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Tytuł :
Metabolomic approach to characterize the metabolic phenotypes and varied response to ouabain of diffuse large B-cell lymphoma cells.
Autorzy :
Zheng M; Phase I Clinical Trials Unit, Nanjing Drum Tower Hospital, The affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Zhou X; Phase I Clinical Trials Unit, Nanjing Drum Tower Hospital, The affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Wang Q; Phase I Clinical Trials Unit, Nanjing Drum Tower Hospital, The affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Chen X; Department of General Surgery, Nanjing Drum Tower Hospital, The affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Cao B; Phase I Clinical Trials Unit, Nanjing Drum Tower Hospital, The affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Li J; Phase I Clinical Trials Unit, Nanjing Drum Tower Hospital, The affiliated Hospital of Nanjing University Medical School, Nanjing, China.
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Źródło :
Leukemia & lymphoma [Leuk Lymphoma] 2021 Jul; Vol. 62 (7), pp. 1597-1608. Date of Electronic Publication: 2021 Feb 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Lymphoma, Large B-Cell, Diffuse*/drug therapy
Lymphoma, Large B-Cell, Diffuse*/genetics
Ouabain*/pharmacology
Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Germinal Center ; Humans ; Phenotype ; Prognosis
Czasopismo naukowe
Tytuł :
Na -ATPase Revisited: On Its Mechanism of Action, Role in Cancer, and Activity Modulation.
Autorzy :
Bejček J; Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Technická 3, 166 28 Prague 6, Czech Republic.
Spiwok V; Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Technická 3, 166 28 Prague 6, Czech Republic.
Kmoníčková E; Department of Pharmacology, Second Faculty of Medicine, Charles University, Plzeňská 311, 150 00 Prague, Czech Republic.
Rimpelová S; Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Technická 3, 166 28 Prague 6, Czech Republic.; Department of Pharmacology, Second Faculty of Medicine, Charles University, Plzeňská 311, 150 00 Prague, Czech Republic.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Mar 28; Vol. 26 (7). Date of Electronic Publication: 2021 Mar 28.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Digitoxin/*therapeutic use
Digoxin/*therapeutic use
Enzyme Inhibitors/*therapeutic use
Ouabain/*therapeutic use
Sodium-Potassium-Exchanging ATPase/*antagonists & inhibitors
Animals ; Antineoplastic Agents/chemistry ; Brain Neoplasms/drug therapy ; Brain Neoplasms/enzymology ; Brain Neoplasms/pathology ; Clinical Trials as Topic ; Digitoxin/chemistry ; Digoxin/chemistry ; Drug Repositioning ; Enzyme Inhibitors/chemistry ; Glioblastoma/drug therapy ; Glioblastoma/enzymology ; Glioblastoma/pathology ; Humans ; Isoenzymes/antagonists & inhibitors ; Isoenzymes/chemistry ; Isoenzymes/metabolism ; Lung Neoplasms/drug therapy ; Lung Neoplasms/enzymology ; Lung Neoplasms/pathology ; Models, Molecular ; Ouabain/chemistry ; Protein Binding ; Protein Conformation ; Sodium-Potassium-Exchanging ATPase/chemistry ; Sodium-Potassium-Exchanging ATPase/metabolism
Czasopismo naukowe
Tytuł :
Ouabain induces memory impairment and alter the BDNF signaling pathway in an animal model of bipolar disorder: Cognitive and neurochemical alterations in BD model.
Autorzy :
Valvassori SS; Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil. Electronic address: .
Dal-Pont GC; Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil.
Varela RB; Queensland Brain Institute, The Universty of Queensland, St Lucia, QLD 4072, Australia.
Resende WR; Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil.
Gava FF; Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil.
Mina FG; Experimental Neurology Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil.
Budni J; Experimental Neurology Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil.
Quevedo J; Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil; Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, United States; Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, United States; Neuroscience Graduate Program, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, Texas, United States.
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Źródło :
Journal of affective disorders [J Affect Disord] 2021 Mar 01; Vol. 282, pp. 1195-1202. Date of Electronic Publication: 2020 Dec 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bipolar Disorder*/chemically induced
Ouabain*/toxicity
Animals ; Brain-Derived Neurotrophic Factor/metabolism ; Cognition ; Disease Models, Animal ; Hippocampus/metabolism ; Humans ; Rats ; Rats, Wistar ; Signal Transduction
Czasopismo naukowe
Tytuł :
Beneficent and Maleficent Effects of Cations on Bufadienolide Binding to Na -ATPase.
Autorzy :
Ladefoged LK; Department of Biomedicine, Aarhus University, Høegh-Guldbergsgade 10, 8000 Aarhus C, Denmark.; Department of Chemistry, Aarhus University, Langelandsgade 140, 8000 Aarhus C, Denmark.
Schiøtt B; Department of Chemistry, Aarhus University, Langelandsgade 140, 8000 Aarhus C, Denmark.
Fedosova NU; Department of Biomedicine, Aarhus University, Høegh-Guldbergsgade 10, 8000 Aarhus C, Denmark.
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Źródło :
Journal of chemical information and modeling [J Chem Inf Model] 2021 Feb 22; Vol. 61 (2), pp. 976-986. Date of Electronic Publication: 2021 Jan 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bufanolides*
Ouabain*
Cations ; Sodium-Potassium-Exchanging ATPase/metabolism
Czasopismo naukowe
Tytuł :
Ouabain regulates kidney metabolic profiling in rat offspring of intrauterine growth restriction induced by low-protein diet.
Autorzy :
Wang Q; Phase I Clinical Trials Unit, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China.
Yue J; Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China.
Zhou X; Phase I Clinical Trials Unit, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China.
Zheng M; Phase I Clinical Trials Unit, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China.
Cao B; Phase I Clinical Trials Unit, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China. Electronic address: .
Li J; Phase I Clinical Trials Unit, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Oct 15; Vol. 259, pp. 118281. Date of Electronic Publication: 2020 Aug 12.
Typ publikacji :
Journal Article
MeSH Terms :
Fetal Growth Retardation/*metabolism
Kidney/*metabolism
Ouabain/*pharmacology
Animals ; Arginine/metabolism ; Diet, Protein-Restricted ; Female ; Fetal Development/drug effects ; Fetal Growth Retardation/physiopathology ; Fetal Weight/drug effects ; Hypertension/physiopathology ; Kidney/drug effects ; Kidney Diseases/metabolism ; Kidney Glomerulus/metabolism ; Male ; Metabolomics ; Ouabain/metabolism ; Pregnancy ; Prenatal Exposure Delayed Effects/metabolism ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Circulating Ouabain Modulates Expression of Claudins in Rat Intestine and Cerebral Blood Vessels.
Autorzy :
Markov AG; Department of General Physiology, St. Petersburg State University, 199034 St. Petersburg, Russia.
Fedorova AA; Department of General Physiology, St. Petersburg State University, 199034 St. Petersburg, Russia.
Kravtsova VV; Department of General Physiology, St. Petersburg State University, 199034 St. Petersburg, Russia.
Bikmurzina AE; Department of General Physiology, St. Petersburg State University, 199034 St. Petersburg, Russia.
Okorokova LS; Department of General Physiology, St. Petersburg State University, 199034 St. Petersburg, Russia.
Matchkov VV; Department of Biomedicine, University of Aarhus, C 8000 Aarhus, Denmark.
Cornelius V; Institute of Veterinary Physiology, Freie Universität Berlin, 14163 Berlin, Germany.
Amasheh S; Institute of Veterinary Physiology, Freie Universität Berlin, 14163 Berlin, Germany.
Krivoi II; Department of General Physiology, St. Petersburg State University, 199034 St. Petersburg, Russia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Jul 17; Vol. 21 (14). Date of Electronic Publication: 2020 Jul 17.
Typ publikacji :
Journal Article
MeSH Terms :
Brain/*blood supply
Claudins/*analysis
Intestinal Mucosa/*drug effects
Ouabain/*pharmacology
Animals ; Brain/drug effects ; Capillary Permeability/drug effects ; Cell Line ; Claudins/metabolism ; Intestinal Mucosa/metabolism ; Intestines/drug effects ; Male ; Ouabain/administration & dosage ; Ouabain/blood ; Permeability/drug effects ; Rats ; Rats, Wistar ; Swine ; Tight Junctions/drug effects ; Tight Junctions/metabolism
Czasopismo naukowe
Tytuł :
Ouabain Suppresses Cell Migration and Invasion in Human Gastric Cancer AGS Cells Through the Inhibition of MMP Signaling Pathways.
Autorzy :
Chen HY; Department of Pharmacy, School of Pharmacy, China Medical University, Taichung, Taiwan, R.O.C.; Department of Pharmacy, China Medical University Beigang Hospital, Yunlin, Taiwan, R.O.C.
Yang MD; Department of Surgery, China Medical University Hospital, Taichung, Taiwan, R.O.C.
Chou YC; Department of Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.; Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, R.O.C.
Ma YS; School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung, Taiwan, R.O.C.; Department of Chinese Medicine, E-Da Hospital, Kaohsiung, Taiwan, R.O.C.
Peng SF; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan, R.O.C.
Liao CL; College of Chinese Medicine, School of Post-Baccalaureate Chinese Medicine, China Medical University, Taichung, Taiwan, R.O.C.
Chen PY; Department of Biological Science and Technology, College of Life Science, China Medical University, Taichung, Taiwan, R.O.C.
Hsia TC; Department of Respiratory Therapy, China Medical University, Taichung, Taiwan, R.O.C.; Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan, R.O.C.
Lien JC; School of Pharmacy, China Medical University, Taichung, Taiwan, R.O.C.; .
Chen CH; Division of Gastroenterology, Department of Internal Medicine, Chang Bing Show-Chwan Memorial Hospital, Changhua, Taiwan, R.O.C. .
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Źródło :
Anticancer research [Anticancer Res] 2021 Sep; Vol. 41 (9), pp. 4365-4375.
Typ publikacji :
Journal Article
MeSH Terms :
MAP Kinase Signaling System/*drug effects
Matrix Metalloproteinase 2/*metabolism
Ouabain/*pharmacology
Stomach Neoplasms/*metabolism
Antigens, CD/metabolism ; Cadherins/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Neoplasm Invasiveness ; Signal Transduction/drug effects ; Stomach Neoplasms/drug therapy ; Tissue Inhibitor of Metalloproteinase-1/metabolism
Czasopismo naukowe
Tytuł :
Ouabain Induces DNA Damage in Human Osteosarcoma U-2 OS Cells and Alters the Expression of DNA Damage and DNA Repair-associated Proteins.
Autorzy :
Yang JL; Department of Nursing, Saint Mary's Junior College of Medicine, Nursing and Management, Yilan, Taiwan, R.O.C.
Yang MD; Department of Surgery, China Medical University Hospital, Taichung, Taiwan, R.O.C.
Chen JC; Department of Medicinal Botany and Health Applications, Da-Yeh University, Changhua, Taiwan, R.O.C.
Lu KW; College of Chinese Medicine, School of Post-Baccalaureate Chinese Medicine, China Medical University, Taichung, Taiwan, R.O.C.
Huang YP; Department of Physiology, School of Medicine, China Medical University, Taichung, Taiwan, R.O.C.
Peng SF; Department of Biological Science and Technology, China Medical University, Taichung, Taiwan, R.O.C.; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
Chueh FS; Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan, R.O.C.
Liu KC; Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan, R.O.C.
Lin TS; Department of Nursing, Saint Mary's Junior College of Medicine, Nursing and Management, Yilan, Taiwan, R.O.C.; Department of Pharmacy, Saint Mary's Hospital Luodong, Yilan, Taiwan, R.O.C.
Chen PY; Department of Biological Science and Technology, China Medical University, Taichung, Taiwan, R.O.C.; .
Chen WJ; Department of Orthopedics, Chang Bing Show-Chwan Memorial Hospital, Changhua, Taiwan, R.O.C.; .; Department of Orthopedics, Show-Chwan Memorial Hospital, Changhua, Taiwan, R.O.C.
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Źródło :
In vivo (Athens, Greece) [In Vivo] 2021 Sep-Oct; Vol. 35 (5), pp. 2687-2696.
Typ publikacji :
Journal Article
MeSH Terms :
Bone Neoplasms*/drug therapy
Bone Neoplasms*/genetics
Osteosarcoma*/drug therapy
Osteosarcoma*/genetics
Apoptosis ; Cell Line, Tumor ; DNA Damage ; DNA Repair ; Humans ; Ouabain/pharmacology
Czasopismo naukowe
Tytuł :
In vitro antitumoral effects of the steroid ouabain on human thyroid papillary carcinoma cell lines.
Autorzy :
Teixeira MP; Laboratório de Imunorregulação, Departamento de Imunobiologia, Instituto de Biologia, Universidade Federal Fluminense, Niterói, Brazil.; Programa de Pós-Graduação em Patologia, Universidade Federal Fluminense, Niterói, Brazil.; Laboratório de Endocrinologia Experimental-LEEx, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.; Programa de Pós-Graduação em Endocrinologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Passos EF; Laboratório de Fisiologia Endócrina Doris Rosenthal, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Haddad NF; Programa de Pós-Graduação em Endocrinologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.; Laboratório de Fisiologia Endócrina Doris Rosenthal, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Andrade MN; Laboratório de Endocrinologia Experimental-LEEx, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.; Programa de Pós-graduação em Farmacologia e Química Medicinal, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Rumjanek VM; Laboratório de Imunologia Tumoral, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Miranda-Alves L; Laboratório de Endocrinologia Experimental-LEEx, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.; Programa de Pós-Graduação em Endocrinologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.; Programa de Pós-graduação em Farmacologia e Química Medicinal, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
de Carvalho DP; Programa de Pós-Graduação em Endocrinologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.; Laboratório de Fisiologia Endócrina Doris Rosenthal, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
de Paiva LS; Laboratório de Imunorregulação, Departamento de Imunobiologia, Instituto de Biologia, Universidade Federal Fluminense, Niterói, Brazil.; Programa de Pós-Graduação em Patologia, Universidade Federal Fluminense, Niterói, Brazil.
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Źródło :
Environmental toxicology [Environ Toxicol] 2021 Jul; Vol. 36 (7), pp. 1338-1348. Date of Electronic Publication: 2021 Mar 24.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Papillary*/drug therapy
Thyroid Neoplasms*/drug therapy
Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Epithelial-Mesenchymal Transition ; Humans ; Ouabain ; Thyroid Cancer, Papillary
Czasopismo naukowe
Tytuł :
Skeletal Muscle Na,K-ATPase as a Target for Circulating Ouabain.
Autorzy :
Kravtsova VV; Department of General Physiology, St. Petersburg State University, St. Petersburg 199034, Russia.
Bouzinova EV; Department of Biomedicine, University of Aarhus, Aarhus C 8000, Denmark.
Matchkov VV; Department of Biomedicine, University of Aarhus, Aarhus C 8000, Denmark.
Krivoi II; Department of General Physiology, St. Petersburg State University, St. Petersburg 199034, Russia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Apr 20; Vol. 21 (8). Date of Electronic Publication: 2020 Apr 20.
Typ publikacji :
Journal Article
MeSH Terms :
Muscle, Skeletal/*metabolism
Ouabain/*metabolism
Sodium-Potassium-Exchanging ATPase/*metabolism
Animals ; Blood Glucose ; Enzyme Activation ; Humans ; Isoenzymes/metabolism ; Kinetics ; Male ; Membrane Potentials/drug effects ; Muscle, Skeletal/drug effects ; Ouabain/blood ; Ouabain/pharmacology ; Rats ; Sheep ; Torpedo
Czasopismo naukowe
Tytuł :
Ouabain Enhances Gap Junctional Intercellular Communication by Inducing Paracrine Secretion of Prostaglandin E2.
Autorzy :
Ogazon Del Toro A; Department of Physiology, Biophysics and Neurosciences, CINVESTAV-IPN, Mexico City 07360, Mexico.
Jimenez L; Department of Physiology, Biophysics and Neurosciences, CINVESTAV-IPN, Mexico City 07360, Mexico.
Serrano Rubi M; Department of Physiology, Biophysics and Neurosciences, CINVESTAV-IPN, Mexico City 07360, Mexico.
Cereijido M; Department of Physiology, Biophysics and Neurosciences, CINVESTAV-IPN, Mexico City 07360, Mexico.
Ponce A; Department of Physiology, Biophysics and Neurosciences, CINVESTAV-IPN, Mexico City 07360, Mexico.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 10; Vol. 22 (12). Date of Electronic Publication: 2021 Jun 10.
Typ publikacji :
Journal Article
MeSH Terms :
Paracrine Communication*
Cardiotonic Agents/*pharmacology
Dinoprostone/*metabolism
Gap Junctions/*physiology
Ouabain/*pharmacology
Animals ; Dogs ; Madin Darby Canine Kidney Cells ; Signal Transduction
Czasopismo naukowe
Tytuł :
Quo vadis Cardiac Glycoside Research?
Autorzy :
Bejček J; Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Technická 5, Prague 6, Czech Republic.
Jurášek M; Department of Chemistry of Natural Compounds, University of Chemistry and Technology Prague, Technická 3, Prague 6, Czech Republic.
Spiwok V; Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Technická 5, Prague 6, Czech Republic.
Rimpelová S; Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Technická 5, Prague 6, Czech Republic.
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Źródło :
Toxins [Toxins (Basel)] 2021 May 11; Vol. 13 (5). Date of Electronic Publication: 2021 May 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Molecular Targeted Therapy*
Cardiac Glycosides/*pharmacology
Sodium-Potassium-Exchanging ATPase/*antagonists & inhibitors
Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/toxicity ; Cardiac Glycosides/biosynthesis ; Cardiac Glycosides/toxicity ; Cattle ; Digitoxin/pharmacology ; Digitoxin/toxicity ; Digoxin/pharmacology ; Digoxin/toxicity ; Humans ; Neoplasms/drug therapy ; Ouabain/pharmacology ; Ouabain/toxicity
Czasopismo naukowe
Tytuł :
Chronic Ouabain Prevents Na,K-ATPase Dysfunction and Targets AMPK and IL-6 in Disused Rat Soleus Muscle.
Autorzy :
Kravtsova VV; Department of General Physiology, St. Petersburg State University, 199034 St. Petersburg, Russia.
Paramonova II; Myology Laboratory, Institute of Biomedical Problems RAS, 123007 Moscow, Russia.
Vilchinskaya NA; Myology Laboratory, Institute of Biomedical Problems RAS, 123007 Moscow, Russia.
Tishkova MV; Department of General Physiology, St. Petersburg State University, 199034 St. Petersburg, Russia.
Matchkov VV; Department of Biomedicine, MEMBRANES, Health, University of Aarhus, C 8000 Aarhus, Denmark.
Shenkman BS; Myology Laboratory, Institute of Biomedical Problems RAS, 123007 Moscow, Russia.
Krivoi II; Department of General Physiology, St. Petersburg State University, 199034 St. Petersburg, Russia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 10; Vol. 22 (8). Date of Electronic Publication: 2021 Apr 10.
Typ publikacji :
Journal Article
MeSH Terms :
Interleukin-6/*genetics
Muscular Disorders, Atrophic/*drug therapy
Ouabain/*pharmacology
Protein Kinases/*genetics
Sodium-Potassium-Exchanging ATPase/*genetics
Acetyl-CoA Carboxylase/genetics ; Animals ; Hindlimb/drug effects ; Hindlimb/physiopathology ; Hindlimb Suspension ; Humans ; Interleukin-6/antagonists & inhibitors ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/physiopathology ; Muscular Disorders, Atrophic/genetics ; Muscular Disorders, Atrophic/pathology ; Organ Culture Techniques ; Protein Kinases/drug effects ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Cellular sensing platform with enhanced sensitivity based on optogenetic modulation of cell homeostasis.
Autorzy :
Gheorghiu M; International Centre of Biodynamics, Intr. Portocalelor 1 B, 060101, Bucharest, Romania; Faculty of Biology, University of Bucharest, 91-95 Splaiul Independentei, Bucharest, 050095, Romania. Electronic address: .
Stănică L; International Centre of Biodynamics, Intr. Portocalelor 1 B, 060101, Bucharest, Romania; Faculty of Biology, University of Bucharest, 91-95 Splaiul Independentei, Bucharest, 050095, Romania.
Ghinia Tegla MG; Institute for Interdisciplinary Research in Bio-Nano-Sciences, Molecular Biology Center, Babes-Bolyai-University, 400084, Cluj-Napoca, Romania; Retinal Circuit Development & Genetics Unit N-NRL/NEI/NIH 6 Center Drive Bethesda, 20892, Maryland, United States.
Polonschii C; International Centre of Biodynamics, Intr. Portocalelor 1 B, 060101, Bucharest, Romania. Electronic address: .
Bratu D; International Centre of Biodynamics, Intr. Portocalelor 1 B, 060101, Bucharest, Romania. Electronic address: .
Popescu O; Institute for Interdisciplinary Research in Bio-Nano-Sciences, Molecular Biology Center, Babes-Bolyai-University, 400084, Cluj-Napoca, Romania; Institute of Biology, Romanian Academy, 296 Splaiul Independentei, 060031, Bucharest, Romania.
Badea T; Retinal Circuit Development & Genetics Unit N-NRL/NEI/NIH 6 Center Drive Bethesda, 20892, Maryland, United States. Electronic address: .
Gheorghiu E; International Centre of Biodynamics, Intr. Portocalelor 1 B, 060101, Bucharest, Romania; Faculty of Biology, University of Bucharest, 91-95 Splaiul Independentei, Bucharest, 050095, Romania. Electronic address: .
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Źródło :
Biosensors & bioelectronics [Biosens Bioelectron] 2020 Apr 15; Vol. 154, pp. 112003. Date of Electronic Publication: 2019 Dec 31.
Typ publikacji :
Journal Article
MeSH Terms :
Biosensing Techniques*
Ions/*isolation & purification
Optogenetics/*methods
Ouabain/*isolation & purification
Homeostasis/genetics ; Humans ; Ions/chemistry ; Ouabain/chemistry
Czasopismo naukowe
Tytuł :
Sodium pumps, ouabain and aldosterone in the brain: A neuromodulatory pathway underlying salt-sensitive hypertension and heart failure.
Autorzy :
Leenen FHH; Brain and Heart Research Group, University of Ottawa Heart Institute, Ottawa, ON, Canada.
Wang HW; Brain and Heart Research Group, University of Ottawa Heart Institute, Ottawa, ON, Canada.
Hamlyn JM; Department of Physiology, University of Maryland, Baltimore, MD, USA. Electronic address: .
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Źródło :
Cell calcium [Cell Calcium] 2020 Mar; Vol. 86, pp. 102151. Date of Electronic Publication: 2019 Dec 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Aldosterone/*metabolism
Brain/*metabolism
Heart Failure/*metabolism
Hypertension/*metabolism
Ouabain/*metabolism
Sodium Chloride, Dietary/*adverse effects
Sodium-Potassium-Exchanging ATPase/*metabolism
Animals ; Heart Failure/blood ; Heart Failure/complications ; Heart Failure/physiopathology ; Humans ; Hypertension/blood ; Hypertension/complications ; Hypertension/physiopathology ; Ouabain/blood
Czasopismo naukowe
Tytuł :
The cardenolides ouabain and reevesioside A promote FGF2 secretion and subsequent FGFR1 phosphorylation via converged ERK1/2 activation.
Autorzy :
Zhao GH; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli 35053, Taiwan, ROC; Department of Life Sciences, National Central University, Taoyuan 32001, Taiwan, ROC.
Qiu YQ; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli 35053, Taiwan, ROC.
Yang CW; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli 35053, Taiwan, ROC.
Chen IS; School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC.
Chen CY; Department of Life Sciences, National Central University, Taoyuan 32001, Taiwan, ROC.
Lee SJ; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli 35053, Taiwan, ROC. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Feb; Vol. 172, pp. 113741. Date of Electronic Publication: 2019 Dec 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cardenolides/*pharmacology
Fibroblast Growth Factor 2/*agonists
Ouabain/*pharmacology
Receptor, Fibroblast Growth Factor, Type 1/*metabolism
A549 Cells ; Cardenolides/chemistry ; Cell Survival/drug effects ; Drug Interactions ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Gene Expression Regulation/drug effects ; Humans ; MAP Kinase Signaling System ; Molecular Structure ; Ouabain/chemistry ; Pyrroles/administration & dosage ; Pyrroles/pharmacology
Czasopismo naukowe
Tytuł :
Vacuolar H+-ATPase and Na+/K+-ATPase energize Na+ uptake mechanisms in the nuchal organ of the hyperregulating freshwater crustacean Daphnia magna.
Autorzy :
Morris C; Department of Biology, McMaster University, Hamilton, ON, Canada, L8S 4K1.
O'Donnell MJ; Department of Biology, McMaster University, Hamilton, ON, Canada, L8S 4K1.
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Źródło :
The Journal of experimental biology [J Exp Biol] 2021 Jun 15; Vol. 224 (12). Date of Electronic Publication: 2021 Jun 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Daphnia*/metabolism
Sodium-Potassium-Exchanging ATPase*
Vacuolar Proton-Translocating ATPases*
Animals ; Fresh Water ; Ouabain ; Sodium/metabolism
Czasopismo naukowe
Tytuł :
Intracerebroventricular injection of ouabain causes mania-like behavior in mice through D2 receptor activation.
Autorzy :
Lopachev A; Research Center of Neurology, Volokolamskoye shosse 80, 125367, Moscow, Russia. .
Volnova A; Institute of Translational Biomedicine, Saint Petersburg State University, Universitetskaya Emb. 7/9, 199034, St Petersburg, Russia.; Biological Department, Saint Petersburg State University, Universitetskaya Emb. 7/9, 199034, St Petersburg, Russia.
Evdokimenko A; Research Center of Neurology, Volokolamskoye shosse 80, 125367, Moscow, Russia.
Abaimov D; Research Center of Neurology, Volokolamskoye shosse 80, 125367, Moscow, Russia.
Timoshina Y; Biological Department, Lomonosov Moscow State University, Leninskiye Gory 1, 119991, Moscow, Russia.
Kazanskaya R; Biological Department, Saint Petersburg State University, Universitetskaya Emb. 7/9, 199034, St Petersburg, Russia.
Lopacheva O; Research Center of Neurology, Volokolamskoye shosse 80, 125367, Moscow, Russia.; International Biotechnological Center, Lomonosov Moscow State University, Leninskiye Gory 1, 119991, Moscow, Russia.
Deal A; Department of Neurobiology and Anatomy, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, 27157, North Carolina, USA.
Budygin E; Department of Neurobiology and Anatomy, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, 27157, North Carolina, USA.
Fedorova T; Research Center of Neurology, Volokolamskoye shosse 80, 125367, Moscow, Russia.
Gainetdinov R; Institute of Translational Biomedicine, Saint Petersburg State University, Universitetskaya Emb. 7/9, 199034, St Petersburg, Russia.
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Źródło :
Scientific reports [Sci Rep] 2019 Oct 30; Vol. 9 (1), pp. 15627. Date of Electronic Publication: 2019 Oct 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bipolar Disorder/*chemically induced
Ouabain/*adverse effects
Receptors, Dopamine D2/*metabolism
Animals ; Behavior, Animal ; Bipolar Disorder/genetics ; Bipolar Disorder/metabolism ; Bipolar Disorder/psychology ; Corpus Striatum/drug effects ; Corpus Striatum/metabolism ; Disease Models, Animal ; Dopamine/metabolism ; Glycogen Synthase Kinase 3 beta/genetics ; Glycogen Synthase Kinase 3 beta/metabolism ; Humans ; Male ; Mice ; Ouabain/administration & dosage ; Receptors, Dopamine D2/genetics ; Sodium-Potassium-Exchanging ATPase/genetics ; Sodium-Potassium-Exchanging ATPase/metabolism
Czasopismo naukowe
Tytuł :
Cardiac Oxidative Signaling and Physiological Hypertrophy in the Na/K-ATPase α1 Mouse Model of High Affinity for Cardiotonic Steroids.
Autorzy :
Marck PV; Marshall Institute for Interdisciplinary Research, Huntington, WV 25703, USA.
Pessoa MT; Marshall Institute for Interdisciplinary Research, Huntington, WV 25703, USA.
Xu Y; Marshall Institute for Interdisciplinary Research, Huntington, WV 25703, USA.
Kutz LC; Marshall Institute for Interdisciplinary Research, Huntington, WV 25703, USA.
Collins DM; Marshall Institute for Interdisciplinary Research, Huntington, WV 25703, USA.
Yan Y; Department of Biomedical Sciences, Marshall University Joan C. Edwards School of Medicine, Huntington, WV 25755, USA.
King C; Marshall Institute for Interdisciplinary Research, Huntington, WV 25703, USA.
Wang X; Marshall Institute for Interdisciplinary Research, Huntington, WV 25703, USA.
Duan Q; Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA.
Cai L; Marshall Institute for Interdisciplinary Research, Huntington, WV 25703, USA.
Xie JX; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Lingrel JB; Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Xie Z; Marshall Institute for Interdisciplinary Research, Huntington, WV 25703, USA.
Tian J; Marshall Institute for Interdisciplinary Research, Huntington, WV 25703, USA.
Pierre SV; Marshall Institute for Interdisciplinary Research, Huntington, WV 25703, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 27; Vol. 22 (7). Date of Electronic Publication: 2021 Mar 27.
Typ publikacji :
Journal Article
MeSH Terms :
Cardiac Glycosides/*chemistry
Heart/*physiology
Myocardium/*enzymology
Sodium-Potassium-Exchanging ATPase/*genetics
Angiotensin II/pharmacology ; Animals ; Cardiomegaly/pathology ; Disease Models, Animal ; Echocardiography ; Heart/drug effects ; Male ; Mice ; Mutation ; Ouabain/pharmacology ; Protein Isoforms ; RNA-Seq ; Reactive Oxygen Species ; Signal Transduction/drug effects
Czasopismo naukowe

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