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Tytuł :
Nature or nurture? Steady-state lymphocyte formation in adults does not recapitulate ontogeny.
Autorzy :
Kincade PW; Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA. />Owen JJ
Igarashi H
Kouro T
Yokota T
Rossi MI
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Źródło :
Immunological reviews [Immunol Rev] 2002 Sep; Vol. 187, pp. 116-25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review
MeSH Terms :
Lymphopoiesis*
Lymphocytes/*cytology
Stem Cells/*cytology
Animals ; Cell Lineage ; Fetus/cytology ; Humans ; Steroids/metabolism ; Thymus Gland/cytology
Czasopismo naukowe
Tytuł :
Imaging synapse formation during thymocyte selection: inability of CD3zeta to form a stable central accumulation during negative selection.
Autorzy :
Richie LI; Program in Immunology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Ebert PJ
Wu LC
Krummel MF
Owen JJ
Davis MM
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Źródło :
Immunity [Immunity] 2002 Apr; Vol. 16 (4), pp. 595-606.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
CD3 Complex/*immunology
T-Lymphocytes/*immunology
Animals ; CD3 Complex/genetics ; Cell Differentiation ; Green Fluorescent Proteins ; Image Processing, Computer-Assisted ; Luminescent Proteins/genetics ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/genetics ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/immunology ; Synapses ; T-Lymphocytes/cytology ; Thymus Gland/cytology ; Thymus Gland/immunology
Czasopismo naukowe
Tytuł :
Annotating the human proteome: the Human Proteome Survey Database (HumanPSD) and an in-depth target database for G protein-coupled receptors (GPCR-PD) from Incyte Genomics.
Autorzy :
Hodges PE; Incyte Genomics, Proteome Division, 100 Cummings Center, Suite 435M, Beverly, MA 01915, USA. />Carrico PM
Hogan JD
O'Neill KE
Owen JJ
Mangan M
Davis BP
Brooks JE
Garrels JI
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2002 Jan 01; Vol. 30 (1), pp. 137-41.
Typ publikacji :
Journal Article
MeSH Terms :
Databases, Protein*
Heterotrimeric GTP-Binding Proteins/*metabolism
Proteome/*genetics
Receptors, Cell Surface/*genetics
Amino Acid Sequence ; Animals ; Humans ; Information Storage and Retrieval ; Internet ; Ligands ; Mice ; Mutation ; Phenotype ; Protein Structure, Tertiary ; Proteome/chemistry ; Proteome/physiology ; Rats ; Receptors, Cell Surface/chemistry ; Receptors, Cell Surface/physiology ; Sequence Alignment ; Signal Transduction ; Vocabulary, Controlled
Czasopismo naukowe
Tytuł :
Development of the thymus requires signaling through the fibroblast growth factor receptor R2-IIIb.
Autorzy :
Revest JM; Imperial Cancer Research Fund, London, UK.
Suniara RK
Kerr K
Owen JJ
Dickson C
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2001 Aug 15; Vol. 167 (4), pp. 1954-61.
Typ publikacji :
Journal Article
MeSH Terms :
Receptor Protein-Tyrosine Kinases/*physiology
Receptors, Fibroblast Growth Factor/*physiology
Signal Transduction/*immunology
Thymus Gland/*growth & development
Thymus Gland/*immunology
Animals ; Cell Differentiation/genetics ; Cell Differentiation/immunology ; Cell Division/genetics ; Cell Division/immunology ; Culture Techniques ; DNA-Binding Proteins/biosynthesis ; DNA-Binding Proteins/genetics ; Epithelium/pathology ; Female ; Fibroblast Growth Factor 10 ; Fibroblast Growth Factor 7 ; Fibroblast Growth Factors/biosynthesis ; Fibroblast Growth Factors/genetics ; Gene Deletion ; Male ; Mice ; Mice, Knockout ; PAX9 Transcription Factor ; Paired Box Transcription Factors ; Protein Isoforms/biosynthesis ; Protein Isoforms/deficiency ; Protein Isoforms/genetics ; Protein Isoforms/physiology ; Receptor Protein-Tyrosine Kinases/biosynthesis ; Receptor Protein-Tyrosine Kinases/deficiency ; Receptor Protein-Tyrosine Kinases/genetics ; Receptor, Fibroblast Growth Factor, Type 2 ; Receptors, Fibroblast Growth Factor/biosynthesis ; Receptors, Fibroblast Growth Factor/deficiency ; Receptors, Fibroblast Growth Factor/genetics ; Signal Transduction/genetics ; T-Lymphocytes/pathology ; Thymus Gland/abnormalities ; Thymus Gland/metabolism ; Transcription Factors/biosynthesis ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
An essential role for thymic mesenchyme in early T cell development.
Autorzy :
Suniara RK; Department of Anatomy, Division of Immunity and Infection, Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom. />Jenkinson EJ
Owen JJ
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Źródło :
The Journal of experimental medicine [J Exp Med] 2000 Mar 20; Vol. 191 (6), pp. 1051-6.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Mesoderm/*physiology
T-Lymphocytes/*cytology
Thymus Gland/*embryology
Thymus Gland/*immunology
Animals ; Cell Differentiation/immunology ; Cell Movement/immunology ; Epithelial Cells/cytology ; Epithelial Cells/immunology ; Extracellular Matrix/immunology ; Extracellular Matrix/physiology ; Hematopoiesis, Extramedullary/immunology ; Lymphoid Tissue/cytology ; Lymphoid Tissue/embryology ; Lymphoid Tissue/immunology ; Mesoderm/cytology ; Mesoderm/immunology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Organ Culture Techniques ; Stem Cells/cytology ; Stem Cells/immunology ; T-Lymphocyte Subsets/cytology ; T-Lymphocytes/immunology ; Thymus Gland/cytology ; Thymus Gland/growth & development
Czasopismo naukowe
Tytuł :
The role of mesenchyme in thymus development.
Autorzy :
Owen JJ; Department of Anatomy, Medical School, University of Birmingham, Edgbaston, UK.
McLoughlin DE
Suniara RK
Jenkinson EJ
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Źródło :
Current topics in microbiology and immunology [Curr Top Microbiol Immunol] 2000; Vol. 251, pp. 133-7.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cell Communication*
Fibroblasts/*cytology
Mesoderm/*cytology
T-Lymphocytes/*cytology
Thymus Gland/*embryology
Czasopismo naukowe
Tytuł :
Specialized ability of thymic epithelial cells to mediate positive selection does not require expression of the steroidogenic enzyme p450scc.
Autorzy :
Jenkinson EJ; Department of Anatomy, Division of Immunity and Infection, Medical Research Council Centre for Immune Regulation, Medical School, University of Birmingham, Edgbaston, Birmingham, United Kingdom. />Parnell S
Shuttleworth J
Owen JJ
Anderson G
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 1999 Dec 01; Vol. 163 (11), pp. 5781-5.
Typ publikacji :
Journal Article
MeSH Terms :
Cholesterol Side-Chain Cleavage Enzyme/*biosynthesis
Epithelial Cells/*immunology
Glucocorticoids/*metabolism
Thymus Gland/*immunology
Animals ; Antigens, CD ; Antigens, Differentiation, T-Lymphocyte ; Cell Aggregation ; Cell Differentiation ; Cholesterol Side-Chain Cleavage Enzyme/genetics ; Embryo, Mammalian/immunology ; Histocompatibility Antigens Class II ; Lectins, C-Type ; Mice ; Mice, Inbred BALB C ; Organ Culture Techniques ; RNA, Messenger/biosynthesis ; Receptors, Antigen, T-Cell/metabolism ; Signal Transduction ; Stromal Cells ; Thymus Gland/cytology ; Thymus Gland/embryology
Czasopismo naukowe
Tytuł :
Cellular and matrix interactions during the development of T lymphocytes.
Autorzy :
Owen JJ; Department of Anatomy, Medical School, University of Birmingham, Edgbaston, UK. />McLoughlin DE
Suniara RK
Jenkinson EJ
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Źródło :
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas [Braz J Med Biol Res] 1999 May; Vol. 32 (5), pp. 551-5.
Typ publikacji :
Journal Article
MeSH Terms :
Fibroblasts*
T-Lymphocytes*
Thymus Gland*/cytology
Extracellular Matrix Proteins/*physiology
Epithelial Cells ; Interleukin-2 ; Interleukin-7
Czasopismo naukowe
Tytuł :
Studies on thymic epithelial cells in vitro.
Autorzy :
Anderson KL; Anatomy Department, Medical School, University of Birmingham, UK.
Moore NC
McLoughlin DE
Jenkinson EJ
Owen JJ
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Źródło :
Developmental and comparative immunology [Dev Comp Immunol] 1998 May-Jun; Vol. 22 (3), pp. 367-77.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epithelial Cells/*cytology
Thymus Gland/*cytology
Animals ; Cell Division ; Cells, Cultured ; Epithelial Cells/metabolism ; Gene Expression ; Histocompatibility Antigens Class II ; Mice ; Mice, Inbred BALB C ; Thymus Gland/embryology
Czasopismo naukowe
Tytuł :
Cellular interactions in the thymus regulate the protein kinase C signaling pathway.
Autorzy :
Porritt HE; Department of Anatomy, Medical School, University of Birmingham, GB. />Anderson KL
Suniara RK
Jenkinson EJ
Owen JJ
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Źródło :
European journal of immunology [Eur J Immunol] 1998 Apr; Vol. 28 (4), pp. 1197-203.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Communication/*physiology
Protein Kinase C/*physiology
Signal Transduction/*physiology
Thymus Gland/*cytology
Thymus Gland/*physiology
Animals ; CD4 Antigens/biosynthesis ; Carcinogens/pharmacology ; Cell Communication/drug effects ; Immunohistochemistry ; Mice ; Mice, Inbred BALB C ; Organ Culture Techniques ; Signal Transduction/drug effects ; Tetradecanoylphorbol Acetate/pharmacology
Czasopismo naukowe
Tytuł :
Anti-alpha 4 integrin antibody induces apoptosis in murine thymocytes and staphylococcal enterotoxin B-activated lymph node T cells.
Autorzy :
Tchilian EZ; Centre for Clinical Research in Immunology and Signalling/Department of Anatomy, Medical School, University of Birmingham, UK.
Owen JJ
Jenkinson EJ
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Źródło :
Immunology [Immunology] 1997 Nov; Vol. 92 (3), pp. 321-7.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigens, CD/*immunology
Apoptosis/*immunology
Enterotoxins/*immunology
Superantigens/*immunology
T-Lymphocyte Subsets/*immunology
Animals ; Apoptosis/drug effects ; Female ; Indoles/pharmacology ; Integrin alpha4 ; Lymph Nodes/immunology ; Lymphocyte Activation/immunology ; Maleimides/pharmacology ; Mice ; Mice, Inbred BALB C ; Protein Kinase C/antagonists & inhibitors ; Staphylococcus aureus/immunology ; Thymus Gland/immunology
Czasopismo naukowe
Tytuł :
Fibroblast dependency during early thymocyte development maps to the CD25+ CD44+ stage and involves interactions with fibroblast matrix molecules.
Autorzy :
Anderson G; Department of Anatomy/Centre for Clinical Research in Immunology and Signalling, Medical School, University of Birmingham, GB. />Anderson KL
Tchilian EZ
Owen JJ
Jenkinson EJ
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Źródło :
European journal of immunology [Eur J Immunol] 1997 May; Vol. 27 (5), pp. 1200-6.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Communication/*immunology
Extracellular Matrix Proteins/*metabolism
Hyaluronan Receptors/*analysis
Receptors, Interleukin-2/*analysis
T-Lymphocyte Subsets/*cytology
Thymus Gland/*cytology
3T3 Cells ; Animals ; Animals, Newborn ; Antibodies, Monoclonal/immunology ; Antigens, CD/immunology ; CD4 Antigens/analysis ; CD8 Antigens/analysis ; Cell Aggregation/immunology ; Cell Differentiation/immunology ; Ethyldimethylaminopropyl Carbodiimide ; Extracellular Matrix Proteins/biosynthesis ; Fibroblasts/immunology ; Hematopoietic Stem Cells/immunology ; Hyaluronan Receptors/immunology ; Hyaluronoglucosaminidase ; Integrin alpha4 ; Mice ; Mice, Inbred BALB C ; Rabbits ; Stromal Cells/immunology ; T-Lymphocyte Subsets/immunology ; Thymus Gland/embryology ; Thymus Gland/growth & development
Czasopismo naukowe
Tytuł :
Intracellular signaling pathways involved in the induction of apoptosis in immature thymic T lymphocytes.
Autorzy :
Anderson KL; Center for Clinical Research in Immunology and Signaling and Department of Anatomy, University of Birmingham, Birmingham, United Kingdom.
Anderson G
Michell RH
Jenkinson EJ
Owen JJ
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 1996 Jun 01; Vol. 156 (11), pp. 4083-91.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*/drug effects
Signal Transduction*
T-Lymphocytes/*cytology
T-Lymphocytes/*immunology
Adrenergic beta-Agonists/pharmacology ; Animals ; Animals, Newborn ; Antibodies/pharmacology ; Bucladesine/pharmacology ; CD3 Complex/metabolism ; Cell Differentiation ; Concanavalin A/pharmacology ; Cyclic AMP/metabolism ; In Vitro Techniques ; Isoproterenol/pharmacology ; Mice ; Mice, Inbred BALB C ; Phosphatidylinositols/metabolism ; Protein Synthesis Inhibitors/pharmacology ; Serine Proteinase Inhibitors/pharmacology ; T-Lymphocytes/metabolism ; fas Receptor/metabolism
Czasopismo naukowe
Tytuł :
Involvement of LFA-1/ICAM-2 adhesive interactions and PKC in activation-induced cell death following SEB rechallenge.
Autorzy :
Tchilian EZ; Department of Anatomy/Centre for Clinical Research in Immunology and Signalling, University of Birmingham, UK.
Anderson G
Moore NC
Owen JJ
Jenkinson EJ
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Źródło :
Immunology [Immunology] 1996 Apr; Vol. 87 (4), pp. 566-72.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigens, CD/*immunology
Apoptosis/*immunology
Cell Adhesion Molecules/*immunology
Enterotoxins/*immunology
Lymphocyte Function-Associated Antigen-1/*immunology
Protein Kinase C/*immunology
Animals ; Antigen-Presenting Cells/immunology ; B7-1 Antigen/analysis ; Cell Culture Techniques ; Female ; Guinea Pigs ; Histocompatibility Antigens Class II/analysis ; Lymph Nodes/immunology ; Lymphocyte Activation ; Mice ; Mice, Inbred BALB C ; T-Lymphocytes/immunology
Czasopismo naukowe
Tytuł :
Cellular interactions in thymocyte development.
Autorzy :
Anderson G; Department of Anatomy, Medical School, University of Birmingham, United Kingdom.
Moore NC
Owen JJ
Jenkinson EJ
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Źródło :
Annual review of immunology [Annu Rev Immunol] 1996; Vol. 14, pp. 73-99.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cell Communication/*immunology
T-Lymphocytes/*cytology
T-Lymphocytes/*physiology
Thymus Gland/*cytology
Animals ; Cell Differentiation/immunology ; Humans ; T-Lymphocytes/immunology ; Thymus Gland/immunology
Czasopismo naukowe
Tytuł :
Positive selection of thymocytes involves sustained interactions with the thymic microenvironment.
Autorzy :
Wilkinson RW; Department of Anatomy/Center for Clinical Research in Immunology and Signaling, Medical School, University of Birmingham, United Kingdom.
Anderson G
Owen JJ
Jenkinson EJ
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 1995 Dec 01; Vol. 155 (11), pp. 5234-40.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CD4-Positive T-Lymphocytes/*cytology
CD8-Positive T-Lymphocytes/*cytology
Thymus Gland/*cytology
Animals ; Antigens, CD/immunology ; Antigens, Differentiation, T-Lymphocyte/immunology ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cell Differentiation/physiology ; Clonal Deletion ; Epithelium/physiology ; Lectins, C-Type ; Mice ; Mice, Inbred BALB C ; Stromal Cells/physiology ; Superantigens/immunology ; Thymus Gland/embryology ; Thymus Gland/growth & development ; Thymus Gland/immunology
Czasopismo naukowe
Tytuł :
Stimulation of thymocytes before and after positive selection results in the induction of different NF-kappa B/Rel protein complexes.
Autorzy :
Moore NC; Centre for Clinical Research in Immunology & Signalling, Medical School, University of Birmingham, United Kingdom.
Girdlestone J
Anderson G
Owen JJ
Jenkinson EJ
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 1995 Nov 15; Vol. 155 (10), pp. 4653-60.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Lymphocyte Activation*
CD4-Positive T-Lymphocytes/*immunology
CD8-Positive T-Lymphocytes/*immunology
NF-kappa B/*biosynthesis
Receptors, Antigen, T-Cell/*immunology
Amino Acid Sequence ; Animals ; Base Sequence ; Cell Differentiation ; Gene Expression Regulation ; Mice ; Mice, Inbred BALB C ; Molecular Sequence Data ; T-Lymphocyte Subsets
Czasopismo naukowe
Tytuł :
Phosphatidylinositol 4,5-bisphosphate hydrolysis accompanies T cell receptor-induced apoptosis of murine thymocytes within the thymus.
Autorzy :
Conroy LA; Centre for Clinical Research in Immunology and Signalling, Medical School, University of Birmingham, GB.
Jenkinson EJ
Owen JJ
Michell RH
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Źródło :
European journal of immunology [Eur J Immunol] 1995 Jul; Vol. 25 (7), pp. 1828-35.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Inositol Phosphates/*metabolism
Phosphatidylinositol Phosphates/*metabolism
Phosphatidylinositols/*metabolism
Receptors, Antigen, T-Cell/*physiology
T-Lymphocyte Subsets/*physiology
Thymus Gland/*cytology
Aluminum Compounds/pharmacology ; Animals ; Cells, Cultured ; Enzyme Activation ; Fluorides/pharmacology ; Ionomycin/pharmacology ; Lymphocyte Activation ; Mice ; Organ Culture Techniques ; Phorbol Esters/pharmacology ; Phosphatidylinositol 4,5-Diphosphate ; Protein Kinase C/physiology ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Signal Transduction ; T-Lymphocyte Subsets/cytology
Czasopismo naukowe

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