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Tytuł:: Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.
Autorzy:: Chouchani ET; MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, UK.
Pell VR; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, UK.
Gaude E; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Box 197, Cambridge Biomedical Campus, Cambridge, CB2 0XZ, UK.
Aksentijević D; King's College London, British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas' Hospital, London SE1 7EH, UK.
Sundier SY; Department of Cell and Developmental Biology and UCL Consortium for Mitochondrial Biology, University College London, Gower Street, London WC1E 6BT, UK.
Robb EL; MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.
Logan A; MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.
Nadtochiy SM; Department of Anesthesiology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA.
Ord ENJ; Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK.
Smith AC; MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.
Eyassu F; MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.
Shirley R; Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK.
Hu CH; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, UK.
Dare AJ; MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.
James AM; MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.
Rogatti S; MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.
Hartley RC; School of Chemistry, University of Glasgow, Glasgow, G12 8TA, UK.
Eaton S; Unit of Paediatric Surgery, UCL Institute of Child Health, London, WC1N 1EH, UK.
Costa ASH; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Box 197, Cambridge Biomedical Campus, Cambridge, CB2 0XZ, UK.
Brookes PS; Department of Anesthesiology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA.
Davidson SM; Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, London, WC1E 6HX, UK.
Duchen MR; Department of Cell and Developmental Biology and UCL Consortium for Mitochondrial Biology, University College London, Gower Street, London WC1E 6BT, UK.
Saeb-Parsy K; University Department of Surgery and Cambridge NIHR Biomedical Research Centre, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
Shattock MJ; King's College London, British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas' Hospital, London SE1 7EH, UK.
Robinson AJ; MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.
Work LM; Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK.
Frezza C; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Box 197, Cambridge Biomedical Campus, Cambridge, CB2 0XZ, UK.
Krieg T; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, UK.
Murphy MP; MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.; Pokaż więcej
Źródło:: Nature [Nature] 2014 Nov 20; Vol. 515 (7527), pp. 431-435. Date of Electronic Publication: 2014 Nov 05.
Typ publikacji:: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Ischemia/*metabolism
Mitochondria/*metabolism
Reactive Oxygen Species/*metabolism
Reperfusion Injury/*metabolism
Succinic Acid/*metabolism
Adenosine Monophosphate/metabolism ; Animals ; Aspartic Acid/metabolism ; Citric Acid Cycle ; Disease Models, Animal ; Electron Transport ; Electron Transport Complex I/metabolism ; Fumarates/metabolism ; Ischemia/enzymology ; Malates/metabolism ; Male ; Metabolomics ; Mice ; Mitochondria/enzymology ; Myocardial Infarction/enzymology ; Myocardial Infarction/metabolism ; Myocardium/cytology ; Myocardium/enzymology ; Myocardium/metabolism ; Myocytes, Cardiac/enzymology ; Myocytes, Cardiac/metabolism ; NAD/metabolism ; Reperfusion Injury/enzymology ; Stroke/enzymology ; Stroke/metabolism ; Succinate Dehydrogenase/metabolism

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