboratory of Immunometabolism, Institute of Pharmacology and Morphophysiology, Faculty of Veterinary Sciences, Universidad Austral de Chile, Valdivia, Chile.
Burgos RA; Laboratory of Inflammation Pharmacology, Institute of Pharmacology and Morphophysiology, Faculty of Veterinary Sciences, Universidad Austral de Chile, Valdivia, Chile; Laboratory of Immunometabolism, Institute of Pharmacology and Morphophysiology, Faculty of Veterinary Sciences, Universidad Austral de Chile, Valdivia, Chile. Electronic address: .
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Źródło :
Veterinary immunology and immunopathology [Vet Immunol Immunopathol] 2020 Aug; Vol. 226, pp. 110074. Date of Electronic Publication: 2020 May 21.
Typ publikacji :
Journal Article
MeSH Terms :
Glycolysis/*drug effects
Mitochondria/*physiology
Neutrophils/*drug effects
Neutrophils/*physiology
Platelet Activating Factor/*physiology
Reactive Oxygen Species/*analysis
Animals ; Carbonyl Cyanide m-Chlorophenyl Hydrazone/analogs & derivatives ; Carbonyl Cyanide m-Chlorophenyl Hydrazone/pharmacology ; Cattle ; Deoxyglucose/pharmacology ; Female ; Membrane Potentials/drug effects ; Neutrophils/cytology ; Oligomycins/pharmacology ; Platelet Activating Factor/immunology ; Respiratory Burst/drug effects ; Rotenone/pharmacology
Czasopismo naukowe
Tytuł :
Oligomycins A and E, major bioactive secondary metabolites produced by Streptomyces sp. strain HG29 isolated from a Saharan soil.
Autorzy :
Khebizi N; Laboratoire de biologie des systèmes microbiens (LBSM), école normale supérieure de Kouba, Alger, Algeria.
Boudjella H; Laboratoire de biologie des systèmes microbiens (LBSM), école normale supérieure de Kouba, Alger, Algeria. Electronic address: .
Bijani C; Laboratoire de chimie de coordination (LCC), CNRS, université de Toulouse, UPS, INPT, LCC, 205, route de Narbonne, 31077 Toulouse, France.
Bouras N; Laboratoire de biologie des systèmes microbiens (LBSM), école normale supérieure de Kouba, Alger, Algeria; Département de biologie, faculté des sciences de la nature et de la vie et sciences de la terre, université de Ghardaïa, BP 455, 47000 Ghardaïa, Algeria.
Klenk HP; School of biology, Newcastle university, Ridley building, NE1 7RU Newcastle upon Tyne, United Kingdom.
Pont F; Proteomics group, Inserm UMR1037, centre de recherches en cancérologie de Toulouse (CRCT), Toulouse, France.
Mathieu F; Laboratoire de génie chimique, CNRS, INPT, UPS, université de Toulouse, Toulouse, France.
Sabaou N; Laboratoire de biologie des systèmes microbiens (LBSM), école normale supérieure de Kouba, Alger, Algeria.
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Źródło :
Journal de mycologie medicale [J Mycol Med] 2018 Mar; Vol. 28 (1), pp. 150-160. Date of Electronic Publication: 2017 Nov 20.
Typ publikacji :
Journal Article
MeSH Terms :
Soil Microbiology*
Oligomycins/*chemistry
Soil/*chemistry
Streptomyces/*chemistry
Streptomyces/*isolation & purification
Africa, Northern ; Algeria ; Antifungal Agents/pharmacology ; Fermentation ; Fungi/classification ; Fungi/drug effects ; Fungi/isolation & purification ; Fungi/pathogenicity ; Mass Spectrometry ; Microbial Sensitivity Tests ; Oligomycins/isolation & purification ; Oligomycins/pharmacology ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; Secondary Metabolism ; Sequence Analysis, DNA ; Streptomyces/classification ; Streptomyces/genetics
Czasopismo naukowe
Tytuł :
Membrane plasticity facilitates recognition of the inhibitor oligomycin by the mitochondrial ATP synthase rotor.
Autorzy :
Zhou W; Theoretical Molecular Biophysics Laboratory, National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Drive, Room 5N307A, Bethesda, MD 20892, United States.
Faraldo-Gómez JD; Theoretical Molecular Biophysics Laboratory, National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Drive, Room 5N307A, Bethesda, MD 20892, United States. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Bioenergetics [Biochim Biophys Acta Bioenerg] 2018 Sep; Vol. 1859 (9), pp. 789-796. Date of Electronic Publication: 2018 Apr 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
Adenosine Triphosphate/*metabolism
Enzyme Inhibitors/*metabolism
Mitochondrial Membranes/*metabolism
Mitochondrial Proton-Translocating ATPases/*metabolism
Oligomycins/*metabolism
Saccharomyces cerevisiae/*enzymology
Binding Sites ; Enzyme Inhibitors/chemistry ; Mitochondrial Membranes/drug effects ; Mitochondrial Proton-Translocating ATPases/antagonists & inhibitors ; Mitochondrial Proton-Translocating ATPases/chemistry ; Molecular Dynamics Simulation ; Oligomycins/chemistry ; Protein Conformation
Czasopismo naukowe
Tytuł :
PPARβ/δ-dependent MSC metabolism determines their immunoregulatory properties.
Autorzy :
Contreras-Lopez RA; Centro de Investigación Biomédica, Facultad de Medicina, Universidad de Los Andes, Santiago, Chile.; IRMB, Univ Montpellier, INSERM, CHU Montpellier, Inserm U 1183, IRMB, Hôpital Saint-Eloi, 80 Avenue Augustin Fliche, 34295, Montpellier Cedex 5, France.
Elizondo-Vega R; Facultad de Ciencias Biológicas, Departamento de Biología Celular, Laboratorio de Biología Celular, Universidad de Concepción, Concepción, Chile.
Torres MJ; Escuela de Ingeniería Bioquímica, Pontificia Universidad Católica de Valparaiso, Valparaiso, Chile.
Vega-Letter AM; Cells for Cells, Consorcio Regenero, Las Condes, Santiago, Chile.; Laboratory of Nano-Regenerative Medicine, Facultad de Medicina, Universidad de Los Andes, Santiago, Chile.
Luque-Campos N; Centro de Investigación Biomédica, Facultad de Medicina, Universidad de Los Andes, Santiago, Chile.
Paredes-Martinez MJ; Centro de Investigación Biomédica, Facultad de Medicina, Universidad de Los Andes, Santiago, Chile.
Pradenas C; Centro de Investigación Biomédica, Facultad de Medicina, Universidad de Los Andes, Santiago, Chile.
Tejedor G; IRMB, Univ Montpellier, INSERM, CHU Montpellier, Inserm U 1183, IRMB, Hôpital Saint-Eloi, 80 Avenue Augustin Fliche, 34295, Montpellier Cedex 5, France.
Oyarce K; Facultad de Ciencias de la Salud, Universidad San Sebastián, Concepción, Chile.
Salgado M; Facultad de Ciencias Biológicas, Departamento de Biología Celular, Laboratorio de Biología Celular, Universidad de Concepción, Concepción, Chile.
Jorgensen C; IRMB, Univ Montpellier, INSERM, CHU Montpellier, Inserm U 1183, IRMB, Hôpital Saint-Eloi, 80 Avenue Augustin Fliche, 34295, Montpellier Cedex 5, France.
Khoury M; Cells for Cells, Consorcio Regenero, Las Condes, Santiago, Chile.; Laboratory of Nano-Regenerative Medicine, Facultad de Medicina, Universidad de Los Andes, Santiago, Chile.
Kronke G; Department of Internal Medicine 3, University of Erlangen-Nuremberg, 91054, Erlangen, Germany.
Garcia-Robles MA; Facultad de Ciencias Biológicas, Departamento de Biología Celular, Laboratorio de Biología Celular, Universidad de Concepción, Concepción, Chile.
Altamirano C; Escuela de Ingeniería Bioquímica, Pontificia Universidad Católica de Valparaiso, Valparaiso, Chile.
Luz-Crawford P; Centro de Investigación Biomédica, Facultad de Medicina, Universidad de Los Andes, Santiago, Chile. .
Djouad F; IRMB, Univ Montpellier, INSERM, CHU Montpellier, Inserm U 1183, IRMB, Hôpital Saint-Eloi, 80 Avenue Augustin Fliche, 34295, Montpellier Cedex 5, France. .
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Źródło :
Scientific reports [Sci Rep] 2020 Jul 10; Vol. 10 (1), pp. 11423. Date of Electronic Publication: 2020 Jul 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mesenchymal Stem Cells/*metabolism
PPAR-beta/*metabolism
Receptors, Cytoplasmic and Nuclear/*metabolism
Animals ; Bone Marrow Cells/cytology ; CD4-Positive T-Lymphocytes/cytology ; Cell Proliferation ; Gene Silencing ; Glycolysis ; Immunosuppression ; Mice ; Oligomycins/chemistry ; Th1 Cells/cytology ; Th17 Cells/cytology
Czasopismo naukowe
Tytuł :
Heterogeneity of Metabolic Vulnerability in Imatinib -Resistant Gastrointestinal Stromal Tumor.
Autorzy :
Huang WK; Department of Oncology-Pathology, Karolinska Institutet, BioClinicum J6:20, Karolinska University Hospital, SE-17164 Solna, Sweden.; Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, 33305, Taoyuan, Taiwan.
Gao J; Department of Oncology-Pathology, Karolinska Institutet, BioClinicum J6:20, Karolinska University Hospital, SE-17164 Solna, Sweden.
Chen Z; Department of Oncology-Pathology, Karolinska Institutet, BioClinicum J6:20, Karolinska University Hospital, SE-17164 Solna, Sweden.
Shi H; Department of Oncology-Pathology, Karolinska Institutet, BioClinicum J6:20, Karolinska University Hospital, SE-17164 Solna, Sweden.
Yuan J; Department of Cell and Molecular Biology, Karolinska Institutet, Solnavägen 9, SE-17165 Stockholm, Sweden.
Cui HL; Department of Medicine-Solna, Microbial Pathogenesis Unit, Karolinska Institutet, BioClinicum, SE-17164 Solna, Sweden.
Yeh CN; Department of Surgery, Chang Gung Memorial Hospital and GIST Team at Linkou, Chang Gung University College of Medicine, 33305, Taoyuan, Taiwan.
Bränström R; Department of Molecular Medicine and Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden.
Larsson C; Department of Oncology-Pathology, Karolinska Institutet, BioClinicum J6:20, Karolinska University Hospital, SE-17164 Solna, Sweden.
Li S; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, SE-17177 Stockholm, Sweden.
Lui WO; Department of Oncology-Pathology, Karolinska Institutet, BioClinicum J6:20, Karolinska University Hospital, SE-17164 Solna, Sweden.
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Źródło :
Cells [Cells] 2020 May 26; Vol. 9 (6). Date of Electronic Publication: 2020 May 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Resistance, Neoplasm*/drug effects
Gastrointestinal Stromal Tumors/*drug therapy
Gastrointestinal Stromal Tumors/*metabolism
Imatinib Mesylate/*therapeutic use
Antimycin A/pharmacology ; Cell Death/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Energy Metabolism/drug effects ; Gastrointestinal Stromal Tumors/genetics ; Gastrointestinal Stromal Tumors/pathology ; Gene Expression Regulation, Neoplastic/drug effects ; Glycolysis/drug effects ; Gossypol/pharmacology ; Humans ; Imatinib Mesylate/pharmacology ; Oligomycins/pharmacology ; Organelle Biogenesis ; Oxidative Phosphorylation/drug effects ; Phenotype ; Pyruvates/pharmacology
Czasopismo naukowe
Tytuł :
Glycolytic reprogramming of macrophages activated by NOD1 and TLR4 agonists: No association with proinflammatory cytokine production in normoxia.
Autorzy :
Murugina NE; Laboratory of Clinical Immunology, National Research Center, Institute of Immunology, Federal Medical-Biological Agency of Russia, Kashirskoe shosse 24, 115522 Moscow, Russia.
Budikhina AS; Laboratory of Clinical Immunology, National Research Center, Institute of Immunology, Federal Medical-Biological Agency of Russia, Kashirskoe shosse 24, 115522 Moscow, Russia.
Dagil YA; Laboratory of Clinical Immunology, National Research Center, Institute of Immunology, Federal Medical-Biological Agency of Russia, Kashirskoe shosse 24, 115522 Moscow, Russia.
Maximchik PV; Faculty of Fundamental Medicine, Lomonosov Moscow State University, Leninskie Gory 1, 119991 Moscow, Russia.
Balyasova LS; Laboratory of Clinical Immunology, National Research Center, Institute of Immunology, Federal Medical-Biological Agency of Russia, Kashirskoe shosse 24, 115522 Moscow, Russia.
Murugin VV; Laboratory of Clinical Immunology, National Research Center, Institute of Immunology, Federal Medical-Biological Agency of Russia, Kashirskoe shosse 24, 115522 Moscow, Russia.
Melnikov MV; Laboratory of Clinical Immunology, National Research Center, Institute of Immunology, Federal Medical-Biological Agency of Russia, Kashirskoe shosse 24, 115522 Moscow, Russia; Department of Neurology, Neurosurgery and Medical Genetics, Pirogov Russian National Research Medical University, Ostrovityanova street 1, 117997 Moscow, Russia.
Sharova VS; Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Vavilova street 26, 119334 Moscow, Russia.
Nikolaeva AM; Laboratory of Clinical Immunology, National Research Center, Institute of Immunology, Federal Medical-Biological Agency of Russia, Kashirskoe shosse 24, 115522 Moscow, Russia; Biological Faculty, Lomonosov Moscow State University, Leninskie Gory 1, 119991 Moscow, Russia.
Chkadua GZ; Laboratory of Experimental Diagnostics and Biotherapy of Tumors, N. N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation, Kashirskoe shosse 24 Building 2, 115522 Moscow, Russia.
Pinegin BV; Laboratory of Clinical Immunology, National Research Center, Institute of Immunology, Federal Medical-Biological Agency of Russia, Kashirskoe shosse 24, 115522 Moscow, Russia.
Pashenkov MV; Laboratory of Clinical Immunology, National Research Center, Institute of Immunology, Federal Medical-Biological Agency of Russia, Kashirskoe shosse 24, 115522 Moscow, Russia. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Mar 06; Vol. 295 (10), pp. 3099-3114. Date of Electronic Publication: 2020 Jan 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytokines/*metabolism
Glycolysis/*drug effects
Lipopolysaccharides/*pharmacology
Macrophages/*metabolism
Nod1 Signaling Adaptor Protein/*agonists
Toll-Like Receptor 4/*agonists
Animals ; Carboxy-Lyases/metabolism ; Cell Hypoxia ; Dendritic Cells/drug effects ; Dendritic Cells/immunology ; Dendritic Cells/metabolism ; Deoxyglucose/pharmacology ; Humans ; Macrophages/drug effects ; Macrophages/immunology ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mice ; Mice, Inbred C57BL ; Monocytes/cytology ; Monocytes/metabolism ; Nod1 Signaling Adaptor Protein/metabolism ; Nod2 Signaling Adaptor Protein/agonists ; Nod2 Signaling Adaptor Protein/metabolism ; Oligomycins/pharmacology ; Proto-Oncogene Proteins c-akt/metabolism ; Toll-Like Receptor 4/metabolism ; Unfolded Protein Response/drug effects
Czasopismo naukowe
Tytuł :
Monocyte metabolic reprogramming promotes pro-inflammatory activity and Staphylococcus aureus biofilm clearance.
Autorzy :
Yamada KJ; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.
Heim CE; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.
Xi X; Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.
Attri KS; Eppley Institute, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.
Wang D; Eppley Institute, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.
Zhang W; Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.
Singh PK; Eppley Institute, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.
Bronich TK; Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.
Kielian T; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Mar 06; Vol. 16 (3), pp. e1008354. Date of Electronic Publication: 2020 Mar 06 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Biofilms/*drug effects
Cellular Reprogramming/*drug effects
Implants, Experimental/*microbiology
Monocytes/*metabolism
Oligomycins/*pharmacology
Staphylococcal Infections/*metabolism
Staphylococcus aureus/*physiology
Animals ; Inflammation/drug therapy ; Inflammation/metabolism ; Inflammation/pathology ; Mice ; Monocytes/pathology ; Oxidative Phosphorylation/drug effects ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/pathology
Czasopismo naukowe
Tytuł :
Acquired Resistance to HER2-Targeted Therapies Creates Vulnerability to ATP Synthase Inhibition.
Autorzy :
Gale M; Department of Pathology, Yale School of Medicine, New Haven, Connecticut.
Li Y; Department of Pathology, Yale School of Medicine, New Haven, Connecticut.; Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Cao J; Department of Pathology, Yale School of Medicine, New Haven, Connecticut.; Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut.
Liu ZZ; Department of Pathology, Yale School of Medicine, New Haven, Connecticut.
Holmbeck MA; Department of Pathology, Yale School of Medicine, New Haven, Connecticut.
Zhang M; Department of Pathology, Yale School of Medicine, New Haven, Connecticut.
Lang SM; Department of Pathology, Yale School of Medicine, New Haven, Connecticut.
Wu L; Department of Pathology, Yale School of Medicine, New Haven, Connecticut.
Do Carmo M; Department of Pathology, Yale School of Medicine, New Haven, Connecticut.
Gupta S; Department of Pathology, Yale School of Medicine, New Haven, Connecticut.
Aoshima K; Department of Pathology, Yale School of Medicine, New Haven, Connecticut.; Laboratory of Comparative Pathology, Department of Clinical Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
DiGiovanna MP; Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut.; Section of Medical Oncology, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
Stern DF; Department of Pathology, Yale School of Medicine, New Haven, Connecticut.; Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut.
Rimm DL; Department of Pathology, Yale School of Medicine, New Haven, Connecticut.; Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut.
Shadel GS; Salk Institute for Biological Studies, La Jolla, California.
Chen X; Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China. .; Hunan Key Laboratory of Skin Cancer and Psoriasis, Changsha, Hunan, China.
Yan Q; Department of Pathology, Yale School of Medicine, New Haven, Connecticut. .; Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut.; Yale Stem Cell Center, Yale School of Medicine, New Haven, Connecticut.
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Źródło :
Cancer research [Cancer Res] 2020 Feb 01; Vol. 80 (3), pp. 524-535. Date of Electronic Publication: 2019 Nov 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Breast Neoplasms/*drug therapy
Drug Resistance, Neoplasm/*drug effects
Enzyme Inhibitors/*pharmacology
Mitochondrial Proton-Translocating ATPases/*antagonists & inhibitors
Receptor, ErbB-2/*antagonists & inhibitors
Animals ; Apoptosis ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Proliferation ; Female ; Humans ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Oligomycins/administration & dosage ; Trastuzumab/administration & dosage ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Verification of oligomycin A structure: synthesis and biological evaluation of 33-dehydrooligomycin A.
Autorzy :
Lysenkova LN; G. F. Gause Institute of New Antibiotics, Moscow, Russian Federation.
Saveljev OY; M. V. Lomonosov Moscow State University, Moscow, Russian Federation.
Grammatikova NE; G. F. Gause Institute of New Antibiotics, Moscow, Russian Federation.
Tsvetkov VB; A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Moscow, Russian Federation.; Institute for Physical-Chemical Medicine, Moscow, Russian Federation.; Research Institute of Influenza, St-Petersburg, Russian Federation.
Bekker OB; N. I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russian Federation.
Danilenko VN; N. I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russian Federation.
Dezhenkova LG; G. F. Gause Institute of New Antibiotics, Moscow, Russian Federation.
Bykov EE; G. F. Gause Institute of New Antibiotics, Moscow, Russian Federation.
Omelchuk OA; G. F. Gause Institute of New Antibiotics, Moscow, Russian Federation.
Korolev AM; G. F. Gause Institute of New Antibiotics, Moscow, Russian Federation.
Shchekotikhin AE; G. F. Gause Institute of New Antibiotics, Moscow, Russian Federation.; D. I. Mendeleev University of Chemical Technology of Russia, Moscow, Russian Federation.
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Źródło :
The Journal of antibiotics [J Antibiot (Tokyo)] 2017 Jul; Vol. 70 (8), pp. 871-877. Date of Electronic Publication: 2017 Apr 19.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Anti-Bacterial Agents/*pharmacology
Antifungal Agents/*pharmacology
Antineoplastic Agents/*pharmacology
Oligomycins/*pharmacology
Anti-Bacterial Agents/chemistry ; Antifungal Agents/chemistry ; Antineoplastic Agents/chemistry ; Candida/drug effects ; Cell Line, Tumor ; Humans ; Magnetic Resonance Spectroscopy ; Oligomycins/chemistry ; Streptomyces/drug effects
Czasopismo naukowe
Tytuł :
Oligomycins and pamamycin homologs impair motility and induce lysis of zoospores of the grapevine downy mildew pathogen, Plasmopara viticola.
Autorzy :
Dame ZT; Institute of Organic and Biomolecular Chemistry, Georg-August University Goettingen, Tammanstrasse 2, D-37077 Göttingen, Germany.
Islam MT; Department of Crop Science, Division of Plant Pathology and Plant Protection, Georg-August University Goettingen, Grisebachstrasse 6, D-37077 Göttingen, Germany Department of Biotechnology, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Salna, Gazipur 1706, Bangladesh .
Helmke E; Alfred Wegner Institute for Polar and Marine Research, Am Handelshafen 12, D-27570 Bremerhaven, Germany.
von Tiedemann A; Department of Crop Science, Division of Plant Pathology and Plant Protection, Georg-August University Goettingen, Grisebachstrasse 6, D-37077 Göttingen, Germany.
Laatsch H; Institute of Organic and Biomolecular Chemistry, Georg-August University Goettingen, Tammanstrasse 2, D-37077 Göttingen, Germany.
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Źródło :
FEMS microbiology letters [FEMS Microbiol Lett] 2016 Aug; Vol. 363 (16). Date of Electronic Publication: 2016 Jun 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Bacterial Agents/*chemistry
Anti-Bacterial Agents/*pharmacology
Oligomycins/*pharmacology
Oomycetes/*drug effects
Oomycetes/*pathogenicity
Spores/*drug effects
Vitis/*microbiology
Anti-Bacterial Agents/isolation & purification ; Anti-Bacterial Agents/metabolism ; Inhibitory Concentration 50 ; Macrolides/agonists ; Macrolides/chemistry ; Macrolides/isolation & purification ; Macrolides/pharmacology ; Oligomycins/chemistry ; Oligomycins/isolation & purification ; Oomycetes/physiology ; Plant Diseases/microbiology ; Plant Leaves/microbiology ; Streptomyces/chemistry ; Streptomyces/metabolism
Czasopismo naukowe
Tytuł :
Measuring Respiration in Isolated Murine Brain Mitochondria: Implications for Mechanistic Stroke Studies.
Autorzy :
Sperling JA; Department of Pharmacology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA, 70112, USA.
Sakamuri SSVP; Department of Pharmacology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA, 70112, USA.
Albuck AL; Department of Pharmacology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA, 70112, USA.; Tulane Brain Institute, Tulane University, 200 Flower Hall, New Orleans, LA, 70118, USA.
Sure VN; Department of Pharmacology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA, 70112, USA.
Evans WR; Department of Pharmacology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA, 70112, USA.; Tulane Brain Institute, Tulane University, 200 Flower Hall, New Orleans, LA, 70118, USA.
Peterson NR; Department of Pharmacology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA, 70112, USA.
Rutkai I; Department of Pharmacology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA, 70112, USA.; Tulane Brain Institute, Tulane University, 200 Flower Hall, New Orleans, LA, 70118, USA.
Mostany R; Department of Pharmacology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA, 70112, USA.; Tulane Brain Institute, Tulane University, 200 Flower Hall, New Orleans, LA, 70118, USA.
Satou R; Department of Physiology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA, 70112, USA.
Katakam PVG; Department of Pharmacology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA, 70112, USA. .; Tulane Brain Institute, Tulane University, 200 Flower Hall, New Orleans, LA, 70118, USA. .
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Źródło :
Neuromolecular medicine [Neuromolecular Med] 2019 Dec; Vol. 21 (4), pp. 493-504. Date of Electronic Publication: 2019 Jun 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Oxygen Consumption*/drug effects
Brain/*metabolism
Fluorometry/*methods
High-Throughput Screening Assays/*methods
Microchemistry/*methods
Mitochondria/*metabolism
Oximetry/*methods
Adenosine Diphosphate/pharmacology ; Animals ; Brain/ultrastructure ; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone/pharmacology ; Electron Transport Complex I/metabolism ; Electron Transport Complex II/metabolism ; Fluorometry/instrumentation ; High-Throughput Screening Assays/instrumentation ; Hydrogen-Ion Concentration ; Male ; Mice ; Mice, Inbred C57BL ; Microchemistry/instrumentation ; Mitochondria/drug effects ; Mitochondrial Membranes/drug effects ; Mitochondrial Membranes/metabolism ; Mitochondrial Proteins/analysis ; Mitochondrial Proton-Translocating ATPases/antagonists & inhibitors ; Oligomycins/pharmacology ; Oxidative Phosphorylation ; Oximetry/instrumentation ; Oxygen/analysis ; Protons
Czasopismo naukowe
Tytuł :
A Compendium of Genetic Modifiers of Mitochondrial Dysfunction Reveals Intra-organelle Buffering.
Autorzy :
To TL; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Cuadros AM; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Shah H; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA 02114, USA, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Hung WHW; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Li Y; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA 02114, USA, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Kim SH; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA 02114, USA, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Rubin DHF; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA 02114, USA, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Boe RH; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Rath S; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA 02114, USA, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Eaton JK; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Piccioni F; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Goodale A; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Kalani Z; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Doench JG; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Root DE; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Schreiber SL; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA 02114, USA, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Vafai SB; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Mootha VK; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA 02114, USA, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address: .
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Źródło :
Cell [Cell] 2019 Nov 14; Vol. 179 (5), pp. 1222-1238.e17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, Modifier*
Mitochondria/*genetics
Mitochondria/*pathology
Autoantigens/metabolism ; Cell Death/drug effects ; Cytosol/drug effects ; Cytosol/metabolism ; Electron Transport Complex I/metabolism ; Epistasis, Genetic/drug effects ; Ferroptosis/drug effects ; Ferroptosis/genetics ; Genome ; Glutathione Peroxidase/metabolism ; Glycolysis/drug effects ; Glycolysis/genetics ; Humans ; K562 Cells ; Mitochondria/drug effects ; Oligomycins/toxicity ; Oxidation-Reduction ; Oxidative Phosphorylation/drug effects ; Pentose Phosphate Pathway/drug effects ; Pentose Phosphate Pathway/genetics ; Reactive Oxygen Species/metabolism ; Ribonucleoproteins/metabolism
Czasopismo naukowe

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