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Wyszukujesz frazę ""Organothiophosphorus compounds"" wg kryterium: Temat


Tytuł:
Chemical, Physical, and Toxicological Properties of V-Agents.
Autorzy:
Pampalakis G; Laboratory of Pharmacology, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Kostoudi S; Laboratory of Pharmacology, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 May 11; Vol. 24 (10). Date of Electronic Publication: 2023 May 11.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Chemical Warfare Agents*/chemistry
Organothiophosphorus Compounds*/chemistry
Nerve Agents*/toxicity
Nerve Agents*/chemistry
Pesticides*/toxicity
Czasopismo naukowe
Tytuł:
COPD and asthma therapeutics for supportive treatment in organophosphate poisoning.
Autorzy:
Herbert J; a Bundeswehr Institute of Pharmacology and Toxicology , Neuherbergstraße 11, Munich , Germany.
Thiermann H; a Bundeswehr Institute of Pharmacology and Toxicology , Neuherbergstraße 11, Munich , Germany.
Worek F; a Bundeswehr Institute of Pharmacology and Toxicology , Neuherbergstraße 11, Munich , Germany.
Wille T; a Bundeswehr Institute of Pharmacology and Toxicology , Neuherbergstraße 11, Munich , Germany.
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Źródło:
Clinical toxicology (Philadelphia, Pa.) [Clin Toxicol (Phila)] 2019 Jul; Vol. 57 (7), pp. 644-651. Date of Electronic Publication: 2019 Jan 30.
Typ publikacji:
Journal Article
MeSH Terms:
Adrenergic beta-2 Receptor Agonists/*pharmacology
Chemical Warfare Agents/*poisoning
Cholinergic Antagonists/*pharmacology
Organophosphate Poisoning/*drug therapy
Organothiophosphorus Compounds/*poisoning
Adrenergic beta-2 Receptor Agonists/administration & dosage ; Animals ; Anti-Asthmatic Agents/administration & dosage ; Anti-Asthmatic Agents/pharmacology ; Cholinergic Antagonists/administration & dosage ; Disease Models, Animal ; Male ; Microscopy, Video ; Organophosphate Poisoning/physiopathology ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł:
An enhanced butyrylcholinesterase method to measure organophosphorus nerve agent exposure in humans.
Autorzy:
Pantazides BG; Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, NE, Atlanta, GA, 30341, USA.
Watson CM
Carter MD
Crow BS
Perez JW
Blake TA
Thomas JD
Johnson RC
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Źródło:
Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2014 Aug; Vol. 406 (21), pp. 5187-94. Date of Electronic Publication: 2014 Mar 07.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:
Biological Assay*
Butyrylcholinesterase/*chemistry
Chemical Warfare Agents/*analysis
Organothiophosphorus Compounds/*blood
Sarin/*blood
Antibodies, Monoclonal/chemistry ; Chemical Warfare Agents/chemistry ; Chromatography, Liquid ; Humans ; Immunomagnetic Separation ; In Vitro Techniques ; Organothiophosphorus Compounds/chemistry ; Sarin/chemistry ; Tandem Mass Spectrometry
Czasopismo naukowe
Tytuł:
Bioanalytical verification of V-type nerve agent exposure: simultaneous detection of phosphonylated tyrosines and cysteine-containing disulfide-adducts derived from human albumin.
Autorzy:
Kranawetvogl A; Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937, Munich, Germany.
Küppers J; Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany.
Siegert M; Department of Chemistry, Humboldt-Universität zu Berlin, Brook-Taylor-Strasse 2, 12489, Berlin, Germany.
Gütschow M; Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany.
Worek F; Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937, Munich, Germany.
Thiermann H; Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937, Munich, Germany.
Elsinghorst PW; Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany.; Central Institute of the Bundeswehr Medical Service Munich, Ingolstädter Landstrasse 102, 85748, Garching, Germany.
John H; Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937, Munich, Germany. .
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Źródło:
Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2018 Feb; Vol. 410 (5), pp. 1463-1474. Date of Electronic Publication: 2018 Jan 10.
Typ publikacji:
Journal Article
MeSH Terms:
Chemical Warfare Agents/*chemistry
Cysteine/*chemistry
Disulfides/*chemistry
Nerve Agents/*chemistry
Organothiophosphorus Compounds/*chemistry
Serum Albumin, Human/*chemistry
Tyrosine/*chemistry
Acetylcholinesterase/chemistry ; Catalysis ; Dose-Response Relationship, Drug ; Humans ; Kinetics ; Models, Molecular ; Phosphorylation ; Tandem Mass Spectrometry
Czasopismo naukowe
Tytuł:
Specificity enhancement by electrospray ionization multistage mass spectrometry--a valuable tool for differentiation and identification of 'V'-type chemical warfare agents.
Autorzy:
Weissberg A; Analytical Chemistry Department, Israel Institute for Biological Research (IIBR), P.O.B. 19, Ness-Ziona, Israel.
Tzanani N
Dagan S
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Źródło:
Journal of mass spectrometry : JMS [J Mass Spectrom] 2013 Dec; Vol. 48 (12), pp. 1340-8.
Typ publikacji:
Journal Article
MeSH Terms:
Chemical Warfare Agents/*analysis
Organothiophosphorus Compounds/*analysis
Spectrometry, Mass, Electrospray Ionization/*methods
Chemical Warfare Agents/chemistry ; Organothiophosphorus Compounds/chemistry ; Tandem Mass Spectrometry/methods
Czasopismo naukowe
Tytuł:
Derivatization of organophosphorus nerve agent degradation products for gas chromatography with ICPMS and TOF-MS detection.
Autorzy:
Richardson DD; Department of Chemistry, McMicken College of Arts and Sciences, University of Cincinnati, Cincinnati, OH 45221-0172, USA.
Caruso JA
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Źródło:
Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2007 Jun; Vol. 388 (4), pp. 809-23. Date of Electronic Publication: 2007 Mar 14.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Chemical Warfare Agents/*metabolism
Gas Chromatography-Mass Spectrometry/*methods
Organothiophosphorus Compounds/*metabolism
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/*methods
Chemical Warfare Agents/chemistry ; Organophosphonates/analysis ; Organophosphonates/chemistry ; Organophosphorus Compounds/analysis ; Organophosphorus Compounds/chemistry ; Organosilicon Compounds/analysis ; Organosilicon Compounds/chemistry ; Organothiophosphorus Compounds/chemistry ; Rivers/chemistry ; Sensitivity and Specificity ; Soil/chemistry ; Soman/analogs & derivatives ; Soman/analysis ; Soman/chemistry ; Temperature ; Time Factors ; Volatilization ; Water Pollutants, Chemical/analysis
Czasopismo naukowe
Tytuł:
Butyrylcholinesterase in guinea pig lung lavage: a novel biomarker to assess lung injury following inhalation exposure to nerve agent VX.
Autorzy:
Graham JR; Department of Biochemical Pharmacology/Division of Biochemistry, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA.
Wright BS
Rezk PE
Gordon RK
Sciuto AM
Nambiar MP
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Źródło:
Inhalation toxicology [Inhal Toxicol] 2006 Jun; Vol. 18 (7), pp. 493-500.
Typ publikacji:
Journal Article
MeSH Terms:
Inhalation Exposure*
Bronchoalveolar Lavage Fluid/*chemistry
Butyrylcholinesterase/*metabolism
Chemical Warfare Agents/*toxicity
Cholinesterase Inhibitors/*toxicity
Lung/*drug effects
Organothiophosphorus Compounds/*toxicity
Acetylcholinesterase/metabolism ; Animals ; Biomarkers ; Female ; Guinea Pigs ; Lung/enzymology ; Male ; Organothiophosphorus Compounds/administration & dosage
Czasopismo naukowe
Tytuł:
Evaluation of a barrier cream against the chemical warfare agent VX using the domestic white pig.
Autorzy:
Chilcott RP; Chemical Hazards and Poisons Division, Health Protection Agency, Chilton, Didcot, Oxfordshire, OX11 0RQ, UK.
Dalton CH
Hill I
Davison CM
Blohm KL
Clarkson ED
Hamilton MG
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Źródło:
Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2005 Jul; Vol. 97 (1), pp. 35-8.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chemical Warfare Agents/*toxicity
Cholinesterase Inhibitors/*toxicity
Organothiophosphorus Compounds/*toxicity
Skin Absorption/*drug effects
Animals ; Lethal Dose 50 ; Ointments ; Organothiophosphorus Compounds/pharmacokinetics ; Swine
Czasopismo naukowe
Tytuł:
Preliminary assessment of health impacts for the Newport Chemical Agent Disposal Facility.
Autorzy:
Fathimulla F; U.S. Army Center for Health Promotion and Preventive Medicine, APG-EA, MD 21010, USA.
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Źródło:
Drug and chemical toxicology [Drug Chem Toxicol] 2000 Feb; Vol. 23 (1), pp. 55-66.
Typ publikacji:
Journal Article
MeSH Terms:
Hazardous Waste*/analysis
Air Pollutants/*toxicity
Chemical Warfare Agents/*toxicity
Organothiophosphorus Compounds/*toxicity
Water Pollutants, Chemical/*toxicity
Air Pollutants/analysis ; Animals ; Chemical Warfare Agents/chemistry ; Humans ; Indiana ; Military Personnel ; Models, Theoretical ; Organothiophosphorus Compounds/chemistry ; Oxidation-Reduction ; Rabbits ; Rats ; Risk Assessment ; Toxicity Tests ; Water Pollutants, Chemical/analysis
Czasopismo naukowe
Tytuł:
Differentiated NSC-34 cells as an in vitro cell model for VX.
Autorzy:
Kanjilal B; Pharmacology and Immunology Branch, U.S. Army Medical Research Institute of Chemical Defense , MD , USA and.
Keyser BM
Andres DK
Nealley E
Benton B
Melber AA
Andres JF
Letukas VA
Clark O
Ray R
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Źródło:
Toxicology mechanisms and methods [Toxicol Mech Methods] 2014 Oct; Vol. 24 (7), pp. 488-94. Date of Electronic Publication: 2014 Sep 11.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Cell Differentiation*
Chemical Warfare Agents/*toxicity
Organothiophosphorus Compounds/*toxicity
Caspase 3/metabolism ; Caspase 9/metabolism ; Enzyme Activation ; Flow Cytometry ; In Vitro Techniques
Czasopismo naukowe
Tytuł:
Determination of nerve agent metabolites in human urine by isotope-dilution gas chromatography-tandem mass spectrometry after solid phase supported derivatization.
Autorzy:
Lin Y; State Key Laboratory of Toxicology and Antitoxic Countermeasures, and Laboratory of Toxicant Analysis, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, 27 Taiping Road, Haidian District, Beijing, 100850, China.
Chen J
Yan L
Guo L
Wu B
Li C
Feng J
Liu Q
Xie J
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Źródło:
Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2014 Aug; Vol. 406 (21), pp. 5213-20. Date of Electronic Publication: 2014 Mar 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chemical Warfare Agents/*analysis
Organophosphonates/*urine
Organophosphorus Compounds/*urine
Organothiophosphorus Compounds/*urine
Sarin/*urine
Soman/*analogs & derivatives
Soman/*urine
Biotransformation ; Chemical Warfare Agents/metabolism ; Fluorobenzenes/chemistry ; Gas Chromatography-Mass Spectrometry/methods ; Humans ; In Vitro Techniques ; Indicator Dilution Techniques ; Limit of Detection ; Liquid-Liquid Extraction
Czasopismo naukowe
Tytuł:
V-type nerve agents phosphonylate ubiquitin at biologically relevant lysine residues and induce intramolecular cyclization by an isopeptide bond.
Autorzy:
Schmidt C; Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937, Munich, Germany.
Breyer F
Blum MM
Thiermann H
Worek F
John H
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Źródło:
Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2014 Aug; Vol. 406 (21), pp. 5171-85. Date of Electronic Publication: 2014 Mar 21.
Typ publikacji:
Journal Article
MeSH Terms:
Chemical Warfare Agents/*chemistry
Glutamic Acid/*chemistry
Lysine/*chemistry
Organothiophosphorus Compounds/*chemistry
Phosphorous Acids/*chemistry
Ubiquitin/*chemistry
Amino Acid Sequence ; Chromatography, High Pressure Liquid ; Cyclization ; Humans ; Models, Molecular ; Molecular Sequence Data ; Solutions ; Spectrometry, Mass, Electrospray Ionization ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Czasopismo naukowe
Tytuł:
Quantitation of five organophosphorus nerve agent metabolites in serum using hydrophilic interaction liquid chromatography and tandem mass spectrometry.
Autorzy:
Hamelin EI; Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy, Atlanta, GA, 30341, USA, .
Schulze ND
Shaner RL
Coleman RM
Lawrence RJ
Crow BS
Jakubowski EM
Johnson RC
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Źródło:
Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2014 Aug; Vol. 406 (21), pp. 5195-202. Date of Electronic Publication: 2014 Mar 15.
Typ publikacji:
Journal Article
MeSH Terms:
Chemical Warfare Agents/*analysis
Organophosphorus Compounds/*blood
Organothiophosphorus Compounds/*blood
Sarin/*blood
Soman/*blood
Ammonium Compounds ; Biotransformation ; Buffers ; Chemical Warfare Agents/metabolism ; Chromatography, High Pressure Liquid/methods ; Fluorides ; Humans ; Hydrophobic and Hydrophilic Interactions ; In Vitro Techniques ; Limit of Detection ; Quaternary Ammonium Compounds ; Solid Phase Extraction ; Tandem Mass Spectrometry
Czasopismo naukowe
Tytuł:
Chemical analysis of bleach and hydroxide-based solutions after decontamination of the chemical warfare agent O-ethyl S-2-diisopropylaminoethyl methylphosphonothiolate (VX).
Autorzy:
Hopkins FB; Detection Department, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK.
Gravett MR
Self AJ
Wang M
Chua HC
Lee HS
Jones JT
Timperley CM
Riches JR
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Źródło:
Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2014 Aug; Vol. 406 (21), pp. 5111-9. Date of Electronic Publication: 2014 Mar 18.
Typ publikacji:
Journal Article
MeSH Terms:
Chemical Warfare Agents/*isolation & purification
Formamides/*isolation & purification
Organothiophosphorus Compounds/*isolation & purification
Propylamines/*isolation & purification
Decontamination/methods ; Gas Chromatography-Mass Spectrometry ; Humans ; Hydroxides/chemistry ; Magnetic Resonance Spectroscopy ; Sodium Hypochlorite/chemistry ; Solutions
Czasopismo naukowe
Tytuł:
Fate of the chemical warfare agent O-ethyl S-2-diisopropylaminoethyl methylphosphonothiolate (VX) on soil following accelerant-based fire and liquid decontamination.
Autorzy:
Gravett MR; Detection Department, Defence Science and Technology Laboratory (Dstl), G12, Building 383B Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK.
Hopkins FB
Self AJ
Webb AJ
Timperley CM
Riches JR
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Źródło:
Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2014 Aug; Vol. 406 (21), pp. 5121-35. Date of Electronic Publication: 2014 Jun 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Decontamination*
Chemical Warfare Agents/*isolation & purification
Organothiophosphorus Compounds/*isolation & purification
Ecotoxicology/instrumentation ; Ecotoxicology/methods ; Fires ; Forensic Sciences/instrumentation ; Forensic Sciences/methods ; Gas Chromatography-Mass Spectrometry ; Humans ; Kerosene ; Paraffin ; Sodium Hypochlorite/chemistry ; Soil/chemistry
Czasopismo naukowe
Tytuł:
Acute pulmonary toxicity following inhalation exposure to aerosolized VX in anesthetized rats.
Autorzy:
Peng X; Analytical Toxicology Division, Medical Toxicology Branch, United States Army Medical Research Institute of Chemical Defense , Aberdeen Proving Ground, MD , USA.
Perkins MW
Simons J
Witriol AM
Rodriguez AM
Benjamin BM
Devorak J
Sciuto AM
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Źródło:
Inhalation toxicology [Inhal Toxicol] 2014 Jun; Vol. 26 (7), pp. 371-9. Date of Electronic Publication: 2014 Apr 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chemical Warfare Agents/*toxicity
Inhalation Exposure/*adverse effects
Lung/*drug effects
Organophosphate Poisoning/*physiopathology
Organothiophosphorus Compounds/*toxicity
Respiratory Mucosa/*drug effects
Trachea/*drug effects
Acetylcholinesterase/blood ; Acetylcholinesterase/chemistry ; Acetylcholinesterase/metabolism ; Aerosols ; Airway Resistance ; Animals ; Bronchoalveolar Lavage Fluid/chemistry ; Cholinesterase Inhibitors/toxicity ; Dose-Response Relationship, Drug ; Lung/immunology ; Lung/metabolism ; Lung/pathology ; Male ; Necrosis ; Organophosphate Poisoning/enzymology ; Organophosphate Poisoning/immunology ; Organophosphate Poisoning/pathology ; Pneumonia/chemically induced ; Pulmonary Edema/chemically induced ; Rats, Sprague-Dawley ; Respiratory Mucosa/immunology ; Respiratory Mucosa/metabolism ; Respiratory Mucosa/pathology ; Toxicokinetics ; Trachea/immunology ; Trachea/metabolism ; Trachea/pathology ; Ulcer/etiology ; Weight Loss/drug effects
Czasopismo naukowe
Tytuł:
Determination of LCt(50)s in anesthetized rats exposed to aerosolized nerve agents.
Autorzy:
Collins JL; 27 SOCES/CEAN Cannon Air Force Base, NM 88103, USA.
Peng X
Lee R
Witriol A
Pierre Z
Sciuto AM
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Źródło:
Toxicology mechanisms and methods [Toxicol Mech Methods] 2013 Feb; Vol. 23 (2), pp. 127-33. Date of Electronic Publication: 2012 Oct 19.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Aerosols*
Chemical Warfare Agents/*toxicity
Neurotoxins/*toxicity
Organothiophosphorus Compounds/*toxicity
Sarin/*toxicity
Soman/*toxicity
Administration, Inhalation ; Anesthesia ; Animals ; Dose-Response Relationship, Drug ; Lethal Dose 50 ; Male ; Rats
Czasopismo naukowe
Tytuł:
In vivo decontamination of the nerve agent VX using the domestic swine model.
Autorzy:
Misik J; Faculty of Military Health Sciences, Department of Toxicology, University of Defence, Trebesska, Hradec Kralove, Czech Republic. />Pavlik M
Novotny L
Pavlikova R
Chilcott RP
Cabal J
Kuca K
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Źródło:
Clinical toxicology (Philadelphia, Pa.) [Clin Toxicol (Phila)] 2012 Nov; Vol. 50 (9), pp. 807-11. Date of Electronic Publication: 2012 Sep 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chemical Warfare Agents/*poisoning
Decontamination/*methods
Organothiophosphorus Compounds/*poisoning
Animals ; Cholinesterases/metabolism ; Female ; Sus scrofa
Czasopismo naukowe

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