Temat: "PYRIDINES" - OpacWWW

Skocz do pozycji: 21.

Tytuł:: Synthesis of a 3,7-Disubstituted Isothiazolo[4,3- b ]pyridine as a Potential Inhibitor of Cyclin G-Associated Kinase.
Autorzy:: Grisez T; Department of Chemistry, Sustainable Chemistry for Metals and Molecules, KU Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium.
Ravi NP; Department of Chemistry, Sustainable Chemistry for Metals and Molecules, KU Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium.
Froeyen M; Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Herestraat 49, P.O. Box 1041, B-3000 Leuven, Belgium.
Schols D; Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, Department of Microbiology, Immunology and Transplantation, KU Leuven, Herestraat 49, P.O. Box 1043, B-3000 Leuven, Belgium.
Van Meervelt L; Department of Chemistry, Biomolecular Architecture, KU Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium.
De Jonghe S; Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, Department of Microbiology, Immunology and Transplantation, KU Leuven, Herestraat 49, P.O. Box 1043, B-3000 Leuven, Belgium.
Dehaen W; Department of Chemistry, Sustainable Chemistry for Metals and Molecules, KU Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2024 Feb 22; Vol. 29 (5). Date of Electronic Publication: 2024 Feb 22.
Typ publikacji:: Journal Article
MeSH Terms:: Pyridines*/pharmacology
Palladium*
Models, Molecular ; Ligands ; Cyclin G ; Catalysis

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Skocz do pozycji: 22.

Tytuł:: The Sphingolipid-Modulating Drug Opaganib Protects against Radiation-Induced Lung Inflammation and Fibrosis: Potential Uses as a Medical Countermeasure and in Cancer Radiotherapy.
Autorzy:: Maines LW; Apogee Biotechnology Corporation, 1214 Research Blvd, Suite 2015, Hummelstown, PA 17036, USA.
Keller SN; Apogee Biotechnology Corporation, 1214 Research Blvd, Suite 2015, Hummelstown, PA 17036, USA.
Smith RA; Apogee Biotechnology Corporation, 1214 Research Blvd, Suite 2015, Hummelstown, PA 17036, USA.
Green CL; Apogee Biotechnology Corporation, 1214 Research Blvd, Suite 2015, Hummelstown, PA 17036, USA.
Smith CD; Apogee Biotechnology Corporation, 1214 Research Blvd, Suite 2015, Hummelstown, PA 17036, USA.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 15; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 15.
Typ publikacji:: Journal Article
MeSH Terms:: Pulmonary Fibrosis*/drug therapy
Pulmonary Fibrosis*/etiology
Pulmonary Fibrosis*/pathology
Medical Countermeasures*
Pneumonia*
Neoplasms*
Pyridines*
Adamantane/*analogs & derivatives
Mice ; Animals ; Humans ; Sphingolipids/metabolism ; Fibrosis ; Inflammation/drug therapy

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Skocz do pozycji: 23.

Tytuł:: Organic Synthesis and Current Understanding of the Mechanisms of CFTR Modulator Drugs Ivacaftor, Tezacaftor, and Elexacaftor.
Autorzy:: Ferreira FC; Biosystems & Integrative Sciences Institute (BioISI), Faculty of Sciences, University of Lisbon, 1749-016 Lisbon, Portugal.
Buarque CD; Department of Chemistry, Pontifical Catholic University of Rio de Janeiro (PUC-Rio), Rio de Janeiro 22435-900, RJ, Brazil.
Lopes-Pacheco M; Biosystems & Integrative Sciences Institute (BioISI), Faculty of Sciences, University of Lisbon, 1749-016 Lisbon, Portugal.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2024 Feb 10; Vol. 29 (4). Date of Electronic Publication: 2024 Feb 10.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Cystic Fibrosis Transmembrane Conductance Regulator*/metabolism
Cystic Fibrosis*/drug therapy
Cystic Fibrosis*/genetics
Cystic Fibrosis*/metabolism
Aminopyridines*
Indoles*
Pyrazoles*
Pyridines*
Pyrrolidines*
Quinolones*
Humans ; Quality of Life ; Benzodioxoles/pharmacology ; Benzodioxoles/therapeutic use ; Aminophenols/pharmacology ; Aminophenols/therapeutic use ; Mutation ; Chemistry Techniques, Synthetic

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Skocz do pozycji: 24.

Tytuł:: Radiological complete response with regorafenib for multiple lung metastases of ascending colon cancer: a case report.
Autorzy:: Kikuchi K; Department of Surgery, Iwate Medical University, 2-1-1 Idaidori, Yahaba, Iwate, 028-3695, Japan. .; Department of Surgery, Kazuno Kosei Hospital, 18 Mukaibatake, Hanawa, Kazuno, Akita, 018-5201, Japan. .
Ogawa M; Department of Surgery, Kazuno Kosei Hospital, 18 Mukaibatake, Hanawa, Kazuno, Akita, 018-5201, Japan.
Sasaki A; Department of Surgery, Iwate Medical University, 2-1-1 Idaidori, Yahaba, Iwate, 028-3695, Japan.; Pokaż więcej
Źródło:: Journal of medical case reports [J Med Case Rep] 2024 Feb 07; Vol. 18 (1), pp. 45. Date of Electronic Publication: 2024 Feb 07.
Typ publikacji:: Case Reports; Journal Article
MeSH Terms:: Colonic Neoplasms*/pathology
Rectal Neoplasms*
Lung Neoplasms*/secondary
Phenylurea Compounds*
Pyridines*
Male ; Humans ; Aged ; Colon, Ascending/pathology ; Bevacizumab/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use

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Skocz do pozycji: 25.

Tytuł:: A single-centre, real-world study of BTK inhibitors for the initial treatment of MYD88 diffuse large B-cell lymphoma.
Autorzy:: Deng T; Department of Hematology, Chongqing Fifth People's Hospital, Chongqing, PR China.
Zhang S; Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
Xiao M; Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
Gu J; Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
Huang L; Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
Zhou X; Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.; Pokaż więcej
Źródło:: Cancer medicine [Cancer Med] 2024 Feb; Vol. 13 (4), pp. e7005.
Typ publikacji:: Journal Article
MeSH Terms:: Myeloid Differentiation Factor 88*/genetics
Lymphoma, Large B-Cell, Diffuse*/drug therapy
Lymphoma, Large B-Cell, Diffuse*/genetics
Lymphoma, Large B-Cell, Diffuse*/pathology
Piperidines*
Pyridines*
Humans ; Aged ; Rituximab/therapeutic use ; Disease-Free Survival ; Retrospective Studies ; Vincristine/adverse effects ; Cyclophosphamide/adverse effects ; Doxorubicin/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Prednisone/adverse effects ; CD79 Antigens/genetics

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Skocz do pozycji: 26.

Tytuł:: Comparative efficacy, quality of life, safety, and tolerability of atogepant and rimegepant in migraine prevention: A matching-adjusted indirect comparison analysis.
Autorzy:: Tassorelli C; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.; Headache Science & Neurorehabilitation Centre, IRCCS C. Mondino Foundation and University of Pavia, Pavia, Italy.
Onishchenko K; AbbVie, London, England.
Halker Singh RB; Mayo Clinic, Scottsdale, AZ, USA.
Duan M; AbbVie, North Chicago, IL, USA.
Dupont-Benjamin L; AbbVie, Courbevoie, France.
Hemstock M; Lumanity, Sheffield, England.
Voller C; Lumanity, London, England.
McAllister P; New England Institute for Neurology & Headache, Stamford, CT, USA.
Nahas SJ; Department of Neurology, Thomas Jefferson University, Philadelphia, PA, USA.
Gandhi P; AbbVie, Florham Park, NJ, USA.
Ailani J; MedStar Georgetown University Hospital, Washington, DC, USA.; Pokaż więcej
Źródło:: Cephalalgia : an international journal of headache [Cephalalgia] 2024 Feb; Vol. 44 (2), pp. 3331024241235156.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Migraine Disorders*/prevention & control
Migraine Disorders*/drug therapy
Piperidines*
Pyridines*
Pyrroles*
Quality of Life*
Spiro Compounds*
Humans ; Tablets/therapeutic use ; Treatment Outcome ; Clinical Trials, Phase III as Topic ; Clinical Trials, Phase II as Topic

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Skocz do pozycji: 27.

Tytuł:: The inhibitory effect of apatinib on different small cell lung cancer cells and in lung cancer-bearing mice and patients.
Autorzy:: Liu M; Department of Pulmonary Medicine, Binzhou People's Hospital, Binzhou, Shandong, China.
Li H; Department of Pulmonary Medicine, Binzhou People's Hospital, Binzhou, Shandong, China.
Guo R; Department of Pulmonary Medicine, Binzhou People's Hospital, Binzhou, Shandong, China.
Yu X; Department of Pulmonary Medicine, Penglai Traditional Chinese Medicine Hospital, Yantai, Shandong, China.
Li Y; Department of Pulmonary Medicine, Qilu Hospital, Shandong University, Jinan, Shandong, China.; Pokaż więcej
Źródło:: The clinical respiratory journal [Clin Respir J] 2024 Feb; Vol. 18 (2), pp. e13738.
Typ publikacji:: Journal Article
MeSH Terms:: Lung Neoplasms*/drug therapy
Small Cell Lung Carcinoma*/drug therapy
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Pyridines*
Humans ; Animals ; Mice ; Cell Line, Tumor ; Signal Transduction ; Cell Proliferation

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Skocz do pozycji: 28.

Tytuł:: Bioequivalence of rimegepant, a small molecule CGRP receptor antagonist, administered as an oral tablet, a sublingual orally disintegrating tablet, and a supralingual orally disintegrating tablet: two phase 1 randomized studies in healthy adults.
Autorzy:: Croop R; Biohaven Pharmaceuticals, New Haven, CT, USA.
Bhardwaj R; Certara USA, Princeton, NJ, USA.
Anderson MS; Certara USA, Princeton, NJ, USA.
Matschke KT; Pfizer Inc., New York, NY, USA.
Hould J; Biohaven Pharmaceuticals, New Haven, CT, USA.
Bertz R; Biohaven Pharmaceuticals, New Haven, CT, USA.
Liu J; Pfizer Inc., New York, NY, USA.
Lipton RB; Albert Einstein College of Medicine, Bronx, NY, USA.; Pokaż więcej
Źródło:: Cephalalgia : an international journal of headache [Cephalalgia] 2024 Feb; Vol. 44 (2), pp. 3331024231219505.
Typ publikacji:: Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial
MeSH Terms:: Calcitonin Gene-Related Peptide Receptor Antagonists*
Piperidines*
Pyridines*
Adult ; Humans ; Administration, Oral ; Area Under Curve ; Cross-Over Studies ; Tablets ; Therapeutic Equivalency ; Adolescent ; Young Adult ; Middle Aged

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Skocz do pozycji: 29.

Tytuł:: Investigation of pharmacokinetic drug interaction between clesacostat and DGAT2 inhibitor ervogastat in healthy adult participants.
Autorzy:: Sawant-Basak A; Clinical Pharmacology, Early Clinical Development, Worldwide Research, Development and Medical, Pfizer Inc., Cambridge, Massachusetts, USA.
Bergman AJ; Clinical Pharmacology, Early Clinical Development, Worldwide Research, Development and Medical, Pfizer Inc., Cambridge, Massachusetts, USA.
Mancuso J; Statistics, Early Clinical Development, Worldwide Research, Development and Medical, Pfizer Inc., Cambridge, Massachusetts, USA.
Tripathy S; Clinical Assay Group, Global Product Development, Pfizer Inc., Groton, Connecticut, USA.
Gosset JR; Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Worldwide Research, Development and Medical, Pfizer Inc., Cambridge, Massachusetts, USA.
Mendes da Costa L; Pfizer Clinical Research Unit, Brussels, Belgium.
Esler WP; Internal Medicine Research Unit, Worldwide Research, Development and Medical, Pfizer Inc., Cambridge, Massachusetts, USA.
Calle RA; Internal Medicine Research Unit, Worldwide Research, Development and Medical, Pfizer Inc., Cambridge, Massachusetts, USA.; Pokaż więcej
Źródło:: Clinical and translational science [Clin Transl Sci] 2024 Feb; Vol. 17 (2), pp. e13687.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Non-alcoholic Fatty Liver Disease*
Pyridines*
Adult ; Humans ; Healthy Volunteers ; Cytochrome P-450 CYP3A ; Enzyme Inhibitors/adverse effects ; Drug Interactions ; Diacylglycerol O-Acyltransferase

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Skocz do pozycji: 30.

Tytuł:: A study protocol for an open-label, single-arm, single-center phase I clinical study on tolerability, safety, and efficacy of dalpiciclib combined with apatinib in the treatment of patients with advanced or metastatic sarcoma.
Autorzy:: Huang H; Department of Medical Oncology and Radiation Sickness, Peking University Third Hospital, Beijing, China.
Zhang H; Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing, China.
Cao B; Department of Medical Oncology and Radiation Sickness, Peking University Third Hospital, Beijing, China.; Pokaż więcej
Źródło:: Thoracic cancer [Thorac Cancer] 2024 Feb; Vol. 15 (5), pp. 427-433. Date of Electronic Publication: 2024 Jan 11.
Typ publikacji:: Clinical Trial Protocol; Journal Article
MeSH Terms:: Antineoplastic Agents*/therapeutic use
Sarcoma*/drug therapy
Sarcoma*/pathology
Piperidines*
Pyridines*
Pyrimidines*
Humans ; Phosphatidylinositol 3-Kinases ; Clinical Trials, Phase I as Topic

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Skocz do pozycji: 31.

Tytuł:: 6-Amino-4-aryl-7-phenyl-3-(phenylimino)-4,7-dihydro-3H-[1,2]dithiolo[3,4-b]pyridine-5-carboxamides: Synthesis, Biological Activity, Quantum Chemical Studies and In Silico Docking Studies.
Autorzy:: Dotsenko VV; Department of Organic Chemistry and Technologies, Kuban State University, 149 Stavropolskaya St., 350040 Krasnodar, Russia.; Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, Russia.
Bespalov AV; Department of Organic Chemistry and Technologies, Kuban State University, 149 Stavropolskaya St., 350040 Krasnodar, Russia.
Sinotsko AE; Department of Organic Chemistry and Technologies, Kuban State University, 149 Stavropolskaya St., 350040 Krasnodar, Russia.
Temerdashev AZ; Department of Analytical Chemistry, Kuban State University, 149 Stavropolskaya St., 350040 Krasnodar, Russia.
Vasilin VK; Department of Bioorganic Chemistry, Kuban State Technological University, 2 Moskovskaya St., 350072 Krasnodar, Russia.
Varzieva EA; Department of Organic Chemistry and Technologies, Kuban State University, 149 Stavropolskaya St., 350040 Krasnodar, Russia.
Strelkov VD; Department of Organic Chemistry and Technologies, Kuban State University, 149 Stavropolskaya St., 350040 Krasnodar, Russia.
Aksenov NA; Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, Russia.
Aksenova IV; Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, Russia.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Jan 07; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 07.
Typ publikacji:: Journal Article
MeSH Terms:: Pyridines*
Aldehydes*
Molecular Docking Simulation ; Cyclization

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Skocz do pozycji: 32.

Tytuł:: The Impact of LY487379 or CDPPB on eNOS Expression in the Mouse Brain and the Effect of Joint Administration of Compounds with NO Releasers on MK-801- or Scopolamine-Driven Cognitive Dysfunction in Mice.
Autorzy:: Płoska A; Department of Medical Laboratory Diagnostics-Fahrenheit Biobank BBMRI.pl, Medical University of Gdansk, 7 Debinki Street, 80-211 Gdansk, Poland.
Siekierzycka A; Department of Medical Laboratory Diagnostics-Fahrenheit Biobank BBMRI.pl, Medical University of Gdansk, 7 Debinki Street, 80-211 Gdansk, Poland.
Cieślik P; Maj Institute of Pharmacology Polish Academy of Sciences, 12 Smetna Street, 31-343 Krakow, Poland.
Dobrucki LW; Department of Medical Laboratory Diagnostics-Fahrenheit Biobank BBMRI.pl, Medical University of Gdansk, 7 Debinki Street, 80-211 Gdansk, Poland.; Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.; Beckman Institute for Advanced Science and Technology, Urbana, IL 61801, USA.; Department of Biomedical and Translational Sciences, Carle-Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Kalinowski L; Department of Medical Laboratory Diagnostics-Fahrenheit Biobank BBMRI.pl, Medical University of Gdansk, 7 Debinki Street, 80-211 Gdansk, Poland.; BioTechMed Center, Department of Mechanics of Materials and Structures, Gdansk University of Technology, 11/12 Narutowicza Steet, 80-223 Gdansk, Poland.
Wierońska JM; Maj Institute of Pharmacology Polish Academy of Sciences, 12 Smetna Street, 31-343 Krakow, Poland.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2024 Jan 29; Vol. 29 (3). Date of Electronic Publication: 2024 Jan 29.
Typ publikacji:: Journal Article
MeSH Terms:: Dizocilpine Maleate*/pharmacology
Cognitive Dysfunction*/drug therapy
Nitroso Compounds*
Pyrazoles*
Benzamides*
Sulfonamides*
Pyridines*
Mice ; Animals ; Nitric Oxide/pharmacology ; Scopolamine/pharmacology ; Nitric Oxide Synthase Type III ; Brain ; Allosteric Regulation

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Skocz do pozycji: 33.

Tytuł:: Bioinformatics and Experimental Validation for Identifying Biomarkers Associated with AMG510 (Sotorasib) Resistance in KRAS -Mutated Lung Adenocarcinoma.
Autorzy:: Lin P; Key Laboratory of Marine Drugs, Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Cheng W; Key Laboratory of Marine Drugs, Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Qi X; Key Laboratory of Marine Drugs, Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Zhang P; Faculty of Information Science and Engineering, Ocean University of China, Qingdao 266003, China.
Xiong J; Faculty of Information Science and Engineering, Ocean University of China, Qingdao 266003, China.
Li J; Key Laboratory of Marine Drugs, Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Jan 26; Vol. 25 (3). Date of Electronic Publication: 2024 Jan 26.
Typ publikacji:: Journal Article
MeSH Terms:: Adenocarcinoma of Lung*/drug therapy
Adenocarcinoma of Lung*/genetics
Lung Neoplasms*/drug therapy
Lung Neoplasms*/genetics
F-Box Proteins*
Piperazines*
Pyridines*
Pyrimidines*
Humans ; Proto-Oncogene Proteins p21(ras) ; Computational Biology ; Biomarkers ; Mutation ; Transcription Factors ; Tumor Microenvironment/genetics ; Neoplasm Proteins

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Skocz do pozycji: 34.

Tytuł:: Identification of a Panel of miRNAs Associated with Resistance to Palbociclib and Endocrine Therapy.
Autorzy:: Torrisi R; Medical Oncology and Hematology Unit, Cancer Center, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milano, Italy.
Vaira V; Division of Pathology, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, 20122 Milano, Italy.; Department of Pathophysiology and Transplantation, University of Milan, 20122 Milano, Italy.
Giordano L; Biostatistic Unit, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milano, Italy.
Fernandes B; Pathology Department, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milano, Italy.
Saltalamacchia G; Medical Oncology and Hematology Unit, Cancer Center, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milano, Italy.
Palumbo R; Oncologia Medica IRCCS ICS Maugeri, 27100 Pavia, Italy.
Carnaghi C; Clinical Trials Unit, Istituto Clinico Humanitas, Centro Catanese di Oncologia, 20072 Catania, Italy.
Basilico V; Medical Oncology Unit, Istituto Clinico Mater Domini Humanitas, Castellanza, 21100 Varese, Italy.
Gentile F; Division of Pathology, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, 20122 Milano, Italy.
Masci G; Medical Oncology and Hematology Unit, Cancer Center, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milano, Italy.
De Sanctis R; Medical Oncology and Hematology Unit, Cancer Center, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milano, Italy.; Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, Italy.
Santoro A; Medical Oncology and Hematology Unit, Cancer Center, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milano, Italy.; Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, Italy.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Jan 25; Vol. 25 (3). Date of Electronic Publication: 2024 Jan 25.
Typ publikacji:: Journal Article
MeSH Terms:: MicroRNAs*/metabolism
Breast Neoplasms*/drug therapy
Breast Neoplasms*/genetics
Breast Neoplasms*/metabolism
Pyridines*
Humans ; Female ; Phosphatidylinositol 3-Kinases ; Piperazines/pharmacology ; Piperazines/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols ; Receptor, ErbB-2/metabolism ; Cyclin-Dependent Kinase 4/genetics

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Skocz do pozycji: 35.

Tytuł:: Glycogen Synthase Kinase-3 Inhibition by CHIR99021 Promotes Alveolar Epithelial Cell Proliferation and Lung Regeneration in the Lipopolysaccharide-Induced Acute Lung Injury Mouse Model.
Autorzy:: Fernandes R; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal.; ICVS/3B's-PT Government Associate Laboratory, 4806-909 Braga, Portugal.
Barbosa-Matos C; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal.; ICVS/3B's-PT Government Associate Laboratory, 4806-909 Braga, Portugal.
Borges-Pereira C; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal.; ICVS/3B's-PT Government Associate Laboratory, 4806-909 Braga, Portugal.
Carvalho ALRT; Department of Internal Medicine, São João Universitary Hospital Center, 4200-319 Porto, Portugal.; Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal.
Costa S; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal.; ICVS/3B's-PT Government Associate Laboratory, 4806-909 Braga, Portugal.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Jan 20; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 20.
Typ publikacji:: Journal Article
MeSH Terms:: Alveolar Epithelial Cells*
Acute Lung Injury*/chemically induced
Acute Lung Injury*/pathology
Pyridines*
Pyrimidines*
Animals ; Mice ; Lipopolysaccharides/pharmacology ; Glycogen Synthase Kinase 3 ; Lung/pathology ; Cell Proliferation

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Skocz do pozycji: 36.

Tytuł:: Investigation, scaffold hopping of novel donepezil-based compounds as anti-Alzhiemer's agents: synthesis, in-silico and pharmacological evaluations.
Autorzy:: Gupta M; Department of Pharmacy, Banasthali Vidyapith Newai, Banasthali, Rajasthan, India.
Pant S; Department of Pharmacy, Banasthali Vidyapith Newai, Banasthali, Rajasthan, India.
Rana P; Department of Medicinal Chemistry, National Institute for Pharmaceutical Education and Research (NIPER) Balangar, Hyderabad, India.
Kumar A; Department of Medical Affairs, Curie Sciences Pvt. Ltd., Samastipur, Bihar, 848125, India.
Prasun C; Department of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, 247667, India.
Nair MS; Department of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, 247667, India.
Paliwal S; Department of Pharmacy, Banasthali Vidyapith Newai, Banasthali, Rajasthan, India.
Nain S; Department of Pharmacy, Banasthali Vidyapith Newai, Banasthali, Rajasthan, India. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Jan 19; Vol. 14 (1), pp. 1687. Date of Electronic Publication: 2024 Jan 19.
Typ publikacji:: Journal Article
MeSH Terms:: Alzheimer Disease*/drug therapy
Quinolines*
Pyridines*
Sulfonamides*
Animals ; Donepezil/pharmacology ; Acetylcholinesterase/metabolism ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/chemistry ; Structure-Activity Relationship ; Quantitative Structure-Activity Relationship ; Pyrrolidinones ; Molecular Docking Simulation

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Skocz do pozycji: 37.

Tytuł:: Conformational diversity and protein-protein interfaces in drug repurposing in Ras signaling pathway.
Autorzy:: Sayin AZ; Department of Chemical and Biological Engineering, College of Engineering, Koc University, Rumeli Feneri Yolu Sariyer, 34450, Istanbul, Turkey.
Abali Z; Graduate School of Science and Engineering, Computational Sciences and Engineering, Koc University, 34450, Istanbul, Turkey.
Senyuz S; Graduate School of Science and Engineering, Computational Sciences and Engineering, Koc University, 34450, Istanbul, Turkey.
Cankara F; Graduate School of Science and Engineering, Computational Sciences and Engineering, Koc University, 34450, Istanbul, Turkey.
Gursoy A; Department of Computer Engineering, Koc University, 34450, Istanbul, Turkey.
Keskin O; Department of Chemical and Biological Engineering, College of Engineering, Koc University, Rumeli Feneri Yolu Sariyer, 34450, Istanbul, Turkey. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Jan 12; Vol. 14 (1), pp. 1239. Date of Electronic Publication: 2024 Jan 12.
Typ publikacji:: Journal Article
MeSH Terms:: Indinavir*
HIV Protease Inhibitors*
Pyridines*
Pyrones*
Sulfonamides*
Drug Repositioning ; Proteins/metabolism ; Signal Transduction ; ErbB Receptors/metabolism

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Tytuł:: Metabotropic glutamate receptor 5 (mGluR5) is associated with neurodegeneration and amyloid deposition in Alzheimer's disease: A [ F]PSS232 PET/MRI study.
Autorzy:: Wang J; Department of Nuclear Medicine &PET Center, Huashan Hospital, Fudan University, Shanghai, China.
He Y; Department of Chemistry and Applied Biosciences, Center for Radiopharmaceutical Sciences, Institute of Pharmaceutical Sciences, ETH Zurich, CH-8093, Zurich, Switzerland.
Chen X; Department of Nuclear Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Huang L; Department of Gerontology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China.
Li J; Department of Nuclear Medicine &PET Center, Huashan Hospital, Fudan University, Shanghai, China.
You Z; Department of Nuclear Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Huang Q; Department of Nuclear Medicine &PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Ren S; Department of Nuclear Medicine &PET Center, Huashan Hospital, Fudan University, Shanghai, China.
He K; Department of Nuclear Medicine &PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Schibli R; Department of Chemistry and Applied Biosciences, Center for Radiopharmaceutical Sciences, Institute of Pharmaceutical Sciences, ETH Zurich, CH-8093, Zurich, Switzerland.
Mu L; Department of Chemistry and Applied Biosciences, Center for Radiopharmaceutical Sciences, Institute of Pharmaceutical Sciences, ETH Zurich, CH-8093, Zurich, Switzerland.
Guan Y; Department of Nuclear Medicine &PET Center, Huashan Hospital, Fudan University, Shanghai, China. .
Guo Q; Department of Gerontology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China. .
Zhao J; Department of Nuclear Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China. .
Xie F; Department of Nuclear Medicine &PET Center, Huashan Hospital, Fudan University, Shanghai, China. .; Pokaż więcej
Źródło:: Alzheimer's research & therapy [Alzheimers Res Ther] 2024 Jan 12; Vol. 16 (1), pp. 9. Date of Electronic Publication: 2024 Jan 12.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Alzheimer Disease*/pathology
Cognitive Dysfunction*/metabolism
Oximes*
Pyridines*
Humans ; Amyloid beta-Peptides/metabolism ; Biomarkers/metabolism ; Brain/metabolism ; Glucose/metabolism ; Magnetic Resonance Imaging ; Positron-Emission Tomography ; Receptor, Metabotropic Glutamate 5/metabolism

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Tytuł:: Involvement of the tumour necrosis factor receptor system in glioblastoma cell death induced by palbociclib-heptamethine cyanine dye conjugate.
Autorzy:: Cooper E; Auckland Cancer Society Research Centre, School of Medical Sciences, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.; Department of Pharmacology, The Centre for Brain Research, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.; Neurosurgery Research Unit, The Centre for Brain Research, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.
Oyagawa CRM; Department of Pharmacology, The Centre for Brain Research, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.; Neurosurgery Research Unit, The Centre for Brain Research, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.
Johnson R; Department of Pharmacology, The Centre for Brain Research, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.; Neurosurgery Research Unit, The Centre for Brain Research, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.
Choi PJ; Auckland Cancer Society Research Centre, School of Medical Sciences, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.
Foliaki JM; Department of Pharmacology, The Centre for Brain Research, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.; Neurosurgery Research Unit, The Centre for Brain Research, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.
Correia J; Neurosurgery Research Unit, The Centre for Brain Research, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.; Department of Neurosurgery, Auckland City Hospital, Private Bag 92024, Auckland, 1142, New Zealand.
Schweder P; Neurosurgery Research Unit, The Centre for Brain Research, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.; Department of Neurosurgery, Auckland City Hospital, Private Bag 92024, Auckland, 1142, New Zealand.
Heppner P; Neurosurgery Research Unit, The Centre for Brain Research, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.; Department of Neurosurgery, Auckland City Hospital, Private Bag 92024, Auckland, 1142, New Zealand.
Mee E; Neurosurgery Research Unit, The Centre for Brain Research, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.; Department of Neurosurgery, Auckland City Hospital, Private Bag 92024, Auckland, 1142, New Zealand.
Turner C; Neurosurgery Research Unit, The Centre for Brain Research, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.; Department of Anatomical Pathology, Auckland City Hospital, 2 Park Road, LabPlus, Auckland, New Zealand.
Faull R; Neurosurgery Research Unit, The Centre for Brain Research, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.
Denny WA; Auckland Cancer Society Research Centre, School of Medical Sciences, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.
Dragunow M; Department of Pharmacology, The Centre for Brain Research, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand. .; Neurosurgery Research Unit, The Centre for Brain Research, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand. .
Jose J; Auckland Cancer Society Research Centre, School of Medical Sciences, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand. .
Park TI; Department of Pharmacology, The Centre for Brain Research, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand. .; Neurosurgery Research Unit, The Centre for Brain Research, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand. .; Pokaż więcej
Źródło:: Cell communication and signaling : CCS [Cell Commun Signal] 2024 Jan 11; Vol. 22 (1), pp. 30. Date of Electronic Publication: 2024 Jan 11.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms:: Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Carbocyanines*
Cytostatic Agents*/pharmacology
Cytostatic Agents*/therapeutic use
Glioblastoma*/drug therapy
Glioblastoma*/metabolism
Indoles*
Piperazines*
Pyridines*
Humans ; Apoptosis ; Cell Line, Tumor ; Receptors, Tumor Necrosis Factor/physiology ; Receptors, Tumor Necrosis Factor, Type I/metabolism ; Tumor Microenvironment ; Tumor Necrosis Factor-alpha/metabolism

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Tytuł:: Stratifying esophago-gastric cancer treatment using a patient-derived organoid-based threshold.
Autorzy:: Schmäche T; Department of Visceral, Thoracic and Vascular Surgery, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, Dresden, 01307, Germany.; National Center for Tumor Diseases Dresden (NCT/UCC), a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany.
Fohgrub J; Department of Visceral, Thoracic and Vascular Surgery, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, Dresden, 01307, Germany.; National Center for Tumor Diseases Dresden (NCT/UCC), a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany.
Klimova A; National Center for Tumor Diseases Dresden (NCT/UCC), a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany.; Institute for Medical Informatics and Biometry, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Laaber K; German Cancer Research Center (DKFZ) Heidelberg, Translational Functional Cancer Genomics, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.
Drukewitz S; National Center for Tumor Diseases Dresden (NCT/UCC), a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany.; Core Unit for Molecular Tumor Diagnostics (CMTD), Technical University Dresden, Dresden, Germany.; Institute of Human Genetics, University of Leipzig Medical Center, Leipzig, Germany.
Merboth F; Department of Visceral, Thoracic and Vascular Surgery, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, Dresden, 01307, Germany.
Hennig A; Department of Visceral, Thoracic and Vascular Surgery, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, Dresden, 01307, Germany.; National Center for Tumor Diseases Dresden (NCT/UCC), a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany.
Seidlitz T; Department of Visceral, Thoracic and Vascular Surgery, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, Dresden, 01307, Germany.
Herbst F; German Cancer Research Center (DKFZ) Heidelberg, Translational Functional Cancer Genomics, Heidelberg, Germany.; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Baenke F; Department of Visceral, Thoracic and Vascular Surgery, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, Dresden, 01307, Germany.
Ada AM; Department of Visceral, Thoracic and Vascular Surgery, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, Dresden, 01307, Germany.
Groß T; National Center for Tumor Diseases Dresden (NCT/UCC), a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany.; Core Unit for Molecular Tumor Diagnostics (CMTD), Technical University Dresden, Dresden, Germany.; German Cancer Consortium (DKTK), Dresden, Germany.
Wenzel C; Institute of Pathology, University Hospital Carl Gustav CarusTechnische Universität Dresden, Dresden, Germany.
Ball CR; National Center for Tumor Diseases Dresden (NCT/UCC), a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany.; Department for Translational Medical Oncology, National Center for Tumor Diseases Dresden (NCT/UCC), Dresden, Germany.; Translational Medical Oncology, Faculty of Medicine and University Hospital Carl Gustav CarusTechnische Universität Dresden, Dresden, Germany.; German Cancer Consortium (DKTK), partner side Dresden, Dresden, Germany.; TUD Dresden University of Technology, Faculty of Biology, Technische Universität Dresden, Dresden, Germany.
Praetorius C; Department of Visceral, Thoracic and Vascular Surgery, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, Dresden, 01307, Germany.; National Center for Tumor Diseases Dresden (NCT/UCC), a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany.
Schmidt T; Department of General, Visceral and Transplantation Surgery, University Hospital of Heidelberg, Heidelberg, Germany.; Department of General, Visceral, Cancer and Transplantation Surgery, University Hospital of Cologne, Cologne, Germany.
Ringelband-Schilling B; Department of Visceral, Thoracic and Vascular Surgery, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, Dresden, 01307, Germany.
Koschny R; Department of Gastroenterology and Hepatology, University Hospital of Heidelberg, Heidelberg, Germany.
Stenzinger A; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.
Roeder I; National Center for Tumor Diseases Dresden (NCT/UCC), a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany.; Institute for Medical Informatics and Biometry, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Jaeger D; Department of Medical Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Applied Tumor-Immunity, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Zeissig S; Department of Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany.; Center for Regenerative Therapies (CRTD), Technische Universität Dresden, Dresden, Germany.
Welsch T; Department of Visceral, Thoracic and Vascular Surgery, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, Dresden, 01307, Germany.; Department of General, Visceral, and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Aust D; Institute of Pathology, University Hospital Carl Gustav CarusTechnische Universität Dresden, Dresden, Germany.; Tumour- and Normal Tissue Bank of the University Cancer Center (UCC), University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Dresden, Germany.
Glimm H; National Center for Tumor Diseases Dresden (NCT/UCC), a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany.; German Cancer Research Center (DKFZ) Heidelberg, Translational Functional Cancer Genomics, Heidelberg, Germany.; Department for Translational Medical Oncology, National Center for Tumor Diseases Dresden (NCT/UCC), Dresden, Germany.; Translational Medical Oncology, Faculty of Medicine and University Hospital Carl Gustav CarusTechnische Universität Dresden, Dresden, Germany.; German Cancer Consortium (DKTK), partner side Dresden, Dresden, Germany.
Folprecht G; National Center for Tumor Diseases Dresden (NCT/UCC), a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany.; Department of Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany.
Weitz J; Department of Visceral, Thoracic and Vascular Surgery, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, Dresden, 01307, Germany.; National Center for Tumor Diseases Dresden (NCT/UCC), a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany.
Haag GM; Department of Medical Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Applied Tumor-Immunity, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Stange DE; Department of Visceral, Thoracic and Vascular Surgery, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, Dresden, 01307, Germany. .; National Center for Tumor Diseases Dresden (NCT/UCC), a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany. .; Pokaż więcej
Źródło:: Molecular cancer [Mol Cancer] 2024 Jan 10; Vol. 23 (1), pp. 10. Date of Electronic Publication: 2024 Jan 10.
Typ publikacji:: Letter; Research Support, Non-U.S. Gov't
MeSH Terms:: Stomach Neoplasms*/drug therapy
Adenocarcinoma*/drug therapy
Carbamates*
Pyrazines*
Pyridines*
Humans ; Combined Modality Therapy ; Neoadjuvant Therapy ; Organoids ; Fluorouracil/pharmacology

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