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Tytuł:
Siglec-6 Signaling Uses Src Kinase Tyrosine Phosphorylation and SHP-2 Recruitment.
Autorzy:
Stefanski AL; Department of Obstetrics and Gynecology, School of Medicine, University of Colorado, Aurora, CO 80309, USA.
Renecle MD; Department of Obstetrics and Gynecology, School of Medicine, University of Colorado, Aurora, CO 80309, USA.
Kramer A; Department of Obstetrics and Gynecology, School of Medicine, University of Colorado, Aurora, CO 80309, USA.
Sehgal S; Department of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Narasimhan P; Department of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Rumer KK; Department of Obstetrics and Gynecology, School of Medicine, University of Colorado, Aurora, CO 80309, USA.
Winn VD; Department of Obstetrics and Gynecology, School of Medicine, University of Colorado, Aurora, CO 80309, USA.; Department of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, CA 94305, USA.
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Źródło:
Cells [Cells] 2022 Oct 29; Vol. 11 (21). Date of Electronic Publication: 2022 Oct 29.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Pre-Eclampsia*/metabolism
src-Family Kinases*/metabolism
Lectins*/metabolism
Protein Tyrosine Phosphatase, Non-Receptor Type 11*/metabolism
Female ; Humans ; Pregnancy ; Amino Acid Motifs/genetics ; Amino Acid Sequence ; Phosphorylation ; Placenta/metabolism ; Protein Tyrosine Phosphatase, Non-Receptor Type 6 ; Sialic Acid Binding Immunoglobulin-like Lectins/metabolism ; Tyrosine/metabolism ; Antigens, Differentiation, Myelomonocytic/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Atomistic ensemble of active SHP2 phosphatase.
Autorzy:
Anselmi M; Theoretical Physics and Center for Biophysics, Saarland University, 66123, Saarbrücken, Germany. .
Hub JS; Theoretical Physics and Center for Biophysics, Saarland University, 66123, Saarbrücken, Germany. .
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Źródło:
Communications biology [Commun Biol] 2023 Dec 21; Vol. 6 (1), pp. 1289. Date of Electronic Publication: 2023 Dec 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Tyrosine Phosphatase, Non-Receptor Type 11*/genetics
Protein Tyrosine Phosphatase, Non-Receptor Type 11*/metabolism
Neoplasms*
Humans ; Scattering, Small Angle ; X-Ray Diffraction ; Mutation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Discovery of a SHP2 Degrader with In Vivo Anti-Tumor Activity.
Autorzy:
Miao J; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.
Bai Y; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.
Miao Y; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.
Qu Z; Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.
Dong J; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.
Zhang RY; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.
Aggarwal D; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.
Jassim BA; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.
Nguyen Q; Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.
Zhang ZY; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.; Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.; Institute for Cancer Research, Purdue University, West Lafayette, IN 47907, USA.; Institute for Drug Discovery, Purdue University, West Lafayette, IN 47907, USA.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Oct 06; Vol. 28 (19). Date of Electronic Publication: 2023 Oct 06.
Typ publikacji:
Journal Article
MeSH Terms:
Protein Tyrosine Phosphatase, Non-Receptor Type 11*
Neoplasms*/drug therapy
Humans ; Animals ; Mice ; Cell Line ; Proteasome Endopeptidase Complex/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Proteolysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Pan-cancer analysis revealing that PTPN2 is an indicator of risk stratification for acute myeloid leukemia.
Autorzy:
Wang X; Department of Urology, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan, 430071, China.
Wu S; Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Sun L; Department of Urology, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan, 430071, China.
Jin P; Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Zhang J; Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Liu W; Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Zhan Z; Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Wang Z; School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, Hubei Province, China.
Liu X; Department of Pathology, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan, 430071, China. .
He L; Department of Urology, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan, 430071, China. .; Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China. .
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Źródło:
Scientific reports [Sci Rep] 2023 Oct 26; Vol. 13 (1), pp. 18372. Date of Electronic Publication: 2023 Oct 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Tyrosine Phosphatase, Non-Receptor Type 2*/genetics
Leukemia, Myeloid, Acute*/diagnosis
Leukemia, Myeloid, Acute*/genetics
Humans ; Carcinogenesis ; Biomarkers ; Risk Assessment ; Prognosis ; Tumor Microenvironment/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
In silico mutagenesis-based designing of oncogenic SHP2 peptide to inhibit cancer progression.
Autorzy:
Shahab M; State Key Laboratories of Chemical Resources Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.
Khan SS; College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, China.
Zulfat M; Department of Chemistry, Computational Medicinal Chemistry Laboratory, UCSS, Abdul Wali Khan University, Mardan, Pakistan.
Bin Jardan YA; Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Mekonnen AB; Department of Biology, Bahir Dar University, P.O. Box 79, Bahir Dar, Ethiopia. .
Bourhia M; Higher Institute of Nursing Professions and Technical Health, 70000, Laayoune, Morocco.
Zheng G; State Key Laboratories of Chemical Resources Engineering, Beijing University of Chemical Technology, Beijing, 100029, China. .
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Źródło:
Scientific reports [Sci Rep] 2023 Jun 21; Vol. 13 (1), pp. 10088. Date of Electronic Publication: 2023 Jun 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Tyrosine Phosphatase, Non-Receptor Type 11*/metabolism
Neoplasms*/genetics
Humans ; Peptides/genetics ; Peptides/pharmacology ; Mutagenesis ; Molecular Dynamics Simulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Protein tyrosine phosphatase 1B contributes to neuropathic pain by aggravating NF-κB and glial cells activation-mediated neuroinflammation via promoting endoplasmic reticulum stress.
Autorzy:
Jiao B; Department of Anesthesiology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Zhang W; Department of Anesthesiology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Zhang C; Department of Anesthesiology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Zhang K; Department of Anesthesiology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Cao X; Department of Anesthesiology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Yu S; Department of Anesthesiology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Zhang X; Department of Anesthesiology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
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Źródło:
CNS neuroscience & therapeutics [CNS Neurosci Ther] 2024 Feb; Vol. 30 (2), pp. e14609.
Typ publikacji:
Journal Article
MeSH Terms:
Neuralgia*/metabolism
NF-kappa B*
Animals ; Male ; Rats ; Cytokines ; Endoplasmic Reticulum Stress ; Endoribonucleases/therapeutic use ; Hyperalgesia/drug therapy ; Hyperalgesia/etiology ; Neuroglia/metabolism ; Neuroinflammatory Diseases ; Protein Serine-Threonine Kinases ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/metabolism ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/therapeutic use ; Rats, Sprague-Dawley ; NF-kappa B p50 Subunit/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Autoimmunity-associated allele of tyrosine phosphatase gene PTPN22 enhances anti-viral immunity.
Autorzy:
Orozco, Robin C. (AUTHOR)
Marquardt, Kristi (AUTHOR)
Pratumchai, Isaraphorn (AUTHOR)
Shaikh, Anam Fatima (AUTHOR)
Mowen, Kerri (AUTHOR)
Domissy, Alain (AUTHOR)
Teijaro, John R. (AUTHOR)
Sherman, Linda A. (AUTHOR)
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Źródło:
PLoS Pathogens. 3/21/2024, Vol. 20 Issue 3, p1-28. 28p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Differential contribution of canonical and noncanonical NLGN3 pathways to early social development and memory performance.
Autorzy:
Li, Lin-Yu (AUTHOR)
Imai, Ayako (AUTHOR)
Izumi, Hironori (AUTHOR)
Inoue, Ran (AUTHOR)
Koshidaka, Yumie (AUTHOR)
Takao, Keizo (AUTHOR)
Mori, Hisashi (AUTHOR)
Yoshida, Tomoyuki (AUTHOR)
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Źródło:
Molecular Brain. 3/12/2024, Vol. 17 Issue 1, p1-14. 14p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Vanadium Complexes with Thioanilide Derivatives of Amino Acids: Inhibition of Human Phosphatases and Specificity in Various Cell Models of Metabolic Disturbances.
Autorzy:
Kazek, Grzegorz (AUTHOR)
Głuch-Lutwin, Monika (AUTHOR)
Mordyl, Barbara (AUTHOR)
Menaszek, Elżbieta (AUTHOR)
Kubacka, Monika (AUTHOR)
Jurowska, Anna (AUTHOR)
Cież, Dariusz (AUTHOR)
Trzewik, Bartosz (AUTHOR)
Szklarzewicz, Janusz (AUTHOR)
Papież, Monika A. (AUTHOR)
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Źródło:
Pharmaceuticals (14248247). Feb2024, Vol. 17 Issue 2, p229. 35p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Association of TRAIL receptor with phosphatase SHP-1 enables repressing T cell receptor signaling and T cell activation through inactivating Lck.
Autorzy:
Chyuan IT; School of Medicine, National Tsing Hua University, Hsinchu, 30013, Taiwan.; Department of Medical Research, Cathay General Hospital, Taipei, 10630, Taiwan.; Department of Internal Medicine, Cathay General Hospital, Taipei, 10630, Taiwan.
Liao HJ; Department of Medical Research, Far Eastern Memorial Hospital, New Taipei City, Taipei, 22000, Taiwan.; Institute of Biopharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 112304, Taiwan.
Tan TH; Immunology Research Center, National Health Research Institutes, Zhunan, 35053, Taiwan.; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, 77030, USA.
Chuang HC; Immunology Research Center, National Health Research Institutes, Zhunan, 35053, Taiwan.
Chu YC; Department of Medical Research, Cathay General Hospital, Taipei, 10630, Taiwan.
Pan MH; Department of Medical Research, Cathay General Hospital, Taipei, 10630, Taiwan.
Wu CS; Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City, Taipei, 22000, Taiwan.
Chu CL; Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, 10051, Taiwan.
Sheu BC; Department of Obstetrics and Gynecology, College of Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, 10002, Taiwan.; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, 10051, Taiwan.
Hsu PN; Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, 10051, Taiwan. .; Department of Internal Medicine and Graduate Institute of Immunology, College of Medicine, National Taiwan University, 1 Jen-Ai Rd., Sec. 1, Taipei, 10051, Taiwan. .; Department of Internal Medicine, National Taiwan University Hospital, Taipei, 10002, Taiwan. .
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Źródło:
Journal of biomedical science [J Biomed Sci] 2024 Mar 27; Vol. 31 (1), pp. 33. Date of Electronic Publication: 2024 Mar 27.
Typ publikacji:
Journal Article
MeSH Terms:
Receptors, TNF-Related Apoptosis-Inducing Ligand*/metabolism
Receptors, Antigen, T-Cell*/metabolism
Humans ; Jurkat Cells ; Protein Tyrosine Phosphatase, Non-Receptor Type 6/metabolism ; Signal Transduction ; Protein Tyrosine Phosphatases/genetics ; Protein Tyrosine Phosphatases/metabolism ; Phosphorylation ; Lymphocyte Activation ; Tyrosine/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Machine learning-based prediction of rheumatoid arthritis with development of ACPA autoantibodies in the presence of non-HLA genes polymorphisms.
Autorzy:
Dudek G; Electrical Engineering Faculty, Czestochowa University of Technology, Czestochowa, Poland.; Faculty of Mathematics and Computer Science, University of Lodz, Lodz, Poland.; Centre for Data Analysis, Modelling and Computational Sciences, University of Lodz, Lodz, Poland.
Sakowski S; Faculty of Mathematics and Computer Science, University of Lodz, Lodz, Poland.; Centre for Data Analysis, Modelling and Computational Sciences, University of Lodz, Lodz, Poland.
Brzezińska O; Department of Rheumatology, Medical University of Lodz, Lodz, Poland.
Sarnik J; Department of Rheumatology, Medical University of Lodz, Lodz, Poland.
Budlewski T; Department of Rheumatology, Medical University of Lodz, Lodz, Poland.
Dragan G; Department of Clinical Chemistry and Biochemistry, Medical University of Lodz, Lodz, Poland.
Poplawska M; Biobank, Department of Immunology and Allergy, Medical University of Lodz, Lodz, Poland.
Poplawski T; Department of Pharmaceutical Microbiology and Biochemistry, Medical University of Lodz, Lodz, Poland.
Bijak M; Biohazard Prevention Centre, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland.
Makowska J; Department of Rheumatology, Medical University of Lodz, Lodz, Poland.
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Źródło:
PloS one [PLoS One] 2024 Mar 22; Vol. 19 (3), pp. e0300717. Date of Electronic Publication: 2024 Mar 22 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Autoantibodies*/genetics
Arthritis, Rheumatoid*/diagnosis
Arthritis, Rheumatoid*/genetics
Humans ; Bayes Theorem ; Genetic Predisposition to Disease ; HLA-DRB1 Chains/genetics ; Polymorphism, Single Nucleotide ; Protein Tyrosine Phosphatase, Non-Receptor Type 22/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Clinical Variability in a Family with Noonan Syndrome with a Homozygous PTPN11 Gene Variant in Two Individuals
Autorzy:
Yıldırım R; Diyarbakır Children’s Hospital, Clinic of Pediatric Endocrinology, Diyarbakır, Turkey
Unal E; Dicle University Faculty of Medicine, Department of Pediatric Endocrinology, Diyarbakır, Turkey
Özalkak Ş; Diyarbakır Children’s Hospital, Clinic of Pediatric Endocrinology, Diyarbakır, Turkey
Akalın A; Diyarbakır Children’s Hospital, Clinic of Pediatric Genetics, Diyarbakır, Turkey
Aykut A; Ege University Faculty of Medicine, Department of Genetics, İzmir, Turkey
Yılmaz N; Diyarbakır Children’s Hospital, Department of Pediatric Psychiatry, Diyarbakır, Turkey
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Źródło:
Journal of clinical research in pediatric endocrinology [J Clin Res Pediatr Endocrinol] 2024 Mar 11; Vol. 16 (1), pp. 76-83. Date of Electronic Publication: 2023 Oct 17.
Typ publikacji:
Journal Article
MeSH Terms:
Noonan Syndrome*/diagnosis
Noonan Syndrome*/genetics
Dwarfism*
Humans ; Protein Tyrosine Phosphatase, Non-Receptor Type 11/genetics ; Heterozygote ; Phenotype
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
New dammarane-type triterpenoids from hydrolyzate of total Gynostemma pentaphyllum saponins with protein tyrosine phosphatase 1B inhibitory activity.
Autorzy:
Tan D; Guizhou Engineering Research Center of Industrial Key-technology for Dendrobium Nobile, Zunyi Medical University, Zunyi, Guizhou, China.; Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, China.
Wang J; Guizhou Engineering Research Center of Industrial Key-technology for Dendrobium Nobile, Zunyi Medical University, Zunyi, Guizhou, China.
Wang X; Guizhou Engineering Research Center of Industrial Key-technology for Dendrobium Nobile, Zunyi Medical University, Zunyi, Guizhou, China.
Qin L; Guizhou Engineering Research Center of Industrial Key-technology for Dendrobium Nobile, Zunyi Medical University, Zunyi, Guizhou, China.; Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, China.
Du Y; Guizhou Engineering Research Center of Industrial Key-technology for Dendrobium Nobile, Zunyi Medical University, Zunyi, Guizhou, China.; Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, China.
Zhao C; Guizhou Engineering Research Center of Industrial Key-technology for Dendrobium Nobile, Zunyi Medical University, Zunyi, Guizhou, China.
Liu P; Guizhou Engineering Research Center of Industrial Key-technology for Dendrobium Nobile, Zunyi Medical University, Zunyi, Guizhou, China.
Zhang Q; Guizhou Engineering Research Center of Industrial Key-technology for Dendrobium Nobile, Zunyi Medical University, Zunyi, Guizhou, China.; Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, China.
Ma F; Guizhou Engineering Research Center of Industrial Key-technology for Dendrobium Nobile, Zunyi Medical University, Zunyi, Guizhou, China.; Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, China.
Xie J; Guizhou Engineering Research Center of Industrial Key-technology for Dendrobium Nobile, Zunyi Medical University, Zunyi, Guizhou, China.; Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, China.
Wu D; Guizhou Engineering Research Center of Industrial Key-technology for Dendrobium Nobile, Zunyi Medical University, Zunyi, Guizhou, China.; Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, China.
He Y; Guizhou Engineering Research Center of Industrial Key-technology for Dendrobium Nobile, Zunyi Medical University, Zunyi, Guizhou, China.; Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, China.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2281263. Date of Electronic Publication: 2023 Nov 15.
Typ publikacji:
Journal Article
MeSH Terms:
Saponins*/chemistry
Diabetes Mellitus, Type 2*
Triterpenes*/chemistry
Gynostemma/chemistry ; Gynostemma/metabolism ; Protein Tyrosine Phosphatase, Non-Receptor Type 1 ; Molecular Docking Simulation ; Glucose ; Dammaranes
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The PTP1B selective inhibitor MSI-1436 mitigates Tunicamycin-induced ER stress in human hepatocarcinoma cell line through XBP1 splicing modulation.
Autorzy:
Bourebaba L; Faculty of Biology and Animal Science, Department of Experimental Biology, Wrocław University of Environmental and Life Sciences, Wrocław, Poland.; International Institute of Translational Medicine, Jesionowa, Wisznia Mała, Poland.
Komakula SSB; Faculty of Biology and Animal Science, Department of Experimental Biology, Wrocław University of Environmental and Life Sciences, Wrocław, Poland.
Weiss C; Faculty of Biology and Animal Science, Department of Experimental Biology, Wrocław University of Environmental and Life Sciences, Wrocław, Poland.; PferdePraxis Dr. Med. Vet. Daniel Weiss, Freienbach, Switzerland.
Adrar N; Faculty of Biology and Animal Science, Department of Experimental Biology, Wrocław University of Environmental and Life Sciences, Wrocław, Poland.
Marycz K; Faculty of Biology and Animal Science, Department of Experimental Biology, Wrocław University of Environmental and Life Sciences, Wrocław, Poland.; International Institute of Translational Medicine, Jesionowa, Wisznia Mała, Poland.; Department of Medicine and Epidemiology, UC Davis School of Veterinary Medicine, Davis, CA, United States of America.
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Źródło:
PloS one [PLoS One] 2023 Jan 17; Vol. 18 (1), pp. e0278566. Date of Electronic Publication: 2023 Jan 17 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis*
Endoplasmic Reticulum Stress*
Signal Transduction*
X-Box Binding Protein 1*/genetics
Protein Tyrosine Phosphatase, Non-Receptor Type 1*/antagonists & inhibitors
Humans ; Cell Line ; Reactive Oxygen Species/pharmacology ; Tunicamycin/pharmacology ; RNA Splicing
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
SHP-1 tyrosine phosphatase binding to c-Src kinase phosphor-dependent conformations: A comparative structural framework.
Autorzy:
Gul M; National Center for Bioinformatics, Quaid-i-Azam University, Islamabad, Pakistan.
Navid A; National Center for Bioinformatics, Quaid-i-Azam University, Islamabad, Pakistan.
Fakhar M; National Center for Bioinformatics, Quaid-i-Azam University, Islamabad, Pakistan.
Rashid S; National Center for Bioinformatics, Quaid-i-Azam University, Islamabad, Pakistan.
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Źródło:
PloS one [PLoS One] 2023 Jan 13; Vol. 18 (1), pp. e0278448. Date of Electronic Publication: 2023 Jan 13 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
CSK Tyrosine-Protein Kinase*/chemistry
Protein Tyrosine Phosphatase, Non-Receptor Type 6*/chemistry
src Homology Domains*
Phosphorylation ; SH2 Domain-Containing Protein Tyrosine Phosphatases/chemistry ; Neoplasms
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Binding Free Energy Calculation Based on the Fragment Molecular Orbital Method and Its Application in Designing Novel SHP-2 Allosteric Inhibitors.
Autorzy:
Yuan, Zhen (AUTHOR)
Chen, Xingyu (AUTHOR)
Fan, Sisi (AUTHOR)
Chang, Longfeng (AUTHOR)
Chu, Linna (AUTHOR)
Zhang, Ying (AUTHOR)
Wang, Jie (AUTHOR)
Li, Shuang (AUTHOR)
Xie, Jinxin (AUTHOR)
Hu, Jianguo (AUTHOR)
Miao, Runyu (AUTHOR)
Zhu, Lili (AUTHOR)
Zhao, Zhenjiang (AUTHOR)
Li, Honglin (AUTHOR)
Li, Shiliang (AUTHOR)
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Źródło:
International Journal of Molecular Sciences. Jan2024, Vol. 25 Issue 1, p671. 24p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Potential protein tyrosine phosphatase 1B and α-glucosidase inhibitory flavonoids from Erythrina variegata : Experimental and computational results.
Autorzy:
Nguyen, Phi-Hung (AUTHOR)
Trinh, Ngoc-Thao-Vy (AUTHOR)
Do, Thi-Thuy (AUTHOR)
Vu, Thi-Ha (AUTHOR)
To, Dao Cuong (AUTHOR)
Pham, Hong Khuyen Thi (AUTHOR)
Truong, Phu Chi Hieu (AUTHOR)
Pham Van, Kim Thuong (AUTHOR)
Tran, Manh Hung (AUTHOR)
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Źródło:
Journal of Chemical Research. Jan/Feb2024, Vol. 48 Issue 1, p1-11. 11p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Discovery of the SHP2 allosteric inhibitor 2-((3R,4R)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-5-(2,3-dichlorophenyl)-3-methylpyrrolo[2,1-f][1,2,4] triazin-4(3H)-one.
Autorzy:
Luo, Yanmei (AUTHOR)
Li, Jin (AUTHOR)
Zong, Yuliang (AUTHOR)
Sun, Mengxin (AUTHOR)
Zheng, Wan (AUTHOR)
Zhu, Jiapeng (AUTHOR)
Liu, Liu (AUTHOR)
Liu, Bing (AUTHOR)
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Źródło:
Journal of Enzyme Inhibition & Medicinal Chemistry. Dec2023, Vol. 38 Issue 1, p398-404. 7p.
Czasopismo naukowe
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