Preferential selection of viral escape mutants by CD8+ T cell 'sieving' of SIV reactivation from latency.
Autorzy:
Docken SS; Infection Analytics Program, Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia. McCormick K; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America. Pampena MB; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.; Center for AIDS Research and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America. Samer S; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America. Lindemuth E; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America. Pinkevych M; Infection Analytics Program, Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia. Viox EG; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America. Wu Y; Infection Analytics Program, Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia. Schlub TE; Sydney School of Public Health, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia. Cromer D; Infection Analytics Program, Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia. Keele BF; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America. PaiardiniM; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, Georgia, United States of America. Betts MR; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.; Center for AIDS Research and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America. Bar KJ; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America. Davenport MP; Infection Analytics Program, Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.
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Źródło:
PLoS pathogens [PLoS Pathog] 2023 Nov 30; Vol. 19 (11), pp. e1011755. Date of Electronic Publication: 2023 Nov 30 (Print Publication: 2023).
Timing of initiation of anti-retroviral therapy predicts post-treatment control of SIV replication.
Autorzy:
Pinkevych M; Infection Analytics Program, Kirby Institute for Infection and Immunity, UNSW Australia, Sydney, New South Wales, Australia. Docken SS; Infection Analytics Program, Kirby Institute for Infection and Immunity, UNSW Australia, Sydney, New South Wales, Australia. Okoye AA; Vaccine & Gene Therapy Institute, and Oregon National Primate Research Center, Beaverton, Oregon, United States of America. Fennessey CM; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America. Del Prete GQ; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America. Pino M; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America. Harper JL; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America. Betts MR; Department of Microbiology and Center for AIDS Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America. PaiardiniM; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.; Department of Pathology and Laboratory Medicine, School of Medicine; Emory University, Atlanta, Georgia, United States of America. Keele BF; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America. Davenport MP; Infection Analytics Program, Kirby Institute for Infection and Immunity, UNSW Australia, Sydney, New South Wales, Australia.
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Źródło:
PLoS pathogens [PLoS Pathog] 2023 Oct 06; Vol. 19 (10), pp. e1011660. Date of Electronic Publication: 2023 Oct 06 (Print Publication: 2023).
Chronic immune activation and gut barrier dysfunction is associated with neuroinflammation in ART-suppressed SIV+ rhesus macaques.
Autorzy:
Byrnes SJ; School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia. Busman-Sahay K; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, United States of America.; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health & Science University, Portland, Oregon, United States of America. Angelovich TA; School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia.; Life Science, Burnet Institute, Melbourne, Australia.; Department of Infectious Diseases, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Australia. Younger S; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, United States of America. Taylor-Brill S; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, United States of America. Nekorchuk M; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, United States of America. Bondoc S; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, United States of America. Dannay R; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, United States of America. Terry M; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, United States of America. Cochrane CR; School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia. Jenkins TA; School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia. Roche M; School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia.; Department of Infectious Diseases, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Australia. Deleage C; AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America. Bosinger SE; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America. PaiardiniM; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America. Brew BJ; Peter Duncan Neurosciences Unit, Departments of Neurology and Immunology St Vincent's Hospital, University of New South Wales and University of Notre Dame, Sydney, New South Wales, Australia. Estes JD; School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia.; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, United States of America.; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health & Science University, Portland, Oregon, United States of America. Churchill MJ; School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia.; Life Science, Burnet Institute, Melbourne, Australia.; Departments of Microbiology and Medicine, Monash University, Clayton, Australia.
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Źródło:
PLoS pathogens [PLoS Pathog] 2023 Mar 29; Vol. 19 (3), pp. e1011290. Date of Electronic Publication: 2023 Mar 29 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, N.I.H., Intramural; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
PP 8.7 – 00098 The sequestration and expansion of effector lymphocytes in lymphoid tissue using combination FTY720 and N-803 immunotherapy at ART initiation fails to limit SIV persistence
PP 4.23 – 00148 Inhibition of the GSK3 pathway enhances CD8+ T cell stemness and functional capacities without promoting non-cytolytic suppression of HIV transcription
The role of CD101-expressing CD4 T cells in HIV/SIV pathogenesis and persistence.
Autorzy:
Strongin Z; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University; Atlanta, Georgia, United States of America. Hoang TN; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University; Atlanta, Georgia, United States of America. Tharp GK; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University; Atlanta, Georgia, United States of America. Rahmberg AR; Barrier Immunity Section, Laboratory of Viral Diseases, NIAID, NIH; Bethesda, Maryland, United States of America. Harper JL; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University; Atlanta, Georgia, United States of America. Nguyen K; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University; Atlanta, Georgia, United States of America. Franchitti L; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University; Atlanta, Georgia, United States of America. Cervasi B; Flow Cytometry Core, Emory Vaccine Center, Emory University; Atlanta, Georgia, United States of America. Lee M; Vaccine Research Center, National Institutes of Health; Bethesda, Maryland, United States of America. Zhang Z; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University; Atlanta, Georgia, United States of America. Boritz EA; Vaccine Research Center, National Institutes of Health; Bethesda, Maryland, United States of America. Silvestri G; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University; Atlanta, Georgia, United States of America.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine; Atlanta, Georgia, United States of America.; Division of Infectious Diseases, Emory University School of Medicine; Atlanta, Georgia, United States of America. Marconi VC; Division of Infectious Diseases, Emory University School of Medicine; Atlanta, Georgia, United States of America.; Division of Infectious Diseases Research, Atlanta Veterans Affairs Medical Center; Atlanta, Georgia, United States of America.; Rollins School of Public Health, Emory University; Atlanta, Georgia, United States of America.; Emory Vaccine Center, Atlanta, Georgia, United States of America. Bosinger SE; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University; Atlanta, Georgia, United States of America.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine; Atlanta, Georgia, United States of America. Brenchley JM; Barrier Immunity Section, Laboratory of Viral Diseases, NIAID, NIH; Bethesda, Maryland, United States of America. Kulpa DA; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University; Atlanta, Georgia, United States of America.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine; Atlanta, Georgia, United States of America. PaiardiniM; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University; Atlanta, Georgia, United States of America.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine; Atlanta, Georgia, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2022 Jul 22; Vol. 18 (7), pp. e1010723. Date of Electronic Publication: 2022 Jul 22 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
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