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Tytuł:
Automated GMP production and long-term experience in radiosynthesis of CB 1 tracer [ F]FMPEP-d 2 .
Autorzy:
Lahdenpohja S; Radiopharmaceutical Chemistry Laboratory, Turku PET Centre, University of Turku, Turku, Finland.
Keller T; Radiopharmaceutical Chemistry Laboratory, Turku PET Centre, University of Turku, Turku, Finland.
Forsback S; Radiopharmaceutical Chemistry Laboratory, Turku PET Centre, University of Turku, Turku, Finland.; Department of Chemistry, University of Turku, Turku, Finland.
Viljanen T; Radiopharmaceutical Chemistry Laboratory, Turku PET Centre, University of Turku, Turku, Finland.
Kokkomäki E; Radiopharmaceutical Chemistry Laboratory, Turku PET Centre, University of Turku, Turku, Finland.
Kivelä RV; Hospital Pharmacy, Turku University Hospital, Turku, Finland.
Bergman J; Radiopharmaceutical Chemistry Laboratory, Turku PET Centre, University of Turku, Turku, Finland.
Solin O; Radiopharmaceutical Chemistry Laboratory, Turku PET Centre, University of Turku, Turku, Finland.; Department of Chemistry, University of Turku, Turku, Finland.; Accelerator Laboratory, Turku PET Centre, Åbo Akademi University, Turku, Finland.
Kirjavainen AK; Radiopharmaceutical Chemistry Laboratory, Turku PET Centre, University of Turku, Turku, Finland.
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Źródło:
Journal of labelled compounds & radiopharmaceuticals [J Labelled Comp Radiopharm] 2020 Jul; Vol. 63 (9), pp. 408-418. Date of Electronic Publication: 2020 Jul 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Positron-Emission Tomography*
Pyrrolidinones/*chemical synthesis
Radiochemistry/*methods
Receptor, Cannabinoid, CB1/*metabolism
Automation ; Pyrrolidinones/metabolism
Czasopismo naukowe
Tytuł:
The Rise of Synaptic Density PET Imaging.
Autorzy:
Becker G; GIGA-Cyclotron Research Center-in vivo imaging, University of Liège, Allée du 6 Août, B30, 4000 Liege, Belgium.
Dammicco S; GIGA-Cyclotron Research Center-in vivo imaging, University of Liège, Allée du 6 Août, B30, 4000 Liege, Belgium.
Bahri MA; GIGA-Cyclotron Research Center-in vivo imaging, University of Liège, Allée du 6 Août, B30, 4000 Liege, Belgium.
Salmon E; GIGA-Cyclotron Research Center-in vivo imaging, University of Liège, Allée du 6 Août, B30, 4000 Liege, Belgium.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2020 May 14; Vol. 25 (10). Date of Electronic Publication: 2020 May 14.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Brain/*diagnostic imaging
Neurodegenerative Diseases/*diagnostic imaging
Positron-Emission Tomography/*methods
Pyridines/*pharmacokinetics
Pyrrolidines/*pharmacokinetics
Pyrrolidinones/*pharmacokinetics
Synaptic Vesicles/*pathology
Animals ; Brain/metabolism ; Carbon Radioisotopes ; Clinical Trials as Topic ; Drug Evaluation, Preclinical ; Fluorine Radioisotopes ; Humans ; Macaca mulatta ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/pathology ; Neurons/metabolism ; Neurons/pathology ; Positron-Emission Tomography/standards ; Proof of Concept Study ; Pyridines/chemical synthesis ; Pyrrolidines/chemical synthesis ; Pyrrolidinones/chemical synthesis ; Radiopharmaceuticals/chemical synthesis ; Radiopharmaceuticals/pharmacokinetics ; Rodentia ; Synaptic Vesicles/metabolism
Czasopismo naukowe
Tytuł:
Identification of 3-Methoxyphenylacetic Acid as a Phytotoxin, Produced by Rhizoctonia solani AG-3 TB.
Autorzy:
Li X; Liaoning Key Laboratory of Plant Pathology, College of Plant Protection, Shenyang Agricultural University, Shenyang 110866, China.
Hou H; Liaoning Key Laboratory of Plant Pathology, College of Plant Protection, Shenyang Agricultural University, Shenyang 110866, China.; College of Economics and Management, Liaoning University of Technology, Jinzhou 121001, China.
Liu H; Liaoning Key Laboratory of Plant Pathology, College of Plant Protection, Shenyang Agricultural University, Shenyang 110866, China.
Wang H; Guizhou Institute of Tobacco Science, Guiyang 556099, China.
Cai L; Guizhou Institute of Tobacco Science, Guiyang 556099, China.
An M; Liaoning Key Laboratory of Plant Pathology, College of Plant Protection, Shenyang Agricultural University, Shenyang 110866, China.
Zhang C; Liaoning Key Laboratory of Plant Pathology, College of Plant Protection, Shenyang Agricultural University, Shenyang 110866, China.
Wu Y; Liaoning Key Laboratory of Plant Pathology, College of Plant Protection, Shenyang Agricultural University, Shenyang 110866, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Jan 12; Vol. 28 (2). Date of Electronic Publication: 2023 Jan 12.
Typ publikacji:
Journal Article
MeSH Terms:
Nicotiana*
Toxins, Biological*
Pyrrolidinones ; Rhizoctonia
SCR Organism:
Rhizoctonia solani
Czasopismo naukowe
Tytuł:
Safety, Tolerability, and Pharmacokinetics of Intravenous Doses of PF-07304814, a Phosphate Prodrug Protease Inhibitor for the Treatment of SARS-CoV-2, in Healthy Adult Participants.
Autorzy:
Zhu T; Pfizer Worldwide Research, Development and Medical, Cambridge, Massachusetts, USA.
Pawlak S; Pfizer Clinical Research Unit, New Haven, Connecticut, USA.
Toussi SS; Pfizer Worldwide Research, Development and Medical, Pearl River, New York, USA.
Hackman F; Pfizer Worldwide Research, Development and Medical, Cambridge, UK.
Thompson K; Pfizer Clinical Research Unit, New Haven, Connecticut, USA.
Song W; Pfizer Worldwide Research, Development and Medical, Groton, Connecticut, USA.
Salageanu J; Pfizer Global Product Development, Groton, Connecticut, USA.
Winter E; Pfizer Global Product Development, Groton, Connecticut, USA.
Shi H; Pfizer Global Product Development, Groton, Connecticut, USA.
Winton J; Pfizer Global Product Development, Groton, Connecticut, USA.
Binks M; Pfizer Worldwide Research, Development and Medical, Cambridge, Massachusetts, USA.
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Źródło:
Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2022 Dec; Vol. 11 (12), pp. 1382-1393. Date of Electronic Publication: 2022 Oct 26.
Typ publikacji:
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
COVID-19 Drug Treatment*
Prodrugs*/adverse effects
Adult ; Humans ; Antiviral Agents/adverse effects ; Healthy Volunteers ; Indoles ; Organophosphates ; Phosphates ; Protease Inhibitors/adverse effects ; Pyrrolidinones ; SARS-CoV-2
Czasopismo naukowe
Tytuł:
Streptococcus mutans suppresses filamentous growth of Candida albicans through secreting mutanocyclin, an unacylated tetramic acid.
Autorzy:
Tao L; Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
Wang M; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Guan G; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Zhang Y; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Hao T; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Li C; Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Li S; Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
Chen Y; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Huang G; Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.; Shanghai Engineering Research Center of Industrial Microorganisms.
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Źródło:
Virulence [Virulence] 2022 Dec; Vol. 13 (1), pp. 542-557.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Candida albicans*/metabolism
Streptococcus mutans*/genetics
Biofilms ; Humans ; Pyrrolidinones/metabolism
Czasopismo naukowe
Tytuł:
Proline, hydroxyproline, and pyrrolidone carboxylic acid derivatives as highly efficient but reversible transdermal permeation enhancers.
Autorzy:
Kopečná M; Skin Barrier Research Group, Charles University, Faculty of Pharmacy in Hradec Králové, Akademika Heyrovského 1203, 50005, Hradec Králové, Czech Republic.
Macháček M; Department of Biochemical Sciences, Charles University, Faculty of Pharmacy in Hradec Králové, Akademika Heyrovského 1203, 50005, Hradec Králové, Czech Republic.
Roh J; Department of Organic and Bioorganic Chemistry, Charles University, Faculty of Pharmacy in Hradec Králové, Akademika Heyrovského 1203, 50005, Hradec Králové, Czech Republic.
Vávrová K; Skin Barrier Research Group, Charles University, Faculty of Pharmacy in Hradec Králové, Akademika Heyrovského 1203, 50005, Hradec Králové, Czech Republic. .
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Źródło:
Scientific reports [Sci Rep] 2022 Nov 14; Vol. 12 (1), pp. 19495. Date of Electronic Publication: 2022 Nov 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Skin Absorption*
Proline*/metabolism
Humans ; Hydroxyproline/metabolism ; Permeability ; Administration, Cutaneous ; Skin/metabolism ; Pharmaceutical Preparations/metabolism ; Organic Chemicals/metabolism ; Pyrrolidinones/pharmacology ; Carboxylic Acids/metabolism
Czasopismo naukowe
Tytuł:
Cobalt‐Catalyzed Selective Transformation of Levulinic Acid and Amines into Pyrrolidines and Pyrrolidinones using Hydrogen.
Autorzy:
Pan, Yixiao (AUTHOR)
Luo, Zhenli (AUTHOR)
Yang, Ji (AUTHOR)
Han, Jiahong (AUTHOR)
Yang, Jianbo (AUTHOR)
Yao, Zhen (AUTHOR)
Xu, Lijin (AUTHOR)
Wang, Peng (AUTHOR)
Shi, Qian (AUTHOR)
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Źródło:
Advanced Synthesis & Catalysis. 8/16/2022, Vol. 364 Issue 16, p2830-2836. 7p.
Czasopismo naukowe
Tytuł:
Cellulose Nanofiber Modified Poly (Acrylic Acid-Co-N-Vinyl Pyrrolidone) Hydrogel as Forward Osmosis Draw Agent.
Autorzy:
Vafaei, Mohammad Ali (AUTHOR)
Shakeri, Alireza (AUTHOR)
Salehi, Hasan (AUTHOR)
Razavi, Seyed Reza (AUTHOR)
Salari, Narges (AUTHOR)
Nakhjiri, Mahdi Taghvay (AUTHOR)
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Temat:
*Reverse osmosis process (Sewage purification)
Osmosis
Hydrogels
Fourier transform infrared spectroscopy
Osmotic pressure
Surface chemistry
Pyrrolidinones
Źródło:
Journal of Polymers & the Environment. Oct2023, Vol. 31 Issue 10, p4369-4381. 13p.
Czasopismo naukowe
Tytuł:
Microtubule disrupting agent-mediated inhibition of cancer cell growth is associated with blockade of autophagic flux and simultaneous induction of apoptosis.
Autorzy:
Hasanain M; Biochemistry Division, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India.; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh, India.
Sahai R; Electron Microscopy Unit, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India.
Pandey P; Biochemistry Division, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India.
Maheshwari M; Biochemistry Division, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India.
Choyal K; Biochemistry Division, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India.
Gandhi D; Biochemistry Division, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India.
Singh A; Biochemistry Division, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India.
Singh K; Electron Microscopy Unit, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India.
Mitra K; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh, India.; Electron Microscopy Unit, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India.
Datta D; Biochemistry Division, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India.; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh, India.
Sarkar J; Biochemistry Division, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India.; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh, India.
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Źródło:
Cell proliferation [Cell Prolif] 2020 Apr; Vol. 53 (4), pp. e12749. Date of Electronic Publication: 2020 Mar 13.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*therapeutic use
Cell Proliferation/*drug effects
Neoplasms/*drug therapy
Pyrrolidinones/*therapeutic use
Tubulin Modulators/*therapeutic use
Animals ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Autophagy/drug effects ; Cell Line, Tumor ; Female ; Humans ; Mice ; Mice, Nude ; Microtubules/drug effects ; Microtubules/metabolism ; Microtubules/pathology ; Neoplasms/metabolism ; Neoplasms/pathology ; Pyrrolidinones/pharmacology ; Tubulin Modulators/pharmacology
Czasopismo naukowe
Tytuł:
Automated radiosynthesis of [ C]UCB-J for imaging synaptic density by positron emission tomography.
Autorzy:
Milicevic Sephton S; Radiopharmaceutical Unit, Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Miklovicz T; Radiopharmaceutical Unit, Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; University of Debrecen, Faculty of Medicine Department of Medical Imaging, Division of Nuclear Medicine and Translational Imaging, Department of Medical Imaging, Faculty of Medicine H-4032 Nagyerdei krt. 98, University of Debrecen, Debrecen, Hungary.
Russell JJ; Radiopharmaceutical Unit, Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Doke A; Radiopharmaceutical Unit, Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Li L; Radiopharmaceutical Unit, Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Boros I; Radiopharmaceutical Unit, Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Aigbirhio FI; Radiopharmaceutical Unit, Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
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Źródło:
Journal of labelled compounds & radiopharmaceuticals [J Labelled Comp Radiopharm] 2020 Mar; Vol. 63 (3), pp. 151-158. Date of Electronic Publication: 2020 Feb 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Positron-Emission Tomography*
Pyridines/*chemical synthesis
Pyrrolidinones/*chemical synthesis
Synapses/*metabolism
Animals ; Automation ; Brain/diagnostic imaging ; Brain/metabolism ; Chemistry Techniques, Synthetic ; Macaca mulatta ; Palladium/chemistry ; Pyridines/chemistry ; Pyrrolidinones/chemistry ; Radiochemistry
Czasopismo naukowe
Tytuł:
A selective androgen receptor modulator SARM-2f activates androgen receptor, increases lean body mass, and suppresses blood lipid levels in cynomolgus monkeys.
Autorzy:
Morimoto M; Oncology Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa, Japan.
Yamaoka M; Oncology Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa, Japan.
Hara T; Oncology Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa, Japan.
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Źródło:
Pharmacology research & perspectives [Pharmacol Res Perspect] 2020 Feb; Vol. 8 (1), pp. e00563.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Lipid Metabolism/*drug effects
Pyrrolidinones/*administration & dosage
Receptors, Androgen/*metabolism
Administration, Oral ; Animals ; Body Mass Index ; Body Weight/drug effects ; COS Cells ; Chlorocebus aethiops ; Female ; Humans ; Macaca fascicularis ; Male ; Pyrrolidinones/pharmacokinetics ; Rats
Czasopismo naukowe
Tytuł:
A new human cadaver model for laparoscopic training using N-vinyl-2-pyrrolidone: a feasibility study.
Autorzy:
Nagase M; Department of Anatomy, Kyorin University Faculty of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan. .
Kimoto Y; Department of Anatomy, Kyorin University Faculty of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan.
Sunami E; Department of Surgery, Kyorin University Faculty of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan.
Matsumura G; Department of Anatomy, Kyorin University Faculty of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan.
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Źródło:
Anatomical science international [Anat Sci Int] 2020 Jan; Vol. 95 (1), pp. 156-164. Date of Electronic Publication: 2019 Jul 26.
Typ publikacji:
Journal Article
MeSH Terms:
Cadaver*
Models, Anatomic*
Pyrrolidinones*
Anatomy/*education
Education, Medical/*methods
Laparoscopy/*education
Feasibility Studies ; Humans
Czasopismo naukowe
Tytuł:
Synthesis and in vivo evaluation of [ F]UCB-J for PET imaging of synaptic vesicle glycoprotein 2A (SV2A).
Autorzy:
Li S; PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, 06520, USA. .
Cai Z; PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, 06520, USA. .
Zhang W; Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, China.
Holden D; PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, 06520, USA.
Lin SF; PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, 06520, USA.
Finnema SJ; PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, 06520, USA.
Shirali A; PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, 06520, USA.
Ropchan J; PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, 06520, USA.
Carre S; UCB Biopharma, Braine-l'Alleud, Belgium.
Mercier J; UCB Biopharma, Braine-l'Alleud, Belgium.
Carson RE; PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, 06520, USA.
Nabulsi N; PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, 06520, USA.
Huang Y; PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, 06520, USA.
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Źródło:
European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2019 Aug; Vol. 46 (9), pp. 1952-1965. Date of Electronic Publication: 2019 Jun 07.
Typ publikacji:
Journal Article
MeSH Terms:
Positron-Emission Tomography*
Fluorine Radioisotopes/*chemistry
Membrane Glycoproteins/*metabolism
Pyridines/*chemical synthesis
Pyrrolidinones/*chemical synthesis
Animals ; Chemistry Techniques, Synthetic ; Female ; Macaca mulatta ; Male ; Pyridines/chemistry ; Pyrrolidinones/chemistry ; Radiochemistry
Czasopismo naukowe
Tytuł:
The Role of Orientation of Surface Bound Dihydropyrrol-2-ones (DHP) on Biological Activity.
Autorzy:
Taunk A; School of Chemistry, University of New South Wales, Sydney 2052, Australia.
Chen R; School of Chemistry, University of New South Wales, Sydney 2052, Australia.
Iskander G; School of Chemistry, University of New South Wales, Sydney 2052, Australia.
Ho KKK; School of Chemistry, University of New South Wales, Sydney 2052, Australia.
Almohaywi B; School of Chemistry, University of New South Wales, Sydney 2052, Australia.
Black DS; School of Chemistry, University of New South Wales, Sydney 2052, Australia.
Willcox MDP; School of Optometry and Vision Science, University of New South Wales, Sydney 2052, Australia.
Kumar N; School of Chemistry, University of New South Wales, Sydney 2052, Australia. .
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2019 Jul 23; Vol. 24 (14). Date of Electronic Publication: 2019 Jul 23.
Typ publikacji:
Journal Article
MeSH Terms:
Anti-Bacterial Agents/*pharmacology
Biofilms/*drug effects
Pseudomonas aeruginosa/*drug effects
Pyrrolidinones/*pharmacology
Quorum Sensing/*drug effects
Staphylococcus aureus/*drug effects
Anti-Bacterial Agents/chemical synthesis ; Bacterial Adhesion/drug effects ; Biofilms/growth & development ; Carbodiimides/chemistry ; Cross-Linking Reagents/chemistry ; Microbial Sensitivity Tests ; Pseudomonas aeruginosa/growth & development ; Pyrrolidinones/chemical synthesis ; Staphylococcus aureus/growth & development ; Structure-Activity Relationship ; Succinimides/chemistry
Czasopismo naukowe
Tytuł:
The 3 S Enantiomer Drives Enolase Inhibitory Activity in SF2312 and Its Analogues.
Autorzy:
Pisaneschi F; Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA. .
Lin YH; Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Leonard PG; Institute of Applied Cancer Science, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.; Core for Biomolecular Structure and Function, Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Satani N; Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Yan VC; Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Hammoudi N; Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Raghavan S; Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Link TM; Core for Biomolecular Structure and Function, Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
K Georgiou D; Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Czako B; Institute of Applied Cancer Science, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Muller FL; Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA. .
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2019 Jul 09; Vol. 24 (13). Date of Electronic Publication: 2019 Jul 09.
Typ publikacji:
Journal Article
MeSH Terms:
Enzyme Inhibitors/*pharmacology
Organophosphonates/*pharmacology
Phosphopyruvate Hydratase/*antagonists & inhibitors
Phosphopyruvate Hydratase/*chemistry
Pyrrolidinones/*pharmacology
Binding Sites ; Enzyme Activation/drug effects ; Enzyme Inhibitors/chemistry ; Models, Molecular ; Molecular Conformation ; Molecular Structure ; Organophosphonates/chemistry ; Protein Binding ; Pyrrolidinones/chemistry ; Spectrum Analysis ; Stereoisomerism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł:
Evaluating the In Vivo Specificity of [ F]UCB-H for the SV2A Protein, Compared with SV2B and SV2C in Rats Using microPET.
Autorzy:
Serrano ME; GIGA-CRC In Vivo Imaging, University of Liège, 8 Allée du 6 Août, Building B30, Sart Tilman, 4000 Liège, Belgium. .
Becker G; GIGA-CRC In Vivo Imaging, University of Liège, 8 Allée du 6 Août, Building B30, Sart Tilman, 4000 Liège, Belgium. .
Bahri MA; GIGA-CRC In Vivo Imaging, University of Liège, 8 Allée du 6 Août, Building B30, Sart Tilman, 4000 Liège, Belgium. .
Seret A; GIGA-CRC In Vivo Imaging, University of Liège, 8 Allée du 6 Août, Building B30, Sart Tilman, 4000 Liège, Belgium. .
Mestdagh N; UCB Pharma s.a., 1420 Braine-l'Alleud, Belgium. .
Mercier J; UCB Pharma s.a., 1420 Braine-l'Alleud, Belgium. .
Mievis F; Nucleis s.a., University of Liège, 8 Allée du 6 Août, Building B30, Sart Tilman, 4000 Liège, Belgium. .
Giacomelli F; Nucleis s.a., University of Liège, 8 Allée du 6 Août, Building B30, Sart Tilman, 4000 Liège, Belgium. .
Lemaire C; GIGA-CRC In Vivo Imaging, University of Liège, 8 Allée du 6 Août, Building B30, Sart Tilman, 4000 Liège, Belgium. .
Salmon E; GIGA-CRC In Vivo Imaging, University of Liège, 8 Allée du 6 Août, Building B30, Sart Tilman, 4000 Liège, Belgium. .
Luxen A; GIGA-CRC In Vivo Imaging, University of Liège, 8 Allée du 6 Août, Building B30, Sart Tilman, 4000 Liège, Belgium. .
Plenevaux A; GIGA-CRC In Vivo Imaging, University of Liège, 8 Allée du 6 Août, Building B30, Sart Tilman, 4000 Liège, Belgium. .
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2019 May 01; Vol. 24 (9). Date of Electronic Publication: 2019 May 01.
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
Brain/*diagnostic imaging
Membrane Glycoproteins/*metabolism
Nerve Tissue Proteins/*metabolism
Pyridines/*metabolism
Pyrrolidinones/*metabolism
Animals ; Brain/metabolism ; Levetiracetam/administration & dosage ; Levetiracetam/pharmacology ; Magnetic Resonance Imaging ; Male ; Models, Animal ; Molecular Structure ; Positron-Emission Tomography ; Pyridines/chemistry ; Pyrrolidinones/chemistry ; Rats ; Rats, Sprague-Dawley ; Sensitivity and Specificity
Czasopismo naukowe
Tytuł:
The Antiarrhythmic and Hypotensive Effects of S-61 and S-73, the Pyrrolidin-2-one Derivatives with α 1 -Adrenolytic Properties.
Autorzy:
Lustyk K; Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland.
Sałaciak K; Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland.
Siwek A; Department of Pharmacobiology, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland.
Sapa J; Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland.
Zaręba P; Department of Physiochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland.
Gałuszka A; Department of Automatic Control and Robotics, Silesian University of Technology, Akademicka 2A, 44-100 Gliwice, Poland.
Pytka K; Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Sep 08; Vol. 23 (18). Date of Electronic Publication: 2022 Sep 08.
Typ publikacji:
Journal Article
MeSH Terms:
Anti-Arrhythmia Agents*/pharmacology
Anti-Arrhythmia Agents*/therapeutic use
Antihypertensive Agents*/pharmacology
Aconitine/adverse effects ; Adrenergic Antagonists ; Animals ; Arrhythmias, Cardiac/chemically induced ; Arrhythmias, Cardiac/drug therapy ; Arrhythmias, Cardiac/prevention & control ; Calcium Chloride ; Epinephrine/pharmacology ; Epinephrine/therapeutic use ; Methoxamine ; Pyrrolidinones/pharmacology ; Rats ; Rats, Wistar ; Receptors, Adrenergic, alpha-1 ; Receptors, Adrenergic, beta-1
Czasopismo naukowe
Tytuł:
Excised human larynx in N-vinyl-2-pyrrolidone-embalmed cadavers can produce voiced sound by pliable vocal fold vibration.
Autorzy:
Miyamoto M; Department of Otolaryngology-Head and Neck Surgery, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 1818611, Japan.
Nagase M; Department of Anatomy, Kyorin University School of Medicine, Tokyo, Japan.
Watanabe I; Department of Otolaryngology-Head and Neck Surgery, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 1818611, Japan.
Nakagawa H; Department of Otolaryngology-Head and Neck Surgery, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 1818611, Japan.
Karita K; Department of Hygiene and Public Health, Kyorin University School of Medicine, Tokyo, Japan.
Tsuji DH; Department of Otolaryngology, University of São Paulo School of Medicine, São Paulo, Brazil.
Montagnoli AN; Department of Electric Engineering, Federal University of São Carlos, São Paulo, Brazil.
Matsumura G; Department of Anatomy, Kyorin University School of Medicine, Tokyo, Japan.
Saito K; Department of Otolaryngology-Head and Neck Surgery, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 1818611, Japan. .
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Źródło:
Anatomical science international [Anat Sci Int] 2022 Sep; Vol. 97 (4), pp. 347-357. Date of Electronic Publication: 2022 Feb 03.
Typ publikacji:
Journal Article
MeSH Terms:
Larynx*
Vocal Cords*/physiology
Cadaver ; Embalming ; Humans ; Pyrrolidinones ; Reproducibility of Results ; Vibration
Czasopismo naukowe

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