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Tytuł :
Publisher Correction: Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma.
Autorzy :
Marchetto A; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Ohmura S; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Orth MF; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Knott MML; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Colombo MV; Regenerative Medicine Technologies Laboratory, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland.
Arrigoni C; Regenerative Medicine Technologies Laboratory, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland.
Bardinet V; Department of Pediatrics, Division of Oncology and Hematology, Charité Berlin, Berlin, Germany.
Saucier D; Department of Pediatrics and Molecular Biology, University of Texas Southwestern Medical Center and Children's Medical Center, Dallas, TX, USA.
Wehweck FS; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Li J; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Stein S; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Gerke JS; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Baldauf MC; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Musa J; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Dallmayer M; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Romero-Pérez L; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; Hopp-Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Hölting TLB; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Amatruda JF; Department of Pediatrics and Molecular Biology, University of Texas Southwestern Medical Center and Children's Medical Center, Dallas, TX, USA.; Children's Hospital of Los Angeles, Los Angeles, CA, USA.
Cossarizza A; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Modena, Italy.
Henssen AG; Department of Pediatrics, Division of Oncology and Hematology, Charité Berlin, Berlin, Germany.; Berlin Institute of Health, Berlin, Germany.; Experimental and Clinical Research Center (ECRC) of the MDC and Charité Berlin, Berlin, Germany.; German Cancer Consortium (DKTK), partner site, Berlin, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.
Kirchner T; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), partner site, Munich, Germany.
Moretti M; Regenerative Medicine Technologies Laboratory, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland.
Cidre-Aranaz F; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; Hopp-Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Sannino G; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Grünewald TGP; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany. .; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany. .; Hopp-Children's Cancer Center (KiTZ), Heidelberg, Germany. .; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. .; German Cancer Consortium (DKTK), partner site, Munich, Germany. .; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 23; Vol. 11 (1), pp. 6068. Date of Electronic Publication: 2020 Nov 23.
Typ publikacji :
Published Erratum
Tytuł :
A comparative view on the expression patterns of PD-L1 and PD-1 in soft tissue sarcomas.
Autorzy :
Orth MF; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, Ludwig-Maximilians University Munich, Munich, Germany.
Buecklein VL; Department of Internal Medicine III, Faculty of Medicine, Ludwig-Maximilians University Munich, Munich, Germany.
Kampmann E; Department of Internal Medicine III, Faculty of Medicine, Ludwig-Maximilians University Munich, Munich, Germany.
Subklewe M; Department of Internal Medicine III, Faculty of Medicine, Ludwig-Maximilians University Munich, Munich, Germany.
Noessner E; Institute of Molecular Immunology, Helmholtz Center, Munich, Germany.
Cidre-Aranaz F; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, Ludwig-Maximilians University Munich, Munich, Germany.
Romero-Pérez L; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, Ludwig-Maximilians University Munich, Munich, Germany.
Wehweck FS; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, Ludwig-Maximilians University Munich, Munich, Germany.; Institute of Pathology, Faculty of Medicine, Ludwig-Maximilians University Munich, Thalkirchner Str. 36, 80337, Munich, Germany.
Lindner L; Department of Internal Medicine III, Faculty of Medicine, Ludwig-Maximilians University Munich, Munich, Germany.
Issels R; Department of Internal Medicine III, Faculty of Medicine, Ludwig-Maximilians University Munich, Munich, Germany.
Kirchner T; Institute of Pathology, Faculty of Medicine, Ludwig-Maximilians University Munich, Thalkirchner Str. 36, 80337, Munich, Germany.; German Cancer Consortium (DKTK), partner site Munich, Munich, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.
Altendorf-Hofmann A; Department of General, Visceral and Vascular Surgery, Friedrich-Schiller-University, Jena, Germany.
Grünewald TGP; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, Ludwig-Maximilians University Munich, Munich, Germany. .; Institute of Pathology, Faculty of Medicine, Ludwig-Maximilians University Munich, Thalkirchner Str. 36, 80337, Munich, Germany. .; German Cancer Consortium (DKTK), partner site Munich, Munich, Germany. .; German Cancer Research Center (DKFZ), Heidelberg, Germany. .
Knösel T; Institute of Pathology, Faculty of Medicine, Ludwig-Maximilians University Munich, Thalkirchner Str. 36, 80337, Munich, Germany. .
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2020 Jul; Vol. 69 (7), pp. 1353-1362. Date of Electronic Publication: 2020 Mar 28.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
B7-H1 Antigen/*metabolism
Biomarkers, Tumor/*metabolism
Programmed Cell Death 1 Receptor/*metabolism
Sarcoma/*metabolism
Adolescent ; Adult ; Aged ; Cohort Studies ; Female ; Follow-Up Studies ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Middle Aged ; Neoplasm Metastasis ; Prognosis ; Sarcoma/classification ; Sarcoma/pathology ; Survival Rate ; Young Adult
Czasopismo naukowe
Tytuł :
mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis.
Autorzy :
Triki M; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Herestraat 49, 3000 Leuven, Belgium.
Rinaldi G; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Herestraat 49, 3000 Leuven, Belgium.
Planque M; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Herestraat 49, 3000 Leuven, Belgium.
Broekaert D; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Herestraat 49, 3000 Leuven, Belgium.
Winkelkotte AM; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany; Faculty of Biosciences, University of Heidelberg, 69120 Heidelberg, Germany.
Maier CR; Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter, Am Hubland, 97074 Würzburg, Germany.
Janaki Raman S; Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter, Am Hubland, 97074 Würzburg, Germany.
Vandekeere A; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Herestraat 49, 3000 Leuven, Belgium.
Van Elsen J; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Herestraat 49, 3000 Leuven, Belgium.
Orth MF; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Thalkirchner Strasse 36, 80337 Munich, Germany.
Grünewald TGP; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Thalkirchner Strasse 36, 80337 Munich, Germany; German Cancer Consortium (DKTK), partner site Munich, 80337 Munich, Germany; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Institute of Pathology, Heidelberg University Hospital, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany.
Schulze A; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany; Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter, Am Hubland, 97074 Würzburg, Germany.
Fendt SM; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Herestraat 49, 3000 Leuven, Belgium. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2020 Jun 23; Vol. 31 (12), pp. 107806.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma.
Autorzy :
Marchetto A; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Ohmura S; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Orth MF; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Knott MML; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Colombo MV; Regenerative Medicine Technologies Laboratory, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland.
Arrigoni C; Regenerative Medicine Technologies Laboratory, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland.
Bardinet V; Department of Pediatrics, Division of Oncology and Hematology, Charité Berlin, Berlin, Germany.
Saucier D; Department of Pediatrics and Molecular Biology, University of Texas Southwestern Medical Center and Children's Medical Center, Dallas, TX, USA.
Wehweck FS; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Li J; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Stein S; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Gerke JS; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Baldauf MC; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Musa J; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Dallmayer M; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Romero-Pérez L; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; Hopp-Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Hölting TLB; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Amatruda JF; Department of Pediatrics and Molecular Biology, University of Texas Southwestern Medical Center and Children's Medical Center, Dallas, TX, USA.; Children's Hospital of Los Angeles, Los Angeles, CA, USA.
Cossarizza A; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Modena, Italy.
Henssen AG; Department of Pediatrics, Division of Oncology and Hematology, Charité Berlin, Berlin, Germany.; Berlin Institute of Health, Berlin, Germany.; Experimental and Clinical Research Center (ECRC) of the MDC and Charité Berlin, Berlin, Germany.; German Cancer Consortium (DKTK), partner site, Berlin, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.
Kirchner T; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), partner site, Munich, Germany.
Moretti M; Regenerative Medicine Technologies Laboratory, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland.
Cidre-Aranaz F; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; Hopp-Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Sannino G; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Grünewald TGP; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany. .; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany. .; Hopp-Children's Cancer Center (KiTZ), Heidelberg, Germany. .; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. .; German Cancer Consortium (DKTK), partner site, Munich, Germany. .; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany. .
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Źródło :
Nature communications [Nat Commun] 2020 May 15; Vol. 11 (1), pp. 2423. Date of Electronic Publication: 2020 May 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Oxidative Stress*
Oncogene Proteins, Fusion/*metabolism
Sarcoma, Ewing/*pathology
Adult ; Animals ; Bone Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation ; Child ; Chondrocytes/metabolism ; DNA Methylation ; Enhancer Elements, Genetic ; Gene Expression Profiling ; HEK293 Cells ; Humans ; Hydrazines/chemistry ; Mesenchymal Stem Cells/metabolism ; Mice ; Microsatellite Repeats ; Mitochondria/metabolism ; Oligonucleotide Array Sequence Analysis ; Oncogenes ; RNA Interference ; SOXD Transcription Factors/metabolism ; Sarcoma/genetics
Czasopismo naukowe
Tytuł :
Integrative clinical transcriptome analysis reveals TMPRSS2-ERG dependency of prognostic biomarkers in prostate adenocarcinoma.
Autorzy :
Gerke JS; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Orth MF; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Tolkach Y; Institute of Pathology, University Hospital Bonn, Bonn, Germany.
Romero-Pérez L; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Wehweck FS; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Stein S; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Musa J; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Knott MML; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Hölting TLB; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Li J; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Sannino G; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Marchetto A; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Ohmura S; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Cidre-Aranaz F; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Munich, Germany.; Department of Internal Medicine I (Cardiology), Hospital of the LMU Munich, Munich, Germany.
Strauch K; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany.
Stief C; Urologic Clinic und Polyclinic, Clinical Center of the University of Munich, Munich, Germany.
Kristiansen G; Institute of Pathology, University Hospital Bonn, Bonn, Germany.
Kirchner T; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; German Cancer Consortium (DKTK), partner site Munich, Munich, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.
Buchner A; Department of Internal Medicine I (Cardiology), Hospital of the LMU Munich, Munich, Germany.
Grünewald TGP; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; German Cancer Consortium (DKTK), partner site Munich, Munich, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.
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Źródło :
International journal of cancer [Int J Cancer] 2020 Apr 01; Vol. 146 (7), pp. 2036-2046. Date of Electronic Publication: 2019 Nov 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biomarkers, Tumor*
Adenocarcinoma/*genetics
Adenocarcinoma/*mortality
Oncogene Proteins, Fusion/*genetics
Prostatic Neoplasms/*genetics
Prostatic Neoplasms/*mortality
Adenocarcinoma/diagnosis ; Computational Biology ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Male ; Neoplasm Grading ; Neoplasm Metastasis ; Neoplasm Staging ; Prognosis ; Prostatic Neoplasms/diagnosis
Czasopismo naukowe
Tytuł :
Pan-Cancer Analysis of Mitochondria Chaperone-Client Co-Expression Reveals Chaperone Functional Partitioning.
Autorzy :
Galai G; Department of Life Sciences, Ben-Gurion University of the Negev, Beer Sheva 8410501, Israel.; The National Institute for Biotechnology in the Negev, Beer Sheva 8410501, Israel.
Ben-David H; Department of Life Sciences, Ben-Gurion University of the Negev, Beer Sheva 8410501, Israel.; The National Institute for Biotechnology in the Negev, Beer Sheva 8410501, Israel.
Levin L; The National Institute for Biotechnology in the Negev, Beer Sheva 8410501, Israel.
Orth MF; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology of the LMU Munich, 80337 Munich, Germany.
Grünewald TGP; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology of the LMU Munich, 80337 Munich, Germany.; Institute of Pathology of the LMU Munich, 80337 Munich, Germany.; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany.; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.
Pilosof S; Department of Life Sciences, Ben-Gurion University of the Negev, Beer Sheva 8410501, Israel.
Berstein S; Department of Life Sciences, Ben-Gurion University of the Negev, Beer Sheva 8410501, Israel.
Rotblat B; Department of Life Sciences, Ben-Gurion University of the Negev, Beer Sheva 8410501, Israel.; The National Institute for Biotechnology in the Negev, Beer Sheva 8410501, Israel.
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Źródło :
Cancers [Cancers (Basel)] 2020 Mar 30; Vol. 12 (4). Date of Electronic Publication: 2020 Mar 30.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
High Specificity of BCL11B and GLG1 for EWSR1-FLI1 and EWSR1-ERG Positive Ewing Sarcoma.
Autorzy :
Orth MF; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.
Hölting TLB; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.
Dallmayer M; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.; Department of Pediatrics, University Hospital Münster, 48149 Münster, Germany.
Wehweck FS; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.; Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.
Paul T; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.; Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.
Musa J; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.; Department of General, Visceral and Transplantation Surgery, University of Heidelberg, 69120 Heidelberg, Germany.
Baldauf MC; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.
Surdez D; INSERM Unit 830 'Genetics and Biology of Cancers', Institut Curie Research Center, 75248 Paris, France.
Delattre O; INSERM Unit 830 'Genetics and Biology of Cancers', Institut Curie Research Center, 75248 Paris, France.
Knott MML; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.; Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.
Romero-Pérez L; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.
Kasan M; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.
Cidre-Aranaz F; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.
Gerke JS; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.
Ohmura S; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.
Li J; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.
Marchetto A; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.
Henssen AG; Department of Pediatric Hematology/Oncology/BMT, Charité-University Medicine Berlin, 13353 Berlin, Germany.; Experimental and Clinical Research Center (ECRC) of the MDC and Charité Berlin, 13125 Berlin, Germany.
Özen Ö; Department of Pathology, Başkent University Hospital, 06490 Ankara, Turkey.
Sugita S; Department of Surgical Pathology, Sapporo Medical University, 060-8556 Sapporo, Japan.
Hasegawa T; Department of Surgical Pathology, Sapporo Medical University, 060-8556 Sapporo, Japan.
Kanaseki T; Department of Pathology, Sapporo Medical University, 060-8556 Sapporo, Japan.
Bertram S; Institute of Pathology, University Hospital Essen, 45147 Essen, Germany.
Dirksen U; Pediatrics III, AYA Unit, West German Cancer Centre, University Hospital Essen, 45147 Essen, Germany.; German Cancer Consortium (DKTK), Partner site Essen, 45147 Essen, Germany.
Hartmann W; Division of Translational Oncology, Gerhard-Domagk-Institute for Pathology, University Hospital Münster, 48149 Münster, Germany.
Kirchner T; Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.; German Cancer Consortium (DKTK), Partner site Munich, 80336 Munich, Germany.; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Grünewald TGP; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.; Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.; German Cancer Consortium (DKTK), Partner site Munich, 80336 Munich, Germany.; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
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Źródło :
Cancers [Cancers (Basel)] 2020 Mar 10; Vol. 12 (3). Date of Electronic Publication: 2020 Mar 10.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Knockout of LASP1 in CXCR4 expressing CML cells promotes cell persistence, proliferation and TKI resistance.
Autorzy :
Herrmann AB; Institut für Experimentelle Biomedizin II, Universitätsklinikum Würzburg, Würzburg, Germany.
Müller ML; Rudolf-Virchow-Zentrum für Experimentelle Biomedizin I, Universitätsklinikum Würzburg, Würzburg, Germany.
Orth MF; Labor für Pädiatrische Sarkombiologie, Medizinische Fakultät, Pathologisches Institut, LMU München, München, Germany.
Müller JP; Center for Molecular Biomedicine, Institut für Molekulare Zellbiologie, Universitätsklinikum Jena, Jena, Germany.
Zernecke A; Institut für Experimentelle Biomedizin II, Universitätsklinikum Würzburg, Würzburg, Germany.
Hochhaus A; Abteilung für Hämatologie und internistische Onkologie, Klinik für Innere Medizin II, Universitätsklinikum Jena, Jena, Germany.
Ernst T; Abteilung für Hämatologie und internistische Onkologie, Klinik für Innere Medizin II, Universitätsklinikum Jena, Jena, Germany.
Butt E; Institut für Experimentelle Biomedizin II, Universitätsklinikum Würzburg, Würzburg, Germany.
Frietsch JJ; Abteilung für Hämatologie und internistische Onkologie, Klinik für Innere Medizin II, Universitätsklinikum Jena, Jena, Germany.
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Źródło :
Journal of cellular and molecular medicine [J Cell Mol Med] 2020 Mar; Vol. 24 (5), pp. 2942-2955. Date of Electronic Publication: 2020 Jan 19.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Focal adhesion kinase confers pro-migratory and antiapoptotic properties and is a potential therapeutic target in Ewing sarcoma.
Autorzy :
Steinestel K; Gerhard Domagk Institute of Pathology, University Hospital Münster, Germany.; Institute of Pathology and Molecular Pathology, Bundeswehrkrankenhaus Ulm, Germany.
Trautmann M; Gerhard Domagk Institute of Pathology, University Hospital Münster, Germany.; Division of Translational Pathology, Gerhard-Domagk-Institute of Pathology, University Hospital Münster, Germany.
Jansen EP; Gerhard Domagk Institute of Pathology, University Hospital Münster, Germany.
Dirksen U; Pediatrics III, West German Cancer Centre, University Hospital Essen, Germany.
Rehkämper J; Institute of Pathology, University Hospital Cologne, Germany.
Mikesch JH; Department of Medicine A, University Hospital Münster, Germany.
Gerke JS; Max Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Germany.
Orth MF; Max Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Germany.
Sannino G; Max Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Germany.
Arteaga MF; Department of Medicine A, University Hospital Münster, Germany.
Rossig C; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Germany.
Wardelmann E; Gerhard Domagk Institute of Pathology, University Hospital Münster, Germany.
Grünewald TGP; Max Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Germany.; German Cancer Consortium (DKTK), Partner Site Munich, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Institute of Pathology, Faculty of Medicine, LMU Munich, Germany.
Hartmann W; Gerhard Domagk Institute of Pathology, University Hospital Münster, Germany.; Division of Translational Pathology, Gerhard-Domagk-Institute of Pathology, University Hospital Münster, Germany.
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Źródło :
Molecular oncology [Mol Oncol] 2020 Feb; Vol. 14 (2), pp. 248-260. Date of Electronic Publication: 2019 Dec 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Czasopismo naukowe
Tytuł :
Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes.
Autorzy :
Musa J; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Cidre-Aranaz F; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Aynaud MM; INSERM U830, Équipe Labellisée LNCC Genetics and Biology of Pediatric Cancers, PSL Research University, SIREDO Oncology Centre, Institut Curie Research Centre, Paris, France.
Orth MF; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Knott MML; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Mirabeau O; INSERM U830, Équipe Labellisée LNCC Genetics and Biology of Pediatric Cancers, PSL Research University, SIREDO Oncology Centre, Institut Curie Research Centre, Paris, France.
Mazor G; Department of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Varon M; Department of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Hölting TLB; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Grossetête S; INSERM U830, Équipe Labellisée LNCC Genetics and Biology of Pediatric Cancers, PSL Research University, SIREDO Oncology Centre, Institut Curie Research Centre, Paris, France.
Gartlgruber M; Neuroblastoma Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Surdez D; INSERM U830, Équipe Labellisée LNCC Genetics and Biology of Pediatric Cancers, PSL Research University, SIREDO Oncology Centre, Institut Curie Research Centre, Paris, France.
Gerke JS; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Ohmura S; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Marchetto A; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Dallmayer M; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Baldauf MC; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Stein S; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Sannino G; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Li J; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Romero-Pérez L; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Westermann F; Neuroblastoma Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Hartmann W; Division of Translational Pathology, Gerhard-Domagk Institute of Pathology, University Hospital of Münster, Münster, Germany.
Dirksen U; Department of Pediatric Hematology and Oncology, University Hospital of Essen, Essen, Germany.
Gymrek M; Department of Medicine, University of California, San Diego, La Jolla, CA, USA.; Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CA, USA.
Anderson ND; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Shlien A; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada.
Rotblat B; Department of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Kirchner T; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; German Cancer Consortium (DKTK), Partner site Munich, Munich, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.
Delattre O; INSERM U830, Équipe Labellisée LNCC Genetics and Biology of Pediatric Cancers, PSL Research University, SIREDO Oncology Centre, Institut Curie Research Centre, Paris, France.
Grünewald TGP; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany. .; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany. .; German Cancer Consortium (DKTK), Partner site Munich, Munich, Germany. .; German Cancer Research Center (DKFZ), Heidelberg, Germany. .
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Źródło :
Nature communications [Nat Commun] 2019 Sep 11; Vol. 10 (1), pp. 4128. Date of Electronic Publication: 2019 Sep 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Germ-Line Mutation/*genetics
Neoplasms/*genetics
Neoplasms/*therapy
Animals ; Cell Cycle Proteins ; Cell Line, Tumor ; Cell Proliferation ; Cell Survival ; Cyclin-Dependent Kinase 2/antagonists & inhibitors ; Cyclin-Dependent Kinase 2/metabolism ; Gene Expression Regulation, Neoplastic ; HEK293 Cells ; Humans ; Mice ; Microsatellite Repeats/genetics ; Neoplasm Proteins/metabolism ; Oncogene Proteins, Fusion/metabolism ; Phenotype ; Polymorphism, Genetic ; Trans-Activators ; Treatment Outcome ; Up-Regulation/genetics
Czasopismo naukowe
Tytuł :
Gene expression and immunohistochemical analyses identify SOX2 as major risk factor for overall survival and relapse in Ewing sarcoma patients.
Autorzy :
Sannino G; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Marchetto A; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Ranft A; Department of Pediatrics III, West German Cancer Centre, University Hospital Essen, Essen, Germany.
Jabar S; Department of Pediatrics III, West German Cancer Centre, University Hospital Essen, Essen, Germany.
Zacherl C; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Alba-Rubio R; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Stein S; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Wehweck FS; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Kiran MM; Department of Pathology, Medical Faculty, Ankara Yildirim Beyazit University, Ankara, Turkey.
Hölting TLB; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Musa J; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Romero-Pérez L; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Cidre-Aranaz F; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Knott MML; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Li J; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Jürgens H; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany.
Sastre A; Unidad hemato-oncología pediátrica, Hospital Infantil Universitario La Paz, Madrid, Spain.
Alonso J; Pediatric Solid Tumour Laboratory, Institute of Rare Diseases Research (IIER), Instituto de Salud Carlos III, Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras, Instituto de Salud Carlos III (CB06/07/1009; CIBERER-ISCIII), Spain.
Da Silveira W; Center for Genomics Medicine, Medical University of South Carolina, Charleston, SC, USA.
Hardiman G; Center for Genomics Medicine, Medical University of South Carolina, Charleston, SC, USA; School of Biological Sciences, Institute for Global Food Security, Queen's University Belfast, Belfast, UK.
Gerke JS; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Orth MF; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Hartmann W; Gerhard-Domagk Institute of Pathology, University Hospital of Münster, Münster, Germany.
Kirchner T; Institute of Pathology, Faculty of Medicine, LMU Munich, Germany; German Cancer Consortium (DKTK), partner site Munich, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany.
Ohmura S; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Dirksen U; Department of Pediatrics III, West German Cancer Centre, University Hospital Essen, Essen, Germany; German Cancer Consortium (DKTK), partner site Essen, Germany. Electronic address: .
Grünewald TGP; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany; German Cancer Consortium (DKTK), partner site Munich, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: .
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Źródło :
EBioMedicine [EBioMedicine] 2019 Sep; Vol. 47, pp. 156-162. Date of Electronic Publication: 2019 Aug 16.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression*
SOXB1 Transcription Factors/*genetics
SOXB1 Transcription Factors/*metabolism
Sarcoma, Ewing/*genetics
Sarcoma, Ewing/*metabolism
Biomarkers ; Biomarkers, Tumor ; Female ; Humans ; Immunohistochemistry ; Male ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Prognosis ; Risk Factors ; Sarcoma, Ewing/diagnosis ; Sarcoma, Ewing/mortality
Czasopismo naukowe
Tytuł :
Functional genomics identifies AMPD2 as a new prognostic marker for undifferentiated pleomorphic sarcoma.
Autorzy :
Orth MF; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Gerke JS; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Knösel T; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Altendorf-Hofmann A; Department of General, Visceral and Vascular Surgery, Jena University Hospital, Jena, Germany.
Musa J; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Alba-Rubio R; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Stein S; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Hölting TLB; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Cidre-Aranaz F; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Romero-Pérez L; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Dallmayer M; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Baldauf MC; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Marchetto A; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Sannino G; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Knott MML; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Wehweck F; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Ohmura S; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Li J; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Hakozaki M; Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan.
Kirchner T; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; German Cancer Consortium (DKTK), partner site Munich, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.
Dandekar T; Functional Genomics and Systems Biology Group, Department of Bioinformatics, Biocenter, Am Hubland, Würzburg, Germany.
Butt E; Institute for Experimental Biomedicine II, University Clinic of Würzburg, Würzburg, Germany.
Grünewald TGP; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; German Cancer Consortium (DKTK), partner site Munich, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.
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Źródło :
International journal of cancer [Int J Cancer] 2019 Feb 15; Vol. 144 (4), pp. 859-867. Date of Electronic Publication: 2018 Dec 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
AMP Deaminase/*genetics
Biomarkers, Tumor/*genetics
Genomics/*methods
Histiocytoma, Malignant Fibrous/*genetics
AMP Deaminase/metabolism ; Adult ; Aged ; Aged, 80 and over ; Animals ; Biomarkers, Tumor/metabolism ; Cell Line, Tumor ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Histiocytoma, Malignant Fibrous/metabolism ; Histiocytoma, Malignant Fibrous/pathology ; Humans ; Kaplan-Meier Estimate ; Mice, Inbred NOD ; Mice, Knockout ; Mice, SCID ; Middle Aged ; Prognosis ; RNAi Therapeutics/methods ; Xenograft Model Antitumor Assays/methods ; Young Adult
Czasopismo naukowe
Tytuł :
Targeting the CALCB/RAMP1 axis inhibits growth of Ewing sarcoma.
Autorzy :
Dallmayer M; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology of the LMU Munich, Munich, Germany.
Li J; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology of the LMU Munich, Munich, Germany.
Ohmura S; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology of the LMU Munich, Munich, Germany.
Alba Rubio R; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology of the LMU Munich, Munich, Germany.
Baldauf MC; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology of the LMU Munich, Munich, Germany.
Hölting TLB; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology of the LMU Munich, Munich, Germany.
Musa J; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology of the LMU Munich, Munich, Germany.
Knott MML; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology of the LMU Munich, Munich, Germany.; Institute of Pathology of the LMU Munich, Munich, Germany.
Stein S; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology of the LMU Munich, Munich, Germany.
Cidre-Aranaz F; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology of the LMU Munich, Munich, Germany.
Wehweck FS; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology of the LMU Munich, Munich, Germany.; Institute of Pathology of the LMU Munich, Munich, Germany.
Romero-Pérez L; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology of the LMU Munich, Munich, Germany.
Gerke JS; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology of the LMU Munich, Munich, Germany.
Orth MF; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology of the LMU Munich, Munich, Germany.
Marchetto A; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology of the LMU Munich, Munich, Germany.
Kirchner T; Institute of Pathology of the LMU Munich, Munich, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.
Bach H; Department of Medicine, Division of Infectious Diseases, and IIRC Antibody Engineering and Proteomics facility, University of British Columbia, Vancouver, BC, Canada.
Sannino G; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology of the LMU Munich, Munich, Germany.
Grünewald TGP; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology of the LMU Munich, Munich, Germany. .; Institute of Pathology of the LMU Munich, Munich, Germany. .; German Cancer Consortium (DKTK), Heidelberg, Germany. .; German Cancer Research Center (DKFZ), Heidelberg, Germany. .
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Źródło :
Cell death & disease [Cell Death Dis] 2019 Feb 11; Vol. 10 (2), pp. 116. Date of Electronic Publication: 2019 Feb 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcitonin Gene-Related Peptide/*metabolism
Receptor Activity-Modifying Protein 1/*metabolism
Sarcoma, Ewing/*pathology
Animals ; Calcitonin Gene-Related Peptide/antagonists & inhibitors ; Calcitonin Gene-Related Peptide/genetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Gene Expression Regulation, Neoplastic ; Humans ; Mice ; Mice, Inbred NOD ; Microsatellite Repeats/genetics ; RNA Interference ; RNA, Small Interfering/metabolism ; RNA, Small Interfering/therapeutic use ; Receptor Activity-Modifying Protein 1/antagonists & inhibitors ; Receptor Activity-Modifying Protein 1/genetics ; Sarcoma, Ewing/drug therapy ; Sarcoma, Ewing/metabolism ; Small Molecule Libraries/pharmacology ; Transplantation, Heterologous
Czasopismo naukowe
Tytuł :
Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity.
Autorzy :
Vriens K; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.
Christen S; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.
Parik S; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.; Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium.; Myeloid Cell Immunology Laboratory, VIB Center for Inflammation Research, Brussels, Belgium.
Broekaert D; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.
Yoshinaga K; Tsukishima Foods Industry, Tokyo, Japan.; Cluster of Agricultural Sciences, Faculty of Food and Agricultural Sciences, Fukushima University, Fukushima, Japan.
Talebi A; Laboratory of Lipid Metabolism and Cancer, Department of Oncology, Leuven Cancer Institute (LKI), Leuven, Belgium.
Dehairs J; Laboratory of Lipid Metabolism and Cancer, Department of Oncology, Leuven Cancer Institute (LKI), Leuven, Belgium.
Escalona-Noguero C; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.
Schmieder R; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.
Cornfield T; The Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK.
Charlton C; The Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK.
Romero-Pérez L; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Rossi M; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.
Rinaldi G; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.
Orth MF; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Boon R; Stem Cell Institute, Department of Development and Regeneration, KU Leuven, Leuven, Belgium.
Kerstens A; VIB Bio Imaging Core and VIB-KU Leuven Center for Brain & Disease Research, KU Leuven, Leuven, Belgium.; Molecular Neurobiology, Department of Neuroscience, KU Leuven, Leuven, Belgium.
Kwan SY; Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Faubert B; Children's Medical Center Research Institute, UT Southwestern, Dallas, TX, USA.
Méndez-Lucas A; The Francis Crick Institute, London, UK.
Kopitz CC; Bayer AG, Research & Development, Pharmaceuticals, Berlin, Germany.
Chen T; Perlmutter Cancer Center, NYU Langone Medical Center, Smilow Research Center, New York, NY, USA.
Fernandez-Garcia J; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.
Duarte JAG; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.
Schmitz AA; Bayer AG, Research & Development, Pharmaceuticals, Berlin, Germany.
Steigemann P; Bayer AG, Research & Development, Pharmaceuticals, Berlin, Germany.
Najimi M; Laboratory of Pediatric Hepatology and Cell Therapy, Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain and Cliniques Universitaires St Luc, Brussels, Belgium.
Hägebarth A; Bayer AG, Research & Development, Pharmaceuticals, Berlin, Germany.
Van Ginderachter JA; Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium.; Myeloid Cell Immunology Laboratory, VIB Center for Inflammation Research, Brussels, Belgium.
Sokal E; Laboratory of Pediatric Hepatology and Cell Therapy, Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain and Cliniques Universitaires St Luc, Brussels, Belgium.
Gotoh N; Department of Food Science and Technology, Tokyo University of Marine Science and Technology, Tokyo, Japan.
Wong KK; Perlmutter Cancer Center, NYU Langone Medical Center, Smilow Research Center, New York, NY, USA.
Verfaillie C; Stem Cell Institute, Department of Development and Regeneration, KU Leuven, Leuven, Belgium.
Derua R; Laboratory of Protein Phosphorylation and Proteomics, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
Munck S; VIB Bio Imaging Core and VIB-KU Leuven Center for Brain & Disease Research, KU Leuven, Leuven, Belgium.; Molecular Neurobiology, Department of Neuroscience, KU Leuven, Leuven, Belgium.
Yuneva M; The Francis Crick Institute, London, UK.
Beretta L; Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
DeBerardinis RJ; Children's Medical Center Research Institute, UT Southwestern, Dallas, TX, USA.; Howard Hughes Medical Institute, UT Southwestern Medical Center, Dallas, TX, USA.
Swinnen JV; Laboratory of Lipid Metabolism and Cancer, Department of Oncology, Leuven Cancer Institute (LKI), Leuven, Belgium.
Hodson L; The Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK.
Cassiman D; Department of Hepatology, KU Leuven, Leuven, Belgium.; Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium.
Verslype C; Department of Hepatology, KU Leuven, Leuven, Belgium.; Department of Digestive Oncology, KU Leuven, Leuven, Belgium.
Christian S; Bayer AG, Research & Development, Pharmaceuticals, Berlin, Germany.
Grünewald S; Bayer AG, Research & Development, Pharmaceuticals, Berlin, Germany.
Grünewald TGP; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; German Cancer Consortium (DKTK), Partner site Munich, Munich, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.
Fendt SM; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium. .; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium. .
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Źródło :
Nature [Nature] 2019 Feb; Vol. 566 (7744), pp. 403-406. Date of Electronic Publication: 2019 Feb 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Metabolic Networks and Pathways*
Fatty Acids/*chemistry
Fatty Acids/*metabolism
Neoplasms/*metabolism
Neoplasms/*pathology
Animals ; Cell Line, Tumor ; Cell Membrane/metabolism ; Cell Proliferation ; Fatty Acid Desaturases/metabolism ; Female ; HEK293 Cells ; Humans ; Male ; Mice ; Oleic Acids/metabolism ; Palmitates/metabolism ; Palmitic Acids/metabolism ; Stearoyl-CoA Desaturase/metabolism
Czasopismo naukowe
Tytuł :
Systematic identification of cancer-specific MHC-binding peptides with RAVEN.
Autorzy :
Baldauf MC; Faculty of Medicine, Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, LMU Munich, Munich, Germany.
Gerke JS; Faculty of Medicine, Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, LMU Munich, Munich, Germany.
Kirschner A; Children's Cancer Research Center, Technische Universität München (TUM), Munich, Germany.
Blaeschke F; Department of Pediatrics, Dr. von Hauner'sches Children's Hospital, LMU Munich, Munich, Germany.
Effenberger M; Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), Munich, Germany.
Schober K; Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), Munich, Germany.
Rubio RA; Faculty of Medicine, Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, LMU Munich, Munich, Germany.
Kanaseki T; Department of Pathology, Sapporo Medical University, Sapporo, Japan.
Kiran MM; Department of Pathology, Medical Faculty, Yildirim Beyazit University, Ankara, Turkey.
Dallmayer M; Faculty of Medicine, Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, LMU Munich, Munich, Germany.
Musa J; Faculty of Medicine, Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, LMU Munich, Munich, Germany.
Akpolat N; Department of Pathology, Turgut Ozal Medical Center, Inonu University, Malatya, Turkey.
Akatli AN; Department of Pathology, Turgut Ozal Medical Center, Inonu University, Malatya, Turkey.
Rosman FC; Department for Pathology, Hospital Municipal Jesus, Rio de Janeiro, Brazil.
Özen Ö; Department of Pathology, Medical Faculty, Başkent University Hospital, Ankara, Turkey.
Sugita S; Department of Pathology, Sapporo Medical University, Sapporo, Japan.
Hasegawa T; Department of Pathology, Sapporo Medical University, Sapporo, Japan.
Sugimura H; Department of Tumor Pathology, Hamamatsu School of Medicine, Hamamatsu, Japan.
Baumhoer D; Bone Tumor Reference Center, Institute of Pathology of the University Hospital of Basel, Basel, Switzerland.
Knott MML; Faculty of Medicine, Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, LMU Munich, Munich, Germany.
Sannino G; Faculty of Medicine, Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, LMU Munich, Munich, Germany.
Marchetto A; Faculty of Medicine, Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, LMU Munich, Munich, Germany.
Li J; Faculty of Medicine, Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, LMU Munich, Munich, Germany.
Busch DH; Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), Munich, Germany.
Feuchtinger T; Department of Pediatrics, Dr. von Hauner'sches Children's Hospital, LMU Munich, Munich, Germany.
Ohmura S; Faculty of Medicine, Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, LMU Munich, Munich, Germany.
Orth MF; Faculty of Medicine, Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, LMU Munich, Munich, Germany.
Thiel U; Children's Cancer Research Center, Technische Universität München (TUM), Munich, Germany.
Kirchner T; Faculty of Medicine, Institute of Pathology, LMU Munich, Munich, Germany.; German Cancer Consortium (DKTK), Partner Site Munich, Heidelberg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.
Grünewald TGP; Faculty of Medicine, Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, LMU Munich, Munich, Germany.; Faculty of Medicine, Institute of Pathology, LMU Munich, Munich, Germany.; German Cancer Consortium (DKTK), Partner Site Munich, Heidelberg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.
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Źródło :
Oncoimmunology [Oncoimmunology] 2018 Jul 23; Vol. 7 (9), pp. e1481558. Date of Electronic Publication: 2018 Jul 23 (Print Publication: 2018).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Are EWSR1-NFATc2-positive sarcomas really Ewing sarcomas?
Autorzy :
Baldauf MC; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Gerke JS; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Orth MF; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Dallmayer M; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Baumhoer D; Bone Tumour Reference Center, Institute of Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.
de Alava E; Institute of Biomedicine of Seville (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, CIBERONC, Seville, Spain.
Hartmann W; Gerhard-Domagk-Institute for Pathology, University Hospital Münster, Westfalian Wilhelms University, Münster, Germany.
Kirchner T; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.
Grünewald TGP; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany. .; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany. .; German Cancer Consortium (DKTK), Heidelberg, Germany. .; German Cancer Research Center (DKFZ), Heidelberg, Germany. .
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Źródło :
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc [Mod Pathol] 2018 Jun; Vol. 31 (6), pp. 997-999. Date of Electronic Publication: 2018 Jun 12.
Typ publikacji :
Letter; Comment
MeSH Terms :
NFATC Transcription Factors*
Sarcoma, Ewing*
Humans ; PAX7 Transcription Factor ; RNA-Binding Protein EWS
Opinia redakcyjna
Tytuł :
Heterogeneity of neuroblastoma cell identity defined by transcriptional circuitries.
Autorzy :
Boeva V; Institut Curie, Paris Sciences et Lettres (PSL) Research University, INSERM, U900, Mines-ParisTech, Paris, France.; Institut Cochin, Inserm U1016, Centre National de la Recherche Scientifique (CNRS), Unité Mixte de Recherche (UMR) 8104, University Paris Descartes UMR-S1016, Paris, France.
Louis-Brennetot C; Institut Curie, PSL Research University, INSERM, U830, Equipe Labellisée Ligue contre le Cancer, Paris, France.
Peltier A; Institut Curie, PSL Research University, INSERM, U830, Equipe Labellisée Ligue contre le Cancer, Paris, France.
Durand S; Institut Curie, PSL Research University, INSERM, U830, Equipe Labellisée Ligue contre le Cancer, Paris, France.
Pierre-Eugène C; Institut Curie, PSL Research University, INSERM, U830, Equipe Labellisée Ligue contre le Cancer, Paris, France.
Raynal V; Institut Curie, PSL Research University, INSERM, U830, Equipe Labellisée Ligue contre le Cancer, Paris, France.; Institut Curie Genomics of Excellence (ICGex) Platform, Institut Curie Research Center, Paris, France.
Etchevers HC; Aix Marseille University, INSERM, Génétique Médicale et Génomique Fonctionnelle (GMGF) UMR S910, Marseille, France.
Thomas S; INSERM U1163, Laboratory of Embryology and Genetics of Congenital Malformations, Paris Descartes - Sorbonne Paris Cité University, Imagine Institute, Paris, France.
Lermine A; Institut Curie, Paris Sciences et Lettres (PSL) Research University, INSERM, U900, Mines-ParisTech, Paris, France.
Daudigeos-Dubus E; Gustave Roussy, Vectorology and Anticancer Therapies, UMR 8203, CNRS, Université Paris-Sud, Université Paris-Saclay, Villejuif, France.
Geoerger B; Gustave Roussy, Vectorology and Anticancer Therapies, UMR 8203, CNRS, Université Paris-Sud, Université Paris-Saclay, Villejuif, France.
Orth MF; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Ludwig-Maximilians-Universität München (LMU), Munich, Germany.
Grünewald TGP; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Ludwig-Maximilians-Universität München (LMU), Munich, Germany.
Diaz E; High Throughput qPCR Facility, Institut de Biologie de l'École Normale Supérieure (IBENS), PSL Research University, Paris, France.; LPS-ENS, Université Pierre et Marie Curie (UPMC), Université Denis Diderot, CNRS UMR 8550, PSL, Paris, France.
Ducos B; High Throughput qPCR Facility, Institut de Biologie de l'École Normale Supérieure (IBENS), PSL Research University, Paris, France.; LPS-ENS, Université Pierre et Marie Curie (UPMC), Université Denis Diderot, CNRS UMR 8550, PSL, Paris, France.; Laser Microdissection Facility, Center for Interdisciplinary Research in Biology (CIRB) Collège de France, Paris, France.
Surdez D; Institut Curie, PSL Research University, INSERM, U830, Equipe Labellisée Ligue contre le Cancer, Paris, France.
Carcaboso AM; Institut de Recerca Sant Joan de Deu, Barcelona, Spain.
Medvedeva I; Institut Cochin, Inserm U1016, Centre National de la Recherche Scientifique (CNRS), Unité Mixte de Recherche (UMR) 8104, University Paris Descartes UMR-S1016, Paris, France.
Deller T; Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University Frankfurt, Frankfurt am Main, Germany.
Combaret V; Centre Léon Bérard, Laboratoire de Recherche Translationnelle, Lyon, France.
Lapouble E; Institut Curie, Unité de Génétique Somatique, Paris, France.
Pierron G; Institut Curie, Unité de Génétique Somatique, Paris, France.
Grossetête-Lalami S; Institut Curie, PSL Research University, INSERM, U830, Equipe Labellisée Ligue contre le Cancer, Paris, France.
Baulande S; Institut Curie Genomics of Excellence (ICGex) Platform, Institut Curie Research Center, Paris, France.
Schleiermacher G; Institut Curie, PSL Research University, INSERM, U830, Equipe Labellisée Ligue contre le Cancer, Paris, France.; Laboratory Recherche Translationnelle en Oncologie Pédiatrique (RTOP), Laboratoire 'Gilles Thomas', Institut Curie, Paris, France.; Department of Translational Research, Institut Curie, Paris, France.; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.
Barillot E; Institut Curie, Paris Sciences et Lettres (PSL) Research University, INSERM, U900, Mines-ParisTech, Paris, France.
Rohrer H; Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University Frankfurt, Frankfurt am Main, Germany.
Delattre O; Institut Curie, PSL Research University, INSERM, U830, Equipe Labellisée Ligue contre le Cancer, Paris, France.; Institut Curie Genomics of Excellence (ICGex) Platform, Institut Curie Research Center, Paris, France.; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.
Janoueix-Lerosey I; Institut Curie, PSL Research University, INSERM, U830, Equipe Labellisée Ligue contre le Cancer, Paris, France.; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.
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Źródło :
Nature genetics [Nat Genet] 2017 Sep; Vol. 49 (9), pp. 1408-1413. Date of Electronic Publication: 2017 Jul 24.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Lineage/*genetics
Gene Expression Regulation, Neoplastic/*genetics
Neuroblastoma/*genetics
Transcription Factors/*genetics
Animals ; Blotting, Western ; Cell Line, Tumor/classification ; Cell Lineage/drug effects ; Doxycycline/pharmacology ; Gene Expression Profiling/methods ; Gene Expression Regulation, Neoplastic/drug effects ; Genetic Heterogeneity ; HEK293 Cells ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Humans ; Mice, Inbred NOD ; Mice, Knockout ; Mice, SCID ; Neuroblastoma/drug therapy ; Neuroblastoma/metabolism ; RNA Interference ; RNAi Therapeutics ; Reverse Transcriptase Polymerase Chain Reaction ; Single-Cell Analysis ; Transcription Factors/metabolism ; Xenograft Model Antitumor Assays/methods
Czasopismo naukowe
Tytuł :
Robust diagnosis of Ewing sarcoma by immunohistochemical detection of super-enhancer-driven EWSR1-ETS targets.
Autorzy :
Baldauf MC; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Orth MF; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Dallmayer M; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Marchetto A; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Gerke JS; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Rubio RA; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Kiran MM; Department of Pathology, Medical Faculty, Ankara Yildirim Beyazit University, Ankara, Turkey.
Musa J; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Knott MML; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Ohmura S; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Li J; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Akpolat N; Department of Pathology, Turgut Ozal Medical Center, Inonu University, Malatya, Turkey.
Akatli AN; Department of Pathology, Turgut Ozal Medical Center, Inonu University, Malatya, Turkey.
Özen Ö; Department of Pathology, Başkent University Hospital, Ankara, Turkey.
Dirksen U; Department of Pediatric Hematology and Oncology, University Hospital Essen, Essen, Germany.
Hartmann W; Gerhard-Domagk-Institute for Pathology, University Hospital Münster, Westfalian Wilhelms University, Münster, Germany.
de Alava E; Institute of Biomedicine of Seville (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, CIBERONC, Seville, Spain.
Baumhoer D; Bone Tumour Reference Center, Institute of Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.
Sannino G; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Kirchner T; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.
Grünewald TGP; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.
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Źródło :
Oncotarget [Oncotarget] 2017 Aug 04; Vol. 9 (2), pp. 1587-1601. Date of Electronic Publication: 2017 Aug 04 (Print Publication: 2018).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Next steps in Ewing sarcoma (epi-)genomics.
Autorzy :
Sannino G; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, LMU Munich, Germany.
Orth MF; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, LMU Munich, Germany.
Grünewald TG; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, LMU Munich, Germany.
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Źródło :
Future oncology (London, England) [Future Oncol] 2017 Jun; Vol. 13 (14), pp. 1207-1211. Date of Electronic Publication: 2017 Jun 07.
Typ publikacji :
Editorial
MeSH Terms :
DNA Copy Number Variations/*genetics
Oncogene Proteins, Fusion/*genetics
RNA-Binding Protein EWS/*genetics
Sarcoma, Ewing/*genetics
Antigens, Nuclear/genetics ; Antigens, Protozoan/genetics ; Cyclin-Dependent Kinase Inhibitor p16 ; Cyclin-Dependent Kinase Inhibitor p18/genetics ; Epigenomics ; Germ-Line Mutation ; Humans ; Sarcoma, Ewing/pathology
Opinia redakcyjna
Tytuł :
Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells.
Autorzy :
Elia I; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Herestraat 49, Leuven 3000, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Herestraat 49, Leuven 3000, Belgium.
Broekaert D; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Herestraat 49, Leuven 3000, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Herestraat 49, Leuven 3000, Belgium.
Christen S; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Herestraat 49, Leuven 3000, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Herestraat 49, Leuven 3000, Belgium.
Boon R; Stem Cell Institute, KU Leuven, Herestraat 49, Leuven 3000, Belgium.
Radaelli E; Center for the Biology of Disease, VIB Leuven and Center for Human Genetics, KU Leuven, Herestraat 49, Leuven 3000, Belgium.
Orth MF; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, LMU Munich, Thalkirchner Strasse 36, Munich 80337, Germany.
Verfaillie C; Stem Cell Institute, KU Leuven, Herestraat 49, Leuven 3000, Belgium.
Grünewald TGP; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, LMU Munich, Thalkirchner Strasse 36, Munich 80337, Germany.
Fendt SM; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Herestraat 49, Leuven 3000, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Herestraat 49, Leuven 3000, Belgium.
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Źródło :
Nature communications [Nat Commun] 2017 May 11; Vol. 8, pp. 15267. Date of Electronic Publication: 2017 May 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Lung Neoplasms/*metabolism
Lung Neoplasms/*secondary
Proline/*metabolism
Adenosine Triphosphate ; Aldehyde Dehydrogenase/metabolism ; Animals ; Cell Culture Techniques ; Cell Line, Transformed ; Cell Line, Tumor ; Cell Proliferation ; Humans ; Lung Neoplasms/pathology ; Mice, Inbred C57BL ; Proline Oxidase/metabolism ; Pyrroline Carboxylate Reductases ; Spheroids, Cellular/metabolism ; Spheroids, Cellular/pathology
Czasopismo naukowe

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