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Wyszukujesz frazę ""PC12 cells"" wg kryterium: Temat


Tytuł :
4-PBA Enhances Autophagy by Inhibiting Endoplasmic Reticulum Stress in Recombinant Human Beta Nerve Growth Factor-Induced PC12 cells After Mechanical Injury via PI3K/AKT/mTOR Signaling Pathway.
Autorzy :
Wang Z; Department of Orthopedics, Fujian Medical University Union Hospital, Fuzhou, P.R. China.
Zheng S; Department of Orthopedics, Fujian Medical University Union Hospital, Fuzhou, P.R. China.
Gu Y; Department of Orthopedics, Fujian Medical University Union Hospital, Fuzhou, P.R. China.
Zhou L; Department of Orthopedics, Fujian Medical University Union Hospital, Fuzhou, P.R. China.
Lin B; Department of Orthopedics, Fujian Medical University Union Hospital, Fuzhou, P.R. China.
Liu W; Department of Orthopedics, Fujian Medical University Union Hospital, Fuzhou, P.R. China. Electronic address: .
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Źródło :
World neurosurgery [World Neurosurg] 2020 Jun; Vol. 138, pp. e659-e664. Date of Electronic Publication: 2020 Mar 14.
Typ publikacji :
Journal Article
MeSH Terms :
PC12 Cells*
Autophagy/*drug effects
Endoplasmic Reticulum Stress/*drug effects
Nerve Growth Factor/*pharmacology
Phenylbutyrates/*pharmacology
Signal Transduction/*drug effects
Animals ; Chromones/pharmacology ; Humans ; Microtubule-Associated Proteins/metabolism ; Morpholines/pharmacology ; Oncogene Protein v-akt/drug effects ; Phosphatidylinositol 3-Kinases/drug effects ; Phosphorylation ; Rats ; Recombinant Proteins/pharmacology ; Spinal Cord Injuries/drug therapy ; TOR Serine-Threonine Kinases/drug effects
Czasopismo naukowe
Tytuł :
Anemarrhenae asphodeloides rhizoma Extract Enriched in Mangiferin Protects PC12 Cells against a Neurotoxic Agent-3-Nitropropionic Acid.
Autorzy :
Piwowar A; Department of Toxicology, Wroclaw Medical University, 211 50556 Borowska, Poland.
Rembiałkowska N; Department of Molecular and Cellular Biology, Wroclaw Medical University, 211A 50556 Borowska, Poland.
Rorbach-Dolata A; Department of Toxicology, Wroclaw Medical University, 211 50556 Borowska, Poland.
Garbiec A; Department of Developmental Biology, Institute of Experimental Biology, University of Wroclaw, ul. H. 21 50335 Sienkiewicza, Poland.
Ślusarczyk S; Department of Pharmaceutical Biology and Botany, Wroclaw Medical University, 211 50556 Borowska, Poland.
Dobosz A; Department of Basic Medical Sciences, Wroclaw Medical University, 211 50556 Borowska, Poland.
Długosz A; Department of Toxicology, Wroclaw Medical University, 211 50556 Borowska, Poland.
Marchewka Z; Department of Toxicology, Wroclaw Medical University, 211 50556 Borowska, Poland.
Matkowski A; Department of Pharmaceutical Biology and Botany, Wroclaw Medical University, 211 50556 Borowska, Poland.
Saczko J; Department of Molecular and Cellular Biology, Wroclaw Medical University, 211A 50556 Borowska, Poland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Apr 04; Vol. 21 (7). Date of Electronic Publication: 2020 Apr 04.
Typ publikacji :
Journal Article
MeSH Terms :
Anemarrhena/*chemistry
Neuroprotective Agents/*pharmacology
Nitro Compounds/*adverse effects
PC12 Cells/*cytology
Propionates/*adverse effects
Xanthones/*pharmacology
Animals ; Apoptosis/drug effects ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacology ; Molecular Structure ; Neuroprotective Agents/chemistry ; PC12 Cells/drug effects ; Rats ; Rhizome/chemistry ; Time Factors ; Xanthones/chemistry
Czasopismo naukowe
Tytuł :
Dexmedetomidine protects PC12 cells from oxidative damage through regulation of miR-199a/HIF-1α.
Autorzy :
Wu L; Department of Clinical Pharmacy, Dalian Central Hospital, Dalian, China.
Xi Y; Department of Clinical Pharmacy, Dalian Central Hospital, Dalian, China.
Kong Q; Department of Thoracic Surgery, Dalian Central Hospital, Dalian, China.
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Źródło :
Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2020 Dec; Vol. 48 (1), pp. 506-514.
Typ publikacji :
Journal Article
MeSH Terms :
Dexmedetomidine/*pharmacokinetics
Gene Expression Regulation/*drug effects
Hypoxia-Inducible Factor 1, alpha Subunit/*genetics
MicroRNAs/*genetics
Oxidative Stress/*drug effects
Animals ; Apoptosis/drug effects ; Cell Survival/drug effects ; Hydrogen Peroxide/toxicity ; Oxidative Stress/genetics ; PC12 Cells ; Rats ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Comparative assessment of neurotoxicity impacts induced by alkyl tri-n-butyl phosphate and aromatic tricresyl phosphate in PC12 cells.
Autorzy :
Chang Y; State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, China.
Cui H; State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, China.
Jiang X; State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, China.
Li M; State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, China.
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Źródło :
Environmental toxicology [Environ Toxicol] 2020 Dec; Vol. 35 (12), pp. 1326-1333. Date of Electronic Publication: 2020 Jul 14.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Flame Retardants/*toxicity
Neurons/*drug effects
Organophosphates/*toxicity
Tritolyl Phosphates/*toxicity
Acetylcholinesterase/metabolism ; Animals ; Caspase 3/metabolism ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Neurons/enzymology ; Neurons/pathology ; PC12 Cells ; Rats
Czasopismo naukowe
Tytuł :
Silencing PAQR3 protects against oxygen-glucose deprivation/reperfusion-induced neuronal apoptosis via activation of PI3K/AKT signaling in PC12 cells.
Autorzy :
Qiao S; Department of Neurosurgery, Shenzhen Second People's Hospital/the First Affiliated Hospital of Shenzhen University Health Science Center, Graduate School of Guangzhou Medical University, Shenzhen 518035, China.
Yang D; Department of Neurosurgery, Shenzhen Second People's Hospital/the First Affiliated Hospital of Shenzhen University Health Science Center, Graduate School of Guangzhou Medical University, Shenzhen 518035, China.
Li X; The Central Laboratory, Shenzhen Second People's Hospital/the First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen 518035, China.
Li W; Department of Neurosurgery, Shenzhen Second People's Hospital/the First Affiliated Hospital of Shenzhen University Health Science Center, Graduate School of Guangzhou Medical University, Shenzhen 518035, China.
Zhang Y; Department of Neurosurgery, Shenzhen Second People's Hospital/the First Affiliated Hospital of Shenzhen University Health Science Center, Graduate School of Guangzhou Medical University, Shenzhen 518035, China; The Central Laboratory, Shenzhen Second People's Hospital/the First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen 518035, China. Electronic address: .
Liu W; Department of Neurosurgery, Shenzhen Second People's Hospital/the First Affiliated Hospital of Shenzhen University Health Science Center, Graduate School of Guangzhou Medical University, Shenzhen 518035, China; The Central Laboratory, Shenzhen Second People's Hospital/the First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen 518035, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jan 15; Vol. 265, pp. 118806. Date of Electronic Publication: 2020 Nov 26.
Typ publikacji :
Journal Article
MeSH Terms :
Brain Ischemia/*metabolism
Glucose/*deficiency
Intracellular Signaling Peptides and Proteins/*biosynthesis
Membrane Proteins/*biosynthesis
Phosphatidylinositol 3-Kinases/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Reperfusion Injury/*metabolism
Animals ; Apoptosis/physiology ; Brain Ischemia/genetics ; Brain Ischemia/prevention & control ; Cell Hypoxia/physiology ; Gene Silencing/physiology ; Intracellular Signaling Peptides and Proteins/deficiency ; Intracellular Signaling Peptides and Proteins/genetics ; Male ; Membrane Proteins/deficiency ; Membrane Proteins/genetics ; Mice ; Mice, Inbred C57BL ; Neurons/metabolism ; PC12 Cells ; Rats ; Reperfusion Injury/genetics ; Reperfusion Injury/prevention & control
Czasopismo naukowe
Tytuł :
PEGylated CuInS 2 /ZnS quantum dots inhibit neurite outgrowth by downregulating the NGF/p75 /MAPK pathway.
Autorzy :
Yang Z; Base for International Science and Technology Cooperation: Carson Cancer Stem Cell Vaccines R&D Center, Shenzhen Key Lab of Synthetic Biology, Department of Physiology, School of Basic Medical Sciences Shenzhen University, Shenzhen, 518055, China.
Zou W; Base for International Science and Technology Cooperation: Carson Cancer Stem Cell Vaccines R&D Center, Shenzhen Key Lab of Synthetic Biology, Department of Physiology, School of Basic Medical Sciences Shenzhen University, Shenzhen, 518055, China.
Pan Y; Department of Disease Prevention and Control, Shenzhen Baoan District Health Bureau, Shenzhen, China.
Yong KT; School of Electrical and Electronic Engineering, Nanyang Technological University, 639798, Singapore.
Li L; Base for International Science and Technology Cooperation: Carson Cancer Stem Cell Vaccines R&D Center, Shenzhen Key Lab of Synthetic Biology, Department of Physiology, School of Basic Medical Sciences Shenzhen University, Shenzhen, 518055, China.
Wang X; Base for International Science and Technology Cooperation: Carson Cancer Stem Cell Vaccines R&D Center, Shenzhen Key Lab of Synthetic Biology, Department of Physiology, School of Basic Medical Sciences Shenzhen University, Shenzhen, 518055, China.
Liu D; Base for International Science and Technology Cooperation: Carson Cancer Stem Cell Vaccines R&D Center, Shenzhen Key Lab of Synthetic Biology, Department of Physiology, School of Basic Medical Sciences Shenzhen University, Shenzhen, 518055, China.
Chen T; Base for International Science and Technology Cooperation: Carson Cancer Stem Cell Vaccines R&D Center, Shenzhen Key Lab of Synthetic Biology, Department of Physiology, School of Basic Medical Sciences Shenzhen University, Shenzhen, 518055, China.
Xue D; Base for International Science and Technology Cooperation: Carson Cancer Stem Cell Vaccines R&D Center, Shenzhen Key Lab of Synthetic Biology, Department of Physiology, School of Basic Medical Sciences Shenzhen University, Shenzhen, 518055, China.
Lin G; Base for International Science and Technology Cooperation: Carson Cancer Stem Cell Vaccines R&D Center, Shenzhen Key Lab of Synthetic Biology, Department of Physiology, School of Basic Medical Sciences Shenzhen University, Shenzhen, 518055, China. Electronic address: .
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2021 Jan 01; Vol. 207, pp. 111378. Date of Electronic Publication: 2020 Oct 03.
Typ publikacji :
Journal Article
MeSH Terms :
Neuronal Outgrowth/*drug effects
Quantum Dots/*toxicity
Animals ; Cadmium/pharmacology ; Down-Regulation/drug effects ; Humans ; Mitogen-Activated Protein Kinase 3 ; Nerve Growth Factor ; Nerve Tissue Proteins ; PC12 Cells ; Rats ; Receptors, Nerve Growth Factor ; Signal Transduction/drug effects ; Sulfides ; Toxicity Tests ; Zinc Compounds
Czasopismo naukowe
Tytuł :
Selenium modulates inorganic mercury induced cytotoxicity and intrinsic apoptosis in PC12 cells.
Autorzy :
Hossain KFB; Graduate School of Environmental Science, Hokkaido University, Sapporo, 060-0810, Japan.
Rahman MM; Department of Environmental Sciences, Jahangirnagar University, Dhaka, 1342, Bangladesh.
Sikder MT; Department of Public Health and Informatics, Jahangirnagar University, Dhaka, 1342, Bangladesh.
Hosokawa T; Institute for the Advancement of Higher Education, Hokkaido University, Sapporo, 060-0817, Japan.
Saito T; Faculty of Health Science, Hokkaido University, Sapporo, 060-0812, Japan.
Kurasaki M; Graduate School of Environmental Science, Hokkaido University, Sapporo, 060-0810, Japan; Faculty of Environmental Earth Science, Hokkaido University, Sapporo, 060-0810, Japan. Electronic address: .
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2021 Jan 01; Vol. 207, pp. 111262. Date of Electronic Publication: 2020 Sep 08.
Typ publikacji :
Journal Article
MeSH Terms :
Hazardous Substances/*toxicity
Mercury/*toxicity
Protective Agents/*pharmacology
Selenium/*pharmacology
Animals ; Antioxidants/metabolism ; Apoptosis/drug effects ; Caspase 3 ; Cytochromes c/metabolism ; Glutathione/metabolism ; Humans ; Mercury/metabolism ; Oxidative Stress/drug effects ; PC12 Cells ; Rats ; Signal Transduction/drug effects ; TOR Serine-Threonine Kinases
Czasopismo naukowe
Tytuł :
Zinc-pretreatment triggers glutathione and Nrf2-mediated protection against inorganic mercury-induced cytotoxicity and intrinsic apoptosis in PC12 cells.
Autorzy :
Hossain KFB; Graduate School of Environmental Science, Hokkaido University, Sapporo, 060-0810, Japan. Electronic address: .
Hosokawa T; Institute for the Advancement of Higher Education, Hokkaido University, Sapporo, 060-0817, Japan.
Saito T; Faculty of Health Sciences, Hokkaido University, Sapporo, 060-0812, Japan.
Kurasaki M; Graduate School of Environmental Science, Hokkaido University, Sapporo, 060-0810, Japan; Faculty of Environmental Earth Science, Hokkaido University, Sapporo, 060-0810, Japan.
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2021 Jan 01; Vol. 207, pp. 111320. Date of Electronic Publication: 2020 Sep 15.
Typ publikacji :
Journal Article
MeSH Terms :
Glutathione/*metabolism
Mercury/*toxicity
NF-E2-Related Factor 2/*metabolism
Zinc/*metabolism
Animals ; Antioxidants/metabolism ; Apoptosis/drug effects ; Caspase 3 ; Cell Survival/drug effects ; Humans ; PC12 Cells ; Proto-Oncogene Proteins c-bcl-2 ; Rats ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Ablation of TMEM126B protects against oxygen-glucose deprivation/reoxygenation-induced injuries of PC12 cells via maintaining mitochondrial anti-apoptotic functions.
Autorzy :
Wei L; Department of Neurology, Jiaozuo People's Hospital, Jiaozuo, Henan, 454002, China.
Fan Y; Department of Neurology, Jiaozuo People's Hospital, Jiaozuo, Henan, 454002, China.
Wei L; Department of Neurology, Jiaozuo People's Hospital, Jiaozuo, Henan, 454002, China.
He X; Department of Neurology, Jiaozuo People's Hospital, Jiaozuo, Henan, 454002, China.
Yang J; Department of Neurology, Jiaozuo People's Hospital, Jiaozuo, Henan, 454002, China.
Zheng X; Department of Neurology, Jiaozuo People's Hospital, Jiaozuo, Henan, 454002, China. Electronic address: .
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Źródło :
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2020 Dec 15; Vol. 696, pp. 108634. Date of Electronic Publication: 2020 Oct 16.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*physiology
Cell Hypoxia/*physiology
Glucose/*metabolism
Membrane Proteins/*metabolism
Mitochondria/*metabolism
Reperfusion Injury/*metabolism
Adult ; Aged ; Aged, 80 and over ; Animals ; Cerebral Infarction/metabolism ; Female ; Gene Knockdown Techniques ; Humans ; Male ; Malondialdehyde/metabolism ; Membrane Proteins/genetics ; Middle Aged ; Oxidative Stress/genetics ; PC12 Cells ; Rats ; Reactive Oxygen Species/metabolism ; Superoxide Dismutase/metabolism ; Up-Regulation
Czasopismo naukowe
Tytuł :
Selenium-Doped Carbon Quantum Dots Efficiently Ameliorate Secondary Spinal Cord Injury via Scavenging Reactive Oxygen Species.
Autorzy :
Luo W; Department of Orthopaedic Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, People's Republic of China.; Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China.
Wang Y; Department of Orthopaedic Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, People's Republic of China.; Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China.
Lin F; Department of Orthopaedic Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, People's Republic of China.; Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China.
Liu Y; Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China.; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, People's Republic of China.
Gu R; Department of Orthopaedic Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, People's Republic of China.
Liu W; Department of Orthopaedic Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, People's Republic of China.
Xiao C; Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China.; Jilin Biomedical Polymers Engineering Laboratory, Changchun 130022, People's Republic of China.
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Źródło :
International journal of nanomedicine [Int J Nanomedicine] 2020 Dec 14; Vol. 15, pp. 10113-10125. Date of Electronic Publication: 2020 Dec 14 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Carbon/*chemistry
Quantum Dots/*chemistry
Reactive Oxygen Species/*metabolism
Selenium/*pharmacology
Spinal Cord Injuries/*pathology
Animals ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Antioxidants/pharmacology ; Apoptosis/drug effects ; Astrocytes/drug effects ; Astrocytes/pathology ; Disease Models, Animal ; Female ; Mice ; Motor Activity/drug effects ; Neuroglia/drug effects ; Neuroglia/pathology ; Neuroprotection/drug effects ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; PC12 Cells ; Quantum Dots/ultrastructure ; Rats ; Rats, Sprague-Dawley ; Recovery of Function/drug effects ; Spinal Cord/drug effects ; Spinal Cord/pathology ; Spinal Cord/physiopathology ; Spinal Cord Injuries/drug therapy ; Spinal Cord Injuries/physiopathology
Czasopismo naukowe
Tytuł :
MiR-211 protects cerebral ischemia/reperfusion injury by inhibiting cell apoptosis.
Autorzy :
Liu W; Department of Anesthesia, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Miao Y; Department of Medical Network Information Center, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Zhang L; Department of Anesthesia, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Xu X; Department of Anesthesia, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Luan Q; Department of Anesthesia, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
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Źródło :
Bioengineered [Bioengineered] 2020 Dec; Vol. 11 (1), pp. 189-200.
Typ publikacji :
Journal Article
MeSH Terms :
MicroRNAs/*metabolism
Reperfusion Injury/*metabolism
Reperfusion Injury/*therapy
Animals ; Apoptosis/genetics ; Apoptosis/physiology ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism ; Blotting, Western ; Brain/metabolism ; Flow Cytometry ; In Situ Nick-End Labeling ; Male ; Mice, Inbred C57BL ; MicroRNAs/genetics ; Neurons/metabolism ; PC12 Cells ; Rats ; Reperfusion Injury/genetics
Czasopismo naukowe
Tytuł :
Protocatechuic aldehyde mitigates hydrogen peroxide-triggered PC12 cell damage by down-regulating MEG3.
Autorzy :
Zhong Z; Department of Pain, China-Japan Union Hospital of Jilin University, Jilin, China.
Yao X; Department of Pathology, Changchun Medical College, Jilin, China.
Luo M; Department of Pain, China-Japan Union Hospital of Jilin University, Jilin, China.
Li M; Department of Medical Insurance Management, China-Japan Union Hospital of Jilin University, Jilin, China.
Dong L; Department of Pain, China-Japan Union Hospital of Jilin University, Jilin, China.
Zhang Z; Department of Orthopedics, The Second Hospital of Jilin University, Jilin, China.
Jiang R; Department of Orthopedics, China-Japan Union Hospital of Jilin University, Jilin, China.
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Źródło :
Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2020 Dec; Vol. 48 (1), pp. 602-609.
Typ publikacji :
Journal Article
MeSH Terms :
Benzaldehydes/*pharmacology
Catechols/*pharmacology
Down-Regulation/*drug effects
Hydrogen Peroxide/*toxicity
RNA, Long Noncoding/*genetics
Animals ; Apoptosis/drug effects ; Autophagy/drug effects ; Cell Survival/drug effects ; Down-Regulation/genetics ; PC12 Cells ; PTEN Phosphohydrolase/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Signal Transduction/drug effects ; Wnt Proteins/metabolism ; beta Catenin/metabolism
Czasopismo naukowe
Tytuł :
miR-22 protect PC12 from ischemia/reperfusion-induced injury by targeting p53 upregulated modulator of apoptosis (PUMA).
Autorzy :
Jiao H; Department of Anesthesia, Linyi Cancer Hospital, Linyi, Shandong, China.
Chen R; Department of Anesthesia, Linyi Cancer Hospital, Linyi, Shandong, China.
Jiang Z; External Abdominal Section, Linyi Cancer Hospital, Linyi, Shandong, China.
Zhang L; Department of Anesthesia, Linyi Cancer Hospital, Linyi, Shandong, China.
Wang H; Department of Anesthesia, Linyi Cancer Hospital, Linyi, Shandong, China.
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Źródło :
Bioengineered [Bioengineered] 2020 Dec; Vol. 11 (1), pp. 209-218.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis Regulatory Proteins/*metabolism
MicroRNAs/*metabolism
Myocardial Reperfusion Injury/*metabolism
Reperfusion Injury/*metabolism
Tumor Suppressor Protein p53/*metabolism
Animals ; Apoptosis ; Apoptosis Regulatory Proteins/genetics ; Blotting, Western ; In Situ Nick-End Labeling ; MicroRNAs/genetics ; Myocardial Reperfusion Injury/genetics ; Myocardial Reperfusion Injury/pathology ; PC12 Cells ; Rats ; Reperfusion Injury/genetics ; Reperfusion Injury/pathology ; Tumor Suppressor Protein p53/genetics
Czasopismo naukowe
Tytuł :
In vitro and in vivo evaluation of didymin cyclodextrin inclusion complexes: characterization and chemosensitization activity.
Autorzy :
Yao Q; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Lin MT; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Lan QH; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Huang ZW; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Zheng YW; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Jiang X; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Zhu YD; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Kou L; Department of Pharmacy, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Xu HL; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Zhao YZ; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
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Źródło :
Drug delivery [Drug Deliv] 2020 Dec; Vol. 27 (1), pp. 54-65.
Typ publikacji :
Journal Article
MeSH Terms :
2-Hydroxypropyl-beta-cyclodextrin/*chemistry
Flavonoids/*administration & dosage
Flavonoids/*pharmacology
Glycosides/*administration & dosage
Glycosides/*pharmacology
Technology, Pharmaceutical/*methods
beta-Cyclodextrins/*chemistry
Animals ; Calorimetry, Differential Scanning ; Flavonoids/pharmacokinetics ; Glycosides/pharmacokinetics ; Human Umbilical Vein Endothelial Cells ; Humans ; MCF-7 Cells ; Male ; PC12 Cells ; Rats ; Solubility ; Spectroscopy, Fourier Transform Infrared ; X-Ray Diffraction
Czasopismo naukowe
Tytuł :
Design, synthesis, in vitro and in vivo evaluation of benzylpiperidine-linked 1,3-dimethylbenzimidazolinones as cholinesterase inhibitors against Alzheimer's disease.
Autorzy :
Mo J; School of Pharmacy, China Pharmaceutical University, Nanjing, People's Republic of China.
Chen T; Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, People's Republic of China.
Yang H; School of Pharmacy, China Pharmaceutical University, Nanjing, People's Republic of China.
Guo Y; School of pharmacy, Yantai University, Yantai, People's Republic of China.
Li Q; School of Pharmacy, China Pharmaceutical University, Nanjing, People's Republic of China.
Qiao Y; School of Pharmacy, China Pharmaceutical University, Nanjing, People's Republic of China.
Lin H; School of Pharmacy, China Pharmaceutical University, Nanjing, People's Republic of China.
Feng F; Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, People's Republic of China.; Jiangsu Food and Pharmaceutical Science College, Huaian, People's Republic of China.
Liu W; School of Pharmacy, China Pharmaceutical University, Nanjing, People's Republic of China.
Chen Y; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.
Liu Z; Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, People's Republic of China.
Sun H; School of Pharmacy, China Pharmaceutical University, Nanjing, People's Republic of China.; Jiangsu Food and Pharmaceutical Science College, Huaian, People's Republic of China.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 330-343.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Alzheimer Disease/*drug therapy
Antioxidants/*pharmacology
Benzimidazoles/*pharmacology
Cholinesterase Inhibitors/*pharmacology
Acetylcholinesterase/metabolism ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/antagonists & inhibitors ; Amyloid beta-Peptides/metabolism ; Animals ; Antioxidants/chemical synthesis ; Antioxidants/chemistry ; Benzimidazoles/chemical synthesis ; Benzimidazoles/chemistry ; Butyrylcholinesterase/metabolism ; Cell Death/drug effects ; Cell Survival/drug effects ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Electrophorus ; Hep G2 Cells ; Horses ; Humans ; Mice ; Mice, Inbred ICR ; Models, Molecular ; Molecular Structure ; PC12 Cells ; Peptide Fragments/antagonists & inhibitors ; Peptide Fragments/metabolism ; Protein Aggregates/drug effects ; Rats ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Silencing MEG3 protects PC12 cells from hypoxic injury by targeting miR-21.
Autorzy :
Deng D; Department of Neurology, Daqing Oilfield General Hospital, Daqing, China.
Liang H; Department of Neurology, Hainan General Hospital, Haikou, China.
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Źródło :
Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2020 Dec; Vol. 48 (1), pp. 610-619.
Typ publikacji :
Journal Article
MeSH Terms :
RNA Interference*
Hypoxia/*prevention & control
MicroRNAs/*genetics
RNA, Long Noncoding/*genetics
Animals ; Apoptosis ; Cell Survival ; Gene Expression Regulation ; Hypoxia/genetics ; Hypoxia/metabolism ; Hypoxia/pathology ; MicroRNAs/metabolism ; NF-kappa B/metabolism ; PC12 Cells ; Phosphatidylinositol 3-Kinases ; Proto-Oncogene Proteins c-akt ; Rats ; Signal Transduction
Czasopismo naukowe
Tytuł :
TRPV4 contributes to ER stress: Relation to apoptosis in the MPP -induced cell model of Parkinson's disease.
Autorzy :
Liu N; Faculty of Life science and Technology, Kunming University of Science and Technology, Kunming 650500, China; Department of Anesthesiology, The First People's Hospital of Yunnan Province, Kunming 650032, China.
Liu J; Medical School, Kunming University of Science and Technology, Kunming 650500, China.
Wen X; Medical School, Kunming University of Science and Technology, Kunming 650500, China.
Bai L; Faculty of Life science and Technology, Kunming University of Science and Technology, Kunming 650500, China.
Shao R; Medical School, Kunming University of Science and Technology, Kunming 650500, China.
Bai J; Medical School, Kunming University of Science and Technology, Kunming 650500, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Nov 15; Vol. 261, pp. 118461. Date of Electronic Publication: 2020 Sep 19.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
Endoplasmic Reticulum Stress*
Parkinson Disease, Secondary/*pathology
TRPV Cation Channels/*metabolism
1-Methyl-4-phenylpyridinium ; Animals ; Cell Survival ; PC12 Cells ; Parkinson Disease, Secondary/genetics ; Parkinson Disease, Secondary/metabolism ; Rats ; TRPV Cation Channels/analysis ; TRPV Cation Channels/genetics ; Up-Regulation
Czasopismo naukowe
Tytuł :
Fostered Nrf2 expression antagonizes iron overload and glutathione depletion to promote resistance of neuron-like cells to ferroptosis.
Autorzy :
Liu Z; Key Laboratory of Luminescence Analysis and Molecular Sensing, Southwest University, Ministry of Education, College of Pharmaceutical Sciences, Chongqing 400715, People's Republic of China.
Lv X; Key Laboratory of Luminescence Analysis and Molecular Sensing, Southwest University, Ministry of Education, College of Pharmaceutical Sciences, Chongqing 400715, People's Republic of China.
Song E; Key Laboratory of Luminescence Analysis and Molecular Sensing, Southwest University, Ministry of Education, College of Pharmaceutical Sciences, Chongqing 400715, People's Republic of China.
Song Y; Key Laboratory of Luminescence Analysis and Molecular Sensing, Southwest University, Ministry of Education, College of Pharmaceutical Sciences, Chongqing 400715, People's Republic of China. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2020 Nov 15; Vol. 407, pp. 115241. Date of Electronic Publication: 2020 Sep 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ferroptosis/*drug effects
Glutathione/*biosynthesis
Iron Overload/*drug therapy
NF-E2-Related Factor 2/*biosynthesis
Neurons/*drug effects
Amino Acid Transport Systems, Acidic/biosynthesis ; Amino Acid Transport Systems, Acidic/genetics ; Animals ; Gene Knockdown Techniques ; Glutathione/deficiency ; Iron/metabolism ; Lipid Peroxidation/drug effects ; NF-E2-Related Factor 2/drug effects ; PC12 Cells ; RNA, Small Interfering ; Rats
Czasopismo naukowe
Tytuł :
A new oleanane type pentacyclic triterpenoid saponin from the husks of xanthoceras sorbifolium bunge and its neuroprotection on PC12 cells injury induced by Aβ 25-35 .
Autorzy :
Ding K; School of Pharmacy, Shenyang Parmaceutical University, Shenyang, China.
Guo S; School of Pharmacy, Shenyang Parmaceutical University, Shenyang, China.
Rong W; School of Traditional Chinese Materia Medica, Shenyang Parmaceutical University, Shenyang, China.
Li Q; School of Pharmacy, Shenyang Parmaceutical University, Shenyang, China.
Liu R; School of Pharmacy, Shenyang Parmaceutical University, Shenyang, China.
Xu H; School of Pharmacy, Shenyang Parmaceutical University, Shenyang, China.
Yin Y; School of Pharmacy, Shenyang Parmaceutical University, Shenyang, China.
Bi K; School of Pharmacy, Shenyang Parmaceutical University, Shenyang, China.
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Źródło :
Natural product research [Nat Prod Res] 2020 Nov; Vol. 34 (22), pp. 3212-3218. Date of Electronic Publication: 2019 May 28.
Typ publikacji :
Journal Article
MeSH Terms :
Amyloid beta-Peptides/*toxicity
Neuroprotective Agents/*chemistry
Neuroprotective Agents/*pharmacology
Peptide Fragments/*toxicity
Sapindaceae/*chemistry
Animals ; Cell Survival/drug effects ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Neuroprotective Agents/isolation & purification ; Nuts/chemistry ; Oleanolic Acid/analogs & derivatives ; Oleanolic Acid/chemistry ; PC12 Cells/drug effects ; Rats ; Saponins/chemistry ; Spectrometry, Mass, Electrospray Ionization ; Triterpenes/chemistry ; Triterpenes/pharmacology
Czasopismo naukowe
Tytuł :
MiR-29a-3p Enhances the Viability of Rat Neuronal Cells that Injured by Oxygen-Glucose Deprivation/Reoxygenation Treatment Through Targeting TNFRSF1A and Regulating NF-κB Signaling Pathway.
Autorzy :
Gao XZ; Department of Anesthesiology, Affiliated Hospital of North China University of Science and Technology, Tangshan, Hebei 063000, P.R. China.
Zhang ZX; Department of Geriatrics, Shanxian centrol Hospital, Heze, Shandong 274300, P.R. China.
Han GL; Department of Neurosurgery, Shengli Oilfield Central Hospital of Binzhou Medical College, Dongying, Shandong 257034, P.R. China. Electronic address: .
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Źródło :
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association [J Stroke Cerebrovasc Dis] 2020 Nov; Vol. 29 (11), pp. 105210. Date of Electronic Publication: 2020 Aug 08.
Typ publikacji :
Journal Article
MeSH Terms :
MicroRNAs/*metabolism
NF-kappa B/*metabolism
Neurons/*metabolism
Receptors, Tumor Necrosis Factor, Type I/*metabolism
Reperfusion Injury/*metabolism
Animals ; Apoptosis ; Cell Hypoxia ; Cell Proliferation ; Cell Survival ; Databases, Genetic ; Glucose/deficiency ; Humans ; MicroRNAs/genetics ; Neurons/pathology ; PC12 Cells ; Phosphorylation ; Rats ; Receptors, Tumor Necrosis Factor, Type I/genetics ; Reperfusion Injury/genetics ; Reperfusion Injury/pathology ; Signal Transduction ; Up-Regulation
Czasopismo naukowe

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