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Tytuł :
trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo.
Autorzy :
Aron ZD; Microbiotix, Inc. One Innovation Dr., Worcester, MA, USA.
Mehrani A; Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL, USA.
Hoffer ED; Department of Biochemistry and Emory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, GA, USA.
Connolly KL; Department of Microbiology and Immunology, Uniformed Services University, Bethesda, MD, USA.
Srinivas P; Department of Biochemistry and Emory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, GA, USA.; Molecular & Systems Pharmacology Graduate Program, Emory University, Atlanta, GA, USA.
Torhan MC; Microbiotix, Inc. One Innovation Dr., Worcester, MA, USA.
Alumasa JN; Department of Biochemistry & Molecular Biology, Penn State University, University Park, PA, USA.
Cabrera M; Department of Biochemistry & Molecular Biology, Penn State University, University Park, PA, USA.
Hosangadi D; Department of Biochemistry & Molecular Biology, Penn State University, University Park, PA, USA.
Barbor JS; Microbiotix, Inc. One Innovation Dr., Worcester, MA, USA.
Cardinale SC; Microbiotix, Inc. One Innovation Dr., Worcester, MA, USA.
Kwasny SM; Microbiotix, Inc. One Innovation Dr., Worcester, MA, USA.
Morin LR; Microbiotix, Inc. One Innovation Dr., Worcester, MA, USA.
Butler MM; Microbiotix, Inc. One Innovation Dr., Worcester, MA, USA.
Opperman TJ; Microbiotix, Inc. One Innovation Dr., Worcester, MA, USA.
Bowlin TL; Microbiotix, Inc. One Innovation Dr., Worcester, MA, USA.
Jerse A; Department of Microbiology and Immunology, Uniformed Services University, Bethesda, MD, USA.
Stagg SM; Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL, USA.; Institute of Molecular Biophysics, Florida State University, Tallahassee, FL, USA.
Dunham CM; Department of Biochemistry and Emory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, GA, USA. .
Keiler KC; Department of Biochemistry & Molecular Biology, Penn State University, University Park, PA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Mar 19; Vol. 12 (1), pp. 1799. Date of Electronic Publication: 2021 Mar 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Neisseria gonorrhoeae/*drug effects
Protein Biosynthesis/*drug effects
Protein Synthesis Inhibitors/*pharmacology
Ribosomes/*drug effects
Animals ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Binding Sites/genetics ; Caco-2 Cells ; Female ; Gonorrhea/microbiology ; Gonorrhea/prevention & control ; Humans ; Mice ; Neisseria gonorrhoeae/genetics ; Protein Biosynthesis/genetics ; Protein Synthesis Inhibitors/chemistry ; RNA, Bacterial/genetics ; RNA, Bacterial/metabolism ; Ribosomal Proteins/genetics ; Ribosomal Proteins/metabolism ; Ribosomes/genetics ; Ribosomes/metabolism
Czasopismo naukowe
Tytuł :
The efficacy and safety of a homoharringtonine-based protocol for children with acute myeloid leukemia: A retrospective study in China.
Autorzy :
Tang Y; Department of Hematology/Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Key Lab of Pediatric Hematology & Oncology of China Ministry of Health, Shanghai, China.
Luo C; Department of Hematology/Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Key Lab of Pediatric Hematology & Oncology of China Ministry of Health, Shanghai, China.
Shen S; Department of Hematology/Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Key Lab of Pediatric Hematology & Oncology of China Ministry of Health, Shanghai, China.
Xue H; Department of Hematology/Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Key Lab of Pediatric Hematology & Oncology of China Ministry of Health, Shanghai, China.
Pan C; Department of Hematology/Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Key Lab of Pediatric Hematology & Oncology of China Ministry of Health, Shanghai, China.
Hu W; Department of Hematology/Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Key Lab of Pediatric Hematology & Oncology of China Ministry of Health, Shanghai, China.
Chen X; Department of Hematology/Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Key Lab of Pediatric Hematology & Oncology of China Ministry of Health, Shanghai, China.
Cai J; Department of Hematology/Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Key Lab of Pediatric Hematology & Oncology of China Ministry of Health, Shanghai, China.
Chen J; Department of Hematology/Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Key Lab of Pediatric Hematology & Oncology of China Ministry of Health, Shanghai, China.
Tang J; Department of Hematology/Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Key Lab of Pediatric Hematology & Oncology of China Ministry of Health, Shanghai, China.
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Źródło :
Pediatric hematology and oncology [Pediatr Hematol Oncol] 2021 Mar; Vol. 38 (2), pp. 97-107. Date of Electronic Publication: 2020 Oct 05.
Typ publikacji :
Journal Article
MeSH Terms :
Homoharringtonine/*therapeutic use
Leukemia, Myeloid, Acute/*drug therapy
Protein Synthesis Inhibitors/*therapeutic use
Adolescent ; Child ; Child, Preschool ; China ; Female ; Homoharringtonine/pharmacology ; Humans ; Infant ; Infant, Newborn ; Male ; Protein Synthesis Inhibitors/pharmacology ; Retrospective Studies
Czasopismo naukowe
Tytuł :
A comparison of endolymphatic shunt surgery and intratympanic gentamicin for meniere's disease.
Autorzy :
Gibson AW; Department of Otolaryngology-Head and Neck Surgery, University of Washington School of Medicine, Seattle, USA.
Moon IJ; Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Golub JS; Department of Otolaryngology-Head and Neck Surgery, Columbia University Vagelos College of Physicians and Surgeons, New York, USA.
Rubinstein JT; Department of Otolaryngology-Head and Neck Surgery, University of Washington School of Medicine, Seattle, USA.
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Źródło :
The Laryngoscope [Laryngoscope] 2020 Oct; Vol. 130 (10), pp. 2455-2460. Date of Electronic Publication: 2019 Dec 06.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Endolymphatic Shunt*
Gentamicins/*therapeutic use
Meniere Disease/*therapy
Protein Synthesis Inhibitors/*therapeutic use
Audiometry, Pure-Tone ; Female ; Gentamicins/administration & dosage ; Humans ; Male ; Middle Aged ; Protein Synthesis Inhibitors/administration & dosage ; Retrospective Studies ; Tympanic Membrane/drug effects
Czasopismo naukowe
Tytuł :
Puromycin reactivity does not accurately localize translation at the subcellular level.
Autorzy :
Enam SU; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, United States.; Howard Hughes Medical Institute, Baltimore, United States.
Zinshteyn B; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, United States.; Howard Hughes Medical Institute, Baltimore, United States.
Goldman DH; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, United States.; Howard Hughes Medical Institute, Baltimore, United States.
Cassani M; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, United States.; Howard Hughes Medical Institute, Baltimore, United States.
Livingston NM; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, United States.
Seydoux G; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, United States.; Howard Hughes Medical Institute, Baltimore, United States.
Green R; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, United States.; Howard Hughes Medical Institute, Baltimore, United States.
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Źródło :
ELife [Elife] 2020 Aug 26; Vol. 9. Date of Electronic Publication: 2020 Aug 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Cell Nucleus*/chemistry
Cell Nucleus*/metabolism
Protein Biosynthesis*/drug effects
Protein Biosynthesis*/physiology
Protein Synthesis Inhibitors*/metabolism
Protein Synthesis Inhibitors*/pharmacology
Puromycin*/metabolism
Puromycin*/pharmacology
Animals ; Caenorhabditis elegans ; Emetine/metabolism ; Emetine/pharmacology ; Peptides/metabolism ; RNA, Transfer/metabolism ; Rabbits ; Ribosomes/metabolism ; Single-Cell Analysis
Czasopismo naukowe
Tytuł :
Elongation inhibitors do not prevent the release of puromycylated nascent polypeptide chains from ribosomes.
Autorzy :
Hobson BD; Department of Systems Biology, Columbia University Irving Medical Center, New York, United States.; Medical Scientist Training Program, Columbia University Irving Medical Center, New York, United States.
Kong L; Department of Systems Biology, Columbia University Irving Medical Center, New York, United States.
Hartwick EW; Department of Chemistry, Columbia University, New York, United States.
Gonzalez RL; Department of Chemistry, Columbia University, New York, United States.
Sims PA; Department of Systems Biology, Columbia University Irving Medical Center, New York, United States.; Department of Biochemistry & Molecular Biophysics, Columbia University Irving Medical Center, New York, United States.; Sulzberger Columbia Genome Center, Columbia University Irving Medical Center, New York, United States.
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Źródło :
ELife [Elife] 2020 Aug 26; Vol. 9. Date of Electronic Publication: 2020 Aug 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Synthesis Inhibitors*/metabolism
Protein Synthesis Inhibitors*/pharmacology
Puromycin*/metabolism
Puromycin*/pharmacology
Ribosomes*/drug effects
Ribosomes*/metabolism
Peptide Chain Elongation, Translational/*drug effects
Animals ; Cell Line, Tumor ; Mice ; Proteins/chemistry ; Proteins/metabolism ; RNA, Messenger/chemistry ; RNA, Messenger/metabolism ; RNA, Transfer, Amino Acyl/chemistry ; RNA, Transfer, Amino Acyl/metabolism
Czasopismo naukowe
Tytuł :
Social Fear Memory Requires Two Stages of Protein Synthesis in Mice.
Autorzy :
Kornhuber J; Department of Psychiatry and Psychotherapy, Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Zoicas I; Department of Psychiatry and Psychotherapy, Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.; Department of Behavioural and Molecular Neurobiology, University of Regensburg, 93040 Regensburg, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Aug 02; Vol. 21 (15). Date of Electronic Publication: 2020 Aug 02.
Typ publikacji :
Journal Article
MeSH Terms :
Anisomycin/*pharmacology
Fear/*drug effects
Memory/*drug effects
Protein Biosynthesis/*drug effects
Protein Synthesis Inhibitors/*pharmacology
Animals ; Anisomycin/administration & dosage ; Conditioning, Classical/drug effects ; Male ; Mice ; Protein Synthesis Inhibitors/administration & dosage ; Time Factors
Czasopismo naukowe
Tytuł :
The prohibitin-binding compound fluorizoline affects multiple components of the translational machinery and inhibits protein synthesis.
Autorzy :
Jin X; Lifelong Health Theme, South Australian Health & Medical Research Institute, Adelaide, Australia.; Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology and School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
Xie J; Lifelong Health Theme, South Australian Health & Medical Research Institute, Adelaide, Australia.
Zabolocki M; Lifelong Health Theme, South Australian Health & Medical Research Institute, Adelaide, Australia.; Laboratory for Human Neurophysiology and Genetics, College of Medicine and Public Health, Flinders University, Adelaide, Australia.
Wang X; Lifelong Health Theme, South Australian Health & Medical Research Institute, Adelaide, Australia.; School of Biological Sciences, University of Adelaide, Adelaide, Australia.
Jiang T; Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology and School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
Wang D; Sino-French Joint Lab of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, Tianjin University of Science and Technology, Tianjin, China.
Désaubry L; Sino-French Joint Lab of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, Tianjin University of Science and Technology, Tianjin, China.; Laboratory of Medicinal Chemistry and Cardio-oncology, CNRS, Strasbourg, France.
Bardy C; Lifelong Health Theme, South Australian Health & Medical Research Institute, Adelaide, Australia.; Laboratory for Human Neurophysiology and Genetics, College of Medicine and Public Health, Flinders University, Adelaide, Australia.
Proud CG; Lifelong Health Theme, South Australian Health & Medical Research Institute, Adelaide, Australia .; School of Biological Sciences, University of Adelaide, Adelaide, Australia.
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Jul 17; Vol. 295 (29), pp. 9855-9867. Date of Electronic Publication: 2020 May 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium/*metabolism
Endoplasmic Reticulum Stress/*drug effects
Neoplasm Proteins/*biosynthesis
Neoplasms/*metabolism
Protein Biosynthesis/*drug effects
Protein Synthesis Inhibitors/*pharmacology
A549 Cells ; Eukaryotic Initiation Factor-2/metabolism ; HEK293 Cells ; HeLa Cells ; Humans ; Neoplasms/drug therapy ; Neoplasms/pathology ; Peptide Elongation Factor 2/metabolism ; Phosphorylation/drug effects ; Protein Synthesis Inhibitors/chemistry ; Repressor Proteins/metabolism
Czasopismo naukowe
Tytuł :
Exploring Drug Treatment Patterns Based on the Action of Drug and Multilayer Network Model.
Autorzy :
Yu L; School of Computer Science and Technology, Xidian University, Xi'an 710071, China.
Shi Y; School of Computer Science and Technology, Xidian University, Xi'an 710071, China.
Zou Q; Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology, Chengdu 650004, China.
Wang S; Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.
Zheng L; School of Computer Science and Technology, Liaocheng University, Liaocheng 252000, China.
Gao L; School of Computer Science and Technology, Xidian University, Xi'an 710071, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Jul 16; Vol. 21 (14). Date of Electronic Publication: 2020 Jul 16.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Regulatory Networks/*drug effects
Hydroxamic Acids/*pharmacology
Protein Interaction Maps/*drug effects
Protein Synthesis Inhibitors/*pharmacology
Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Drug Repositioning ; Female ; Gene Ontology ; Humans ; Hydroxamic Acids/therapeutic use ; Leukemia/drug therapy ; Leukemia/genetics ; Leukemia/metabolism ; Male ; Models, Biological ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/metabolism ; Protein Synthesis Inhibitors/therapeutic use ; Transcriptome/drug effects
Czasopismo naukowe
Tytuł :
Insights into the improved macrolide inhibitory activity from the high-resolution cryo-EM structure of dirithromycin bound to the E. coli 70S ribosome.
Autorzy :
Pichkur EB; Petersburg Nuclear Physics Institute named by B.P. Konstantinov of NRC 'Kurchatov Institute,' Gatchina, 188300, Russia.; National Research Center 'Kurchatov Institute,' Moscow, 123182, Russia.
Paleskava A; Petersburg Nuclear Physics Institute named by B.P. Konstantinov of NRC 'Kurchatov Institute,' Gatchina, 188300, Russia.; Peter the Great St. Petersburg Polytechnic University, Saint Petersburg, 195251, Russia.
Tereshchenkov AG; Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119992, Russia.
Kasatsky P; Petersburg Nuclear Physics Institute named by B.P. Konstantinov of NRC 'Kurchatov Institute,' Gatchina, 188300, Russia.
Komarova ES; Department of Bioengineering and Bioinformatics and A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119992, Russia.; Skolkovo Institute of Science and Technology, Skolkovo, Moscow region, 143025, Russia.
Shiriaev DI; Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119992, Russia.
Bogdanov AA; Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119992, Russia.
Dontsova OA; Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119992, Russia.; Skolkovo Institute of Science and Technology, Skolkovo, Moscow region, 143025, Russia.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia.
Osterman IA; Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119992, Russia.; Skolkovo Institute of Science and Technology, Skolkovo, Moscow region, 143025, Russia.
Sergiev PV; Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119992, Russia.; Skolkovo Institute of Science and Technology, Skolkovo, Moscow region, 143025, Russia.
Polikanov YS; Departments of Biological Sciences and Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois 60607, USA.; Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, Illinois 60607, USA.
Myasnikov AG; Petersburg Nuclear Physics Institute named by B.P. Konstantinov of NRC 'Kurchatov Institute,' Gatchina, 188300, Russia.; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.; Centre for Integrative Biology, IGBMC, CNRS, Inserm, Université de Strasbourg, Illkirch, 67404, France.
Konevega AL; Petersburg Nuclear Physics Institute named by B.P. Konstantinov of NRC 'Kurchatov Institute,' Gatchina, 188300, Russia.; National Research Center 'Kurchatov Institute,' Moscow, 123182, Russia.; Peter the Great St. Petersburg Polytechnic University, Saint Petersburg, 195251, Russia.
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Źródło :
RNA (New York, N.Y.) [RNA] 2020 Jun; Vol. 26 (6), pp. 715-723. Date of Electronic Publication: 2020 Mar 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Bacterial Agents/*chemistry
Erythromycin/*analogs & derivatives
Protein Synthesis Inhibitors/*chemistry
Ribosomes/*chemistry
Anti-Bacterial Agents/pharmacology ; Cryoelectron Microscopy ; Erythromycin/chemistry ; Erythromycin/pharmacology ; Escherichia coli/genetics ; Models, Molecular ; Protein Biosynthesis/drug effects ; Protein Synthesis Inhibitors/pharmacology ; RNA, Ribosomal, 23S/chemistry
Czasopismo naukowe
Tytuł :
Identification of nagilactone E as a protein synthesis inhibitor with anticancer activity.
Autorzy :
Zhang LL; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.; School of Medicine, Chengdu University, Chengdu, 610106, China.
Guo J; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430074, China.
Jiang XM; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.
Chen XP; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.
Wang YT; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.
Li A; College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 401331, China.
Lin LG; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China. .
Li H; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430074, China. .
Lu JJ; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China. .
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Źródło :
Acta pharmacologica Sinica [Acta Pharmacol Sin] 2020 May; Vol. 41 (5), pp. 698-705. Date of Electronic Publication: 2020 Feb 11.
Typ publikacji :
Journal Article
MeSH Terms :
Activating Transcription Factor 4/*antagonists & inhibitors
Antineoplastic Agents/*pharmacology
Cyclin-Dependent Kinase Inhibitor p21/*antagonists & inhibitors
Diterpenes/*pharmacology
NF-E2-Related Factor 2/*antagonists & inhibitors
Protein Synthesis Inhibitors/*pharmacology
STAT3 Transcription Factor/*antagonists & inhibitors
A549 Cells ; Activating Transcription Factor 4/biosynthesis ; Activating Transcription Factor 4/genetics ; Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/isolation & purification ; Cell Proliferation/drug effects ; Computational Biology ; Cyclin-Dependent Kinase Inhibitor p21/biosynthesis ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Diterpenes/administration & dosage ; Diterpenes/isolation & purification ; Drug Screening Assays, Antitumor ; Humans ; Injections, Intraperitoneal ; Male ; Mice ; Mice, SCID ; Molecular Docking Simulation ; NF-E2-Related Factor 2/biosynthesis ; NF-E2-Related Factor 2/genetics ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology ; Protein Synthesis Inhibitors/administration & dosage ; Protein Synthesis Inhibitors/isolation & purification ; STAT3 Transcription Factor/biosynthesis ; STAT3 Transcription Factor/genetics ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Ammonium chloride administration prior to exercise has muscle‐specific effects on mitochondrial and myofibrillar protein synthesis in rats.
Autorzy :
Genders, Amanda J. (AUTHOR)
Marin, Evelyn C. (AUTHOR)
Bass, Joseph J. (AUTHOR)
Kuang, Jujiao (AUTHOR)
Saner, Nicholas J. (AUTHOR)
Smith, Ken (AUTHOR)
Atherton, Philip J. (AUTHOR)
Bishop, David J. (AUTHOR)
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Źródło :
Physiological Reports. Mar2021, Vol. 9 Issue 6, p1-14. 14p.
Czasopismo naukowe
Tytuł :
Screening for proteins related to the biosynthesis of hispidin and its derivatives in Phellinus igniarius using iTRAQ proteomic analysis.
Autorzy :
Guo, Jinjing (AUTHOR)
Liu, Xiaoxi (AUTHOR)
Li, Yuanjie (AUTHOR)
Ji, Hongyan (AUTHOR)
Liu, Cheng (AUTHOR)
Zhou, Li (AUTHOR)
Huang, Yu (AUTHOR)
Bai, Changcai (AUTHOR)
Jiang, Zhibo (AUTHOR)
Wu, Xiuli (AUTHOR)
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Źródło :
BMC Microbiology. 3/12/2021, Vol. 21 Issue 1, p1-16. 16p.
Czasopismo naukowe
Tytuł :
Kinetic Target-Guided Synthesis: Reaching the Age of Maturity.
Autorzy :
Bosc D; Univ. Lille, Inserm, Institut Pasteur de Lille, U1177-Drugs and Molecules for Living Systems, F-59000 Lille, France.
Camberlein V; Univ. Lille, Inserm, Institut Pasteur de Lille, U1177-Drugs and Molecules for Living Systems, F-59000 Lille, France.
Gealageas R; Univ. Lille, Inserm, Institut Pasteur de Lille, U1177-Drugs and Molecules for Living Systems, F-59000 Lille, France.
Castillo-Aguilera O; Univ. Lille, Inserm, Institut Pasteur de Lille, U1177-Drugs and Molecules for Living Systems, F-59000 Lille, France.
Deprez B; Univ. Lille, Inserm, Institut Pasteur de Lille, U1177-Drugs and Molecules for Living Systems, F-59000 Lille, France.
Deprez-Poulain R; Univ. Lille, Inserm, Institut Pasteur de Lille, U1177-Drugs and Molecules for Living Systems, F-59000 Lille, France.; Institut Universitaire de France, F- 75005 Paris, France.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Apr 23; Vol. 63 (8), pp. 3817-3833. Date of Electronic Publication: 2019 Dec 24.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Chemistry, Pharmaceutical/*trends
Drug Delivery Systems/*trends
Drug Discovery/*trends
Protease Inhibitors/*chemistry
Protein Synthesis Inhibitors/*chemistry
Animals ; Chemistry, Pharmaceutical/methods ; Drug Delivery Systems/methods ; Drug Discovery/methods ; Humans ; Kinetics ; Protease Inhibitors/administration & dosage ; Protease Inhibitors/pharmacokinetics ; Protein Synthesis Inhibitors/administration & dosage ; Protein Synthesis Inhibitors/pharmacokinetics
Czasopismo naukowe
Tytuł :
Dynamic association of human Ebp1 with the ribosome.
Autorzy :
Bhaskar V; Friedrich Miescher Institute for Biomedical Research, CH-4058 Basel, Switzerland.
Desogus J; Friedrich Miescher Institute for Biomedical Research, CH-4058 Basel, Switzerland.; University of Basel, CH-4003 Basel, Switzerland.
Graff-Meyer A; Friedrich Miescher Institute for Biomedical Research, CH-4058 Basel, Switzerland.
Schenk AD; Friedrich Miescher Institute for Biomedical Research, CH-4058 Basel, Switzerland.
Cavadini S; Friedrich Miescher Institute for Biomedical Research, CH-4058 Basel, Switzerland.
Chao JA; Friedrich Miescher Institute for Biomedical Research, CH-4058 Basel, Switzerland.
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Źródło :
RNA (New York, N.Y.) [RNA] 2021 Apr; Vol. 27 (4), pp. 411-419. Date of Electronic Publication: 2021 Jan 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Biosynthesis*/drug effects
Adaptor Proteins, Signal Transducing/*chemistry
RNA, Ribosomal/*chemistry
RNA-Binding Proteins/*chemistry
Ribosomal Proteins/*chemistry
Ribosomes/*chemistry
Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Binding Sites ; Cryoelectron Microscopy ; Humans ; Models, Molecular ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Protein Synthesis Inhibitors/pharmacology ; Puromycin/pharmacology ; RNA, Ribosomal/genetics ; RNA, Ribosomal/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Ribosomal Proteins/genetics ; Ribosomal Proteins/metabolism ; Ribosomes/genetics ; Ribosomes/metabolism ; Thermodynamics
Czasopismo naukowe
Tytuł :
Translation error clusters induced by aminoglycoside antibiotics.
Autorzy :
Wohlgemuth I; Department of Physical Biochemistry, Max Planck Institute for Biophysical Chemistry, Goettingen, Germany. .
Garofalo R; Department of Physical Biochemistry, Max Planck Institute for Biophysical Chemistry, Goettingen, Germany.
Samatova E; Department of Physical Biochemistry, Max Planck Institute for Biophysical Chemistry, Goettingen, Germany.
Günenç AN; Department of Physical Biochemistry, Max Planck Institute for Biophysical Chemistry, Goettingen, Germany.
Lenz C; Bioanalytical Mass Spectrometry Group, Max Planck Institute for Biophysical Chemistry, Goettingen, Germany.; Institute of Clinical Chemistry, Bioanalytics, University Medical Center Goettingen, Goettingen, Germany.
Urlaub H; Bioanalytical Mass Spectrometry Group, Max Planck Institute for Biophysical Chemistry, Goettingen, Germany. .; Institute of Clinical Chemistry, Bioanalytics, University Medical Center Goettingen, Goettingen, Germany. .
Rodnina MV; Department of Physical Biochemistry, Max Planck Institute for Biophysical Chemistry, Goettingen, Germany. .
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Źródło :
Nature communications [Nat Commun] 2021 Mar 23; Vol. 12 (1), pp. 1830. Date of Electronic Publication: 2021 Mar 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aminoglycosides/*pharmacology
Anti-Bacterial Agents/*pharmacology
Escherichia coli/*drug effects
Peptide Elongation Factor Tu/*metabolism
Protein Biosynthesis/*genetics
Proteome/*genetics
Ribosomes/*metabolism
Stress, Physiological/*drug effects
Escherichia coli/genetics ; Escherichia coli/metabolism ; Mass Spectrometry ; Mutation, Missense ; Nebramycin/analogs & derivatives ; Nebramycin/pharmacology ; Peptide Elongation Factor Tu/genetics ; Peptides/genetics ; Peptides/metabolism ; Protein Biosynthesis/drug effects ; Protein Synthesis Inhibitors/pharmacology ; Proteome/drug effects ; Proteome/metabolism ; Proteomics ; Recombinant Proteins ; Ribosomes/drug effects ; Streptomycin/pharmacology ; Stress, Physiological/genetics
Czasopismo naukowe
Tytuł :
The role of cellular iron deficiency in controlling iron export.
Autorzy :
Link C; Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany; Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, Heidelberg, Germany.
Knopf JD; Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany.
Marques O; Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, Heidelberg, Germany; Molecular Medicine Partnership Unit, University of Heidelberg, Heidelberg, Germany.
Lemberg MK; Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany. Electronic address: .
Muckenthaler MU; Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, Heidelberg, Germany; Molecular Medicine Partnership Unit, University of Heidelberg, Heidelberg, Germany. Electronic address: .
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Źródło :
Biochimica et biophysica acta. General subjects [Biochim Biophys Acta Gen Subj] 2021 Mar; Vol. 1865 (3), pp. 129829. Date of Electronic Publication: 2020 Dec 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cation Transport Proteins/*genetics
Hepcidins/*genetics
Iron/*deficiency
Cation Transport Proteins/metabolism ; Cycloheximide/pharmacology ; Deferoxamine/pharmacology ; Gene Expression Regulation ; HeLa Cells ; Hepcidins/metabolism ; Humans ; Ion Transport/drug effects ; Iron Chelating Agents/pharmacology ; Protein Binding/drug effects ; Protein Synthesis Inhibitors/pharmacology ; Protein Transport/drug effects ; Proteolysis/drug effects ; Signal Transduction
Czasopismo naukowe
Tytuł :
Inhibiting Translation Elongation with SVC112 Suppresses Cancer Stem Cells and Inhibits Growth in Head and Neck Squamous Carcinoma.
Autorzy :
Keysar SB; Division of Medical Oncology, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado.
Gomes N; SuviCa, Inc., Boulder, Colorado.
Miller B; Division of Medical Oncology, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado.
Jackson BC; Division of Medical Oncology, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado.
Le PN; Division of Medical Oncology, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado.
Morton JJ; Division of Medical Oncology, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado.
Reisinger J; Division of Medical Oncology, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado.
Chimed TS; Division of Medical Oncology, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado.
Gomez KE; Division of Medical Oncology, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado.
Nieto C; Division of Medical Oncology, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado.
Frederick B; SuviCa, Inc., Boulder, Colorado.
Pronk GJ; SuviCa, Inc., Boulder, Colorado.
Somerset HL; Department of Pathology, University of Colorado School of Medicine, and VA Medical Center, Aurora, Colorado.
Tan AC; Division of Medical Oncology, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado.; Department of Biostatistics and Informatics, University of Colorado School of Public Health, Aurora, Colorado.
Wang XJ; Department of Pathology, University of Colorado School of Medicine, and VA Medical Center, Aurora, Colorado.; Gates Center for Regenerative Medicine, University of Colorado School of Medicine, Aurora, Colorado.
Raben D; Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, Colorado.
Su TT; SuviCa, Inc., Boulder, Colorado. .; Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado.
Jimeno A; Division of Medical Oncology, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado. .; Gates Center for Regenerative Medicine, University of Colorado School of Medicine, Aurora, Colorado.
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Źródło :
Cancer research [Cancer Res] 2020 Mar 01; Vol. 80 (5), pp. 1183-1198. Date of Electronic Publication: 2020 Jan 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Head and Neck Neoplasms/*therapy
Neoplastic Stem Cells/*drug effects
Peptides, Cyclic/*pharmacology
Protein Synthesis Inhibitors/*pharmacology
Squamous Cell Carcinoma of Head and Neck/*therapy
Animals ; Cell Cycle/drug effects ; Cell Cycle/radiation effects ; Cell Line, Tumor ; Chemoradiotherapy/methods ; DNA Damage/radiation effects ; DNA Repair/drug effects ; Dose-Response Relationship, Radiation ; Female ; Head and Neck Neoplasms/pathology ; Humans ; Mice ; Neoplasm Recurrence, Local ; Neoplastic Stem Cells/radiation effects ; Peptide Chain Elongation, Translational/drug effects ; Peptides, Cyclic/chemistry ; Protein Synthesis Inhibitors/therapeutic use ; Radiotherapy Dosage ; Squamous Cell Carcinoma of Head and Neck/pathology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Gentamicin induces COL17A1 nonsense mutation readthrough in junctional epidermolysis bullosa.
Autorzy :
Li Y; Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Shen J; Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Liang J; Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Zheng L; Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Chen F; Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Yao Z; Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Li M; Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.; Center for Rare Disease, Shanghai, China.
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Źródło :
The Journal of dermatology [J Dermatol] 2020 Mar; Vol. 47 (3), pp. e82-e83. Date of Electronic Publication: 2020 Jan 10.
Typ publikacji :
Case Reports; Letter
MeSH Terms :
Autoantigens/*genetics
Codon, Nonsense/*drug effects
Epidermolysis Bullosa, Junctional/*genetics
Gentamicins/*therapeutic use
Non-Fibrillar Collagens/*genetics
Protein Synthesis Inhibitors/*therapeutic use
Gentamicins/pharmacology ; Humans ; Infant ; Male ; Protein Synthesis Inhibitors/pharmacology
Raport

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