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Tytuł :
Extracellular hyaluronate pressure shaped by cellular tethers drives tissue morphogenesis.
Autorzy :
Munjal A; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: .
Hannezo E; Institute of Science and Technology, Am Campus 1, 3400 Klosterneuburg, Austria.
Tsai TY; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
Mitchison TJ; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
Megason SG; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: .
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Źródło :
Cell [Cell] 2021 Dec 22; Vol. 184 (26), pp. 6313-6325.e18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Morphogenesis*/drug effects
Organ Specificity*/drug effects
Pressure*
Extracellular Space/*chemistry
Hyaluronic Acid/*pharmacology
Semicircular Canals/*cytology
Semicircular Canals/*embryology
Actomyosin/metabolism ; Animals ; Anisotropy ; Behavior, Animal ; Extracellular Matrix/metabolism ; Hyaluronic Acid/biosynthesis ; Models, Biological ; Osmotic Pressure ; Semicircular Canals/diagnostic imaging ; Stereotyped Behavior ; Zebrafish/embryology ; Zebrafish Proteins/metabolism
Czasopismo naukowe
Tytuł :
Differential Dose- and Tissue-Dependent Effects of foxo on Aging, Metabolic and Proteostatic Pathways.
Autorzy :
Manola MS; Department of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, Panepistimiopolis, 15784 Athens, Greece.
Gumeni S; Department of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, Panepistimiopolis, 15784 Athens, Greece.
Trougakos IP; Department of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, Panepistimiopolis, 15784 Athens, Greece.
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Źródło :
Cells [Cells] 2021 Dec 18; Vol. 10 (12). Date of Electronic Publication: 2021 Dec 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Organ Specificity*
Proteostasis*
Aging/*metabolism
Drosophila Proteins/*metabolism
Drosophila melanogaster/*metabolism
Forkhead Transcription Factors/*metabolism
Animals ; Animals, Genetically Modified ; Energy Metabolism ; Heat-Shock Response ; Metabolic Networks and Pathways ; Muscles/metabolism ; Myocytes, Cardiac/metabolism ; Nutrients ; Oxidative Stress ; Phenotype ; Proteasome Endopeptidase Complex/metabolism ; Proteome/metabolism
Czasopismo naukowe
Tytuł :
Mitochondrial Bioenergetic and Proteomic Phenotyping Reveals Organ-Specific Consequences of Chronic Kidney Disease in Mice.
Autorzy :
Thome T; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA.
Coleman MD; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA.
Ryan TE; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA.; Center for Exercise Science, University of Florida, Gainesville, FL 32611, USA.; Myology Institute, University of Florida, Gainesville, FL 32611, USA.
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Źródło :
Cells [Cells] 2021 Nov 24; Vol. 10 (12). Date of Electronic Publication: 2021 Nov 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Energy Metabolism*
Organ Specificity*
Proteomics*
Mitochondria/*metabolism
Renal Insufficiency, Chronic/*metabolism
Adenine/administration & dosage ; Animals ; Electron Transport ; Feeding Behavior ; Hydrogen Peroxide/metabolism ; Kidney/pathology ; Male ; Membrane Potential, Mitochondrial ; Mice, Inbred C57BL ; Mitochondria/enzymology ; Mitochondrial Proteins/metabolism ; NAD/metabolism ; Oxidation-Reduction ; Phenotype ; Proteome/metabolism
Czasopismo naukowe
Tytuł :
The Role of Fibroblast Growth Factor (FGF) Signaling in Tissue Repair and Regeneration.
Autorzy :
Farooq M; Department of Molecular Science and Technology, Ajou University, Suwon 16499, Korea.
Khan AW; Department of Molecular Science and Technology, Ajou University, Suwon 16499, Korea.
Kim MS; Department of Molecular Science and Technology, Ajou University, Suwon 16499, Korea.
Choi S; Department of Molecular Science and Technology, Ajou University, Suwon 16499, Korea.; S&K Therapeutics, Ajou University Campus Plaza 418, 199 Worldcup-ro, Yeongtong-gu, Suwon 16502, Korea.
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Źródło :
Cells [Cells] 2021 Nov 19; Vol. 10 (11). Date of Electronic Publication: 2021 Nov 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Organ Specificity*
Regeneration*
Signal Transduction*
Fibroblast Growth Factors/*metabolism
Animals ; Humans ; Models, Biological ; Receptors, Fibroblast Growth Factor/metabolism
Czasopismo naukowe
Tytuł :
Multi-Tissue Characterization of GILZ Expression in Dendritic Cell Subsets at Steady State and in Inflammatory Contexts.
Autorzy :
Docq M; Inserm U996, Inflammation, Microbiome and Immunosurveillance, Université Paris-Saclay, 92140 Clamart, France.
Vétillard M; Inserm U996, Inflammation, Microbiome and Immunosurveillance, Université Paris-Saclay, 92140 Clamart, France.
Gallego C; Inserm U996, Inflammation, Microbiome and Immunosurveillance, Université Paris-Saclay, 92140 Clamart, France.
Jaracz-Ros A; Inserm U996, Inflammation, Microbiome and Immunosurveillance, Université Paris-Saclay, 92140 Clamart, France.
Mercier-Nomé F; Inserm U996, Inflammation, Microbiome and Immunosurveillance, Université Paris-Saclay, 92140 Clamart, France.; IPSIT SFR-UMS, CNRS, Inserm, Institut Paris Saclay d'Innovation Thérapeutique, Université Paris-Saclay, 92296 Chatenay-Malabry, France.
Bachelerie F; Inserm U996, Inflammation, Microbiome and Immunosurveillance, Université Paris-Saclay, 92140 Clamart, France.
Schlecht-Louf G; Inserm U996, Inflammation, Microbiome and Immunosurveillance, Université Paris-Saclay, 92140 Clamart, France.
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Źródło :
Cells [Cells] 2021 Nov 13; Vol. 10 (11). Date of Electronic Publication: 2021 Nov 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Organ Specificity*
Dendritic Cells/*pathology
Inflammation/*pathology
Transcription Factors/*metabolism
Acute Disease ; Animals ; Biomarkers/metabolism ; Cell Line, Tumor ; Cell Movement ; Chronic Disease ; Langerhans Cells/pathology ; Lymph Nodes/metabolism ; Mice, Inbred C57BL ; Mice, Transgenic ; Neoplasms/pathology ; Skin/pathology
Czasopismo naukowe
Tytuł :
Enteric pathogens induce tissue tolerance and prevent neuronal loss from subsequent infections.
Autorzy :
Ahrends T; Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY, USA. Electronic address: .
Aydin B; Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY, USA.
Matheis F; Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY, USA.
Classon CH; Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY, USA.
Marchildon F; Laboratory of Molecular Metabolism, The Rockefeller University, New York, NY, USA.
Furtado GC; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Lira SA; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mucida D; Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY, USA; Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA. Electronic address: .
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Źródło :
Cell [Cell] 2021 Nov 11; Vol. 184 (23), pp. 5715-5727.e12. Date of Electronic Publication: 2021 Oct 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Neuroprotection*
Organ Specificity*
Enteric Nervous System/*microbiology
Enteric Nervous System/*parasitology
Infections/*microbiology
Infections/*parasitology
Neurons/*pathology
Yersinia pseudotuberculosis/*physiology
Animals ; Eosinophils/metabolism ; Hematopoietic Stem Cells/metabolism ; Immunity ; Infections/immunology ; Interleukin-13/metabolism ; Interleukin-4/metabolism ; Macrophages/metabolism ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Strongyloides/physiology ; Strongyloidiasis/genetics ; Strongyloidiasis/immunology ; Strongyloidiasis/parasitology ; Transcriptome/genetics ; Yersinia pseudotuberculosis Infections/genetics ; Yersinia pseudotuberculosis Infections/immunology ; Yersinia pseudotuberculosis Infections/microbiology
Czasopismo naukowe
Tytuł :
A Microbiome-Derived Peptide Induces Apoptosis of Cells from Different Tissues.
Autorzy :
Saiki H; Department of Pulmonary and Critical Care Medicine, Faculty and Graduate School of Medicine, Mie University, Tsu 514-8507, Mie, Japan.
Okano Y; Department of Immunology, Faculty and Graduate School of Medicine, Mie University, Tsu 514-8507, Mie, Japan.; Department of Diabetes, Endocrinology and Metabolism, Faculty and Graduate School of Medicine, Mie University, Tsu 514-8507, Mie, Japan.
Yasuma T; Department of Immunology, Faculty and Graduate School of Medicine, Mie University, Tsu 514-8507, Mie, Japan.; Department of Diabetes, Endocrinology and Metabolism, Faculty and Graduate School of Medicine, Mie University, Tsu 514-8507, Mie, Japan.
Toda M; Department of Immunology, Faculty and Graduate School of Medicine, Mie University, Tsu 514-8507, Mie, Japan.
Takeshita A; Department of Immunology, Faculty and Graduate School of Medicine, Mie University, Tsu 514-8507, Mie, Japan.; Department of Diabetes, Endocrinology and Metabolism, Faculty and Graduate School of Medicine, Mie University, Tsu 514-8507, Mie, Japan.
Abdel-Hamid AM; Department of Botany and Microbiology, Faculty of Science, Minia University, El-Minia 61519, Egypt.; Carl R. Woese Institute for Genomic Biology (Microbiome Metabolic Engineering), University of Illinois at Urbana-Champaign, Urbana, IL 61801-3633, USA.
Fridman D'Alessandro V; Department of Immunology, Faculty and Graduate School of Medicine, Mie University, Tsu 514-8507, Mie, Japan.
Tsuruga T; Department of Pulmonary and Critical Care Medicine, Faculty and Graduate School of Medicine, Mie University, Tsu 514-8507, Mie, Japan.
D'Alessandro-Gabazza CN; Department of Immunology, Faculty and Graduate School of Medicine, Mie University, Tsu 514-8507, Mie, Japan.
Katayama K; Department of Cardiology and Nephrology, Faculty and Graduate School of Medicine, Mie University, Tsu 514-8507, Mie, Japan.
Sugimoto M; Department of Ophthalmology, Faculty and Graduate School of Medicine, Mie University, Tsu 514-8507, Mie, Japan.
Fujimoto H; Department of Pulmonary and Critical Care Medicine, Faculty and Graduate School of Medicine, Mie University, Tsu 514-8507, Mie, Japan.
Yamanaka K; Department of Dermatology, Faculty and Graduate School of Medicine, Mie University, Tsu 514-8507, Mie, Japan.
Kobayashi T; Department of Pulmonary and Critical Care Medicine, Faculty and Graduate School of Medicine, Mie University, Tsu 514-8507, Mie, Japan.
Cann I; Carl R. Woese Institute for Genomic Biology (Microbiome Metabolic Engineering), University of Illinois at Urbana-Champaign, Urbana, IL 61801-3633, USA.; Departments of Animal Science, and Microbiology, The University of Illinois at Urbana-Champaign, Urbana, IL 61801-3633, USA.
Gabazza EC; Department of Immunology, Faculty and Graduate School of Medicine, Mie University, Tsu 514-8507, Mie, Japan.; Carl R. Woese Institute for Genomic Biology (Microbiome Metabolic Engineering), University of Illinois at Urbana-Champaign, Urbana, IL 61801-3633, USA.
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Źródło :
Cells [Cells] 2021 Oct 26; Vol. 10 (11). Date of Electronic Publication: 2021 Oct 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*/drug effects
Microbiota*/drug effects
Organ Specificity*/drug effects
Peptides/*pharmacology
Caspase 3/metabolism ; Cell Line, Tumor ; Epithelial Cells/drug effects ; Epithelial Cells/pathology ; HaCaT Cells ; Humans ; Keratinocytes/drug effects ; Keratinocytes/pathology ; Mitochondrial Membranes/drug effects ; Mitochondrial Membranes/metabolism ; Podocytes/drug effects ; Podocytes/pathology ; Reactive Oxygen Species/metabolism ; Retina/pathology ; Transforming Growth Factor beta1/metabolism
Czasopismo naukowe
Tytuł :
Does exercise during pregnancy impact organs or structures of the maternal-fetal interface?
Autorzy :
Bhattacharjee J; School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, Canada.
Mohammad S; School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, Canada.
Adamo KB; School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, Canada. Electronic address: .
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Źródło :
Tissue & cell [Tissue Cell] 2021 Oct; Vol. 72, pp. 101543. Date of Electronic Publication: 2021 Apr 16.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Organ Specificity*
Exercise/*physiology
Maternal-Fetal Exchange/*physiology
Endocrine System/metabolism ; Female ; Humans ; Pregnancy ; Regional Blood Flow/physiology
Czasopismo naukowe
Tytuł :
Artificial Intelligence and Cellular Segmentation in Tissue Microscopy Images.
Autorzy :
Durkee MS; Department of Radiology and the Committee on Medical Physics, University of Chicago, Chicago, Illinois. Electronic address: .
Abraham R; Department of Medicine, Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, Illinois.
Clark MR; Department of Medicine, Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, Illinois.
Giger ML; Department of Radiology and the Committee on Medical Physics, University of Chicago, Chicago, Illinois. Electronic address: .
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Źródło :
The American journal of pathology [Am J Pathol] 2021 Oct; Vol. 191 (10), pp. 1693-1701. Date of Electronic Publication: 2021 Jun 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms :
Artificial Intelligence*
Image Processing, Computer-Assisted*
Microscopy*
Organ Specificity*
Cells/*cytology
Animals ; Deep Learning ; Humans
Czasopismo naukowe
Tytuł :
Comparative analysis of transcriptomic profiles among ascidians, zebrafish, and mice: Insights from tissue-specific gene expression.
Autorzy :
Matsubara S; Bioorganic Research Institute, Suntory Foundation for Life Sciences, Kyoto, Japan.
Osugi T; Bioorganic Research Institute, Suntory Foundation for Life Sciences, Kyoto, Japan.
Shiraishi A; Bioorganic Research Institute, Suntory Foundation for Life Sciences, Kyoto, Japan.
Wada A; Bioorganic Research Institute, Suntory Foundation for Life Sciences, Kyoto, Japan.
Satake H; Bioorganic Research Institute, Suntory Foundation for Life Sciences, Kyoto, Japan.
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Źródło :
PloS one [PLoS One] 2021 Sep 24; Vol. 16 (9), pp. e0254308. Date of Electronic Publication: 2021 Sep 24 (Print Publication: 2021).
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biological Evolution*
Gene Expression Regulation*
Gene Regulatory Networks*
Organ Specificity*
Transcriptome*
Ciona intestinalis/*genetics
Zebrafish/*genetics
Animals ; Female ; Mice
Czasopismo naukowe
Tytuł :
A Comparative Study of the Effect of Anatomical Site on Multiple Differentiation of Adipose-Derived Stem Cells in Rats.
Autorzy :
Hendawy H; Laboratory of Veterinary Surgery, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan.; Department of Veterinary Surgery, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt.
Kaneda M; Laboratory of Veterinary Anatomy, Division of Animal Life Science, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan.
Metwally E; Department of Cytology and Histology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt.
Shimada K; Laboratory of Veterinary Surgery, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan.
Tanaka T; Laboratory of Veterinary Surgery, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan.
Tanaka R; Laboratory of Veterinary Surgery, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan.
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Źródło :
Cells [Cells] 2021 Sep 18; Vol. 10 (9). Date of Electronic Publication: 2021 Sep 18.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Differentiation*
Organ Specificity*
Adipocytes/*cytology
Chondrocytes/*cytology
Mesenchymal Stem Cells/*cytology
Osteoblasts/*cytology
Adipocytes/metabolism ; Animals ; Cell Proliferation ; Cells, Cultured ; Chondrocytes/metabolism ; Female ; Immunophenotyping ; Mesenchymal Stem Cells/metabolism ; Osteoblasts/metabolism ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
A Novel UPLC-MS/MS Method Identifies Organ-Specific Dipeptide Profiles.
Autorzy :
Heidenreich E; Centre for Organismal Studies (COS), Metabolomics Core Technology Platform, Heidelberg University, 69120 Heidelberg, Germany.
Pfeffer T; Centre for Paediatric and Adolescent Medicine, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Kracke T; Centre for Paediatric and Adolescent Medicine, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Mechtel N; Centre for Organismal Studies (COS), Metabolomics Core Technology Platform, Heidelberg University, 69120 Heidelberg, Germany.
Nawroth P; Department of Internal Medicine I and Clinical Chemistry, University Hospital of Heidelberg, 69120 Heidelberg, Germany.; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.; Institute for Diabetes and Cancer (IDC) Helmholtz Center Munich, 85764 Neuherberg, Germany.; Joint Heidelberg-Institute for Diabetes and Cancer (IDC) Translational Diabetes Program, 85764 Neuherberg, Germany.
Hoffmann GF; Centre for Paediatric and Adolescent Medicine, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Schmitt CP; Centre for Paediatric and Adolescent Medicine, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Hell R; Centre for Organismal Studies (COS), Metabolomics Core Technology Platform, Heidelberg University, 69120 Heidelberg, Germany.
Poschet G; Centre for Organismal Studies (COS), Metabolomics Core Technology Platform, Heidelberg University, 69120 Heidelberg, Germany.
Peters V; Centre for Paediatric and Adolescent Medicine, University Hospital Heidelberg, 69120 Heidelberg, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 15; Vol. 22 (18). Date of Electronic Publication: 2021 Sep 15.
Typ publikacji :
Journal Article
MeSH Terms :
Organ Specificity*
Tandem Mass Spectrometry*
Dipeptides/*analysis
Amino Acids/analysis ; Animals ; Body Fluids/metabolism ; Chromatography, High Pressure Liquid ; Dipeptides/chemistry ; Mice, Inbred C57BL ; Reference Standards ; Reproducibility of Results ; Stereoisomerism
Czasopismo naukowe
Tytuł :
Chromosomal neighbourhoods allow identification of organ specific changes in gene expression.
Autorzy :
Das Roy R; Institute of Biotechnology, University of Helsinki, Helsinki, Finland.
Hallikas O; Institute of Biotechnology, University of Helsinki, Helsinki, Finland.
Christensen MM; Institute of Biotechnology, University of Helsinki, Helsinki, Finland.
Renvoisé E; Institute of Biotechnology, University of Helsinki, Helsinki, Finland.
Jernvall J; Institute of Biotechnology, University of Helsinki, Helsinki, Finland.; Department of Geosciences and Geography, University of Helsinki, Helsinki, Finland.
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Źródło :
PLoS computational biology [PLoS Comput Biol] 2021 Sep 10; Vol. 17 (9), pp. e1008947. Date of Electronic Publication: 2021 Sep 10 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromosomes*
Organ Specificity*
Gene Expression Profiling/*methods
Animals ; Gene Ontology ; Mice ; Proteins/genetics
Czasopismo naukowe
Tytuł :
A body map of somatic mutagenesis in morphologically normal human tissues.
Autorzy :
Li R; Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University (PKU), Beijing, China.; Beijing Advanced Innovation Center for Genomics (ICG), Peking University, Beijing, China.
Di L; Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University (PKU), Beijing, China.; Beijing Advanced Innovation Center for Genomics (ICG), Peking University, Beijing, China.
Li J; School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China.; Beijing Advanced Innovation Center for Structural Biology (ICSB), Tsinghua University, Beijing, China.
Fan W; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China.
Liu Y; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China.
Guo W; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China.
Liu W; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China.
Liu L; Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University (PKU), Beijing, China.; Beijing Advanced Innovation Center for Genomics (ICG), Peking University, Beijing, China.
Li Q; School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China.; Beijing Advanced Innovation Center for Structural Biology (ICSB), Tsinghua University, Beijing, China.
Chen L; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China.
Chen Y; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China.
Miao C; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China.
Liu H; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China.
Wang Y; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China.
Ma Y; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China.
Xu D; Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University (PKU), Beijing, China.; Beijing Advanced Innovation Center for Genomics (ICG), Peking University, Beijing, China.
Lin D; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China. .; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China. .; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangzhou, China. .; CAMS Key Laboratory of Cancer Genomic Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. .
Huang Y; Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University (PKU), Beijing, China. .; Beijing Advanced Innovation Center for Genomics (ICG), Peking University, Beijing, China. .; College of Chemistry and Molecular Engineering, Beijing National Laboratory for Molecular Sciences, Peking University, Beijing, China. .; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China. .; Institute for Cell Analysis, Shenzhen Bay Laboratory, Guangdong, China. .
Wang J; School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China. .; Beijing Advanced Innovation Center for Structural Biology (ICSB), Tsinghua University, Beijing, China. .
Bai F; Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University (PKU), Beijing, China. .; Beijing Advanced Innovation Center for Genomics (ICG), Peking University, Beijing, China. .; Center for Translational Cancer Research, Peking University First Hospital, Beijing, China. .
Wu C; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China. .; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China. .; CAMS Key Laboratory of Cancer Genomic Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. .; CAMS Oxford Institute (COI), CAMS, Beijing, China. .
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Źródło :
Nature [Nature] 2021 Sep; Vol. 597 (7876), pp. 398-403. Date of Electronic Publication: 2021 Aug 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Health*
Mutagenesis*
Mutation*
Organ Specificity*
Clone Cells/*metabolism
Aged, 80 and over ; Biopsy ; Cadaver ; Cardia/metabolism ; Cell Proliferation ; Clone Cells/cytology ; Esophagus/metabolism ; Female ; Genomics ; Humans ; Male
Czasopismo naukowe
Tytuł :
Short-term cell death in tissues of Pulsatilla vernalis seeds from natural and ex situ conserved populations.
Autorzy :
Zielińska KM; Department of Geobotany and Plant Ecology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha Str. 12/16, 90-237, Lodz, Poland. .
Kaźmierczak A; Department of Cytophysiology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha Str. 12/16, 90-237, Lodz, Poland.
Michalska E; Department of Geobotany and Plant Ecology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha Str. 12/16, 90-237, Lodz, Poland.
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Źródło :
Scientific reports [Sci Rep] 2021 Aug 19; Vol. 11 (1), pp. 16840. Date of Electronic Publication: 2021 Aug 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Organ Specificity*
Pulsatilla/*cytology
Seeds/*cytology
Cell Death ; Endosperm/cytology ; Principal Component Analysis ; Pulsatilla/embryology
Czasopismo naukowe
Tytuł :
Tabulation of organ dose conversion factors for terrestrial radioactivity monitoring program.
Autorzy :
Sanusi MSM; Department of Physics, Faculty of Science, Universiti Teknologi Malaysia, 81310, Skudai, Joho Bahru, Johor, Malaysia. Electronic address: .
Hassan WMSW; Department of Physics, Faculty of Science, Universiti Teknologi Malaysia, 81310, Skudai, Joho Bahru, Johor, Malaysia.
Hashim S; Department of Physics, Faculty of Science, Universiti Teknologi Malaysia, 81310, Skudai, Joho Bahru, Johor, Malaysia.
Ramli AT; Department of Physics, Faculty of Science, Universiti Teknologi Malaysia, 81310, Skudai, Joho Bahru, Johor, Malaysia.
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Źródło :
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine [Appl Radiat Isot] 2021 Aug; Vol. 174, pp. 109791. Date of Electronic Publication: 2021 May 25.
Typ publikacji :
Journal Article
MeSH Terms :
Organ Specificity*
Radiation Monitoring/*methods
Soil Pollutants, Radioactive/*pharmacokinetics
Gamma Rays ; Humans ; Monte Carlo Method ; Phantoms, Imaging ; Photons
Czasopismo naukowe
Tytuł :
An aged immune system drives senescence and ageing of solid organs.
Autorzy :
Yousefzadeh MJ; Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA.; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Flores RR; Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA.; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Zhu Y; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Schmiechen ZC; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.
Brooks RW; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USA.
Trussoni CE; Division of Gastroenterology, Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, MN, USA.
Cui Y; Department of Chemistry, University of California Riverside, Riverside, CA, USA.
Angelini L; Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA.; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Lee KA; Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA.; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
McGowan SJ; Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA.; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Burrack AL; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.
Wang D; Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Dong Q; Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Lu A; Department of Orthopedic Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Sano T; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USA.
O'Kelly RD; Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA.; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
McGuckian CA; Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA.; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Kato JI; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USA.
Bank MP; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USA.
Wade EA; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USA.
Pillai SPS; Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Klug J; Department of Comparative Medicine, University of Washington, Seattle, WA, USA.
Ladiges WC; Department of Comparative Medicine, University of Washington, Seattle, WA, USA.
Burd CE; Departments of Molecular Genetics and Cancer Biology and Genetics, The Ohio State University, Columbus, OH, USA.
Lewis SE; Department of Physiology & Pharmacology, West Virginia University, Morgantown, WV, USA.
LaRusso NF; Division of Gastroenterology, Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, MN, USA.
Vo NV; Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Wang Y; Department of Chemistry, University of California Riverside, Riverside, CA, USA.
Kelley EE; Department of Physiology & Pharmacology, West Virginia University, Morgantown, WV, USA.
Huard J; Department of Orthopedic Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Stromnes IM; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.
Robbins PD; Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA. .; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA. .
Niedernhofer LJ; Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA. .; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA. .
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Źródło :
Nature [Nature] 2021 Jun; Vol. 594 (7861), pp. 100-105. Date of Electronic Publication: 2021 May 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Aging/*immunology
Aging/*physiology
Immune System/*immunology
Immune System/*physiology
Immunosenescence/*immunology
Immunosenescence/*physiology
Organ Specificity/*immunology
Organ Specificity/*physiology
Aging/drug effects ; Aging/pathology ; Animals ; DNA Damage/immunology ; DNA Damage/physiology ; DNA Repair/immunology ; DNA Repair/physiology ; DNA-Binding Proteins/genetics ; Endonucleases/genetics ; Female ; Healthy Aging/immunology ; Healthy Aging/physiology ; Homeostasis/immunology ; Homeostasis/physiology ; Immune System/drug effects ; Immunosenescence/drug effects ; Male ; Mice ; Organ Specificity/drug effects ; Rejuvenation ; Sirolimus/pharmacology ; Spleen/cytology ; Spleen/transplantation
Czasopismo naukowe
Tytuł :
An atlas of protein-protein interactions across mouse tissues.
Autorzy :
Skinnider MA; Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Scott NE; Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Peter Doherty Institute, Department of Microbiology and Immunology, The University of Melbourne, Melbourne, VIC 3000, Australia.
Prudova A; Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Kerr CH; Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Department of Biochemistry & Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Stoynov N; Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Stacey RG; Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Chan QWT; Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Rattray D; Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Department of Biochemistry & Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Gsponer J; Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Department of Biochemistry & Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address: .
Foster LJ; Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Department of Biochemistry & Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address: .
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Źródło :
Cell [Cell] 2021 Jul 22; Vol. 184 (15), pp. 4073-4089.e17. Date of Electronic Publication: 2021 Jul 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Organ Specificity*
Protein Interaction Mapping*
Animals ; Isotope Labeling ; Male ; Mammals ; Mice, Inbred C57BL ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
Unusual visual and olfactory perceptions during radiotherapy sessions: an investigation of the organs responsible.
Autorzy :
Hara N; Department of Radiology, Juntendo University Hospital, Tokyo 113-8431, Japan.
Isobe A; Department of Radiology, Juntendo University Hospital, Tokyo 113-8431, Japan.
Yamada K; Department of Radiation Oncology, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Kosugi Y; Department of Radiation Oncology, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Oshima M; Department of Radiation Oncology, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Kawamoto T; Department of Radiation Oncology, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Shikama N; Department of Radiation Oncology, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Sasai K; Department of Radiation Oncology, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
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Źródło :
Journal of radiation research [J Radiat Res] 2021 Jul 10; Vol. 62 (4), pp. 718-725.
Typ publikacji :
Journal Article
MeSH Terms :
Organ Specificity*
Radiotherapy*
Olfactory Perception/*physiology
Visual Perception/*physiology
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Radiometry ; Young Adult
Czasopismo naukowe
Tytuł :
Fucoxanthin alters the apelin-13/APJ pathway in certain organs of γ-irradiated mice.
Autorzy :
El Bakary NM; Radiation Biology Department, National Centre for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority, Cairo, Egypt.
Thabet NM; Radiation Biology Department, National Centre for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority, Cairo, Egypt.
El Fatih NM; Radiation Biology Department, National Centre for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority, Cairo, Egypt.
Abdel-Rafei MK; Radiation Biology Department, National Centre for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority, Cairo, Egypt.
El Tawill G; Radiation Biology Department, National Centre for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority, Cairo, Egypt.
Azab KS; Radiation Biology Department, National Centre for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority, Cairo, Egypt.
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Źródło :
Journal of radiation research [J Radiat Res] 2021 Jul 10; Vol. 62 (4), pp. 600-617.
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*/drug effects
Whole-Body Irradiation*
Intercellular Signaling Peptides and Proteins/*metabolism
Organ Specificity/*radiation effects
Xanthophylls/*pharmacology
Animals ; Antioxidants/metabolism ; Apelin Receptors/metabolism ; Gamma Rays ; Inflammation/pathology ; Kidney/drug effects ; Kidney/pathology ; Kidney/radiation effects ; L-Lactate Dehydrogenase/metabolism ; Liver/drug effects ; Liver/pathology ; Liver/radiation effects ; Matrix Metalloproteinase 2/metabolism ; Matrix Metalloproteinase 9/metabolism ; Mice ; NF-kappa B/metabolism ; Organ Specificity/drug effects ; Oxidants/metabolism ; Tissue Inhibitor of Metalloproteinase-1/metabolism
Czasopismo naukowe

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