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Tytuł:
Decreased Human Platelet Activation and Mouse Pulmonary Thrombosis by Rutaecarpine and Comparison of the Relative Effectiveness with BAY11-7082: Crucial Signals of p38-NF-κB.
Autorzy:
Huang WC; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Hou SM; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.; Department of Cardiovascular Center, Cathay General Hospital, Taipei 106, Taiwan.; School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan.
Wu MP; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.; Division of Urogynecology, Department of Obstetrics and Gynecology, Chi Mei Medical Center, Tainan 710, Taiwan.
Hsia CW; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Jayakumar T; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Hsia CH; Translational Medicine Center, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 111, Taiwan.
Bhavan PS; Department of Zoology, Bharathiar University, Coimbatore 641046, Tamil Nadu, India.
Chung CL; Department of Internal Medicine, Division of Pulmonary Medicine, Taipei Medical University Hospital, Taipei 110, Taiwan.; School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Sheu JR; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Jan 12; Vol. 27 (2). Date of Electronic Publication: 2022 Jan 12.
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
Fibrinolytic Agents/*pharmacology
Indole Alkaloids/*pharmacology
NF-kappa B/*metabolism
Nitriles/*pharmacology
Quinazolines/*pharmacology
Sulfones/*pharmacology
Thrombosis/*drug therapy
Thrombosis/*metabolism
p38 Mitogen-Activated Protein Kinases/*metabolism
Animals ; Disease Models, Animal ; Fibrinolytic Agents/therapeutic use ; Free Radical Scavengers/pharmacology ; Free Radical Scavengers/therapeutic use ; Free Radicals/antagonists & inhibitors ; Humans ; I-kappa B Kinase/antagonists & inhibitors ; Imidazoles/pharmacology ; Imidazoles/therapeutic use ; Indole Alkaloids/therapeutic use ; Male ; Mice, Inbred ICR ; NF-kappa B/antagonists & inhibitors ; Nitriles/therapeutic use ; P-Selectin/metabolism ; Platelet Activation/drug effects ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Pulmonary Embolism/drug therapy ; Pulmonary Embolism/metabolism ; Pyridines/pharmacology ; Pyridines/therapeutic use ; Quinazolines/therapeutic use ; Sulfones/therapeutic use ; Transcription Factor RelA/metabolism ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Genome-wide gene expression analysis of a murine model of prostate cancer progression: Deciphering the roles of IL-6 and p38 MAPK as potential therapeutic targets.
Autorzy:
Daouk R; Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Bahmad HF; Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.; Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL, United States of America.; Herbert Wertheim College of Medicine, Florida International University, Miami, FL, United States of America.
Saleh E; Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Monzer A; Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Ballout F; Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Kadara H; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America.
Abou-Kheir W; Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
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Źródło:
PloS one [PLoS One] 2020 Aug 13; Vol. 15 (8), pp. e0237442. Date of Electronic Publication: 2020 Aug 13 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation, Neoplastic/*drug effects
Imidazoles/*pharmacology
Interleukin-6/*pharmacology
Prostatic Neoplasms/*pathology
Pyridines/*pharmacology
p38 Mitogen-Activated Protein Kinases/*antagonists & inhibitors
Androgens/metabolism ; Animals ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Disease Models, Animal ; Disease Progression ; Epithelial-Mesenchymal Transition/drug effects ; Gene Regulatory Networks/genetics ; Imidazoles/therapeutic use ; Interleukin-6/therapeutic use ; Male ; Mice ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/metabolism ; Pyridines/therapeutic use ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's disease.
Autorzy:
Chen J; Department of Occupational Health and Occupational Medicine, Guangdong Province Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1838, North Guangzhou Road, Guangzhou, 510515, Guangdong Province, China.; School of Public Health, Guangdong Medical University, Dongguan,, Guangdong Province, China.
Mao K; Department of Occupational Health and Occupational Medicine, Guangdong Province Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1838, North Guangzhou Road, Guangzhou, 510515, Guangdong Province, China.
Yu H; Department of Occupational Health and Occupational Medicine, Guangdong Province Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1838, North Guangzhou Road, Guangzhou, 510515, Guangdong Province, China.
Wen Y; Department of Occupational Health and Occupational Medicine, Guangdong Province Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1838, North Guangzhou Road, Guangzhou, 510515, Guangdong Province, China.
She H; Department of Pharmacology, Emory University School of Medicine, Atlanta, GA, USA.
Zhang H; School of Public Health, Guangdong Medical University, Dongguan,, Guangdong Province, China.
Liu L; School of Public Health, Guangdong Medical University, Dongguan,, Guangdong Province, China.
Li M; School of Public Health, Guangdong Medical University, Dongguan,, Guangdong Province, China.
Li W; Department of Occupational Health and Occupational Medicine, Guangdong Province Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1838, North Guangzhou Road, Guangzhou, 510515, Guangdong Province, China. .
Zou F; Department of Occupational Health and Occupational Medicine, Guangdong Province Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1838, North Guangzhou Road, Guangzhou, 510515, Guangdong Province, China. .
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Źródło:
Journal of neuroinflammation [J Neuroinflammation] 2021 Dec 20; Vol. 18 (1), pp. 295. Date of Electronic Publication: 2021 Dec 20.
Typ publikacji:
Journal Article
MeSH Terms:
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/*metabolism
Chaperone-Mediated Autophagy/*physiology
Microglia/*metabolism
NLR Family, Pyrin Domain-Containing 3 Protein/*metabolism
Parkinson Disease/*metabolism
p38 Mitogen-Activated Protein Kinases/*metabolism
Animals ; Chaperone-Mediated Autophagy/drug effects ; Imidazoles/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Microglia/drug effects ; NLR Family, Pyrin Domain-Containing 3 Protein/antagonists & inhibitors ; Parkinson Disease/genetics ; Proteolysis/drug effects ; Pyridines/pharmacology ; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
SB203580-A Potent p38 MAPK Inhibitor Reduces the Profibrotic Bronchial Fibroblasts Transition Associated with Asthma.
Autorzy:
Paw M; Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Kraków, Poland.
Wnuk D; Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Kraków, Poland.
Nit K; Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Kraków, Poland.
Bobis-Wozowicz S; Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Kraków, Poland.
Szychowski R; Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Kraków, Poland.
Ślusarczyk A; Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Kraków, Poland.
Madeja Z; Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Kraków, Poland.
Michalik M; Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Kraków, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Nov 26; Vol. 22 (23). Date of Electronic Publication: 2021 Nov 26.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Differentiation*
Asthma/*drug therapy
Bronchi/*drug effects
Enzyme Inhibitors/*pharmacology
Fibroblasts/*drug effects
Imidazoles/*pharmacology
Pyridines/*pharmacology
p38 Mitogen-Activated Protein Kinases/*antagonists & inhibitors
Adult ; Asthma/enzymology ; Asthma/pathology ; Bronchi/enzymology ; Cells, Cultured ; Female ; Fibroblasts/enzymology ; Humans ; Male ; Middle Aged ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Osteocrin ameliorates adriamycin nephropathy via p38 mitogen-activated protein kinase inhibition.
Autorzy:
Handa T; Department of Nephrology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, Kyoto, 6068507, Japan.
Mori KP; Department of Nephrology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, Kyoto, 6068507, Japan.; Department of Nephrology and Dialysis, Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka, Japan.; TMK Project, Medical Innovation Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Ishii A; Department of Nephrology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, Kyoto, 6068507, Japan.
Ohno S; Department of Nephrology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, Kyoto, 6068507, Japan.
Kanai Y; Department of Diabetes Mellitus and Endocrinology, Osaka Red Cross Hospital, Osaka, Japan.
Watanabe-Takano H; Department of Cell Biology, National Cerebral and Cardiovascular Center, Research Institute, Suita, Japan.
Yasoda A; Clinical Research Center, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Kuwabara T; Department of Nephrology, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.
Takahashi N; Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan.
Mochizuki N; Department of Cell Biology, National Cerebral and Cardiovascular Center, Research Institute, Suita, Japan.
Mukoyama M; Department of Nephrology, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.
Yanagita M; Department of Nephrology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, Kyoto, 6068507, Japan.; Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan.
Yokoi H; Department of Nephrology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, Kyoto, 6068507, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2021 Nov 08; Vol. 11 (1), pp. 21835. Date of Electronic Publication: 2021 Nov 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Kidney Diseases/*metabolism
Muscle Proteins/*metabolism
Transcription Factors/*metabolism
p38 Mitogen-Activated Protein Kinases/*antagonists & inhibitors
Animals ; Disease Models, Animal ; Doxorubicin/toxicity ; Kidney Diseases/chemically induced ; Kidney Diseases/pathology ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Muscle Proteins/deficiency ; Muscle Proteins/genetics ; Podocytes/drug effects ; Podocytes/metabolism ; Podocytes/pathology ; Protein Kinase Inhibitors/pharmacology ; Pyrazoles/pharmacology ; Pyridines/pharmacology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptors, Atrial Natriuretic Factor/metabolism ; Signal Transduction/drug effects ; Transcription Factors/deficiency ; Transcription Factors/genetics ; Up-Regulation ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Protective effect of taurine on sepsis‑induced lung injury via inhibiting the p38/MAPK signaling pathway.
Autorzy:
Chen J; Department of Critical Care Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu 211100, P.R. China.
Xue X; Department of Critical Care Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu 211100, P.R. China.
Cai J; Department of Critical Care Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu 211100, P.R. China.
Jia L; Department of Critical Care Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu 211100, P.R. China.
Sun B; Department of Emergency Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu 211100, P.R. China.
Zhao W; Department of Critical Care Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu 211100, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2021 Sep; Vol. 24 (3). Date of Electronic Publication: 2021 Jul 19.
Typ publikacji:
Journal Article
MeSH Terms:
Acute Lung Injury/*drug therapy
MAP Kinase Signaling System/*drug effects
Sepsis/*complications
Signal Transduction/*drug effects
Taurine/*pharmacology
p38 Mitogen-Activated Protein Kinases/*metabolism
Acute Lung Injury/etiology ; Acute Lung Injury/pathology ; Animals ; Disease Models, Animal ; Imidazoles/pharmacology ; Lung/metabolism ; Male ; Malondialdehyde/metabolism ; NF-kappa B/metabolism ; Oxidative Stress/drug effects ; Pyridines/pharmacology ; Rats ; Rats, Sprague-Dawley ; Tumor Necrosis Factor-alpha
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Oleic acid induces A7r5 cell proliferation and migration associated with increased expression of HGF and p‑p38.
Autorzy:
Li J; Department of Clinical Medicine, Jishou University School of Medicine, Jishou, Hunan 416000, P.R. China.
Chu T; Department of Nursing, Jishou University School of Medicine, Jishou, Hunan 416000, P.R. China.
Yang M; Laboratory of Disorders Genes and Department of Pharmacology, Jishou University School of Pharmacy, Jishou, Hunan 416000, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2021 Jul; Vol. 24 (1). Date of Electronic Publication: 2021 Apr 28.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Movement/*drug effects
Cell Proliferation/*drug effects
Hepatocyte Growth Factor/*metabolism
Oleic Acid/*pharmacology
p38 Mitogen-Activated Protein Kinases/*metabolism
Animals ; Cell Line ; Hepatocyte Growth Factor/genetics ; Humans ; Imidazoles ; Indoles/pharmacology ; Myocytes, Smooth Muscle/metabolism ; Phosphorylation ; Pyridines ; Signal Transduction ; Sulfones/pharmacology ; p38 Mitogen-Activated Protein Kinases/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Inhibition of p38 Mitogen-Activated Protein Kinase Impairs Mayaro Virus Replication in Human Dermal Fibroblasts and HeLa Cells.
Autorzy:
Sugasti-Salazar M; Grupo de Biología Celular y Molecular de Arbovirus, Instituto Conmemorativo Gorgas de Estudios de la Salud, Panamá 0816-02593, Panama.; Programa de Maestría en Microbiología Ambiental, Universidad de Panamá, Panamá 0824, Panama.
Llamas-González YY; Grupo de Biología Celular y Molecular de Arbovirus, Instituto Conmemorativo Gorgas de Estudios de la Salud, Panamá 0816-02593, Panama.; Programa de Doctorado en Ciencias Biológicas, Universidad de la República, Montevideo 11200, Uruguay.
Campos D; Grupo de Biología Celular y Molecular de Arbovirus, Instituto Conmemorativo Gorgas de Estudios de la Salud, Panamá 0816-02593, Panama.
González-Santamaría J; Grupo de Biología Celular y Molecular de Arbovirus, Instituto Conmemorativo Gorgas de Estudios de la Salud, Panamá 0816-02593, Panama.
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Źródło:
Viruses [Viruses] 2021 Jun 17; Vol. 13 (6). Date of Electronic Publication: 2021 Jun 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alphavirus/*physiology
Fibroblasts/*virology
Virus Replication/*genetics
p38 Mitogen-Activated Protein Kinases/*antagonists & inhibitors
p38 Mitogen-Activated Protein Kinases/*genetics
Apoptosis ; Cells, Cultured ; Cyclopropanes/pharmacology ; Fibroblasts/drug effects ; Fibroblasts/pathology ; HeLa Cells ; Host Microbial Interactions/drug effects ; Humans ; Imidazoles/pharmacology ; MAP Kinase Signaling System ; Phosphorylation ; Pyridines/pharmacology ; Skin/cytology ; Skin/virology ; Virus Replication/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
RNA-seq Characterization of Melanoma Phenotype Switch in 3D Collagen after p38 MAPK Inhibitor Treatment.
Autorzy:
Čermák V; Department of Cell Biology, Charles University, Viničná 7, 128 44 Prague, Czech Republic.; Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University (BIOCEV), Průmyslová 595, 252 42 Vestec u Prahy, Czech Republic.
Škarková A; Department of Cell Biology, Charles University, Viničná 7, 128 44 Prague, Czech Republic.; Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University (BIOCEV), Průmyslová 595, 252 42 Vestec u Prahy, Czech Republic.
Merta L; Department of Cell Biology, Charles University, Viničná 7, 128 44 Prague, Czech Republic.; Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University (BIOCEV), Průmyslová 595, 252 42 Vestec u Prahy, Czech Republic.
Kolomazníková V; Department of Cell Biology, Charles University, Viničná 7, 128 44 Prague, Czech Republic.; Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University (BIOCEV), Průmyslová 595, 252 42 Vestec u Prahy, Czech Republic.
Palušová V; Department of Biology, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.; International Clinical Research Center, St. Anne's University Hospital, Pekařská 53, 656 91 Brno, Czech Republic.
Uldrijan S; Department of Biology, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.; International Clinical Research Center, St. Anne's University Hospital, Pekařská 53, 656 91 Brno, Czech Republic.
Rösel D; Department of Cell Biology, Charles University, Viničná 7, 128 44 Prague, Czech Republic.; Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University (BIOCEV), Průmyslová 595, 252 42 Vestec u Prahy, Czech Republic.
Brábek J; Department of Cell Biology, Charles University, Viničná 7, 128 44 Prague, Czech Republic.; Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University (BIOCEV), Průmyslová 595, 252 42 Vestec u Prahy, Czech Republic.
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Źródło:
Biomolecules [Biomolecules] 2021 Mar 17; Vol. 11 (3). Date of Electronic Publication: 2021 Mar 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Collagen/*metabolism
Melanoma/*genetics
Protein Kinase Inhibitors/*pharmacology
RNA-Seq/*methods
Tumor Microenvironment/*drug effects
p38 Mitogen-Activated Protein Kinases/*antagonists & inhibitors
Cell Differentiation/drug effects ; Cell Differentiation/genetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Gene Expression Profiling/methods ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Ontology ; Humans ; Imidazoles/pharmacology ; Melanoma/pathology ; Naphthalenes/pharmacology ; Phenotype ; Pyrazoles/pharmacology ; Pyridines/pharmacology ; Reverse Transcriptase Polymerase Chain Reaction ; Tumor Microenvironment/genetics ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
P38 Inhibition Prevents Herpes Simplex Virus Type 1 (HSV-1) Infection in Cultured Corneal Keratocytes.
Autorzy:
Xian-Kui H; Department of Ophthalmology, Shijiazhuang Aier Eye Hospital , Shijiazhuang, China.
Hui-Fang W; Department of Ophthalmology, Shijiazhuang Aier Eye Hospital , Shijiazhuang, China.
Jing-Ran S; Department of Ophthalmology, Shijiazhuang Aier Eye Hospital , Shijiazhuang, China.
Yu-Rong H; Department of Ophthalmology, Shijiazhuang Aier Eye Hospital , Shijiazhuang, China.
Bo-Yu C; Department of Ophthalmology, Shijiazhuang Aier Eye Hospital , Shijiazhuang, China.
Xiu-Jun S; Department of Ophthalmology, Shijiazhuang Aier Eye Hospital , Shijiazhuang, China.
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Źródło:
Current eye research [Curr Eye Res] 2020 Nov; Vol. 45 (11), pp. 1342-1351. Date of Electronic Publication: 2020 Apr 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Corneal Keratocytes/*drug effects
Herpes Simplex/*prevention & control
Herpesvirus 1, Human/*physiology
Imidazoles/*pharmacology
Pyridines/*pharmacology
p38 Mitogen-Activated Protein Kinases/*antagonists & inhibitors
Actins/genetics ; Actins/metabolism ; Aldehyde Dehydrogenase 1 Family/genetics ; Aldehyde Dehydrogenase 1 Family/metabolism ; Animals ; Blotting, Western ; Cell Survival ; Cells, Cultured ; Chlorocebus aethiops ; Corneal Keratocytes/virology ; Cytokines/metabolism ; DNA Copy Number Variations ; Dose-Response Relationship, Drug ; Enzyme-Linked Immunosorbent Assay ; Herpes Simplex/metabolism ; Herpes Simplex/virology ; Humans ; Interferon Regulatory Factor-3/genetics ; Interferon Regulatory Factor-3/metabolism ; Microscopy, Fluorescence ; Real-Time Polymerase Chain Reaction ; Retinal Dehydrogenase/genetics ; Retinal Dehydrogenase/metabolism ; Time Factors ; Vero Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
SB203580 protects against inflammatory response and lung injury in a mouse model of lipopolysaccharide‑induced acute lung injury.
Autorzy:
Li G; Center of Clinical Research, Wuxi People's Hospital of Nanjing Medical University, Wuxi, Jiangsu 214023, P.R. China.
Dai Y; Center of Clinical Research, Wuxi People's Hospital of Nanjing Medical University, Wuxi, Jiangsu 214023, P.R. China.
Tan J; Center of Clinical Research, Wuxi People's Hospital of Nanjing Medical University, Wuxi, Jiangsu 214023, P.R. China.
Zou J; Center of Clinical Research, Wuxi People's Hospital of Nanjing Medical University, Wuxi, Jiangsu 214023, P.R. China.
Nie X; Center of Clinical Research, Wuxi People's Hospital of Nanjing Medical University, Wuxi, Jiangsu 214023, P.R. China.
Yang Z; Center of Clinical Research, Wuxi People's Hospital of Nanjing Medical University, Wuxi, Jiangsu 214023, P.R. China.
Zhao J; Center of Clinical Research, Wuxi People's Hospital of Nanjing Medical University, Wuxi, Jiangsu 214023, P.R. China.
Yang X; Center of Clinical Research, Wuxi People's Hospital of Nanjing Medical University, Wuxi, Jiangsu 214023, P.R. China.
Chen J; Center of Clinical Research, Wuxi People's Hospital of Nanjing Medical University, Wuxi, Jiangsu 214023, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2020 Aug; Vol. 22 (2), pp. 1656-1662. Date of Electronic Publication: 2020 Jun 04.
Typ publikacji:
Journal Article
MeSH Terms:
Acute Lung Injury/*drug therapy
Imidazoles/*therapeutic use
Interferon Regulatory Factors/*metabolism
Nitric Oxide Synthase Type II/*metabolism
Protein Kinase Inhibitors/*therapeutic use
Pyridines/*therapeutic use
p38 Mitogen-Activated Protein Kinases/*antagonists & inhibitors
Acute Lung Injury/chemically induced ; Animals ; Cytokines/metabolism ; Disease Models, Animal ; Gene Expression/drug effects ; Lipopolysaccharides ; Male ; Mice ; Mice, Inbred C57BL
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Activation of GPR40 induces hypothalamic neurogenesis through p38- and BDNF-dependent mechanisms.
Autorzy:
Engel DF; Laboratory of Cell Signaling and Obesity and Comorbidities Research Center, University of Campinas, Campinas, SP, 13084-970, Brazil. .
Bobbo VCD; Laboratory of Cell Signaling and Obesity and Comorbidities Research Center, University of Campinas, Campinas, SP, 13084-970, Brazil.
Solon CS; Laboratory of Cell Signaling and Obesity and Comorbidities Research Center, University of Campinas, Campinas, SP, 13084-970, Brazil.
Nogueira GA; Laboratory of Cell Signaling and Obesity and Comorbidities Research Center, University of Campinas, Campinas, SP, 13084-970, Brazil.
Moura-Assis A; Laboratory of Cell Signaling and Obesity and Comorbidities Research Center, University of Campinas, Campinas, SP, 13084-970, Brazil.
Mendes NF; Laboratory of Cell Signaling and Obesity and Comorbidities Research Center, University of Campinas, Campinas, SP, 13084-970, Brazil.
Zanesco AM; Laboratory of Cell Signaling and Obesity and Comorbidities Research Center, University of Campinas, Campinas, SP, 13084-970, Brazil.
Papangelis A; Department of Drug Design and Pharmacology, University of Copenhagen, 2100, Copenhagen, Denmark.
Ulven T; Department of Drug Design and Pharmacology, University of Copenhagen, 2100, Copenhagen, Denmark.
Velloso LA; Laboratory of Cell Signaling and Obesity and Comorbidities Research Center, University of Campinas, Campinas, SP, 13084-970, Brazil. .
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Źródło:
Scientific reports [Sci Rep] 2020 Jul 06; Vol. 10 (1), pp. 11047. Date of Electronic Publication: 2020 Jul 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Brain-Derived Neurotrophic Factor/*physiology
Hypothalamus/*cytology
Hypothalamus/*physiology
Neurogenesis/*physiology
Receptors, G-Protein-Coupled/*physiology
p38 Mitogen-Activated Protein Kinases/*physiology
Animals ; Cell Line ; Cell Proliferation/drug effects ; Cell Proliferation/physiology ; Cell Survival/drug effects ; Cell Survival/physiology ; Hypothalamus/drug effects ; Imidazoles/pharmacology ; Interleukin-6/physiology ; Ligands ; Male ; Methylamines/pharmacology ; Mice ; Mice, Inbred C57BL ; Models, Neurological ; Neurons/drug effects ; Neurons/physiology ; Propionates/pharmacology ; Protein Kinase Inhibitors/pharmacology ; Pyridines/pharmacology ; Receptors, G-Protein-Coupled/agonists ; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors
Czasopismo naukowe
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Tytuł:
Inhibition of spinal p38 MAPK prevents articular neutrophil infiltration in experimental arthritis via sympathetic activation.
Autorzy:
Kanashiro A; Department of Physiological Sciences, Federal University of São Carlos (UFSCAR), Rod. Washington Luis, km 235, São Carlos, SP, 13565-905, Brazil.; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Bandeirantes Av. 3900, Ribeirao Preto, SP, 140490-900, Brazil.
Franchin M; Department of Physiological Sciences, Piracicaba Dental School, University of Campinas, Limeira Av, 901, Piracicaba, SP, 13414-903, Brazil.
Bassi GS; Department of Immunology, Ribeirão Preto Medical School, University of São Paulo, Bandeirantes Av. 3900, Ribeirao Preto, SP, 140490-900, Brazil.; Translational Research Center for GastroIntestinal Disorders (TARGID), Intestinal Neuroimmune Interactions, University of Leuven, 3000, Leuven, Belgium.
Reis Santana DA; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Bandeirantes Av. 3900, Ribeirao Preto, SP, 140490-900, Brazil.
Cunha TM; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Bandeirantes Av. 3900, Ribeirao Preto, SP, 140490-900, Brazil.
Cunha FQ; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Bandeirantes Av. 3900, Ribeirao Preto, SP, 140490-900, Brazil.
Ulloa L; Department of Surgery, Center of Immunology and Inflammation, Rutgers - New Jersey Medical School, Rutgers University, Newark, NJ, 07103, USA.
Rodrigues GJ; Department of Physiological Sciences, Federal University of São Carlos (UFSCAR), Rod. Washington Luis, km 235, São Carlos, SP, 13565-905, Brazil.
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Źródło:
Fundamental & clinical pharmacology [Fundam Clin Pharmacol] 2018 Apr; Vol. 32 (2), pp. 155-162. Date of Electronic Publication: 2017 Dec 22.
Typ publikacji:
Journal Article
MeSH Terms:
Anti-Inflammatory Agents/*pharmacology
Arthritis, Experimental/*prevention & control
Imidazoles/*pharmacology
Joints/*drug effects
Neutrophil Infiltration/*drug effects
Protein Kinase Inhibitors/*pharmacology
Pyridines/*pharmacology
Spinal Cord/*drug effects
Sympathetic Nervous System/*drug effects
p38 Mitogen-Activated Protein Kinases/*antagonists & inhibitors
Animals ; Anti-Inflammatory Agents/administration & dosage ; Arthritis, Experimental/enzymology ; Arthritis, Experimental/immunology ; Arthritis, Experimental/physiopathology ; Dose-Response Relationship, Drug ; Imidazoles/administration & dosage ; Injections, Spinal ; Joints/immunology ; Joints/innervation ; Male ; Mice, Inbred BALB C ; Protein Kinase Inhibitors/administration & dosage ; Pyridines/administration & dosage ; Receptors, Adrenergic, beta/metabolism ; Signal Transduction/drug effects ; Spinal Cord/enzymology ; Spinal Cord/physiopathology ; Sympathetic Nervous System/metabolism ; Sympathetic Nervous System/physiopathology ; Time Factors ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
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Tytuł:
Protein Kinase A Is Involved in Neuropathic Pain by Activating the p38MAPK Pathway to Mediate Spinal Cord Cell Apoptosis.
Autorzy:
Deng Y; Department of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu Province 730030, China.; Key Laboratory of Orthopaedics Disease of Gansu Province, Lanzhou University Second Hospital, Lanzhou, Gansu Province 730030, China.; The International Cooperation Base of Gansu Province for The Pain Research in Spinal Disorders, Lanzhou, Gansu Province 730030, China.
Yang L; Department of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu Province 730030, China.; Key Laboratory of Orthopaedics Disease of Gansu Province, Lanzhou University Second Hospital, Lanzhou, Gansu Province 730030, China.; The International Cooperation Base of Gansu Province for The Pain Research in Spinal Disorders, Lanzhou, Gansu Province 730030, China.
Xie Q; Department of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu Province 730030, China.; Key Laboratory of Orthopaedics Disease of Gansu Province, Lanzhou University Second Hospital, Lanzhou, Gansu Province 730030, China.; The International Cooperation Base of Gansu Province for The Pain Research in Spinal Disorders, Lanzhou, Gansu Province 730030, China.
Yang F; Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou, Gansu Province 730030, China.; Institute of Neurology of Gansu Province, Lanzhou University Second Hospital, Lanzhou, Gansu Province 730030, China.
Li G; Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou, Gansu Province 730030, China.; Institute of Neurology of Gansu Province, Lanzhou University Second Hospital, Lanzhou, Gansu Province 730030, China.
Zhang G; Department of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu Province 730030, China.; Key Laboratory of Orthopaedics Disease of Gansu Province, Lanzhou University Second Hospital, Lanzhou, Gansu Province 730030, China.; The International Cooperation Base of Gansu Province for The Pain Research in Spinal Disorders, Lanzhou, Gansu Province 730030, China.
Li S; Department of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu Province 730030, China.; Key Laboratory of Orthopaedics Disease of Gansu Province, Lanzhou University Second Hospital, Lanzhou, Gansu Province 730030, China.
Wu Z; Department of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu Province 730030, China.; Key Laboratory of Orthopaedics Disease of Gansu Province, Lanzhou University Second Hospital, Lanzhou, Gansu Province 730030, China.
Wang J; The Department of Osteoporosis, The People's Hospital of Baoan District, Shenzhen, Guangdong Province 518000, China.
Kang X; Department of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu Province 730030, China.; Key Laboratory of Orthopaedics Disease of Gansu Province, Lanzhou University Second Hospital, Lanzhou, Gansu Province 730030, China.; The International Cooperation Base of Gansu Province for The Pain Research in Spinal Disorders, Lanzhou, Gansu Province 730030, China.
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Źródło:
Mediators of inflammation [Mediators Inflamm] 2020 Mar 23; Vol. 2020, pp. 6420425. Date of Electronic Publication: 2020 Mar 23 (Print Publication: 2020).
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*physiology
Cyclic AMP-Dependent Protein Kinases/*metabolism
Neuralgia/*metabolism
Neuralgia/*pathology
p38 Mitogen-Activated Protein Kinases/*metabolism
p38 Mitogen-Activated Protein Kinases/*physiology
Animals ; Apoptosis/genetics ; Blotting, Western ; Cyclic AMP-Dependent Protein Kinases/genetics ; Enzyme-Linked Immunosorbent Assay ; Imidazoles/pharmacology ; Immunohistochemistry ; In Situ Nick-End Labeling ; Male ; Pyridines/pharmacology ; Rats ; Software ; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors
Czasopismo naukowe
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Tytuł:
Plastin 3 down-regulation augments the sensitivity of MDA-MB-231 cells to paclitaxel via the p38 MAPK signalling pathway.
Autorzy:
Ma Y; a CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety , CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China , Beijing , China.
Lai W; a CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety , CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China , Beijing , China.
Zhao M; a CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety , CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China , Beijing , China.
Yue C; a CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety , CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China , Beijing , China.; b Sino-Danish College , University of Chinese Academy of Sciences , Beijing , China.
Shi F; a CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety , CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China , Beijing , China.; b Sino-Danish College , University of Chinese Academy of Sciences , Beijing , China.
Li R; a CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety , CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China , Beijing , China.; c Academy for Advanced Interdisciplinary Studies , Peking University , Beijing , China.; d University of Chinese Academy of Sciences , Beijing , China.
Hu Z; a CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety , CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China , Beijing , China.; b Sino-Danish College , University of Chinese Academy of Sciences , Beijing , China.; e Center for Neuroscience Research, School of Basic Medical Sciences , Fujian Medical University , Fuzhou , China.
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Źródło:
Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2019 Dec; Vol. 47 (1), pp. 685-695.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Resistance, Neoplasm/*drug effects
Gene Expression Regulation, Neoplastic/*drug effects
MAP Kinase Signaling System/*drug effects
Membrane Glycoproteins/*biosynthesis
Microfilament Proteins/*biosynthesis
Neoplasm Proteins/*metabolism
Paclitaxel/*pharmacology
p38 Mitogen-Activated Protein Kinases/*metabolism
Apoptosis/drug effects ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Down-Regulation ; Female ; Gene Silencing/drug effects ; Humans ; Imidazoles/pharmacology ; Neoplasm Proteins/antagonists & inhibitors ; Pyridines/pharmacology ; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Involvement of p38 mitogen-activated protein kinase in altered expressions of AQP1 and AQP4 after carbon monoxide poisoning in rat astrocytes.
Autorzy:
Li J; Department of Neurology, Enshi Tujia and Miao Autonomous Prefecture Center Hospital, Enshi, China.
Jia M; Department of Neurology, Enshi Tujia and Miao Autonomous Prefecture Center Hospital, Enshi, China.
Chen G; Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China.
Nie S; Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China.
Zheng C; Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zeng W; Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xu Y; Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wang C; Department of Neurology, Enshi Tujia and Miao Autonomous Prefecture Center Hospital, Enshi, China.
Cao X; Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Liu Q; Department of Neurology, Enshi Tujia and Miao Autonomous Prefecture Center Hospital, Enshi, China.
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Źródło:
Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2019 Oct; Vol. 125 (4), pp. 394-404. Date of Electronic Publication: 2019 Jun 03.
Typ publikacji:
Journal Article
MeSH Terms:
Aquaporin 1/*metabolism
Aquaporin 4/*metabolism
Brain Edema/*pathology
Carbon Monoxide Poisoning/*pathology
p38 Mitogen-Activated Protein Kinases/*metabolism
Animals ; Astrocytes/pathology ; Brain/cytology ; Brain/pathology ; Brain Edema/etiology ; Carbon Monoxide Poisoning/etiology ; Disease Models, Animal ; Humans ; Imidazoles/pharmacology ; MAP Kinase Signaling System/drug effects ; Male ; Phosphorylation/drug effects ; Pyridines/pharmacology ; Rats ; Up-Regulation/drug effects ; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
SB203580, a p38MAPK inhibitor, attenuates olfactory dysfunction by inhibiting OSN apoptosis in AR mice (activation and involvement of the p38 mitogen-activated protein kinase in olfactory sensory neuronal apoptosis of OVA-induced allergic rhinitis).
Autorzy:
Gao X; Department of Otolaryngology-Head and Neck Surgery, The Affiliated Qingdao Municipal Hospital of Qingdao University, Qingdao, Shandong, China.; Department of Otolaryngology-Head and Neck Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Li N; Department of Otolaryngology-Head and Neck Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Zhang J; Department of Otolaryngology-Head and Neck Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
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Źródło:
Brain and behavior [Brain Behav] 2019 Jun; Vol. 9 (6), pp. e01295. Date of Electronic Publication: 2019 Apr 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Imidazoles/*pharmacology
Olfactory Receptor Neurons/*drug effects
Protein Kinase Inhibitors/*pharmacology
Pyridines/*pharmacology
Smell/*drug effects
p38 Mitogen-Activated Protein Kinases/*antagonists & inhibitors
Animals ; Apoptosis/drug effects ; Female ; Irritants/toxicity ; MAP Kinase Signaling System/drug effects ; Mice, Inbred BALB C ; Olfaction Disorders/drug therapy ; Olfactory Receptor Neurons/enzymology ; Ovalbumin/toxicity ; Rhinitis, Allergic/chemically induced ; Signal Transduction/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Eclalbasaponin I causes mitophagy to repress oxidative stress-induced apoptosis via activation of p38 and ERK in SH-SY5Y cells.
Autorzy:
Wang W; a School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang , China.; b Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development , Shenyang Pharmaceutical University , Shenyang , China.
Yao GD; a School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang , China.; b Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development , Shenyang Pharmaceutical University , Shenyang , China.
Shang XY; a School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang , China.; b Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development , Shenyang Pharmaceutical University , Shenyang , China.
Zhang YY; a School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang , China.; b Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development , Shenyang Pharmaceutical University , Shenyang , China.
Song XY; a School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang , China.; b Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development , Shenyang Pharmaceutical University , Shenyang , China.
Hayashi T; b Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development , Shenyang Pharmaceutical University , Shenyang , China.; c China-Japan Research Institute of Medical and Pharmaceutical Sciences, Wuya College of Innovation , Shenyang Pharmaceutical University , Shenyang , China.; d Department of Chemistry and Life Science, School of Advanced Engineering , Kogakuin University , Hachioji , Japan.
Zhang Y; a School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang , China.; b Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development , Shenyang Pharmaceutical University , Shenyang , China.
Song SJ; a School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang , China.; b Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development , Shenyang Pharmaceutical University , Shenyang , China.
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Źródło:
Free radical research [Free Radic Res] 2019 Jun; Vol. 53 (6), pp. 655-668. Date of Electronic Publication: 2019 Jun 11.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*drug effects
Extracellular Signal-Regulated MAP Kinases/*metabolism
Mitophagy/*drug effects
Neuroprotective Agents/*pharmacology
Oxidative Stress/*drug effects
Saponins/*pharmacology
p38 Mitogen-Activated Protein Kinases/*metabolism
Aralia/chemistry ; Cell Survival/drug effects ; Enzyme Activation/drug effects ; Humans ; Hydrogen Peroxide/antagonists & inhibitors ; Hydrogen Peroxide/pharmacology ; Imidazoles/pharmacology ; Models, Molecular ; Molecular Conformation ; Neuroprotective Agents/chemistry ; Neuroprotective Agents/isolation & purification ; Protein Kinase Inhibitors/pharmacology ; Pyrazoles/pharmacology ; Pyridazines/pharmacology ; Pyridines/pharmacology ; Saponins/chemistry ; Saponins/isolation & purification ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Shengjiang Powder ameliorates myocardial injury in septic rats by downregulating the phosphorylation of P38-MAPK.
Autorzy:
Qian Y; Department of Emergency Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
Qian F
Zhang W
Zhao L
Shen M
Ding C
Guo J
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Źródło:
Journal of biosciences [J Biosci] 2019 Jun; Vol. 44 (2).
Typ publikacji:
Journal Article
MeSH Terms:
Anti-Inflammatory Agents/*pharmacology
Drugs, Chinese Herbal/*pharmacology
Heart Injuries/*prevention & control
Myocardium/*metabolism
p38 Mitogen-Activated Protein Kinases/*genetics
Animals ; Anti-Inflammatory Agents/chemistry ; Apoptosis/drug effects ; Apoptosis/genetics ; Disease Models, Animal ; Drugs, Chinese Herbal/chemistry ; Gene Expression Regulation ; Heart Injuries/genetics ; Heart Injuries/metabolism ; Heart Injuries/pathology ; Imidazoles/pharmacology ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Male ; Myocardium/pathology ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Phosphorylation/drug effects ; Proliferating Cell Nuclear Antigen/genetics ; Proliferating Cell Nuclear Antigen/metabolism ; Pyridines/pharmacology ; Rats ; Rats, Wistar ; Sepsis ; Signal Transduction ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism ; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Role of P38 mitogen-activated protein kinase on Cx43 phosphorylation in cerebral vasospasm after subarachnoid hemorrhage.
Autorzy:
Lei C; a Department of Neurosurgery , First Affiliated Hospital of Medical College, Shihezi University , Xinjiang , China.
Ruan Y; b Department of Thoracic Surgery and Neurosurgery , Beitun Hospital of the Ten Division of the Xinjiang Production and Construction Corps , Xinjiang , China.
Cai C; a Department of Neurosurgery , First Affiliated Hospital of Medical College, Shihezi University , Xinjiang , China.
He B; a Department of Neurosurgery , First Affiliated Hospital of Medical College, Shihezi University , Xinjiang , China.
Zhao D; a Department of Neurosurgery , First Affiliated Hospital of Medical College, Shihezi University , Xinjiang , China.
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Źródło:
The International journal of neuroscience [Int J Neurosci] 2019 May; Vol. 129 (5), pp. 461-469. Date of Electronic Publication: 2018 Dec 02.
Typ publikacji:
Journal Article
MeSH Terms:
Connexin 43/*metabolism
Enzyme Inhibitors/*pharmacology
Subarachnoid Hemorrhage/*metabolism
Vasospasm, Intracranial/*metabolism
p38 Mitogen-Activated Protein Kinases/*metabolism
Animals ; Connexin 43/drug effects ; Disease Models, Animal ; Imidazoles/pharmacology ; Male ; Phosphorylation/drug effects ; Pyridines/pharmacology ; Rats ; Rats, Sprague-Dawley ; Subarachnoid Hemorrhage/drug therapy ; Vasospasm, Intracranial/drug therapy ; p38 Mitogen-Activated Protein Kinases/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
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