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Tytuł :
Minutes-timescale 3D isotropic imaging of entire organs at subcellular resolution by content-aware compressed-sensing light-sheet microscopy.
Autorzy :
Fang C; School of Optical and Electronic Information- Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, 430074, Wuhan, China.
Yu T; Britton Chance center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, 430074, Wuhan, China.; MoE Key Laboratory for Biomedical Photonics, Huazhong University of Science and Technology, 430074, Wuhan, China.
Chu T; School of Optical and Electronic Information- Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, 430074, Wuhan, China.
Feng W; School of Optical and Electronic Information- Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, 430074, Wuhan, China.
Zhao F; School of Optical and Electronic Information- Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, 430074, Wuhan, China.
Wang X; School of Optical and Electronic Information- Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, 430074, Wuhan, China.
Huang Y; Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China.
Li Y; Britton Chance center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, 430074, Wuhan, China.
Wan P; Britton Chance center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, 430074, Wuhan, China.
Mei W; Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China. .
Zhu D; Britton Chance center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, 430074, Wuhan, China. .; MoE Key Laboratory for Biomedical Photonics, Huazhong University of Science and Technology, 430074, Wuhan, China. .
Fei P; School of Optical and Electronic Information- Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, 430074, Wuhan, China. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 04; Vol. 12 (1), pp. 107. Date of Electronic Publication: 2021 Jan 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Imaging, Three-Dimensional*
Organ Specificity*
Microscopy, Fluorescence/*methods
Animals ; Brain/diagnostic imaging ; Brain Mapping ; Cell Count ; Green Fluorescent Proteins/metabolism ; Mice ; Muscles/diagnostic imaging ; Neuromuscular Junction/diagnostic imaging ; Neurons/metabolism ; Subcellular Fractions
Czasopismo naukowe
Tytuł :
Novel organ-specific effects of Ketoprofen and its enantiomer, dexketoprofen on toxicological response transcripts and their functional products in salmon.
Autorzy :
Mennillo E; Department of Biology, Norwegian University of Science and Technology (NTNU), Norway; Department of Veterinary Science, University of Pisa, San Piero a Grado (PI), 56122, Italy; Laboratory of Environmental Toxicology, Department of Pharmacology, University of California, San Diego, La Jolla, CA, United States.
Pretti C; Department of Veterinary Science, University of Pisa, San Piero a Grado (PI), 56122, Italy; Interuniversity Center of Marine Biology (CIBM) 'G. Bacci', Leghorn, 57128, Italy.
Cappelli F; Department of Biology, Norwegian University of Science and Technology (NTNU), Norway.
Luci G; Department of Biology, Norwegian University of Science and Technology (NTNU), Norway; Department of Veterinary Science, University of Pisa, San Piero a Grado (PI), 56122, Italy.
Intorre L; Department of Veterinary Science, University of Pisa, San Piero a Grado (PI), 56122, Italy.
Meucci V; Department of Veterinary Science, University of Pisa, San Piero a Grado (PI), 56122, Italy.
Arukwe A; Department of Biology, Norwegian University of Science and Technology (NTNU), Norway. Electronic address: .
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Źródło :
Aquatic toxicology (Amsterdam, Netherlands) [Aquat Toxicol] 2020 Dec; Vol. 229, pp. 105677. Date of Electronic Publication: 2020 Nov 05.
Typ publikacji :
Journal Article
MeSH Terms :
Ketoprofen/*analogs & derivatives
Ketoprofen/*chemistry
Ketoprofen/*toxicity
Organ Specificity/*genetics
Salmo salar/*genetics
Tromethamine/*toxicity
Animals ; Antioxidants/pharmacology ; Biomarkers/metabolism ; Biotransformation/drug effects ; Gills/drug effects ; Gills/metabolism ; Ketoprofen/pharmacology ; Liver/drug effects ; Liver/metabolism ; Organ Specificity/drug effects ; Oxidative Stress/drug effects ; Principal Component Analysis ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Stereoisomerism ; Transcription, Genetic/drug effects ; Water Pollutants, Chemical/toxicity
Czasopismo naukowe
Tytuł :
Tissue expression of antigens of ABH blood groups in species of New World Monkeys (Aotus infulatus, Callithrix jacchus, Sapajus apella and Saimiri sciureus).
Autorzy :
Aguiar DCF; Laboratory of Biomolecular Technology, Institute of Biological Sciences, Federal -University of Pará, Belém, Pará, Brazil.
Pereira WLA; Pathology Laboratory, Rural Federal University of Amazonia, Belém, Pará, Brazil.
de Matos GCB; Institute of Health and Animal Production, Veterinary Medicine Course, Rural Federal University of Amazonia, Belém, Pará, Brazil.
Marruaz da Silva KS; Institute of Science and Technology in Biomodels, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil.
de Loiola RDSP; Epidemiology Division, Pará State Health Secretary, Belém, Pará, Brazil.
Corvelo TCO; Laboratory of Immunogenetics, Institute of Biological Sciences, Federal University of Pará, Belém, Pará, Brazil.
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Źródło :
PloS one [PLoS One] 2020 Nov 18; Vol. 15 (11), pp. e0241487. Date of Electronic Publication: 2020 Nov 18 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Organ Specificity*
ABO Blood-Group System/*metabolism
Antigens/*metabolism
Animals ; Aotidae ; Callithrix ; Platyrrhini ; Saimiri ; Sapajus apella ; Species Specificity
SCR Organism :
Aotus azarae; Saimiri boliviensis
Czasopismo naukowe
Tytuł :
Cells in Silico - introducing a high-performance framework for large-scale tissue modeling.
Autorzy :
Berghoff M; Steinbuch Centre for Computing, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, 76344, Germany.
Rosenbauer J; John von Neumann Institute for Computing, Jülich Supercomputer Centre, Forschungszentrum Jülich, Jülich, 52428, Germany.
Hoffmann F; Steinbuch Centre for Computing, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, 76344, Germany.
Schug A; John von Neumann Institute for Computing, Jülich Supercomputer Centre, Forschungszentrum Jülich, Jülich, 52428, Germany. .; Faculty of Biology, University of Duisburg-Essen, Essen, 45141, Germany. .
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Źródło :
BMC bioinformatics [BMC Bioinformatics] 2020 Oct 06; Vol. 21 (1), pp. 436. Date of Electronic Publication: 2020 Oct 06.
Typ publikacji :
Journal Article
MeSH Terms :
Computer Simulation*
Organ Specificity*
Cells/*metabolism
Biological Transport ; Cell Death ; Diffusion ; Models, Theoretical ; Mutation/genetics ; User-Computer Interface
Czasopismo naukowe
Tytuł :
lncRNAKB, a knowledgebase of tissue-specific functional annotation and trait association of long noncoding RNA.
Autorzy :
Seifuddin F; Bioinformatics and Computational Biology Core, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Singh K; Bioinformatics and Computational Biology Core, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Suresh A; Bioinformatics and Computational Biology Core, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Judy JT; Bioinformatics and Computational Biology Core, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Chen YC; Bioinformatics and Computational Biology Core, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Chaitankar V; Bioinformatics and Computational Biology Core, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Tunc I; Bioinformatics and Computational Biology Core, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Ruan X; Cardiovascular Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Li P; Cardiovascular Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Chen Y; Cardiovascular Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Cao H; Cardiovascular Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Lee RS; Department of Psychiatry & Behavioral Science, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Goes FS; Department of Psychiatry & Behavioral Science, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Zandi PP; Department of Psychiatry & Behavioral Science, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Jafri MS; School of Systems Biology, George Mason University, Manassas, VA, 20110, USA.; Krasnow Institute for Advanced Study, Interdisciplinary Program in Neuroscience, George Mason University, Fairfax, VA, 22030, USA.
Pirooznia M; Bioinformatics and Computational Biology Core, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA. .
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Źródło :
Scientific data [Sci Data] 2020 Oct 05; Vol. 7 (1), pp. 326. Date of Electronic Publication: 2020 Oct 05.
Typ publikacji :
Dataset; Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Knowledge Bases*
Organ Specificity*
RNA, Long Noncoding/*genetics
Humans ; Molecular Sequence Annotation ; Phylogeny ; Quantitative Trait Loci
Czasopismo naukowe
Tytuł :
Intracellular and tissue specific expression of FTO protein in pig: changes with age, energy intake and metabolic status.
Autorzy :
Ferenc K; Veterinary Research Centre, Department of Large Animal Diseases and Clinic, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 100, 02-797, Warsaw, Poland.
Pilžys T; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5A, 02-106, Warsaw, Poland.
Garbicz D; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5A, 02-106, Warsaw, Poland.
Marcinkowski M; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5A, 02-106, Warsaw, Poland.
Skorobogatov O; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5A, 02-106, Warsaw, Poland.
Dylewska M; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5A, 02-106, Warsaw, Poland.
Gajewski Z; Veterinary Research Centre, Department of Large Animal Diseases and Clinic, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 100, 02-797, Warsaw, Poland.
Grzesiuk E; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5A, 02-106, Warsaw, Poland. .
Zabielski R; Veterinary Research Centre, Department of Large Animal Diseases and Clinic, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 100, 02-797, Warsaw, Poland. .
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Źródło :
Scientific reports [Sci Rep] 2020 Aug 03; Vol. 10 (1), pp. 13029. Date of Electronic Publication: 2020 Aug 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Energy Intake*
Organ Specificity*
Aging/*metabolism
Alpha-Ketoglutarate-Dependent Dioxygenase FTO/*metabolism
Intracellular Space/*metabolism
Swine/*metabolism
Alpha-Ketoglutarate-Dependent Dioxygenase FTO/genetics ; Animals ; Animals, Newborn ; Diet ; Female ; Fetal Growth Retardation/metabolism ; Gene Frequency/genetics ; HeLa Cells ; Humans ; Insulin/metabolism ; Insulin-Secreting Cells/metabolism ; Male ; Polymorphism, Single Nucleotide/genetics
Czasopismo naukowe
Tytuł :
Sex related differences in the pathogenesis of organ fibrosis.
Autorzy :
Garate-Carrillo A; Department of Medicine, School of Medicine, University of California, San Diego, California; Seccion de Estudios de Posgrado e Investigacion, Escuela Superior de Medicina, Instituto Politecnico Nacional, Mexico city, Mexico.
Gonzalez J; Department of Medicine, School of Medicine, University of California, San Diego, California.
Ceballos G; Seccion de Estudios de Posgrado e Investigacion, Escuela Superior de Medicina, Instituto Politecnico Nacional, Mexico city, Mexico.
Ramirez-Sanchez I; Department of Medicine, School of Medicine, University of California, San Diego, California; Seccion de Estudios de Posgrado e Investigacion, Escuela Superior de Medicina, Instituto Politecnico Nacional, Mexico city, Mexico.
Villarreal F; Department of Medicine, School of Medicine, University of California, San Diego, California; VA San Diego Health Care, San Diego, California. Electronic address: .
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Źródło :
Translational research : the journal of laboratory and clinical medicine [Transl Res] 2020 Aug; Vol. 222, pp. 41-55. Date of Electronic Publication: 2020 Mar 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms :
Organ Specificity*
Sex Characteristics*
Animals ; Disease Models, Animal ; Female ; Fibrosis ; Humans ; Male
Czasopismo naukowe
Tytuł :
Extrapulmonary manifestations of COVID-19.
Autorzy :
Gupta A; Division of Cardiology, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, NY, USA.; Clinical Trials Center, Cardiovascular Research Foundation, New York, NY, USA.; Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, CT, USA.
Madhavan MV; Division of Cardiology, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, NY, USA.; Clinical Trials Center, Cardiovascular Research Foundation, New York, NY, USA.
Sehgal K; Division of Hematology and Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.
Nair N; Division of Endocrinology, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, New York, NY, USA.
Mahajan S; Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, CT, USA.; Division of Cardiology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Sehrawat TS; Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
Bikdeli B; Division of Cardiology, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, NY, USA.; Clinical Trials Center, Cardiovascular Research Foundation, New York, NY, USA.; Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, CT, USA.
Ahluwalia N; Division of Cardiology, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ausiello JC; Division of Endocrinology, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, New York, NY, USA.
Wan EY; Division of Cardiology, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, NY, USA.
Freedberg DE; Division of Digestive and Liver Diseases, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, NY, USA.
Kirtane AJ; Clinical Trials Center, Cardiovascular Research Foundation, New York, NY, USA.
Parikh SA; Division of Cardiology, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, NY, USA.; Clinical Trials Center, Cardiovascular Research Foundation, New York, NY, USA.
Maurer MS; Division of Cardiology, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, NY, USA.
Nordvig AS; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University and the NewYork-Presbyterian Hospital, New York, NY, USA.
Accili D; Division of Endocrinology, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, New York, NY, USA.
Bathon JM; Division of Rheumatology, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, NY, USA.
Mohan S; Division of Nephrology, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, NY, USA.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.
Bauer KA; Division of Hematology and Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.
Leon MB; Division of Cardiology, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, NY, USA.; Clinical Trials Center, Cardiovascular Research Foundation, New York, NY, USA.
Krumholz HM; Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, CT, USA.; Division of Cardiology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.; Department of Health Policy and Management, Yale School of Public Health, New Haven, CT, USA.
Uriel N; Division of Cardiology, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, NY, USA.
Mehra MR; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital Heart and Vascular Center and Harvard Medical School, Boston, MA, USA.
Elkind MSV; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University and the NewYork-Presbyterian Hospital, New York, NY, USA.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.
Stone GW; Clinical Trials Center, Cardiovascular Research Foundation, New York, NY, USA.; Division of Cardiology, Department of Medicine, the Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Schwartz A; Division of Cardiology, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, NY, USA.
Ho DD; Aaron Diamond AIDS Research Center, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, NY, USA.
Bilezikian JP; Division of Endocrinology, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, New York, NY, USA.
Landry DW; Division of Nephrology, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, NY, USA. .
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Źródło :
Nature medicine [Nat Med] 2020 Jul; Vol. 26 (7), pp. 1017-1032. Date of Electronic Publication: 2020 Jul 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.; Review
MeSH Terms :
Organ Specificity*
Betacoronavirus/*pathogenicity
Coronavirus Infections/*pathology
Pneumonia, Viral/*pathology
Adaptive Immunity/physiology ; Betacoronavirus/physiology ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/immunology ; Coronavirus Infections/therapy ; Disease Progression ; Endothelium, Vascular/pathology ; Endothelium, Vascular/virology ; Humans ; Inflammation/etiology ; Inflammation/pathology ; Inflammation/virology ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/immunology ; Pneumonia, Viral/therapy ; Renin-Angiotensin System/physiology ; SARS-CoV-2 ; Thrombosis/etiology ; Thrombosis/pathology ; Thrombosis/virology ; Virus Internalization
Czasopismo naukowe
Tytuł :
Structural cells are key regulators of organ-specific immune responses.
Autorzy :
Krausgruber T; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Fortelny N; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Fife-Gernedl V; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Senekowitsch M; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Schuster LC; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Division of Chromatin Networks, German Cancer Research Center (DKFZ) and Bioquant, Heidelberg, Germany.
Lercher A; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Nemc A; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Schmidl C; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Regensburg Center for Interventional Immunology (RCI), Regensburg, Germany.
Rendeiro AF; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Bergthaler A; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Bock C; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria. .; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria. .
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Źródło :
Nature [Nature] 2020 Jul; Vol. 583 (7815), pp. 296-302. Date of Electronic Publication: 2020 Jul 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endothelium/*immunology
Epithelial Cells/*immunology
Fibroblasts/*immunology
Gene Expression Regulation/*immunology
Immune System/*cytology
Immune System/*immunology
Organ Specificity/*immunology
Adaptive Immunity ; Animals ; Chromatin/genetics ; Chromatin/metabolism ; Endothelium/cytology ; Epigenesis, Genetic/immunology ; Epigenome/genetics ; Epithelial Cells/cytology ; Female ; Fibroblasts/cytology ; Gene Expression Regulation/genetics ; Gene Regulatory Networks/genetics ; Gene Regulatory Networks/immunology ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/immunology ; Immune System/virology ; Immunity, Innate ; Lymphocytic Choriomeningitis/immunology ; Lymphocytic Choriomeningitis/virology ; Lymphocytic choriomeningitis virus/immunology ; Male ; Mice ; Organ Specificity/genetics ; Transcription, Genetic/immunology ; Transcriptome/genetics
Czasopismo naukowe
Tytuł :
Using Caenorhabditis elegans to Screen for Tissue-Specific Chaperone Interactions.
Autorzy :
Dror S; Department of Life Sciences, Ben-Gurion University of the Negev; .
Meidan TD; Department of Life Sciences, Ben-Gurion University of the Negev.
Karady I; Department of Life Sciences, Ben-Gurion University of the Negev.
Ben-Zvi A; Department of Life Sciences, Ben-Gurion University of the Negev.
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Źródło :
Journal of visualized experiments : JoVE [J Vis Exp] 2020 Jun 07 (160). Date of Electronic Publication: 2020 Jun 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms :
Mass Screening*
Organ Specificity*
Caenorhabditis elegans/*metabolism
Molecular Chaperones/*metabolism
Animals ; Biological Assay ; Caenorhabditis elegans/embryology ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans Proteins/metabolism ; Embryo, Nonmammalian/metabolism ; Epistasis, Genetic ; Mitochondria/metabolism ; Ovum/metabolism ; Phenotype ; Protein Binding ; Protein Folding ; Proteome/metabolism ; RNA Interference ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
Arabidopsis PEAPODs function with LIKE HETEROCHROMATIN PROTEIN1 to regulate lateral organ growth.
Autorzy :
Zhu Y; National Key Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, 200032, China.
Luo X; National Key Laboratory of Plant Molecular Genetics, Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, 201602, China.
Liu X; National Key Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, 200032, China.
Wu W; Shanghai Key Laboratory of Plant Molecular Sciences, College of Life Sciences,, Shanghai Normal University,, Shanghai, 200234, China.
Cui X; National Key Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, 200032, China.
He Y; National Key Laboratory of Plant Molecular Genetics, Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, 201602, China.
Huang J; Shanghai Key Laboratory of Plant Molecular Sciences, College of Life Sciences,, Shanghai Normal University,, Shanghai, 200234, China.
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Źródło :
Journal of integrative plant biology [J Integr Plant Biol] 2020 Jun; Vol. 62 (6), pp. 812-831. Date of Electronic Publication: 2019 Sep 25.
Typ publikacji :
Journal Article
MeSH Terms :
Organ Specificity*
Arabidopsis/*growth & development
Arabidopsis/*metabolism
Arabidopsis Proteins/*metabolism
DNA-Binding Proteins/*metabolism
Transcription Factors/*metabolism
Alleles ; Arabidopsis/cytology ; Arabidopsis/genetics ; Arabidopsis Proteins/genetics ; Cell Cycle/genetics ; Cell Proliferation/genetics ; Co-Repressor Proteins/metabolism ; DNA-Binding Proteins/genetics ; Epistasis, Genetic ; Flowers/growth & development ; Gene Expression Regulation, Plant ; Gene Silencing ; Morphogenesis ; Mutation/genetics ; Plant Leaves/growth & development ; Polycomb-Group Proteins/metabolism ; Protein Binding ; Transcription Factors/genetics ; Transcriptome/genetics
Czasopismo naukowe
Tytuł :
Organ-specific regulation of CHD1 by acute PTEN and p53 loss in mice.
Autorzy :
Rahmy S; Department of Biological Sciences, Boler-Parseghian Center for Rare and Neglected Diseases, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, 46556, USA; Integrated Biomedical Sciences Graduate Program, University of Notre Dame, Notre Dame, IN, 46556, USA.
Cheng X; Department of Biological Sciences, Boler-Parseghian Center for Rare and Neglected Diseases, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, 46556, USA; Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, PR China; Department of General Surgery, Ruijin North Hospital, Shanghai Jiaotong University School of Medicine, 201801, Shanghai, PR China.
Wang M; Department of Biological Sciences, Boler-Parseghian Center for Rare and Neglected Diseases, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, 46556, USA.
Feng H; Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, PR China.
Qiu W; Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, PR China.
Zhao R; Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, PR China; Department of General Surgery, Ruijin North Hospital, Shanghai Jiaotong University School of Medicine, 201801, Shanghai, PR China. Electronic address: .
Lu X; Department of Biological Sciences, Boler-Parseghian Center for Rare and Neglected Diseases, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, 46556, USA; Integrated Biomedical Sciences Graduate Program, University of Notre Dame, Notre Dame, IN, 46556, USA; Tumor Microenvironment and Metastasis Program, Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN, 46202, USA. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 May 07; Vol. 525 (3), pp. 614-619. Date of Electronic Publication: 2020 Feb 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Organ Specificity*
DNA-Binding Proteins/*metabolism
PTEN Phosphohydrolase/*metabolism
Tumor Suppressor Protein p53/*metabolism
Animals ; DNA Copy Number Variations/genetics ; DNA-Binding Proteins/deficiency ; Disease Models, Animal ; Gene Dosage ; Male ; Mice, Knockout ; Mice, Transgenic ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphorylation ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/pathology ; Proto-Oncogene Proteins c-akt/metabolism ; Tamoxifen/pharmacology ; Tumor Suppressor Protein p53/deficiency
Czasopismo naukowe
Tytuł :
A HaloTag-TEV genetic cassette for mechanical phenotyping of proteins from tissues.
Autorzy :
Rivas-Pardo JA; Department of Biological Sciences, Columbia University, New York, NY, 10027, USA.; Center for Genomics and Bioinformatics, Facultad de Ciencias, Universidad Mayor, Santiago, Chile.
Li Y; Institute of Physiology II, University of Muenster, Muenster, Germany.
Mártonfalvi Z; Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary.
Tapia-Rojo R; Department of Biological Sciences, Columbia University, New York, NY, 10027, USA.
Unger A; Institute of Physiology II, University of Muenster, Muenster, Germany.
Fernández-Trasancos Á; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Herrero-Galán E; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Velázquez-Carreras D; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Fernández JM; Department of Biological Sciences, Columbia University, New York, NY, 10027, USA.
Linke WA; Institute of Physiology II, University of Muenster, Muenster, Germany. .
Alegre-Cebollada J; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. .
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Źródło :
Nature communications [Nat Commun] 2020 Apr 28; Vol. 11 (1), pp. 2060. Date of Electronic Publication: 2020 Apr 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Organ Specificity*
Connectin/*metabolism
Endopeptidases/*genetics
Animals ; Biomechanical Phenomena ; Connectin/chemistry ; Female ; Immobilized Proteins/metabolism ; Magnetics ; Mice ; Muscles/metabolism ; Muscles/ultrastructure ; Optical Tweezers ; Phenotype ; Protein Folding ; Spectrum Analysis
Czasopismo naukowe
Tytuł :
Alary muscles and thoracic alary-related muscles are atypical striated muscles involved in maintaining the position of internal organs.
Autorzy :
Bataillé L; Centre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de Toulouse 3, CNRS, UPS, 118 route de Narbonne, 31062 Toulouse, France .
Colombié N; Centre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de Toulouse 3, CNRS, UPS, 118 route de Narbonne, 31062 Toulouse, France.
Pelletier A; Centre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de Toulouse 3, CNRS, UPS, 118 route de Narbonne, 31062 Toulouse, France.
Paululat A; University of Osnabrück, Department of Biology/Chemistry, Zoology and Developmental Biology, Barbarastraße 11, 49076 Osnabrück, Germany.
Lebreton G; Centre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de Toulouse 3, CNRS, UPS, 118 route de Narbonne, 31062 Toulouse, France.
Carrier Y; Centre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de Toulouse 3, CNRS, UPS, 118 route de Narbonne, 31062 Toulouse, France.
Frendo JL; Centre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de Toulouse 3, CNRS, UPS, 118 route de Narbonne, 31062 Toulouse, France.
Vincent A; Centre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de Toulouse 3, CNRS, UPS, 118 route de Narbonne, 31062 Toulouse, France.
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Źródło :
Development (Cambridge, England) [Development] 2020 Apr 24; Vol. 147 (8). Date of Electronic Publication: 2020 Apr 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Organ Specificity*
Drosophila melanogaster/*anatomy & histology
Muscle, Striated/*physiology
Thorax/*physiology
Animals ; Calcium/metabolism ; Digestive System/metabolism ; Drosophila melanogaster/genetics ; Food ; Gastrointestinal Transit ; Genes, Homeobox ; Heart/physiology ; Intracellular Space/metabolism ; Larva/physiology ; Locomotion ; Sarcomeres/metabolism ; Trachea/physiology
Czasopismo naukowe
Tytuł :
An energy landscape approach to understanding variety and robustness in tissue morphogenesis.
Autorzy :
Takeda H; Department of Micro Engineering, Graduate School of Engineering, Kyoto University, 53 Shogoin-Kawahara-cho, Sakyo, Kyoto, 606-8507, Japan.; Department of Biosystems Science, Institute for Frontier Life and Medical Sciences, Kyoto University, 53 Shogoin-Kawahara-cho, Sakyo, Kyoto, 606-8507, Japan.
Kameo Y; Department of Micro Engineering, Graduate School of Engineering, Kyoto University, 53 Shogoin-Kawahara-cho, Sakyo, Kyoto, 606-8507, Japan.; Department of Biosystems Science, Institute for Frontier Life and Medical Sciences, Kyoto University, 53 Shogoin-Kawahara-cho, Sakyo, Kyoto, 606-8507, Japan.; Division of Systemic Life Science, Graduate School of Biostudies, Kyoto University, 53 Shogoin-Kawahara-cho, Sakyo, Kyoto, 606-8507, Japan.
Inoue Y; Department of Micro Engineering, Graduate School of Engineering, Kyoto University, 53 Shogoin-Kawahara-cho, Sakyo, Kyoto, 606-8507, Japan.; Department of Biosystems Science, Institute for Frontier Life and Medical Sciences, Kyoto University, 53 Shogoin-Kawahara-cho, Sakyo, Kyoto, 606-8507, Japan.; Division of Systemic Life Science, Graduate School of Biostudies, Kyoto University, 53 Shogoin-Kawahara-cho, Sakyo, Kyoto, 606-8507, Japan.
Adachi T; Department of Micro Engineering, Graduate School of Engineering, Kyoto University, 53 Shogoin-Kawahara-cho, Sakyo, Kyoto, 606-8507, Japan. .; Department of Biosystems Science, Institute for Frontier Life and Medical Sciences, Kyoto University, 53 Shogoin-Kawahara-cho, Sakyo, Kyoto, 606-8507, Japan. .; Division of Systemic Life Science, Graduate School of Biostudies, Kyoto University, 53 Shogoin-Kawahara-cho, Sakyo, Kyoto, 606-8507, Japan. .
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Źródło :
Biomechanics and modeling in mechanobiology [Biomech Model Mechanobiol] 2020 Apr; Vol. 19 (2), pp. 471-479. Date of Electronic Publication: 2019 Sep 07.
Typ publikacji :
Journal Article
MeSH Terms :
Morphogenesis*
Organ Specificity*
Microvilli/physiology ; Models, Biological ; Thermodynamics
Czasopismo naukowe
Tytuł :
Multiscale composite model of fiber-reinforced tissues with direct representation of sub-tissue properties.
Autorzy :
Zhou M; Department of Mechanical Engineering, University of California, Berkeley, 5122 Etcheverry Hall, #1740, Berkeley, CA, 94720-1740, USA.
Bezci SE; Department of Mechanical Engineering, University of California, Berkeley, 5122 Etcheverry Hall, #1740, Berkeley, CA, 94720-1740, USA.
O'Connell GD; Department of Mechanical Engineering, University of California, Berkeley, 5122 Etcheverry Hall, #1740, Berkeley, CA, 94720-1740, USA. .; Department of Orthopaedic Surgery, University of California, San Francisco, San Francisco, USA. .
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Źródło :
Biomechanics and modeling in mechanobiology [Biomech Model Mechanobiol] 2020 Apr; Vol. 19 (2), pp. 745-759. Date of Electronic Publication: 2019 Nov 04.
Typ publikacji :
Journal Article
MeSH Terms :
Models, Biological*
Organ Specificity*
Biomechanical Phenomena ; Calibration ; Elastic Modulus ; Finite Element Analysis ; Reproducibility of Results ; Stress, Mechanical ; Tensile Strength
Czasopismo naukowe
Tytuł :
Tissue-specific synergistic bio-priming of pepper by two Streptomyces species against Phytophthora capsici.
Autorzy :
Abbasi S; Department of Plant Pathology, Faculty of Agriculture, Tarbiat Modares University, Tehran, Iran.
Safaie N; Department of Plant Pathology, Faculty of Agriculture, Tarbiat Modares University, Tehran, Iran.
Sadeghi A; Department of Microbial Biotechnology, Agricultural Biotechnology Research Institute of Iran (ABRII), Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran.
Shamsbakhsh M; Department of Plant Pathology, Faculty of Agriculture, Tarbiat Modares University, Tehran, Iran.
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Źródło :
PloS one [PLoS One] 2020 Mar 19; Vol. 15 (3), pp. e0230531. Date of Electronic Publication: 2020 Mar 19 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Organ Specificity*/genetics
Capsicum/*microbiology
Phytophthora/*physiology
Streptomyces/*physiology
Aminobutyrates/pharmacology ; Capsicum/genetics ; Capsicum/growth & development ; Fruit/genetics ; Gene Expression Regulation, Plant ; Genes, Plant ; Hydrogen Peroxide/metabolism ; Plant Diseases/genetics ; Plant Diseases/microbiology ; Plant Leaves/genetics
Czasopismo naukowe
Tytuł :
Identification of region-specific astrocyte subtypes at single cell resolution.
Autorzy :
Batiuk MY; Laboratory of Glia Biology, VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium.; Laboratory of Glia Biology, KU Leuven Department of Neuroscience, Leuven, Belgium.
Martirosyan A; Laboratory of Glia Biology, VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium.; Laboratory of Glia Biology, KU Leuven Department of Neuroscience, Leuven, Belgium.
Wahis J; Laboratory of Glia Biology, VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium.; Laboratory of Glia Biology, KU Leuven Department of Neuroscience, Leuven, Belgium.
de Vin F; Laboratory of Glia Biology, VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium.; Laboratory of Glia Biology, KU Leuven Department of Neuroscience, Leuven, Belgium.
Marneffe C; Laboratory of Glia Biology, VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium.; Laboratory of Glia Biology, KU Leuven Department of Neuroscience, Leuven, Belgium.
Kusserow C; Laboratory of Glia Biology, VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium.; Laboratory of Glia Biology, KU Leuven Department of Neuroscience, Leuven, Belgium.
Koeppen J; Laboratory of Glia Biology, VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium.; Laboratory of Glia Biology, KU Leuven Department of Neuroscience, Leuven, Belgium.
Viana JF; Life and Health Sciences Research Institute (ICVS), University of Minho, Braga, Portugal.; ICVS/3Bs - PT Government Associate Laboratory, Braga, Portugal.
Oliveira JF; Life and Health Sciences Research Institute (ICVS), University of Minho, Braga, Portugal.; ICVS/3Bs - PT Government Associate Laboratory, Braga, Portugal.; IPCA-EST-2Ai, Polytechnic Institute of Cávado and Ave, Applied Artificial Intelligence Laboratory, IPCA Campus, Barcelos, Portugal.
Voet T; Sanger Institute-EBI Single-Cell Genomics Centre, Wellcome Trust Sanger Institute, Hinxton, UK.; KU Leuven Department of Human Genetics, Leuven, Belgium.
Ponting CP; Sanger Institute-EBI Single-Cell Genomics Centre, Wellcome Trust Sanger Institute, Hinxton, UK.; MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Belgard TG; MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.; The Bioinformatics CRO, Niceville, Florida, 32578, USA.
Holt MG; Laboratory of Glia Biology, VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium. .; Laboratory of Glia Biology, KU Leuven Department of Neuroscience, Leuven, Belgium. .; Leuven Brain Institute, KU Leuven, Leuven, Belgium. .
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Źródło :
Nature communications [Nat Commun] 2020 Mar 05; Vol. 11 (1), pp. 1220. Date of Electronic Publication: 2020 Mar 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Organ Specificity*/genetics
Single-Cell Analysis*
Astrocytes/*cytology
Animals ; Astrocytes/metabolism ; Calcium Signaling ; Cell Shape ; Gene Expression Regulation ; Mice, Inbred C57BL ; Neurogenesis/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
Czasopismo naukowe
Tytuł :
Body site-specific genetic effects influence naevus count distribution in women.
Autorzy :
Visconti A; Department of Twin Research & Genetic Epidemiology, King's College London, London, UK.
Ribero S; Department of Medical Sciences, Section of Dermatology, University of Turin, Turin, Italy.
Sanna M; Department of Twin Research & Genetic Epidemiology, King's College London, London, UK.
Spector TD; Department of Twin Research & Genetic Epidemiology, King's College London, London, UK.
Bataille V; Department of Twin Research & Genetic Epidemiology, King's College London, London, UK.; Department of Dermatology, West Herts NHS Trust, Herts, UK.
Falchi M; Department of Twin Research & Genetic Epidemiology, King's College London, London, UK.
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Źródło :
Pigment cell & melanoma research [Pigment Cell Melanoma Res] 2020 Mar; Vol. 33 (2), pp. 326-333. Date of Electronic Publication: 2019 Aug 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Twin Study
MeSH Terms :
Organ Specificity*/genetics
Nevus, Pigmented/*genetics
Female ; Genetic Predisposition to Disease ; Humans ; Inheritance Patterns/genetics ; Male ; Polymorphism, Single Nucleotide/genetics
Czasopismo naukowe
Tytuł :
Optical mapping of electromechanics in intact organs.
Autorzy :
Nesmith HW; Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Zhang H; Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Rogers JM; Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
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Źródło :
Experimental biology and medicine (Maywood, N.J.) [Exp Biol Med (Maywood)] 2020 Feb; Vol. 245 (4), pp. 368-373. Date of Electronic Publication: 2019 Dec 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Electrophysiological Phenomena*
Optical Imaging*
Organ Specificity*
Action Potentials ; Animals ; Artifacts ; Electricity ; Heart/physiology ; Motion ; Swine
Czasopismo naukowe

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