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Tytuł:
Alveolar macrophages from EVALI patients and e-cigarette users: a story of shifting phenotype.
Autorzy:
Warren KJ; Department of Internal Medicine, Division of Pulmonary & Critical Care Medicine, University of Utah, Salt Lake City, UT, 84132, USA. .; George E. Wahlen VA Medical Center, 500 Foothill Dr, Salt Lake City, UT, 84148, USA. .
Beck EM; Department of Internal Medicine, Division of Pulmonary & Critical Care Medicine, University of Utah, Salt Lake City, UT, 84132, USA.; George E. Wahlen VA Medical Center, 500 Foothill Dr, Salt Lake City, UT, 84148, USA.
Callahan SJ; Department of Internal Medicine, Division of Pulmonary & Critical Care Medicine, University of Utah, Salt Lake City, UT, 84132, USA.; George E. Wahlen VA Medical Center, 500 Foothill Dr, Salt Lake City, UT, 84148, USA.
Helms MN; Department of Internal Medicine, Division of Pulmonary & Critical Care Medicine, University of Utah, Salt Lake City, UT, 84132, USA.
Middleton E; Department of Internal Medicine, Division of Pulmonary & Critical Care Medicine, University of Utah, Salt Lake City, UT, 84132, USA.
Maddock S; George E. Wahlen VA Medical Center, 500 Foothill Dr, Salt Lake City, UT, 84148, USA.; Division of Pulmonary and Critical Care Medicine, National Jewish Health, Denver, CO, 80206, USA.
Carr JR; Department of Internal Medicine, Division of Pulmonary & Critical Care Medicine, University of Utah, Salt Lake City, UT, 84132, USA.; Intermountain Healthcare, Department of Pulmonary & Critical Care Medicine, Murray, UT, 84107, USA.
Harris D; Intermountain Healthcare, Department of Pulmonary & Critical Care Medicine, Murray, UT, 84107, USA.
Blagev DP; Intermountain Healthcare, Department of Pulmonary & Critical Care Medicine, Murray, UT, 84107, USA.
Lanspa MJ; Intermountain Healthcare, Department of Pulmonary & Critical Care Medicine, Murray, UT, 84107, USA.
Brown SM; Intermountain Healthcare, Department of Pulmonary & Critical Care Medicine, Murray, UT, 84107, USA.
Paine R 3rd; Department of Internal Medicine, Division of Pulmonary & Critical Care Medicine, University of Utah, Salt Lake City, UT, 84132, USA.; George E. Wahlen VA Medical Center, 500 Foothill Dr, Salt Lake City, UT, 84148, USA.
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Źródło:
Respiratory research [Respir Res] 2023 Jun 17; Vol. 24 (1), pp. 162. Date of Electronic Publication: 2023 Jun 17.
Typ publikacji:
Journal Article
MeSH Terms:
Lung Injury*
Electronic Nicotine Delivery Systems*
Biological Products*
Humans ; Macrophages, Alveolar ; Phenotype ; Cytokines
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A blood and bronchoalveolar lavage protein signature of rapid FEV 1 decline in smoking-associated COPD.
Autorzy:
DiLillo KM; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Norman KC; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Freeman CM; Research Service, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA.; Division of Pulmonary & Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA.; Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, USA.
Christenson SA; Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California San Francisco, San Francisco, CA, USA.
Alexis NE; Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Anderson WH; Marsico Lung Institute/Pulmonary and Critical Care Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Barjaktarevic IZ; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Barr RG; Department of Medicine, Columbia University Medical Center, New York, NY, USA.
Comellas AP; Division of Pulmonary, Critical Care and Occupational Medicine, University of Iowa, Iowa City, IA, USA.
Bleecker ER; Division of Genetics, Genomics and Precision Medicine, University of Arizona Health Sciences, Tucson, AZ, USA.
Boucher RC; Marsico Lung Institute/Cystic Fibrosis Research Center, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Couper DJ; Collaborative Studies Coordinating Center, Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Criner GJ; Department of Thoracic Medicine and Surgery, Temple University, Philadelphia, PA, USA.
Doerschuk CM; Marsico Lung Institute/Cystic Fibrosis Research Center, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Wells JM; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Han MK; Division of Pulmonary & Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA.
Hoffman EA; Department of Radiology, University of Iowa, Iowa City, IA, USA.
Hansel NN; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Hastie AT; Department of Internal Medicine, Wake Forest School of Medicine, Atrium Health, Wake Forest Baptist, Winston Salem, NC, USA.
Kaner RJ; Department of Medicine, Weill Cornell Medical Center, New York, NY, USA.
Krishnan JA; Division of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois at Chicago, Chicago, IL, USA.
Labaki WW; Division of Pulmonary & Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA.
Martinez FJ; Department of Medicine, Weill Cornell Medical Center, New York, NY, USA.
Meyers DA; Division of Genetics, Genomics and Precision Medicine, University of Arizona Health Sciences, Tucson, AZ, USA.
O'Neal WK; Marsico Lung Institute/Cystic Fibrosis Research Center, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Ortega VE; Department of Internal Medicine, Division of Respiratory Medicine, Mayo Clinic, Scottsdale, AZ, USA.
Paine R 3rd; Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine, University of Utah, Salt Lake City, UT, USA.
Peters SP; Department of Internal Medicine, Wake Forest School of Medicine, Atrium Health, Wake Forest Baptist, Winston Salem, NC, USA.
Woodruff PG; Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California San Francisco, San Francisco, CA, USA.
Cooper CB; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Bowler RP; Division of Pulmonary and Critical Care, National Jewish Health, Denver, CO, USA.
Curtis JL; Division of Pulmonary & Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA.; Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, USA.; Medical Service, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA.
Arnold KB; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA. .
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Corporate Authors:
SPIROMICS investigators
Źródło:
Scientific reports [Sci Rep] 2023 May 22; Vol. 13 (1), pp. 8228. Date of Electronic Publication: 2023 May 22.
Typ publikacji:
Journal Article
MeSH Terms:
Lung*
Pulmonary Disease, Chronic Obstructive*
Humans ; Disease Progression ; Smoking/adverse effects ; Forced Expiratory Volume ; Bronchoalveolar Lavage ; Biomarkers
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Steady-state estradiol triggers a unique innate immune response to allergen resulting in increased airway resistance.
Autorzy:
Warren KJ; George E Wahlen Salt Lake City VA Medical Center, 500 Foothill Dr., Salt Lake City, UT, USA. .; The Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA. .; Division of Allergy and Immunology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA. .
Deering-Rice C; Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT, USA.
Huecksteadt T; George E Wahlen Salt Lake City VA Medical Center, 500 Foothill Dr., Salt Lake City, UT, USA.
Trivedi S; George E Wahlen Salt Lake City VA Medical Center, 500 Foothill Dr., Salt Lake City, UT, USA.; The Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.; Division of Allergy and Immunology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Venosa A; Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT, USA.
Reilly C; Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT, USA.
Sanders K; George E Wahlen Salt Lake City VA Medical Center, 500 Foothill Dr., Salt Lake City, UT, USA.; The Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.; Division of Allergy and Immunology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Clayton F; Department of Pathology, University of Utah, Salt Lake City, UT, USA.
Wyatt TA; Division of Allergy and Immunology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.; Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE, USA.
Poole JA; Division of Allergy and Immunology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Heller NM; Department of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, USA.
Leung D; The Division of Infectious Diseases, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
Paine R 3rd; George E Wahlen Salt Lake City VA Medical Center, 500 Foothill Dr., Salt Lake City, UT, USA.; The Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
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Źródło:
Biology of sex differences [Biol Sex Differ] 2023 Jan 06; Vol. 14 (1), pp. 2. Date of Electronic Publication: 2023 Jan 06.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Interleukin-33*/therapeutic use
Asthma*/drug therapy
Asthma*/metabolism
Female ; Animals ; Mice ; Estradiol/pharmacology ; Estradiol/therapeutic use ; Immunity, Innate ; Interleukin-13/therapeutic use ; Methacholine Chloride/pharmacology ; Methacholine Chloride/therapeutic use ; Allergens/therapeutic use ; Airway Resistance ; Interleukin-5/therapeutic use ; Bronchoalveolar Lavage Fluid ; Lymphocytes/metabolism ; Lymphocytes/pathology ; Lung/metabolism ; Cytokines ; Estrogens/therapeutic use
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Hypoxia induces expression of angiotensin-converting enzyme II in alveolar epithelial cells: Implications for the pathogenesis of acute lung injury in COVID-19.
Autorzy:
Sturrock A; Department of Veterans Affairs Medical Center, Salt Lake City, Utah, USA.; Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Zimmerman E; Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Helms M; Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Liou TG; Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Paine R 3rd; Department of Veterans Affairs Medical Center, Salt Lake City, Utah, USA.; Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.
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Źródło:
Physiological reports [Physiol Rep] 2021 May; Vol. 9 (9), pp. e14854.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Gene Expression Regulation, Enzymologic*
Acute Lung Injury/*enzymology
Alveolar Epithelial Cells/*enzymology
Angiotensin-Converting Enzyme 2/*biosynthesis
COVID-19/*enzymology
Hypoxia/*enzymology
Acute Lung Injury/genetics ; Angiotensin-Converting Enzyme 2/genetics ; Animals ; COVID-19/genetics ; Cells, Cultured ; Female ; Humans ; Hypoxia/genetics ; Male ; Mice ; Mice, Inbred C57BL
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Association of plasma mitochondrial DNA with COPD severity and progression in the SPIROMICS cohort.
Autorzy:
Zhang WZ; Division of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA.; Weill Cornell Medicine, New York-Presbyterian Hospital, New York, NY, USA.
Hoffman KL; Department of Population Health Science, Division of Biostatistics and Epidemiology, Weill Cornell Medicine, New York, NY, USA.
Schiffer KT; Division of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Oromendia C; Department of Population Health Science, Division of Biostatistics and Epidemiology, Weill Cornell Medicine, New York, NY, USA.
Rice MC; Division of Nephrology and Hypertension, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Barjaktarevic I; Division of Pulmonary and Critical Care Medicine, University of California Los Angeles Medical Center, Los Angeles, CA, USA.
Peters SP; Pulmonary, Critical Care, Allergy, and Immunologic Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Putcha N; Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Bowler RP; Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO, USA.
Wells JM; University of Alabama at Birmingham, Birmingham, AL, USA.
Couper DJ; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Labaki WW; Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, MI, USA.
Curtis JL; Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, MI, USA.
Han MK; Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, MI, USA.
Paine R 3rd; Section of Pulmonary and Critical Care Medicine, Salt Lake City Department of Veterans Affairs Medical Center, Salt Lake City, UT, USA.
Woodruff PG; University of California at San Francisco, San Francisco, CA, USA.
Criner GJ; Department of Pulmonary & Critical Care Medicine, Temple University, Philadelphia, PA, USA.
Hansel NN; Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Diaz I; Department of Population Health Science, Division of Biostatistics and Epidemiology, Weill Cornell Medicine, New York, NY, USA.
Ballman KV; Department of Population Health Science, Division of Biostatistics and Epidemiology, Weill Cornell Medicine, New York, NY, USA.
Nakahira K; Division of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Choi ME; Weill Cornell Medicine, New York-Presbyterian Hospital, New York, NY, USA.; Division of Nephrology and Hypertension, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Martinez FJ; Division of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA.; Weill Cornell Medicine, New York-Presbyterian Hospital, New York, NY, USA.
Choi AMK; Division of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA.; Weill Cornell Medicine, New York-Presbyterian Hospital, New York, NY, USA.
Cloonan SM; Division of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA. .; School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland and Tallaght University Hospital, Dublin, Ireland. .; Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, USA. .
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Źródło:
Respiratory research [Respir Res] 2021 Apr 26; Vol. 22 (1), pp. 126. Date of Electronic Publication: 2021 Apr 26.
Typ publikacji:
Journal Article; Multicenter Study; Observational Study
MeSH Terms:
DNA, Mitochondrial/*genetics
NADH Dehydrogenase/*genetics
Pulmonary Disease, Chronic Obstructive/*genetics
Aged ; DNA, Mitochondrial/blood ; Disease Progression ; Exercise Tolerance ; Female ; Forced Expiratory Volume ; Humans ; Longitudinal Studies ; Lung/physiopathology ; Male ; Middle Aged ; NADH Dehydrogenase/blood ; Prospective Studies ; Pulmonary Disease, Chronic Obstructive/blood ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Severity of Illness Index ; Smokers ; Smoking/adverse effects ; Surveys and Questionnaires ; Time Factors ; United States ; Walk Test
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Latent traits of lung tissue patterns in former smokers derived by dual channel deep learning in computed tomography images.
Autorzy:
Li F; Department of Biomedical Engineering, University of Iowa, Iowa City, IA, USA.; IIHR-Hydroscience and Engineering, 2406 Seamans Center for the Engineering Art and Science, University of Iowa, Iowa City, IA, 52242, USA.
Choi J; Department of Mechanical Engineering, University of Iowa, Iowa City, IA, USA.; Department of Internal Medicine, School of Medicine, University of Kansas, Kansas City, KS, USA.
Zou C; IIHR-Hydroscience and Engineering, 2406 Seamans Center for the Engineering Art and Science, University of Iowa, Iowa City, IA, 52242, USA.; Department of Mechanical Engineering, University of Iowa, Iowa City, IA, USA.
Newell JD Jr; Department of Radiology, University of Iowa, Iowa City, IA, USA.
Comellas AP; Department of Internal Medicine, University of Iowa, Iowa City, IA, USA.
Lee CH; Department of Radiology, University of Iowa, Iowa City, IA, USA.; Department of Radiology, Seoul National University, Seoul, Republic of Korea.
Ko H; Department of Radiology, Chungnam National University Sejong Hospital, Sejong, Republic of Korea.
Barr RG; Mailman School of Public Health, Columbia University, New York, NY, USA.
Bleecker ER; Department of Medicine, University of Arizona, Tucson, AZ, USA.
Cooper CB; Department of Physiology, UCLA, Los Angeles, CA, USA.
Abtin F; Department of Medicine, UCLA, Los Angeles, CA, USA.
Barjaktarevic I; Department of Medicine, UCLA, Los Angeles, CA, USA.
Couper D; Department of Biostatistics, University of North Carolina, Chapel Hill, NC, USA.
Han M; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Hansel NN; School of Medicine, Johns Hopkins, Baltimore, MD, USA.
Kanner RE; School of Medicine, University of Utah, Salt Lake City, UT, USA.
Paine R 3rd; School of Medicine, University of Utah, Salt Lake City, UT, USA.
Kazerooni EA; Department of Radiology, University of Michigan, Ann Arbor, MI, USA.
Martinez FJ; Weill Cornell Medicine, Cornell University, New York, NY, USA.
O'Neal W; School of Medicine, University of North Carolina, Chapel Hill, NC, USA.
Rennard SI; Department of Internal Medicine, University of Nebraska College of Medicine, Omaha, NE, USA.
Smith BM; Department of Medicine, Columbia University, New York, NY, USA.; Research Institute, McGill University Health Center, Montreal, Canada.
Woodruff PG; School of Medicine, UCSF, San Francisco, CA, USA.
Hoffman EA; Department of Biomedical Engineering, University of Iowa, Iowa City, IA, USA.; Department of Radiology, University of Iowa, Iowa City, IA, USA.; Department of Internal Medicine, University of Iowa, Iowa City, IA, USA.
Lin CL; Department of Biomedical Engineering, University of Iowa, Iowa City, IA, USA. .; IIHR-Hydroscience and Engineering, 2406 Seamans Center for the Engineering Art and Science, University of Iowa, Iowa City, IA, 52242, USA. .; Department of Mechanical Engineering, University of Iowa, Iowa City, IA, USA. .; Department of Radiology, University of Iowa, Iowa City, IA, USA. .
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Źródło:
Scientific reports [Sci Rep] 2021 Mar 01; Vol. 11 (1), pp. 4916. Date of Electronic Publication: 2021 Mar 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Lung*/diagnostic imaging
Lung*/pathology
Pulmonary Disease, Chronic Obstructive/*diagnostic imaging
Tomography, X-Ray Computed/*methods
Adult ; Aged ; Case-Control Studies ; Cohort Studies ; Female ; Humans ; Male ; Middle Aged ; Smokers
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
SARS-CoV-2 innate effector associations and viral load in early nasopharyngeal infection.
Autorzy:
Liou TG; Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT, USA.; Center for Quantitative Biology, University of Utah, Salt Lake City, UT, USA.
Adler FR; Center for Quantitative Biology, University of Utah, Salt Lake City, UT, USA.; Department of Mathematics and School of Biological Sciences, University of Utah, Salt Lake City, UT, USA.
Cahill BC; Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT, USA.
Cox DR; Nuffield College, Oxford, UK.
Cox JE; Department of Biochemistry, School of Medicine, University of Utah, Salt Lake City, UT, USA.; Metabolomics, Proteomics and Mass Spectrometry Core, School of Medicine, University of Utah, Salt Lake City, UT, USA.
Grant GJ; Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT, USA.
Hanson KE; Division of Infectious Diseases, Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT, USA.; Department of Pathology, University of Utah, Salt Lake City, UT, USA.; ARUP Laboratories, Salt Lake City, UT, USA.
Hartsell SC; Division of Emergency Medicine, Department of Surgery, University of Utah, Salt Lake City, UT, USA.
Hatton ND; Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT, USA.
Helms MN; Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT, USA.
Jensen JL; Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT, USA.
Kartsonaki C; Clinical Trial Service Unit & Epidemiological Studies Unit and Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Li Y; Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT, USA.
Leung DT; Division of Infectious Diseases, Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT, USA.
Marvin JE; Flow Cytometry Core Laboratory, University of Utah Health, Salt Lake City, UT, USA.
Middleton EA; Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT, USA.
Osburn-Staker SM; Metabolomics, Proteomics and Mass Spectrometry Core, School of Medicine, University of Utah, Salt Lake City, UT, USA.
Packer KA; Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT, USA.
Shakir SM; Department of Pathology, University of Utah, Salt Lake City, UT, USA.; ARUP Laboratories, Salt Lake City, UT, USA.
Sturrock AB; Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT, USA.
Tardif KD; ARUP Laboratories, Salt Lake City, UT, USA.
Warren KJ; Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT, USA.; Department of Veterans Affairs Medical Center, Salt Lake City, UT, USA.
Waddoups LJ; Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT, USA.
Weaver LJ; Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT, USA.
Zimmerman E; Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT, USA.
Paine R 3rd; Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT, USA.; Department of Veterans Affairs Medical Center, Salt Lake City, UT, USA.
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Źródło:
Physiological reports [Physiol Rep] 2021 Feb; Vol. 9 (4), pp. e14761.
Typ publikacji:
Journal Article; Observational Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
COVID-19/*immunology
Immunity, Innate/*immunology
Nasopharyngeal Diseases/*virology
SARS-CoV-2/*immunology
Viral Load/*immunology
Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; COVID-19/virology ; Child ; Cytokines/blood ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Male ; Middle Aged ; Nasopharyngeal Diseases/immunology ; RNA, Messenger/genetics ; Real-Time Polymerase Chain Reaction ; SARS-CoV-2/genetics ; Sex Factors ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Current smoking with or without chronic bronchitis is independently associated with goblet cell hyperplasia in healthy smokers and COPD subjects.
Autorzy:
Kim V; Lewis Katz School of Medicine at Temple University, 3401 North Broad Street, 785 Parkinson Pavilion, Philadelphia, PA, 19140, USA. .
Jeong S; Lewis Katz School of Medicine at Temple University, 3401 North Broad Street, 785 Parkinson Pavilion, Philadelphia, PA, 19140, USA.
Zhao H; Lewis Katz School of Medicine at Temple University, 3401 North Broad Street, 785 Parkinson Pavilion, Philadelphia, PA, 19140, USA.
Kesimer M; University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Boucher RC; University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Wells JM; University of Alabama at Birmingham, Birmingham, AL, USA.
Christenson SA; University of California San Francisco, San Francisco, CA, USA.
Han MK; University of Michigan School of Medicine, Ann Arbor, MI, USA.
Dransfield M; University of Alabama at Birmingham, Birmingham, AL, USA.
Paine R 3rd; University of Utah Health, Salt Lake City, UT, USA.
Cooper CB; David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Barjaktarevic I; David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Bowler R; National Jewish Health, Denver, CO, USA.
Curtis JL; University of Michigan Health Care System, Ann Arbor, MI, USA.
Kaner RJ; Weill Cornell Medical College, New York, NY, USA.
O'Beirne SL; Weill Cornell Medical College, New York, NY, USA.
O'Neal WK; University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Rennard SI; University of Nebraska Medical Center, Omaha, NE, USA.
Martinez FJ; Weill Cornell Medical College, New York, NY, USA.
Woodruff PG; University of California San Francisco, San Francisco, CA, USA.
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Źródło:
Scientific reports [Sci Rep] 2020 Nov 18; Vol. 10 (1), pp. 20133. Date of Electronic Publication: 2020 Nov 18.
Typ publikacji:
Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Bronchitis, Chronic/*pathology
Goblet Cells/*pathology
Pulmonary Disease, Chronic Obstructive/*pathology
Smoking/*pathology
Aged ; Female ; Humans ; Hyperplasia/pathology ; Logistic Models ; Male ; Middle Aged ; Prospective Studies ; Smokers
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Increased airway iron parameters and risk for exacerbation in COPD: an analysis from SPIROMICS.
Autorzy:
Zhang WZ; Joan and Sanford I. Weill Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, USA.; New York-Presbyterian Hospital, New York, New York, USA.; SPIROMICS investigators, Collaborative Studies Coordinating Center, Department of Biostatistics Gillings School of Global Public Health, University of North Carolina at Chapel Hill 123 W. Franklin Street Suite 450, Chapel Hill, NC 27516, USA.
Oromendia C; Joan and Sanford I. Weill Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, USA.; Department of Population Health Sciences, Division of Biostatistics, Weill Cornell Medicine, New York, New York, USA.
Kikkers SA; Joan and Sanford I. Weill Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, USA.
Butler JJ; Joan and Sanford I. Weill Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, USA.
O'Beirne S; Joan and Sanford I. Weill Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, USA.; Department of Genetic Medicine, Weill Cornell Medicine, New York, New York, USA.; SPIROMICS investigators, Collaborative Studies Coordinating Center, Department of Biostatistics Gillings School of Global Public Health, University of North Carolina at Chapel Hill 123 W. Franklin Street Suite 450, Chapel Hill, NC 27516, USA.
Kim K; Joan and Sanford I. Weill Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, USA.
O'Neal WK; University of North Carolina Marsico Lung Institute, Chapel Hill, North Carolina, USA.; SPIROMICS investigators, Collaborative Studies Coordinating Center, Department of Biostatistics Gillings School of Global Public Health, University of North Carolina at Chapel Hill 123 W. Franklin Street Suite 450, Chapel Hill, NC 27516, USA.
Freeman CM; Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, USA.; Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan, USA.; SPIROMICS investigators, Collaborative Studies Coordinating Center, Department of Biostatistics Gillings School of Global Public Health, University of North Carolina at Chapel Hill 123 W. Franklin Street Suite 450, Chapel Hill, NC 27516, USA.
Christenson SA; University of California at San Francisco, San Francisco, California, USA.; SPIROMICS investigators, Collaborative Studies Coordinating Center, Department of Biostatistics Gillings School of Global Public Health, University of North Carolina at Chapel Hill 123 W. Franklin Street Suite 450, Chapel Hill, NC 27516, USA.
Peters SP; Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; SPIROMICS investigators, Collaborative Studies Coordinating Center, Department of Biostatistics Gillings School of Global Public Health, University of North Carolina at Chapel Hill 123 W. Franklin Street Suite 450, Chapel Hill, NC 27516, USA.
Wells JM; Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama, UK.; SPIROMICS investigators, Collaborative Studies Coordinating Center, Department of Biostatistics Gillings School of Global Public Health, University of North Carolina at Chapel Hill 123 W. Franklin Street Suite 450, Chapel Hill, NC 27516, USA.
Doerschuk C; University of North Carolina Marsico Lung Institute, Chapel Hill, North Carolina, USA.; SPIROMICS investigators, Collaborative Studies Coordinating Center, Department of Biostatistics Gillings School of Global Public Health, University of North Carolina at Chapel Hill 123 W. Franklin Street Suite 450, Chapel Hill, NC 27516, USA.
Putcha N; Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; SPIROMICS investigators, Collaborative Studies Coordinating Center, Department of Biostatistics Gillings School of Global Public Health, University of North Carolina at Chapel Hill 123 W. Franklin Street Suite 450, Chapel Hill, NC 27516, USA.
Barjaktarevic I; Division of Pulmonary and Critical Care Medicine, University of California Los Angeles Medical Center, Los Angeles, California, USA.; SPIROMICS investigators, Collaborative Studies Coordinating Center, Department of Biostatistics Gillings School of Global Public Health, University of North Carolina at Chapel Hill 123 W. Franklin Street Suite 450, Chapel Hill, NC 27516, USA.
Woodruff PG; University of California at San Francisco, San Francisco, California, USA.; SPIROMICS investigators, Collaborative Studies Coordinating Center, Department of Biostatistics Gillings School of Global Public Health, University of North Carolina at Chapel Hill 123 W. Franklin Street Suite 450, Chapel Hill, NC 27516, USA.
Cooper CB; Division of Pulmonary and Critical Care Medicine, University of California Los Angeles Medical Center, Los Angeles, California, USA.; SPIROMICS investigators, Collaborative Studies Coordinating Center, Department of Biostatistics Gillings School of Global Public Health, University of North Carolina at Chapel Hill 123 W. Franklin Street Suite 450, Chapel Hill, NC 27516, USA.
Bowler RP; University of Colorado School of Medicine, Aurora, Colorado, USA.; National Jewish Health, Denver, Colorado, USA.; SPIROMICS investigators, Collaborative Studies Coordinating Center, Department of Biostatistics Gillings School of Global Public Health, University of North Carolina at Chapel Hill 123 W. Franklin Street Suite 450, Chapel Hill, NC 27516, USA.
Comellas AP; Division of Pulmonary and Critical Care, University of Iowa, Iowa City, Iowa, USA.; SPIROMICS investigators, Collaborative Studies Coordinating Center, Department of Biostatistics Gillings School of Global Public Health, University of North Carolina at Chapel Hill 123 W. Franklin Street Suite 450, Chapel Hill, NC 27516, USA.
Criner GJ; Department of Pulmonary & Critical Care Medicine, Temple University, Philadelphia, Pennsylvania, USA.; SPIROMICS investigators, Collaborative Studies Coordinating Center, Department of Biostatistics Gillings School of Global Public Health, University of North Carolina at Chapel Hill 123 W. Franklin Street Suite 450, Chapel Hill, NC 27516, USA.
Paine R 3rd; Section of Pulmonary and Critical Care Medicine, Salt Lake City Department of Veterans Affairs Medical Center, Salt Lake City, Utah, USA.; SPIROMICS investigators, Collaborative Studies Coordinating Center, Department of Biostatistics Gillings School of Global Public Health, University of North Carolina at Chapel Hill 123 W. Franklin Street Suite 450, Chapel Hill, NC 27516, USA.
Hansel NN; Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; SPIROMICS investigators, Collaborative Studies Coordinating Center, Department of Biostatistics Gillings School of Global Public Health, University of North Carolina at Chapel Hill 123 W. Franklin Street Suite 450, Chapel Hill, NC 27516, USA.
Han MK; Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, USA.; SPIROMICS investigators, Collaborative Studies Coordinating Center, Department of Biostatistics Gillings School of Global Public Health, University of North Carolina at Chapel Hill 123 W. Franklin Street Suite 450, Chapel Hill, NC 27516, USA.
Crystal RG; Department of Genetic Medicine, Weill Cornell Medicine, New York, New York, USA.
Kaner RJ; Joan and Sanford I. Weill Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, USA.; Department of Genetic Medicine, Weill Cornell Medicine, New York, New York, USA.; SPIROMICS investigators, Collaborative Studies Coordinating Center, Department of Biostatistics Gillings School of Global Public Health, University of North Carolina at Chapel Hill 123 W. Franklin Street Suite 450, Chapel Hill, NC 27516, USA.
Ballman KV; Joan and Sanford I. Weill Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, USA.; Department of Population Health Sciences, Division of Biostatistics, Weill Cornell Medicine, New York, New York, USA.
Curtis JL; Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, USA.; Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan, USA.; SPIROMICS investigators, Collaborative Studies Coordinating Center, Department of Biostatistics Gillings School of Global Public Health, University of North Carolina at Chapel Hill 123 W. Franklin Street Suite 450, Chapel Hill, NC 27516, USA.
Martinez FJ; Joan and Sanford I. Weill Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, USA.; New York-Presbyterian Hospital, New York, New York, USA.; SPIROMICS investigators, Collaborative Studies Coordinating Center, Department of Biostatistics Gillings School of Global Public Health, University of North Carolina at Chapel Hill 123 W. Franklin Street Suite 450, Chapel Hill, NC 27516, USA.
Cloonan SM; Joan and Sanford I. Weill Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, USA. .; School of Medicine, Trinity Biomedical Sciences Institute and Tallaght University Hospital, Trinity College Dublin, Trinity, Ireland. .; SPIROMICS investigators, Collaborative Studies Coordinating Center, Department of Biostatistics Gillings School of Global Public Health, University of North Carolina at Chapel Hill 123 W. Franklin Street Suite 450, Chapel Hill, NC 27516, USA. .
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Źródło:
Scientific reports [Sci Rep] 2020 Jun 29; Vol. 10 (1), pp. 10562. Date of Electronic Publication: 2020 Jun 29.
Typ publikacji:
Clinical Trial; Journal Article; Multicenter Study; Observational Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Iron/*metabolism
Iron-Binding Proteins/*metabolism
Pulmonary Disease, Chronic Obstructive/*physiopathology
Adult ; Aged ; Aged, 80 and over ; Biomarkers/blood ; Bronchoalveolar Lavage Fluid/chemistry ; Disease Progression ; Female ; Ferritins/metabolism ; Forced Expiratory Volume ; Humans ; Iron/physiology ; Iron-Binding Proteins/physiology ; Lung/metabolism ; Male ; Middle Aged ; Pulmonary Disease, Chronic Obstructive/metabolism ; Respiratory Function Tests ; Risk Factors ; Severity of Illness Index
Czasopismo naukowe
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Tytuł:
Serum amino acid concentrations and clinical outcomes in smokers: SPIROMICS metabolomics study.
Autorzy:
Labaki WW; Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA. .
Gu T; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Murray S; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Curtis JL; Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA.; Medical Service, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA.
Yeomans L; Biochemical NMR Core and the NMR Metabolomics Laboratory, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA.
Bowler RP; Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO, USA.
Barr RG; Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University, New York, NY, USA.
Comellas AP; Division of Pulmonary, Critical Care and Occupational Medicine, University of Iowa, Iowa City, IA, USA.
Hansel NN; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA.
Cooper CB; Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Barjaktarevic I; Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Kanner RE; Division of Pulmonary Medicine, University of Utah, Salt Lake City, UT, USA.
Paine R 3rd; Division of Pulmonary Medicine, University of Utah, Salt Lake City, UT, USA.
McDonald MN; Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.; Department of Genetics, University of Alabama at Birmingham, Birmingham, AL, USA.
Krishnan JA; Division of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois at Chicago, Chicago, IL, USA.
Peters SP; Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University, Winston-Salem, NC, USA.
Woodruff PG; Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California San Francisco, San Francisco, CA, USA.
O'Neal WK; Marsico Lung Institute, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Diao W; Department of Respiratory Medicine, Peking University Third Hospital, Beijing, China.
He B; Department of Respiratory Medicine, Peking University Third Hospital, Beijing, China.
Martinez FJ; Division of Pulmonary and Critical Care Medicine, Weill Cornell Medical College, New York, NY, USA.
Standiford TJ; Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA.
Stringer KA; Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA.; Department of Clinical Pharmacy, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA.
Han MK; Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA.
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Źródło:
Scientific reports [Sci Rep] 2019 Aug 06; Vol. 9 (1), pp. 11367. Date of Electronic Publication: 2019 Aug 06.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Smokers*
Amino Acids/*blood
Pulmonary Disease, Chronic Obstructive/*blood
Female ; Humans ; Isoleucine/blood ; Leucine/blood ; Male ; Metabolomics ; Middle Aged ; Patient Outcome Assessment ; Proton Magnetic Resonance Spectroscopy ; Tryptophan/blood ; Valine/blood
Czasopismo naukowe
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Tytuł:
Imaging-based clusters in former smokers of the COPD cohort associate with clinical characteristics: the SubPopulations and intermediate outcome measures in COPD study (SPIROMICS).
Autorzy:
Haghighi B; Department of Mechanical Engineering, University of Iowa, Iowa City, Iowa, USA.; IIHR-Hydroscience & Engineering, University of Iowa, Iowa City, Iowa, USA.
Choi S; School of Mechanical Engineering, Kyungpook National University, Daegu, Republic of Korea.
Choi J; Department of Mechanical Engineering, University of Iowa, Iowa City, Iowa, USA.; IIHR-Hydroscience & Engineering, University of Iowa, Iowa City, Iowa, USA.
Hoffman EA; Department of Radiology, University of Iowa, Iowa City, Iowa, USA.; Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa, USA.; Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.
Comellas AP; Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.
Newell JD Jr; Department of Radiology, University of Iowa, Iowa City, Iowa, USA.
Lee CH; Department of Radiology, University of Iowa, Iowa City, Iowa, USA.; Department of Radiology, College of Medicine, Seoul National University, Seoul, Republic of Korea.
Barr RG; Department of Epidemiology, Mailman School of Public Health, Columbia University Medical School, New York, NY, USA.
Bleecker E; Department of Medicine, The University of Arizona, Tucson, AZ, USA.
Cooper CB; Department of Physiology, UCLA, Los Angeles, CA, USA.
Couper D; Department of Biostatistics, University of North Carolina, Chapel Hill, NC, USA.
Han ML; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Hansel NN; School of Medicine, Johns Hopkins, Baltimore, MD, USA.
Kanner RE; School of Medicine, University of Utah, Salt Lake City, UT, USA.
Kazerooni EA; Department of Radiology, University of Michigan, Ann Arbor, MI, USA.
Kleerup EAC; Department of Medicine, UCLA, Los Angeles, CA, USA.
Martinez FJ; Department of Medicine, Weill Cornell Medical Center, New York, NY, USA.
O'Neal W; School of Medicine, University of North Carolina, Chapel Hill, NC, USA.
Paine R 3rd; School of Medicine, University of Utah, Salt Lake City, UT, USA.
Rennard SI; Department of Internal Medicine, University of Nebraska College of Medicine, Omaha, NE, USA.; Clinical Discovery Unit, AstraZeneca, Cambridge, UK.
Smith BM; Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.; McGill University Health Center Research Institute, Montreal, Canada.
Woodruff PG; School of Medicine, UCSF, San Francisco, CA, USA.
Lin CL; Department of Mechanical Engineering, University of Iowa, Iowa City, Iowa, USA. .; IIHR-Hydroscience & Engineering, University of Iowa, Iowa City, Iowa, USA. .; Department of Radiology, University of Iowa, Iowa City, Iowa, USA. .; Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa, USA. .; 2406 Seamans Center for the Engineering Art and Science, Iowa City, Iowa, 52242, USA. .
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Źródło:
Respiratory research [Respir Res] 2019 Jul 15; Vol. 20 (1), pp. 153. Date of Electronic Publication: 2019 Jul 15.
Typ publikacji:
Journal Article
MeSH Terms:
Imaging, Three-Dimensional/*methods
Pulmonary Disease, Chronic Obstructive/*diagnostic imaging
Pulmonary Disease, Chronic Obstructive/*physiopathology
Smoking/*physiopathology
Tomography, X-Ray Computed/*methods
Aged ; Cohort Studies ; Cross-Sectional Studies ; Female ; Forced Expiratory Volume ; Humans ; Male ; Middle Aged ; Outcome Assessment, Health Care ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Smoking/epidemiology
Czasopismo naukowe
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Tytuł:
Heterogeneous burden of lung disease in smokers with borderline airflow obstruction.
Autorzy:
Pirozzi CS; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Utah, 26 N 1900 E, Salt Lake City, UT, 84132, USA. .
Gu T; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Quibrera PM; Department of Biostatistics, Collaborative Studies Coordinating Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Carretta EE; Department of Biostatistics, Collaborative Studies Coordinating Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Han MK; Department of Internal Medicine, University of Michigan, Ann, MI, USA.
Murray S; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Cooper CB; Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.
Tashkin DP; Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.
Kleerup EC; Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.
Barjaktarevic I; Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.
Hoffman EA; Department of Radiology, University of Iowa, Iowa City, IA, USA.
Martinez CH; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Christenson SA; Department of Medicine, University of California, San Francisco, CA, USA.
Hansel NN; Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Graham Barr R; Department of Medicine, Columbia University, New York, NY, USA.
Bleecker ER; Department of Medicine, University of Arizona, Tucson, AZ, USA.
Ortega VE; Department of Medicine, Wake Forest University, Winston-Salem, NC, USA.
Martinez FJ; Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Kanner RE; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Utah, 26 N 1900 E, Salt Lake City, UT, 84132, USA.
Paine R 3rd; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Utah, 26 N 1900 E, Salt Lake City, UT, 84132, USA.; Department of Veterans Affairs Medical Center, Salt Lake City, UT, USA.
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Corporate Authors:
NHLBI SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS)
Źródło:
Respiratory research [Respir Res] 2018 Nov 20; Vol. 19 (1), pp. 223. Date of Electronic Publication: 2018 Nov 20.
Typ publikacji:
Journal Article; Multicenter Study
MeSH Terms:
Cost of Illness*
Smokers*
Forced Expiratory Volume/*physiology
Lung Diseases/*diagnostic imaging
Lung Diseases/*physiopathology
Aged ; Cohort Studies ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Pulmonary Disease, Chronic Obstructive/diagnostic imaging ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Pulmonary Emphysema/diagnostic imaging ; Pulmonary Emphysema/physiopathology ; Spirometry/methods ; Vital Capacity/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Genome-wide association study of lung function and clinical implication in heavy smokers.
Autorzy:
Li X; Division of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, BioScience Research Lab, Room 253, 1230 N. Cherry Avenue, PO Box 210242, Tucson, AZ, 85721, USA. .
Ortega VE; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Ampleford EJ; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Graham Barr R; Department of Medicine, Columbia University, New York, NY, USA.
Christenson SA; Division of Pulmonary, Critical Care, Sleep & Allergy, Department of Medicine and Cardiovascular Research Institute, University of California at San Francisco, San Francisco, California, USA.
Cooper CB; Department of Medicine, University of California at Los Angeles, Los Angeles, California, USA.
Couper D; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Dransfield MT; Division of Pulmonary, Allergy & Critical Care Medicine, Lung Health Center, University of Alabama at Birmingham, Birmingham, AL, USA.
Han MLK; Division of Pulmonary & Critical Care, University of Michigan, Ann Arbor, MI, USA.
Hansel NN; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Hoffman EA; Department of Radiology, University of Iowa, Iowa City, Iowa, USA.
Kanner RE; Department of Internal Medicine/Pulmonary and Critical Care Medicine, University of Utah, Salt Lake City, UT, USA.
Kleerup EC; Department of Medicine, University of California at Los Angeles, Los Angeles, California, USA.
Martinez FJ; Department of Medicine, Weill Cornell Medical College of Cornell University, New York, NY, USA.
Paine R 3rd; Department of Internal Medicine/Pulmonary and Critical Care Medicine, University of Utah, Salt Lake City, UT, USA.
Woodruff PG; Division of Pulmonary, Critical Care, Sleep & Allergy, Department of Medicine and Cardiovascular Research Institute, University of California at San Francisco, San Francisco, California, USA.
Hawkins GA; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Bleecker ER; Division of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, BioScience Research Lab, Room 253, 1230 N. Cherry Avenue, PO Box 210242, Tucson, AZ, 85721, USA.
Meyers DA; Division of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, BioScience Research Lab, Room 253, 1230 N. Cherry Avenue, PO Box 210242, Tucson, AZ, 85721, USA.
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Corporate Authors:
SPIROMICS Research Group
Źródło:
BMC medical genetics [BMC Med Genet] 2018 Aug 01; Vol. 19 (1), pp. 134. Date of Electronic Publication: 2018 Aug 01.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Lung/*physiopathology
Pulmonary Disease, Chronic Obstructive/*genetics
Smoking/*genetics
Aged ; Female ; Genetic Loci/genetics ; Genome-Wide Association Study/methods ; Genotype ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Polymorphism, Single Nucleotide/genetics ; Prospective Studies ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Respiratory Function Tests/methods ; Smokers ; White People/genetics ; alpha 1-Antitrypsin/genetics
Czasopismo naukowe
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Tytuł:
Lower serum IgA is associated with COPD exacerbation risk in SPIROMICS.
Autorzy:
Putcha N; Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Paul GG; Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Azar A; Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Wise RA; Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
O'Neal WK; University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America.
Dransfield MT; University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
Woodruff PG; University of San Francisco School of Medicine, San Francisco, California, United States of America.
Curtis JL; University of Michigan Medical School, Ann Arbor, Michigan, United States of America.; VA Ann Arbor Healthcare System, Ann Arbor, Michigan, United States of America.
Comellas AP; University of Iowa College of Medicine, Iowa City, Iowa, United States of America.
Drummond MB; University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America.
Lambert AA; Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.; University of Washington School of Medicine, Seattle, Washington, United States of America.
Paulin LM; Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Fawzy A; Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Kanner RE; University of Utah Health Sciences Center, Salt Lake City, Utah, United States of America.
Paine R 3rd; Department of Veterans Affairs Medical Center, Salt Lake City, Utah, United States of America.; University of Utah School of Medicine, Salt Lake City, Utah, United States of America.
Han MK; University of Michigan Medical School, Ann Arbor, Michigan, United States of America.
Martinez FJ; Weill Cornell Medical College. New York City, New York, United States of America.
Bowler RP; National Jewish Health, Denver, Colorado, United States of America.
Barr RG; Columbia University School of Medicine, New York, New York, United States of America.
Hansel NN; Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
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Corporate Authors:
SPIROMICS investigators
Źródło:
PloS one [PLoS One] 2018 Apr 12; Vol. 13 (4), pp. e0194924. Date of Electronic Publication: 2018 Apr 12 (Print Publication: 2018).
Typ publikacji:
Journal Article; Observational Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Immunoglobulin A/*blood
Pulmonary Disease, Chronic Obstructive/*blood
Pulmonary Disease, Chronic Obstructive/*physiopathology
Adult ; Aged ; Aged, 80 and over ; Biomarkers/blood ; Cohort Studies ; Disease Progression ; Female ; Humans ; Immunoglobulin A/immunology ; Incidence ; Male ; Middle Aged ; Regression Analysis ; Risk ; Treatment Outcome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Variability in objective and subjective measures affects baseline values in studies of patients with COPD.
Autorzy:
Anderson WH; Pulmonary and Critical Care Medicine, Department of Medicine, Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina United States of America.
Ha JW; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Couper DJ; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
O'Neal WK; Marsico Lung Institute/Cystic Fibrosis Research Center, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina United States of America.
Barr RG; Department of Medicine, Columbia University Medical Center, New York, New York, United States of America.
Bleecker ER; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
Carretta EE; Collaborative Studies Coordinating Center, Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Cooper CB; David Geffen School of Medicine, University of California, Los Angeles, California, United States of America.
Doerschuk CM; Pulmonary and Critical Care Medicine, Department of Medicine, Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina United States of America.; Marsico Lung Institute/Cystic Fibrosis Research Center, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina United States of America.
Drummond MB; Pulmonary and Critical Care Medicine, Department of Medicine, Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina United States of America.
Han MK; Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, Michigan, United States of America.
Hansel NN; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Kim V; Department of Thoracic Medicine and Surgery, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America.
Kleerup EC; Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America.
Martinez FJ; Department of Medicine, Weill Cornell Medical College, New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, New York, United States of America.
Rennard SI; Division of Pulmonary and Critical Care Medicine, University of Nebraska, Omaha, Nebraska, United States of America.
Tashkin D; Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America.
Woodruff PG; Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine and Cardiovascular Research Institute, University of California San Francisco, School of Medicine, San Francisco, California, United States of America.
Paine R 3rd; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine and Department of Veterans Affairs Medical Center, University of Utah, Salt Lake City, Utah, United States of America.
Curtis JL; Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, Michigan; VA Ann Arbor Healthcare System, Ann Arbor, Michigan, United States of America.
Kanner RE; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine and Department of Veterans Affairs Medical Center, University of Utah, Salt Lake City, Utah, United States of America.
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Corporate Authors:
SPIROMICS Research Group
Źródło:
PloS one [PLoS One] 2017 Sep 21; Vol. 12 (9), pp. e0184606. Date of Electronic Publication: 2017 Sep 21 (Print Publication: 2017).
Typ publikacji:
Journal Article; Multicenter Study
MeSH Terms:
Pulmonary Disease, Chronic Obstructive/*diagnosis
Adult ; Aged ; Aged, 80 and over ; Blood Cell Count ; Exercise Test ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Reproducibility of Results ; Smoking ; Spirometry ; Surveys and Questionnaires ; Time Factors ; Tomography, X-Ray Computed
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Polymorphisms in key pulmonary inflammatory pathways and the development of acute respiratory distress syndrome.
Autorzy:
Brown SM; 1Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Grissom CK
Rondina MT
Hoidal JR
Scholand MB
Wolff RK
Morris AH
Paine R 3rd
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Corporate Authors:
NIH/NHLBI ARDS Network
Źródło:
Experimental lung research [Exp Lung Res] 2015 Apr; Vol. 41 (3), pp. 155-62. Date of Electronic Publication: 2014 Dec 16.
Typ publikacji:
Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Genetic Predisposition to Disease/*genetics
Pneumonia/*genetics
Polymorphism, Single Nucleotide/*genetics
Receptor for Advanced Glycation End Products/*genetics
Respiratory Distress Syndrome/*genetics
Signal Transduction/*genetics
Female ; Humans ; Male ; Risk ; Risk Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Contrasting effects of hyperoxia on GM-CSF gene transcription in alveolar epithelial cells and T cells.
Autorzy:
Sturrock A; Department of Veterans, Affairs Medical Center, Salt Lake City, Utah, USA Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Baker JA; Department of Veterans, Affairs Medical Center, Salt Lake City, Utah, USA Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Mir-Kasimov M; Department of Veterans, Affairs Medical Center, Salt Lake City, Utah, USA Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Paine R 3rd; Department of Veterans, Affairs Medical Center, Salt Lake City, Utah, USA Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA robert.paine@hsc.utah.edu.
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Źródło:
Physiological reports [Physiol Rep] 2015 Mar; Vol. 3 (3).
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Design of a multi-center immunophenotyping analysis of peripheral blood, sputum and bronchoalveolar lavage fluid in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS).
Autorzy:
Freeman CM; Research Service, VA Ann Arbor Healthcare System, Ann Arbor, MI, 48105, USA. .; Pulmonary & Critical Care Medicine Division, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI, 48109, USA. .
Crudgington S; Pulmonary & Critical Care Medicine Division, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI, 48109, USA. .
Stolberg VR; Research Service, VA Ann Arbor Healthcare System, Ann Arbor, MI, 48105, USA. .
Brown JP; Pulmonary & Critical Care Medicine Division, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI, 48109, USA. .
Sonstein J; Pulmonary & Critical Care Medicine Division, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI, 48109, USA. .
Alexis NE; Center for Environmental Medicine, Asthma, and Lung Biology, Chapel Hill, NC, 27599, USA. Neil_.
Doerschuk CM; Center for Airways Disease, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. .
Basta PV; Marsico Lung Institute/University of North Carolina Cystic Fibrosis Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. .
Carretta EE; Marsico Lung Institute/University of North Carolina Cystic Fibrosis Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. .
Couper DJ; Marsico Lung Institute/University of North Carolina Cystic Fibrosis Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. david_.
Hastie AT; Center for Genomics and Personalized Medicine, Wake Forest University, Winston-Salem, NC, 27157, USA. .
Kaner RJ; Division of Pulmonary and Critical Care Medicine, Departments of Medicine and Genetic Medicine, Weill Cornell Medical College, New York, NY, 10021, USA. .
O'Neal WK; Marsico Lung Institute/University of North Carolina Cystic Fibrosis Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. .
Paine R 3rd; Division of Pulmonary, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, 84112, USA. robert.paine@hsc.utah.edu.
Rennard SI; Pulmonary, Critical Care, Sleep and Allergy Division, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 68198, USA. .
Shimbo D; Department of Medicine, Columbia University Medical Center, New York, NY, 10032, USA. .
Woodruff PG; Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of California at San Francisco, San Francisco, CA, 94143, USA. .
Zeidler M; Division of Pulmonary, Critical Care, and Sleep Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, 90095, USA. .
Curtis JL; Pulmonary & Critical Care Medicine Section, Medicine Service, VA Ann Arbor Healthcare System, Ann Arbor, MI, 48105, USA. .; Pulmonary & Critical Care Medicine Division, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI, 48109, USA. .; Pulmonary and Critical Care Medicine Section (506/111G), Department of Veterans Affairs Healthsystem, 2215 Fuller Road, Ann Arbor, MI, 48105-2303, USA. .
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Źródło:
Journal of translational medicine [J Transl Med] 2015 Jan 27; Vol. 13, pp. 19. Date of Electronic Publication: 2015 Jan 27.
Typ publikacji:
Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Bronchoalveolar Lavage Fluid*
Immunophenotyping/*methods
Pulmonary Disease, Chronic Obstructive/*blood
Pulmonary Disease, Chronic Obstructive/*metabolism
Sputum/*metabolism
Biomarkers ; CD4-Positive T-Lymphocytes/cytology ; CD8-Positive T-Lymphocytes/cytology ; Cell Separation ; Dendritic Cells/cytology ; Flow Cytometry ; Humans ; Leukocytes/cytology ; Longitudinal Studies ; Macrophages/cytology ; Phenotype ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Research Design ; Sample Size ; Smoking ; Spirometry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Sputum biomarkers and the prediction of clinical outcomes in patients with cystic fibrosis.
Autorzy:
Liou TG; Department of Medicine, School of Medicine, University of Utah, Salt Lake City, Utah, USA. />Adler FR
Keogh RH
Li Y
Jensen JL
Walsh W
Packer K
Clark T
Carveth H
Chen J
Rogers SL
Lane C
Moore J
Sturrock A
Paine R 3rd
Cox DR
Hoidal JR
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Źródło:
PloS one [PLoS One] 2012; Vol. 7 (8), pp. e42748. Date of Electronic Publication: 2012 Aug 10.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Validation Study
MeSH Terms:
Biomarkers/*metabolism
Cystic Fibrosis/*physiopathology
Sputum/*metabolism
Adult ; Cohort Studies ; Cystic Fibrosis/metabolism ; Cystic Fibrosis/surgery ; Granulocyte-Macrophage Colony-Stimulating Factor/metabolism ; HMGB1 Protein/metabolism ; Humans ; Lung Transplantation ; Prognosis ; Treatment Outcome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Impaired transcriptional activity of Nrf2 in age-related myocardial oxidative stress is reversible by moderate exercise training.
Autorzy:
Gounder SS; Divisions of Cardiology and Pulmonary, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA.
Kannan S
Devadoss D
Miller CJ
Whitehead KJ
Odelberg SJ
Firpo MA
Paine R 3rd
Hoidal JR
Abel ED
Rajasekaran NS
Pokaż więcej
Źródło:
PloS one [PLoS One] 2012; Vol. 7 (9), pp. e45697. Date of Electronic Publication: 2012 Sep 24.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Oxidative Stress*
Physical Conditioning, Animal*
Transcription, Genetic*
Myocardium/*metabolism
NF-E2-Related Factor 2/*metabolism
Animals ; Blotting, Western ; Electron Spin Resonance Spectroscopy ; Fluorescent Dyes ; Glutathione/metabolism ; Homeostasis ; Male ; Mice ; Mice, Inbred C57BL ; Oxidation-Reduction ; Reactive Oxygen Species/metabolism ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 22

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