Autor: "Orth MF" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Integrative gene network and functional analyses identify a prognostically relevant key regulator of metastasis in Ewing sarcoma.
Autorzy:: Cidre-Aranaz F; Hopp-Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research (B410), German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69210, Heidelberg, Germany.
Li J; Hopp-Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research (B410), German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69210, Heidelberg, Germany.
Hölting TLB; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Orth MF; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Imle R; Hopp-Children's Cancer Center (KiTZ), Heidelberg, Germany.; Soft-Tissue Sarcoma Junior Research Group, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.; Division of Pediatric Surgery, Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany.
Kutschmann S; Hopp-Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research (B410), German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69210, Heidelberg, Germany.
Ammirati G; Regenerative Medicine Technologies Laboratory, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland.
Ceranski K; Hopp-Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research (B410), German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69210, Heidelberg, Germany.
Carreño-Gonzalez MJ; Hopp-Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research (B410), German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69210, Heidelberg, Germany.
Kasan M; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Marchetto A; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Funk CM; Hopp-Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research (B410), German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69210, Heidelberg, Germany.
Bestvater F; Light Microscopy Facility (W210), German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.
Bersini S; Regenerative Medicine Technologies Laboratory, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland.
Arrigoni C; Regenerative Medicine Technologies Laboratory, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland.
Moretti M; Regenerative Medicine Technologies Laboratory, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland.; Biomedical Sciences Faculty, Università della Svizzera Italiana (USI), Lugano, Switzerland.
Thiel U; Technical University of Munich, School of Medicine, Department of Pediatrics and Children's Cancer Research Center, Munich, Germany.
Baumhoer D; Bone Tumor Reference Center, Institute of Pathology of the University Hospital of Basel, Basel, Switzerland.
Sahm F; Hopp-Children's Cancer Center (KiTZ), Heidelberg, Germany.; Clinical Cooperation Unit (CCU) Neuropathology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.
Pfister SM; Hopp-Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Pediatric Neuro-Oncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.
Hartmann W; Division of Translational Pathology, Gerhard-Domagk-Institute for Pathology, University Hospital Münster, Münster, Germany.
Dirksen U; Pediatrics III, AYA Unit, West German Cancer Centre, University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK), partner site Essen, Essen, Germany.
Romero-Pérez L; Hopp-Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research (B410), German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69210, Heidelberg, Germany.
Banito A; Hopp-Children's Cancer Center (KiTZ), Heidelberg, Germany.; Soft-Tissue Sarcoma Junior Research Group, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.
Ohmura S; Hopp-Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research (B410), German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69210, Heidelberg, Germany.
Musa J; Hopp-Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research (B410), German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69210, Heidelberg, Germany.; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.
Kirchner T; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Knott MML; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Grünewald TGP; Hopp-Children's Cancer Center (KiTZ), Heidelberg, Germany. .; Division of Translational Pediatric Sarcoma Research (B410), German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69210, Heidelberg, Germany. .; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany. .; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany. .; Pokaż więcej
Źródło:: Molecular cancer [Mol Cancer] 2022 Jan 03; Vol. 21 (1), pp. 1. Date of Electronic Publication: 2022 Jan 03.
Typ publikacji:: Letter; Research Support, Non-U.S. Gov't
MeSH Terms:: Biomarkers, Tumor*
Gene Expression Regulation, Neoplastic*
Gene Regulatory Networks*
Bone Neoplasms/*genetics
Bone Neoplasms/*mortality
Sarcoma, Ewing/*genetics
Sarcoma, Ewing/*mortality
Animals ; Disease Models, Animal ; Gene Expression Profiling ; Heterografts ; Humans ; Mice ; Neoplasm Staging ; Prognosis ; Sarcoma, Ewing/pathology

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Tytuł:: Translational evidence for RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma.
Autorzy:: Ohmura S; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research (B410), German Cancer Research Center (DKFZ) & Hopp-Children's Cancer Center (KiTZ), Im Neuenheimer Feld 280, 69210, Heidelberg, Germany.; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Marchetto A; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Orth MF; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Li J; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research (B410), German Cancer Research Center (DKFZ) & Hopp-Children's Cancer Center (KiTZ), Im Neuenheimer Feld 280, 69210, Heidelberg, Germany.
Jabar S; Pediatrics III, West German Cancer Centre, University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK), partner site Essen, Essen, Germany.
Ranft A; Pediatrics III, West German Cancer Centre, University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK), partner site Essen, Essen, Germany.
Vinca E; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research (B410), German Cancer Research Center (DKFZ) & Hopp-Children's Cancer Center (KiTZ), Im Neuenheimer Feld 280, 69210, Heidelberg, Germany.
Ceranski K; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research (B410), German Cancer Research Center (DKFZ) & Hopp-Children's Cancer Center (KiTZ), Im Neuenheimer Feld 280, 69210, Heidelberg, Germany.
Carreño-Gonzalez MJ; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research (B410), German Cancer Research Center (DKFZ) & Hopp-Children's Cancer Center (KiTZ), Im Neuenheimer Feld 280, 69210, Heidelberg, Germany.
Romero-Pérez L; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research (B410), German Cancer Research Center (DKFZ) & Hopp-Children's Cancer Center (KiTZ), Im Neuenheimer Feld 280, 69210, Heidelberg, Germany.; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Wehweck FS; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Musa J; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research (B410), German Cancer Research Center (DKFZ) & Hopp-Children's Cancer Center (KiTZ), Im Neuenheimer Feld 280, 69210, Heidelberg, Germany.; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.
Bestvater F; Light Microscopy Facility, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.
Knott MML; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Hölting TLB; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Hartmann W; Division of Translational Pathology, Gerhard-Domagk-Institute for Pathology, University Hospital Münster, Münster, Germany.
Dirksen U; Pediatrics III, West German Cancer Centre, University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK), partner site Essen, Essen, Germany.
Kirchner T; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; German Cancer Consortium (DKTK), partner site Munich, Munich, Germany.
Cidre-Aranaz F; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research (B410), German Cancer Research Center (DKFZ) & Hopp-Children's Cancer Center (KiTZ), Im Neuenheimer Feld 280, 69210, Heidelberg, Germany.; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Grünewald TGP; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany. .; Division of Translational Pediatric Sarcoma Research (B410), German Cancer Research Center (DKFZ) & Hopp-Children's Cancer Center (KiTZ), Im Neuenheimer Feld 280, 69210, Heidelberg, Germany. .; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany. .; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany. .; Pokaż więcej
Źródło:: Molecular cancer [Mol Cancer] 2021 Jul 27; Vol. 20 (1), pp. 97. Date of Electronic Publication: 2021 Jul 27.
Typ publikacji:: Letter; Research Support, Non-U.S. Gov't
MeSH Terms:: Biomarkers, Tumor*
Bone Neoplasms/*etiology
Ribonucleoside Diphosphate Reductase/*genetics
Sarcoma, Ewing/*etiology
Animals ; Bone Neoplasms/diagnosis ; Bone Neoplasms/therapy ; Disease Management ; Disease Models, Animal ; Disease Susceptibility ; Gene Expression Regulation, Neoplastic ; Humans ; Mice ; Molecular Targeted Therapy ; Prognosis ; Pyridines/pharmacology ; Ribonucleoside Diphosphate Reductase/metabolism ; Sarcoma, Ewing/diagnosis ; Sarcoma, Ewing/mortality ; Sarcoma, Ewing/therapy ; Thiosemicarbazones/pharmacology ; Xenograft Model Antitumor Assays

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