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Tytuł:
Synergistic lethality in chronic myeloid leukemia - targeting oxidative phosphorylation and unfolded protein response effectively complements tyrosine kinase inhibitor treatment.
Autorzy:
Häselbarth L; Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Erlangen, Germany. .; Comprehensive Cancer Center Erlangen-European Metropolitan Area Nuremberg (CCC-ER-EMN), Erlangen, Germany. .; Interdisciplinary Centre for Clinical Research (IZKF), Erlangen, Germany. .
Gamali S; Department of Internal Medicine 5, Hematology and Oncology, University Hospital Erlangen, Erlangen, Germany.
Saul D; Department of Internal Medicine 5, Hematology and Oncology, University Hospital Erlangen, Erlangen, Germany.
Krumbholz M; Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Erlangen, Germany.; Comprehensive Cancer Center Erlangen-European Metropolitan Area Nuremberg (CCC-ER-EMN), Erlangen, Germany.
Böttcher-Loschinski R; Department of Hematology and Oncology, Medical Center, Otto-Von-Guericke University Magdeburg, Magdeburg, Germany.
Böttcher M; Department of Hematology and Oncology, Medical Center, Otto-Von-Guericke University Magdeburg, Magdeburg, Germany.; Health Campus Immunology, Inflammation and Infectiology (GC-I3), Medical Center, Otto-Von-Guericke University Magdeburg, Magdeburg, Germany.
Zou D; Department of Hematology and Oncology, Medical Center, Otto-Von-Guericke University Magdeburg, Magdeburg, Germany.
Metzler M; Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Erlangen, Germany.; Comprehensive Cancer Center Erlangen-European Metropolitan Area Nuremberg (CCC-ER-EMN), Erlangen, Germany.; Interdisciplinary Centre for Clinical Research (IZKF), Erlangen, Germany.
Karow A; Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Erlangen, Germany.; Comprehensive Cancer Center Erlangen-European Metropolitan Area Nuremberg (CCC-ER-EMN), Erlangen, Germany.; Interdisciplinary Centre for Clinical Research (IZKF), Erlangen, Germany.
Mougiakakos D; Department of Hematology and Oncology, Medical Center, Otto-Von-Guericke University Magdeburg, Magdeburg, Germany.; Health Campus Immunology, Inflammation and Infectiology (GC-I3), Medical Center, Otto-Von-Guericke University Magdeburg, Magdeburg, Germany.
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Źródło:
BMC cancer [BMC Cancer] 2023 Nov 27; Vol. 23 (1), pp. 1153. Date of Electronic Publication: 2023 Nov 27.
Typ publikacji:
Journal Article
MeSH Terms:
Tyrosine Kinase Inhibitors*
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/drug therapy
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/metabolism
Humans ; Fusion Proteins, bcr-abl ; Oxidative Phosphorylation ; Thapsigargin/pharmacology ; Thapsigargin/therapeutic use ; Drug Resistance, Neoplasm ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Enzyme Inhibitors/pharmacology ; Oligomycins/pharmacology ; Adenosine Triphosphate/metabolism ; Apoptosis
Czasopismo naukowe
Tytuł:
Real-Time Visualization of Cytosolic and Mitochondrial ATP Dynamics in Response to Metabolic Stress in Cultured Cells.
Autorzy:
White D 3rd; Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.; Department of Pharmacology and Experimental Therapeutics, School of Graduate Studies, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.; School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Lauterboeck L; Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.; Department of Pharmacology and Experimental Therapeutics, School of Graduate Studies, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.; Cell Biology, Life Science Solutions, Thermo Fisher Scientific, Frederick, MD 21702, USA.
Mobasheran P; Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.; Department of Pharmacology and Experimental Therapeutics, School of Graduate Studies, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Kitaguchi T; Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Kanagawa, Japan.
Chaanine AH; HealthPartners Group, Regions Hospital, Saint Paul, MN 55101, USA.
Yang Q; Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.; Department of Pharmacology and Experimental Therapeutics, School of Graduate Studies, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
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Źródło:
Cells [Cells] 2023 Feb 22; Vol. 12 (5). Date of Electronic Publication: 2023 Feb 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Adenosine Triphosphate*/metabolism
Stress, Physiological*
Humans ; Cytosol/metabolism ; HEK293 Cells ; Adenosine Diphosphate/metabolism ; Atractyloside/metabolism ; Oligomycins
Czasopismo naukowe
Tytuł:
Proliferating Astrocytes in Primary Culture Do Not Depend upon Mitochondrial Respiratory Complex I Activity or Oxidative Phosphorylation.
Autorzy:
Silva EA; Department of Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas 13083-887, SP, Brazil.
Dalla Costa AP; Department of Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas 13083-887, SP, Brazil.
Ruas JS; Department of Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas 13083-887, SP, Brazil.
Siqueira-Santos ES; Department of Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas 13083-887, SP, Brazil.
Francisco A; Department of Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas 13083-887, SP, Brazil.
Castilho RF; Department of Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas 13083-887, SP, Brazil.
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Źródło:
Cells [Cells] 2023 Feb 21; Vol. 12 (5). Date of Electronic Publication: 2023 Feb 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Oxidative Phosphorylation*
Electron Transport Complex I*/metabolism
Mice ; Animals ; Astrocytes/metabolism ; Mitochondria/metabolism ; Oligomycins/pharmacology
Czasopismo naukowe
Tytuł:
Relative Importance of Different Elements of Mitochondrial Oxidative Phosphorylation in Maintaining the Barrier Integrity of Retinal Endothelial Cells: Implications for Vascular-Associated Retinal Diseases.
Autorzy:
Eltanani S; Department of Ophthalmology, Visual, and Anatomical Sciences, Wayne State University, Detroit, MI 48201, USA.
Yumnamcha T; Department of Ophthalmology, Visual, and Anatomical Sciences, Wayne State University, Detroit, MI 48201, USA.
Gregory A; Department of Ophthalmology, Visual, and Anatomical Sciences, Wayne State University, Detroit, MI 48201, USA.
Elshal M; Department of Ophthalmology, Visual, and Anatomical Sciences, Wayne State University, Detroit, MI 48201, USA.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.; Department of Pharmacology, Wayne State University, Detroit, MI 48201, USA.
Shawky M; Department of Ophthalmology, Visual, and Anatomical Sciences, Wayne State University, Detroit, MI 48201, USA.; Department of Biochemistry, Faculty of Pharmacy, Horus University, New Damietta 34518, Egypt.
Ibrahim AS; Department of Ophthalmology, Visual, and Anatomical Sciences, Wayne State University, Detroit, MI 48201, USA.; Department of Pharmacology, Wayne State University, Detroit, MI 48201, USA.; Department of Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
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Źródło:
Cells [Cells] 2022 Dec 19; Vol. 11 (24). Date of Electronic Publication: 2022 Dec 19.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Oxidative Phosphorylation*
Diabetic Retinopathy*/metabolism
Infant, Newborn ; Humans ; Rotenone/pharmacology ; Endothelial Cells/metabolism ; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone/metabolism ; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone/pharmacology ; Mitochondria/metabolism ; Oligomycins/pharmacology
Czasopismo naukowe
Tytuł:
Role of Glycolysis and Fatty Acid Synthesis in the Activation and T Cell-Modulating Potential of Dendritic Cells Stimulated with a TLR5-Ligand Allergen Fusion Protein.
Autorzy:
Goretzki A; Molecular Allergology, Paul-Ehrlich-Institut, Paul-Ehrlich-Straße 51-59, 63225 Langen, Germany.
Lin YJ; Molecular Allergology, Paul-Ehrlich-Institut, Paul-Ehrlich-Straße 51-59, 63225 Langen, Germany.
Zimmermann J; Molecular Allergology, Paul-Ehrlich-Institut, Paul-Ehrlich-Straße 51-59, 63225 Langen, Germany.
Rainer H; Molecular Allergology, Paul-Ehrlich-Institut, Paul-Ehrlich-Straße 51-59, 63225 Langen, Germany.
Junker AC; Molecular Allergology, Paul-Ehrlich-Institut, Paul-Ehrlich-Straße 51-59, 63225 Langen, Germany.
Wolfheimer S; Molecular Allergology, Paul-Ehrlich-Institut, Paul-Ehrlich-Straße 51-59, 63225 Langen, Germany.
Vieths S; Molecular Allergology, Paul-Ehrlich-Institut, Paul-Ehrlich-Straße 51-59, 63225 Langen, Germany.
Scheurer S; Molecular Allergology, Paul-Ehrlich-Institut, Paul-Ehrlich-Straße 51-59, 63225 Langen, Germany.
Schülke S; Molecular Allergology, Paul-Ehrlich-Institut, Paul-Ehrlich-Straße 51-59, 63225 Langen, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Oct 21; Vol. 23 (20). Date of Electronic Publication: 2022 Oct 21.
Typ publikacji:
Journal Article
MeSH Terms:
Toll-Like Receptor 5*/metabolism
Vaccines*/metabolism
Allergens ; Interleukin-10/metabolism ; Flagellin/metabolism ; Hexokinase/metabolism ; Glutaminase/metabolism ; Ligands ; Antimycin A/metabolism ; Antimycin A/pharmacology ; Cerulenin/metabolism ; Cerulenin/pharmacology ; Dendritic Cells ; Recombinant Proteins/metabolism ; Cytokines/metabolism ; Adjuvants, Immunologic/pharmacology ; Recombinant Fusion Proteins/metabolism ; Glycolysis ; TOR Serine-Threonine Kinases/metabolism ; Deoxyglucose/pharmacology ; Oligomycins/pharmacology ; Fatty Acids/metabolism
Czasopismo naukowe
Tytuł:
Contributing role of mitochondrial energy metabolism on platelet adhesion, activation and thrombus formation under blood flow conditions.
Autorzy:
Tamura N; Department of Health and Nutrition, Faculty of Health Sciences, Niigata University of Health and Welfare, Niigata, Japan.
Goto S; Department of Medicine (Cardiology), Tokai University School of Medicine, Isehara, Japan.
Yokota H; Image Processing Research Team, Center for Advanced Photonics, Riken, Wako, Japan.
Goto S; Department of Medicine (Cardiology), Tokai University School of Medicine, Isehara, Japan.
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Źródło:
Platelets [Platelets] 2022 Oct 03; Vol. 33 (7), pp. 1083-1089. Date of Electronic Publication: 2022 Mar 29.
Typ publikacji:
Journal Article
MeSH Terms:
Thrombosis*/metabolism
von Willebrand Factor*/metabolism
Adult ; Antimycin A/metabolism ; Antimycin A/pharmacology ; Blood Platelets/metabolism ; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone/metabolism ; Collagen/metabolism ; Energy Metabolism ; Glucose/metabolism ; Humans ; Mitochondria/metabolism ; Oligomycins/metabolism ; Oligomycins/pharmacology ; Platelet Adhesiveness
Czasopismo naukowe
Tytuł:
Modulation of ATP Production Influences Inorganic Polyphosphate Levels in Non-Athletes' Platelets at the Resting State.
Autorzy:
Ushiki T; Division of Hematology and Oncology, Graduate School of Health Sciences, Niigata University, Niigata 951-8518, Japan.; Department of Transfusion Medicine, Cell Therapy and Regenerative Medicine, Niigata University Medical and Dental Hospital, Niigata 951-8520, Japan.; Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Niigata 951-8510, Japan.
Mochizuki T; Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8510, Japan.
Suzuki K; Department of Transfusion Medicine, Cell Therapy and Regenerative Medicine, Niigata University Medical and Dental Hospital, Niigata 951-8520, Japan.
Kamimura M; Department of Transfusion Medicine, Cell Therapy and Regenerative Medicine, Niigata University Medical and Dental Hospital, Niigata 951-8520, Japan.
Ishiguro H; Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Niigata 951-8510, Japan.
Suwabe T; Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Niigata 951-8510, Japan.
Kawase T; Division of Oral Bioengineering, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8514, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Sep 25; Vol. 23 (19). Date of Electronic Publication: 2022 Sep 25.
Typ publikacji:
Journal Article
MeSH Terms:
Polyphosphates*/metabolism
Rotenone*
Adenosine Triphosphate/metabolism ; Amino Acids ; Citrates ; Glucose ; Humans ; NAD ; Oligomycins
Czasopismo naukowe
Tytuł:
Mitochondrial dysfunction and epithelial to mesenchymal transition in head neck cancer cell lines.
Autorzy:
Greier MC; Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Runge A; Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Innsbruck, Innsbruck, Austria. .
Dudas J; Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Pider V; Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Skvortsova II; Department of Therapeutic Radiology and Oncology, Medical University of Innsbruck, Innsbruck, Austria.; EXTRO-Lab, Tyrolean Cancer Research Institute, Department of Therapeutic Radiology and Oncology, Medical University of Innsbruck, Innsbruck, Austria.
Savic D; Department of Therapeutic Radiology and Oncology, Medical University of Innsbruck, Innsbruck, Austria.; EXTRO-Lab, Tyrolean Cancer Research Institute, Department of Therapeutic Radiology and Oncology, Medical University of Innsbruck, Innsbruck, Austria.
Riechelmann H; Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Innsbruck, Innsbruck, Austria.
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Źródło:
Scientific reports [Sci Rep] 2022 Aug 02; Vol. 12 (1), pp. 13255. Date of Electronic Publication: 2022 Aug 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Epithelial-Mesenchymal Transition*
Head and Neck Neoplasms*
Cadherins/metabolism ; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone/pharmacology ; Cell Line, Tumor ; Humans ; Keratins ; Mitochondria/metabolism ; Oligomycins/pharmacology ; Vimentin/metabolism
Czasopismo naukowe
Tytuł:
Mitochondrial and glycolytic extracellular flux analysis optimization for isolated pig intestinal epithelial cells.
Autorzy:
Bekebrede AF; Human and Animal Physiology, Wageningen University and Research, 6708 WD, Wageningen, The Netherlands.; Animal Nutrition Group, Wageningen University and Research, 6708 WD, Wageningen, The Netherlands.
Keijer J; Human and Animal Physiology, Wageningen University and Research, 6708 WD, Wageningen, The Netherlands.
Gerrits WJJ; Animal Nutrition Group, Wageningen University and Research, 6708 WD, Wageningen, The Netherlands.
de Boer VCJ; Human and Animal Physiology, Wageningen University and Research, 6708 WD, Wageningen, The Netherlands. .
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Źródło:
Scientific reports [Sci Rep] 2021 Oct 07; Vol. 11 (1), pp. 19961. Date of Electronic Publication: 2021 Oct 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Glycolysis*
Intestinal Mucosa/*metabolism
Mitochondria/*metabolism
Animals ; Anti-Bacterial Agents/pharmacology ; Epithelial Cells/metabolism ; Extracellular Fluid ; Intestinal Mucosa/cytology ; Oligomycins/pharmacology ; Swine
Czasopismo naukowe
Tytuł:
Relative Contribution of Different Mitochondrial Oxidative Phosphorylation Components to the Retinal Pigment Epithelium Barrier Function: Implications for RPE-Related Retinal Diseases.
Autorzy:
Guerra MH; Department of Ophthalmology, Visual and Anatomical Sciences, School of Medicine, Wayne State University, 540 East Canfield, Detroit, MI 48201, USA.
Yumnamcha T; Department of Ophthalmology, Visual and Anatomical Sciences, School of Medicine, Wayne State University, 540 East Canfield, Detroit, MI 48201, USA.
Singh LP; Department of Ophthalmology, Visual and Anatomical Sciences, School of Medicine, Wayne State University, 540 East Canfield, Detroit, MI 48201, USA.
Ibrahim AS; Department of Ophthalmology, Visual and Anatomical Sciences, School of Medicine, Wayne State University, 540 East Canfield, Detroit, MI 48201, USA.; Department of Pharmacology, School of Medicine, Wayne State University, 540 East Canfield, Detroit, MI 48201, USA.; Department of Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 29; Vol. 22 (15). Date of Electronic Publication: 2021 Jul 29.
Typ publikacji:
Journal Article
MeSH Terms:
Blood-Retinal Barrier/*metabolism
Diabetic Retinopathy/*metabolism
Epithelial Cells/*metabolism
Macular Degeneration/*metabolism
Mitochondria/*metabolism
Oxidative Phosphorylation/*drug effects
Retinal Pigment Epithelium/*metabolism
Blood-Retinal Barrier/drug effects ; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone/pharmacokinetics ; Cell Line ; Cell Survival/drug effects ; Electric Impedance ; Electron Transport/drug effects ; Enzyme Inhibitors/pharmacokinetics ; Humans ; Mitochondria/drug effects ; Mitochondrial Proton-Translocating ATPases/antagonists & inhibitors ; Oligomycins/pharmacokinetics ; Retinal Pigment Epithelium/drug effects ; Rotenone/pharmacokinetics
Czasopismo naukowe
Tytuł:
Curbing action potential generation or ATP-synthase leads to a decrease in in-cell pyruvate dehydrogenase activity in rat cerebrum slices.
Autorzy:
Grieb B; Department of Radiology, Hadassah Medical Center, The Faculty of Medicine, Hebrew University of Jerusalem, 9112001, Jerusalem, Israel. .; Department of Psychiatry and Psychotherapie I (Weissenau), Ulm University, ZfP Suedwuerttemberg, Ravensburg, Germany. .
Uppala S; Department of Radiology, Hadassah Medical Center, The Faculty of Medicine, Hebrew University of Jerusalem, 9112001, Jerusalem, Israel.
Sapir G; Department of Radiology, Hadassah Medical Center, The Faculty of Medicine, Hebrew University of Jerusalem, 9112001, Jerusalem, Israel.
Shaul D; Department of Radiology, Hadassah Medical Center, The Faculty of Medicine, Hebrew University of Jerusalem, 9112001, Jerusalem, Israel.
Gomori JM; Department of Radiology, Hadassah Medical Center, The Faculty of Medicine, Hebrew University of Jerusalem, 9112001, Jerusalem, Israel.
Katz-Brull R; Department of Radiology, Hadassah Medical Center, The Faculty of Medicine, Hebrew University of Jerusalem, 9112001, Jerusalem, Israel. .; The Wohl Institute for Translational Medicine, Jerusalem, Israel. .
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Źródło:
Scientific reports [Sci Rep] 2021 May 13; Vol. 11 (1), pp. 10211. Date of Electronic Publication: 2021 May 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cerebrum/*metabolism
Mitochondrial Proton-Translocating ATPases/*metabolism
Pyruvate Dehydrogenase Complex/*metabolism
Action Potentials/physiology ; Adenosine Triphosphate/metabolism ; Animals ; Brain/metabolism ; Cerebrum/physiology ; Female ; Magnetic Resonance Spectroscopy/methods ; Oligomycins/pharmacology ; Oxidation-Reduction ; Oxidoreductases/metabolism ; Pyruvic Acid/metabolism ; Rats ; Rats, Sprague-Dawley ; Tetrodotoxin/pharmacology
Czasopismo naukowe
Tytuł:
A Multi-Omics Study Revealing the Metabolic Effects of Estrogen in Liver Cancer Cells HepG2.
Autorzy:
Shen M; Department of Biology, Miami University, Oxford, OH 45056, USA.
Xu M; Department of Biology, Miami University, Oxford, OH 45056, USA.; Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA.
Zhong F; Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA.
Crist MC; Department of Biology, Miami University, Oxford, OH 45056, USA.
Prior AB; Department of Biology, Miami University, Oxford, OH 45056, USA.
Yang K; Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA.
Allaire DM; Department of Biology, Miami University, Oxford, OH 45056, USA.
Choueiry F; Department of Human Sciences, College of Education and Human Ecology, Columbus, OH 43210, USA.; James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.
Zhu J; Department of Human Sciences, College of Education and Human Ecology, Columbus, OH 43210, USA.; James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.
Shi H; Department of Biology, Miami University, Oxford, OH 45056, USA.
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Źródło:
Cells [Cells] 2021 Feb 20; Vol. 10 (2). Date of Electronic Publication: 2021 Feb 20.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Metabolomics*
Estrogens/*metabolism
Liver Neoplasms/*metabolism
Cell Count ; Cell Proliferation/drug effects ; Deoxyglucose/pharmacology ; Estradiol/pharmacology ; Gene Expression Regulation, Neoplastic/drug effects ; Hep G2 Cells ; Humans ; Metabolic Networks and Pathways/drug effects ; Metabolome/drug effects ; Nitriles/pharmacology ; Oligomycins/pharmacology ; Pyrazoles/pharmacology ; Receptors, Estrogen/metabolism ; Transcriptome/genetics
Czasopismo naukowe
Tytuł:
Cells Lacking PA200 Adapt to Mitochondrial Dysfunction by Enhancing Glycolysis via Distinct Opa1 Processing.
Autorzy:
Douida A; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary.; Doctoral School of Molecular Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Batista F; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Boto P; Stem Cell Differentiation Laboratory, Department of Biochemistry and Molecular Biology, University of Debrecen, H-4032 Debrecen, Hungary.
Regdon Z; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary.; Doctoral School of Molecular Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Robaszkiewicz A; Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Poland.
Tar K; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 05; Vol. 22 (4). Date of Electronic Publication: 2021 Feb 05.
Typ publikacji:
Journal Article
MeSH Terms:
GTP Phosphohydrolases/*genetics
Gene Expression Profiling/*methods
Neuroblastoma/*genetics
Nuclear Proteins/*genetics
RNA, Small Interfering/*pharmacology
Cell Line, Tumor ; Chromatin Immunoprecipitation ; Gene Deletion ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Regulatory Networks ; Glycolysis/drug effects ; Humans ; Mitochondria/drug effects ; Mitochondria/genetics ; Nuclear Proteins/antagonists & inhibitors ; Oligomycins/pharmacology ; Oxidative Phosphorylation/drug effects ; Sequence Analysis, RNA
Czasopismo naukowe
Tytuł:
Green fluorescent protein-based lactate and pyruvate indicators suitable for biochemical assays and live cell imaging.
Autorzy:
Harada K; Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro, Tokyo, 153-8902, Japan.
Chihara T; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-0033, Japan.
Hayasaka Y; Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro, Tokyo, 153-8902, Japan.
Mita M; Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro, Tokyo, 153-8902, Japan.
Takizawa M; Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro, Tokyo, 153-8902, Japan.
Ishida K; Myoridge Co. Ltd., 46-29 Yoshidashimoadachi-cho, Sakyo, Kyoto, 606-8501, Japan.
Arai M; Department of Biology, Faculty of Science, Kyushu University, 774 Motooka, Nishi, Fukuoka, 819-0395, Japan.
Tsuno S; Dairy Science and Technology Institute, Kyodo Milk Industry Co. Ltd., Hinode-machi, Nishitama-gun, Tokyo, 190-0182, Japan.
Matsumoto M; Dairy Science and Technology Institute, Kyodo Milk Industry Co. Ltd., Hinode-machi, Nishitama-gun, Tokyo, 190-0182, Japan.
Ishihara T; Department of Biology, Faculty of Science, Kyushu University, 774 Motooka, Nishi, Fukuoka, 819-0395, Japan.
Ueda H; Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa, 226-8503, Japan.
Kitaguchi T; Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa, 226-8503, Japan. .
Tsuboi T; Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro, Tokyo, 153-8902, Japan. .; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-0033, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2020 Nov 11; Vol. 10 (1), pp. 19562. Date of Electronic Publication: 2020 Nov 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Green Fluorescent Proteins/*metabolism
Lactic Acid/*blood
Recombinant Proteins/*metabolism
Serine/*analysis
Animals ; Biosensing Techniques/methods ; Cells, Cultured ; Female ; Glycolysis ; Green Fluorescent Proteins/genetics ; HeLa Cells ; Humans ; Lactic Acid/metabolism ; Mice, Inbred ICR ; Molecular Imaging/methods ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Neurons/metabolism ; Oligomycins/pharmacology ; Pregnancy ; Pyruvic Acid/metabolism ; Recombinant Proteins/genetics
Czasopismo naukowe
Tytuł:
Homo-Tris-Nitrones Derived from α-Phenyl- N-tert -butylnitrone: Synthesis, Neuroprotection and Antioxidant Properties.
Autorzy:
Diez-Iriepa D; Laboratory of Medicinal Chemistry, Institute of Organic Chemistry (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain.; Department of Organic Chemistry and Inorganic Chemistry, Alcalá University, Alcalá de Henares, 28805 Madrid, Spain.
Chamorro B; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University of Madrid, Plaza Ramón y Cajal s/n, Ciudad Universitaria, 28040 Madrid, Spain.; Faculty of Health, Camilo José Cela University of Madrid (UCJC), 28692 Villafranca del Castillo, Spain.
Talaván M; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University of Madrid, Plaza Ramón y Cajal s/n, Ciudad Universitaria, 28040 Madrid, Spain.
Chioua M; Laboratory of Medicinal Chemistry, Institute of Organic Chemistry (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain.
Iriepa I; Department of Organic Chemistry and Inorganic Chemistry, Alcalá University, Alcalá de Henares, 28805 Madrid, Spain.; Institute of Chemical Research Andrés M. del Río, Alcalá University, Alcalá de Henares, 28805 Madrid, Spain.
Hadjipavlou-Litina D; Department of Pharmaceutical Chemistry, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
López-Muñoz F; Faculty of Health, Camilo José Cela University of Madrid (UCJC), 28692 Villafranca del Castillo, Spain.; Neuropsychopharmacology Unit, 'Hospital 12 de Octubre' Research Institute, 28041 Madrid, Spain.
Marco-Contelles J; Laboratory of Medicinal Chemistry, Institute of Organic Chemistry (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain.
Oset-Gasque MJ; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University of Madrid, Plaza Ramón y Cajal s/n, Ciudad Universitaria, 28040 Madrid, Spain.; Instituto Universitario de Investigación en Neuroquímica, Universidad Complutense de Madrid, 28040 Madrid, Spain.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Oct 26; Vol. 21 (21). Date of Electronic Publication: 2020 Oct 26.
Typ publikacji:
Journal Article
MeSH Terms:
Antioxidants/*chemical synthesis
Cyclic N-Oxides/*chemistry
Neurons/*cytology
Neuroprotective Agents/*chemical synthesis
Nitrogen Oxides/*chemical synthesis
Antioxidants/chemistry ; Antioxidants/pharmacology ; Caspase 3/metabolism ; Cell Line ; Cell Survival/drug effects ; Humans ; Molecular Structure ; Neurons/drug effects ; Neurons/metabolism ; Neuroprotective Agents/chemistry ; Neuroprotective Agents/pharmacology ; Nitrogen Oxides/chemistry ; Nitrogen Oxides/pharmacology ; Oligomycins/adverse effects ; Reactive Oxygen Species/metabolism ; Rotenone/adverse effects
Czasopismo naukowe
Tytuł:
Caspase inhibition rescues F1Fo ATP synthase dysfunction-mediated dendritic spine elimination.
Autorzy:
Chen H; Department of Biological Sciences, The University of Texas at Dallas, 800 west Campbell Rd, Richardson, TX, 75080, USA.
Tian J; Department of Biological Sciences, The University of Texas at Dallas, 800 west Campbell Rd, Richardson, TX, 75080, USA.
Guo L; Department of Biological Sciences, The University of Texas at Dallas, 800 west Campbell Rd, Richardson, TX, 75080, USA.; Higuchi Biosciences Center, The University of Kansas, Lawrence, KS, 66045, USA.
Du H; Department of Biological Sciences, The University of Texas at Dallas, 800 west Campbell Rd, Richardson, TX, 75080, USA. .; Higuchi Biosciences Center, The University of Kansas, Lawrence, KS, 66045, USA. .; Department of Pharmacology & Toxicology, The University of Kansas, Lawrence, KS, 66045, USA. .
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Źródło:
Scientific reports [Sci Rep] 2020 Oct 16; Vol. 10 (1), pp. 17589. Date of Electronic Publication: 2020 Oct 16.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Dendritic Spines/*metabolism
Mitochondria/*metabolism
Mitochondrial Proton-Translocating ATPases/*metabolism
Adenosine Triphosphate/metabolism ; Amino Acid Chloromethyl Ketones/pharmacology ; Animals ; Caspase 3/metabolism ; Caspase Inhibitors/pharmacology ; Cell Death ; Female ; Hippocampus/metabolism ; Male ; Membrane Potential, Mitochondrial ; Mice ; Mice, Inbred C57BL ; Mitochondrial Proton-Translocating ATPases/physiology ; Neurons/metabolism ; Oligomycins/metabolism ; Oligomycins/pharmacology ; Quinolines/pharmacology ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł:
Synthesis, antioxidant properties and neuroprotection of α-phenyl-tert-butylnitrone derived HomoBisNitrones in in vitro and in vivo ischemia models.
Autorzy:
Chamorro B; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University of Madrid, 28040, Madrid, Spain.; Faculty of Health, Camilo José Cela University of Madrid (UCJC), Madrid, Spain.
Diez-Iriepa D; Laboratory of Medicinal Chemistry, Institute of Organic Chemistry (CSIC), Juan de la Cierva 3, 28006, Madrid, Spain.; Department of Organic Chemistry and Inorganic Chemistry, Alcalá University, 28805, Alcalá de Henares, Madrid, Spain.
Merás-Sáiz B; Laboratory of Medicinal Chemistry, Institute of Organic Chemistry (CSIC), Juan de la Cierva 3, 28006, Madrid, Spain.
Chioua M; Laboratory of Medicinal Chemistry, Institute of Organic Chemistry (CSIC), Juan de la Cierva 3, 28006, Madrid, Spain.
García-Vieira D; Laboratory of Medicinal Chemistry, Institute of Organic Chemistry (CSIC), Juan de la Cierva 3, 28006, Madrid, Spain.
Iriepa I; Department of Organic Chemistry and Inorganic Chemistry, Alcalá University, 28805, Alcalá de Henares, Madrid, Spain.; Institute of Chemical Research Andrés M. del Río, Alcalá University, 28805, Alcalá de Henares, Madrid, Spain.
Hadjipavlou-Litina D; Department of Pharmaceutical Chemistry, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece.
López-Muñoz F; Faculty of Health, Camilo José Cela University of Madrid (UCJC), Madrid, Spain.; Neuropsychopharmacology Unit, 'Hospital 12 de Octubre' Research Institute, Madrid, Spain.
Martínez-Murillo R; Neurovascular Research Group, Department of Translational Neurobiology, Cajal Institute (CSIC), Madrid, Spain. .
Gonzàlez-Nieto D; Center for Biomedical Technology (CTB), Universidad Politécnica de Madrid, Madrid, Spain.; Biomedical Research Networking Center in Bioengineering Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain.
Fernández I; Biomedical Research Networking Center in Bioengineering Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain. .; Departamento de Química Orgánica I and Centro de Innovación en Química Avanzada (ORFEO-CINQA), Facultad de Ciencias Químicas, Universidad Complutense de Madrid, 28040, Madrid, Spain. .
Marco-Contelles J; Laboratory of Medicinal Chemistry, Institute of Organic Chemistry (CSIC), Juan de la Cierva 3, 28006, Madrid, Spain. .
Oset-Gasque MJ; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University of Madrid, 28040, Madrid, Spain. .; Instituto Universitario de Investigación en Neuroquímica, Universidad Complutense de Madrid, 28040, Madrid, Spain. .
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Źródło:
Scientific reports [Sci Rep] 2020 Aug 25; Vol. 10 (1), pp. 14150. Date of Electronic Publication: 2020 Aug 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Brain Ischemia/*drug therapy
Cyclic N-Oxides/*chemistry
Free Radical Scavengers/*therapeutic use
Neurons/*drug effects
Neuroprotection/*drug effects
Neuroprotective Agents/*therapeutic use
Nitrogen Oxides/*therapeutic use
Animals ; Apoptosis/drug effects ; Brain Ischemia/chemically induced ; Cell Line, Tumor ; Disease Models, Animal ; Drug Evaluation, Preclinical ; Free Radical Scavengers/chemical synthesis ; Free Radical Scavengers/pharmacology ; Glucose/pharmacology ; Infarction, Middle Cerebral Artery/drug therapy ; Lipid Peroxidation/drug effects ; Lipoxygenase Inhibitors/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Molecular Structure ; Neuroblastoma/pathology ; Neuroprotective Agents/chemical synthesis ; Neuroprotective Agents/pharmacology ; Nitrogen Oxides/chemical synthesis ; Nitrogen Oxides/pharmacology ; Oligomycins/toxicity ; Oxygen/pharmacology ; Rotenone/toxicity
Czasopismo naukowe
Tytuł:
Oligomycins inhibit Magnaporthe oryzae Triticum and suppress wheat blast disease.
Autorzy:
Chakraborty M; Institute of Biotechnology and Genetic Engineering, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur, Bangladesh.
Mahmud NU; Institute of Biotechnology and Genetic Engineering, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur, Bangladesh.
Muzahid ANM; Institute of Biotechnology and Genetic Engineering, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur, Bangladesh.
Rabby SMF; Institute of Biotechnology and Genetic Engineering, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur, Bangladesh.
Islam T; Institute of Biotechnology and Genetic Engineering, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur, Bangladesh.
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Źródło:
PloS one [PLoS One] 2020 Aug 17; Vol. 15 (8), pp. e0233665. Date of Electronic Publication: 2020 Aug 17 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Magnaporthe/*drug effects
Magnaporthe/*pathogenicity
Oligomycins/*pharmacology
Plant Diseases/*microbiology
Plant Diseases/*prevention & control
Triticum/*microbiology
Biological Control Agents/pharmacology ; Edible Grain/microbiology ; Food Microbiology ; Fungicides, Industrial/pharmacology ; Hyphae/drug effects ; Hyphae/growth & development ; Magnaporthe/growth & development ; Mycelium/drug effects ; Mycelium/growth & development ; Spores, Fungal/drug effects ; Spores, Fungal/growth & development
Czasopismo naukowe
Tytuł:
PPARβ/δ-dependent MSC metabolism determines their immunoregulatory properties.
Autorzy:
Contreras-Lopez RA; Centro de Investigación Biomédica, Facultad de Medicina, Universidad de Los Andes, Santiago, Chile.; IRMB, Univ Montpellier, INSERM, CHU Montpellier, Inserm U 1183, IRMB, Hôpital Saint-Eloi, 80 Avenue Augustin Fliche, 34295, Montpellier Cedex 5, France.
Elizondo-Vega R; Facultad de Ciencias Biológicas, Departamento de Biología Celular, Laboratorio de Biología Celular, Universidad de Concepción, Concepción, Chile.
Torres MJ; Escuela de Ingeniería Bioquímica, Pontificia Universidad Católica de Valparaiso, Valparaiso, Chile.
Vega-Letter AM; Cells for Cells, Consorcio Regenero, Las Condes, Santiago, Chile.; Laboratory of Nano-Regenerative Medicine, Facultad de Medicina, Universidad de Los Andes, Santiago, Chile.
Luque-Campos N; Centro de Investigación Biomédica, Facultad de Medicina, Universidad de Los Andes, Santiago, Chile.
Paredes-Martinez MJ; Centro de Investigación Biomédica, Facultad de Medicina, Universidad de Los Andes, Santiago, Chile.
Pradenas C; Centro de Investigación Biomédica, Facultad de Medicina, Universidad de Los Andes, Santiago, Chile.
Tejedor G; IRMB, Univ Montpellier, INSERM, CHU Montpellier, Inserm U 1183, IRMB, Hôpital Saint-Eloi, 80 Avenue Augustin Fliche, 34295, Montpellier Cedex 5, France.
Oyarce K; Facultad de Ciencias de la Salud, Universidad San Sebastián, Concepción, Chile.
Salgado M; Facultad de Ciencias Biológicas, Departamento de Biología Celular, Laboratorio de Biología Celular, Universidad de Concepción, Concepción, Chile.
Jorgensen C; IRMB, Univ Montpellier, INSERM, CHU Montpellier, Inserm U 1183, IRMB, Hôpital Saint-Eloi, 80 Avenue Augustin Fliche, 34295, Montpellier Cedex 5, France.
Khoury M; Cells for Cells, Consorcio Regenero, Las Condes, Santiago, Chile.; Laboratory of Nano-Regenerative Medicine, Facultad de Medicina, Universidad de Los Andes, Santiago, Chile.
Kronke G; Department of Internal Medicine 3, University of Erlangen-Nuremberg, 91054, Erlangen, Germany.
Garcia-Robles MA; Facultad de Ciencias Biológicas, Departamento de Biología Celular, Laboratorio de Biología Celular, Universidad de Concepción, Concepción, Chile.
Altamirano C; Escuela de Ingeniería Bioquímica, Pontificia Universidad Católica de Valparaiso, Valparaiso, Chile.
Luz-Crawford P; Centro de Investigación Biomédica, Facultad de Medicina, Universidad de Los Andes, Santiago, Chile. .
Djouad F; IRMB, Univ Montpellier, INSERM, CHU Montpellier, Inserm U 1183, IRMB, Hôpital Saint-Eloi, 80 Avenue Augustin Fliche, 34295, Montpellier Cedex 5, France. .
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Źródło:
Scientific reports [Sci Rep] 2020 Jul 10; Vol. 10 (1), pp. 11423. Date of Electronic Publication: 2020 Jul 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mesenchymal Stem Cells/*metabolism
PPAR-beta/*metabolism
Receptors, Cytoplasmic and Nuclear/*metabolism
Animals ; Bone Marrow Cells/cytology ; CD4-Positive T-Lymphocytes/cytology ; Cell Proliferation ; Gene Silencing ; Glycolysis ; Immunosuppression Therapy ; Mice ; Oligomycins/chemistry ; Th1 Cells/cytology ; Th17 Cells/cytology
Czasopismo naukowe

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