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Tytuł:
Anti-malarial activity of the root extract of Euphorbia abyssinica (Euphorbiaceae) against Plasmodium berghei infection in mice.
Autorzy:
Muluye AB; Department of Pharmacy, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia. .
Desta AG; Department of Pharmacy, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.
Abate SK; Department of Pharmacy, College of Health Sciences, Wachamo University, Hosanna, Ethiopia.
Dano GT; Department of Medical Laboratory Sciences, College of Health Sciences, Wollega University, Nekemte, Ethiopia.
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Źródło:
Malaria journal [Malar J] 2019 Jul 30; Vol. 18 (1), pp. 261. Date of Electronic Publication: 2019 Jul 30.
Typ publikacji:
Journal Article
MeSH Terms:
Antimalarials/*pharmacology
Euphorbia/*chemistry
Malaria/*prevention & control
Plant Extracts/*pharmacology
Plasmodium berghei/*drug effects
Animals ; Antimalarials/chemistry ; Antimalarials/toxicity ; Body Weight/drug effects ; Dose-Response Relationship, Drug ; Female ; Longevity/drug effects ; Malaria/parasitology ; Male ; Mice ; Parasitemia/parasitology ; Parasitemia/prevention & control ; Plant Extracts/chemistry ; Plant Extracts/toxicity ; Plant Roots/chemistry ; Random Allocation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Effects of Azadirachta indica seed kernel extracts on early erythrocytic schizogony of Plasmodium berghei and pro-inflammatory response in inbred mice.
Autorzy:
Habluetzel A; School of Pharmacy, University of Camerino, Camerino, Italy.
Pinto B; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Tapanelli S; School of Pharmacy, University of Camerino, Camerino, Italy.; Department of Life Sciences, Imperial College London, London, UK.
Nkouangang J; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Saviozzi M; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Chianese G; Department of Pharmacy, University of Naples, Federico II, Naples, Italy.
Lopatriello A; Department of Pharmacy, University of Naples, Federico II, Naples, Italy.
Tenoh AR; School of Pharmacy, University of Camerino, Camerino, Italy.
Yerbanga RS; Institut de Recherche en Sciences de la Santé, 01BP545, Bobo Dioulasso, Burkina Faso.
Taglialatela-Scafati O; Department of Pharmacy, University of Naples, Federico II, Naples, Italy.
Esposito F; School of Pharmacy, University of Camerino, Camerino, Italy.
Bruschi F; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy. .
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Źródło:
Malaria journal [Malar J] 2019 Feb 08; Vol. 18 (1), pp. 35. Date of Electronic Publication: 2019 Feb 08.
Typ publikacji:
Journal Article
MeSH Terms:
Antimalarials/*pharmacology
Azadirachta/*chemistry
Malaria/*drug therapy
Parasitemia/*drug therapy
Plant Extracts/*pharmacology
Plasmodium berghei/*drug effects
Animals ; Drug Delivery Systems ; Erythrocytes/parasitology ; Female ; Inflammation/drug therapy ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Plants, Medicinal/chemistry ; Seeds/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Landolphia owariensis leaf extracts reduce parasitemia in Plasmodium berghei-infected mice.
Autorzy:
Ezike AC; a Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences , University of Nigeria , Nsukka , Enugu State , Nigeria.
Okonkwo CH; a Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences , University of Nigeria , Nsukka , Enugu State , Nigeria.
Akah PA; a Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences , University of Nigeria , Nsukka , Enugu State , Nigeria.
Okoye TC; a Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences , University of Nigeria , Nsukka , Enugu State , Nigeria.
Nworu CS; a Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences , University of Nigeria , Nsukka , Enugu State , Nigeria.
Mbaoji FN; a Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences , University of Nigeria , Nsukka , Enugu State , Nigeria.
Nwabunike IA; a Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences , University of Nigeria , Nsukka , Enugu State , Nigeria.
Onyeto CA; a Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences , University of Nigeria , Nsukka , Enugu State , Nigeria.
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Źródło:
Pharmaceutical biology [Pharm Biol] 2016 Oct; Vol. 54 (10), pp. 2017-25. Date of Electronic Publication: 2016 Feb 25.
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
Apocynaceae*/chemistry
Antimalarials/*pharmacology
Malaria/*drug therapy
Parasitemia/*drug therapy
Plant Extracts/*pharmacology
Plasmodium berghei/*drug effects
Administration, Oral ; Animals ; Antimalarials/administration & dosage ; Antimalarials/isolation & purification ; Antimalarials/toxicity ; Chromatography, High Pressure Liquid ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Lethal Dose 50 ; Malaria/parasitology ; Parasitemia/parasitology ; Phytotherapy ; Plant Extracts/administration & dosage ; Plant Extracts/isolation & purification ; Plant Extracts/toxicity ; Plant Leaves ; Plants, Medicinal ; Plasmodium berghei/growth & development ; Solvents/chemistry ; Time Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Pre-infection administration of asiatic acid retards parasitaemia induction in Plasmodium berghei murine malaria infected Sprague-Dawley rats.
Autorzy:
Mavondo GA; Discipline of Human Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu Natal, Westville Campus, Durban, 4000, South Africa. .
Mkhwananzi BN; Discipline of Human Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu Natal, Westville Campus, Durban, 4000, South Africa.
Mabandla MV; Discipline of Human Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu Natal, Westville Campus, Durban, 4000, South Africa.
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Źródło:
Malaria journal [Malar J] 2016 Apr 21; Vol. 15, pp. 226. Date of Electronic Publication: 2016 Apr 21.
Typ publikacji:
Controlled Clinical Trial; Journal Article
MeSH Terms:
Pre-Exposure Prophylaxis*
Antimalarials/*pharmacology
Malaria/*prevention & control
Parasitemia/*prevention & control
Pentacyclic Triterpenes/*pharmacology
Plasmodium berghei/*drug effects
Animals ; Antimalarials/administration & dosage ; Chloroquine/administration & dosage ; Disease Models, Animal ; Malaria/parasitology ; Male ; Mice ; Parasitemia/parasitology ; Pentacyclic Triterpenes/administration & dosage ; Plasmodium berghei/physiology ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Efficacy and safety evaluation of a novel trioxaquine in the management of cerebral malaria in a mouse model.
Autorzy:
Odhiambo OC; Department of Biochemistry, Jomo Kenyatta University of Agriculture and Technology, P.O. Box 62000, Nairobi, Kenya.
Wamakima HN; Department of Pharmaceutical Sciences, Mount Kenya University, P.O. Box 342-01000, Thika, Kenya.
Magoma GN; Department of Biochemistry, Jomo Kenyatta University of Agriculture and Technology, P.O. Box 62000, Nairobi, Kenya.
Kirira PG; Department of Physical Sciences, Mount Kenya University, P.O. Box 342-01000, Thika, Kenya.
Malala BJ; Department of Biological Sciences, Mount Kenya University, P.O. Box 342-01000, Thika, Kenya.
Kimani FT; Centre for Biotechnology Research and Development, Kenya Medical Research Institute (KEMRI), P.O. Box 54840, Nairobi, Kenya.
Muregi FW; Department of Biological Sciences, Mount Kenya University, P.O. Box 342-01000, Thika, Kenya. .
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Źródło:
Malaria journal [Malar J] 2017 Jul 03; Vol. 16 (1), pp. 268. Date of Electronic Publication: 2017 Jul 03.
Typ publikacji:
Journal Article
MeSH Terms:
Antimalarials/*therapeutic use
Heterocyclic Compounds/*therapeutic use
Malaria, Cerebral/*drug therapy
Plasmodium berghei/*drug effects
Animals ; Antimalarials/pharmacology ; Artemisinins/pharmacology ; Artemisinins/therapeutic use ; Artesunate ; Blood-Brain Barrier/metabolism ; Disease Models, Animal ; Drug Evaluation ; Heterocyclic Compounds/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Parasitemia/drug therapy ; Quinine/pharmacology ; Quinine/therapeutic use ; Quinolines/pharmacology ; Quinolines/therapeutic use ; Random Allocation ; Safety
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
In vivo antiplasmodial and toxicological effect of crude ethanol extract of Echinops kebericho traditionally used in treatment of malaria in Ethiopia.
Autorzy:
Toma A; Pharmacology Unit, School of Medicine, Hawassa University, PO Box 1560, Hawassa, Ethiopia. .
Deyno S; Pharmacology Unit, School of Medicine, Hawassa University, PO Box 1560, Hawassa, Ethiopia. .
Fikru A; Biomedical team, School of Veterinary Medicine, Hawassa University, Hawassa, Ethiopia. .
Eyado A; Department of Biology, College of Natural and Computational Sciences, Addis Ababa University, Addis Ababa, Ethiopia. .
Beale A; Independent scholar, AuthorAID Mentor, Milange, Mozambique. .
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Źródło:
Malaria journal [Malar J] 2015 May 10; Vol. 14, pp. 196. Date of Electronic Publication: 2015 May 10.
Typ publikacji:
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Antimalarials/*pharmacology
Antimalarials/*therapeutic use
Asteraceae/*chemistry
Malaria/*drug therapy
Phytotherapy/*adverse effects
Plasmodium berghei/*drug effects
Administration, Oral ; Animals ; Antimalarials/administration & dosage ; Body Weight/drug effects ; Ethiopia ; Hematocrit/adverse effects ; Longevity/drug effects ; Male ; Mice ; Parasitemia/drug therapy ; Parasitemia/parasitology ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Plant Roots/chemistry ; Plants, Medicinal/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
High Dietary Folate in Mice Alters Immune Response and Reduces Survival after Malarial Infection.
Autorzy:
Meadows DN; Department of Human Genetics, McGill University, McGill University Health Center, Montreal, Quebec, Canada.
Bahous RH; Department of Human Genetics, McGill University, McGill University Health Center, Montreal, Quebec, Canada.
Best AF; Department of Mathematics and Statistics, McGill University, Montreal, Quebec, Canada.
Rozen R; Department of Human Genetics, McGill University, McGill University Health Center, Montreal, Quebec, Canada.; Department of Pediatrics, McGill University, McGill University Health Center, Montreal, Quebec, Canada.
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Źródło:
PloS one [PLoS One] 2015 Nov 24; Vol. 10 (11), pp. e0143738. Date of Electronic Publication: 2015 Nov 24 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antimalarials/*therapeutic use
Folic Acid/*adverse effects
Malaria/*drug therapy
Plasmodium berghei/*pathogenicity
Animals ; Malaria, Cerebral/drug therapy ; Mice ; Parasitemia/drug therapy ; Plasmodium berghei/drug effects ; Proportional Hazards Models ; T-Lymphocytes/metabolism ; bcl-2 Homologous Antagonist-Killer Protein/genetics ; bcl-2 Homologous Antagonist-Killer Protein/metabolism ; bcl-X Protein/genetics ; bcl-X Protein/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
From METS to malaria: RRx-001, a multi-faceted anticancer agent with activity in cerebral malaria.
Autorzy:
Yalcin O; Department of Bioengineering, University of California, 9500 Gilman Dr., La Jolla, San Diego, CA, 92093-0412, USA. .; School of Medicine, Koç University, Sariyer, Istanbul, Turkey. .
Oronsky B; EpicentRx Inc, Mountain View, CA, USA. .
Carvalho LJ; Center for Malaria Research, La Jolla Bioengineering Institute, San Diego, CA, USA. .; Laboratory of Malaria Research, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil. .
Kuypers FA; Children's Hospital Oakland Research Institute, Oakland, CA, USA. .
Scicinski J; EpicentRx Inc, Mountain View, CA, USA. .
Cabrales P; Department of Bioengineering, University of California, 9500 Gilman Dr., La Jolla, San Diego, CA, 92093-0412, USA. .
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Źródło:
Malaria journal [Malar J] 2015 May 28; Vol. 14, pp. 218. Date of Electronic Publication: 2015 May 28.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Antimalarials/*therapeutic use
Artemisinins/*therapeutic use
Azetidines/*therapeutic use
Malaria, Cerebral/*drug therapy
Nitro Compounds/*therapeutic use
Plasmodium berghei/*drug effects
Animals ; Artemether ; Carboxylic Ester Hydrolases/metabolism ; Disease Models, Animal ; Drug Combinations ; Glucosephosphate Dehydrogenase/metabolism ; Humans ; Mice ; Mice, Inbred C57BL ; Motor Activity ; Parasitemia/drug therapy
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
In vivo antiplasmodial and toxicological effect of Maytenus senegalensis traditionally used in the treatment of malaria in Tanzania.
Autorzy:
Malebo HM; Department of Traditional Medicine Research, National Institute for Medical Research, 3 Barack Obama Drive, P.O. Box 9653, 11101, Dar es Salaam, Tanzania. .
Wiketye V; Ngongongare Medical Research Centre, P.O Box 514, Usa River, Arusha, Tanzania. .
Katani SJ; Department of Traditional Medicine Research, National Institute for Medical Research, 3 Barack Obama Drive, P.O. Box 9653, 11101, Dar es Salaam, Tanzania. .
Kitufe NA; Department of Traditional Medicine Research, National Institute for Medical Research, 3 Barack Obama Drive, P.O. Box 9653, 11101, Dar es Salaam, Tanzania. .
Nyigo VA; Department of Traditional Medicine Research, National Institute for Medical Research, 3 Barack Obama Drive, P.O. Box 9653, 11101, Dar es Salaam, Tanzania. .
Imeda CP; Department of Traditional Medicine Research, National Institute for Medical Research, 3 Barack Obama Drive, P.O. Box 9653, 11101, Dar es Salaam, Tanzania. .
Ogondiek JW; Ngongongare Medical Research Centre, P.O Box 514, Usa River, Arusha, Tanzania. .
Sunguruma R; Department of Traditional Medicine Research, National Institute for Medical Research, 3 Barack Obama Drive, P.O. Box 9653, 11101, Dar es Salaam, Tanzania. .
Mhame PP; Traditional Medicine Unit, Ministry of Health and Social Welfare, P.O. Box 9083, Dar es Salaam, Tanzania. .
Massaga JJ; Headquarters, National Institute for Medical Research, 3 Barack Obama Drive, P.O. Box 9653, 11101, Dar es Salaam, Tanzania. .
Mammuya B; Government Chemist Laboratory Agency, P. O. Box 164, Dar es Salaam, Tanzania. .
Senkoro KP; Headquarters, National Institute for Medical Research, 3 Barack Obama Drive, P.O. Box 9653, 11101, Dar es Salaam, Tanzania. .
Rumisha SF; Headquarters, National Institute for Medical Research, 3 Barack Obama Drive, P.O. Box 9653, 11101, Dar es Salaam, Tanzania. .
Malecela MN; Headquarters, National Institute for Medical Research, 3 Barack Obama Drive, P.O. Box 9653, 11101, Dar es Salaam, Tanzania. .
Kitua AY; Headquarters, National Institute for Medical Research, 3 Barack Obama Drive, P.O. Box 9653, 11101, Dar es Salaam, Tanzania. .
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Źródło:
Malaria journal [Malar J] 2015 Feb 14; Vol. 14, pp. 79. Date of Electronic Publication: 2015 Feb 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antimalarials/*pharmacology
Malaria/*drug therapy
Maytenus/*chemistry
Plant Extracts/*pharmacology
Plasmodium berghei/*drug effects
Administration, Oral ; Animals ; Female ; Lethal Dose 50 ; Malaria/parasitology ; Male ; Mice ; Parasitemia/drug therapy ; Parasitemia/parasitology ; Plant Bark/chemistry ; Plant Roots/chemistry ; Plants, Medicinal/chemistry ; Tanzania
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Azadirachta indica extract-artesunic acid combination produces an increased cure rate of Plasmodium berghei-infected mice.
Autorzy:
Anagu OL; Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University , Awka , Nigeria .
Attama AA
Okore VC
Gugu HT
Ngene AA
Esimone CO
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Źródło:
Pharmaceutical biology [Pharm Biol] 2014 Jul; Vol. 52 (7), pp. 883-9. Date of Electronic Publication: 2014 Feb 07.
Typ publikacji:
Journal Article
MeSH Terms:
Phytotherapy*
Antimalarials/*therapeutic use
Artemisinins/*therapeutic use
Azadirachta/*chemistry
Malaria/*drug therapy
Plant Extracts/*therapeutic use
Plasmodium berghei/*drug effects
Succinates/*therapeutic use
Animals ; Antimalarials/pharmacology ; Artemisinins/administration & dosage ; Artemisinins/pharmacology ; Dose-Response Relationship, Drug ; Drug Therapy, Combination ; Female ; Malaria/parasitology ; Mice ; Parasitemia/drug therapy ; Parasitemia/parasitology ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Plant Leaves/chemistry ; Schizonts/drug effects ; Succinates/administration & dosage ; Succinates/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Anti-malarial activity and toxicity assessment of Himatanthus articulatus, a plant used to treat malaria in the Brazilian Amazon.
Autorzy:
Vale VV; Programa de Pós-graduação em Ciências Farmacêuticas, Instituto de Ciências da Saúde (ICS), Universidade Federal do Pará (UFPA), Rua Augusto Corrêa 1, 68075-110, Belém, PA, Brazil. .
Vilhena TC; Programa de Pós-graduação em Ciências Farmacêuticas, Instituto de Ciências da Saúde (ICS), Universidade Federal do Pará (UFPA), Rua Augusto Corrêa 1, 68075-110, Belém, PA, Brazil. .
Trindade RC; Departamento de Botânica, Museu Paraense Emilio Goeldi, Belém, PA, Brazil. .
Ferreira MR; Departamento de Botânica, Museu Paraense Emilio Goeldi, Belém, PA, Brazil. .
Percário S; Laboratório de Pesquisa em Estresse Oxidativo, Instituto de Ciências Biológicas (ICB), Universidade Federal do Pará (UFPA), Belém, PA, Brazil. .; US Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA. .
Soares LF; Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. .
Pereira WL; Departamento de Patologia Veterinária e Medicina Preventiva, Instituto de Saúde e Produção Animal (ISPA), Universidade Federal Rural da Amazônia, Belém, PA, Brazil. .
Brandão GC; Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil. .
Oliveira AB; Programa de Pós-graduação em Ciências Farmacêuticas, Instituto de Ciências da Saúde (ICS), Universidade Federal do Pará (UFPA), Rua Augusto Corrêa 1, 68075-110, Belém, PA, Brazil. .; Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. .
Dolabela MF; Programa de Pós-graduação em Ciências Farmacêuticas, Instituto de Ciências da Saúde (ICS), Universidade Federal do Pará (UFPA), Rua Augusto Corrêa 1, 68075-110, Belém, PA, Brazil. .; Programa de Pós-graduação em Inovação Farmacêutica, Instituto de Ciências da Saúde (ICS), Universidade Federal do Pará (UFPA), Belém, PA, Brazil. .
De Vasconcelos F; Programa de Pós-graduação em Ciências Farmacêuticas, Instituto de Ciências da Saúde (ICS), Universidade Federal do Pará (UFPA), Rua Augusto Corrêa 1, 68075-110, Belém, PA, Brazil. .
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Źródło:
Malaria journal [Malar J] 2015 Mar 27; Vol. 14, pp. 132. Date of Electronic Publication: 2015 Mar 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antimalarials/*pharmacology
Antimalarials/*toxicity
Apocynaceae/*chemistry
Plant Extracts/*pharmacology
Plant Extracts/*toxicity
Plasmodium berghei/*drug effects
Plasmodium falciparum/*drug effects
Animals ; Antimalarials/adverse effects ; Antimalarials/isolation & purification ; Brazil ; Cell Line ; Cell Survival/drug effects ; Female ; Humans ; Malaria/drug therapy ; Male ; Mice ; Parasitemia/drug therapy ; Plant Bark/chemistry ; Plant Extracts/adverse effects ; Plant Extracts/isolation & purification ; Plant Stems/chemistry ; Treatment Outcome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Lambda-carrageenan treatment exacerbates the severity of cerebral malaria caused by Plasmodium berghei ANKA in BALB/c mice.
Autorzy:
Recuenco FC
Takano R
Chiba S
Sugi T
Takemae H
Murakoshi F
Ishiwa A
Inomata A
Horimoto T
Kobayashi Y
Horiuchi N
Kato K; Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan. .
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Źródło:
Malaria journal [Malar J] 2014 Dec 11; Vol. 13, pp. 487. Date of Electronic Publication: 2014 Dec 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antimalarials/*adverse effects
Carrageenan/*adverse effects
Immunologic Factors/*adverse effects
Malaria, Cerebral/*drug therapy
Malaria, Cerebral/*pathology
Plasmodium berghei/*drug effects
Animals ; Antimalarials/administration & dosage ; Carrageenan/administration & dosage ; Disease Models, Animal ; Female ; Immunologic Factors/administration & dosage ; Malaria, Cerebral/parasitology ; Mice, Inbred BALB C ; Parasitemia/diagnosis ; Survival Analysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
In vitro and in vivo anti-malarial activity of tigecycline, a glycylcycline antibiotic, in combination with chloroquine.
Autorzy:
Sahu R
Walker LA
Tekwani BL; National Center for Natural Product Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA. .
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Źródło:
Malaria journal [Malar J] 2014 Oct 21; Vol. 13, pp. 414. Date of Electronic Publication: 2014 Oct 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Antimalarials/*pharmacology
Chloroquine/*pharmacology
Malaria/*drug therapy
Minocycline/*analogs & derivatives
Plasmodium berghei/*drug effects
Plasmodium falciparum/*drug effects
Animals ; Antimalarials/therapeutic use ; Chloroquine/therapeutic use ; Disease Models, Animal ; Malaria/mortality ; Malaria/parasitology ; Male ; Mice ; Minocycline/pharmacology ; Minocycline/therapeutic use ; Parasitemia ; Parasitic Sensitivity Tests ; Tigecycline
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Anti-malarial property of steroidal alkaloid conessine isolated from the bark of Holarrhena antidysenterica.
Autorzy:
Dua VK; Field Unit, Sector-3, Health Centre, BHEL, National Institute of Malaria Research, Hardwar 249403, India. />Verma G
Singh B
Rajan A
Bagai U
Agarwal DD
Gupta NC
Kumar S
Rastogi A
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Źródło:
Malaria journal [Malar J] 2013 Jun 10; Vol. 12, pp. 194. Date of Electronic Publication: 2013 Jun 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alkaloids/*pharmacology
Antimalarials/*pharmacology
Holarrhena/*chemistry
Plant Extracts/*pharmacology
Plasmodium berghei/*drug effects
Alkaloids/therapeutic use ; Alkaloids/toxicity ; Animals ; Antimalarials/isolation & purification ; Antimalarials/therapeutic use ; Antimalarials/toxicity ; Cell Survival/drug effects ; Disease Models, Animal ; Female ; Inhibitory Concentration 50 ; Malaria/drug therapy ; Malaria/parasitology ; Malaria/pathology ; Male ; Mice ; Mice, Inbred BALB C ; Myoblasts/drug effects ; Myoblasts/physiology ; Parasite Load ; Parasitemia/drug therapy ; Parasitemia/parasitology ; Parasitemia/pathology ; Plant Extracts/isolation & purification ; Plant Extracts/therapeutic use ; Plant Extracts/toxicity ; Rats ; Treatment Outcome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A new in vivo screening paradigm to accelerate antimalarial drug discovery.
Autorzy:
Jiménez-Díaz MB; Tres Cantos Medicines Development Campus, GlaxoSmithKline, Tres Cantos, Spain.
Viera S
Ibáñez J
Mulet T
Magán-Marchal N
Garuti H
Gómez V
Cortés-Gil L
Martínez A
Ferrer S
Fraile MT
Calderón F
Fernández E
Shultz LD
Leroy D
Wilson DM
García-Bustos JF
Gamo FJ
Angulo-Barturen I
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Źródło:
PloS one [PLoS One] 2013 Jun 25; Vol. 8 (6), pp. e66967. Date of Electronic Publication: 2013 Jun 25 (Print Publication: 2013).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antimalarials/*pharmacology
Drug Evaluation, Preclinical/*methods
Plasmodium berghei/*drug effects
Animals ; Antimalarials/therapeutic use ; Feasibility Studies ; Female ; Humans ; Malaria/complications ; Malaria/drug therapy ; Mice ; Parasitemia/complications ; Plasmodium berghei/physiology ; Time Factors
Czasopismo naukowe
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Tytuł:
A lactate dehydrogenase ELISA-based assay for the in vitro determination of Plasmodium berghei sensitivity to anti-malarial drugs.
Autorzy:
Orjuela-Sánchez P; La Jolla Bioengineering Institute, 3535 General Atomics Court, Suite 210, San Diego, California 92121, USA. />Duggan E
Nolan J
Frangos JA
Carvalho LJ
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Źródło:
Malaria journal [Malar J] 2012 Nov 05; Vol. 11, pp. 366. Date of Electronic Publication: 2012 Nov 05.
Typ publikacji:
Evaluation Study; Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Antimalarials/*pharmacology
Enzyme-Linked Immunosorbent Assay/*methods
L-Lactate Dehydrogenase/*analysis
Plasmodium berghei/*drug effects
Plasmodium berghei/*enzymology
Animals ; Antibodies, Monoclonal ; Antibodies, Protozoan ; Drug Evaluation, Preclinical ; Drug Resistance ; Green Fluorescent Proteins/genetics ; L-Lactate Dehydrogenase/immunology ; Malaria/drug therapy ; Malaria/parasitology ; Mice ; Mice, Inbred C57BL ; Parasitemia/drug therapy ; Parasitemia/parasitology ; Plasmodium berghei/genetics ; Recombinant Proteins/genetics
Czasopismo naukowe
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Tytuł:
Risk assessment and therapeutic indices of artesunate and artelinate in Plasmodium berghei-infected and uninfected rats.
Autorzy:
Xie LH; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20307-5100, USA.
Johnson TO
Weina PJ
Si Y
Haeberle A
Upadhyay R
Wong E
Li Q
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Źródło:
International journal of toxicology [Int J Toxicol] 2005 Jul-Aug; Vol. 24 (4), pp. 251-64.
Typ publikacji:
Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Plasmodium berghei*
Antimalarials/*toxicity
Artemisinins/*toxicity
Malaria/*drug therapy
Sesquiterpenes/*toxicity
Anemia/chemically induced ; Animals ; Antimalarials/administration & dosage ; Artemisinins/administration & dosage ; Artemisinins/pharmacokinetics ; Artesunate ; Body Weight/drug effects ; Dose-Response Relationship, Drug ; Erythrocyte Count ; Female ; Hematocrit ; Malaria/blood ; Malaria/parasitology ; Male ; Maximum Tolerated Dose ; Parasitemia/drug therapy ; Rats ; Rats, Sprague-Dawley ; Reticulocyte Count ; Risk Assessment ; Sesquiterpenes/administration & dosage ; Sesquiterpenes/pharmacokinetics ; Sex Factors ; Therapeutic Equivalency ; Time Factors
Czasopismo naukowe
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Tytuł:
The chemotherapy of rodent malaria. LX. The importance of formulation in evaluating the blood schizontocidal activity of some endoperoxide antimalarials.
Autorzy:
Peters W; Centre for Tropical Antiprotozoal Chemotherapy, Y Block, Northwick Park Institute for Medical Research, Harrow HA1 3UJ, UK. />Fleck SL
Robinson BL
Stewart LB
Jefford CW
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Źródło:
Annals of tropical medicine and parasitology [Ann Trop Med Parasitol] 2002 Sep; Vol. 96 (6), pp. 559-73.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Peroxides*
Plasmodium berghei*
Plasmodium yoelii*
Antimalarials/*administration & dosage
Malaria/*drug therapy
Parasitemia/*drug therapy
Administration, Oral ; Animals ; Antimalarials/therapeutic use ; Artemisinins/administration & dosage ; Artemisinins/therapeutic use ; Bridged Bicyclo Compounds, Heterocyclic/administration & dosage ; Bridged Bicyclo Compounds, Heterocyclic/therapeutic use ; Chemistry, Pharmaceutical ; Corn Oil ; Drug Carriers ; Drug Evaluation, Preclinical ; Injections, Subcutaneous ; Lipids ; Mice ; Sesquiterpenes/administration & dosage ; Sesquiterpenes/therapeutic use ; Spiro Compounds/administration & dosage ; Spiro Compounds/therapeutic use ; Styrenes/administration & dosage ; Styrenes/therapeutic use ; Water
Czasopismo naukowe
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Tytuł:
The effect of nitric oxide on the growth of Plasmodium falciparum, P. chabaudi and P. berghei in vitro.
Autorzy:
Balmer P; Department of Vetinary Parisitology, University of Glasgow, UK.
Phillips HM
Maestre AE
McMonagle FA
Phillips RS
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Źródło:
Parasite immunology [Parasite Immunol] 2000 Feb; Vol. 22 (2), pp. 97-106.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antimalarials/*pharmacology
Nitric Oxide/*pharmacology
Plasmodium berghei/*drug effects
Plasmodium chabaudi/*drug effects
Plasmodium falciparum/*drug effects
Animals ; Dose-Response Relationship, Drug ; Erythrocytes/parasitology ; Female ; Humans ; Hypoxanthine/metabolism ; Malaria/blood ; Malaria/parasitology ; Male ; Mice ; Parasitemia ; Penicillamine/analogs & derivatives ; Penicillamine/pharmacology ; Plasmodium berghei/growth & development ; Plasmodium berghei/metabolism ; Plasmodium chabaudi/growth & development ; Plasmodium chabaudi/metabolism ; Plasmodium falciparum/growth & development ; Plasmodium falciparum/metabolism ; Tritium
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
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