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Wyszukujesz frazę ""PRION diseases"" wg kryterium: Temat


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Tytuł :
Creutzfeldt-Jakob disease as a cause of dementia.
Autorzy :
Nakhleh R; Internal Medicine and Geriatrics, Oregon Health and Science University, Portland, Oregon, USA .
Tessema ST; College of Human Medicine, Michigan State University, East Lansing, Michigan, USA.
Mahgoub A; Internal Medicine, Hurley Medical Center, Flint, Michigan, USA.
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Źródło :
BMJ case reports [BMJ Case Rep] 2021 May 11; Vol. 14 (5). Date of Electronic Publication: 2021 May 11.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Creutzfeldt-Jakob Syndrome*/complications
Creutzfeldt-Jakob Syndrome*/diagnosis
Prion Diseases*
Aged ; Aged, 80 and over ; Humans ; Magnetic Resonance Imaging ; Male
Czasopismo naukowe
Tytuł :
Epilepsy and prion diseases: A narrative review.
Autorzy :
Mbizvo GK; Cognitive Function Clinic, The Walton Centre NHS Foundation Trust, Liverpool, United Kingdom. Electronic address: .
Ziso B; Cognitive Function Clinic, The Walton Centre NHS Foundation Trust, Liverpool, United Kingdom.
Larner AJ; Cognitive Function Clinic, The Walton Centre NHS Foundation Trust, Liverpool, United Kingdom.
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Źródło :
Epilepsy & behavior : E&B [Epilepsy Behav] 2021 Feb; Vol. 115, pp. 107630. Date of Electronic Publication: 2020 Dec 11.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Creutzfeldt-Jakob Syndrome*
Epilepsy*
Prion Diseases*/complications
Prion Diseases*/diagnosis
Prions*/genetics
Humans ; Seizures
Czasopismo naukowe
Tytuł :
Commentary on "Evaluation of New Criterion for Detecting Prion Disease With Diffusion Magnetic Resonance Imaging".
Autorzy :
Melhem ER; Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, 22 S Greene St, N2E23. Baltimore, MD 21201.
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Źródło :
AJR. American journal of roentgenology [AJR Am J Roentgenol] 2021 Feb; Vol. 216 (2), pp. 309. Date of Electronic Publication: 2020 Dec 23.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Prion Diseases*/diagnostic imaging
Diffusion Magnetic Resonance Imaging ; Humans
Czasopismo naukowe
Tytuł :
Prion diseases reported in the "Annual of the Pathological Autopsy Cases in Japan".
Autorzy :
Horimoto Y; Department of Neurology, Nagoya City Rehabilitation Center, Japan. Electronic address: .
Sato C; Department of Neurology, Nagoya City Rehabilitation Center, Japan.
Inagaki A; Department of Neurology, Nagoya City Rehabilitation Center, Japan.
Tajima T; Department of Neurology, Nagoya City Rehabilitation Center, Japan.
Hibino H; Department of Neurology, Nagoya City Rehabilitation Center, Japan.
Kabasawa H; Department of Neurology, Nagoya City Rehabilitation Center, Japan.
Inagaki H; Department of Anatomic Pathology and Molecular Diagnostics, Nagoya City University, Japan.
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Źródło :
Journal of the neurological sciences [J Neurol Sci] 2021 Jan 15; Vol. 420, pp. 117215. Date of Electronic Publication: 2020 Nov 02.
Typ publikacji :
Journal Article
MeSH Terms :
Creutzfeldt-Jakob Syndrome*
Gerstmann-Straussler-Scheinker Disease*
Prion Diseases*/epidemiology
Autopsy ; Humans ; Japan/epidemiology
Czasopismo naukowe
Tytuł :
Short and sweet: How glycans impact prion conversion, cofactor interactions, and cross-species transmission.
Autorzy :
Aguilar-Calvo P; Department of Pathology, University of California, San Diego, La Jolla, California, United States of America.
Callender JA; Department of Pathology, University of California, San Diego, La Jolla, California, United States of America.
Sigurdson CJ; Department of Pathology, University of California, San Diego, La Jolla, California, United States of America.; Department of Medicine, University of California, San Diego, La Jolla, California, United States of America.; Department of Pathology, Microbiology, and Immunology, University of California, Davis, Davis, California, United States of America.
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Źródło :
PLoS pathogens [PLoS Pathog] 2021 Jan 14; Vol. 17 (1), pp. e1009123. Date of Electronic Publication: 2021 Jan 14 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Amyloid/*metabolism
Polysaccharides/*metabolism
PrPC Proteins/*metabolism
Prion Diseases/*transmission
Prions/*metabolism
Amyloid/chemistry ; Animals ; Polysaccharides/chemistry ; Prion Diseases/metabolism ; Prions/chemistry ; Species Specificity
Czasopismo naukowe
Tytuł :
Genetic prion disease: opportunities for early therapeutic intervention with rigorous pre-symptomatic trials.
Autorzy :
Hermann P; National Reference Center for TSE, University Medical Center Göttingen , Göttingen, Germany.; Department of Neurology, University Medical Center Göttingen , Göttingen, Germany.
Koch JC; Department of Neurology, University Medical Center Göttingen , Göttingen, Germany.
Zerr I; National Reference Center for TSE, University Medical Center Göttingen , Göttingen, Germany.; Department of Neurology, University Medical Center Göttingen , Göttingen, Germany.; German Center for Neurodegenerative Diseases (DZNE) , Göttingen, Germany.
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Źródło :
Expert opinion on investigational drugs [Expert Opin Investig Drugs] 2020 Dec; Vol. 29 (12), pp. 1313-1316. Date of Electronic Publication: 2020 Nov 01.
Typ publikacji :
Editorial
MeSH Terms :
Prion Diseases/*genetics
Prion Proteins/*genetics
Animals ; Humans ; Mutation ; Prion Diseases/drug therapy ; Research Design
Opinia redakcyjna
Tytuł :
A seven-residue deletion in PrP leads to generation of a spontaneous prion formed from C-terminal C1 fragment of PrP.
Autorzy :
Munoz-Montesino C; Université Paris-Saclay, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Université de Versailles Saint-Quentin-en-Yvelines, Virologie et Immunologie Moléculaires, Jouy-en-Josas, France.
Larkem D; Université Paris-Saclay, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Université de Versailles Saint-Quentin-en-Yvelines, Virologie et Immunologie Moléculaires, Jouy-en-Josas, France.
Barbereau C; Université Paris-Saclay, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Université de Versailles Saint-Quentin-en-Yvelines, Virologie et Immunologie Moléculaires, Jouy-en-Josas, France.
Igel-Egalon A; Université Paris-Saclay, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Université de Versailles Saint-Quentin-en-Yvelines, Virologie et Immunologie Moléculaires, Jouy-en-Josas, France.
Truchet S; Université Paris-Saclay, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Université de Versailles Saint-Quentin-en-Yvelines, Virologie et Immunologie Moléculaires, Jouy-en-Josas, France.
Jacquet E; Institut de Chimie des Substances Naturelles, CNRS, Université Paris-Saclay, Gif-sur-Yvette, France.
Nhiri N; Institut de Chimie des Substances Naturelles, CNRS, Université Paris-Saclay, Gif-sur-Yvette, France.
Moudjou M; Université Paris-Saclay, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Université de Versailles Saint-Quentin-en-Yvelines, Virologie et Immunologie Moléculaires, Jouy-en-Josas, France.
Sizun C; Institut de Chimie des Substances Naturelles, CNRS, Université Paris-Saclay, Gif-sur-Yvette, France.
Rezaei H; Université Paris-Saclay, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Université de Versailles Saint-Quentin-en-Yvelines, Virologie et Immunologie Moléculaires, Jouy-en-Josas, France.
Béringue V; Université Paris-Saclay, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Université de Versailles Saint-Quentin-en-Yvelines, Virologie et Immunologie Moléculaires, Jouy-en-Josas, France.
Dron M; Université Paris-Saclay, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Université de Versailles Saint-Quentin-en-Yvelines, Virologie et Immunologie Moléculaires, Jouy-en-Josas, France .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Oct 09; Vol. 295 (41), pp. 14025-14039. Date of Electronic Publication: 2020 Aug 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amino Acid Sequence*
PrPSc Proteins*/chemistry
PrPSc Proteins*/genetics
PrPSc Proteins*/metabolism
Prion Diseases*/genetics
Prion Diseases*/metabolism
Prion Diseases*/pathology
Protein Aggregation, Pathological*/genetics
Protein Aggregation, Pathological*/metabolism
Protein Aggregation, Pathological*/pathology
Sequence Deletion*
Animals ; Cell Line ; Humans ; Protein Conformation, alpha-Helical ; Protein Domains ; Rabbits ; Sheep ; Solubility
Czasopismo naukowe
Tytuł :
Bovine adapted transmissible mink encephalopathy is similar to L-BSE after passage through sheep with the VRQ/VRQ genotype but not VRQ/ARQ.
Autorzy :
Cassmann E; Virus and Prion Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, 1920 Dayton Avenue, P.O. Box 70, Ames, IA, 50010, USA.; Oak Ridge Institute for Science and Education (ORISE) through an interagency agreement between the U.S. Department of Energy (DOE) and the U.S. Department of Agriculture (USDA). ORISE is managed by ORAU under DOE contract number DE-SC0014664, Oak Ridge, USA.
Moore SJ; Virus and Prion Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, 1920 Dayton Avenue, P.O. Box 70, Ames, IA, 50010, USA.; Oak Ridge Institute for Science and Education (ORISE) through an interagency agreement between the U.S. Department of Energy (DOE) and the U.S. Department of Agriculture (USDA). ORISE is managed by ORAU under DOE contract number DE-SC0014664, Oak Ridge, USA.
Kokemuller R; Virus and Prion Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, 1920 Dayton Avenue, P.O. Box 70, Ames, IA, 50010, USA.
Balkema-Buschmann A; Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, -Isle of Riems, Greifswald, Germany.
Groschup M; Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, -Isle of Riems, Greifswald, Germany.
Nicholson E; Virus and Prion Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, 1920 Dayton Avenue, P.O. Box 70, Ames, IA, 50010, USA.
Greenlee J; Virus and Prion Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, 1920 Dayton Avenue, P.O. Box 70, Ames, IA, 50010, USA. .
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Źródło :
BMC veterinary research [BMC Vet Res] 2020 Oct 08; Vol. 16 (1), pp. 383. Date of Electronic Publication: 2020 Oct 08.
Typ publikacji :
Journal Article
MeSH Terms :
Prion Diseases/*genetics
Prion Diseases/*transmission
Prion Proteins/*genetics
Prions/*genetics
Animals ; Brain/pathology ; Cattle ; Encephalopathy, Bovine Spongiform/genetics ; Encephalopathy, Bovine Spongiform/pathology ; Encephalopathy, Bovine Spongiform/transmission ; Mice, Transgenic ; PrPC Proteins/genetics ; Prion Diseases/pathology
Czasopismo naukowe
Tytuł :
The Effects of Immune System Modulation on Prion Disease Susceptibility and Pathogenesis.
Autorzy :
Mabbott NA; The Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.
Bradford BM; The Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.
Pal R; The Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.
Young R; The Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.
Donaldson DS; The Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Oct 02; Vol. 21 (19). Date of Electronic Publication: 2020 Oct 02.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Brain/*immunology
Immune System/*immunology
Prion Diseases/*immunology
Prions/*immunology
Aging/immunology ; Aging/pathology ; Brain/metabolism ; Disease Susceptibility ; Humans ; Immune System/metabolism ; Immunomodulation/genetics ; Prion Diseases/genetics ; Prion Diseases/pathology ; Prions/genetics
Czasopismo naukowe
Tytuł :
The Role of Vesicle Trafficking Defects in the Pathogenesis of Prion and Prion-Like Disorders.
Autorzy :
Cherry P; Calgary Prion Research Unit, Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB T2N 4Z6, Canada.; Hotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4Z6, Canada.
Gilch S; Calgary Prion Research Unit, Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB T2N 4Z6, Canada.; Hotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4Z6, Canada.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Sep 23; Vol. 21 (19). Date of Electronic Publication: 2020 Sep 23.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Extracellular Vesicles/*metabolism
PrPSc Proteins/*metabolism
Prion Diseases/*metabolism
Proteostasis Deficiencies/*metabolism
Animals ; Biological Transport, Active ; Extracellular Vesicles/pathology ; Humans ; Prion Diseases/pathology ; Proteostasis Deficiencies/pathology
Czasopismo naukowe
Tytuł :
Ribosomal profiling during prion disease uncovers progressive translational derangement in glia but not in neurons.
Autorzy :
Scheckel C; Institute of Neuropathology, University of Zurich, Zurich, Switzerland.
Imeri M; Institute of Neuropathology, University of Zurich, Zurich, Switzerland.
Schwarz P; Institute of Neuropathology, University of Zurich, Zurich, Switzerland.
Aguzzi A; Institute of Neuropathology, University of Zurich, Zurich, Switzerland.
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Źródło :
ELife [Elife] 2020 Sep 22; Vol. 9. Date of Electronic Publication: 2020 Sep 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Neuroglia*/metabolism
Neuroglia*/pathology
Prion Diseases*/metabolism
Prion Diseases*/pathology
Ribosomal Proteins*/analysis
Ribosomal Proteins*/chemistry
Ribosomal Proteins*/genetics
Ribosomal Proteins*/metabolism
Ribosomes*/chemistry
Ribosomes*/metabolism
Neurons/*metabolism
Animals ; Green Fluorescent Proteins ; Mice ; Mice, Transgenic ; Recombinant Fusion Proteins
Czasopismo naukowe
Tytuł :
Highly infectious prions are not directly neurotoxic.
Autorzy :
Benilova I; Medical Research Council Prion Unit at University College London (UCL), UCL Institute of Prion Diseases, London W1W 7FF, United Kingdom.
Reilly M; Medical Research Council Prion Unit at University College London (UCL), UCL Institute of Prion Diseases, London W1W 7FF, United Kingdom.
Terry C; Medical Research Council Prion Unit at University College London (UCL), UCL Institute of Prion Diseases, London W1W 7FF, United Kingdom.
Wenborn A; Medical Research Council Prion Unit at University College London (UCL), UCL Institute of Prion Diseases, London W1W 7FF, United Kingdom.
Schmidt C; Medical Research Council Prion Unit at University College London (UCL), UCL Institute of Prion Diseases, London W1W 7FF, United Kingdom.
Marinho AT; Medical Research Council Prion Unit at University College London (UCL), UCL Institute of Prion Diseases, London W1W 7FF, United Kingdom.
Risse E; Medical Research Council Prion Unit at University College London (UCL), UCL Institute of Prion Diseases, London W1W 7FF, United Kingdom.
Al-Doujaily H; Medical Research Council Prion Unit at University College London (UCL), UCL Institute of Prion Diseases, London W1W 7FF, United Kingdom.
Wiggins De Oliveira M; Medical Research Council Prion Unit at University College London (UCL), UCL Institute of Prion Diseases, London W1W 7FF, United Kingdom.
Sandberg MK; Medical Research Council Prion Unit at University College London (UCL), UCL Institute of Prion Diseases, London W1W 7FF, United Kingdom.
Wadsworth JDF; Medical Research Council Prion Unit at University College London (UCL), UCL Institute of Prion Diseases, London W1W 7FF, United Kingdom.
Jat PS; Medical Research Council Prion Unit at University College London (UCL), UCL Institute of Prion Diseases, London W1W 7FF, United Kingdom.
Collinge J; Medical Research Council Prion Unit at University College London (UCL), UCL Institute of Prion Diseases, London W1W 7FF, United Kingdom jc@prion.ucl.ac.uk.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Sep 22; Vol. 117 (38), pp. 23815-23822. Date of Electronic Publication: 2020 Sep 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Neurotoxins*/isolation & purification
Neurotoxins*/metabolism
Neurotoxins*/toxicity
Prion Diseases*/metabolism
Prion Diseases*/physiopathology
Prions*/isolation & purification
Prions*/metabolism
Prions*/pathogenicity
Animals ; Brain/cytology ; Brain/drug effects ; Brain Chemistry ; Disease Models, Animal ; Mice ; Neurons/drug effects
Czasopismo naukowe
Tytuł :
Identification of a homology-independent linchpin domain controlling mouse and bank vole prion protein conversion.
Autorzy :
Burke CM; Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America.
Mark KMK; Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America.
Walsh DJ; Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America.
Noble GP; Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America.
Steele AD; Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America.
Diack AB; The Roslin Institute and R(D)SVS, University of Edinburgh, Easter Bush, Scotland, United Kingdom.
Manson JC; The Roslin Institute and R(D)SVS, University of Edinburgh, Easter Bush, Scotland, United Kingdom.
Watts JC; Tanz Centre for Research in Neurodegenerative Diseases, Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.
Supattapone S; Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America.; Department of Medicine, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Sep 08; Vol. 16 (9), pp. e1008875. Date of Electronic Publication: 2020 Sep 08 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Brain/*metabolism
PrPC Proteins/*metabolism
PrPSc Proteins/*metabolism
Prion Diseases/*metabolism
Animals ; Arvicolinae ; Brain/pathology ; Cricetinae ; Mesocricetus ; Mice ; Mice, Transgenic ; PrPC Proteins/genetics ; PrPSc Proteins/genetics ; Prion Diseases/genetics ; Prion Diseases/pathology ; Protein Domains
Czasopismo naukowe
Tytuł :
Marked abnormalities of plasma protein biomarkers in Creutzfeldt-Jakob disease (CJD).
Autorzy :
Mead S; MRC Prion Unit at UCL, UCL Institute of Neurology, London, London, UK s.mead@prion.ucl.ac.uk.
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Źródło :
Journal of neurology, neurosurgery, and psychiatry [J Neurol Neurosurg Psychiatry] 2020 Nov; Vol. 91 (11), pp. 1137. Date of Electronic Publication: 2020 Sep 14.
Typ publikacji :
Editorial; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Creutzfeldt-Jakob Syndrome*/diagnosis
Prion Diseases*
Biomarkers ; Blood Proteins ; Early Diagnosis ; Humans ; Plasma
Raport
Tytuł :
Shifts and drifts in prion science.
Autorzy :
Aguzzi A; Institute of Neuropathology, University of Zürich, Rümistrasse 100, CH-8091 Zürich, Switzerland. .
De Cecco E; Institute of Neuropathology, University of Zürich, Rümistrasse 100, CH-8091 Zürich, Switzerland.
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Źródło :
Science (New York, N.Y.) [Science] 2020 Oct 02; Vol. 370 (6512), pp. 32-34.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Aggregates*
PrPSc Proteins/*biosynthesis
PrPSc Proteins/*chemistry
Prion Diseases/*transmission
Animals ; Cricetinae ; Humans ; Mice ; PrPSc Proteins/genetics ; Prion Diseases/metabolism ; Protein Conformation ; Protein Stability
Czasopismo naukowe
Tytuł :
Multimodal small-molecule screening for human prion protein binders.
Autorzy :
Reidenbach AG; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Mesleh MF; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Casalena D; Facilitated Access to Screening Technologies (FAST) Lab, Novartis Institutes for Biomedical Research (NIBR), Cambridge, Massachusetts, USA.
Vallabh SM; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA; Prion Alliance, Cambridge, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA.
Dahlin JL; Harvard Medical School, Boston, Massachusetts, USA; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Leed AJ; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Chan AI; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Usanov DL; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Yehl JB; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Lemke CT; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Campbell AJ; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Shah RN; Undergraduate Research Opportunities Program (UROP), Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Shrestha OK; Facilitated Access to Screening Technologies (FAST) Lab, Novartis Institutes for Biomedical Research (NIBR), Cambridge, Massachusetts, USA.
Sacher JR; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Rangel VL; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Moroco JA; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Sathappa M; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Nonato MC; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Nguyen KT; Artificial Intelligence Molecular Screen (AIMS) Awards Program, Atomwise, San Francisco, California, USA.
Wright SK; Facilitated Access to Screening Technologies (FAST) Lab, Novartis Institutes for Biomedical Research (NIBR), Cambridge, Massachusetts, USA.
Liu DR; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA; Howard Hughes Medical Institute, Chevy Chase, Maryland, USA; Department of Chemistry & Chemical Biology, Harvard University, Cambridge, Massachusetts, USA.
Wagner FF; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Kaushik VK; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Auld DS; Facilitated Access to Screening Technologies (FAST) Lab, Novartis Institutes for Biomedical Research (NIBR), Cambridge, Massachusetts, USA.
Schreiber SL; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA; Department of Chemistry & Chemical Biology, Harvard University, Cambridge, Massachusetts, USA.
Minikel EV; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA; Prion Alliance, Cambridge, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Sep 25; Vol. 295 (39), pp. 13516-13531. Date of Electronic Publication: 2020 Jul 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Benzimidazoles/*pharmacology
Prion Diseases/*drug therapy
Prion Proteins/*antagonists & inhibitors
Small Molecule Libraries/*pharmacology
Benzimidazoles/chemistry ; Drug Discovery ; Drug Evaluation, Preclinical ; Humans ; Magnetic Resonance Spectroscopy ; Prion Diseases/metabolism ; Prion Proteins/metabolism ; Small Molecule Libraries/chemistry
Czasopismo naukowe
Tytuł :
Using NMR spectroscopy to investigate the role played by copper in prion diseases.
Autorzy :
Alsiary RA; King Abdullah International Medical Research Center (KAIMRC), Jeddah, Saudi Arabia/King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Jeddah, Saudi Arabia.
Alghrably M; Biological and Environmental Science and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia.
Saoudi A; Oncology, Ministry of National Guard Health Affairs, Jeddah, Saudi Arabia. King Abdullah International Medical Research Center (KAIMRC), Jeddah, Saudi Arabia/King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Jeddah, Saudi Arabia.
Al-Ghamdi S; Oncology, Ministry of National Guard Health Affairs, Jeddah, Saudi Arabia. King Abdullah International Medical Research Center (KAIMRC), Jeddah, Saudi Arabia/King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Jeddah, Saudi Arabia.
Jaremko L; Biological and Environmental Science and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia.
Jaremko M; Biological and Environmental Science and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia. .
Emwas AH; Imaging and Characterization Core Lab, King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia. .
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Źródło :
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2020 Sep; Vol. 41 (9), pp. 2389-2406. Date of Electronic Publication: 2020 Apr 24.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Prion Diseases*
Prions*
Copper ; Humans ; Magnetic Resonance Spectroscopy
Czasopismo naukowe
Tytuł :
POSCAbilities: The Application of the Prion Organotypic Slice Culture Assay to Neurodegenerative Disease Research.
Autorzy :
Pineau H; Centre for Prions and Protein Folding Diseases, University of Alberta, 204 Brain and Aging Research Building, 8710-112 St, Edmonton, AB T6G 2M8, Canada.; Neuroscience and Mental Health Institute, University of Alberta, 2-132 Li Ka Shing, Edmonton, AB T6G 2E1, Canada.; Division of Neurology, Department of Medicine, Faculty of Medicine & Dentistry, University of Alberta, Clinical Sciences Building, 8440-112 St, Edmonton, AB T6G 2B7, Canada.
Sim V; Centre for Prions and Protein Folding Diseases, University of Alberta, 204 Brain and Aging Research Building, 8710-112 St, Edmonton, AB T6G 2M8, Canada.; Neuroscience and Mental Health Institute, University of Alberta, 2-132 Li Ka Shing, Edmonton, AB T6G 2E1, Canada.; Division of Neurology, Department of Medicine, Faculty of Medicine & Dentistry, University of Alberta, Clinical Sciences Building, 8440-112 St, Edmonton, AB T6G 2B7, Canada.
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Źródło :
Biomolecules [Biomolecules] 2020 Jul 20; Vol. 10 (7). Date of Electronic Publication: 2020 Jul 20.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Neurodegenerative Diseases/*pathology
Organ Culture Techniques/*methods
Prion Diseases/*pathology
Prions/*analysis
Animals ; Biomedical Research/methods ; Brain/drug effects ; Brain/metabolism ; Brain/pathology ; Drug Evaluation, Preclinical/methods ; Humans ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/metabolism ; Prion Diseases/drug therapy ; Prion Diseases/metabolism ; Prions/metabolism ; Protein Aggregation, Pathological/drug therapy ; Protein Aggregation, Pathological/metabolism ; Protein Aggregation, Pathological/pathology
Czasopismo naukowe
Tytuł :
Genome-wide transcriptomics identifies an early preclinical signature of prion infection.
Autorzy :
Sorce S; Institute of Neuropathology, University of Zurich, Zurich, Switzerland.
Nuvolone M; Institute of Neuropathology, University of Zurich, Zurich, Switzerland.; Amyloidosis Research and Treatment Center, Foundation Scientific Institute Policlinico San Matteo, Department of Molecular Medicine, University of Pavia, Pavia, Italy.
Russo G; Functional Genomics Center Zurich, ETH/University of Zurich, Zurich, Switzerland.
Chincisan A; Institute of Neuropathology, University of Zurich, Zurich, Switzerland.
Heinzer D; Institute of Neuropathology, University of Zurich, Zurich, Switzerland.
Avar M; Institute of Neuropathology, University of Zurich, Zurich, Switzerland.
Pfammatter M; Institute of Neuropathology, University of Zurich, Zurich, Switzerland.
Schwarz P; Institute of Neuropathology, University of Zurich, Zurich, Switzerland.
Delic M; Institute of Neuropathology, University of Zurich, Zurich, Switzerland.
Müller M; Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.
Hornemann S; Institute of Neuropathology, University of Zurich, Zurich, Switzerland.
Sanoudou D; Clinical Genomics and Pharmacogenomics Unit, 4th Department of Internal Medicine, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Scheckel C; Institute of Neuropathology, University of Zurich, Zurich, Switzerland.
Aguzzi A; Institute of Neuropathology, University of Zurich, Zurich, Switzerland.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Jun 29; Vol. 16 (6), pp. e1008653. Date of Electronic Publication: 2020 Jun 29 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genome-Wide Association Study*
Prion Diseases*/genetics
Prion Diseases*/metabolism
RNA, Messenger*/genetics
RNA, Messenger*/metabolism
Transcriptome*
Microglia/*metabolism
Neurons/*metabolism
Animals ; Male ; Mice ; Mice, Knockout
Czasopismo naukowe
Tytuł :
Cerebrospinal fluid and plasma biomarkers in individuals at risk for genetic prion disease.
Autorzy :
Vallabh SM; Henry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, 02114, USA. .; Department of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA. .; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, 415 Main St., Cambridge, MA, 02142, USA. .; Prion Alliance, Cambridge, MA, 02139, USA. .
Minikel EV; Henry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, 02114, USA.; Department of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, 415 Main St., Cambridge, MA, 02142, USA.; Prion Alliance, Cambridge, MA, 02139, USA.
Williams VJ; Department of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA.
Carlyle BC; Department of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA.
McManus AJ; Department of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA.
Wennick CD; Department of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA.
Bolling A; Department of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA.
Trombetta BA; Department of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA.
Urick D; Department of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA.
Nobuhara CK; Department of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA.
Gerber J; Department of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA.
Duddy H; Department of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA.
Lachmann I; AJ Roboscreen GmbH, 04129, Leipzig, Germany.
Stehmann C; Australian National CJD Registry, University of Melbourne, Parkville, 3010, Australia.
Collins SJ; Australian National CJD Registry, University of Melbourne, Parkville, 3010, Australia.
Blennow K; Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, S-431 80, Mölndal, Sweden.
Zetterberg H; Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, S-431 80, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, S-431 80, Mölndal, Sweden.; UK Dementia Research Institute, University College London, London, WC1N 3BG, UK.; Department of Molecular Neuroscience, UCL Institute of Neurology, London, WC1N 3BG, UK.
Arnold SE; Henry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, 02114, USA. .; Department of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA. .
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Źródło :
BMC medicine [BMC Med] 2020 Jun 18; Vol. 18 (1), pp. 140. Date of Electronic Publication: 2020 Jun 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Biomarkers/*metabolism
Neurodegenerative Diseases/*diagnosis
Prion Diseases/*diagnosis
Adult ; Cohort Studies ; Female ; Humans ; Longitudinal Studies ; Male ; Neurodegenerative Diseases/blood ; Neurodegenerative Diseases/cerebrospinal fluid ; Prion Diseases/blood ; Prion Diseases/cerebrospinal fluid ; Reproducibility of Results ; Risk Factors
Czasopismo naukowe

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