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Tytuł :
Polyethylenimine (PEI)-modified poly (lactic-co-glycolic) acid (PLGA) nanoparticles conjugated with tumor-homing bacteria facilitate high intensity focused ultrasound-mediated tumor ablation.
Autorzy :
Wang D; State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, People's Republic of China; Chongqing Key Laboratory of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
Jiang F; State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, People's Republic of China; Chongqing Key Laboratory of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
Wang L; State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, People's Republic of China; Chongqing Key Laboratory of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
Tang Y; State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, People's Republic of China; Chongqing Key Laboratory of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
Zhang Z; State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, People's Republic of China; Chongqing Key Laboratory of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
Du Y; State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, People's Republic of China; Chongqing Key Laboratory of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
Zou J; State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, People's Republic of China; Chongqing Key Laboratory of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, People's Republic of China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Sep 24; Vol. 571, pp. 104-109. Date of Electronic Publication: 2021 Jul 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Bifidobacterium bifidum/*isolation & purification
Breast Neoplasms/*drug therapy
Breast Neoplasms/*microbiology
Nanoparticles/*chemistry
Polyethyleneimine/*pharmacology
Polylactic Acid-Polyglycolic Acid Copolymer/*pharmacology
Animals ; Antineoplastic Agents/chemistry ; Breast Neoplasms/pathology ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor ; Female ; Mice ; Mice, Inbred BALB C ; Polyethyleneimine/chemistry ; Polylactic Acid-Polyglycolic Acid Copolymer/chemistry ; Ultrasonic Waves
Czasopismo naukowe
Tytuł :
An overview of PLGA in-situ forming implants based on solvent exchange technique: effect of formulation components and characterization.
Autorzy :
Ibrahim TM; Department of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
El-Megrab NA; Department of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
El-Nahas HM; Department of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
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Źródło :
Pharmaceutical development and technology [Pharm Dev Technol] 2021 Sep; Vol. 26 (7), pp. 709-728. Date of Electronic Publication: 2021 Jun 27.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Compounding*/methods
Polylactic Acid-Polyglycolic Acid Copolymer*
Drug Implants/*pharmacokinetics
Humans ; Injections, Intramuscular
Czasopismo naukowe
Tytuł :
Evaluation of cytotoxic and genotoxic effects of paclitaxel-loaded PLGA nanoparticles in neuroblastoma cells.
Autorzy :
Bacanlı M; University of Health Sciences Turkey, Gülhane Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Ankara, Turkey. Electronic address: .
Eşi M Ö; University of Health Sciences Turkey, Gülhane Faculty of Pharmacy, Department of Pharmaceutical Technology Ankara, Turkey.
Erdoğan H; University of Health Sciences Turkey, Gülhane Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ankara, Turkey.
Sarper M; University of Health Sciences Turkey, Gülhane Institute of Health Sciences, Stem Cell Research Center, Ankara, Turkey.
Erdem O; University of Health Sciences Turkey, Gülhane Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Ankara, Turkey.
Özkan Y; University of Health Sciences Turkey, Gülhane Faculty of Pharmacy, Department of Pharmaceutical Technology Ankara, Turkey.
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Źródło :
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2021 Aug; Vol. 154, pp. 112323. Date of Electronic Publication: 2021 Jun 07.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Phytogenic/*toxicity
Nanoparticles/*chemistry
Neuroblastoma/*pathology
Paclitaxel/*toxicity
Polylactic Acid-Polyglycolic Acid Copolymer/*chemistry
Antineoplastic Agents, Phytogenic/administration & dosage ; Cell Line, Tumor ; Comet Assay ; Humans ; Nanoparticles/administration & dosage ; Paclitaxel/administration & dosage ; Polylactic Acid-Polyglycolic Acid Copolymer/administration & dosage
Czasopismo naukowe
Tytuł :
Nerve conduit based on HAP/PDLLA/PRGD for peripheral nerve regeneration with sustained release of valproic acid.
Autorzy :
Wu F; Department of Orthopedics, Renmin Hospital, Wuhan University, Wuhan, Hubei, China.
Jiao C; Department of Orthopedics,  Yangxin People's Hospital, Huangshi, Hubei, China.
Yang Y; Department of Orthopedics, Renmin Hospital, Wuhan University, Wuhan, Hubei, China.
Liu F; Department of Orthopedics, Renmin Hospital, Wuhan University, Wuhan, Hubei, China.
Sun Z; Department of Orthopedics, Renmin Hospital, Wuhan University, Wuhan, Hubei, China.
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Źródło :
Cell biology international [Cell Biol Int] 2021 Aug; Vol. 45 (8), pp. 1733-1742. Date of Electronic Publication: 2021 May 03.
Typ publikacji :
Journal Article
MeSH Terms :
Biocompatible Materials/*pharmacokinetics
Durapatite/*pharmacokinetics
Nerve Regeneration/*drug effects
Polylactic Acid-Polyglycolic Acid Copolymer/*pharmacokinetics
Sciatic Nerve/*drug effects
Valproic Acid/*pharmacokinetics
Animals ; Animals, Newborn ; Biocompatible Materials/administration & dosage ; Cells, Cultured ; Delayed-Action Preparations/administration & dosage ; Delayed-Action Preparations/pharmacokinetics ; Drug Liberation/drug effects ; Drug Liberation/physiology ; Durapatite/administration & dosage ; Male ; Nerve Regeneration/physiology ; Polyesters/administration & dosage ; Polyesters/pharmacokinetics ; Polylactic Acid-Polyglycolic Acid Copolymer/administration & dosage ; Rats ; Rats, Wistar ; Schwann Cells/drug effects ; Schwann Cells/metabolism ; Sciatic Nerve/metabolism ; Valproic Acid/administration & dosage
Czasopismo naukowe
Tytuł :
Paclitaxel-loaded and folic acid-modified PLGA nanomedicine with glutathione response for the treatment of lung cancer.
Autorzy :
Yao W; Oncology Institute of Traditional Chinese Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Yao J; Oncology Institute of Traditional Chinese Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Qian F; Oncology Institute of Traditional Chinese Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Que Z; Oncology Institute of Traditional Chinese Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Yu P; Oncology Institute of Traditional Chinese Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Luo T; Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Zheng D; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Zhang Z; Oncology Institute of Traditional Chinese Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Tian J; Oncology Institute of Traditional Chinese Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.; Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.; Research Center for Cancer, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China.
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Źródło :
Acta biochimica et biophysica Sinica [Acta Biochim Biophys Sin (Shanghai)] 2021 Jul 28; Vol. 53 (8), pp. 1027-1036.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Lewis Lung*/drug therapy
Carcinoma, Lewis Lung*/metabolism
Carcinoma, Lewis Lung*/pathology
Folic Acid*/chemistry
Folic Acid*/pharmacokinetics
Folic Acid*/pharmacology
Lung Neoplasms*/drug therapy
Lung Neoplasms*/metabolism
Lung Neoplasms*/pathology
Nanomedicine*
Paclitaxel*/chemistry
Paclitaxel*/pharmacokinetics
Paclitaxel*/pharmacology
Polylactic Acid-Polyglycolic Acid Copolymer*/chemistry
Polylactic Acid-Polyglycolic Acid Copolymer*/pharmacokinetics
Polylactic Acid-Polyglycolic Acid Copolymer*/pharmacology
Glutathione/*metabolism
Animals ; Delayed-Action Preparations/chemistry ; Delayed-Action Preparations/pharmacokinetics ; Delayed-Action Preparations/pharmacology ; Mice
Czasopismo naukowe
Tytuł :
Conformable hierarchically engineered polymeric micromeshes enabling combinatorial therapies in brain tumours.
Autorzy :
Di Mascolo D; Laboratory of Nanotechnology for Precision Medicine, Fondazione Istituto Italiano di Tecnologia, Genoa, Italy.
Palange AL; Laboratory of Nanotechnology for Precision Medicine, Fondazione Istituto Italiano di Tecnologia, Genoa, Italy.
Primavera R; Laboratory of Nanotechnology for Precision Medicine, Fondazione Istituto Italiano di Tecnologia, Genoa, Italy.; Interventional Regenerative Medicine and Imaging Laboratory, Department of Radiology, Stanford University, Palo Alto, CA, USA.
Macchi F; Laboratory of Nanotechnology for Precision Medicine, Fondazione Istituto Italiano di Tecnologia, Genoa, Italy.
Catelani T; Laboratory of Nanotechnology for Precision Medicine, Fondazione Istituto Italiano di Tecnologia, Genoa, Italy.; Microscopy Facility, University of Milano-Bicocca, Milan, Italy.
Piccardi F; Laboratory of Nanotechnology for Precision Medicine, Fondazione Istituto Italiano di Tecnologia, Genoa, Italy.
Spanò R; Laboratory of Nanotechnology for Precision Medicine, Fondazione Istituto Italiano di Tecnologia, Genoa, Italy.
Ferreira M; Laboratory of Nanotechnology for Precision Medicine, Fondazione Istituto Italiano di Tecnologia, Genoa, Italy.
Marotta R; Electron Microscopy Facility, Fondazione Istituto Italiano di Tecnologia, Genoa, Italy.
Armirotti A; Analytical Chemistry Lab, Fondazione Istituto Italiano di Tecnologia, Genoa, Italy.
Gallotti AL; Neural Stem Cell Biology Unit, Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy.
Galli R; Neural Stem Cell Biology Unit, Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy.
Wilson C; Department of Neurosurgery, Stanford University, Palo Alto, CA, USA.
Grant GA; Department of Neurosurgery, Stanford University, Palo Alto, CA, USA.
Decuzzi P; Laboratory of Nanotechnology for Precision Medicine, Fondazione Istituto Italiano di Tecnologia, Genoa, Italy. .
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Źródło :
Nature nanotechnology [Nat Nanotechnol] 2021 Jul; Vol. 16 (7), pp. 820-829. Date of Electronic Publication: 2021 Apr 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Absorbable Implants*
Antineoplastic Combined Chemotherapy Protocols*/pharmacokinetics
Antineoplastic Combined Chemotherapy Protocols*/pharmacology
Polylactic Acid-Polyglycolic Acid Copolymer*/pharmacokinetics
Polylactic Acid-Polyglycolic Acid Copolymer*/pharmacology
Brain Neoplasms/*drug therapy
Animals ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Cell Line ; Diclofenac/pharmacokinetics ; Diclofenac/pharmacology ; Docetaxel/pharmacokinetics ; Docetaxel/pharmacology ; Drug Implants/pharmacokinetics ; Drug Implants/pharmacology ; Female ; Humans ; Mice ; Mice, Nude ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
PLGA Nanoparticles Decorated with Anti-HER2 Affibody for Targeted Delivery and Photoinduced Cell Death.
Autorzy :
Shipunova VO; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., 117997 Moscow, Russia.; Institute of Engineering Physics for Biomedicine (PhysBio), MEPhI (Moscow Engineering Physics Institute), 31 Kashirskoe Shosse, 115409 Moscow, Russia.; Moscow Institute of Physics and Technology, 9 Institutskiy per., 141701 Dolgoprudny, Russia.; Department of Nanobiomedicine, Sirius University of Science and Technology, 1 Olympic Ave, 354340 Sochi, Russia.
Sogomonyan AS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., 117997 Moscow, Russia.; Institute of Engineering Physics for Biomedicine (PhysBio), MEPhI (Moscow Engineering Physics Institute), 31 Kashirskoe Shosse, 115409 Moscow, Russia.
Zelepukin IV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., 117997 Moscow, Russia.; Institute of Engineering Physics for Biomedicine (PhysBio), MEPhI (Moscow Engineering Physics Institute), 31 Kashirskoe Shosse, 115409 Moscow, Russia.; Moscow Institute of Physics and Technology, 9 Institutskiy per., 141701 Dolgoprudny, Russia.
Nikitin MP; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., 117997 Moscow, Russia.; Moscow Institute of Physics and Technology, 9 Institutskiy per., 141701 Dolgoprudny, Russia.; Department of Nanobiomedicine, Sirius University of Science and Technology, 1 Olympic Ave, 354340 Sochi, Russia.
Deyev SM; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., 117997 Moscow, Russia.; Institute of Engineering Physics for Biomedicine (PhysBio), MEPhI (Moscow Engineering Physics Institute), 31 Kashirskoe Shosse, 115409 Moscow, Russia.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Jun 28; Vol. 26 (13). Date of Electronic Publication: 2021 Jun 28.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Delivery Systems*
Nanoparticles*/chemistry
Nanoparticles*/therapeutic use
Polylactic Acid-Polyglycolic Acid Copolymer*/chemistry
Polylactic Acid-Polyglycolic Acid Copolymer*/pharmacology
Recombinant Fusion Proteins*/chemistry
Recombinant Fusion Proteins*/pharmacology
Neoplasms/*therapy
Receptor, ErbB-2/*metabolism
A549 Cells ; Animals ; CHO Cells ; Cell Death/drug effects ; Cricetulus ; Humans ; Neoplasms/metabolism ; Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Recombinant ArgF PLGA nanoparticles enhances BCG induced immune responses against Mycobacterium bovis infection.
Autorzy :
Ni J; Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Liu Y; Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Hussain T; Animal Health, The University of Agriculture Peshawar, 25000, Pakistan.
Li M; Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Liang Z; Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Liu T; Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing, China. Electronic address: .
Zhou X; Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing, China. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 May; Vol. 137, pp. 111341. Date of Electronic Publication: 2021 Feb 06.
Typ publikacji :
Journal Article
MeSH Terms :
Mycobacterium bovis*/growth & development
Mycobacterium bovis*/pathogenicity
BCG Vaccine/*administration & dosage
BCG Vaccine/*immunology
Nanoparticles/*administration & dosage
Ornithine Carbamoyltransferase/*immunology
Polylactic Acid-Polyglycolic Acid Copolymer/*immunology
Tuberculosis, Bovine/*prevention & control
Administration, Intranasal ; Animals ; Antibody Formation/drug effects ; Body Weight/drug effects ; CD4-Positive T-Lymphocytes/metabolism ; Cattle ; Cell Line ; Disease Models, Animal ; Female ; Immunoglobulin A, Secretory/metabolism ; Immunoglobulin G/blood ; Interferon-gamma/metabolism ; Interleukin-10/blood ; Interleukin-1beta/blood ; Lung/metabolism ; Lung/microbiology ; Lung/pathology ; Macrophages/drug effects ; Macrophages/immunology ; Mice, Inbred BALB C ; Nanoparticles/chemistry ; Ornithine Carbamoyltransferase/administration & dosage ; Ornithine Carbamoyltransferase/chemistry ; Polylactic Acid-Polyglycolic Acid Copolymer/administration & dosage ; Polylactic Acid-Polyglycolic Acid Copolymer/chemistry ; Recombinant Proteins/administration & dosage ; Recombinant Proteins/chemistry ; Recombinant Proteins/immunology ; Spleen/microbiology ; Spleen/pathology ; Tumor Necrosis Factor-alpha/blood
Czasopismo naukowe
Tytuł :
Investigating the Acoustic Response and Contrast Enhancement of Drug-Loadable PLGA Microparticles with Various Shapes and Morphologies.
Autorzy :
Gupta I; School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637459.
Su X; School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637459.
Jonnalagadda US; School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637459.
Das D; School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637459.
Pramanik M; School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637459.
Kwan JJ; School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637459. Electronic address: .
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Źródło :
Ultrasound in medicine & biology [Ultrasound Med Biol] 2021 Jul; Vol. 47 (7), pp. 1844-1856. Date of Electronic Publication: 2021 Mar 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acoustics*
Contrast Media*
Drug Delivery Systems*
Nanoparticles*
Polylactic Acid-Polyglycolic Acid Copolymer*
Czasopismo naukowe
Tytuł :
The composite microbeads of alginate, carrageenan, gelatin, and poly(lactic-co-glycolic acid): Synthesis, characterization and Density Functional Theory calculations.
Autorzy :
Baybaş D; Sivas Cumhuriyet University, Faculty of Science, Biochem. Dep., 58140 Sivas, Turkey. Electronic address: .
Serdaroğlu G; Sivas Cumhuriyet University, Math. and Sci. Edu., 58140 Sivas, Turkey.
Semerci B; Organized Industrial Zone, 2. Section, 5. Cad., No: 10, Sivas 58060, Turkey.
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Jun 30; Vol. 181, pp. 322-338. Date of Electronic Publication: 2021 Mar 26.
Typ publikacji :
Journal Article
MeSH Terms :
Density Functional Theory*
Microspheres*
Alginates/*chemistry
Carrageenan/*chemistry
Gelatin/*chemistry
Polylactic Acid-Polyglycolic Acid Copolymer/*chemistry
Alginates/chemical synthesis ; Carrageenan/chemical synthesis ; Gelatin/chemical synthesis ; Hydrogen-Ion Concentration ; Molecular Conformation ; Particle Size ; Polylactic Acid-Polyglycolic Acid Copolymer/chemical synthesis ; Quantum Theory ; Spectroscopy, Fourier Transform Infrared ; Static Electricity ; Temperature ; Thermogravimetry ; Vibration
Czasopismo naukowe
Tytuł :
PLGA-particle vaccine carrying TLR3/RIG-I ligand Riboxxim synergizes with immune checkpoint blockade for effective anti-cancer immunotherapy.
Autorzy :
Koerner J; Division of Immunology, Department of Biology, University of Konstanz, Konstanz, Germany.
Horvath D; Division of Immunology, Department of Biology, University of Konstanz, Konstanz, Germany.; Centre for the Advanced Study of Collective Behaviour, University of Konstanz, Konstanz, Germany.
Herrmann VL; Division of Immunology, Department of Biology, University of Konstanz, Konstanz, Germany.; Boehringer Ingelheim Pharma, Cancer Immunology + Immune Modulation, Biberach/ Riß, Germany.
MacKerracher A; Division of Immunology, Department of Biology, University of Konstanz, Konstanz, Germany.
Gander B; Institute of Pharmaceutical Sciences, ETH Zürich, Zürich, Switzerland.
Yagita H; Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan.
Rohayem J; Riboxx GmbH, BioInnovationszentrum, Dresden, Germany.; Institute of Virology, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.
Groettrup M; Division of Immunology, Department of Biology, University of Konstanz, Konstanz, Germany. .; Centre for the Advanced Study of Collective Behaviour, University of Konstanz, Konstanz, Germany. .; Biotechnology Institute Thurgau at the University of Konstanz (BITg), Kreuzlingen, Switzerland. .
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Źródło :
Nature communications [Nat Commun] 2021 May 18; Vol. 12 (1), pp. 2935. Date of Electronic Publication: 2021 May 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cancer Vaccines/*immunology
DEAD Box Protein 58/*immunology
Immune Checkpoint Inhibitors/*immunology
Immunotherapy/*methods
Neoplasms, Experimental/*therapy
Polylactic Acid-Polyglycolic Acid Copolymer/*immunology
Receptors, Immunologic/*immunology
Toll-Like Receptor 3/*immunology
Animals ; Cancer Vaccines/administration & dosage ; Cell Line, Tumor ; Cells, Cultured ; DEAD Box Protein 58/metabolism ; Drug Synergism ; Female ; Humans ; Immune Checkpoint Inhibitors/administration & dosage ; Ligands ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Transgenic ; Microscopy, Electron, Scanning ; Nanoparticles/chemistry ; Nanoparticles/ultrastructure ; Neoplasms, Experimental/immunology ; Neoplasms, Experimental/metabolism ; Polylactic Acid-Polyglycolic Acid Copolymer/chemistry ; Receptors, Immunologic/metabolism ; THP-1 Cells ; Toll-Like Receptor 3/metabolism ; Treatment Outcome
Czasopismo naukowe
Tytuł :
PLGA nanoparticles containing α-fetoprotein siRNA induce apoptosis and enhance the cytotoxic effects of doxorubicin in human liver cancer cell line.
Autorzy :
Pho-Iam T; Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.
Punnakitikashem P; Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand; Research Network NANOTEC-MU in Theranostic Nanomedicine, Thailand.
Somboonyosdech C; Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.
Sripinitchai S; Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.
Masaratana P; Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand; Research Network NANOTEC-MU in Theranostic Nanomedicine, Thailand.
Sirivatanauksorn V; Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand; Research Network NANOTEC-MU in Theranostic Nanomedicine, Thailand.
Sirivatanauksorn Y; Research Network NANOTEC-MU in Theranostic Nanomedicine, Thailand; Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.
Wongwan C; Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.
Nguyen KT; Department of Bioengineering, University of Texas at Arlington, Arlington, TX, 76019, USA.
Srisawat C; Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand; Research Network NANOTEC-MU in Theranostic Nanomedicine, Thailand. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 May 14; Vol. 553, pp. 191-197. Date of Electronic Publication: 2021 Mar 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Polylactic Acid-Polyglycolic Acid Copolymer*
Apoptosis/*genetics
Doxorubicin/*pharmacology
Liver Neoplasms/*drug therapy
Liver Neoplasms/*pathology
Nanoparticles/*chemistry
RNA, Small Interfering/*genetics
alpha-Fetoproteins/*genetics
Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/pathology ; Hep G2 Cells ; Humans ; Nanoparticles/therapeutic use ; RNA, Small Interfering/pharmacology
Czasopismo naukowe
Tytuł :
Enhanced immunogenicity of foot and mouth disease DNA vaccine delivered by PLGA nanoparticles combined with cytokine adjuvants.
Autorzy :
Yang Y; College of Animal Science and Technology, Hainan University, Hainan Key Lab of Tropical Animal Reproduction and Breeding and Epidemic Disease Research, Haidian Island, Haikou 570228, China.
Teng Z; State Key Laboratory of Veterinary Etiological Biology, National Foot-and-mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
Lu Y; State Key Laboratory of Veterinary Etiological Biology, National Foot-and-mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
Luo X; State Key Laboratory of Veterinary Etiological Biology, National Foot-and-mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
Mu S; State Key Laboratory of Veterinary Etiological Biology, National Foot-and-mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
Ru J; State Key Laboratory of Veterinary Etiological Biology, National Foot-and-mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China. Electronic address: .
Zhao X; Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agriculture Sciences, Beijing 100081, China. Electronic address: .
Guo H; State Key Laboratory of Veterinary Etiological Biology, National Foot-and-mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
Ran X; College of Animal Science and Technology, Hainan University, Hainan Key Lab of Tropical Animal Reproduction and Breeding and Epidemic Disease Research, Haidian Island, Haikou 570228, China.
Wen X; College of Animal Science and Technology, Hainan University, Hainan Key Lab of Tropical Animal Reproduction and Breeding and Epidemic Disease Research, Haidian Island, Haikou 570228, China. Electronic address: .
Sun S; State Key Laboratory of Veterinary Etiological Biology, National Foot-and-mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China. Electronic address: .
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Źródło :
Research in veterinary science [Res Vet Sci] 2021 May; Vol. 136, pp. 89-96. Date of Electronic Publication: 2021 Feb 10.
Typ publikacji :
Journal Article
MeSH Terms :
Immunogenicity, Vaccine*
Nanoparticles*/administration & dosage
Foot-and-Mouth Disease Virus/*immunology
Polylactic Acid-Polyglycolic Acid Copolymer/*immunology
Vaccines, DNA/*immunology
Viral Vaccines/*immunology
Animals ; Foot-and-Mouth Disease/immunology ; Foot-and-Mouth Disease/prevention & control ; Granulocyte-Macrophage Colony-Stimulating Factor/immunology ; Guinea Pigs ; Interleukin-18/immunology ; Interleukin-2/immunology ; Polylactic Acid-Polyglycolic Acid Copolymer/administration & dosage ; Serogroup
Czasopismo naukowe
Tytuł :
Multiple-Coated PLGA Nanoparticles Loading Triptolide Attenuate Injury of a Cellular Model of Alzheimer's Disease.
Autorzy :
Jia L; Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.; Shanxi Provincial People's Hospital, Taiyuan, Shanxi, China.
Nie XQ; Shanxi Provincial People's Hospital, Taiyuan, Shanxi, China.
Ji HM; Shanxi Provincial People's Hospital, Taiyuan, Shanxi, China.
Yuan ZX; College of Pharmacy, Southwest Minzu University, Chengdu, Sichuan, China.
Li RS; Shanxi Provincial People's Hospital, Taiyuan, Shanxi, China.
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Źródło :
BioMed research international [Biomed Res Int] 2021 Feb 25; Vol. 2021, pp. 8825640. Date of Electronic Publication: 2021 Feb 25 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease*/drug therapy
Alzheimer Disease*/metabolism
Alzheimer Disease*/pathology
Coated Materials, Biocompatible*/chemistry
Coated Materials, Biocompatible*/pharmacokinetics
Coated Materials, Biocompatible*/pharmacology
Diterpenes*/chemistry
Diterpenes*/pharmacokinetics
Diterpenes*/pharmacology
Drug Carriers*/chemistry
Drug Carriers*/pharmacokinetics
Drug Carriers*/pharmacology
Models, Neurological*
Nanoparticles*/chemistry
Nanoparticles*/therapeutic use
Phenanthrenes*/chemistry
Phenanthrenes*/pharmacokinetics
Phenanthrenes*/pharmacology
Polylactic Acid-Polyglycolic Acid Copolymer*/chemistry
Polylactic Acid-Polyglycolic Acid Copolymer*/pharmacokinetics
Polylactic Acid-Polyglycolic Acid Copolymer*/pharmacology
Animals ; Caco-2 Cells ; Epoxy Compounds/chemistry ; Epoxy Compounds/pharmacokinetics ; Epoxy Compounds/pharmacology ; Humans ; PC12 Cells ; Rats
Czasopismo naukowe
Tytuł :
Oxyresveratrol Inhibits R848-Induced Pro-Inflammatory Mediators Release by Human Dendritic Cells Even When Embedded in PLGA Nanoparticles.
Autorzy :
Gaglio SC; Department of Biotechnology, University of Verona, Strada Le Grazie 15, 37134 Verona, Italy.
Donini M; Department of Medicine, Section of General Pathology, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy.
Denbaes PE; Department of Biotechnology, University of Verona, Strada Le Grazie 15, 37134 Verona, Italy.
Dusi S; Department of Medicine, Section of General Pathology, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy.
Perduca M; Department of Biotechnology, University of Verona, Strada Le Grazie 15, 37134 Verona, Italy.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Apr 07; Vol. 26 (8). Date of Electronic Publication: 2021 Apr 07.
Typ publikacji :
Journal Article
MeSH Terms :
Polylactic Acid-Polyglycolic Acid Copolymer*/chemistry
Anti-Inflammatory Agents/*administration & dosage
Dendritic Cells/*drug effects
Dendritic Cells/*metabolism
Imidazoles/*adverse effects
Inflammation Mediators/*metabolism
Plant Extracts/*administration & dosage
Stilbenes/*administration & dosage
Anti-Inflammatory Agents/chemistry ; Cytokines/metabolism ; Dendritic Cells/immunology ; Drug Carriers/chemistry ; Drug Delivery Systems ; Drug Synergism ; Humans ; Nanoparticles/chemistry ; Plant Extracts/chemistry ; Stilbenes/chemistry
Czasopismo naukowe
Tytuł :
Biodegradable Nanoparticles-Loaded PLGA Microcapsule for the Enhanced Encapsulation Efficiency and Controlled Release of Hydrophilic Drug.
Autorzy :
Ryu S; Department of Bio-Health Convergence, Kangwon National University, Chuncheon 24341, Korea.
Park S; Department of Herbal Medicine Resource, Kangwon National University, 346 Hwangjo-gil, Dogye-eup, Samcheok-si 25949, Gangwon-do, Korea.
Lee HY; Department of Herbal Medicine Resource, Kangwon National University, 346 Hwangjo-gil, Dogye-eup, Samcheok-si 25949, Gangwon-do, Korea.
Lee H; Department of Herbal Medicine Resource, Kangwon National University, 346 Hwangjo-gil, Dogye-eup, Samcheok-si 25949, Gangwon-do, Korea.
Cho CW; Institute of Drug Research and Development, College of Pharmacy, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, Chungcheong, Korea.
Baek JS; Department of Bio-Health Convergence, Kangwon National University, Chuncheon 24341, Korea.; Department of Herbal Medicine Resource, Kangwon National University, 346 Hwangjo-gil, Dogye-eup, Samcheok-si 25949, Gangwon-do, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 10; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 10.
Typ publikacji :
Journal Article
MeSH Terms :
Delayed-Action Preparations/*pharmacokinetics
Nanoparticles/*chemistry
Pharmaceutical Preparations/*metabolism
Polylactic Acid-Polyglycolic Acid Copolymer/*pharmacokinetics
Alginates/chemistry ; Biodegradation, Environmental ; Capsules ; Chitosan/chemistry ; Delayed-Action Preparations/chemistry ; Drug Carriers ; Drug Liberation ; Hydrophobic and Hydrophilic Interactions ; Microscopy, Electron, Scanning ; Microspheres ; Nanoparticles/ultrastructure ; Particle Size ; Pharmaceutical Preparations/chemistry ; Polylactic Acid-Polyglycolic Acid Copolymer/chemistry
Czasopismo naukowe
Tytuł :
Monovalent antibody-conjugated lipid-polymer nanohybrids for active targeting to desmoglein 3 of keratinocytes to attenuate psoriasiform inflammation.
Autorzy :
Lin ZC; Graduate Institute of Biomedical Sciences, Chang Gung University, Kweishan, Taoyuan, Taiwan.
Hwang TL; Graduate Institute of Natural Products, Chang Gung University, Kweishan, Taoyuan, Taiwan.; Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Kweishan, Taoyuan, Taiwan.; Research Center for Food and Cosmetic Safety and Research Center for Chinese Herbal Medicine, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan.; Department of Chemical Engineering, Ming Chi University of Technology, New Taipei City, Taiwan.; Department of Anesthesiology, Chang Gung Memorial Hospital, Kweishan, Taoyuan, Taiwan.
Huang TH; Research Center for Food and Cosmetic Safety and Research Center for Chinese Herbal Medicine, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan.; Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Keelung, Taiwan.; School of Traditional Chinese Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan.; School of Nursing, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.
Tahara K; Laboratory of Pharmaceutical Engineering, Gifu Pharmaceutical University, Gifu, Japan.
Trousil J; Institute of Macromolecular Chemistry, Czech Academy of Sciences, Prague, Czech Republic.
Fang JY; Graduate Institute of Natural Products, Chang Gung University, Kweishan, Taoyuan, Taiwan.; Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Kweishan, Taoyuan, Taiwan.; Research Center for Food and Cosmetic Safety and Research Center for Chinese Herbal Medicine, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan.; Department of Anesthesiology, Chang Gung Memorial Hospital, Kweishan, Taoyuan, Taiwan.
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Źródło :
Theranostics [Theranostics] 2021 Mar 04; Vol. 11 (10), pp. 4567-4584. Date of Electronic Publication: 2021 Mar 04 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Nanoparticles*
Phospholipids*
Polylactic Acid-Polyglycolic Acid Copolymer*
Boron Compounds/*administration & dosage
Bridged Bicyclo Compounds, Heterocyclic/*administration & dosage
Immunoconjugates/*pharmacology
Keratinocytes/*drug effects
Phosphodiesterase 4 Inhibitors/*administration & dosage
Psoriasis/*immunology
Animals ; Antibodies/immunology ; Boron Compounds/pharmacology ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Chemokine CXCL1/drug effects ; Chemokine CXCL1/immunology ; Chemokine CXCL2/drug effects ; Chemokine CXCL2/immunology ; Chemotaxis/drug effects ; Desmoglein 3/immunology ; Disease Models, Animal ; Drug Carriers ; Drug Delivery Systems ; Epidermis ; HaCaT Cells ; Hair Follicle ; Humans ; Inflammation ; Keratinocytes/immunology ; Lysosomes/metabolism ; Lysosomes/ultrastructure ; Male ; Mice ; Neutrophils/drug effects ; Phosphodiesterase 4 Inhibitors/pharmacology ; Psoriasis/pathology
Czasopismo naukowe
Tytuł :
Preparation of PLGA microspheres loaded with 10-hydroxycamptothecin and arsenic trioxide and their treatment for rabbit hepatocellular carcinoma.
Autorzy :
Wu Y; Department of Interventional Therapy, Shenzhen Second People's Hospital. No. 3002 Sungang West Road, Futian District, Shenzhen, Guangdong 518035, P.R.China.
Du D; Department of Interventional Therapy, Shenzhen Second People's Hospital. No. 3002 Sungang West Road, Futian District, Shenzhen, Guangdong 518035, P.R.China.
Chen J; Department of Interventional Therapy, Shenzhen Second People's Hospital. No. 3002 Sungang West Road, Futian District, Shenzhen, Guangdong 518035, P.R.China.
Liu C; Department of Interventional Therapy, Shenzhen Second People's Hospital. No. 3002 Sungang West Road, Futian District, Shenzhen, Guangdong 518035, P.R.China.
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Źródło :
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia [Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub] 2021 Mar; Vol. 165 (1), pp. 57-63. Date of Electronic Publication: 2020 Jan 06.
Typ publikacji :
Journal Article
MeSH Terms :
Microspheres*
Polylactic Acid-Polyglycolic Acid Copolymer*
Antineoplastic Agents/*administration & dosage
Arsenic Trioxide/*administration & dosage
Camptothecin/*analogs & derivatives
Carcinoma, Hepatocellular/*drug therapy
Liver Neoplasms/*drug therapy
Animals ; Camptothecin/administration & dosage ; Disease Models, Animal ; Rabbits
Czasopismo naukowe
Tytuł :
Mechanistic explanation of the (up to) 3 release phases of PLGA microparticles: Monolithic dispersions studied at lower temperatures.
Autorzy :
Tamani F; Univ. Lille, Inserm, CHU Lille, U1008, F-59000 Lille, France.
Bassand C; Univ. Lille, Inserm, CHU Lille, U1008, F-59000 Lille, France.
Hamoudi MC; Univ. Lille, Inserm, CHU Lille, U1008, F-59000 Lille, France.
Siepmann F; Univ. Lille, Inserm, CHU Lille, U1008, F-59000 Lille, France.
Siepmann J; Univ. Lille, Inserm, CHU Lille, U1008, F-59000 Lille, France. Electronic address: .
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Źródło :
International journal of pharmaceutics [Int J Pharm] 2021 Mar 01; Vol. 596, pp. 120220. Date of Electronic Publication: 2021 Jan 22.
Typ publikacji :
Journal Article
MeSH Terms :
Polylactic Acid-Polyglycolic Acid Copolymer*
Drug Liberation ; Microspheres ; Particle Size ; Temperature
Czasopismo naukowe
Tytuł :
Development and Characterization of PLGA-Based Multistage Delivery System for Enhanced Payload Delivery to Targeted Vascular Endothelium.
Autorzy :
Palma-Chavez JA; Department of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, USA.
Fuentes K; Department of Mechanical Engineering, Texas A&M University, College Station, TX, 77843, USA.
Applegate BE; Prof. B. E. Applegate, Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, 90089, USA.
Jo JA; School of Electrical and Computer Engineering, University of Oklahoma, Norman, OK, 73019, USA.
Charoenphol P; Department of Mechanical Engineering, Texas A&M University, College Station, TX, 77843, USA.
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Źródło :
Macromolecular bioscience [Macromol Biosci] 2021 Mar; Vol. 21 (3), pp. e2000377. Date of Electronic Publication: 2021 Jan 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Drug Delivery Systems*
Endothelium, Vascular/*physiology
Polylactic Acid-Polyglycolic Acid Copolymer/*chemistry
Cell Death ; Cell Survival ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Nanoparticles/chemistry ; Polylactic Acid-Polyglycolic Acid Copolymer/chemical synthesis
Czasopismo naukowe

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