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Tytuł :
Role of the Death Receptor and Endoplasmic Reticulum Stress Signaling Pathways in Polyphyllin I-Regulated Apoptosis of Human Hepatocellular Carcinoma HepG2 Cells.
Autorzy :
Luo Q; Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.; Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Yang D; Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Qi Q; Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Huang C; Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.; Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Chen B; Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Liu W; Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.; Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Shi L; Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Xia Y; Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Tang L; Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.; Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Fang J; Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.; Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Ou Y; Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.; Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Geng Y; Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.; Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Chen Z; Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.; Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
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Źródło :
BioMed research international [Biomed Res Int] 2018 Dec 25; Vol. 2018, pp. 5241941. Date of Electronic Publication: 2018 Dec 25 (Print Publication: 2018).
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Carcinoma, Hepatocellular/*metabolism
Diosgenin/*analogs & derivatives
Endoplasmic Reticulum Stress/*physiology
Liver Neoplasms/*metabolism
Receptors, Death Domain/*metabolism
Signal Transduction/*physiology
Caspase 12/metabolism ; Caspase 8/metabolism ; Cell Line, Tumor ; Cell Survival/drug effects ; Cell Survival/physiology ; Diosgenin/pharmacology ; Endoplasmic Reticulum Stress/drug effects ; Hep G2 Cells ; Humans ; Necrosis/metabolism ; Signal Transduction/drug effects ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
Effect and mechanisms of celastrol on the apoptosis of HOS osteosarcoma cells.
Autorzy :
Chen Y; Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Yuzhong, Chongqing 400016, P.R. China.
Ou Y; Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Yuzhong, Chongqing 400016, P.R. China.
Tao Y; Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Yuzhong, Chongqing 400016, P.R. China.
Liu H; Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Yuzhong, Chongqing 400016, P.R. China.
Yin H; Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Yuzhong, Chongqing 400016, P.R. China.
Zhong S; Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Yuzhong, Chongqing 400016, P.R. China.
Yu H; Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Yuzhong, Chongqing 400016, P.R. China.
Zhao Z; Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Yuzhong, Chongqing 400016, P.R. China.
He B; Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Yuzhong, Chongqing 400016, P.R. China.
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Źródło :
Oncology reports [Oncol Rep] 2018 Oct; Vol. 40 (4), pp. 2260-2268. Date of Electronic Publication: 2018 Aug 01.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Bone Neoplasms/*pathology
Endoplasmic Reticulum Stress/*drug effects
Gene Expression Regulation, Neoplastic/*drug effects
Mitochondria/*pathology
Osteosarcoma/*pathology
Triterpenes/*pharmacology
Apoptosis Regulatory Proteins/metabolism ; Autophagy ; Biomarkers, Tumor/metabolism ; Bone Neoplasms/drug therapy ; Bone Neoplasms/metabolism ; Cell Proliferation/drug effects ; Humans ; Mitochondria/drug effects ; Mitochondria/metabolism ; Osteosarcoma/drug therapy ; Osteosarcoma/metabolism ; Reactive Oxygen Species/metabolism ; Signal Transduction ; Tumor Cells, Cultured ; eIF-2 Kinase/metabolism
Czasopismo naukowe
Tytuł :
miR-34a/Bcl-2 signaling pathway contributes to age-related hearing loss by modulating hair cell apoptosis.
Autorzy :
Huang Q; Department of Otolaryngology-HNS, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen university, 107 Yanjiang West Rd, Guangzhou 510120, China; Institute of Hearing and Speech-Language Science, Sun Yat-sen University, China.
Zheng Y; Department of Otolaryngology-HNS, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen university, 107 Yanjiang West Rd, Guangzhou 510120, China; Institute of Hearing and Speech-Language Science, Sun Yat-sen University, China. Electronic address: .
Ou Y; Department of Otolaryngology-HNS, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen university, 107 Yanjiang West Rd, Guangzhou 510120, China; Institute of Hearing and Speech-Language Science, Sun Yat-sen University, China.
Xiong H; Department of Otolaryngology-HNS, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen university, 107 Yanjiang West Rd, Guangzhou 510120, China; Institute of Hearing and Speech-Language Science, Sun Yat-sen University, China.
Yang H; Department of Otolaryngology-HNS, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen university, 107 Yanjiang West Rd, Guangzhou 510120, China; Institute of Hearing and Speech-Language Science, Sun Yat-sen University, China.
Zhang Z; Department of Otolaryngology-HNS, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen university, 107 Yanjiang West Rd, Guangzhou 510120, China; Institute of Hearing and Speech-Language Science, Sun Yat-sen University, China.
Chen S; Department of Otolaryngology-HNS, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen university, 107 Yanjiang West Rd, Guangzhou 510120, China; Institute of Hearing and Speech-Language Science, Sun Yat-sen University, China.
Ye Y; Department of Otolaryngology-HNS, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen university, 107 Yanjiang West Rd, Guangzhou 510120, China; Institute of Hearing and Speech-Language Science, Sun Yat-sen University, China.
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Źródło :
Neuroscience letters [Neurosci Lett] 2017 Nov 20; Vol. 661, pp. 51-56. Date of Electronic Publication: 2017 Jul 26.
Typ publikacji :
Journal Article; Retracted Publication
MeSH Terms :
Apoptosis/*genetics
Hair Cells, Auditory/*metabolism
Hearing Loss/*genetics
MicroRNAs/*genetics
Age Factors ; Animals ; Apoptosis/drug effects ; Cell Line, Tumor ; Genes, bcl-2/genetics ; Hearing Loss/metabolism ; Male ; Mice, Inbred C57BL ; MicroRNAs/metabolism ; Signal Transduction/genetics ; Up-Regulation
Czasopismo naukowe
Tytuł :
The miR-34a/Bcl-2 Pathway Contributes to Auditory Cortex Neuron Apoptosis in Age-Related Hearing Loss.
Autorzy :
Huang Q; Department of Otolaryngology-HNS, Sun Yat-Sen Memorial Hospital and Institute of Hearing and Speech-Language Science, Sun Yat-Sen University, Guangzhou, China.
Ou Y
Xiong H
Yang H
Zhang Z
Chen S
Ye Y
Zheng Y
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Źródło :
Audiology & neuro-otology [Audiol Neurootol] 2017; Vol. 22 (2), pp. 96-103. Date of Electronic Publication: 2017 Aug 18.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*genetics
Auditory Cortex/*metabolism
MicroRNAs/*genetics
Neurons/*metabolism
Presbycusis/*genetics
Proto-Oncogene Proteins c-bcl-2/*genetics
Animals ; Auditory Cortex/cytology ; Auditory Cortex/physiopathology ; Evoked Potentials, Auditory, Brain Stem/genetics ; Evoked Potentials, Auditory, Brain Stem/physiology ; Hearing ; Hearing Loss ; Mice ; Mice, Inbred C57BL ; MicroRNAs/metabolism ; Presbycusis/metabolism ; Presbycusis/physiopathology ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Role of the ERK1/2 pathway in osmolarity effects on nucleus pulposus cell apoptosis in a disc perfusion culture.
Autorzy :
Li P; Department of Orthopedic Surgery, Southwest Hospital, Third Military Medical University, GaoTanYan 29, Chongqing 400038, China.
Gan Y; Department of Orthopedic Surgery, Southwest Hospital, Third Military Medical University, GaoTanYan 29, Chongqing 400038, China.
Wang H; Department of Orthopedic Surgery, Chongqing Three Gorges Central Hospital, Chongqing 404000, China.
Xu Y; Department of Orthopedic Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Li S; Department of Orthopedic Surgery, No. 181 Hospital of PLA, Guilin, Guangxi 541002, China.
Song L; Department of Orthopedic Surgery, Southwest Hospital, Third Military Medical University, GaoTanYan 29, Chongqing 400038, China.
Zhang C; Department of Orthopedic Surgery, Southwest Hospital, Third Military Medical University, GaoTanYan 29, Chongqing 400038, China.
Ou Y; Department of Orthopedic Surgery, Southwest Hospital, Third Military Medical University, GaoTanYan 29, Chongqing 400038, China.
Wang L; Department of Orthopedic Surgery, Southwest Hospital, Third Military Medical University, GaoTanYan 29, Chongqing 400038, China.
Zhou Q; Department of Orthopedic Surgery, Southwest Hospital, Third Military Medical University, GaoTanYan 29, Chongqing 400038, China.
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Źródło :
Journal of orthopaedic research : official publication of the Orthopaedic Research Society [J Orthop Res] 2017 Jan; Vol. 35 (1), pp. 86-92. Date of Electronic Publication: 2016 May 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
MAP Kinase Signaling System*
Nucleus Pulposus/*physiology
Animals ; Caspase 3/metabolism ; In Situ Nick-End Labeling ; Male ; Osmolar Concentration ; Protein Biosynthesis ; Swine ; Tissue Culture Techniques
Czasopismo naukowe
Tytuł :
The Relationship between the Bcl-2/Bax Proteins and the Mitochondria-Mediated Apoptosis Pathway in the Differentiation of Adipose-Derived Stromal Cells into Neurons.
Autorzy :
Wang Q; Department of Neurology, Affiliated Kailuan General Hospital of North China, University of Science and Technology, Tangshan, 063000, Hebei Province, China.
Zhang L; Department of Neurology, Affiliated Kailuan General Hospital of North China, University of Science and Technology, Tangshan, 063000, Hebei Province, China.
Yuan X; Department of Neurology, Affiliated Kailuan General Hospital of North China, University of Science and Technology, Tangshan, 063000, Hebei Province, China.
Ou Y; Department of Neurology, Affiliated Kailuan General Hospital of North China, University of Science and Technology, Tangshan, 063000, Hebei Province, China.
Zhu X; Department of Neurology, Affiliated Kailuan General Hospital of North China, University of Science and Technology, Tangshan, 063000, Hebei Province, China.
Cheng Z; Department of Neurology, Affiliated Kailuan General Hospital of North China, University of Science and Technology, Tangshan, 063000, Hebei Province, China.
Zhang P; Key Laboratory of Neurological and Biological Function of Hebei Province, Tangshan, 063000, Hebei Province, China.
Wu X; Key Laboratory of Neurology of Tangshan, Tangshan, 063000, Hebei Province, Tangshan, 063000, Hebei Province, China.
Meng Y; Department of Neurology, Affiliated Kailuan General Hospital of North China, University of Science and Technology, Tangshan, 063000, Hebei Province, China.
Zhang L; Department of Neurology, Affiliated Kailuan General Hospital of North China, University of Science and Technology, Tangshan, 063000, Hebei Province, China.
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Źródło :
PloS one [PLoS One] 2016 Oct 05; Vol. 11 (10), pp. e0163327. Date of Electronic Publication: 2016 Oct 05 (Print Publication: 2016).
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
Mitochondria/*metabolism
Neurons/*cytology
Proto-Oncogene Proteins c-bcl-2/*metabolism
Stromal Cells/*cytology
bcl-2-Associated X Protein/*metabolism
Adipose Tissue/cytology ; Caspase 3/metabolism ; Caspase 9/metabolism ; Cell Differentiation ; Cells, Cultured ; Cytochromes c/metabolism ; Humans ; Immunohistochemistry ; Membrane Potential, Mitochondrial ; Microscopy, Confocal ; Microscopy, Electron, Transmission ; Mitochondria/ultrastructure ; Neurons/metabolism ; Stromal Cells/metabolism
Czasopismo naukowe
Tytuł :
Phycocyanin Inhibits Tumorigenic Potential of Pancreatic Cancer Cells: Role of Apoptosis and Autophagy.
Autorzy :
Liao G; School of Life Science &Technology, China Pharmaceutical University, Nanjing, China.
Gao B; School of Life Science &Technology, China Pharmaceutical University, Nanjing, China.
Gao Y; School of Life Science &Technology, China Pharmaceutical University, Nanjing, China.
Yang X; School of Life Science &Technology, China Pharmaceutical University, Nanjing, China.
Cheng X; Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center, Houston, USA.
Ou Y; School of Life Science &Technology, China Pharmaceutical University, Nanjing, China.
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Źródło :
Scientific reports [Sci Rep] 2016 Oct 03; Vol. 6, pp. 34564. Date of Electronic Publication: 2016 Oct 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
Autophagy/*drug effects
Pancreatic Neoplasms/*drug therapy
Phycocyanin/*pharmacology
Signal Transduction/*drug effects
Animals ; G2 Phase Cell Cycle Checkpoints/drug effects ; Hep G2 Cells ; Human Umbilical Vein Endothelial Cells ; Humans ; M Phase Cell Cycle Checkpoints/drug effects ; MCF-7 Cells ; Mice ; Mice, Nude ; Neoplasm Proteins/metabolism ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/pathology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Crocodile blood extract induces the apoptosis of lung cancer cells through PTEN activity.
Autorzy :
Ou Y; School of Life Sciences, The Chinese University of Hong Kong, NT, Hong Kong, SAR, P.R. China.
Ho WS; School of Life Sciences, The Chinese University of Hong Kong, NT, Hong Kong, SAR, P.R. China.
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Źródło :
Oncology reports [Oncol Rep] 2016 Sep; Vol. 36 (3), pp. 1457-66. Date of Electronic Publication: 2016 Jul 05.
Typ publikacji :
Journal Article
MeSH Terms :
Alligators and Crocodiles/*blood
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Biological Factors/*pharmacology
Lung Neoplasms/*drug therapy
PTEN Phosphohydrolase/*genetics
A549 Cells ; Animals ; Caspases/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cytochromes c/metabolism ; Down-Regulation/drug effects ; G1 Phase Cell Cycle Checkpoints/drug effects ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; M Phase Cell Cycle Checkpoints/drug effects ; Membrane Potential, Mitochondrial/drug effects ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects ; Up-Regulation/drug effects
Czasopismo naukowe
Tytuł :
Aloe-emodin-mediated photodynamic therapy induces autophagy and apoptosis in human osteosarcoma cell line MG‑63 through the ROS/JNK signaling pathway.
Autorzy :
Tu P; Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Yuzhong, Chongqing 400016, P.R. China.
Huang Q; Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Yuzhong, Chongqing 400016, P.R. China.
Ou Y; Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Yuzhong, Chongqing 400016, P.R. China.
Du X; Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Yuzhong, Chongqing 400016, P.R. China.
Li K; Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Yuzhong, Chongqing 400016, P.R. China.
Tao Y; Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Yuzhong, Chongqing 400016, P.R. China.
Yin H; Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Yuzhong, Chongqing 400016, P.R. China.
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Źródło :
Oncology reports [Oncol Rep] 2016 Jun; Vol. 35 (6), pp. 3209-15. Date of Electronic Publication: 2016 Mar 24.
Typ publikacji :
Journal Article
MeSH Terms :
Anthraquinones/*pharmacology
Apoptosis/*drug effects
Autophagy/*drug effects
Bone Neoplasms/*drug therapy
Osteosarcoma/*drug therapy
Photosensitizing Agents/*pharmacology
Acetylcysteine/pharmacology ; Anthracenes/pharmacology ; Apoptosis Regulatory Proteins/metabolism ; Bone Neoplasms/pathology ; Cell Line, Tumor ; Cell Survival/drug effects ; Drug Screening Assays, Antitumor ; Humans ; JNK Mitogen-Activated Protein Kinases/metabolism ; MAP Kinase Signaling System ; Osteosarcoma/pathology ; Photochemotherapy ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
Phycocyanin prevents methylglyoxal-induced mitochondrial-dependent apoptosis in INS-1 cells by Nrf2.
Autorzy :
Gao Y; School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China. .
Liu C; School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China. .
Wan G; School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China. .
Wang X; School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China. .
Cheng X; Department of Integrative Biology and Pharmacology, Texas Therapeutics Institute, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, USA. .
Ou Y; School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China. .
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Źródło :
Food & function [Food Funct] 2016 Feb; Vol. 7 (2), pp. 1129-37.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
Mitochondria/*drug effects
NF-E2-Related Factor 2/*metabolism
Phycocyanin/*pharmacology
Pyruvaldehyde/*toxicity
Antioxidants/pharmacology ; Apoptosis Inducing Factor/metabolism ; Cells, Cultured ; Cytochromes c/metabolism ; Heme Oxygenase-1/genetics ; Heme Oxygenase-1/metabolism ; Humans ; Insulin/metabolism ; Insulin Secretion ; Insulin-Secreting Cells/cytology ; Insulin-Secreting Cells/drug effects ; Lactoylglutathione Lyase/genetics ; Lactoylglutathione Lyase/metabolism ; NF-E2-Related Factor 2/genetics ; Oxidative Stress/drug effects ; Reactive Oxygen Species/metabolism ; bcl-2-Associated X Protein/genetics ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe
Tytuł :
Activation of miR-34a/SIRT1/p53 signaling contributes to cochlear hair cell apoptosis: implications for age-related hearing loss.
Autorzy :
Xiong H; Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, China.
Pang J; Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, China.
Yang H; Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, China.
Dai M; Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Liu Y; Guangzhou Occupational Disease Prevention and Treatment Center, Guangzhou, China.
Ou Y; Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, China.
Huang Q; Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, China.
Chen S; Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, China.
Zhang Z; Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, China.
Xu Y; Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, China.
Lai L; Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, China.
Zheng Y; Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, China. Electronic address: .
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Źródło :
Neurobiology of aging [Neurobiol Aging] 2015 Apr; Vol. 36 (4), pp. 1692-1701. Date of Electronic Publication: 2015 Jan 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aging*
Apoptosis/*genetics
Hair Cells, Auditory/*pathology
Hearing Loss, Sensorineural/*pathology
MicroRNAs/*physiology
Signal Transduction/*physiology
Sirtuin 1/*physiology
Tumor Suppressor Protein p53/*physiology
Acetylation ; Animals ; Apoptosis/drug effects ; Cell Line ; Gene Expression ; Hearing Loss, Sensorineural/drug therapy ; Mice, Inbred C57BL ; Resveratrol ; Signal Transduction/drug effects ; Sirtuin 1/metabolism ; Stilbenes/administration & dosage ; Stilbenes/pharmacology ; Tumor Suppressor Protein p53/metabolism
Czasopismo naukowe
Tytuł :
The relationship between mitochondrial fusion/fission and apoptosis in the process of adipose-derived stromal cells differentiation into astrocytes.
Autorzy :
Zhang L; Department of Neurology, Affiliated Kailuan General Hospital of Hebei United University, No. 57, East Xinhua Road, Tangshan 063000, Hebei, China.
Yuan X; Department of Neurology, Affiliated Kailuan General Hospital of Hebei United University, No. 57, East Xinhua Road, Tangshan 063000, Hebei, China. Electronic address: .
Wang S; Department of Neurology, Affiliated Kailuan General Hospital of Hebei United University, No. 57, East Xinhua Road, Tangshan 063000, Hebei, China.
Ou Y; Department of Neurology, Affiliated Kailuan General Hospital of Hebei United University, No. 57, East Xinhua Road, Tangshan 063000, Hebei, China.
Zheng X; Department of Neurology, Affiliated Kailuan General Hospital of Hebei United University, No. 57, East Xinhua Road, Tangshan 063000, Hebei, China.
Wang Q; Department of Neurology, Affiliated Kailuan General Hospital of Hebei United University, No. 57, East Xinhua Road, Tangshan 063000, Hebei, China.
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Źródło :
Neuroscience letters [Neurosci Lett] 2014 Jul 11; Vol. 575, pp. 19-24. Date of Electronic Publication: 2014 May 23.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Differentiation*
Mitochondrial Dynamics*
Adipose Tissue/*cytology
Apoptosis/*physiology
Astrocytes/*cytology
Astrocytes/ultrastructure ; Caspase 3/metabolism ; Cell Survival ; Female ; GTP Phosphohydrolases/metabolism ; Glial Fibrillary Acidic Protein/metabolism ; Humans ; Membrane Proteins/metabolism ; Mitochondrial Proteins/metabolism ; Stromal Cells/cytology ; Stromal Cells/ultrastructure ; Young Adult
Czasopismo naukowe
Tytuł :
Molecular mechanisms of exopolysaccharide from Aphanothece halaphytica (EPSAH) induced apoptosis in HeLa cells.
Autorzy :
Ou Y; School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.
Xu S; School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.
Zhu D; School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.
Yang X; School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.
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Źródło :
PloS one [PLoS One] 2014 Jan 23; Vol. 9 (1), pp. e87223. Date of Electronic Publication: 2014 Jan 23 (Print Publication: 2014).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
Cell Proliferation/*drug effects
Cyanobacteria/*metabolism
Membrane Potential, Mitochondrial/*drug effects
Polysaccharides/*pharmacology
Apoptosis Regulatory Proteins/metabolism ; Blotting, Western ; Caspases/metabolism ; Cells, Cultured ; Cyanobacteria/growth & development ; HeLa Cells ; Humans
Czasopismo naukowe
Tytuł :
Polyphenol extract of Phyllanthus emblica (PEEP) induces inhibition of cell proliferation and triggers apoptosis in cervical cancer cells.
Autorzy :
Zhu X; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji University, No,389 Xincun Road, Shanghai 200065, China. .
Wang J
Ou Y
Han W
Li H
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Źródło :
European journal of medical research [Eur J Med Res] 2013 Nov 19; Vol. 18, pp. 46. Date of Electronic Publication: 2013 Nov 19.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Phyllanthus emblica/*chemistry
Plant Extracts/*pharmacology
Polyphenols/*pharmacology
Uterine Cervical Neoplasms/*drug therapy
Uterine Cervical Neoplasms/*pathology
Caspase 8/metabolism ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor ; Fas Ligand Protein/metabolism ; Female ; G2 Phase Cell Cycle Checkpoints/drug effects ; HeLa Cells ; Humans ; Karyotyping ; Mitosis/drug effects ; Phytotherapy ; Plant Extracts/therapeutic use ; Polyphenols/therapeutic use ; Uterine Cervical Neoplasms/enzymology ; fas Receptor/metabolism
Czasopismo naukowe
Tytuł :
Overexpression of cyclin B1 antagonizes chemotherapeutic-induced apoptosis through PTEN/Akt pathway in human esophageal squamous cell carcinoma cells.
Autorzy :
Ou Y; State Key Laboratory of Molecular Oncology, Cancer Institute and Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Ma L
Ma L
Huang Z
Zhou W
Zhao C
Zhang B
Song Y
Yu C
Zhan Q
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Źródło :
Cancer biology & therapy [Cancer Biol Ther] 2013 Jan; Vol. 14 (1), pp. 45-55. Date of Electronic Publication: 2012 Oct 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
Carcinoma, Squamous Cell/*drug therapy
Cyclin B1/*metabolism
Esophageal Neoplasms/*drug therapy
PTEN Phosphohydrolase/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Antineoplastic Agents/pharmacology ; Caspases/metabolism ; Cell Line, Tumor/drug effects ; Cell Survival/drug effects ; Chromones/pharmacology ; Cisplatin/pharmacology ; Cyclin B1/genetics ; Drug Resistance, Neoplasm ; Gene Knockdown Techniques ; Humans ; Morpholines/pharmacology ; Paclitaxel/pharmacology ; Phosphoinositide-3 Kinase Inhibitors ; Proto-Oncogene Proteins c-akt/antagonists & inhibitors ; Proto-Oncogene Proteins c-bcl-2/metabolism ; RNA, Small Interfering/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł :
Phycocyanin may suppress D-galactose-induced human lens epithelial cell apoptosis through mitochondrial and unfolded protein response pathways.
Autorzy :
Ou Y; School of Life Science and Technology, China Pharmaceutical University, Nanjing, China. />Yuan Z
Li K
Yang X
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Źródło :
Toxicology letters [Toxicol Lett] 2012 Nov 23; Vol. 215 (1), pp. 25-30. Date of Electronic Publication: 2012 Oct 02.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Epithelial Cells/*drug effects
Galactose/*antagonists & inhibitors
Galactose/*toxicity
Lens, Crystalline/*cytology
Mitochondria/*drug effects
Phycocyanin/*pharmacology
Unfolded Protein Response/*drug effects
Apoptosis Regulatory Proteins/metabolism ; Blotting, Western ; Caspase 3/metabolism ; Cell Survival/drug effects ; Cells, Cultured ; DNA Fragmentation/drug effects ; Enzyme Activation/drug effects ; Epithelial Cells/ultrastructure ; Humans ; Lens, Crystalline/drug effects ; Microscopy, Fluorescence ; Tetrazolium Salts ; Thiazoles
Czasopismo naukowe
Tytuł :
Recombination adenovirus-mediated human lactoferrin cDNA inhibits the growth of human MCF-7 breast cancer cells.
Autorzy :
Wang J; Department of Biological Engineering, College of Environment and Chemical Engineering, Yanshan University, Qinhuangdao, Japan.
Li Q
Ou Y
Li K
Han Z
Wang P
Zhou S
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Źródło :
The Journal of pharmacy and pharmacology [J Pharm Pharmacol] 2012 Mar; Vol. 64 (3), pp. 457-63. Date of Electronic Publication: 2011 Nov 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Therapy*
Adenoviridae/*genetics
Apoptosis/*drug effects
Lactoferrin/*genetics
Apoptosis Regulatory Proteins/genetics ; Bcl-2-Like Protein 11 ; Blotting, Western ; Breast Neoplasms/pathology ; Caspase 3/genetics ; Cell Cycle/genetics ; DNA, Complementary/genetics ; Female ; Flow Cytometry ; Gene Expression Regulation, Neoplastic/physiology ; Genetic Vectors ; Green Fluorescent Proteins/genetics ; Humans ; Membrane Proteins/genetics ; Polymerase Chain Reaction ; Proto-Oncogene Proteins/genetics ; Tumor Cells, Cultured ; bcl-2-Associated X Protein/genetics
Czasopismo naukowe
Tytuł :
Mechanism of tetramethylpyrazine analogue CXC195 inhibition of hydrogen peroxide-induced apoptosis in human endothelial cells.
Autorzy :
Ou Y; Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, PR China.
Dong X
Liu XY
Cheng XC
Cheng YN
Yu LG
Guo XL
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Źródło :
Biological & pharmaceutical bulletin [Biol Pharm Bull] 2010; Vol. 33 (3), pp. 432-8.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antioxidants/*pharmacology
Apoptosis/*drug effects
Calcium/*metabolism
Drugs, Chinese Herbal/*pharmacology
Endothelial Cells/*drug effects
Ligusticum/*chemistry
Membrane Potential, Mitochondrial/*drug effects
Piperazines/*pharmacology
Pyrazines/*pharmacology
Antioxidants/chemical synthesis ; Caspase 3/metabolism ; Cell Line ; Down-Regulation ; Endothelial Cells/metabolism ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Flow Cytometry ; Humans ; Hydrogen Peroxide/pharmacology ; Oxidative Stress/drug effects ; Phosphorylation ; Phytotherapy ; Piperazines/chemical synthesis ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Pyrazines/chemical synthesis ; Tumor Suppressor Protein p53/metabolism ; Umbilical Veins
Czasopismo naukowe
Tytuł :
Intracellular GSH and ROS levels may be related to galactose-mediated human lens epithelial cell apoptosis: role of recombinant hirudin variant III.
Autorzy :
Ou Y; School of Life Science and Technology, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China. />Geng P
Liao GY
Zhou Z
Wu WT
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2009 May 15; Vol. 179 (2-3), pp. 103-9. Date of Electronic Publication: 2008 Nov 05.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Epithelial Cells/*drug effects
Galactose/*toxicity
Glutathione/*metabolism
Hirudins/*pharmacology
Lens, Crystalline/*drug effects
Reactive Oxygen Species/*metabolism
Annexin A5/chemistry ; Cell Survival/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Epithelial Cells/metabolism ; Fluorescein/chemistry ; Glutathione/analysis ; Hirudins/classification ; Humans ; Lens, Crystalline/cytology ; Lens, Crystalline/metabolism ; Microscopy, Fluorescence ; Reactive Oxygen Species/analysis ; Recombinant Proteins/pharmacology ; Staining and Labeling
Czasopismo naukowe

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