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Tytuł :
Recombinant IL-21 induces perforin and granzyme B in total and virus specific CD8 Tcells in acute and early stages of SIV infection in rhesus macaques
Autorzy :
Pallikkuth S
Micci L
Ende Z
Rogers K
Silvestry G
Villinger F
Paiardini M
Pahwa S
Pokaż więcej
Temat :
Immunologic diseases. Allergy
RC581-607
Źródło :
Retrovirology, Vol 9, Iss Suppl 2, p P13 (2012)
Opis pliku :
electronic resource
Relacje :
https://doaj.org/toc/1742-4690
Dostęp URL :
https://doaj.org/article/3726e68f41a749d7a2cdfc38766a8b05
Czasopismo naukowe
Tytuł :
Track A Basic Science
THPDA0203: HIVToolbox: an integrated web application for investigating HIV
WEAA0103: Production and characterization of human anti-V3 monoclonal antibodies from Indian clade C human immunodeficiency virus type-1 (HIV-1) infected patients
TUPDA0104: Characterization of broadly neutralizing antibodies (bNAbs) to HIV-1 present in a cohort of long term non-progressors (LTNPs)
MOAA0202: The majority of freshly sorted SIV-specific CD8+ T cells cannot suppress viral replication in SIV-infected macrophages
MOLBA04: Comparative activity of IgA mediated antibody dependent cell-mediated cytotoxicity (ADCC) in the genital mucosa of HIV seroconverters and highly exposed seronegative women
TUPDA0101: The colocalization potential of HIV-specific CD8+ and CD4+ T cells is mediated by integrin β7 but not CCR6 and regulated by retinoic acid
TUPDA0105: Enhanced TCR affinity imparts specificity to reverse transcriptase inhibitor resistance-associated mutations
MOAA0201: HIV controllers maintain a population of highly efficient Th1 effector cells in spite of persistently low viral antigenemia
MOAA0204: Natural control of HIV infection is associated with an isotype switched IgG antibody response to HIV core antigens in patients with ‘non-protective’ HLA-B alleles
MOPDA0104: ZNDR1 gene affects host susceptibility to HIV-1 infection
TUPDB0201: Evidence for T cell immune quiescence in the genital mucosa of HIV exposed seronegative commercial sex workers
WEPDA0105: Highly HIV exposed seronegative (HESN) sex workers from Nairobi, Kenya have altered innate mucosal immune responses at the level of the female genital tract
THPDA0103: Low magnitude and frequency of HSV-2-specific interferon gamma-producing CD4+ and CD8+ T cell responses detected in HIV-1 heterosexual discordant couples
TUAA0304: Oral serum-derived bovine immunoglobulin (SBI) administration leads to duodenal gastrointestinal-associated lymphoid tissue (GALT) CD4+ T-lymphocyte increases and improved small intestinal absorption function in an 8-week pilot study in patients with HIV-enteropathy
TUAA0305: Improved intestinal immunity and cytotoxic potential of T cells in interleukin (IL)-21 treated SIV-infected rhesus macaques
WEPDA0103: Induction and maintenance of HIV-1-specific immune responses in exposed seronegative (ESN) women of serodiscordant couples from southern India
TUAA0104: Glut1: establishing a new paradigm for HIV-1 infection by regulating glucose metabolism and activation in CD4+ T cells in HIV-1-positive subjects
WEAA0204: HIV-induced CD4 T cell depletion: an innate host defense gone awry
TUPDA0102: Elite controllers show a unique Tryptophan immunosuppressive catabolism
MOAA0205: IL-7 suppresses transcription of the IL-7 receptor alpha (CD127) gene in human CD8 T cells by inducing the expression of a STAT5-dependent transcriptional repressor
WEAA0205: Suppressor of cytokine signalling (SOCS) proteins are induced by IL-7 and the interaction of SOCS proteins with the IL-7 receptor alpha (CD127) may play a role in regulating CD127 expression in human CD8 T cells
WEAA0202: Differential SIV infection patterns of lymph node-resident CD4 T cells distinguishes progressive from nonprogressive SIV infection
TUAA0102: Third generation long-read sequencing of HIV-1 transcripts discloses cell type specific and temporal regulation of RNA splicing
WEPDA0205: HIV-1 Tat protein up-regulates human cellular miRNAs involved in T cell apoptosis: requirement of Tat second exon
TUAA0101: Discovery of novel transcription factors present only in infected cells
MOAA0102: Myeloid dendritic cells and HIV latency in resting T cells
TUAA0201: Unique regulatory mechanisms of CNS-derived HIV-1 LTRs associated with latency
TUAA0202: Complete transcriptome analysis of latently infected CD4+ T cells
TUAA0204: Epigenetic modifications of HIV proviral LTRs: potential targets for cure
TUAA0205: Unique integration patterns: in vitro model of HIV latency
THAA0104: SIVagm infection of rhesus macaques: a model of functional cure with persistent reservoirs of replication-competent virus
MOLBA01: Unintegrated HIV-1 generates an inducible reservoir of replication competent virus in nonproliferating CD4+ T cells
WEPDA0202: Role of UHRF1 in transcriptional regulation and maintenance of HIV-1 latency
WEPDA0203: Modeling HIV latency using the humanized BLT mouse
WEPDA0204: Maraviroc (MVC) can activate NFkB in resting CD4 T cells of patients infected with R5 or D/M HIV-1
THPDA0205: CXCR4-tropism is associated with the preferential establishment of an HIV-reservoir in naïve CD4+ T cells among HIV-positive Ugandan children receiving antiretroviral therapy
THAA0101: Long-term reduction in peripheral blood HIV-1 reservoirs following reduced-intensity conditioning allogeneic stem cell transplantation in two HIV-positive individuals
MOLBA02: Evaluation of treatment with the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid; SAHA) in antiretroviral drug treated, SIVmac239-infected rhesus macaques
THPDA0201: The cure of the 'Berlin patient': why did pre-existing X4-variants not emergence after allogeneic CCR5-Δ32 SCT
THAA0102: Viral tissue reservoirs are determined early and little viral RNA is detected during suppression by three or four drug regimens in the macaque model
THAA0105: Characterization of persistent HIV-1 in a broad spectrum of CD4+ T cells isolated from peripheral blood and gut associated lymphoid tissue from patients on long-term suppressive therapy
TUAA0103: Anti-APOBEC3G activity of HIV-1 Vif protein from elite controllers is attenuated compared to those from untreated chronic progressors or those from individuals with acute infection
TUAA0203: CBF-1 induces both establishment and maintenance of HIV latency via recruiting PcG corepressor complex at LTR
THAA0103: Distribution of the HIV reservoir in patients spontaneously controlling HIV infection after treatment interruption
MOPDA0105: Immune and inflammatory gene expression in the periphery and CNS of cART-treated SIV-infected macaques
MOPDA0101: Toll-like receptor (TLR) 9 variant is associated with mother-to-child transmission (MTCT) of HIV-1 and TLR9 and TLR8 variants are associated with peak viral load in HIV-1-positive infants
MOPDA0102: Polymorphisms in TLR2 and TLR7 are associated with plasma HIV-1 RNA set-point in an African heterosexual cohort
MOPDA0103: Association of polymorphisms in the regulatory region of cyclophilin A gene (PPIA) with disease progression and gene expression levels
WEPDA0101: HLA class I associations with rates of HIV-1 seroconversion and disease progression in the Pumwani sex worker cohort
WEPDA0206: TRIM22 repression of HIV-1 transcription is mediated by interaction with SP1
THPDA0204: Apobec3G levels are inversely associated with resting CD4+ T memory cell integrated provirus in vivo and infectivity of reactivated HIV-1 ex vivo
WEPDA0201: Integration of global techniques to implicate post-transcriptional regulation in HIV infection
MOAA0101: The effect of liquefaction on the ability of semen and semen amyloid fibrils to enhance HIV infection
MOAA0103: Impact of depot medroxyprogesterone (DMPA) on human vaginal leukocytes and HIV-1 target cells
MOAA0105: HIV-1 transmission from semen to cervicovaginal tissue ex vivo
MOLBA03: HIV-1 female-to-male sexual transmission: evaluation of circumcised and uncircumcised penile tissue
WEAA0105: The HIV-1 envelope protein gp120 mimics MAdCAM and VCAM in binding to Integrin-α4β7
MOAA0203: HIV-1 peptide-specific NK cell responses in HIV seropositive and highly exposed seronegative men
WEPDA0102: Highly-exposed HIV seronegative persons (HESN) had higher levels of inflammatory and immune activation-associated serum biomarkers than lower risk HIV seroconverters (LRSC)
Autorzy :
Sargeant, D.
Deverasetty, S.
Luo, Y.
Villahoz-Baleta, A.
Zobrist, S.
Rathnayake, V.
Russo, J.
Muesing, M.
Schiller, M.
Andrabi, R.
Kumar, R.
Bala, M.
Nair, A.
Biswas, A.
Wig, N.
Kumar, P.
Luthra, K.
Gonzalez, N.
McKee, K.
Yuste, E.
Mascola, J.R.
Alcamí, J.
Vojnov, L.
Martins, M.
Bean, A.
Veloso de Santana, M.
Sacha, J.
Wilson, N.
Bonaldo, M.
Galler, R.
Stevenson, M.
Watkins, D.
Aziz, M.
Mata, M.
Mahmood, F.
Durkin, H.
Liu, C.
Greenblatt, R.
Nowicki, M.
Golub, E.
Anastos, K.
French, A.
Baum, L.
Wacleche, V.S.
Chomont, N.
Gosselin, A.
Monteiro, P.
Goupil, M.
Kared, H.
Tremblay, C.
Bernard, N.
Boulassel, M.-R.
Routy, J.-P.
Ancuta, P.
Jadlowsky, J.
Baiduc, C.
Richardson, M.
Bennett, A.
Jakobsen, B.
Riley, J.L.
Vingert, B.
Benati, D.
Lambotte, O.
de Truchis, P.
Slama, L.
Jeannin, P.
Perez-Patrigeon, S.
Boufassa, F.
Kwok, W.W.
Lemaître, F.
Delfraissy, J.-F.
Thèze, J.
Chakrabarti, L.A.
French, M.
Center, R.
Wilson, K.
Fleyfel, I.
Fernandez, S.
Kelleher, A.
An, P.
Goedert, J.
Donfield, S.
Buchbinder, S.
Kirk, G.
Detels, R.
Winkler, C.
Lajoie, J.
Juno, J.
Burgener, A.
Rahman, S.
Mogk, K.
Wachihi, C.
Mwanjewe, J.
Plummer, F.A.
Kimani, J.
Ball, T.B.
Fowke, K.R.
Fowke, K.
Dieye, T.N.
Chentouffi, A.
Camara, M.
Sarr, S.
Tran, M.V.
Seydi, M.
Dasgupta, G.
Fall, M.
Daneau, G.
Diaw, P.A.
Kestens, L.
Sow, P.S.
Mboup, S.
Benmohamed, L.
Asmuth, D.M.
Ma, Z.-M.
Albanese, A.
Devaraj, S.
Hodzic, E.
Garcia, J.-C.
Knight, T.H.
Flynn, N.M.
Mann, S.
Yotter, T.
Tsuchida, E.
Miller, C.J.
Pallikkuth, S.
Micci, L.
Ende, Z.
Iriele, R.
Cervasi, B.
Else, J.
Silvestri, G.
Villinger, F.
Pahwa, S.
Paiardini, M.
Solomon, S.
Murugavel, K.G.
Vignesh, R.
Bella, D.
Shoba, R.
Poongulali, S.
Kumarasamy, N.
Landay, A.
Solomon, S.S.
Swathirajan, C.R.
Balakrishnan, P.
Cu-Uvin, S.
Mayer, K.H.
Shacklett, B.L.
Palmer, C.S.
Zhou, J.
Saleh, S.
Lam, L.
Hearps, A.
Maisa, A.
Pereira, C.
Lewin, S.
Jaworowski, A.
McCune, J.M.
Crowe, S.
Doitsh, G.
Galloway, N.
Monroe, K.
Yang, Z.
Zepeda, O.
Greene, W.C.
Patel, M.
Jenabian, M.-A.
Lebouché, B.
Brouillette, M.-J.
Kema, I.
Al-Ghazawi, F.
Faller, E.
Parmar, P.
Kakal, J.
MacPherson, P.
Sugden, S.
Sant, N.
Vinton, C.
Brenchley, J.
Tabb, B.
Hao, X.P.
Hirsch, V.M.
Lifson, J.
Estes, J.D.
Bushman, F.
Sherrill-Mix, S.
Ocwieja, K.
Mukherjee, R.
Brown, M.
Chin, J.
Custers-Allen, R.
David, P.
Olson, J.
Travers, K.
Schadt, E.
Sánchez del Cojo, M.
López-Huertas, M.R.
Mateos, E.
Coiras, M.
Sampey, G.
Van Duyne, R.
Guendel, I.
Gregg, E.
Shafagati, N.
Tyagi, M.
Easely, R.
Klase, Z.
Romerio, F.
Iglesias-Ussel, M.
Nekhai, S.
Kehn-Hall, K.
Kashanchi, F.
Kumar, N.
Evans, V.
Pereira, C.F.
Ellenberg, P.
Cameron, P.U.
Lewin, S.R.
Gray, L.
Cowley, D.
Crespan, E.
Welsh, C.
Mackenzie, C.
Gorry, P.
Wesselingh, S.
Churchill, M.
Marchionni, L.
Weber, S.
Burger, H.
Kemal, K.
Weiser, B.
Korn, K.
Doerfler, W.
Vatakis, D.
Cameron, P.
Harman, A.
Cunningham, A.
Ma, D.
Cillo, A.
Xu, C.L.
Kristoff, J.
Fang, J.
Haret-Richter, G.
Mellors, J.
Pandrea, I.
Apetrei, C.
Trinité, B.
Ohlson, E.
Rana, S.
Alster, J.
Levy, D.N.
Victoriano, A.F.B.
Hibi, Y.
Tan Gana, N.
Asamitsu, K.
Okamoto, T.
Marsden, M.
Kovochich, M.
Suree, N.
Shimizu, S.
Mehta, R.
Cortado, R.
Bristol, G.
An, D.S.
Zack, J.
Madrid-Elena, N.
Hernandez-Novoa, B.
Lamas, M.
Garcia-Bermejo, L.
Moreno, S.
Ruel, T.
Achan, J.
Huang, W.
Cao, H.
Li, P.
Eller, L.A.
Killian, M.
Sinclair, E.
Charlebois, E.
Havlir, D.V.
Wong, J.
Henrich, T.J.
Sciaranghella, G.
Li, J.Z.
Gallien, S.
Ho, V.
Lacasce, A.S.
Kuritzkes, D.R.
Del Prete, G.
Kiser, R.
Trubey, C.M.
Smedley, J.
Coalter, V.
Oswald, K.
Shoemaker, R.
Fast, R.
Li, Y.
Lara, A.
Wiles, A.
Wiles, R.
Macallister, R.
Sanchez, R.
Wai, J.
Tan, C.
Keele, B.
Estes, J.
Piatakjr, M.
Hazuda, D.
Symons, J.
Deeks, S.
Hutter, G.
Wensing, A.
Martin, J.
van Ham, P.
Vandekerckhove, L.
Nijhuis, M.
Kline, C.
Ndjomou, J.
Franks, T.
Piatak, M.
Ambrose, Z.
Josefsson, L.
Eriksson, S.
Ho, T.
Epling, L.
Tan, A.
Lemey, P.
Faria, N.R.
Shao, W.
Hunt, P.
Somsouk, M.
Douek, D.
Bacchetti, P.
Loeb, L.
Custer, J.
Poole, L.
Hecht, F.M.
Palmer, S.
Kikuchi, T.
Iwabu, Y.
Kawana-Tachikawa, A.
Koga, M.
Hosoya, N.
Nomura, S.
Brumme, Z.L.
Jessen, H.
Markowitz, M.
Pereyra, F.
Trocha, A.
Walker, B.D.
Iwamoto, A.
Tokunaga, K.
Miura, T.
Bacchus, C.
Hocqueloux, L.
Avettand-Fenoël, V.
Saez-Cirion, A.
Mélard, A.
Descours, B.
Samri, A.
Blanc, C.
Autran, B.
Rouzioux, C.
Zink, M.C.
Graham, D.R.
Gama, L.
Queen, S.E.
Meulendyke, K.A.
Mankowski, J.L.
Clements, J.E.
Beima-Sofie, K.
Bigham, A.
Lingappa, J.R.
Wamalwa, D.
Mackelprang, R.D.
Maleche-Obimbo, E.
Richardson, B.
John-Stewart, G.
Mackelprang, R.
Celum, C.
de Bruyn, G.
Beima, K.
Ronald, A.
Mugo, N.
Rainer, A.
Buckingham, K.
Bamshad, M.
Mullins, J.
McElrath, J.
Lingappa, J.
Madlala, P.
Singh, R.
Werner, L.
Sibeko, S.
Karim, S.S.A.
Winkler, C.A.
Ndung'u, T.
Peterson, T.
Bielawny, T.
Mendoza, L.
Thavaneswaran, S.
Narayansingh, M.
Kariri, T.
Liang, B.
Ngugi, E.
Plummer, F.
Luo, M.
Kajaste-Rudnitski, A.
Marelli, S.
Poli, G.
Berkhout, B.
Das, A.T.
Vicenzi, E.
De Pasquale, M.
Kourteva, Y.
Allos, T.
D'Aquila, R.
Blackinton, J.
Thompson, M.
Mukherjee, N.
Freel, S.
Tomaras, G.
Keene, J.
Roan, N.
Muller, J.
Gawanbacht, A.
Zirafi, O.
Chu, S.
Kirchhoff, F.
Munch, J.
Greene, W.
Chandra, N.
Thurman, A.
Anderson, S.
Cunningham, T.
Mauck, C.
Doncel, G.
Introini, A.
Vanpouille, C.
Lisco, A.
Grivel, J.-C.
Munawwar, A.
Singh, S.
Margolis, L.
Dinh, M.
Anderson, M.
Gioia, C.
McRaven, M.
Okocha, Z.
Cianci, G.
Hirbod, T.
Kigozi, G.
Prodger, J.
Kaul, R.
Kong, X.
Gray, R.
Hope, T.
Nawaz, F.
Cicala, C.
Van Ryk, D.
Wei, D.
Pascuccio, M.
Shrestha, S.
Knox, J.
Schwing, C.
Hiatt, J.
Chang, J.
Jelicic, K.
Fauci, A.
Arthos, J.
Fecek, R.
Mailliard, R.
Rinaldo, C.
Martinez-Maza, O.
Magpantay, L.
Phair, J.
Bream, J.H.
Rinaldo, C.R.
Jacobson, L.P.
Chahroudi, A.
Carnathan, D.
Carnathan, P.
Christ, F.
Pickford, C.
Demeulemeester, J.
Shaw, S.
Desimmie, B.A.
Smith-Burchnell, C.
Butler, S.
Westby, M.
Debyser, Z.
Johnson, T.
Clark, M.
Clark, J.
Shelke, N.
Friend, D.
Kiser, P.
Hofmann-Sieber, H.
Hauber, I.
Chemnitz, J.
Grundhoff, A.
Chusainow, J.
Schambach, A.
Baum, C.
Ziegler, P.
Manz, M.
Buchholz, F.
Hauber, J.
Kitchen, S.
Levin, B.
Rezek, V.
Kim, S.
Aguilera-Sandoval, C.
Balamurugan, A.
Yang, O.
Chang, L.-J.
Alkhatib, G.
Huang, L.-M.
Chen, Y.
Yeh, Y.
Dey, A.
Kassa, A.
Nandi, A.
Sarkar, P.
Sun, Y.
Hartog, K.
Labranche, C.
Montefiori, D.
Srivastava, I.
Carfi, A.
Barnett, S.
Gulzar, N.
Montero, M.
Klaric, K.-A.
Lepik, C.
Donald, J.
Tsai, S.
Wu, S.
Wang, S.
Degrado, W.
Lu, S.
Scott, J.K.
Tang, D.
Capina, R.
Yuan, X.-Y.
Prego, C.
Pinto, J.C.
Alonso, M.
Barry, C.
Pilon, R.
Daniuk, C.
Tuff, J.
Pillet, S.
La, D.
Czarnecki, C.
Lacap, P.
Peters, H.
Wong, G.
Kimani, M.
Ball, T.
Sandstrom, P.
Kobinger, G.
Vaccari, M.
Cameron, M.
Liyanage, N.
Pegu, P.
Gordon, S.
Doster, M.
Sekaly, R.-P.
Franchini, G.
Tran Thi Thanh, H.
Van den Bergh, R.
Massinga-Loembe, M.
Colebunders, R.
De Baetselier, P.
Raes, G.
Santos-Oliveira, J.
Giacoia-Gripp, C.
Regis, E.
Alexandrino-Oliveira, P.
Amato, V.
Lindoso, J.A.
Goto, H.
Guerra, J.
Mattos, M.
Oliveira-Neto, M.
Grinzstejn, B.
Morgado, M.
Da-Cruz, A.
Tugizov, S.
Herrera, R.
Veluppillai, P.
Greenspan, D.
Palefsky, J.
Thaisri, H.
Moriuchi, M.
Tsuchiya, N.
Rojanawiwat, A.
Pathipvanich, P.
Sawanpanyalert, P.
Ariyoshi, K.
Moriuchi, H.
Fitzgerald, W.
Ngwende, S.
Mudenge, B.
Madzimure, D.
Mudenge, G.
Pokaż więcej
Temat :
AIDS2012 Abstract Supplement
A4 - Bioinformatic analysis of viral diversity in natural
A7 - Virus-specific humoral immunity
A8 - Virus-specific cellular immunity
A9 - Immune responses in resistant cohorts: elite controlers and exposed uninfected
A10 - Mucosal immunity/defenses: responses and dysfunction
A12 - Mechanisms of activation / inflammation and impact in pathogenesis
A13 - Mechanisms of T cell depletion and dysfunction
A14 - Pathogenesis in gut, lymphoid tissues and bone marrow
A23 - Regulation of gene expression and latency
A25 - Cellular elements necessary for HIV replication
A27 - Viral mechanisms of persistence and latency
A28 - Mechanisms of eradication
A29 - Tissue reservoirs
A30 - Host cellular factors and latency
A31 - Host genetics of resistance and susceptibility
A32 - Host restriction factors including APOBEC, TRIM and others
A33 - Systems biology approaches to HIV infection
A34 - Mucosal transmission
A36 - Acute and early HIV infection
A37 - Highly exposed seronegative individuals (HESN)
A38 - Mother-to-child transmission
A39 - Preclinical HIV drug development
A40 - Preclinical development of microbicides
A42 - Nucleic acid-based HIV and SIV therapies
A43 - B cell-based vaccines
A44 - T cell-based vaccines
A45 - Novel vectors and strategies
A53 - Mycobacteria and tuberculosis
A55 - Interactions with other pathogens
A56 - Novel assays of immune responses
A57 - Novel assays for virological monitoring
Źródło :
Journal of the International AIDS Society
Tytuł :
Downregulation of Robust Acute Type I Interferon Responses Distinguishes Nonpathogenic Simian Immunodeficiency Virus (SIV) Infection of Natural Hosts from Pathogenic SIV Infection of Rhesus Macaques
Autorzy :
Harris, L.
Tabb, B.
Sodora, D
Paiardini, M.
Klatt, N.
Douek, D.
Silvestri, G.
Müller-Trutwin, M.
Vasile-Pandrea, I.
Apetrei, C.
Hirsch, V.
Lifson, J.
Brenchley, J
Estes, J
Pokaż więcej
Temat :
[SDV]Life Sciences [q-bio]
[SDV.IMM]Life Sciences [q-bio]/Immunology
[SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
Źródło :
Journal of Virology, American Society for Microbiology, 2010, 84 (15), pp.7886-7891. ⟨10.1128/jvi.02612-09⟩
Tytuł :
Administration of Fludarabine-Loaded Autologous Red Blood Cells in Simian Immunodeficiency Virus-Infected Sooty Mangabeys Depletes pSTAT-1-Expressing Macrophages and Delays the Rebound of Viremia after Suspension of Antiretroviral Therapy
Autorzy :
Cervasi, B.
Paiardini, M.
Serafini, S.
Fraternale, A.
Menotta, M.
Engram, J.
Lawson, B.
Staprans, S. I.
Piedimonte, G.
Perno, C. F.
Silvestri, G.
Magnani, M.
Pokaż więcej
Temat :
Vaccines and Antiviral Agents

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